Credits: King's College Hospital NHS Foundation Trust
Eight-month-old twins from Hayward Heath, West Sussex, recently met the surgeon who saved their lives even before they were born. The BBC reports how their mother, Katerina Ahouansou, at six months pregnant, during a routine scan, uncovered a serious issue with their development and blood supply.
Doctors diagnosed the twins with twin-to-twin transfusion syndrome or TTTS. It is a condition where one twin received more blood and nourishment than the other due to uneven blood vessel distribution in the placenta. In case there is no medical intervention, it could be fatal for both the twins.
This is when Ahouansou was referred to Professor Kypros Nicolaides at King’s College Hospital in London. Professor Nicolaides is a pioneer in fetal medicine and he specializes in a laser procedure that redistributes blood supply between twins in cases of TTTS.
When Ahouansou was scanned, Nicolaides observed that one of the twins were significantly smaller than the other. "There was a very high chance that if we did not intervene, both twins could die," he recalled.
The life-saving laser surgery was performed and within a week the doctors saw an improvement with the twin who was smaller in size. When the twins were born, they weighed 1.5kg and 1.7kg. To recognize the efforts by the surgeon, Ahouansou named them Kai Kypros and Asher Nicolas after Professor Kypros Nicolaides.
Ahouansou also expressed deep gratitude for the professor's expertise and called him "proof that miracles can be performed by people who are devotees to their profession."
Professor Kypros Nicolaides has been at King’s College Hospital since 1980 and is widely regarded as a leader in fetal medicine. His groundbreaking research and development of screening and surgical techniques have saved countless lives.
Through his dedication, Professor Nicolaides has given many families hope, demonstrating how medical advancements continue to improve survival rates for complex fetal conditions like TTTS.
As per the John Hopkins Medicine, TTTS is a rare pregnancy condition that affects identical twins or other multiples. It happens in pregnancies where twins share one placenta and a network of blood vessels that supply oxygen and nutrients essential for development in the womb. These pregnancies are known as monochorionic.
Sometimes, the blood vessels in the placenta are unevenly distributed, causing an imbalance in blood flow between the twins. The donor twin loses more blood than it receives, leading to malnutrition and potential organ failure. Meanwhile, the recipient twin gets an excess of blood, putting strain on the heart and increasing the risk of cardiac complications.
The donor twin loses blood volume (hypovolemia), reducing kidney function and urine production. This leads to low amniotic fluid levels (oligohydramnios) or, in severe cases, a complete absence (anhydramnios). Without proper blood circulation, the donor twin faces cardiovascular issues, increasing the risk of death.
The recipient twin experiences excess blood volume (hypervolemia), causing increased urination and excessive amniotic fluid (polyhydramnios). The overworked heart struggles to handle the surplus blood, leading to cardiovascular dysfunction, heart failure, and, in extreme cases, death.
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Model and entrepreneur Hailey Bieber recently opened up about her postpartum journey, shifting focus on one of the least-discussed aspects of women’s health: premenstrual dysphoric disorder (PMDD).
Hailey said that she experienced PMDD after the birth of her son, Jack Blues Bieber. It is a menstrual health condition that can cause intense emotional and physical symptoms.
In an interview with Women's Wear Daily, Bieber spoke about how motherhood drew her towards women's health, especially considering the challenges she faced after childbirth.
"After I had my son, I struggled with [PMDD] a bit, and there's just not a lot of conversation or research around it," she said.
Bieber, who welcomed her son with husband Justin Bieber in August 2024, had previously discussed her diagnosis during an appearance on the SHE MD podcast in March 2026. She said she was diagnosed approximately six months after giving birth.
Although she had experienced premenstrual syndrome (PMS) before pregnancy, she noticed that the emotional symptoms leading up to her period had become much more intense.
"I was like, 'This just feels way more intense than before,' like, the lead-up to getting your period," she said.
She said she experienced overwhelming emotions, adding, “Why does it feel like my whole entire life is gonna end? Like, I don't understand.”
Bieber said her symptoms gradually improved over time. She also highlighted how speaking about her experience helped her feel less isolated. "Conversation, for me personally, makes me feel less alone," she said.
Also read: 8 Signs Of 'Pregnancy' That Are Likely PMS
Premenstrual dysphoric disorder is a severe form of premenstrual syndrome (PMS) that causes intense emotional, mental and physical symptoms during the days leading up to menstruation.
Symptoms usually surface one to two weeks before a period and improve within a few days after menstruation starts.
Unlike premenstrual syndrome, PMDD can significantly interfere with a person's ability to work, relationships, social life and other daily activities. According to the UK's National Health Service (NHS), common symptoms include:
Some women may also experience suicidal thoughts, which makes it important to recognise the condition and seek medical help promptly.
