A revolutionary study published in BJPsych Open has revealed compelling evidence that a ketogenic diet can have a major impact on mental and physical well-being in bipolar disorder patients. The study, conducted by Dr. Iain Campbell, PhD, Baszucki Metabolic Psychiatry Research Fellow at the University of Edinburgh, investigates how a metabolic-based intervention might represent an exciting new strategy for treating this serious mental illness.

The research is the first in Europe to use neuroimaging methods, namely magnetic resonance spectroscopy (MRS), to investigate changes in brain metabolism in people with bipolar disorder after a ketogenic diet. The imaging findings revealed decreases in excitatory neurotransmitters, which are normally increased in bipolar disorder. This indicates that the ketogenic diet can stabilize brain activity, possibly reducing mood swings and other symptoms of the condition.

The trial involved 27 participants diagnosed with bipolar disorder, 20 of whom successfully completed the 6-8 week program. A staggering 91% of these individuals maintained ketosis, the metabolic state where the body primarily burns fat for energy instead of carbohydrates. Those who provided consistent daily ketone and mental health assessments reported notable improvements in mood, energy levels, anxiety, and impulsivity.

Dr. Campbell, who personally adheres to a ketogenic diet himself in order to treat symptoms of bipolar disorder, discussed the importance of these results:

"We saw indicators of diminished excitotoxicity in the brain regions most implicated in bipolar disorder. These findings are consistent with the metabolic overdrive hypothesis that postulates energy dysregulation within the brain as central to the disorder. Treating the dysregulation by means of a ketogenic diet could be a game-changer in treatment-resistant patients.

Aside from the scientific evidence, personal accounts of study participants underscore the life-altering effect of a ketogenic diet.

"Quite literally, for the first time in years, I felt like my brain was finally fueled correctly," explained a participant.

Another participant called the diet "a lifeline, restoring my energy and sense of hope. I felt like I was finally healing my mind, not just coping with my bipolar symptoms."

One of the very vivid accounts described the impact of ketosis in terms of a relaxing mental atmosphere:

"Applying a ketogenic diet is akin to giving my mind a nice warm bath. The edginess disappears. I am more calm, more clear, and my brain function is restored again."

Aside from the psychological benefits of the study, the ketogenic diet was also seen to have beneficial effects on participants' physical health. Nineteen out of the 20 trial completers lost a total of 9.3 pounds (4.2 kg) on average and showed improvements in body mass index (BMI) and blood pressure.

These results are noteworthy in that numerous treatments for bipolar disorder, such as mood stabilizers and antipsychotic medications, have been linked to metabolic side effects of weight gain and risk of cardiovascular disease. In contributing to the reduction of such risks, a ketogenic diet may provide a double dividend for patients with bipolar disorder.

Link Between Metabolism and Bipolar Disorder

Although the ketogenic diet has previously been known largely for its utility in treating epilepsy that is treatment-resistant, it is a somewhat new area to explore in conditions of psychiatry such as in bipolar disorder. It has come to be known that metabolic imbalance is an underlying factor in causing psychiatric disorders as energy production deficiencies have been recognized to contribute towards neural excitability and mood disruption.

One of the important findings of the study is that people with bipolar disorder tend to have sodium levels higher than usual within their cells. Lithium, a standard mood stabilizer, acts partly by reducing these sodium levels. The ketogenic diet seems to do the same thing, offering a metabolic explanation for its beneficial effect on mood stabilization.

What Is a Ketogenic Diet?

The ketogenic diet is a high-fat, low-carb diet that changes the body's main source of energy from glucose to ketones. As carbohydrate consumption is significantly decreased, the liver breaks down fats into ketones, which can be used as a substitute fuel by the brain and body.

First developed in the 1920s as a therapy for epilepsy, the ketogenic diet has been researched for its therapeutic applications in a variety of neurological and psychiatric disorders, including Alzheimer's disease, Parkinson's disease, and most recently, bipolar disorder.

There's a critical need for bigger replication studies and well-designed randomized clinical trials to follow up on these findings," added Dr. Campbell. "Our findings indicate that a ketogenic diet may be a useful adjunctive treatment for bipolar disorder, bringing new promise to patients who have difficulty with standard therapies.

