Neonatal mortality remains a major health challenge across the world, which involves neonatal sepsis and other related factors of prematurity. Though many strides have been done in reducing NMR, there is a need for more appropriate interventions and strategies directed towards addressing the rise in the escalation of AMR. Combating AMR will be critical in improving neonatal survival rates while giving each newborn a healthier start into life globally.

The newborn period is the key period for infant health, and the first 28 days of life are critically important-both for survival and as a base to set lifetime health and development. Neonatal deaths globally have witnessed a significant decline over the past couple of decades. The neonatal mortality count has significantly reduced dropping from a high of 5 million in 1990 to as low as 2.3 million as of 2022. However, this decline notwithstanding, neonatal mortality is still staggeringly high across low-and middle-income nations.

Neonatal mortality rates are 22 per 1000 live births in India. Neonatal sepsis and prematurity are the main causes of neonatal deaths in these tragic events. Recognizing the gravity of the issue the Indian government started the Indian Newborn Action Plan (INAP) in 2014. The goal is to take NMR down to the single digits by 2030. This initiative has brought in several key interventions, including antenatal care (vaccines, micronutrient supplementation), skilled birth attendance, clean birth practices, and neonatal resuscitation techniques. More promisingly, postnatal interventions, including early initiation of breastfeeding and skin-to-skin contact, have been proven to work well in improving newborn survival rates.

Despite these improvements, one of the biggest concerns in neonatal care today is the growing problem of antimicrobial resistance (AMR) which seriously threatens efforts to reduce neonatal mortality.

What is Antimicrobial Resistance?

Antimicrobial resistance occurs when microorganisms such as bacteria, viruses and fungi evolve over time and become resistant to commonly used antibiotics and other medications. This resistance makes infections more difficult to treat, increasing the risk of mortality and complicating treatment options. The World Health Organization has classified AMR as one of the most urgent global health threats since it not only causes death and disability but also places immense pressure on healthcare systems, significantly raising the economic burden.

The sources of AMR are many, including poor hygiene and infection control in healthcare settings, overuse and misuse of antibiotics. Contributing factors to this rapidly growing problem are antibiotic prescriptions for patient needs that do not require them and failure to complete antibiotic courses, as prescribed.

AMR and Newborn Health

For neonates, the risk is much more vital for AMR. Neonates are particularly prone to developing infections due to their rather weak immune systems. Neonatal sepsis, severe bacterial infection, is one of the leading causes of neonate deaths and it often manifests complications when it is because of drug-resistant pathogens.

According to Dr. Apoorva Taduri, Consultant Neonatologist, "Neonatal sepsis accounts for a significant proportion of neonatal deaths, and AMR is making it worse. MDR pathogens cause around 30% of neonatal sepsis mortality globally.

Maternal health and care are also factors influencing AMR in neonates. Over-prescription of antibiotics during pregnancy increases the risk of neonatal sepsis and the development of multi-drug-resistant pathogens in newborns. This calls for prudent use of antibiotics during pregnancy and at the time of delivery. In fact, studies indicate that indiscriminate use of antibiotics in mothers has a direct impact on neonatal health, which may eventually lead to resistant infections in newborns.

One of the major issues is that the drug-resistant bacteria are causing an increasing number of healthcare-associated infections in the neonatal care settings, which include NICUs. Infections by such bacteria prove to be challenging to treat; they require more advanced, expensive interventions, and the period of risk of mortality and morbidity is extended.

Counteracting AMR in Neonatal Care

To combat AMR and reduce neonatal mortality a multifaceted approach is necessary. Dr. Taduri emphasizes the continuation of the strategies outlined by the Indian Newborn Action Plan (INAP), specifically in reducing neonatal sepsis and improving infection control. However, to combat AMR more must be done to ensure proper use of antibiotics in both maternal and neonatal care settings.

Key strategies for reducing AMR in neonatal care are:

1. Improving Infection Prevention Practice: This implies, therefore, that more efforts would be made regarding stricter hospital hygiene standards, strict equipment sterilization after its usage and even maintaining adequate hand hygiene. Enhanced infection control practices greatly impact minimizing AMR pathogens distribution.

2. Antibiotic Stewardship- Teaching the healthcare providers how not to use antibiotics is a crucial thing in preventing overuse prescription. Antibiotic stewardship programs are designed to promote use of antibiotics only when truly required; appropriate drug, dose and length of treatment should be taken.

