A revolutionary study published in BJPsych Open has revealed compelling evidence that a ketogenic diet can have a major impact on mental and physical well-being in bipolar disorder patients. The study, conducted by Dr. Iain Campbell, PhD, Baszucki Metabolic Psychiatry Research Fellow at the University of Edinburgh, investigates how a metabolic-based intervention might represent an exciting new strategy for treating this serious mental illness.

The research is the first in Europe to use neuroimaging methods, namely magnetic resonance spectroscopy (MRS), to investigate changes in brain metabolism in people with bipolar disorder after a ketogenic diet. The imaging findings revealed decreases in excitatory neurotransmitters, which are normally increased in bipolar disorder. This indicates that the ketogenic diet can stabilize brain activity, possibly reducing mood swings and other symptoms of the condition.

The trial involved 27 participants diagnosed with bipolar disorder, 20 of whom successfully completed the 6-8 week program. A staggering 91% of these individuals maintained ketosis, the metabolic state where the body primarily burns fat for energy instead of carbohydrates. Those who provided consistent daily ketone and mental health assessments reported notable improvements in mood, energy levels, anxiety, and impulsivity.

Dr. Campbell, who personally adheres to a ketogenic diet himself in order to treat symptoms of bipolar disorder, discussed the importance of these results:

"We saw indicators of diminished excitotoxicity in the brain regions most implicated in bipolar disorder. These findings are consistent with the metabolic overdrive hypothesis that postulates energy dysregulation within the brain as central to the disorder. Treating the dysregulation by means of a ketogenic diet could be a game-changer in treatment-resistant patients.

Aside from the scientific evidence, personal accounts of study participants underscore the life-altering effect of a ketogenic diet.

"Quite literally, for the first time in years, I felt like my brain was finally fueled correctly," explained a participant.

Another participant called the diet "a lifeline, restoring my energy and sense of hope. I felt like I was finally healing my mind, not just coping with my bipolar symptoms."

One of the very vivid accounts described the impact of ketosis in terms of a relaxing mental atmosphere:

"Applying a ketogenic diet is akin to giving my mind a nice warm bath. The edginess disappears. I am more calm, more clear, and my brain function is restored again."

Aside from the psychological benefits of the study, the ketogenic diet was also seen to have beneficial effects on participants' physical health. Nineteen out of the 20 trial completers lost a total of 9.3 pounds (4.2 kg) on average and showed improvements in body mass index (BMI) and blood pressure.

These results are noteworthy in that numerous treatments for bipolar disorder, such as mood stabilizers and antipsychotic medications, have been linked to metabolic side effects of weight gain and risk of cardiovascular disease. In contributing to the reduction of such risks, a ketogenic diet may provide a double dividend for patients with bipolar disorder.

Link Between Metabolism and Bipolar Disorder

Although the ketogenic diet has previously been known largely for its utility in treating epilepsy that is treatment-resistant, it is a somewhat new area to explore in conditions of psychiatry such as in bipolar disorder. It has come to be known that metabolic imbalance is an underlying factor in causing psychiatric disorders as energy production deficiencies have been recognized to contribute towards neural excitability and mood disruption.

One of the important findings of the study is that people with bipolar disorder tend to have sodium levels higher than usual within their cells. Lithium, a standard mood stabilizer, acts partly by reducing these sodium levels. The ketogenic diet seems to do the same thing, offering a metabolic explanation for its beneficial effect on mood stabilization.

What Is a Ketogenic Diet?

The ketogenic diet is a high-fat, low-carb diet that changes the body's main source of energy from glucose to ketones. As carbohydrate consumption is significantly decreased, the liver breaks down fats into ketones, which can be used as a substitute fuel by the brain and body.

First developed in the 1920s as a therapy for epilepsy, the ketogenic diet has been researched for its therapeutic applications in a variety of neurological and psychiatric disorders, including Alzheimer's disease, Parkinson's disease, and most recently, bipolar disorder.

There's a critical need for bigger replication studies and well-designed randomized clinical trials to follow up on these findings," added Dr. Campbell. "Our findings indicate that a ketogenic diet may be a useful adjunctive treatment for bipolar disorder, bringing new promise to patients who have difficulty with standard therapies.

For years, weight loss advice has been dominated by a single message: eat less. From crash diets to extreme calorie counting, the assumption has been that consuming fewer calories is the ultimate solution to obesity. While reducing excessive calorie intake can contribute to weight loss, the reality is far more complex. Sustainable weight management requires understanding the science of metabolism, behaviour, hormones, sleep, stress, and long-term lifestyle patterns rather than relying solely on restriction.

Why Restrictive Diets Don't Help

The human body is not a simple mathematical equation. It is an adaptive system designed to protect itself. When calorie intake is drastically reduced, the body often interprets this as a potential threat and responds by slowing metabolism to conserve energy. Hunger hormones such as ghrelin increase, while hormones responsible for satiety decrease. As a result, people often feel hungrier, more fatigued, and less motivated over time.