Children who consume more ultra-processed foods may show stronger brain responses that could make them crave those foods repeatedly. This helps explain the link between these foods and childhood weight gain, according to a new study.

The research, published in JAMA Network Open, found that kids who ate more ultra-processed foods had greater activity in a brain region that is involved in reward and motivation when they saw tempting pictures of appetising foods. That brain activity was also associated with increase in body fat over the following year.

The findings raise important questions about how eating highly processed foods frequently may affect a developing brain.

UPFs May Influence A Developing Brain

Also read: Six To Eight Cups Of Tea A Day Linked To Lower Heart Disease Risk: But Should You Drink More?

The study included 46 children aged 7 to 10 who had a healthy weight at the beginning of the research. Scientists collected data about their diets and used functional magnetic resonance imaging (fMRI) to examine brain activity while the children viewed pictures of appetising foods, including cookies and French fries.

The researchers focused on the striatum, a brain region involved in learning, motivation and reward anticipation.

Children who consumed more ultra-processed foods showed stronger responses in the dorsal striatum when viewing food images. Greater activity in this region was also linked with an increase in body mass index (BMI) and body fat percentage one year later.

The researchers found that accounting for differences in brain responses weakened the association between ultra-processed food intake and subsequent increases in BMI by 31% and body fat percentage by 44%. This suggests that brain activity related to reward may help explain part of the relationship.

Senior study author Dr Kathleen A. Page, a professor of medicine and pediatrics at the Keck School of Medicine of the University of Southern California, said, “This study goes beyond just understanding that UPFs affect weight gain. It actually gives us insight into the neurobiological underpinnings by which these foods may be linked to body composition over time.”

Importance Of Childhood Nutrition

Also read: Peanut Consumption Associated With Lower Type 2 Diabetes Risk: Study Explains

Ultra-processed foods include many packaged snacks, sugary cereals, sweetened drinks, instant meals and other similar products. They are often designed to be convenient, appealing, and have a long shelf life.

The researchers say childhood is an important period for understanding how food habits influence eating patterns and long-term health.

“Children’s brains are still developing, habits are still forming and food preferences are still being made. It’s an important period where the brain is very sensitive to food and the food environment,” Page said.

The research had key limitations. It involved only 46 children, assessed brain activity at a single time point and followed changes in body composition for one year. The observational design means researchers cannot determine whether greater ultra-processed food consumption caused the brain responses or whether other factors contributed to both.

Message For Parents

The findings point to existing concerns about children's diets high in ultra-processed foods. Page emphasised the importance of making healthier options more accessible.

“Changing the food environment to help people access healthier, more minimally processed foods is an important part of the solution,” she said.

Families can offer more fruits, vegetables, whole grains, pulses and other minimally processed foods while limiting consumption of sugary drinks and packaged snacks.

Whey protein is one of the most heavily marketed supplements in the fitness world, but the actual science behind it is more modest than the gym lore suggests.

Muscle is constantly being broken down and rebuilt, and the balance between those two processes over weeks and months determines whether you gain or lose muscle.

Resistance training raises the rate of muscle rebuilding, called muscle protein synthesis, and eating protein raises it further. Whey, the liquid left over when milk becomes cheese, digests quickly and is naturally high in leucine, an amino acid that appears to help trigger that rebuilding process. In short-term lab studies, this gives whey a sharper spike in synthesis compared with slower-digesting proteins like casein.

A short-term spike doesn’t automatically mean more muscle over months, though. What actually matters for long-term gains is a different question: how much total protein someone eats in a day.

How Much Protein Do We Actually Need?

A widely cited 2018 meta-analysis in the British Journal of Sports Medicine, led by Robert Morton and colleagues at McMaster University, looked at this directly. Pooling 49 resistance training trials with 1,863 participants, the researchers found that protein supplementation significantly increased gains in strength, muscle mass, and muscle fibre size compared with resistance training alone.

The benefits levelled off once total daily protein intake reached roughly 1.62 grams per kilogram of body weight, the study found. Past that point, extra protein, from whey or any other source, mostly just becomes calories. For an 80-kilogram (176-pound) person, that threshold works out to about 130 grams of protein a day.

