A revolutionary study published in BJPsych Open has revealed compelling evidence that a ketogenic diet can have a major impact on mental and physical well-being in bipolar disorder patients. The study, conducted by Dr. Iain Campbell, PhD, Baszucki Metabolic Psychiatry Research Fellow at the University of Edinburgh, investigates how a metabolic-based intervention might represent an exciting new strategy for treating this serious mental illness.

The research is the first in Europe to use neuroimaging methods, namely magnetic resonance spectroscopy (MRS), to investigate changes in brain metabolism in people with bipolar disorder after a ketogenic diet. The imaging findings revealed decreases in excitatory neurotransmitters, which are normally increased in bipolar disorder. This indicates that the ketogenic diet can stabilize brain activity, possibly reducing mood swings and other symptoms of the condition.

The trial involved 27 participants diagnosed with bipolar disorder, 20 of whom successfully completed the 6-8 week program. A staggering 91% of these individuals maintained ketosis, the metabolic state where the body primarily burns fat for energy instead of carbohydrates. Those who provided consistent daily ketone and mental health assessments reported notable improvements in mood, energy levels, anxiety, and impulsivity.

Dr. Campbell, who personally adheres to a ketogenic diet himself in order to treat symptoms of bipolar disorder, discussed the importance of these results:

"We saw indicators of diminished excitotoxicity in the brain regions most implicated in bipolar disorder. These findings are consistent with the metabolic overdrive hypothesis that postulates energy dysregulation within the brain as central to the disorder. Treating the dysregulation by means of a ketogenic diet could be a game-changer in treatment-resistant patients.

Aside from the scientific evidence, personal accounts of study participants underscore the life-altering effect of a ketogenic diet.

"Quite literally, for the first time in years, I felt like my brain was finally fueled correctly," explained a participant.

Another participant called the diet "a lifeline, restoring my energy and sense of hope. I felt like I was finally healing my mind, not just coping with my bipolar symptoms."

One of the very vivid accounts described the impact of ketosis in terms of a relaxing mental atmosphere:

"Applying a ketogenic diet is akin to giving my mind a nice warm bath. The edginess disappears. I am more calm, more clear, and my brain function is restored again."

Aside from the psychological benefits of the study, the ketogenic diet was also seen to have beneficial effects on participants' physical health. Nineteen out of the 20 trial completers lost a total of 9.3 pounds (4.2 kg) on average and showed improvements in body mass index (BMI) and blood pressure.

These results are noteworthy in that numerous treatments for bipolar disorder, such as mood stabilizers and antipsychotic medications, have been linked to metabolic side effects of weight gain and risk of cardiovascular disease. In contributing to the reduction of such risks, a ketogenic diet may provide a double dividend for patients with bipolar disorder.

Link Between Metabolism and Bipolar Disorder

Although the ketogenic diet has previously been known largely for its utility in treating epilepsy that is treatment-resistant, it is a somewhat new area to explore in conditions of psychiatry such as in bipolar disorder. It has come to be known that metabolic imbalance is an underlying factor in causing psychiatric disorders as energy production deficiencies have been recognized to contribute towards neural excitability and mood disruption.

One of the important findings of the study is that people with bipolar disorder tend to have sodium levels higher than usual within their cells. Lithium, a standard mood stabilizer, acts partly by reducing these sodium levels. The ketogenic diet seems to do the same thing, offering a metabolic explanation for its beneficial effect on mood stabilization.

What Is a Ketogenic Diet?

The ketogenic diet is a high-fat, low-carb diet that changes the body's main source of energy from glucose to ketones. As carbohydrate consumption is significantly decreased, the liver breaks down fats into ketones, which can be used as a substitute fuel by the brain and body.

First developed in the 1920s as a therapy for epilepsy, the ketogenic diet has been researched for its therapeutic applications in a variety of neurological and psychiatric disorders, including Alzheimer's disease, Parkinson's disease, and most recently, bipolar disorder.

There's a critical need for bigger replication studies and well-designed randomized clinical trials to follow up on these findings," added Dr. Campbell. "Our findings indicate that a ketogenic diet may be a useful adjunctive treatment for bipolar disorder, bringing new promise to patients who have difficulty with standard therapies.

