A revolutionary study published in BJPsych Open has revealed compelling evidence that a ketogenic diet can have a major impact on mental and physical well-being in bipolar disorder patients. The study, conducted by Dr. Iain Campbell, PhD, Baszucki Metabolic Psychiatry Research Fellow at the University of Edinburgh, investigates how a metabolic-based intervention might represent an exciting new strategy for treating this serious mental illness.

The research is the first in Europe to use neuroimaging methods, namely magnetic resonance spectroscopy (MRS), to investigate changes in brain metabolism in people with bipolar disorder after a ketogenic diet. The imaging findings revealed decreases in excitatory neurotransmitters, which are normally increased in bipolar disorder. This indicates that the ketogenic diet can stabilize brain activity, possibly reducing mood swings and other symptoms of the condition.

The trial involved 27 participants diagnosed with bipolar disorder, 20 of whom successfully completed the 6-8 week program. A staggering 91% of these individuals maintained ketosis, the metabolic state where the body primarily burns fat for energy instead of carbohydrates. Those who provided consistent daily ketone and mental health assessments reported notable improvements in mood, energy levels, anxiety, and impulsivity.

Dr. Campbell, who personally adheres to a ketogenic diet himself in order to treat symptoms of bipolar disorder, discussed the importance of these results:

"We saw indicators of diminished excitotoxicity in the brain regions most implicated in bipolar disorder. These findings are consistent with the metabolic overdrive hypothesis that postulates energy dysregulation within the brain as central to the disorder. Treating the dysregulation by means of a ketogenic diet could be a game-changer in treatment-resistant patients.

Aside from the scientific evidence, personal accounts of study participants underscore the life-altering effect of a ketogenic diet.

"Quite literally, for the first time in years, I felt like my brain was finally fueled correctly," explained a participant.

Another participant called the diet "a lifeline, restoring my energy and sense of hope. I felt like I was finally healing my mind, not just coping with my bipolar symptoms."

One of the very vivid accounts described the impact of ketosis in terms of a relaxing mental atmosphere:

"Applying a ketogenic diet is akin to giving my mind a nice warm bath. The edginess disappears. I am more calm, more clear, and my brain function is restored again."

Aside from the psychological benefits of the study, the ketogenic diet was also seen to have beneficial effects on participants' physical health. Nineteen out of the 20 trial completers lost a total of 9.3 pounds (4.2 kg) on average and showed improvements in body mass index (BMI) and blood pressure.

These results are noteworthy in that numerous treatments for bipolar disorder, such as mood stabilizers and antipsychotic medications, have been linked to metabolic side effects of weight gain and risk of cardiovascular disease. In contributing to the reduction of such risks, a ketogenic diet may provide a double dividend for patients with bipolar disorder.

Link Between Metabolism and Bipolar Disorder

Although the ketogenic diet has previously been known largely for its utility in treating epilepsy that is treatment-resistant, it is a somewhat new area to explore in conditions of psychiatry such as in bipolar disorder. It has come to be known that metabolic imbalance is an underlying factor in causing psychiatric disorders as energy production deficiencies have been recognized to contribute towards neural excitability and mood disruption.

One of the important findings of the study is that people with bipolar disorder tend to have sodium levels higher than usual within their cells. Lithium, a standard mood stabilizer, acts partly by reducing these sodium levels. The ketogenic diet seems to do the same thing, offering a metabolic explanation for its beneficial effect on mood stabilization.

What Is a Ketogenic Diet?

The ketogenic diet is a high-fat, low-carb diet that changes the body's main source of energy from glucose to ketones. As carbohydrate consumption is significantly decreased, the liver breaks down fats into ketones, which can be used as a substitute fuel by the brain and body.

First developed in the 1920s as a therapy for epilepsy, the ketogenic diet has been researched for its therapeutic applications in a variety of neurological and psychiatric disorders, including Alzheimer's disease, Parkinson's disease, and most recently, bipolar disorder.

