A revolutionary study published in BJPsych Open has revealed compelling evidence that a ketogenic diet can have a major impact on mental and physical well-being in bipolar disorder patients. The study, conducted by Dr. Iain Campbell, PhD, Baszucki Metabolic Psychiatry Research Fellow at the University of Edinburgh, investigates how a metabolic-based intervention might represent an exciting new strategy for treating this serious mental illness.

The research is the first in Europe to use neuroimaging methods, namely magnetic resonance spectroscopy (MRS), to investigate changes in brain metabolism in people with bipolar disorder after a ketogenic diet. The imaging findings revealed decreases in excitatory neurotransmitters, which are normally increased in bipolar disorder. This indicates that the ketogenic diet can stabilize brain activity, possibly reducing mood swings and other symptoms of the condition.

The trial involved 27 participants diagnosed with bipolar disorder, 20 of whom successfully completed the 6-8 week program. A staggering 91% of these individuals maintained ketosis, the metabolic state where the body primarily burns fat for energy instead of carbohydrates. Those who provided consistent daily ketone and mental health assessments reported notable improvements in mood, energy levels, anxiety, and impulsivity.

Dr. Campbell, who personally adheres to a ketogenic diet himself in order to treat symptoms of bipolar disorder, discussed the importance of these results:

"We saw indicators of diminished excitotoxicity in the brain regions most implicated in bipolar disorder. These findings are consistent with the metabolic overdrive hypothesis that postulates energy dysregulation within the brain as central to the disorder. Treating the dysregulation by means of a ketogenic diet could be a game-changer in treatment-resistant patients.

Aside from the scientific evidence, personal accounts of study participants underscore the life-altering effect of a ketogenic diet.

"Quite literally, for the first time in years, I felt like my brain was finally fueled correctly," explained a participant.

Another participant called the diet "a lifeline, restoring my energy and sense of hope. I felt like I was finally healing my mind, not just coping with my bipolar symptoms."

One of the very vivid accounts described the impact of ketosis in terms of a relaxing mental atmosphere:

"Applying a ketogenic diet is akin to giving my mind a nice warm bath. The edginess disappears. I am more calm, more clear, and my brain function is restored again."

Aside from the psychological benefits of the study, the ketogenic diet was also seen to have beneficial effects on participants' physical health. Nineteen out of the 20 trial completers lost a total of 9.3 pounds (4.2 kg) on average and showed improvements in body mass index (BMI) and blood pressure.

These results are noteworthy in that numerous treatments for bipolar disorder, such as mood stabilizers and antipsychotic medications, have been linked to metabolic side effects of weight gain and risk of cardiovascular disease. In contributing to the reduction of such risks, a ketogenic diet may provide a double dividend for patients with bipolar disorder.

Link Between Metabolism and Bipolar Disorder

Although the ketogenic diet has previously been known largely for its utility in treating epilepsy that is treatment-resistant, it is a somewhat new area to explore in conditions of psychiatry such as in bipolar disorder. It has come to be known that metabolic imbalance is an underlying factor in causing psychiatric disorders as energy production deficiencies have been recognized to contribute towards neural excitability and mood disruption.

One of the important findings of the study is that people with bipolar disorder tend to have sodium levels higher than usual within their cells. Lithium, a standard mood stabilizer, acts partly by reducing these sodium levels. The ketogenic diet seems to do the same thing, offering a metabolic explanation for its beneficial effect on mood stabilization.

What Is a Ketogenic Diet?

The ketogenic diet is a high-fat, low-carb diet that changes the body's main source of energy from glucose to ketones. As carbohydrate consumption is significantly decreased, the liver breaks down fats into ketones, which can be used as a substitute fuel by the brain and body.

First developed in the 1920s as a therapy for epilepsy, the ketogenic diet has been researched for its therapeutic applications in a variety of neurological and psychiatric disorders, including Alzheimer's disease, Parkinson's disease, and most recently, bipolar disorder.

There's a critical need for bigger replication studies and well-designed randomized clinical trials to follow up on these findings," added Dr. Campbell. "Our findings indicate that a ketogenic diet may be a useful adjunctive treatment for bipolar disorder, bringing new promise to patients who have difficulty with standard therapies.

Food allergy in children is becoming a more visible concern in Indian families, especially in urban settings where children are growing up with a different immune environment from earlier generations.

Less outdoor exposure, smaller families, more indoor living, frequent antibiotic use, air pollution, shifts in gut bacteria, packaged foods, and delayed introduction of certain foods may influence how the immune system learns tolerance. A food allergy happens when the body treats a harmless food protein as a threat and reacts against it.

Misleading Early Symptoms

The difficulty for parents is that many early symptoms look ordinary. Gas, bloating, or loose stools after a food may point to intolerance, which can be uncomfortable but is usually not dangerous.