3. Improved access to WASH: Access to clean water and sanitation is a fundamental aspect of preventing infections in mothers and newborns. WASH interventions such as clean birthing practices, can reduce the risk of neonatal sepsis due to unsanitary conditions.

4. Maternal Health Strengthening: Proper maternal care, such as proper vaccination, antenatal steroids, and supplementation of micronutrients, can reduce the risk of prematurity and neonatal infection. Prevention of infection in mothers is the first step towards prevention of infection in newborns.

5. Early Diagnosis and Treatment: Early identification and treatment of neonatal infections are very important. This includes proper screening for sepsis and the use of appropriate antibiotics based on the local resistance patterns. It also involves ensuring that infants receive adequate neonatal care, such as those provided in Special Newborn Care Units (SNCUs).

The rise of antimicrobial resistance is a global health challenge that requires urgent action. Combating AMR requires a coordinated effort from governments, healthcare systems and communities worldwide. In neonatal care, addressing AMR is essential to further reducing neonatal mortality rates and ensuring that every newborn has the opportunity to thrive.

As Dr. Taduri concludes, "While we have made substantial progress in reducing neonatal mortality, the emerging risk of antimicrobial resistance creates a major challenge for our efforts. Combating AMR requires a global collective effort, with priorities on infection prevention, responsible use of antibiotics, and enhancement of healthcare practices to ensure a healthier future for all newborns."

Dr Apoorva Taduri is a Consultant Neonatologist at Fernandez Hospital

Pregnancy is often considered to be a journey that begins with a positive pregnancy test. But medical experts agree that the foundation of a healthy pregnancy is laid much earlier, through preconception care, and strengthened throughout pregnancy with consistent antenatal care. The two stages together are important for the health and well-being of both mother and baby.

Preparing for Parenthood Before Conception (Preconception Care): Why it's important.

Preconception care is the care that happens before a woman becomes pregnant. It involves identifying and managing medical, nutritional and lifestyle factors that may affect pregnancy outcomes. If you’re planning a pregnancy or thinking about getting pregnant in the near future, it’s a good idea to prepare your body in advance to help lower the risk of complications. This is especially important considering that 40–50% of pregnancies worldwide are estimated to be unintended, according to the World Health Organization (WHO).

A preconception health check-up will usually include a review of your medical history, screening for chronic conditions such as diabetes, hypertension, thyroid disorders and anemia, assessment of your vaccination status and discussion of any medications that may not be safe during pregnancy. Doctors also advise women to start taking folic acid supplements at least a month before they conceive to help prevent neural tube defects in the developing baby.

And the healthy lifestyle choices are equally important. Maintaining an ideal weight, following a balanced diet, engaging in regular physical activity, avoiding tobacco and alcohol, and managing stress can improve fertility and contribute to a healthier pregnancy.

Every Check-Up Counts (Antenatal care)

Antenatal care should be routine once pregnancy is confirmed. These regular medical visits allow healthcare providers to monitor the growth and development of the baby and watch the mother’s physical and emotional health. WHO recommends at least 8 antenatal contacts. The guideline was increased from four visits to eight contacts during pregnancy to improve maternal and newborn outcomes and reduce preventable stillbirths.

Blood pressure, weight, blood and urine tests, ultrasound scans and fetal growth are regularly checked during routine antenatal appointments. These tests help to identify potential problems such as gestational diabetes, preeclampsia, anemia, or restrictions in fetal growth early on so that treatments can be given in a timely manner.

Antenatal care also gives valuable advice on nutrition, exercise, sleep, mental well-being, breastfeeding preparation and identifying warning signs that require immediate medical attention. Most importantly, it reassures expectant parents and helps to address concerns throughout pregnancy.

Pregnancy care is not just the expectant mother's responsibility. Partners and families can play an important role in providing a supportive environment, encouraging healthy habits, attending medical appointments when able, and providing emotional support. Having a supportive system can help to lower stress levels and improve maternal mental health, which can contribute to better pregnancy outcomes.

As awareness grows, health care providers are encouraging couples to think beyond the baby bump and prioritize health even before pregnancy begins. With advance planning, regular medical care, fact-based lifestyle choices and prompt treatment, when necessary, you can make a real difference and help ensure that pregnancy is a safer and healthier experience for mother and child.

