A revolutionary study published in BJPsych Open has revealed compelling evidence that a ketogenic diet can have a major impact on mental and physical well-being in bipolar disorder patients. The study, conducted by Dr. Iain Campbell, PhD, Baszucki Metabolic Psychiatry Research Fellow at the University of Edinburgh, investigates how a metabolic-based intervention might represent an exciting new strategy for treating this serious mental illness.

The research is the first in Europe to use neuroimaging methods, namely magnetic resonance spectroscopy (MRS), to investigate changes in brain metabolism in people with bipolar disorder after a ketogenic diet. The imaging findings revealed decreases in excitatory neurotransmitters, which are normally increased in bipolar disorder. This indicates that the ketogenic diet can stabilize brain activity, possibly reducing mood swings and other symptoms of the condition.

The trial involved 27 participants diagnosed with bipolar disorder, 20 of whom successfully completed the 6-8 week program. A staggering 91% of these individuals maintained ketosis, the metabolic state where the body primarily burns fat for energy instead of carbohydrates. Those who provided consistent daily ketone and mental health assessments reported notable improvements in mood, energy levels, anxiety, and impulsivity.

Dr. Campbell, who personally adheres to a ketogenic diet himself in order to treat symptoms of bipolar disorder, discussed the importance of these results:

"We saw indicators of diminished excitotoxicity in the brain regions most implicated in bipolar disorder. These findings are consistent with the metabolic overdrive hypothesis that postulates energy dysregulation within the brain as central to the disorder. Treating the dysregulation by means of a ketogenic diet could be a game-changer in treatment-resistant patients.

Aside from the scientific evidence, personal accounts of study participants underscore the life-altering effect of a ketogenic diet.

"Quite literally, for the first time in years, I felt like my brain was finally fueled correctly," explained a participant.

Another participant called the diet "a lifeline, restoring my energy and sense of hope. I felt like I was finally healing my mind, not just coping with my bipolar symptoms."

One of the very vivid accounts described the impact of ketosis in terms of a relaxing mental atmosphere:

"Applying a ketogenic diet is akin to giving my mind a nice warm bath. The edginess disappears. I am more calm, more clear, and my brain function is restored again."

Aside from the psychological benefits of the study, the ketogenic diet was also seen to have beneficial effects on participants' physical health. Nineteen out of the 20 trial completers lost a total of 9.3 pounds (4.2 kg) on average and showed improvements in body mass index (BMI) and blood pressure.

These results are noteworthy in that numerous treatments for bipolar disorder, such as mood stabilizers and antipsychotic medications, have been linked to metabolic side effects of weight gain and risk of cardiovascular disease. In contributing to the reduction of such risks, a ketogenic diet may provide a double dividend for patients with bipolar disorder.

Link Between Metabolism and Bipolar Disorder

Although the ketogenic diet has previously been known largely for its utility in treating epilepsy that is treatment-resistant, it is a somewhat new area to explore in conditions of psychiatry such as in bipolar disorder. It has come to be known that metabolic imbalance is an underlying factor in causing psychiatric disorders as energy production deficiencies have been recognized to contribute towards neural excitability and mood disruption.

One of the important findings of the study is that people with bipolar disorder tend to have sodium levels higher than usual within their cells. Lithium, a standard mood stabilizer, acts partly by reducing these sodium levels. The ketogenic diet seems to do the same thing, offering a metabolic explanation for its beneficial effect on mood stabilization.

What Is a Ketogenic Diet?

The ketogenic diet is a high-fat, low-carb diet that changes the body's main source of energy from glucose to ketones. As carbohydrate consumption is significantly decreased, the liver breaks down fats into ketones, which can be used as a substitute fuel by the brain and body.

First developed in the 1920s as a therapy for epilepsy, the ketogenic diet has been researched for its therapeutic applications in a variety of neurological and psychiatric disorders, including Alzheimer's disease, Parkinson's disease, and most recently, bipolar disorder.

There's a critical need for bigger replication studies and well-designed randomized clinical trials to follow up on these findings," added Dr. Campbell. "Our findings indicate that a ketogenic diet may be a useful adjunctive treatment for bipolar disorder, bringing new promise to patients who have difficulty with standard therapies.

Sugar is bad for health, and we have heard this several times, on loop. But little do people realise that not all forms of sugar are bad for your body - some sugars are naturally occurring and might actually be the sweet treat you need. Fructose, for instance, found in fruits, is not as bad as processed sugar. But it is still important to know when to stop. In an interview with Health and Me, Dr Nimitt Nagda, Consulting Physician, Zynova Shalby Hospital, Mumbai, explained how natural sugar is different from processed sugar.

What is natural sugar?

Natural sugars present in fruits and milk tend to have nutrients and fibre, while processed sugar often adds empty calories that can harm health when consumed excessively. This article helps to explain how natural sugars impact the body differently when compared to processed sugars. Read on to know more about this and make sure to avoid excess processed sugar. So, adhere to healthy eating habits.

Sugar is a part of many foods that are eaten by people on a daily basis. However, not all sugars affect the body in the same way. Natural sugars are present in foods such as fruits, vegetables, and milk, whereas processed or added sugars are found in sweets, soft drinks, packaged snacks, bakery products, and desserts. While both types provide energy, the body handles them differently. It is the need of the hour to understand the difference between the two, as excessive intake of processed sugar is linked to obesity, diabetes, heart disease, and fatty liver disease. So, be cautious when it comes to your well-being.

Is natural sugar better?

