A revolutionary study published in BJPsych Open has revealed compelling evidence that a ketogenic diet can have a major impact on mental and physical well-being in bipolar disorder patients. The study, conducted by Dr. Iain Campbell, PhD, Baszucki Metabolic Psychiatry Research Fellow at the University of Edinburgh, investigates how a metabolic-based intervention might represent an exciting new strategy for treating this serious mental illness.

The research is the first in Europe to use neuroimaging methods, namely magnetic resonance spectroscopy (MRS), to investigate changes in brain metabolism in people with bipolar disorder after a ketogenic diet. The imaging findings revealed decreases in excitatory neurotransmitters, which are normally increased in bipolar disorder. This indicates that the ketogenic diet can stabilize brain activity, possibly reducing mood swings and other symptoms of the condition.

The trial involved 27 participants diagnosed with bipolar disorder, 20 of whom successfully completed the 6-8 week program. A staggering 91% of these individuals maintained ketosis, the metabolic state where the body primarily burns fat for energy instead of carbohydrates. Those who provided consistent daily ketone and mental health assessments reported notable improvements in mood, energy levels, anxiety, and impulsivity.

Dr. Campbell, who personally adheres to a ketogenic diet himself in order to treat symptoms of bipolar disorder, discussed the importance of these results:

"We saw indicators of diminished excitotoxicity in the brain regions most implicated in bipolar disorder. These findings are consistent with the metabolic overdrive hypothesis that postulates energy dysregulation within the brain as central to the disorder. Treating the dysregulation by means of a ketogenic diet could be a game-changer in treatment-resistant patients.

Aside from the scientific evidence, personal accounts of study participants underscore the life-altering effect of a ketogenic diet.

"Quite literally, for the first time in years, I felt like my brain was finally fueled correctly," explained a participant.

Another participant called the diet "a lifeline, restoring my energy and sense of hope. I felt like I was finally healing my mind, not just coping with my bipolar symptoms."

One of the very vivid accounts described the impact of ketosis in terms of a relaxing mental atmosphere:

"Applying a ketogenic diet is akin to giving my mind a nice warm bath. The edginess disappears. I am more calm, more clear, and my brain function is restored again."

Aside from the psychological benefits of the study, the ketogenic diet was also seen to have beneficial effects on participants' physical health. Nineteen out of the 20 trial completers lost a total of 9.3 pounds (4.2 kg) on average and showed improvements in body mass index (BMI) and blood pressure.

These results are noteworthy in that numerous treatments for bipolar disorder, such as mood stabilizers and antipsychotic medications, have been linked to metabolic side effects of weight gain and risk of cardiovascular disease. In contributing to the reduction of such risks, a ketogenic diet may provide a double dividend for patients with bipolar disorder.

Link Between Metabolism and Bipolar Disorder

Although the ketogenic diet has previously been known largely for its utility in treating epilepsy that is treatment-resistant, it is a somewhat new area to explore in conditions of psychiatry such as in bipolar disorder. It has come to be known that metabolic imbalance is an underlying factor in causing psychiatric disorders as energy production deficiencies have been recognized to contribute towards neural excitability and mood disruption.

One of the important findings of the study is that people with bipolar disorder tend to have sodium levels higher than usual within their cells. Lithium, a standard mood stabilizer, acts partly by reducing these sodium levels. The ketogenic diet seems to do the same thing, offering a metabolic explanation for its beneficial effect on mood stabilization.

What Is a Ketogenic Diet?

The ketogenic diet is a high-fat, low-carb diet that changes the body's main source of energy from glucose to ketones. As carbohydrate consumption is significantly decreased, the liver breaks down fats into ketones, which can be used as a substitute fuel by the brain and body.

First developed in the 1920s as a therapy for epilepsy, the ketogenic diet has been researched for its therapeutic applications in a variety of neurological and psychiatric disorders, including Alzheimer's disease, Parkinson's disease, and most recently, bipolar disorder.

There's a critical need for bigger replication studies and well-designed randomized clinical trials to follow up on these findings," added Dr. Campbell. "Our findings indicate that a ketogenic diet may be a useful adjunctive treatment for bipolar disorder, bringing new promise to patients who have difficulty with standard therapies.

piece of sugar-free chewing gum may seem like a healthier choice. But new research is putting one of its most excessively used ingredients under the microscope: xylitol. It is a sugar alcohol used in sugar-free chewing gum, mints, toothpaste, jam, yoghurt, and other products.