There's a critical need for bigger replication studies and well-designed randomized clinical trials to follow up on these findings," added Dr. Campbell. "Our findings indicate that a ketogenic diet may be a useful adjunctive treatment for bipolar disorder, bringing new promise to patients who have difficulty with standard therapies.

Food is arguably one of the most important parts of life, as it is essentially the fuel that the body runs on. Food is so important to life that slight complications, changes, or missteps can cause great harm to you. If the food is unsafe, then that can act like poison as well. According to the World Health Organization (WHO), unsafe food causes around 866 million illnesses and 1.5 million deaths every year.

The WHO, in its recent report, reveals that children under 5 years of age experience 29 per cent of the health burden due to unsafe food, with 143,000 deaths in 2021.

WHO Director-General Dr Tedros Adhanom Ghebreyesus said, “Food safety is not an abstract issue – it touches every meal, every family, every day. Unsafe food has always been a major public health concern, but until now, we lacked the bigger picture of its staggering human and economic toll. These new estimates change that.”

Thus, it is crucial to know what to eat, how to eat, and protect yourself from foodborne diseases. And there is a strong connection between unsafe food and food myths; misunderstandings in the kitchen can cost you dearly, so knowing popular food myths from the global health body, WHO, is crucial.

5 Dangerous Food Safety Myths

Can You Tell If Food Is Safe To Eat By Its Look And Smell?

People often think that the smell and appearance of food can help us know its condition, but it's a complete hoax, as the WHO reports that most microorganisms that can make you sick don’t change the look or smell of the food.

Should Raw Poultry Be Washed Before Cooking?

This is arguably one of the popular food-related misconceptions, as in most households, the washing of chicken before cooking is seen as a healthy practice emphasizing making sure that the raw meat has been properly washed and soaked, but the WHO's report proves otherwise. The global body, washing poultry can spread harmful microorganisms to hands, surfaces, utensils, or other food.

Do Organic Fruits And Vegetables Need To Be Washed?

Some think that fruits and vegetables grown organically do not require washing, as they are not cooked with pesticides or chemical fertilizers, and that is a myth. The WHO said all produce, including organic, should be washed with clean water to remove physical contaminants and reduce the risk from any harmful microorganisms or chemicals.

Can Dishcloths Spread Dangerous Bacteria?

Another common habit is to use dishcloths to clean them after washing, and that is a big no from WHO, as dishcloths and sponges can carry and spread dangerous bacteria.

Do I Have To Refrigerate Leftover Food?

Sometimes people do not keep leftover food outside the refrigerator, and that is also a mistake because food can be dangerous to consume if left at room temperature for more than two hours.

Prediabetes affects more than 600 million people worldwide and is linked not only to an increased risk of type 2 diabetes but also to impaired brain function.

Adding a small quantity of almonds to the daily diet on their own or added to cereal, yogurt, curries, salads, and other dishes may help boost brain health and prevent a decline in cognitive function in adults with prediabetes, experts said.

Almonds contain

• protein
• fiber
• saturated fat and unsaturated fat
• 24 essential nutrients, including magnesium, potassium, and vitamin E.

The findings showed that eating just a few almonds each day may benefit cognitive performance, metabolic health, and markers of inflammation and oxidative stress in middle-aged Asian Indian adults with prediabetes.

“Adults with prediabetes are vulnerable to a decline in cognitive function. Our study indicates that just one simple dietary change – adding a small quantity of almonds to the daily diet – may help support brain health and improve cognitive performance in some populations,” said Dr. Anoop Misra, co-investigator and Chairman, Fortis-CDOC Center of Excellence for Diabetes, Metabolic Diseases, and Endocrinology in New Delhi, part of the study.

He noted that daily almond consumption could help lower the risk of prediabetes progressing to type 2 diabetes, a condition associated with an increased risk of dementia.

How Was The Study Conducted?

Also read: Unsafe Food Causes 1.5 Million Deaths Annually; Children Under 5 Face 3x Higher Risk: WHO

In a 24-week study, 60 Asian Indian adults aged 40–60 with prediabetes were assigned to either a control group or an almond group.

