A revolutionary study published in BJPsych Open has revealed compelling evidence that a ketogenic diet can have a major impact on mental and physical well-being in bipolar disorder patients. The study, conducted by Dr. Iain Campbell, PhD, Baszucki Metabolic Psychiatry Research Fellow at the University of Edinburgh, investigates how a metabolic-based intervention might represent an exciting new strategy for treating this serious mental illness.
The research is the first in Europe to use neuroimaging methods, namely magnetic resonance spectroscopy (MRS), to investigate changes in brain metabolism in people with bipolar disorder after a ketogenic diet. The imaging findings revealed decreases in excitatory neurotransmitters, which are normally increased in bipolar disorder. This indicates that the ketogenic diet can stabilize brain activity, possibly reducing mood swings and other symptoms of the condition.
The trial involved 27 participants diagnosed with bipolar disorder, 20 of whom successfully completed the 6-8 week program. A staggering 91% of these individuals maintained ketosis, the metabolic state where the body primarily burns fat for energy instead of carbohydrates. Those who provided consistent daily ketone and mental health assessments reported notable improvements in mood, energy levels, anxiety, and impulsivity.
Dr. Campbell, who personally adheres to a ketogenic diet himself in order to treat symptoms of bipolar disorder, discussed the importance of these results:
"We saw indicators of diminished excitotoxicity in the brain regions most implicated in bipolar disorder. These findings are consistent with the metabolic overdrive hypothesis that postulates energy dysregulation within the brain as central to the disorder. Treating the dysregulation by means of a ketogenic diet could be a game-changer in treatment-resistant patients.
Aside from the scientific evidence, personal accounts of study participants underscore the life-altering effect of a ketogenic diet.
"Quite literally, for the first time in years, I felt like my brain was finally fueled correctly," explained a participant.
Another participant called the diet "a lifeline, restoring my energy and sense of hope. I felt like I was finally healing my mind, not just coping with my bipolar symptoms."
One of the very vivid accounts described the impact of ketosis in terms of a relaxing mental atmosphere:
"Applying a ketogenic diet is akin to giving my mind a nice warm bath. The edginess disappears. I am more calm, more clear, and my brain function is restored again."
Aside from the psychological benefits of the study, the ketogenic diet was also seen to have beneficial effects on participants' physical health. Nineteen out of the 20 trial completers lost a total of 9.3 pounds (4.2 kg) on average and showed improvements in body mass index (BMI) and blood pressure.
These results are noteworthy in that numerous treatments for bipolar disorder, such as mood stabilizers and antipsychotic medications, have been linked to metabolic side effects of weight gain and risk of cardiovascular disease. In contributing to the reduction of such risks, a ketogenic diet may provide a double dividend for patients with bipolar disorder.
Although the ketogenic diet has previously been known largely for its utility in treating epilepsy that is treatment-resistant, it is a somewhat new area to explore in conditions of psychiatry such as in bipolar disorder. It has come to be known that metabolic imbalance is an underlying factor in causing psychiatric disorders as energy production deficiencies have been recognized to contribute towards neural excitability and mood disruption.
One of the important findings of the study is that people with bipolar disorder tend to have sodium levels higher than usual within their cells. Lithium, a standard mood stabilizer, acts partly by reducing these sodium levels. The ketogenic diet seems to do the same thing, offering a metabolic explanation for its beneficial effect on mood stabilization.
The ketogenic diet is a high-fat, low-carb diet that changes the body's main source of energy from glucose to ketones. As carbohydrate consumption is significantly decreased, the liver breaks down fats into ketones, which can be used as a substitute fuel by the brain and body.
First developed in the 1920s as a therapy for epilepsy, the ketogenic diet has been researched for its therapeutic applications in a variety of neurological and psychiatric disorders, including Alzheimer's disease, Parkinson's disease, and most recently, bipolar disorder.
There's a critical need for bigger replication studies and well-designed randomized clinical trials to follow up on these findings," added Dr. Campbell. "Our findings indicate that a ketogenic diet may be a useful adjunctive treatment for bipolar disorder, bringing new promise to patients who have difficulty with standard therapies.
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As the United States Department of Justice continues to release the harrowing Epstein Files that lift the lid on years' worth of horrific crimes by the convicted American child sex offender, serial rapist and human trafficker, eagle eyed readers have noticed a unique breakfast item in the documents.
In a file titled 'J.E.E Operating Manual', experts found a 11-step muffin recipe named 'J.E.E. Muffin Recipe' that the felon insisted should be served to him every morning at 6.30am.
The Epstein files are over six million pages of documents, images and videos detailing the criminal activities of the financier and his social circle of public figures that included politicians and celebrities.
His co-conspirator Ghislaine Maxwell, who is also a convicted child sex trafficker and sometimes referred to as the "Lady of the House" is serving a 20-year prison sentence at a minimum-security prison camp in Texas.
To start off, the recipe involves 12 ingredients which are:
1. In a large bowl combine bran, flour, flax seeds, baking soda and salt
2. Beat eggs and sugar in the bowl of an electric mixer until thick and creamy.
3. Add oil to egg/sugar mixture and mix to combine. Also combine milk and vanilla and set aside.
5. Add flour and milk mixtures to egg/sugar mixture, alternating additions until combined. Do not over beat mixture.
6. Add raisins and stir until incorporated.
7. Pour mixture into an airtight plastic container and store in the refrigerator for 24 hours before using.
8. Grease large muffin tin with Pam Spray.
9. Fill tins to the top with mixture and top with chopped nut/sugar/flax .
10. Bake at 350 degrees F. for 35-45 minutes.
11. Combine chopped pecans, walnuts and almonds, wheat germ, flax seeds and brown sugar for muffin toppings
While public speculation runs rampant over why this digestion-friendly muffin recipe was a critical part of Epstein's daily routine, as many allege and theorize that it was fed to the children on his island, nutritionists claim that this bran-packed muffins can help your body in multiple ways.
