A revolutionary study published in BJPsych Open has revealed compelling evidence that a ketogenic diet can have a major impact on mental and physical well-being in bipolar disorder patients. The study, conducted by Dr. Iain Campbell, PhD, Baszucki Metabolic Psychiatry Research Fellow at the University of Edinburgh, investigates how a metabolic-based intervention might represent an exciting new strategy for treating this serious mental illness.

The research is the first in Europe to use neuroimaging methods, namely magnetic resonance spectroscopy (MRS), to investigate changes in brain metabolism in people with bipolar disorder after a ketogenic diet. The imaging findings revealed decreases in excitatory neurotransmitters, which are normally increased in bipolar disorder. This indicates that the ketogenic diet can stabilize brain activity, possibly reducing mood swings and other symptoms of the condition.

The trial involved 27 participants diagnosed with bipolar disorder, 20 of whom successfully completed the 6-8 week program. A staggering 91% of these individuals maintained ketosis, the metabolic state where the body primarily burns fat for energy instead of carbohydrates. Those who provided consistent daily ketone and mental health assessments reported notable improvements in mood, energy levels, anxiety, and impulsivity.

Dr. Campbell, who personally adheres to a ketogenic diet himself in order to treat symptoms of bipolar disorder, discussed the importance of these results:

"We saw indicators of diminished excitotoxicity in the brain regions most implicated in bipolar disorder. These findings are consistent with the metabolic overdrive hypothesis that postulates energy dysregulation within the brain as central to the disorder. Treating the dysregulation by means of a ketogenic diet could be a game-changer in treatment-resistant patients.

Aside from the scientific evidence, personal accounts of study participants underscore the life-altering effect of a ketogenic diet.

"Quite literally, for the first time in years, I felt like my brain was finally fueled correctly," explained a participant.

Another participant called the diet "a lifeline, restoring my energy and sense of hope. I felt like I was finally healing my mind, not just coping with my bipolar symptoms."

One of the very vivid accounts described the impact of ketosis in terms of a relaxing mental atmosphere:

"Applying a ketogenic diet is akin to giving my mind a nice warm bath. The edginess disappears. I am more calm, more clear, and my brain function is restored again."

Aside from the psychological benefits of the study, the ketogenic diet was also seen to have beneficial effects on participants' physical health. Nineteen out of the 20 trial completers lost a total of 9.3 pounds (4.2 kg) on average and showed improvements in body mass index (BMI) and blood pressure.

These results are noteworthy in that numerous treatments for bipolar disorder, such as mood stabilizers and antipsychotic medications, have been linked to metabolic side effects of weight gain and risk of cardiovascular disease. In contributing to the reduction of such risks, a ketogenic diet may provide a double dividend for patients with bipolar disorder.

Link Between Metabolism and Bipolar Disorder

Although the ketogenic diet has previously been known largely for its utility in treating epilepsy that is treatment-resistant, it is a somewhat new area to explore in conditions of psychiatry such as in bipolar disorder. It has come to be known that metabolic imbalance is an underlying factor in causing psychiatric disorders as energy production deficiencies have been recognized to contribute towards neural excitability and mood disruption.

One of the important findings of the study is that people with bipolar disorder tend to have sodium levels higher than usual within their cells. Lithium, a standard mood stabilizer, acts partly by reducing these sodium levels. The ketogenic diet seems to do the same thing, offering a metabolic explanation for its beneficial effect on mood stabilization.

What Is a Ketogenic Diet?

The ketogenic diet is a high-fat, low-carb diet that changes the body's main source of energy from glucose to ketones. As carbohydrate consumption is significantly decreased, the liver breaks down fats into ketones, which can be used as a substitute fuel by the brain and body.

First developed in the 1920s as a therapy for epilepsy, the ketogenic diet has been researched for its therapeutic applications in a variety of neurological and psychiatric disorders, including Alzheimer's disease, Parkinson's disease, and most recently, bipolar disorder.

There's a critical need for bigger replication studies and well-designed randomized clinical trials to follow up on these findings," added Dr. Campbell. "Our findings indicate that a ketogenic diet may be a useful adjunctive treatment for bipolar disorder, bringing new promise to patients who have difficulty with standard therapies.

What you eat does far more than simply fuel your day. Over time, the quality of food, the way it is prepared, and how often it appears on your plate can significantly influence long-term health. Increasingly, research shows that certain types of foods may quietly contribute to inflammation, metabolic dysfunction, and chronic illnesses such as heart disease, diabetes, and cancer.