(Dr. Roli Banthia, Consultant- Obstetrics and Gynaecology, Yatharth Super Speciality Hospital, Noida Extension)

Riya and Karan (name changed), both working professionals from Indirapuram, Ghaziabad, often unwind at night by watching reels after putting their 6-year-old son, Aarav, to bed. What began as “just 20 minutes” regularly stretched to 1–2 hours. Over time, Aarav started asking for the phone at dinner. Soon, he insisted on watching reels before sleeping. Tantrums increased when the phone was taken away.

Within months, Aarav’s sleep was delayed by 1–1.5 hours. He woke up cranky and tired for school, and schoolteachers noticed a reduced attention span. He became impatient and easily irritable. His parents realized he was not just watching — he was hooked on fast-paced short videos.

What Is Happening?

Do you know that our children mirror parental behavior? Fast, high-stimulation reels overstimulate the brain. Night screen exposure disrupted melatonin and sleep cycles. Reduced parent-child interaction impacted emotional regulation. We need to understand that sleep is not a passive state of rest; it is an active biological process that is essential for physical growth, brain development, emotional regulation, and overall well-being. In children, adequate and high-quality sleep is as important as proper nutrition and immunization. Unfortunately, pediatric sleep is often neglected, misunderstood, or sacrificed in modern lifestyles.

What Is Normal Pediatric Sleep?

Normal sleep varies with age and follows predictable developmental patterns.

• Newborns (0–3 months): 14–17 hours per day, fragmented into multiple sleep periods.
• Infants (4–12 months): 12–16 hours, with gradual consolidation of night sleep.
• Toddlers (1–2 years): 11–14 hours, including 1–2 daytime naps.
• Preschool children (3–5 years): 10–13 hours, often with one nap.
• School-age children (6–12 years): 9–12 hours, usually no naps.
• Adolescents (13–18 years): 8–10 hours, with a natural tendency toward later sleep and wake times.

Normal sleep is regular, age-appropriate in duration, refreshing, and uninterrupted, allowing the child to wake up alert and active during the day.

How To Promote Normal Sleep In Children

Healthy sleep habits, often referred to as sleep hygiene, are the cornerstone of normal pediatric sleep.

Key strategies include:

• Maintaining a fixed bedtime and wake-up time, even on weekends.
• Establishing a calm and predictable bedtime routine (bath, reading, prayer, or quiet conversation).
• Ensuring the sleep environment is dark, quiet, cool, and comfortable.
• Avoiding screen exposure (mobile phones, tablets, television) at least 1–2 hours before bedtime.
• Encouraging daytime physical activity and exposure to natural daylight.
• Avoid heavy meals, caffeine, or sugary drinks close to bedtime.
• Consistency is critical. Children thrive on routine, and predictable sleep schedules reinforce the body’s internal clock.

Home Remedies to Support Better Sleep

Simple, non-pharmacological measures at home can significantly improve sleep quality:

• Warm bath or gentle massage before bedtime to promote relaxation.
• Storytelling or reading can help transition from stimulation to calmness.
• Soft music or white noise for children who have difficulty settling.
• Comfort objects (a favorite toy or blanket) for younger children.
• Teaching relaxation techniques such as deep breathing to older children.
• Limiting late-evening academic pressure or emotionally charged discussions.

Importantly, sleeping pills or sedatives should never be used without medical advice.

Why Sleep Is Crucial for Growth and Development

Sleep plays a central role in nearly every aspect of child development:

• Growth hormone secretion peaks during deep sleep, directly influencing height and physical development.
• Brain maturation and learning depend on sleep for memory consolidation and neural connectivity.
• Immune function is strengthened during sleep, reducing infection risk.
• Emotional regulation improves with adequate sleep, reducing irritability and mood swings.
• Metabolic health is protected, lowering the risk of obesity and insulin resistance.

Chronic sleep deprivation disrupts these processes, with long-term consequences.

Common Pediatric Sleep Disorders

Pediatric sleep disorders are common and often under-recognized. They include:

• Behavioral insomnia of childhood (difficulty falling or staying asleep due to habits).
• Sleep-disordered breathing, including obstructive sleep apnea.
• Parasomnias such as night terrors, sleepwalking, and confusional arousals.
• Restless sleep disorders, including restless legs syndrome.
• Circadian rhythm disorders are particularly prevalent in adolescents.
• Early recognition and treatment are essential to prevent secondary behavioral and academic problems.