An allergy tends to follow a more recognizable pattern involving hives, itching, swelling of the lips or eyes, repeated vomiting, coughing, wheezing, throat tightness, breathing difficulty, sudden tiredness or faintness soon after eating. In severe reactions, anaphylaxis can affect breathing and blood pressure, making it a medical emergency.

India adds another layer of complexity because possible triggers are often everyday foods. Milk, wheat, egg, peanut, fish, chickpea, lentils, and sesame are part of a child’s routine diet. Removing them altogether can deprive a growing child of protein, calories, and micronutrients, and ignoring repeated reactions can keep the child exposed to a genuine trigger. Both can harm the child.

What Should Parents Watch For

Parents should watch for patterns rather than fear every meal. If eczema flares, vomiting, wheezing, stomach pain, swelling, or rashes repeatedly appear after the same food, the child’s allergies should be evaluated.

A food diary is useful, but diagnosis cannot rest on home-based trial and error. The most important starting point is a careful clinical history: what was eaten, how quickly symptoms appeared, whether it happened again, and which body systems were involved. Based on this, a doctor may advise a skin prick test, serum-specific IgE test, or, in selected cases, a supervised oral food challenge.

The goal is simple: do not label every discomfort as an allergy, and do not dismiss repeated reactions as weak digestion. Children should remain confident around food while genuine triggers are identified, managed, and nutritionally replaced.

In India, more than one in four people has hypertension, and cumulatively, over 90 per cent of adults with hypertension are either undiagnosed, untreated, or treated but still live with uncontrolled blood pressure. Experts say this growing burden needs urgent attention.

In an interview with HealthandMe on World Hypertension Day 2026, Professor Vivekanand Jha, Executive Director of The George Institute for Global Health, suggested that one practical solution may be as simple as switching to potassium-enriched low-sodium salt substitutes (LSSS).

Current estimates show that Indians consume between 8 and 11 grams of salt (equivalent to 3.2–4.4 grams of sodium) per day — nearly double the World Health Organization recommended limit of 5 grams of salt (2 grams of sodium).

Low-sodium salt substitutes are composed of approximately 70–75 per cent sodium chloride and 25–30 per cent potassium chloride. They reduce sodium intake while increasing potassium consumption, helping lower blood pressure and reduce cardiovascular risk.

In January 2025, the World Health Organization released guidelines recommending potassium-enriched salt substitutes to combat hypertension and related heart risks. The guidelines suggest replacing regular table salt, which is high in sodium, with potassium-enriched alternatives that may help reduce noncommunicable diseases such as cardiovascular disease and chronic kidney disease by lowering blood pressure.

Dr Jha was also part of a consensus statement released by experts in clinical medicine, public health, and nutrition, recommending potassium-enriched low-sodium salt substitutes as an effective intervention to reduce hypertension and cardiovascular disease in India.

Here are excerpts from the interview:

Q. Is asking people to simply switch to a healthier salt more realistic than expecting them to completely change their diets?

Dr Jha: Public health works best when solutions fit naturally into people’s daily lives. Asking families to completely change what they eat is extremely difficult because food habits are emotional, cultural, and built over generations. But asking them to switch the type of salt they use at home is a much simpler and more achievable step. The taste remains familiar, cooking habits do not change, and yet the health benefits can begin immediately.

In a country like India, where a large proportion of sodium intake comes from salt added during cooking, this becomes a very practical intervention. It is not about perfection — it is about finding solutions that ordinary families can realistically adopt and sustain. There are, of course, other dietary factors that also need attention, such as excessive sugar intake, processed foods, and poor fruit consumption.

Q. High blood pressure medicines are often prescribed quickly. Are doctors giving enough importance to simple dietary changes like switching to healthier salt, or is prevention still underestimated?

Dr Jha: The answer is a definite no.

Our healthcare system is designed around managing disease once it appears, rather than reducing people’s need to come to hospitals by preventing disease in the first place.

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In a busy clinic, physicians often have only a few minutes with each patient, making detailed dietary counselling difficult. At the same time, advice like “eat less salt” can feel abstract or impractical for many patients. There are also systemic incentives that prioritize medicines over preventive care.

We need much stronger integration of nutrition and prevention into routine medical practice. If we truly want to reduce the burden of hypertension and its complications — including cardiovascular disease, stroke, and chronic kidney disease — prevention cannot remain an afterthought.

Q. Low-sodium salt may not suit some people with kidney disease or those on certain medicines. How can these risks be managed without discouraging the wider population from benefiting?

Dr Jha: This is an important conversation and needs to be handled responsibly and transparently. There is a small group of patients — particularly some people with advanced kidney disease or those on specific medications — for whom excess potassium may not be appropriate.