Natural sugars are usually accompanied by fibre, vitamins, minerals, antioxidants, and water content. Fruits contain fructose, but they also provide fibre that slows down sugar absorption into the bloodstream. This helps maintain stable energy levels and prevents sudden spikes in blood sugar. Milk contains lactose along with protein and calcium, making it more nutritionally balanced. When it comes to processed sugar, it is quickly absorbed by the body because it lacks fibre and nutrients. This can lead to rapid increases in blood sugar and insulin levels. Frequent consumption of sugary foods and beverages may increase cravings, weight gain, fatigue, diabetes, obesity, and fatty liver disease. Processed sugar also contributes to inflammation, tooth decay, and unhealthy fat accumulation in the body. Moreover, natural foods are more filling, whereas processed sugary foods often encourage overeating because they do not satisfy hunger for long.

Natural sugars consumed through whole foods like fruits and milk are generally healthier because they come with essential nutrients and fibre that support overall well-being. Processed sugars, when consumed in excess, can negatively affect health and increase the risk of several chronic diseases. Choosing natural food sources and limiting added sugars can help maintain better energy levels, weight control, and long-term health. So, make sure to pay attention to your health without fail and limit processed sugar.

Are you planning to undergo IVF treatment? A healthy thyroid and balanced nutrition are crucial when it comes to improving implantation and supporting a healthy IVF journey. So, make sure to add these three nutrients to conceive successfully and fulfil the dream of motherhood. It is time for women to include these nutrients and focus on their health. Dr Mrunalini Jagne (Ahire), Fertility Consultant and IVF Specialist at Motherhood Fertility & IVF, Kharghar, Navi Mumbai, spoke about the rising incidence of IVF and how thyroid health is just as important for better implantation and IVF results.

Currently, many couples are opting for in vitro fertilisation (IVF). It can be physically and emotionally demanding for couples who wish to conceive. So, for those who are opting for IVF, it is also necessary to check thyroid function and pay attention to diet. Are you aware? An uncontrolled thyroid condition can impact hormone balance, egg quality, implantation, and even increase the chances of miscarriage. Along with regular medical guidance, certain nutrients may help prepare the body for implantation and early pregnancy. Hence, women should add these three nutrients without fail after discussing them with an expert.

Make sure to include these vital nutrients in your diet

1. Folic Acid: This is one of the vital nutrients before and during pregnancy. It supports healthy cell growth and helps in the early development of the baby’s brain and spine. It may also help to enhance egg quality and create a healthier environment for implantation. So, opt for foods such as spinach, broccoli, lentils, citrus fruits, and fortified cereals, which are good sources of folic acid. An expert can also recommend supplements before IVF. So, make sure to take them and stay healthy.
2. Vitamin D: This is necessary for hormone balance, immune function, and reproductive health. Low vitamin D levels are seen in women facing fertility issues and may affect implantation success. Safe sunlight exposure, eggs, dairy products, mushrooms, and fatty fish can be recommended to women to improve their vitamin D levels. However, the doctor may suggest blood tests and supplements if a deficiency is detected.
3. Omega-3 Fatty Acids: These improve blood flow to the uterus and reduce inflammation in the body. They support hormone production and overall reproductive health. Go for foods such as walnuts, flaxseeds, chia seeds, and fish such as salmon, which are rich in healthy fats that may support implantation and pregnancy health.

So, women, make sure to discuss your diet with an expert. A balanced diet, healthy lifestyle, regular medical check-ups, and proper management of thyroid conditions are crucial when it comes to supporting implantation and overall reproductive health. Try to avoid junk, oily, canned, sugary, and processed foods. Small lifestyle changes before IVF can help prepare the body better for pregnancy. So, don’t miss these nutrients and include them as per the expert’s advice.

Food allergy in children is becoming a more visible concern in Indian families, especially in urban settings where children are growing up with a different immune environment from earlier generations.

Less outdoor exposure, smaller families, more indoor living, frequent antibiotic use, air pollution, shifts in gut bacteria, packaged foods, and delayed introduction of certain foods may influence how the immune system learns tolerance. A food allergy happens when the body treats a harmless food protein as a threat and reacts against it.

Misleading Early Symptoms

The difficulty for parents is that many early symptoms look ordinary. Gas, bloating, or loose stools after a food may point to intolerance, which can be uncomfortable but is usually not dangerous.

An allergy tends to follow a more recognizable pattern involving hives, itching, swelling of the lips or eyes, repeated vomiting, coughing, wheezing, throat tightness, breathing difficulty, sudden tiredness or faintness soon after eating. In severe reactions, anaphylaxis can affect breathing and blood pressure, making it a medical emergency.

India adds another layer of complexity because possible triggers are often everyday foods. Milk, wheat, egg, peanut, fish, chickpea, lentils, and sesame are part of a child’s routine diet. Removing them altogether can deprive a growing child of protein, calories, and micronutrients, and ignoring repeated reactions can keep the child exposed to a genuine trigger. Both can harm the child.

What Should Parents Watch For

Parents should watch for patterns rather than fear every meal. If eczema flares, vomiting, wheezing, stomach pain, swelling, or rashes repeatedly appear after the same food, the child’s allergies should be evaluated.

A food diary is useful, but diagnosis cannot rest on home-based trial and error. The most important starting point is a careful clinical history: what was eaten, how quickly symptoms appeared, whether it happened again, and which body systems were involved. Based on this, a doctor may advise a skin prick test, serum-specific IgE test, or, in selected cases, a supervised oral food challenge.

The goal is simple: do not label every discomfort as an allergy, and do not dismiss repeated reactions as weak digestion. Children should remain confident around food while genuine triggers are identified, managed, and nutritionally replaced.