Relationship Between Sleep and Behavioral Disturbance

There is a strong and well-established link between poor sleep and behavioral issues in children.

Sleep-deprived children may present with:

• Hyperactivity and impulsivity (often mimicking ADHD)
• Inattention and poor academic performance
• Irritability, aggression, and emotional outbursts
• Anxiety and depressive symptoms
• Poor social interaction and reduced empathy

Future Consequences: Sleep, Aggression, and Crime

The long-term consequences of untreated sleep disorders extend beyond childhood:

• Chronic sleep deprivation affects impulse control, judgment, and emotional regulation.
• Adolescents with persistent sleep problems show higher rates of risk-taking behavior, substance use, and aggression.
• Longitudinal studies suggest associations between poor childhood sleep, antisocial behavior, and later involvement in violence or crime.
• Sleep deprivation impairs moral reasoning and increases reactive aggression, particularly in socially vulnerable populations.

Healthy sleep is a foundational pillar of pediatric health, equal in importance to nutrition, education, and emotional security. Promoting normal sleep from early childhood can improve behavior, academic success, mental health, and even societal outcomes in adulthood. Parents, schools, and healthcare providers must work together to recognize sleep as a priority—not a luxury—for every child.

Early investment in healthy sleep is an investment in healthier individuals and a safer society.

(By Dr Tanuj Kumar Verma, Consultant, Pediatric Intervention Pulmonologist and Intensivist at Cloudnine Group of Hospitals, Indirapuram)

A new study published in The Lancet Obstetrics, Gynaecology, & Women's Health has revealed an alarming rise in infertility rates among women aged 35 years and older.

The analysis, based on the Global Burden of Disease Study 2023, found that global female infertility could affect nearly 80 million women aged 35–49 by 2036 if current trends continue.

In 2023, an estimated 53.60 million women aged 35–49 were affected by infertility. Nearly 54 million women in this age group sought fertility care, including fertility testing and assisted reproductive technologies such as in vitro fertilization (IVF).

Asia Bears Highest Burden

According to the study, Asia has the highest need for fertility care particularly East Asia reported the highest regional burden, while Australasia has the lowest. At country level, the Central African Republic had the highest reported burden, while Nepal had the lowest.

Although disparities between low- and high-income regions have narrowed, the burden is shifting toward high-income settings, where women are more likely to delay pregnancy and seek fertility testing and treatment.

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The researchers said, "This shift reflects broader social and economic changes, including delayed family planning and greater access to fertility services in some affluent regions".

"Advanced-age female infertility represents a growing global health challenge. Despite improved regional equity, low-SDI countries continue to face significant burdens. This necessitates implementing tailored public health strategies and prioritizing resource allocation to mitigate future burdens," said the researchers from China, Hong Kong, and Singapore in the paper.

To address the rising demand, the authors called for

• expanding and integrating fertility services into primary health care, reducing financial barriers to treatment,
• using innovative delivery methods,
• mobile health tools,
• improve equitable access to fertility care.

Infertility A Growing Global Health Concern

The World Health Organization defines infertility as the failure to achieve a clinical pregnancy after 12 months of regular unprotected intercourse.

Approximately 8–12 per cent of reproductive-aged couples worldwide experience infertility, with the burden disproportionately affecting women aged 35–49 years.

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The study noted that this higher risk is largely biological, driven by age-related declines in ovarian reserve and oocyte quality, which reduce natural fertility, increase miscarriage risk, and lower the success rates of assisted reproductive technologies (ART).

As populations age and socioeconomic transitions continue, the number of women exposed to advanced-age infertility risk is increasing, making it an increasingly important public health issue.

How Was The Study Conducted?

The researchers analyzed data from the Global Burden of Disease (GBD) 2023 study to provide what they describe as the first comprehensive assessment of infertility among women aged 35–49 across 204 countries and territories.

Since 1990, both the age-standardized prevalence rate and disability-adjusted life years (DALYs) attributable to infertility have risen steadily, by 0.45 per cent and 0.47 per cent every year, respectively.

The study projects that infertility cases in women aged 35–49 will continue to rise, reaching nearly 80 million by 2036 in the absence of targeted interventions.

The researchers also found a 23.10% reduction in the relative disparity in infertility-related DALYs between low- and high-Socio-demographic Index (SDI) regions since 1990, indicating progress in equity while highlighting persistent structural gaps in access to care.