Those in the almond group consumed 32–42 grams of almonds daily as part of a calorie-matched diet.

Researchers assessed cognitive performance, blood sugar levels, cholesterol, weight, BMI, and waist circumference before and after the study.

What Did Researchers Find?

Participants in the almond group experienced improvements in executive function and processing speed, both key measures of cognitive performance.

They also demonstrated better blood sugar control, including lower fasting blood glucose, lower blood glucose levels two hours after eating, and improvements in HbA1c, a marker of long-term blood sugar control.

Additional metabolic benefits included significant reductions in body weight, body fat, BMI, waist circumference, total cholesterol, and LDL cholesterol.

Read More: PM Modi’s Push To Reduce Oil Intake Key To Fighting India’s Obesity And Diabetes Crisis, Say Experts

Participants consuming almonds also showed improvements in markers related to inflammation and oxidative stress.

“The findings showing improvements in cognitive function, blood sugar control, body weight, and cholesterol levels reinforce the role of almonds as a superfood. Their versatility and convenience make them an easy addition to everyday eating habits, while also providing important nutrients that support overall well-being,” said Ritika Samaddar, Regional Head, Department of Clinical Nutrition and Dietetics, Max Healthcare.

“Inflammation and oxidative stress are associated with cognitive decline. Our study found those in the almond group had lower levels of both, along with higher levels of a protective antioxidant (Vitamin E), compared with the control group,” said Dr. Seema Gulati, lead researcher of the study and Head of the Nutrition Research Group at the National Diabetes, Obesity and Cholesterol Foundation in New Delhi.

Chronic inflammation can cause major diseases like type 2 diabetes, cardiovascular disease, and cancer; thus, while thinking about staying healthy for a long time, it is a very important part of it. The disease is also a silent one that silently harms tissues over time and serves as a major reason for lifestyle conditions like Type 2 diabetes, obesity, and heart disease. Thus, reversing it becomes very important,

Recent study by researchers at Ohio State University, published in the journal Molecular Nutrition and Food Research, is a ray of hope for reversing this issue through dietary changes. The study finds that the drinking of specially formulated tomato-soy juice may reduce inflammation.

How Does Tomato-Soy Juice Fight Inflammation?

This beverage has a couple of potent reasons behind its success in the study against inflammation, namely lycopene and soy isoflavones. Notably, lycopene has antioxidant and carotenoid properties that enable it to neutralize free radicals, which cause cellular damage and fuel chronic inflammation. On the other hand, soy isoflavones possess plant-based nutrients called flavonoids, which have unique anti-inflammatory properties that can copy or modulate hormone signaling to calm overactive immune responses.

How Soy Helps Reduce High BP?

Those taking soy foods around 60–80 grams daily can expect a 28–29 per cent reduction in blood pressure. One hundred grams of soy is roughly equivalent to one cup of cooked beans or lentils, or a palm-sized serving of tofu. Higher soy consumption led to a 19 per cent lower risk of hypertension. Soy foods additionally contain compounds called isoflavones, which may further contribute to blood pressure regulation.

The study shows that tomato-soy juice reduced three major pro-inflammatory proteins in the blood, including interleukin-12 (IL-12p70), interleukin-5 (IL-5), and granulocyte-macrophage colony-stimulating factor (GM-CSF). The drink also lowers tumor necrosis factor-alpha (TNF-α), which is linked with chronic inflammatory diseases.

Read Also: Is Soy A Healthy Addition To Your Diet?

Are Soya Chunks Good For Gut Health?

Soy foods may support heart health. It is believed to reduce inflammation in blood vessels and improve their flexibility, lowering the risk of heart disease and stroke. Some studies even link soy consumption to a 15 percent lower risk of death from heart disease.

The ‘high-protein’ tag attached to soy products such as soya nuggets, soya chaap, and even soy milk is misleading. As industrially processed foods often contain 80 to 90 percent refined flour, consumers get empty calories that spike blood sugar, disrupt hormonal balance, and fuel inflammation.