A revolutionary study published in BJPsych Open has revealed compelling evidence that a ketogenic diet can have a major impact on mental and physical well-being in bipolar disorder patients. The study, conducted by Dr. Iain Campbell, PhD, Baszucki Metabolic Psychiatry Research Fellow at the University of Edinburgh, investigates how a metabolic-based intervention might represent an exciting new strategy for treating this serious mental illness.
The research is the first in Europe to use neuroimaging methods, namely magnetic resonance spectroscopy (MRS), to investigate changes in brain metabolism in people with bipolar disorder after a ketogenic diet. The imaging findings revealed decreases in excitatory neurotransmitters, which are normally increased in bipolar disorder. This indicates that the ketogenic diet can stabilize brain activity, possibly reducing mood swings and other symptoms of the condition.
The trial involved 27 participants diagnosed with bipolar disorder, 20 of whom successfully completed the 6-8 week program. A staggering 91% of these individuals maintained ketosis, the metabolic state where the body primarily burns fat for energy instead of carbohydrates. Those who provided consistent daily ketone and mental health assessments reported notable improvements in mood, energy levels, anxiety, and impulsivity.
Dr. Campbell, who personally adheres to a ketogenic diet himself in order to treat symptoms of bipolar disorder, discussed the importance of these results:
"We saw indicators of diminished excitotoxicity in the brain regions most implicated in bipolar disorder. These findings are consistent with the metabolic overdrive hypothesis that postulates energy dysregulation within the brain as central to the disorder. Treating the dysregulation by means of a ketogenic diet could be a game-changer in treatment-resistant patients.
Aside from the scientific evidence, personal accounts of study participants underscore the life-altering effect of a ketogenic diet.
"Quite literally, for the first time in years, I felt like my brain was finally fueled correctly," explained a participant.
Another participant called the diet "a lifeline, restoring my energy and sense of hope. I felt like I was finally healing my mind, not just coping with my bipolar symptoms."
One of the very vivid accounts described the impact of ketosis in terms of a relaxing mental atmosphere:
"Applying a ketogenic diet is akin to giving my mind a nice warm bath. The edginess disappears. I am more calm, more clear, and my brain function is restored again."
Aside from the psychological benefits of the study, the ketogenic diet was also seen to have beneficial effects on participants' physical health. Nineteen out of the 20 trial completers lost a total of 9.3 pounds (4.2 kg) on average and showed improvements in body mass index (BMI) and blood pressure.
These results are noteworthy in that numerous treatments for bipolar disorder, such as mood stabilizers and antipsychotic medications, have been linked to metabolic side effects of weight gain and risk of cardiovascular disease. In contributing to the reduction of such risks, a ketogenic diet may provide a double dividend for patients with bipolar disorder.
Although the ketogenic diet has previously been known largely for its utility in treating epilepsy that is treatment-resistant, it is a somewhat new area to explore in conditions of psychiatry such as in bipolar disorder. It has come to be known that metabolic imbalance is an underlying factor in causing psychiatric disorders as energy production deficiencies have been recognized to contribute towards neural excitability and mood disruption.
One of the important findings of the study is that people with bipolar disorder tend to have sodium levels higher than usual within their cells. Lithium, a standard mood stabilizer, acts partly by reducing these sodium levels. The ketogenic diet seems to do the same thing, offering a metabolic explanation for its beneficial effect on mood stabilization.
The ketogenic diet is a high-fat, low-carb diet that changes the body's main source of energy from glucose to ketones. As carbohydrate consumption is significantly decreased, the liver breaks down fats into ketones, which can be used as a substitute fuel by the brain and body.
First developed in the 1920s as a therapy for epilepsy, the ketogenic diet has been researched for its therapeutic applications in a variety of neurological and psychiatric disorders, including Alzheimer's disease, Parkinson's disease, and most recently, bipolar disorder.
There's a critical need for bigger replication studies and well-designed randomized clinical trials to follow up on these findings," added Dr. Campbell. "Our findings indicate that a ketogenic diet may be a useful adjunctive treatment for bipolar disorder, bringing new promise to patients who have difficulty with standard therapies.