Coffee is one of the world’s most widely consumed beverages and has been linked to various health benefits, including a lower risk of conditions such as type 2 diabetes and cardiovascular disease. However, the biological mechanisms behind these benefits remain unclear.

Now, a Finnish study suggests that people who regularly drink coffee may have healthier body composition and metabolic markers.

The study, published in the European Journal of Nutrition, also found distinct associations between coffee consumption and sex hormones in men and women.

What Did The Study Find?

Researchers from the University of Oulu in Finland analyzed data from 2,264 participants, all aged 46, from the Northern Finland Birth Cohort 1966. They examined how coffee consumption was associated with circulating metabolites, cardiometabolic risk markers and sex hormones.

Coffee Linked To Leaner Body Profiles

Compared with people who drank less coffee, those who consumed more had:

• Lower total body fat
• Lower visceral fat
• Greater skeletal muscle mass

These biomarkers have previously been linked to insulin resistance and an increased risk of type 2 diabetes when chronically elevated.

Coffee And Sex Hormones

The strongest sex-specific associations were observed in men. Among men, higher coffee consumption was linked to:

• A more favorable glucose-insulin profile
• Higher concentrations of total and bioavailable testosterone
• Increased levels of sex hormone-binding globulin (SHBG)
• At the same time, free testosterone and the free androgen index were modestly lower.

What Could Explain The Link?

The researchers stated that hormonal pathways may partly explain the relationship between coffee consumption and metabolic health.

“What stood out in our findings was a distinct hormonal signature that didn't disappear even after we took into account BMI and lifestyle factors, with several of these associations differing between men and women,” said lead author Luca Verroest, a doctoral researcher at the University of Oulu.

More Research Is Needed

However, the findings do not prove that drinking coffee directly makes people leaner or healthier. The study was observational, meaning it identified associations between coffee consumption and metabolic measures rather than establishing cause and effect.

Further research is needed to determine whether coffee itself contributes to these differences in body composition and metabolic health.

How Much Coffee Is Good For You?

According to a recent scientific statement from the American Heart Association (AHA), published in the peer-reviewed journal Circulation, for most healthy adults, drinking up to five cups of black caffeinated coffee a day — providing up to 400 mg of caffeine — is considered safe and may even benefit heart health.

However, the statement noted that how coffee is brewed could make a difference, not just for its taste but also for cholesterol levels.

A review of the latest evidence on caffeine and cardiovascular health found that brewing methods matter because some types of coffee contain compounds that can raise LDL, or “bad,” cholesterol.

The review also found that drinking three to five 8-ounce cups of regular black coffee daily was associated with a lower risk of:

Heart disease

Stroke

Heart failure

Type 2 diabetes

Some abnormal heart rhythms.

For decades, people have been advised to avoid full-fat dairy over concerns that it could contribute to weight gain and higher cholesterol levels. Now, a new, albeit small, study challenges that view. It found that three daily servings of full-fat dairy did not worsen weight or cholesterol and may even offer some health benefits.

The study, led by researchers at the University of Toronto, found that adults who consumed three servings of full-fat dairy each day did not experience adverse changes in blood cholesterol, blood lipids or insulin resistance. The findings were published in The Journal of Nutrition.

"Those that had three servings of dairy didn't have adverse levels of blood cholesterol or lipids or evidence of insulin resistance," said Professor Harvey Anderson of the University of Toronto.

Why Full-Fat Dairy Has Long Raised Concerns

Dairy foods contain saturated fat, which has traditionally been associated with higher cholesterol and an increased risk of cardiovascular disease.

As a result, dietary recommendations in Canada and many other countries have generally encouraged people to choose fat-free or low-fat dairy products to reduce saturated fat intake.

However, Anderson, a professor of nutritional sciences at the University of Toronto's Temerty Faculty of Medicine, said human research has not always supported these concerns.

Numerous human studies have found no link between full-fat dairy consumption and harmful health outcomes.

What Did the Study Find?