This explains why many restrictive diets may show short-term success but fail to deliver sustainable outcomes. Initial weight loss is often followed by plateaus or weight regain, leaving individuals frustrated and blaming themselves for lacking discipline. In reality, biology plays a significant role in resisting prolonged calorie deprivation.

Food Quality and Lifestyle Factors

Equally important is the quality of food being consumed. Two meals with the same calorie count can affect the body very differently. Diets rich in processed foods, refined sugars, and unhealthy fats can lead to rapid blood sugar fluctuations, increased cravings, and poor satiety. On the other hand, balanced meals containing adequate protein, fibre, healthy fats, and micronutrients help regulate appetite and support metabolic health.

Lifestyle factors also play a critical role in sustainable weight management. Chronic stress elevates cortisol levels, which may contribute to increased fat storage and emotional eating. Poor sleep disrupts hormones that regulate hunger and fullness, often increasing cravings for high-calorie foods while reducing energy levels for physical activity. Sedentary lifestyles further compound the issue.

Weight loss is also deeply connected to behavioral and emotional health. Many eating habits are influenced by stress, social environments, routines, and emotional triggers rather than true hunger. Advising someone to “just eat less” overlooks these underlying drivers. Without addressing behavioral patterns, sustainable change becomes difficult.

This evolving understanding of obesity has shifted the conversation from blame and willpower to science and personalized care. Today, obesity is increasingly recognized as a chronic, multifactorial condition that requires comprehensive management strategies tailored to individual needs.

Lifestyle modifications such as balanced nutrition, regular physical activity, sleep optimization, and behavioral counselling remain the cornerstone of treatment. However, for some individuals, especially those struggling with obesity-related health concerns or repeated cycles of weight regain, lifestyle interventions alone may not always be sufficient.

Endoscopic Procedures

In recent years, minimally invasive endoscopic procedures have emerged as additional tools within medically supervised weight management programs. Procedures such as endoscopic sleeve gastroplasty (ESG) help reduce stomach volume to promote early satiety, while intragastric balloons can aid portion control and behavioral modification. Transoral outlet reduction (TORe) may also help individuals experiencing weight regain after bariatric surgery.

These procedures are not shortcuts or substitutes for healthy habits. Instead, they work in conjunction with long-term dietary and lifestyle interventions to support sustainable outcomes in appropriately selected patients.

Sustainable Weight Loss

Ultimately, sustainable weight loss is not about punishing the body through extreme restriction. It is about understanding how the body functions, identifying the biological and behavioral factors influencing weight, and creating realistic, long-term strategies that support overall health.

The future of weight management lies not in simplistic advice, but in compassionate, science-backed, and personalized care. Only by moving beyond the outdated “eat less” narrative can we create healthier and more sustainable approaches to obesity management.

(Dr. Saransh Jain, Consultant Gastroenterology at the BLK Super Speciality hospital)

India's food regulator, FSSAI, has issued notices to six beverage brands, including Red Bull and PepsiCo India, for claiming to be "energy drinks," citing misbranding and misleading claims.

The brands include:

• Red Bull Energy Drink
• PepsiCo – Adrenaline Rush Energy Drink
• Reliance Consumer Products – Campa Energy Gold Boost
• Sting Energy Drink
• Hell Energy
• Coca-Cola-backed Monster

Why FSSAI Issued Notices

The FSSAI, in a post on social media platform X, noted that it has not notified any standard for "energy drink" or similar products.

The regulator stated that these brands have "marketed using descriptors such as 'energy drink' on product branding and labelling."

The FSSAI further said that the Food Category System under the FSS Regulations is not intended for product naming or labelling purposes.

"Functional or therapeutic claims, including but not limited to 'vitalizes body and mind', 'enhancing focus', 'boost energy levels', 'aid in general weakness', or similar conditions, are not permissible for food products under the FSS Act 2006 and the Rules and Regulations made thereunder," the regulator said.

Recently, Maharashtra State FDA Minister Narhari Zirwal told the Assembly that the state is set to ban the sale of Sting energy drink within 500 meters of schools.

READ: Hantavirus Outbreak Linked To Luxury Cruise Ship Over, Says WHO

Are Energy Drinks Healthy?

Energy drinks have become a fad among the youth population and are linked to rising fitness awareness. According to the IMARC Group, India's energy drinks market was valued at $1.5 billion in 2025 and is projected to reach $2.9 billion by 2034.

However, Dr. Sudhir Kumar, neurologist at Apollo Hospitals, Hyderabad, said energy drinks may not actually provide "energy."

Rather, they are loaded with "caffeine, sugar and stimulants" that may not be healthy and are "not necessary for exercise, gym workouts or sports."

"Some studies suggest caffeine can improve alertness and endurance in certain athletes. But that doesn't mean everyone who goes to the gym or for a morning run needs an energy drink. Most recreational exercisers do not need energy drinks," said the noted neurologist known popularly as Hyderabad doctor.

He noted that for people working out for less than an hour: "Water is usually enough".

"If you need extra fuel, ordinary carbohydrate-rich foods, such as a banana, fruit, dates or a simple meal, are often safer and cheaper than an energy drink".

