A revolutionary study published in BJPsych Open has revealed compelling evidence that a ketogenic diet can have a major impact on mental and physical well-being in bipolar disorder patients. The study, conducted by Dr. Iain Campbell, PhD, Baszucki Metabolic Psychiatry Research Fellow at the University of Edinburgh, investigates how a metabolic-based intervention might represent an exciting new strategy for treating this serious mental illness.

The research is the first in Europe to use neuroimaging methods, namely magnetic resonance spectroscopy (MRS), to investigate changes in brain metabolism in people with bipolar disorder after a ketogenic diet. The imaging findings revealed decreases in excitatory neurotransmitters, which are normally increased in bipolar disorder. This indicates that the ketogenic diet can stabilize brain activity, possibly reducing mood swings and other symptoms of the condition.

The trial involved 27 participants diagnosed with bipolar disorder, 20 of whom successfully completed the 6-8 week program. A staggering 91% of these individuals maintained ketosis, the metabolic state where the body primarily burns fat for energy instead of carbohydrates. Those who provided consistent daily ketone and mental health assessments reported notable improvements in mood, energy levels, anxiety, and impulsivity.

Dr. Campbell, who personally adheres to a ketogenic diet himself in order to treat symptoms of bipolar disorder, discussed the importance of these results:

"We saw indicators of diminished excitotoxicity in the brain regions most implicated in bipolar disorder. These findings are consistent with the metabolic overdrive hypothesis that postulates energy dysregulation within the brain as central to the disorder. Treating the dysregulation by means of a ketogenic diet could be a game-changer in treatment-resistant patients.

Aside from the scientific evidence, personal accounts of study participants underscore the life-altering effect of a ketogenic diet.

"Quite literally, for the first time in years, I felt like my brain was finally fueled correctly," explained a participant.

Another participant called the diet "a lifeline, restoring my energy and sense of hope. I felt like I was finally healing my mind, not just coping with my bipolar symptoms."

One of the very vivid accounts described the impact of ketosis in terms of a relaxing mental atmosphere:

"Applying a ketogenic diet is akin to giving my mind a nice warm bath. The edginess disappears. I am more calm, more clear, and my brain function is restored again."

Aside from the psychological benefits of the study, the ketogenic diet was also seen to have beneficial effects on participants' physical health. Nineteen out of the 20 trial completers lost a total of 9.3 pounds (4.2 kg) on average and showed improvements in body mass index (BMI) and blood pressure.

These results are noteworthy in that numerous treatments for bipolar disorder, such as mood stabilizers and antipsychotic medications, have been linked to metabolic side effects of weight gain and risk of cardiovascular disease. In contributing to the reduction of such risks, a ketogenic diet may provide a double dividend for patients with bipolar disorder.

Link Between Metabolism and Bipolar Disorder

Although the ketogenic diet has previously been known largely for its utility in treating epilepsy that is treatment-resistant, it is a somewhat new area to explore in conditions of psychiatry such as in bipolar disorder. It has come to be known that metabolic imbalance is an underlying factor in causing psychiatric disorders as energy production deficiencies have been recognized to contribute towards neural excitability and mood disruption.

One of the important findings of the study is that people with bipolar disorder tend to have sodium levels higher than usual within their cells. Lithium, a standard mood stabilizer, acts partly by reducing these sodium levels. The ketogenic diet seems to do the same thing, offering a metabolic explanation for its beneficial effect on mood stabilization.

What Is a Ketogenic Diet?

The ketogenic diet is a high-fat, low-carb diet that changes the body's main source of energy from glucose to ketones. As carbohydrate consumption is significantly decreased, the liver breaks down fats into ketones, which can be used as a substitute fuel by the brain and body.

First developed in the 1920s as a therapy for epilepsy, the ketogenic diet has been researched for its therapeutic applications in a variety of neurological and psychiatric disorders, including Alzheimer's disease, Parkinson's disease, and most recently, bipolar disorder.

There's a critical need for bigger replication studies and well-designed randomized clinical trials to follow up on these findings," added Dr. Campbell. "Our findings indicate that a ketogenic diet may be a useful adjunctive treatment for bipolar disorder, bringing new promise to patients who have difficulty with standard therapies.

High-protein diets have become increasingly popular among fitness enthusiasts and health-conscious masses.

However, a new scientific review suggests that many adults, particularly those who are sedentary, maybe consuming more protein than they actually need.

