A revolutionary study published in BJPsych Open has revealed compelling evidence that a ketogenic diet can have a major impact on mental and physical well-being in bipolar disorder patients. The study, conducted by Dr. Iain Campbell, PhD, Baszucki Metabolic Psychiatry Research Fellow at the University of Edinburgh, investigates how a metabolic-based intervention might represent an exciting new strategy for treating this serious mental illness.

The research is the first in Europe to use neuroimaging methods, namely magnetic resonance spectroscopy (MRS), to investigate changes in brain metabolism in people with bipolar disorder after a ketogenic diet. The imaging findings revealed decreases in excitatory neurotransmitters, which are normally increased in bipolar disorder. This indicates that the ketogenic diet can stabilize brain activity, possibly reducing mood swings and other symptoms of the condition.

The trial involved 27 participants diagnosed with bipolar disorder, 20 of whom successfully completed the 6-8 week program. A staggering 91% of these individuals maintained ketosis, the metabolic state where the body primarily burns fat for energy instead of carbohydrates. Those who provided consistent daily ketone and mental health assessments reported notable improvements in mood, energy levels, anxiety, and impulsivity.

Dr. Campbell, who personally adheres to a ketogenic diet himself in order to treat symptoms of bipolar disorder, discussed the importance of these results:

"We saw indicators of diminished excitotoxicity in the brain regions most implicated in bipolar disorder. These findings are consistent with the metabolic overdrive hypothesis that postulates energy dysregulation within the brain as central to the disorder. Treating the dysregulation by means of a ketogenic diet could be a game-changer in treatment-resistant patients.

Aside from the scientific evidence, personal accounts of study participants underscore the life-altering effect of a ketogenic diet.

"Quite literally, for the first time in years, I felt like my brain was finally fueled correctly," explained a participant.

Another participant called the diet "a lifeline, restoring my energy and sense of hope. I felt like I was finally healing my mind, not just coping with my bipolar symptoms."

One of the very vivid accounts described the impact of ketosis in terms of a relaxing mental atmosphere:

"Applying a ketogenic diet is akin to giving my mind a nice warm bath. The edginess disappears. I am more calm, more clear, and my brain function is restored again."

Aside from the psychological benefits of the study, the ketogenic diet was also seen to have beneficial effects on participants' physical health. Nineteen out of the 20 trial completers lost a total of 9.3 pounds (4.2 kg) on average and showed improvements in body mass index (BMI) and blood pressure.

These results are noteworthy in that numerous treatments for bipolar disorder, such as mood stabilizers and antipsychotic medications, have been linked to metabolic side effects of weight gain and risk of cardiovascular disease. In contributing to the reduction of such risks, a ketogenic diet may provide a double dividend for patients with bipolar disorder.

Link Between Metabolism and Bipolar Disorder

Although the ketogenic diet has previously been known largely for its utility in treating epilepsy that is treatment-resistant, it is a somewhat new area to explore in conditions of psychiatry such as in bipolar disorder. It has come to be known that metabolic imbalance is an underlying factor in causing psychiatric disorders as energy production deficiencies have been recognized to contribute towards neural excitability and mood disruption.

One of the important findings of the study is that people with bipolar disorder tend to have sodium levels higher than usual within their cells. Lithium, a standard mood stabilizer, acts partly by reducing these sodium levels. The ketogenic diet seems to do the same thing, offering a metabolic explanation for its beneficial effect on mood stabilization.

What Is a Ketogenic Diet?

The ketogenic diet is a high-fat, low-carb diet that changes the body's main source of energy from glucose to ketones. As carbohydrate consumption is significantly decreased, the liver breaks down fats into ketones, which can be used as a substitute fuel by the brain and body.

First developed in the 1920s as a therapy for epilepsy, the ketogenic diet has been researched for its therapeutic applications in a variety of neurological and psychiatric disorders, including Alzheimer's disease, Parkinson's disease, and most recently, bipolar disorder.

There's a critical need for bigger replication studies and well-designed randomized clinical trials to follow up on these findings," added Dr. Campbell. "Our findings indicate that a ketogenic diet may be a useful adjunctive treatment for bipolar disorder, bringing new promise to patients who have difficulty with standard therapies.

Ezekiel Jonathan Emanuel, an American oncologist and bioethicist says that this New Year, "Ice cream will make you happy, and that's very important." In an interview with CBS News, Dr Emanuel's unusual advice for 2026, to live longer is by eating ice cream.

How Can Eating Ice Cream Make A Difference, According To Dr Emanuel?