Credit: Canva
The World Health Organization is asking countries across the world to increase taxes on sugary drinks and alcohol to reduce cases of chronic conditions such as Type 2 diabetes, obesity, heart disease and fatty liver.
In a January 13 virtual conference, WHO Director-General Dr Tedros Adhanom Ghebreyesus said: "Health taxes have been shown to reduce consumption of these harmful products, helping to prevent disease and reduce the burden on health systems.
"At the same time, they generate an income stream that governments can use to invest in health, education and social protection."
According to a recent report on sugar-sweetened beverages taxes, at least 116 countries tax sugary drinks, including sodas or carbonated canned drinks, but other high-sugar products, such as 100 per cent fruit juices, sweetened milk drinks and ready-to-drink coffees and teas, escape taxation.
Additionally, another report on alcohol taxes shows that even though 167 countries levy taxes on liquor, wine and beer, alcohol has become more affordable or remained unchanged in price in most countries since 2022, as taxes do not get adjusted for inflation and income growth.
Apart from increasing the risk for diabetes and heart disease, sugary drinks can also worsen the risk for dental problems, gout, non-alcoholic fatty liver disease and potential kidney/bone issues.
Due to being cheap for consumption, the harmful products are generating billions of dollars in profit for countries and corporations, alike.
However, health systems across the globe are facing mounting financial pressure from preventable noncommunicable diseases and injuries and an increase an taxes will help curb these costs , the WHO said.
Moreover, high tax rates will discourage consumers from buying such drinks and causing long-term damage to their body.
Yes, the WHO noted that when the UK implemented a tax on sugary drinks in 2018, the country saw a overall reduced sugar consumption, £338 million revenue increase in 2024 and a lower obesity rates in girls aged 10 and 11, especially in deprived communities.
“These are very important findings for preservatives that are not only widely used in the French and European markets, but also in the United States,” said senior author Mathilde Touvier, principal investigator of the NutriNet-Santé study used for the research, as per CTV News.
The cancer-focused study, published in The BMJ, examined the effects of 58 preservatives among nearly 105,000 people who were cancer-free in 2009 and followed for up to 14 years.
Sodium nitrite, commonly used in processed meats such as bacon, ham, and deli meats, was linked to a 32 percent higher risk of prostate cancer. Potassium nitrate was associated with a 22 percent increased risk of breast cancer and a 13 percent rise in overall cancer risk, results showed.
Credits: Wikimedia Commons, X, Facebook
US President Donald Trump’s eating habits have drawn a blunt and unusually candid assessment from Health Secretary Robert F Kennedy Jr, who described them as “unhinged” and dominated by fast food, candy, and Diet Coke.
Speaking on a podcast, Kennedy said Trump regularly consumes what he called “really bad food,” with McDonald’s, sweets, and Diet Coke forming a constant part of his routine. “The interesting thing about the president is that he eats really bad food, which is McDonald's. And then candy and Diet Coke,” Kennedy said, adding that Trump drinks Diet Coke “at all times.”
Kennedy, who has travelled with Trump, painted a vivid picture of the president’s food habits on the road. “If you travel with him, you get this idea that he's just pumping himself full of poison all day long,” he said.
Despite the criticism, Kennedy also expressed disbelief at Trump’s physical resilience. “He’s got the constitution of a deity,” he remarked. “I don’t know how he’s alive, but he is.”
According to Kennedy, Trump has his own reasoning for relying on food from large corporate chains while travelling. The president, he said, believes such food is safer and more predictable.
“[Trump] says that the only time that he eats junk food is when he's on the road, and he wants to eat food from big corporations because he trusts it,” Kennedy explained. Trump reportedly worries about falling ill while travelling and prefers food he considers consistent and hygienic.
Kennedy added that Trump’s energy levels remain astonishing despite his diet. “You don’t know how he’s walking around, much less being the most energetic person any of us have ever met,” he said.
While Kennedy’s comments about Trump’s diet were sharp, he later struck a more positive tone about the president’s overall health. He said that, in his view, Trump is in excellent physical condition and does not always eat poorly.
“I think he actually does eat pretty good food usually. He's got incredible health,” Kennedy said.