The study also shows that eating less protein rather than more may support healthier ageing by improving metabolism and reducing age-related biological changes.

Are Low Protein Diets The Key To Live Longer?

The review, published by Cell Press, studied data from more than 350 studies investigating how dietary protein affects ageing and metabolic health.

Researchers concluded that reducing overall protein intake, or restricting certain amino acids like methionine, isoleucine, and valine, activates biological pathways linked to better metabolic function, cellular maintenance, and lower inflammation.

According to the researchers, several of these benefits appear to be driven by fibroblast growth factor 21 (FGF21), a hormone that rises when protein intake falls.

Higher FGF21 levels have been associated with better insulin sensitivity, better blood sugar regulation, increased energy expenditure, and healthier ageing in experimental models.

Lead author Dr Dudley Lamming, professor at the University of Wisconsin-Madison, said the growing popularity of protein-enriched foods may not benefit everyone.

"Our review suggests that reducing protein intake, rather than calories, may provide many of the same metabolic benefits while being easier for people to follow," the research team noted, adding that protein recommendations may need to be tailored according to an individual's age and physical activity rather than using a one-size-fits-all approach.

Also read: Do Most Adults Eat More Protein Than They Need? New Review Challenges The 'High-Protein' Trend

Excessively High-Protein Diets May Increase Metabolic Burden

HealthandMe spoke to Dr. Mukesh Thakur, Director - Internal Medicine, Acute Medicine & Clinical Transformation, Sir H. N. Reliance Foundation Hospital, to find out who should and should not cut back on protein to improve longevity.

The doctor says that protein is essential for maintaining muscle mass, supporting immune function, and promoting overall health.

Dr Thakur says, "The optimal amount of protein varies depending on factors such as age, overall health status, and, most importantly, an individual's level of physical activity. For people who are largely sedentary, consuming very high amounts of protein may not offer additional health benefits."

He added that if the excess protein consumed is not utilized to build or maintain muscle through regular physical activity, it may contribute to excess calorie intake and increase metabolic stress.

He also explains, "Emerging research also suggests that chronically high protein intake, particularly from animal sources, may overstimulate biological pathways such as IGF-1 and mTOR, which have been linked to accelerated ageing in experimental studies."

To sum up, for individuals with obesity or diabetes, excessively high-protein diets can be particularly concerning, as they may increase the metabolic burden and are not necessarily associated with better health outcomes.

Conclusion

The researchers caution that the findings should not be interpreted as a recommendation for everyone to reduce protein intake.

While sedentary adults consuming excessive protein may benefit from moderation, adequate protein remains essential for older adults, athletes, pregnant women, children, and people recovering from illness or surgery to maintain muscle mass and overall health.

Today, protein has found its way into everything from coffee and cereal to chips and even water. But a new scientific review suggests that for many adults, especially those who are not physically active, consuming more protein than needed may offer little benefit and could even have pose unintended health consequences.

Published in Cell Press Blue, the review analyzed more than 350 studies on restriction of protein, aging, metabolism, and longevity across humans and animal models.

Researchers concluded that while protein remains essential in one's diet, most sedentary adults are likely consuming more than they need. It also found that bringing down excess protein intake may support healthier aging.

“It’s absolutely crystal clear that there are benefits of protein to muscle growth and exercise response of active individuals,” said Dr. Dudley Lamming, aging researcher at the University of Wisconsin-Madison and the review’s corresponding author.

“But because most people are relatively sedentary, many people are likely consuming more protein than they actually need, which probably has negative health consequences,” he added.

Can Eating Less Protein Help?

The researchers explain that eating less protein appears to activate several biological pathways that are associated to healthy aging.

One key player is fibroblast growth factor 21 (FGF21), a hormone that rises when protein intake is reduced.

Higher FGF21 levels have been associated with increased energy expenditure, better blood sugar control, lower inflammation, and healthier metabolism. Animal studies have also linked elevated FGF21 to longer lifespan.

The review also highlights specific amino acids, including methionine, isoleucine, and valine, which may influence aging-related processes when consumed in excess. Restricting these amino acids appears to alleviate cellular stress and improve metabolic health in experimental studies.

Also read: No Junk Food Near Schools! Maharashtra FDA Bans Sale Of Foods & Drinks High In Fat, Salt & Sugar

Researchers caution that the findings do not mean everyone should start eating a low-protein diet.