"Ice cream is a good dairy product; it's got protein, its saturated fats are in a globule, so it doesn't affect you as much as saturated fats in meats and other things," he said. "Plus, you typically do it socially with someone else. And you know, being happy is a very important part of living a long time."

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Dr Emanuel says that "we are here for only 75, 85, 90 years". So, he suggests that we must make our lives enjoyable and make it fulfilling. He also wrote a book titled Eat Your Ice Cream: Six Simple Rules For a Long and Healthy Life. "I want people to stop obsessing. make it part of your life. You should like exercising, you should like eating well. Otherwise, you're not going to do it for years and years and decades, which is what's necessary for a long, healthy life," he says.

Read: A Longevity Expert Who Studies 'Super Agers' Eats All THIS In A Day

The book is almost like a handbook of what to do, what to eat, and how to exercise. Most importantly, it talks about the importance of sleep. He emphasizes on stopping the things that are not good for one's health. "'Don't be a schmuck' is my father's reference to us when we were being stupid. And so, there are lots of things that we do as human beings that can be schmucky: smoking, vaping, doing drugs, not taking your vaccines. I don't agree with the current administration, and they're dead wrong on this," he says.

The Safest Level Of Alcohol Consumption Is Zero

Dr Emanuel says that everybody always want to know the safest level or the right amount of alcohol. In his so-called schmuck list, alcohol makes its way. He says, "There has been a lot of research on alcohol, so here's the way I distill it: The safest level is probably zero. There are some studies, and we should be clear, where it's half a cup a day, three cups a week."

However, no one drinks half a glass of wine, to this the doctor says, "So, you drink every other day".

"You're not going from 65% to zero. So, you have to give people reasonable advice. And the reasonable advice is, first of all, no binge drinking, that's really bad for you. Don't drink alone. That's really bad for you. If you're using alcohol as a lubricant for social interaction, which many people do, that's probably good; you're getting some benefit from the social interaction," he explains.

Social Interactions And Relationships Matter

Dr Emanuel's consistent theme is "social interactions", this is something he learned growing up with brother Ari, a super-agent in Hollywood and his other brother Rahm, the former mayor of Chicago and ambassador, who may be running for president of the United States.

"The other thing I think they did, which was super-important for us, is we all slept in the same bedroom. We were a unit. Yes, we fought endlessly. And you know, I like to joke with people, we didn't go to bed until there was blood, you know, because of all the fights. But we were also each other's best friends," he says.

What does it actually take to eat your way into old age with your health intact. According to cardiologist and longevity researcher Eric Topol, it has far less to do with rare genes and far more to do with everyday food choices made consistently over decades.

Topol, author of Super Agers: An Evidence-Based Approach to Longevity, has spent years studying people who live well into their 80s, 90s and even past 100 without developing major chronic illnesses such as heart disease, cancer or neurodegenerative disorders. In an interview with The Washington Post, he explained that his research at the Scripps Research Translational Institute followed more than 1,400 adults aged between 80 and 105 who had avoided these conditions altogether. Genetics, surprisingly, played only a minimal role. Lifestyle, especially diet, did the heavy lifting.

Why genes matter less than daily habits

For Topol, eating for longevity means sticking closely to an anti-inflammatory, Mediterranean-style diet. His plate is built around vegetables, fruits, legumes, nuts, seeds, olive oil and fish, with poultry appearing occasionally. Red meat, however, has been absent from his diet for roughly 45 years. That decision began as a family choice and was reinforced by early evidence linking red meat consumption to cancer risk, particularly relevant given his family history of colon cancer.

The consistency of this approach matters. The Mediterranean diet remains one of the most studied eating patterns in the world, with strong evidence linking it to lower inflammation and reduced risk of chronic disease.

Read: 7 Science-Backed Tips For Healthy Aging, According To Cardiologist

A predictable, protein-rich breakfast

Topol’s days begin early, around 5 am, and breakfast is almost ritualistic. A large bowl of non-fat Greek yogurt forms the base, topped with blueberries, strawberries or both, and finished with a small amount of low-sugar granola. It is simple, repeatable and something he genuinely looks forward to, which he believes matters more than novelty when it comes to sustaining healthy habits.

Nuts for lunch and hydration as a strategy

Lunch is deliberately light. Instead of a full meal, Topol relies on a homemade mix of walnuts, almonds and peanuts. It is filling, nutrient-dense and easy to fit into a busy workday. When lunch becomes social, he gravitates toward salads, occasionally adding crackers or pretzels.