The sugar-free sweetener has been linked with a significantly higher risk of heart attack, stroke and cardiovascular death in a large new study.

Researchers found that people with the highest blood levels of xylitol had a 57% higher risk of a major cardiovascular event over six years than those with the lowest levels.

The findings were presented at the European Society of Cardiology (ESC) Congress 2026. It was based on 17,710 people from two long-running population studies. The researchers also found an 18% higher risk over 30 years in the European group.

But before you throw every packet of sugar-free gum into the bin, remember that the study only found an association, not definitive proof that consuming xylitol directly increases the risk of heart attacks or strokes.

What Is Xylitol?

Xylitol is a sugar alcohol, also known as a polyol. It occurs naturally in tiny amounts in some foods and is also produced by the human body during glucose metabolism.

Xylitol tastes almost the same as sugar but contains fewer calories, and it does not promote tooth decay in the same way ordinary sugar does. That's why it has become a popular ingredient in sugar-free gum, mints, and other oral-care products.

According to the ESC, the concerning part is that commercially added amounts of xylitol can be more than 1,000 times higher than the tiny quantities naturally present in foods and the body.

Also read: FSSAI Proposes Red Front-Of-Pack Warning Labels On Junk Food: How Will This Benefit Consumers’ Health?

How Was Study Conducted?

Researchers divided participants according to their blood xylitol levels and compared the highest quarter with the lowest quarter.

In the Canadian cohort, those with the highest levels had a 57% greater risk of major adverse cardiovascular events over six years after adjusting age, sex, smoking, diabetes, blood pressure and cholesterol.

In the European cohort, the association remained visible over a much longer period, with an 18% higher risk over 30 years.

One of the most important findings is that 57% does not mean that eating a piece of xylitol gum makes your personal risk of a heart attack jump by 57%. The researchers measured xylitol circulating in the blood, rather than asking participants how much xylitol-containing food they consumed.

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Xylitol May Enable The Formation Of Blood Clots

The researchers had previously investigated how xylitol might influence blood clotting. Their laboratory work suggested that xylitol can make platelets more reactive, equipping them to form clots.

Dr Marco Witkowski of Charité University Hospital in Berlin, who presented the research, said, "Xylitol can enhance the ability of platelets to form clots."

When a blood clot blocks an artery supplying the heart, it can trigger a heart attack. If a clot blocks blood flow to part of the brain, it can cause an ischaemic stroke.

Witkowski added, "Our long-term findings highlight how little we know about the cardiovascular safety of xylitol."

The study does not establish that ordinary consumption of products containing xylitol causes heart attacks or strokes, and it does not mean that replacing sugar with xylitol is automatically dangerous.

Food choices play an important role in overall health, and reproductive health is no exception. Eating junk or highly processed foods occasionally is unlikely to directly cause infertility. However, regularly consuming foods that are high in added sugar, unhealthy fats, salt and refined carbohydrates, while being low in essential nutrients, may affect the body in several ways.

Poor dietary patterns can contribute to weight gain, insulin resistance, inflammation and hormonal changes, all of which may influence fertility. Both men and women can be affected, although the impact may differ depending on individual health, age and other factors.

The Link Between Diet, Weight And Hormonal Health

It can affect healthy body weight: Regular intake of calorie-dense foods such as fried snacks, fast food, sugary beverages and packaged foods can contribute to weight gain. Being significantly overweight or underweight can affect reproductive hormones. In women, excess weight may interfere with ovulation and menstrual regularity, while in men it may affect testosterone levels and sperm production.

It may influence blood sugar and insulin: A diet high in refined carbohydrates and added sugars can contribute to insulin resistance, particularly when combined with excess weight and low physical activity. Insulin resistance can worsen hormonal imbalance and may contribute to irregular ovulation in women, especially those with conditions such as PMOS (earlier known as PCOS).

Nutrient deficiencies can matter: Highly processed foods may provide calories without supplying enough important nutrients. Fertility and reproductive health require adequate amounts of proteins, healthy fats, vitamins and minerals such as folate, iron, zinc, selenium and vitamin D. A diet lacking variety may therefore not provide the nutritional support needed for healthy reproductive function.

Also read: For The First Time, Study Links 'One Sugary Drink A Day' To Higher Stomach Cancer Risk

Why Sperm Health And Overall Diet Matter Too

Sperm health can also be affected: In men, a consistently poor-quality diet may be associated with poorer sperm concentration, movement and quality. Diets rich in fruits, vegetables, whole grains, nuts, seeds, legumes, fish and other nutrient-rich foods are generally considered more supportive of reproductive health.