Dr. Anshul Singh, Team Lead, Clinical Nutritionist, Artemis Hospitals noted that this baked good is packed with tons of fiber, omega-3, iron and antioxidants, all of which are extremely beneficial for the body.
He tells Healthandme: "People often call this muffin recipe a high-fiber muffin and it is good for your health in small amounts. The fact that this recipe has a lot of fiber is its best quality.
"Digestive bran, whole wheat flour, ground flaxseed and whole flax seeds are all high in dietary fiber. Fiber helps with bowel movements, constipation and overall gut health. Fibre makes stool thicker which makes digestion easier and more regular.
"Flaxseeds also have omega-3 fatty acids which can lower inflammation and improve heart health. Raisins add natural sweetness, iron and antioxidants while eggs and milk add protein that keeps you full longer. Olive oil has healthy fats that help with digestion and the absorption of vitamins that dissolve in fat.
"These muffins might help people who have trouble with slow digestion or irregular bowel movements, especially if they drink enough water with them. But calling them detox or clean-out foods can be misleading. The liver and kidneys are two of the body's organs that help get rid of toxins. The fiber in these muffins is what really helps the digestive system work better.
"The recipe has a lot of sugar and fiber, so it's important to watch how much you eat. A muffin can be a filling, easy-to-digest snack instead of a cure-all."
However, Zoha Shaikh, Consultant Nutritionist at Nutriiya, warns that these muffins may also cause stomach issues including bloating, gas, acid reflux and diarrhea.
She told this publication: "This muffin recipe is rich in fibre and may help relieve constipation in individuals with low fibre intake. However, the combination of very high fibre, sugar, and milk can also trigger bloating, gas, abdominal cramping, loose stools and acid reflux especially in sensitive individuals.
"The high use of baking soda contributes to increased sodium load, making it unsuitable for people with hypertension. From a clinical nutrition perspective, replacing wheat bran with oat bran, reducing baking soda, moderating flaxseed quantity and adding psyllium husk can make the recipe more gut-friendly. Eggs and psyllium together also improve texture and fluffiness while being gentler on digestion."
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February often feels like winter’s longest stretch. The days are short, the sun rarely breaks through the clouds, and many people find themselves feeling unusually tired or low. Health experts say this is also the time of year when vitamin D deficiency tends to surface, especially in regions with limited winter sunlight.
While vitamin D is best known for its role in bone health, its impact goes far beyond that. As sunlight exposure drops in late winter, attention is turning to how diet can help support the body until brighter days return.
Vitamin D plays a key role in several essential functions. It helps the body absorb calcium, which is crucial for maintaining strong bones and teeth. It also supports normal muscle function and keeps the immune system working efficiently.
What is less widely discussed is its role in brain health. Vitamin D receptors are present in many areas of the brain, and low levels have been linked to changes in mood and energy. During winter, many people report feeling sluggish, unmotivated, or emotionally flat. While these symptoms are often blamed on stress or lack of sleep, reduced sunlight and falling vitamin D levels may also contribute.
The body produces most of its vitamin D when the skin is exposed to sunlight. In winter, shorter days, heavy clothing, and more time spent indoors mean that this natural process slows down significantly. Even people who eat well can struggle to maintain optimal levels during prolonged periods of low sun exposure.
This is where food choices can offer some support, even if they cannot fully replace sunlight.
Salmon is one of the richest natural sources of vitamin D. It also provides high quality protein and healthy fats that support heart and brain health. Simple meals like oven baked salmon with potatoes and broccoli or a salmon rice bowl with vegetables make it easy to include in weekly meals.
Herring is another strong option. It contains both vitamin D and omega 3 fatty acids, which are known to support heart health. Traditional combinations such as herring with boiled potatoes or a light yogurt based sauce are both nourishing and filling.
Eggs also contribute small amounts of vitamin D, mainly from the yolk. While they do not provide as much as fatty fish, they are easy to include in daily meals. Scrambled eggs, vegetable omelettes, or a soft boiled egg at dinner can all help increase intake over time.
Mushrooms are one of the few plant based foods that contain vitamin D, especially when they have been exposed to light. They are not a replacement for fish but can be a helpful addition for those who eat little or no seafood.
Nutrition can support vitamin D levels during winter, but it cannot fully make up for the lack of sunlight. Most vitamin D is still produced through the skin, not the diet. Experts advise making the most of daylight when possible, even short walks outdoors, while using food as a supportive measure until spring arrives.
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Recent insights from medical experts show that even people who eat very less can gain weight due muscle mass, stress, and their body’s movement during the day.
Dr Mohit Bhandari, a robotic bariatric and endoscopic weight loss surgeon, founder and director of Mohak Bariatrics and Robotics at Bhandari Hospital Indore notes some people eat whatever they want without gaining weight, while others struggle even with dieting.
The secret lies in the complex interplay of genetics, metabolism, and environmental factors that influence weight management.
This is why are you are putting on weight, according to Dr Bhandari:
The speed at which the body burns calories is different for every individual. A slower metabolism means that even consuming small amount of food can lead to gain.
Individuals with high level of physical activity are less likely to be obese as they mean calories quicker.
Hormones like thyroid hormones, cortisol, and play a major role in weight regulation. Stress, lack of sleep and Insulin sensitivity are also factors that lead to fat storage in the body.
Consuming a snack rich in carbohydrate with 10-20 grams of protein before and immediately after strength training sessions further acts as a responsible factor in gaining weight.
Additionally, it can also trigger inflammation, which interferes with normal metabolism and insulin function, encouraging fat storage.
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