Protein requirements vary depending on age, activity level, health status, and life stage. Athletes, pregnant women, people recovering from illness or surgery, and many older adults often require more protein for muscle maintenance and recovery.

“Recent recommendations have encouraged people to eat more protein, but they’ve also encouraged people to exercise more,” Lamming said. “We probably need to personalize protein recommendations based not just on age, but also on how physically active people are.”

How Much Protein Do Adults Actually Need?

For healthy adults, the recommended dietary allowance is 0.8 grams of protein per kilogram of body weight daily. Although individual needs increase with regular exercise, aging, pregnancy, or certain medical conditions.

Many adults already exceed these recommendations through regular meals alone, even before adding protein supplements.

The researchers acknowledge that much of the evidence comes from animal studies, and long-term human trials are still limited. They say future research should determine exactly who benefits from lower protein intake and who needs more.

As protein-fortified products continue to flood supermarket shelves, the researchers argue that dietary advice should become more personalized rather than assuming higher protein intake benefits everyone.

Ultra-processed foods (UPFs), typically high in salt, sugar, and unhealthy fats, have long been associated with obesity, diabetes, hypertension, and other chronic diseases.

Now, new research suggests that the vast majority of foods marketed for toddlers in the US fall into this category. A study led by the University of Texas at Austin found that more than 80% of toddler foods sold in US grocery stores are ultra-processed, while nearly half fail to meet at least one nutrient standard set by the World Health Organization (WHO) for commercial foods intended for children aged 6 to 36 months.

Majority Of Toddler Foods Are Ultra-Processed

Also read: Can Your Child’s Diet Shape Future Diabetes Risk? Study Links Ultra-Processed Foods To Early Insulin Responses

Researchers analyzed 2,783 toddler food products sold across 21 grocery stores in Texas. Using the Nova classification system, they found that 81% of products were ultra-processed, while 49% failed to meet at least one WHO nutrient standard.

Among the products analyzed:

• 81% were classified as ultra-processed.
• 17% exceeded WHO recommendations for sugar.
• 25% exceeded recommended sodium levels.
• 11% exceeded recommended fat levels.
• 12% exceeded recommended energy density.

Products that exceeded WHO recommendations included:

• Fruit pouches (high in sugar)
• Oat bars (high in sugar and calories)
• Mac and cheese (high in sodium and fat)
• Turkey sticks (high in sodium and fat)
• Cheese puffs (high in calories)
• Peanut butter puffs (high in sodium, fat, and calories)

“Many parents may assume that products sold on the baby/toddler food aisles of their grocery stores have to meet certain nutrient standards. Our findings highlight that half of the toddler foods available in local grocery stores do not,” said Erin A. Hudson, a University of Texas at Austin graduate student and science policy fellow with the American Society for Nutrition.

Hudson urged parents "to be vigilant in checking labels and ingredients to determine the nutrient content and processing level of products for their toddlers".

Read More: 'Let's Fix Our Food': India Launches New Policy To Fight Childhood Obesity, Boost Nutrition

Why Is This Concerning?

The toddler years are a crucial period for developing lifelong eating habits and taste preferences. Diets high in added sugars and ultra-processed foods during early childhood may increase the risk of obesity, diabetes, cardiovascular disease, and other chronic illnesses later in life.

The researchers found that ultra-processed toddler foods were significantly more likely to be high in sugar than less-processed alternatives. Excess sugar intake in young children has been consistently linked to poor health outcomes, including obesity and metabolic disorders.

The findings come as the US Food and Drug Administration (FDA) is considering new guidelines for front-of-package nutrition labels, healthy claims and marketing of food products to children. The US currently does not require warning labels on any food products that are high in sugar, sodium or calories.

What Are Ultra-Processed Foods?

Ultra-processed foods (UPFs) are industrially manufactured products made with ingredients and additives rarely used in home cooking, including preservatives, emulsifiers, artificial sweeteners, colorants, flavor enhancers, and hydrogenated oils. They are generally high in refined carbohydrates, added sugars, unhealthy fats, and sodium, while being low in fiber and other essential nutrients.

Research suggests that diets high in UPFs may promote chronic inflammation, disrupt the gut microbiome, and impair insulin regulation over time, potentially increasing the risk of obesity, type 2 diabetes, cardiovascular disease, and other chronic illnesses from an early age.