Nuts are his favorite food, even though a history of kidney stones forced him to be mindful of hydration due to their oxalate content. His solution is aggressive fluid intake, especially fizzy water, which allows him to continue eating these foods without triggering problems.

The big salad that anchors dinner

Dinner is the most substantial meal of the day. A large salad made with lettuce and arugula is layered with carrots, tomatoes and avocado. Several times a week, baked salmon or another fish is added on top. The dressing is minimal, just olive oil and balsamic vinegar. Sometimes he adds crumbled blue cheese, Gorgonzola or seasonal corn for variety.

The meal is quick to prepare, deeply satisfying and so central to his routine that skipping it leaves him feeling noticeably off.

Calories, fasting and mindful indulgences

Topol generally eats around 1,500 to 1,600 calories a day and avoids eating late at night, aiming for a roughly 12-hour overnight fast. If hunger strikes early in the evening, he keeps it simple with dried fruit, a few nuts or an occasional low-calorie cookie.

There are foods he avoids keeping at home altogether. Tortilla chips test his willpower, and most commercial ice creams are too heavily processed for his comfort.

What he tells patients about eating better

In his clinic, Topol begins diet conversations by asking patients exactly what they eat across the day. Many are unaware of how much sugar, alcohol or excess protein they consume, often assuming these habits are normal. His advice is steady and evidence-based. Eat mostly whole foods, prioritize plants and fish, hydrate well, limit ultra-processed products and pay attention not just to what you eat, but when you eat it.

It is widely accepted that what we eat shapes how we age, but new research suggests sugar may be one of the strongest drivers of faster ageing at the cellular level.

Using an advanced method known as the “epigenetic clock,” researchers uncovered a clear link between added sugar intake and the speed at which cells begin to show signs of ageing. The findings point to sugar as a key factor in biological ageing, even among people who otherwise eat well.

What Is The Epigenetic Clock?

The “epigenetic clock” is not a futuristic idea. It is a scientific tool that examines chemical changes in DNA to estimate biological age, which reflects the condition of cells rather than the number of years a person has lived.

For this study, scientists followed 342 women in midlife. They analysed dietary patterns and measured biological age using DNA samples collected from saliva, allowing them to compare what participants ate with how quickly their cells appeared to age.

Can Sugar Speed Up Cellular Aging?

The results showed a consistent pattern. Every gram of added sugar consumed was linked to a measurable increase in biological ageing. This effect appeared even in participants who followed generally healthy diets, suggesting sugar has an independent impact on cellular health. In contrast, diets lower in added sugar and richer in nutrients were associated with slower ageing at the cellular level.

Sugar And Longevity

Researchers observed that participants who consumed fewer added sugars tended to have a younger biological age. The strongest protective effects were seen in those whose diets focused on whole foods, fibre, and essential vitamins and minerals. These findings suggest that small dietary changes could influence long-term health and longevity.

Cutting Back On This One Food Could Help You Live Longer

• Cut the sugar, turn back time: Reducing added sugar intake by just 10 grams a day, roughly the amount found in a typical granola bar, was linked to a potential reversal of biological ageing by up to 2.4 months.
• Nutrient-rich diets for the win: Diets high in vitamins A, C, and E, along with magnesium and fibre, were strongly associated with a younger biological age.
• Mediterranean magic: Mediterranean-style diets, known for their anti-inflammatory and antioxidant properties, showed the strongest link to slower cellular ageing.

Excess Sugar Harms Cellular Health

High sugar intake contributes to chronic inflammation, oxidative stress, and damage to DNA, all of which place strain on the body’s cells. While the occasional sweet treat is unlikely to cause harm, regularly consuming large amounts of sugar can gradually interfere with the body’s natural repair systems.

Over time, this damage may accelerate ageing and increase the risk of chronic disease.

Simple Sugar Swaps To Try

Cutting back on added sugar does not mean giving up flavour. Simple changes can make a difference:

• Instead of candy: Choose dark chocolate with at least 70 per cent cacao, which offers antioxidants alongside sweetness.
• For a sweet breakfast: Opt for oatmeal topped with fresh berries or a protein-rich smoothie rather than highly sweetened cereals.
• Happy drinking: Replace sugary soft drinks or energy drinks with sparkling water or lower-sugar soda alternatives.

This research reinforces the idea that everyday food choices have a direct impact on cellular health. By prioritising whole foods and reducing added sugars, people may not only support better overall health but also slow the biological ageing process itself.

Small, consistent changes to diet could help protect cells over time and support a longer, healthier life.