However, for the vast majority of the population, including many people with early-stage kidney disease, low-sodium salt substitutes are safe and beneficial. We have repeatedly shown this through modelling studies.

The challenge is ensuring that a legitimate caution for one group does not unintentionally discourage everyone else. That is why clear labelling, better awareness among healthcare professionals, and honest public communication are essential. Public health decisions are often about balancing risks and benefits, and in this case, the potential population-level benefits are very significant, including for a large majority of patients with chronic kidney disease.

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Q. Emerging evidence suggests increasing potassium may be as important as reducing sodium. Does this change how India should approach hypertension prevention?

Dr Jha: This is a very important point and broadens the conversation in a meaningful way. As it turns out, many physicians are also unaware that potassium intake among Indians is substantially lower than recommended, and that increasing potassium intake can help lower blood pressure and improve cardiovascular health.

What makes low-sodium salt substitutes particularly valuable is that they address both issues together — they reduce sodium while increasing potassium through a product people already use every day. This dual benefit could make a meaningful difference at scale.

It does not replace the need for healthier diets overall, but it does provide a practical and scalable public health tool.

Prime Minister Narendra Modi has recently urged Indian households to reduce their cooking oil consumption by at least 10 per cent.

While the appeal is part of a broader strategy to decrease India’s heavy reliance on imports, which currently accounts for 65 per cent of its edible oil needs, and comes amid the escalating Iran-US war, health experts said that this should become the norm in the country, burdened with chronic diseases.

High consumption of edible oils, particularly those high in saturated and trans fats like palm oil, is strongly linked to a higher risk of non-communicable diseases (NCDs) such as cardiovascular diseases, obesity, type 2 diabetes, and certain cancers.

These NCDs are also the leading cause of mortality in India, accounting for approximately 63–66 per cent of all deaths.

“Prime Minister Narendra Modi’s appeal to reduce oil consumption is not just a temporary health message, but a lifestyle habit every Indian family should adopt permanently. Excessive oil intake has become one of the major contributors to rising obesity, diabetes, hypertension, and heart disease cases in India, especially among younger populations,” Dr. Arvind Dambalkar, Senior Consultant & Head – Interventional Cardiology, Sarvodaya Hospital, Faridabad, told HealthandMe.

Dr. Madhu Nahar Roy, Director, Internal Medicine - Paras Health Udaipur, added that the message on reducing oil consumption is timely, especially as lifestyle diseases continue to rise across India.

PM Modi’s Call To Reduce Oil Intake

PM Modi first urged Indians to reduce cooking oil consumption by 10 per cent during his 79th Independence Day address, highlighting the need to tackle the rapidly rising burden of obesity and lifestyle diseases in India.

"In the coming years, obesity can become a major challenge for our country," the Prime Minister said. "If every family decides to reduce the use of cooking oil by 10 per cent, it will benefit the health of the nation."

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Again, in April, on World Health Day, he reiterated that adopting healthier eating habits, such as reducing oil usage, is “not just a personal decision but a social responsibility”.

He called for immediate action to prevent such a scenario and proposed a simple change: "I want to take a promise from you today that we all should reduce our cooking oil by 10 per cent. This will be a big step towards reducing obesity."

India's NCD Burden

India now ranks second globally in the number of overweight and obese children, according to the World Obesity Atlas.

If current trends continue, nearly 56 million children in the country could be affected by 2040.

As per the International Diabetes Federation’s Diabetes Atlas, India has 89.8 million adults diagnosed with diabetes, with projections suggesting that number will grow to a massive 156.7 million in 2050.

Further, in India, more than 1 in 4 people have hypertension, and cumulatively, more than 90 per cent of adults with hypertension are either undiagnosed, untreated, or treated but live with uncontrolled hypertension.

At the same time, cardiovascular disease (CVD) is the leading cause of mortality in India, accounting for nearly 28 per cent of all deaths and 45 per cent of NCD deaths.

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The Ideal Amount of Oil And Mode of Cooking

Dr. Arvind noted that fried and processed foods increase unhealthy fat accumulation, disturb cholesterol levels, and put long-term stress on the heart.

“A family of four should limit edible oil consumption to around 3 to 4 liters per month, as recommended by health experts. Choosing balanced, home-cooked meals with controlled oil can significantly improve overall Cardiac Health,” he said.

The expert noted that refined oils are not inherently harmful, but excessive consumption and repeated reheating can increase unhealthy fat intake and inflammation.

“For Indian cooking, mustard oil is beneficial for traditional high-heat cooking due to its good fatty acid profile, olive oil works well for salads and light sautéing, while sunflower oil should be used in moderation and rotated with other oils,” Dr. Madhu told HealthandMe.

The expert also stated that adopting healthier cooking methods, such as air frying, steaming, roasting, and grilling, can help reduce excess calorie and fat consumption significantly.