To examine the link, the 12-week study included 74 adults with overweight or obesity who were randomly assigned to one of three dietary groups:

• A low-dairy, calorie-restricted diet
• An energy-neutral diet that included three servings of dairy each day
• An unrestricted diet that also included three daily servings of dairy

After 12 weeks, researchers found no meaningful differences in weight gain, body composition or cholesterol levels between people following the low-dairy diet and those consuming three servings of dairy each day.

On the other hand, people consuming more dairy showed improvements in blood pressure and consumed more calcium, protein, and vitamin D.

The reason may be the "dairy matrix hypothesis," the researchers said. This suggests that the health effects of a food may depend on how its components interact rather than simply on the amount of one nutrient it contains.

"With dairy products, it's got two proteins -- casein and whey -- that are bound together with fat and with nutrients mixed in," Anderson said.

According to Anderson, this complex structure allows nutrients in dairy foods to be delivered to the body gradually. That may help explain why the effects of eating dairy can differ from what would be predicted by looking at saturated fat or other individual nutrients in isolation.

Why This May Be Helpful for Older Adults

Anderson said the findings may be particularly relevant for older adults. As people age, they generally require less energy and may struggle to consume enough protein and other essential nutrients while maintaining an appropriate calorie intake.

Dairy is already a familiar food for many older adults and provides energy, protein and other nutrients. Anderson said it could therefore offer a practical way to help meet nutritional needs without increasing the risk of diabetes or other chronic diseases.

More broadly, the findings support an approach to nutrition research and dietary guidance that considers whole foods rather than focusing primarily on individual nutrients.

With nutrition trends constantly changing and dietary advice sometimes appearing contradictory, Anderson offered a simple message: "Keep it simple, eat a variety of foods and not too much of anything."

Paneer has long been a staple in Indian households, valued for its high protein content and versatility. However, growing concerns over food adulteration and the increasing availability of cheaper alternatives have brought analogue paneer into the spotlight.

While both products may look similar on the plate, they differ significantly in how they are made, their nutritional value, and their potential impact on health.

Real Paneer Vs Analogue Paneer

Real paneer is made by curdling milk. It naturally contains dairy protein (casein), calcium, and other milk nutrients.

The nutritional differences between the two can be significant. While genuine paneer provides complete protein and beneficial dairy nutrients, analogue paneer may contain lower-quality protein, higher amounts of unhealthy fats, sodium, and food additives depending on its formulation.

Regular consumption of heavily processed versions, particularly those high in trans fats or saturated fats, could contribute to long-term health concerns when eaten frequently as part of an unhealthy diet.

That said, not all analogue paneer products are nutritionally poor, making it important for consumers to read ingredient labels and choose products carefully.

Analogue paneer is typically made using vegetable fats/oils, starches, emulsifiers, and other additives to mimic paneer's texture and appearance. It is often cheaper and may contain substantially less protein than real paneer.

If someone regularly eats analogue paneer believing it is real paneer:

• They may consume less protein and calcium than expected, especially if paneer is a major protein source in their diet.
• Some products may contain higher amounts of refined starch, sodium, saturated fat, or hydrogenated fats, depending on formulation.
• Over years, frequent intake of products rich in trans fats or poor-quality fats could contribute to worse cholesterol levels and cardiovascular risk.
• The biggest issue is often mislabeling: people think they are getting the nutritional benefits of dairy paneer when they are not.

Also read: Why Has FSSAI Banned The Sale Of Dabur India's Ghee, Honey & Other Products?

What Happens If You Eat Analogue Paneer?

That said, not all analogue paneer is inherently harmful. When manufactured properly and clearly labeled, it is a legal food product. The health impact depends on its ingredients and how often it is consumed.

Occasional consumption is unlikely to be a major problem for most healthy people. However, people with heart disease, high cholesterol, diabetes, or those trying to maintain a balanced diet may benefit from choosing traditional paneer more often.

Understanding what goes into the food we eat and making informed choices can help ensure that convenience does not come at the cost of good nutrition.

By Dr. Aakash Patel, Internal Medicine, Sterling Hospital, Gandhidham