Inflammation and oxidative stress may play a role: Frequent consumption of highly processed foods, particularly those rich in unhealthy fats and added sugars, may contribute to inflammation and oxidative stress. These processes can affect overall health and may potentially influence egg and sperm quality.

Also read: Can What You Eat Before 9 AM Shape Your Blood Sugar For The Rest Of The Day?

Small Dietary Changes Can Support Reproductive Health

Small changes can make a difference: Improving fertility-supportive nutrition does not mean completely avoiding favourite foods. The focus should be on balance. Fresh fruits and vegetables, whole grains, pulses, nuts, seeds, dairy or suitable alternatives and adequate protein should form a regular part of the diet. Processed snacks, sugary drinks and deep-fried foods can be limited rather than consumed frequently.

Lifestyle matters along with diet: Diet is only one part of fertility. Regular physical activity, adequate sleep, stress management, avoiding smoking and excessive alcohol, and maintaining a healthy weight are also important. Existing conditions such as diabetes, thyroid disorders, or PMOS (earlier known as PCOS) should be properly managed.

Regular consumption of junk and highly processed foods does not automatically mean that a person will become infertile. However, when such foods form a large part of the daily diet, they may contribute to obesity, metabolic problems, nutritional deficiencies and hormonal changes that can affect reproductive health.

A balanced and nutrient-rich diet, combined with healthy lifestyle habits and timely management of medical conditions, can help create a healthier environment for fertility. If a couple is having difficulty conceiving, dietary changes should not replace a proper medical evaluation.

Drinking a sugary beverage every day may be linked to a significantly higher risk of stomach cancer, according to a new study that researchers described as the first of its kind.

The study found that people who consumed at least one sugar-sweetened beverage everyday had 2.45 times the risk of developing gastric cancer compared with those who consumed fewer drinks in a month.

The findings were based on data obtained from 112,284 participants enrolled in the Nurses' Health Study and Health Professionals Follow-Up Study. Over the follow-up period, 278 participants developed gastric cancer.

Researchers from Mass General Brigham Cancer Institute and other institutions published their findings in Gastro Hep Advances.

Daily Sugary Drinks Linked To Higher Stomach Cancer Risk

The researchers examined participants' intake of sugar-sweetened beverages, including regular soft drinks, punch, lemonade and sports drinks.

After accounting for other potential risk factors, people who drank at least one serving of these beverages every day had a 2.45-fold higher risk of gastric cancer than those who consumed them less than once a month.

The association was even stronger among women in the Nurses' Health Study. Women who consumed more than one sugary drink a day had a 3.04-fold higher risk of stomach cancer compared with women who rarely consumed them. The study did not find a similar association between artificially sweetened beverages and gastric cancer.

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Researchers Think Sugar And Fructose Are Possible Factors

The researchers also looked at participants' intake of fructose, a type of sugar commonly found in sweetened beverages. Higher fructose consumption was associated with a greater incidence of gastric cancer, although the study could not establish exactly why.

Excessive sugar consumption can contribute to several metabolic changes, including weight gain and inflammation, which are being investigated as possible pathways connecting sugary drinks with cancer. However, the researchers stressed that the biological mechanism behind the association is still not established.

Senior author Andrew T. Chan, a gastroenterologist and epidemiologist at Mass General Brigham, said the study addresses an area that has received relatively little attention.

“This is the first study to demonstrate an association between sugar-sweetened beverage intake and gastric cancer in a U.S. population.” Chan noted that stomach cancer remains a major global health burden and is the fifth leading cause of cancer death worldwide.

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H. Pylori Infection Maybe A Common Denominator

The researchers also considered Helicobacter pylori, or H. pylori, a bacterium and one of the most common risk factors for stomach cancer. Among a smaller group of 940 participants for whom information about H. pylori was available, more than one-third showed evidence of infection. However, researchers did not find a clear relationship between sugary-drink consumption and H. pylori infection.

This suggests that the association between sugary beverages and stomach cancer may not simply be explained by sugary drinks increasing the likelihood of H. pylori infection. More research is needed to understand the connection.

Study Does Not Prove Sugary Drinks Cause Cancer

The study was observational, meaning it identified an association but could not establish that consuming sugary drinks directly causes stomach cancer.

Researchers also pointed to several limitations, including limited information about H. pylori infection and family history of stomach cancer. Most participants were also white, which could limit how broadly the findings can be applied to other populations.