Health Risks Of Energy Drinks

READ: Excessive Energy Drinks Damaging Young Adults’ Livers, Experts Warn

Dr Sudhir also noted the downsides of energy drinks many of which contain large amounts of added sugar, high doses of caffeine and multiple stimulants whose combined effects are not always well studied.

He liked excess intake of energy drinks with:

• Weight gain
• Obesity
• Type 2 diabetes (especially sugar-sweetened drinks)
• High blood pressure
• Sleep disturbance
• Anxiety and palpitations
• Dangerous heart rhythm problems."

Over the past few years, there has been a significant increase in young patients presenting with liver dysfunction. Energy drinks may be one of the culprit, according to Dr. Abhideep Chaudhary, President of the Liver Transplantation Society of India (LTSI) and Chairman and Head, Department of HPB and Liver Transplantation, BLK-Max Hospital, New Delhi.

"Three major contributors stand out — energy drinks, alcohol, and high-sugar beverages. Energy drinks, often perceived as harmless, contain high levels of caffeine, sugar, and chemical additives that place immense stress on the liver," the doctor said.

Who Should Avoid Energy Drinks?

Dr. Sudhir suggested people should avoid or strictly limit energy drinks if they are:

• Children and adolescents
• Pregnant or breastfeeding women
• People with heart disease
• People with hypertension
• People with anxiety disorders
• People with sleep problems.

Health officials in the United States are investigating a growing outbreak of Cyclospora, a microscopic parasite that causes the intestinal illness cyclosporiasis.

While the source of the outbreak is not yet clear, cases have been rising in northwest Ohio and southeast Michigan. The Michigan Department of Health and Human Services (MDHHS) reported on July 1 that 170 people across seven counties in Michigan had been infected as of June 30.

"Outbreaks of cyclosporiasis have been occurring across the United States and now here in Michigan. Based on the unusual number of cases we have identified in a little over a week, we anticipate additional cases of illness being reported," said Dr. Natasha Bagdasarian, the state's chief medical executive.

Earlier, the US Centers for Disease Control and Prevention (CDC) reported that 145 people, aged 5 to 86, contracted the parasite between May 1 and June 16. Twenty people were hospitalized, with infections reported across 17 states. New York recorded the highest number of cases.

New York has reported the highest number of cases, with between 31 and 80 infections, according to The Independent. Illinois and Texas have each reported between 11 and 30 cases.

Other affected states include: Alaska, Colorado, Connecticut, Florida, Georgia, Louisiana, Massachusetts, New Jersey, North Carolina, Ohio, Pennsylvania, Tennessee, Virginia, Wisconsin. Each of these states has reported between one and 10 cases.

Also read: Scientific Breakthrough: US Scientists Create First Synthetic Cell That Eats and Reproduces

What Foods Should You Avoid?

According to the CDC, cyclosporiasis outbreaks in the US have frequently been linked to imported fresh produce and to travelers returning from Cyclospora-endemic regions. However, investigators believe the current outbreak is associated with contaminated food consumed within the United States, as most patients had not traveled internationally before becoming ill.

Health officials have not advised people to avoid all fresh produce, as investigators have not yet identified the exact source of the outbreak. However, previous US outbreaks have been linked to imported fresh produce such as:

• Basil
• Cilantro
• Mesclun lettuce
• Raspberries
• Snow peas

So far, no outbreaks have been linked to commercially frozen or canned produce.

The parasite spreads through food or water contaminated with human feces and is not spread directly from person to person.

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How To Prevent Cyclospora Infection

The CDC recommends following safe food handling practices to reduce the risk of infection:

• Wash your hands with soap and water before and after handling fresh fruits and vegetables.
• Wash all fruits and vegetables thoroughly under running water before eating, cutting, or cooking.
• Produce labeled "prewashed" does not need to be washed again.
• Scrub firm produce, such as melons and cucumbers, with a clean produce brush.
• Cut away any bruised or damaged areas before eating.
• Refrigerate cut, peeled, or cooked fruits and vegetables within two hours.

It also advises people traveling to tropical and subtropical regions, where Cyclospora is more common, should also be cautious. Routine chemical disinfectants used on food or water do not reliably kill the parasite.

What Is Cyclospora cayetanensis?

Cyclospora cayetanensis is a microscopic parasite that causes cyclosporiasis, a foodborne intestinal illness. People become infected by consuming contaminated food or water.

The infection commonly causes watery diarrhea and other digestive symptoms. While many cases are mild, the illness can last weeks or even months if left untreated. Doctors typically treat the infection with antibiotics.

People with weakened immune systems, including those with HIV/AIDS, cancer, or other conditions affecting immunity, are at greater risk of developing severe illness.

Symptoms of Cyclospora Infection

Symptoms usually begin about one week after consuming contaminated food or water and may include:

• Watery or explosive diarrhea
• Loss of appetite
• Bloating and gas
• Fatigue
• Low-grade fever
• Nausea
• Stomach cramps
• Vomiting.