Researchers at the VCU Massey Comprehensive Cancer Center have been exploring how diet and environmental factors shape health outcomes. Scientists there are particularly studying compounds called advanced glycation end products (AGEs) and their connection to chronic diseases.

Why Ultra-Processed Foods Are A Concern

Recent dietary recommendations from the United States Department of Health and Human Services emphasize a simple principle: eat real food and cut back on ultra-processed products.

Ultra-processed foods include packaged snacks, highly refined products, and foods loaded with added sugars. These foods are designed for convenience and long shelf life, but research increasingly links them to poor health outcomes.

Experts studying nutrition note that most research examining ultra-processed foods consistently shows they are harmful when consumed frequently. One major reason is their association with higher levels of harmful compounds such as AGEs.

Today, avoiding them entirely is difficult. Studies suggest that more than 70% of foods available in grocery stores are processed or ultra-processed in some way, making healthy choices more challenging for many people.

What Are AGEs And Why Do They Matter?

Advanced glycation end products, or AGEs, are harmful compounds that form when proteins or fats combine with sugars in the bloodstream. While small amounts occur naturally in foods, they tend to be much higher in ultra-processed items.

Once consumed, these compounds can accumulate in tissues throughout the body. Over time, this buildup may accelerate tissue aging and trigger harmful biological processes.

Research shows that AGEs can contribute to inflammation, oxidative stress, and metabolic dysfunction—three mechanisms strongly linked with chronic diseases. Patients with long-term conditions such as diabetes, cardiovascular disease, and certain cancers often show significantly higher levels of these compounds.

Because AGEs accumulate slowly over a lifetime, they may also reflect long-term lifestyle and environmental exposures.

Cooking Methods Can Also Increase Risk

It is not just what you eat that matters—but also how you cook it.

High-temperature, dry cooking methods such as grilling, roasting, or frying can significantly increase AGE formation in food. Many people assume grilling is automatically healthier than deep-frying, but when it comes to AGE formation, intense heat can still promote the production of these compounds.

This does not mean you must avoid these cooking methods entirely, but balancing them with gentler methods like steaming, boiling, or stewing may help reduce exposure.

Foods To Limit For Better Health

To reduce long-term health risks, experts recommend limiting:

• Ultra-processed foods, including packaged snacks and ready-to-eat meals
• Highly refined foods made from processed grains
• Products with high added sugar content
• Foods cooked at very high temperatures frequently

These foods often contain higher levels of AGEs and other compounds that may stress the body over time.

The Power Of Moderation

Dietary changes do not require giving up favorite foods completely. Experts often emphasise moderation rather than strict restriction.

Balancing high-AGE foods with healthier, minimally processed options can help the body manage these compounds more effectively. Whole foods, balanced meals, and mindful preparation methods can make a meaningful difference over time.

Ultimately, the goal is simple: prioritize real, less-processed foods whenever possible and keep indulgences occasional. Small, consistent changes in everyday eating habits can go a long way in lowering the risk of chronic diseases and supporting long-term health.

Danica McKellar, American actress said she was embarrassed to admit that she liked tasting her placenta. While she did not go into childbirth thinking she was going to taste her placenta, she says she is glad she did so.

She said this while explaining her surprising postpartum culinary experience in a conversation with Bobby Bones on The BobbyCast.

"My doula said, do you want to taste the placenta? I'd just given birth. And I'm like, sure. I mean, you're not even, you're not in your right mind. She gave me a piece of it. Bobby, it was like the best filet mignon that I have ever tasted. But more," she said.

She continued that she was embarrassed about how much she loved it. "It was bizarre. I thought, what is this, some sort of weird satanic...Am I a cannibal?"

She is now mom to 15-year-old son Draco Verta, who she shares with her ex-husband and composer Mike Verta.

Why Do People Eat Placenta?

A 2014 BBC report notes that placenta sustains life in the womb and leaves the mother once it has served its purposes after the childbirth. The nutrients that have passed from mother to fetus over the months of pregnancy are still packed inside the placenta and should not be wasted. Instead, the raw placenta, many believe, could provide what the mother needs to recover from childbirth and begins breastfeeding.

Some women, as the BBC report notes, are also choosing to drink the placenta in a fruit smoothie within hours of giving birth. While others keep it cool and send it off to be dried and made into capsules, or ripping chunk of it and placing it by their gums.

As per Mayo Clinic, some people believe that eating placenta can help them recover from postpartum depression. However, the US Centers for Disease Control and Prevention issued a warning against taking placenta capsules. The warning was based on the case in which newborn developed an infection called group B streptococcus after the mother took placenta capsules.