Also read: The Menstrual Cycle and Nutrition: Does Your Body Really Need Different Foods at Different Times?
PMS and PMDD are both caused due to hormonal changes in the menstrual cycle. However, the intensity of symptoms and their effects on daily life distinguish the two conditions.
PMS can cause physical and emotional discomfort like bloating, tender breasts, headaches, food cravings, irritability and mood swings in the days leading up to menstruation.
PMDD symptoms can be more severe, especially depression, anxiety, irritability and emotional distress. These symptoms can disrupt work, relationships and everyday functioning.
PMDD is not just an extreme version of a bad premenstrual week. It is a recognised health condition that may require medical treatment.
Experts say that the exact cause of PMDD is not fully understood yet. But they believe it may be due to an increased sensitivity to normal hormonal changes during the menstrual cycle.
After ovulation, levels of hormones like oestrogen and progesterone fluctuate. In some individuals, the brain may respond differently to these hormonal changes, affecting mood regulation and other bodily functions. Serotonin, a neurotransmitter involved in regulating mood, sleep and appetite, may also play a role.
Hailey Bieber's experience has sparked conversation about PMDD risk after childbirth. Pregnancy, childbirth and the postpartum period involve significant hormonal and physical changes.
However, PMDD is linked to the menstrual cycle and its recurring hormonal fluctuations. The return of menstrual cycles after childbirth may make premenstrual symptoms intense. However, there is limited evidence establishing that childbirth directly causes PMDD.
PMDD should also not be confused with postpartum depression. Postpartum depression can occur after childbirth and is not restricted to the days before menstruation. PMDD follows a recurring pattern linked to the menstrual cycle. Its symptoms may generally ease after the period begins.
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Men are beginning to discuss fertility preservation, but the concept of freezing sperm before the age of 35 should not be promoted as something that all young men should undergo. There is no consensus on when men should freeze their sperm; rather, it will depend on their 'personal choice for future childbearing, medical risk, the quality of their sperm and whether, and when, they would be willing to pursue medical assistance or face new circumstances that may limit their options'.
Age still plays a role because male fertility is not entirely age-independent either. Although spermatogenesis persists with age, a prolongation of paternal age is associated with a gradual deterioration in semen parameters and sperm DNA.
A recent 2024 study of 200 turgescent samples from normozoospermic males aged 35 years or less demonstrated DNA fragmentation of 15.
4% in patients of 35 years or less versus 21.7% in patients of 42 years or more. In the older group, host freezing was linked with an increased DNA fragmentation index to 26.7%. This is the reason why sperm freezing upon retrieval at a younger age may have biological benefits.
But the biggest reason for sperm banking is still fertility preservation related medical issues. Men who are diagnosed with testicular cancer, lymphoma, leukaemia or other cancers should ideally freeze sperm before the commencement of chemotherapy, radiotherapy, or possibly fertility-damaging operations and surgery. The 2025 ASCO guideline explicitly urges that fertility preservation be taken into consideration and sperm banking made accessible before cancer therapy.
Men diagnosed with health conditions, receiving medical treatment, or taking drugs that could affect sperm production could also be eligible. Autoimmune diseases, certain systemic diseases, and certain medicines have been reported to interfere with normal sperm production. If testosterone treatment is on a man's agenda, then he should also talk about sperm preservation as a possible option since externally applied testosterone therapy can suppress the body's naturally occurring testosterone levels and, because of this, impair the production of sperm.
Sperm freezing may also be particularly relevant for men with persistently low sperm count or poor sperm motility, especially when these findings are accompanied by elevated follicle-stimulating hormone (FSH) levels. High FSH can indicate impaired testicular function and reduced sperm-producing capacity.
In some men, sperm production may decline further over time, and in severe cases, sperm may become very few or even difficult to retrieve from the ejaculate. Banking sperm when viable sperm are available can therefore provide an additional option for future fertility treatment. The decision should be individualised based on semen parameters, FSH levels, the underlying cause and the advice of a reproductive urologist or fertility specialist.
Also read: The Fertility Side of Metabolic Health: Why Your Waistline May Not Tell the Whole Story
Men who expect to delay parenthood are also showing interest in so-called "elective" or "social" sperm freezing, which is done when it's not related to any medical condition or infertility. It would be the right choice mostly for those men who would not be able or are not sure to get married or to have kids soon, who are exposed to occupational factors endangering fertility, or who want to have a medical treatment that might negatively affect their fertility.
A major 2025 registry analyzing 7,044 men undergoing sperm bank over 30 years indicated an average age at cryopreservation of around 33.1 years, whereas those between 3540 were among the ones most often coming back to take their samples from the freezer.