Kennedy also cited a medical assessment conducted by Dr Mehmet Oz, referencing Trump’s test results. According to Kennedy, Dr Oz reviewed Trump’s medical records and found unusually high testosterone levels for someone over 70. “He’s got the highest testosterone level that he’s ever seen for an individual over 70 years old,” Kennedy said, adding that Trump would likely be pleased to hear that repeated publicly.
Last month, the White House released details of an MRI scan that described Trump as being in “excellent health.” In a memo, Trump’s physician, Navy Captain Sean Barbabella, said the president’s cardiovascular system was in excellent condition, abdominal imaging was normal, and “all major organs appear very healthy and well-perfused.”
The medical disclosure came amid ongoing public scrutiny of Trump’s health, particularly as he is set to turn 80 in June and is the oldest person ever sworn in as US president.
The White House also addressed visible bruising on Trump’s right hand, explaining that it was linked to aspirin use as part of a standard heart-health regimen.
Following a recent checkup at Walter Reed National Military Medical Center, Trump’s physician described him as being in “exceptional health.” The evaluation, which lasted roughly three hours, included lab tests, advanced imaging, and preventive health assessments as part of his ongoing health maintenance plan.
During the visit, Trump also received his annual flu shot and a Covid-19 booster vaccine.
“President Donald J. Trump remains in exceptional health, exhibiting strong cardiovascular, pulmonary, neurological and physical performance,” Barbabella wrote in a one-page memo released by the White House.
The doctor also assessed Trump’s cardiac age, noting that it appeared to be about 14 years younger than his actual age. Trump is currently 79.
Despite questions around his fast-food-heavy diet, official medical reports continue to present a picture of a president who, by clinical measures at least, remains remarkably fit for his age.
Credits: AI Generated
A diet backed by scientific research may help people slim down while also bringing down high blood pressure. For those who have been told by their GP to lose weight, there are several eating plans and everyday changes that can support steady, healthy weight loss. One well-known approach is the DASH diet, created by researchers in the United States. Designed by the National Heart, Lung, and Blood Institute to help manage blood pressure, it has previously been described as the “best heart-healthy diet” and the “best diet for high blood pressure.”
The plan advises cutting back on salt while prioritising nutritious foods such as fruit, vegetables, and whole grains. According to nutritionist and author Robert Hobson, who wrote Unprocess Your Life, this way of eating may also support weight loss.
Speaking to Saga Magazine, Hobson explained: “The DASH (Dietary Approaches to Stop Hypertension) diet is similar to the Mediterranean diet, as it focuses on fruits, vegetables, lean protein, and keeping salt, sugar, and fat intake low. Research shows it can significantly reduce high blood pressure. Although it wasn’t created as a weight-loss plan, many people following DASH do end up losing weight.”
Many people report losing weight while following the DASH diet, particularly if they also lower their overall calorie intake. Studies suggest weight loss can range from modest to more noticeable levels, with one piece of research showing an average loss of 3.8kg in eight weeks when compared with other diets. This is often because the DASH diet centres on low-calorie foods like fruit and vegetables. Long-term commitment is key for lasting benefits, according to The Mirror.
The National Heart, Lung, and Blood Institute explains that no special or hard-to-find foods are needed to follow the DASH diet. Instead, people are encouraged to eat specific portions from each food group, based on their daily calorie requirements. The diet also stresses choosing foods that are low in saturated and trans fats, as well as lower in sodium.
Further guidance is available online, and the British Heart Foundation also offers advice and recipe ideas for those following the DASH diet. Outlining the potential benefits, the charity notes on its website: “A large study published in 2019 in the journal Nutrients reviewed seven meta-analyses, including 15 observational studies and 31 controlled trials, on the DASH diet.
“It found the diet was associated with a 5.2mmHg reduction in systolic blood pressure, which is the top number, and a 2.6mmHg reduction in diastolic blood pressure, the bottom number.”
The NHS states that the recommended daily calorie intake is around 2,500 calories for men and 2,000 calories for women. Anyone with health concerns should always speak to their GP.
For maintaining a balanced, healthy diet, the NHS advises: “If you’re eating foods and drinks high in fat, salt, or sugar, try to have them less often and in smaller portions. Aim to eat a wide variety of foods from the five main food groups to ensure you get a broad range of nutrients.”
© 2024 Bennett, Coleman & Company Limited