The mother was thought to be infected with group B strep bacteria that came from the placenta because the capsules tested positive for the bacteria. Then the infection spread to the infant. Group B strep can cause serious illness in newborns. That may include a severe infection called sepsis. Group B strep also can lead to meningitis. Meningitis is an infection that affects the lining of the brain and spinal cord.

This infection happens when one processes their placenta and it could expose the placenta to bacteria or viruses.

Placenta And What It Holds

The placenta contain several hormones, including oxytocin, estrogen, progesterone, and relaxin. It is also rich in protein, amino acids, and minerals. However, the claims of people saying that it is healthy and should be consumed after delivering a child to avoid postpartum depression have not been fully tested. There are however cases where animals other than humans eat placenta after birth as it could reduce there labor pain. However, the same has not been proven in humans.

Early childhood is a crucial stage for emotional and behavioural development and can shape long-term mental and physical well-being.

During this period, children may display internalising symptoms such as anxiety and withdrawal, or externalising behaviours like aggression and hyperactivity—patterns that can indicate a higher risk of later mental health problems.

And a new JAMA study suggests that diets high in ultra-processed foods (UPFs) in early childhood may be linked to later behavioral challenges.

Over the span of seven years, Canadian researchers analyzed 2.077 children using a food frequency questionnaire (FFQ) comprising 112 items to assess dietary intake at three years of age, categorizing foods according to the NOVA classification system.

Then, they evaluated behavioral and emotional outcomes at five years using the Child Behavior Checklist (CBCL) T-score scales based on caregiver responses, which represent standardized behavioral and emotional symptom scores rather than clinical diagnoses.

The study discovered that higher UPF intake at the age of three was associated with adverse behavioral and emotional symptoms at the age of five.

Notably, the scientists found that at the age of three, UPFs made up about 45.5 percent of children’s daily energy intake on average. By age five, average behaviour scores were 44.6 for internalising problems, 39.6 for externalising problems, and 41.2 overall.

Additionally, they noted that every 10 percent increase in energy from UPFs was linked to slightly higher behaviour problem scores across all categories. In contrast, replacing 10 percent of energy gained from UPFs with minimally processed foods (MPF) was linked to lower internalising, externalising and overall behaviour problem scores.

Although the effects were modest, the findings highlight that early dietary patterns may influence child development, reinforcing the importance of policies promoting healthier, minimally processed diets.

What Are UPFs?

Unlike minimally processed foods such as fruits or vegetables, UPFs are typically designed for longer shelf life, convenience and enhanced taste appeal.

Several studies have linked high UPF consumption to obesity, metabolic disorders and cardiovascular disease. One recent study even suggested that eliminating UPFs could significantly accelerate weight loss, while others have connected them to a higher risk of chronic illness.

How To Recognize Ultra-Processed Foods?

In spite of all this danger, UPFs own the shelves in supermarkets, camouflaged as health foods. Some telltale signs include:

Emulsifiers: Employed to mix ingredients together and produce creamy textures. Research indicates they can interfere with gut microbiota and the intestinal mucus barrier.

• Artificial sweeteners: Contained in low-calorie beverages and foods, these substances can quietly affect appetite and gut microbiota.
• Modified starches: Digested speedily and containing low amounts of fiber, they cause peaks in blood glucose with minimal nutrition.
• Protein isolates: Typical of shakes and meat alternatives, these isolate protein from its native environment and indicate intensive processing.
• Stabilizers and gums: Added to enhance texture, these are unknown in home kitchens and lead to gastrointestinal distress.

How to Make Smarter Swaps To Make At The Grocery Store

Cutting UPF intake doesn't need a drastic lifestyle adjustment. Minimally processed, simple alternatives can offer the same convenience without toxic additives:

• Packed legumes and fish: Canned beans, chickpeas, lentils, and plain fish are healthy and shelf-stable.
• Frozen vegetables and fruits: Often as nutrient-dense as their fresh counterparts.
• Whole grains: Opt for plain brown rice or quinoa pouches in lieu of flavored instant packets.
• Additive-free sauces: Passata, tahini, pesto, and coconut milk present wholesome, ready-to-use meal bases.

Although UPFs are not going away from world diets anytime in the near future, knowledge and wise food choices can help counteract them. Making whole and minimally processed foods a priority is not merely a plan for improved health; it is a protection for ongoing reproductive and metabolic health.