Importantly, freezing sperm is not the same as guaranteeing a future baby. A 2023 study of 7,969 donor-oocyte cycles found broadly comparable outcomes using fresh and cryopreserved sperm, although fertilisation was marginally lower with frozen sperm after adjustment, 73.66% versus 74.65%.
So, before 35, sperm freezing is best viewed as an option for selected men, not a compulsory fertility insurance policy. Anyone considering it should first undergo a semen analysis and counselling with a reproductive urologist or fertility specialist, particularly if there is a medical, genetic or reproductive risk.
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With infertility affecting an estimated one in six couples, experts at the Times Network India Health Summit 2026 spoke about the importance of seeking timely reproductive health advice and acquiring awareness about treatment options.
They discussed how advancements in fertility treatment have improved the chances of conception, but in vitro fertilisation (IVF) cannot guarantee a pregnancy.
During a panel discussion titled “The Fertility Revolution: Reimagining Parenthood in Modern India,” experts also examined how technology is shaping fertility care, while focusing on the limits of treatment, the cost of repeated IVF cycles and the dire need to address stigma around infertility.
Dr. Hrishikesh Pai, Founder and Managing Director of Bloom IVF India, spoke about the improvement in IVF outcomes over the past three decades. “When I started my own area in 1990, the success rate was 5%. Now it has gone to 30%,” he said.
Pai also spoke about the expansion of India's fertility treatment sector, saying the country had moved from an emerging field to one with centres capable of matching international units in performance.
Technology is also fueling more possibilities in reproductive treatment. Pai discussed the use of artificial intelligence (AI) to assist with embryo selection, egg assessment and sperm identification, alongside emerging techniques like robotic-assisted microinjection.
However, Dr. Abha Majumdar, Emeritus Consultant in IVF and Human Reproduction at Sir Ganga Ram Hospital, cautioned against allowing these advances and spoke about the importance of maintaining unrealistic expectations.
“IVF is not a miracle,” she said, emphasising that patients should receive accurate information about likely outcomes and the limitations of treatment.
Majumdar also raised concerns about AI-generated advertisements promising successful IVF cycles. She stressed that technological progress does not remove the responsibility to communicate treatment outcomes honestly and compassionately.
For couples considering parenthood later in life, understanding age-related fertility decline is important. Dr. Ranjana Sharma, Senior Consultant in Obstetrics and Gynaecology at Indraprastha Apollo Hospital, explained that women are born with a finite supply of eggs, which declines over time.
She highlighted the need for greater awareness of reproductive timing and the options available to people who plan to delay pregnancy.
Majumdar also discussed reproductive autonomy, noting that women increasingly have the freedom to decide when, or whether, to have children. However, she cautioned against viewing egg freezing as a guarantee of future pregnancy, describing it instead as a form of insurance.
Fertility preservation may also be relevant for people facing medical treatments that could affect their reproductive potential. Pai highlighted egg freezing before chemotherapy or radiation therapy as an option for some women who wish to preserve the possibility of having children later.
Sperm freezing can similarly help some men preserve fertility before cancer treatment or in circumstances where future fertility may be a concern.
Even when treatment is available, its cost can be anobstacle. Some patients require more than one IVF cycle, making the overall expense staggering.
Majumdar warned that repeated treatment can become expensive for some families. Although access to fertility services and insurance coverage have improved, affordability remains an important concern.
She also emphasised that patients need realistic information before beginning treatment, including an understanding that one cycle may not result in pregnancy.
Dr. Vimal Grover, who spoke about rising infertility and changing reproductive patterns, identified delayed marriage and childbearing, along with work-related stress, among the factors she had observed. She also pointed to AI's potential role in transforming fertility care.
“One in six couples is infertile,” Grover said. The figure highlights the scale of the infertility crisis in the country.
The panel also addressed the tendency to blame women when couples experience difficulty conceiving. Sharma said women are often held responsible for infertility, even though reproductive difficulties can involve either partner. She also said that fertility specialists increasingly make a point of consulting both partners to encourage shared responsibility for getting tested and treated.
Pai similarly emphasised the importance of evaluating male fertility. Alongside sperm freezing before chemotherapy or radiation therapy, he highlighted its relevance for men with low sperm counts and some patients who may need fertility treatment in the future.
The experts urged couples experiencing difficulties conceiving to seek medical advice rather than feel ashamed or assume that infertility is solely a woman's concern.
The panel was part of the Times Network India Health Summit 2026, held in New Delhi under the theme “The Blueprint for a Future-Ready Healthcare Ecosystem – Innovation. Access. Self-Reliance.” The summit brought together healthcare leaders, clinicians, researchers, policymakers and industry stakeholders to discuss the future of India's healthcare system.
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