Also Read: Is Lemon Water Really Helpful for Preventing Kidney Stones?

Right Time To Consume Protein

The idea of a 30-minute “anabolic window” after a workout has largely fallen out of favour in the research. When studies control for how much protein people ate in total, tight timing around workouts shows little added benefit.

Total daily intake is what predicts outcomes, not whether a shake was consumed within a specific window after training. Spreading protein across three or four meals a day is a reasonable habit, but missing a post-workout shake by an hour or two makes little practical difference.

Where Whey Actually Fits

If someone’s diet already supplies enough protein from food, around that 1.6 g/kg mark, a shake adds little extra benefit. Whey becomes useful mainly as a convenient way to close a gap when a person’s diet otherwise falls short, particularly because of its speed, high leucine content, and long shelf life compared with whole-food protein sources like chicken, eggs, or fish.

A few groups should be cautious. People with kidney disease should talk to a doctor before raising protein intake, and whey, as a dairy product, isn’t suitable for anyone with a milk allergy. People with lactose intolerance may tolerate whey isolate, which has less lactose than concentrate, but should check with a clinician if unsure.

Whey builds muscle the same way other high-quality proteins do: by helping people hit a sufficient total daily protein target alongside resistance training. It isn’t a shortcut or a requirement, just one convenient tool among several for reaching the same number. Training remains the main driver of muscle growth. Protein, whey included, is what supports it.

Avid tea drinkers now have a reason to rejoice as drinking tea regularly may be linked with a lower risk of cardiovascular disease. A new study has found that people who drank around six to eight cups a day are at low risk. However, researchers warn that this does not mean everyone should increase their tea consumption.

Published in the Journal of Internal Medicine, the study examined data from 485,934 adults in China, aged 30 to 79. Over an average follow-up of about nine years, researchers identified 14,863 cases of cardiovascular and other vascular diseases, including heart attacks, strokes and peripheral artery disease.

Tea Drinkers At Lower Heart Disease Risk

People who drank tea at least three days a week had an approximately 11% lower risk of developing vascular disease than those who drank it less frequently.

The lowest estimated risk was observed among people who drank around six to eight cups daily. However, risk began to rise again at higher consumption levels.

The findings are based on an observational study. It means that they just show an association rather than proving that tea directly prevents heart disease. It is also important to note that participants reported their own habits of drinking tea, and researchers did not use a standard cup size.

Emergency physician Dr Leana Wen cautioned against interpreting the results and drinking multiple cups of tea as a daily target, according to CNN. She said, "People should not interpret this to mean that everyone should aim to drink six to eight cups of tea daily."

Also read: India Proposes Lower Pesticide Residue Limits In Tea Than US & Japan: What Are The Health Risks?

What Type Of Tea Is The Most Beneficial?

The study mostly found associations between black tea consumption and lower cardiovascular risk across different types of vascular disease. Green tea showed benefits for heart health, according to the study.

Black and green tea come from the same plant, Camellia sinensis, but the leaves are processed differently, resulting in different compositions of polyphenols.

Tea contains polyphenols, including flavonoids, which have antioxidant and anti-inflammatory properties. These compounds may help support blood vessel function. Some research has also linked tea consumption with improvements in blood pressure and cholesterol.

However, researchers cannot rule out other lifestyle factors. People who drink tea regularly may differ from non-drinkers in their diet, physical activity, smoking habits and other aspects of health.

Dr Wen said, “Both can be part of a heart-healthy diet — especially if people take care to drink them without added sugar.”

Also read: Mississippi Student Deaths Put Kratom Under Scrutiny: How Dangerous Is It?

Why You Should Avoid Drinking Tea Scalding Hot

The study also found that people who reported drinking tea at a “burning hot” temperature had a 16% higher risk of vascular disease than those who did not regularly drink tea.

The researchers trusted the participants' descriptions of their preferred drinking temperature, rather than measuring the temperature directly. The finding should therefore be interpreted accordingly.

There is another reason to let tea cool before drinking it. Repeated consumption of very hot beverages has been linked to an increased risk of oesophageal cancer.

Researchers Warn

The study does not prove that drinking more tea will lower an individual's risk of heart disease, and the findings may not apply in the same way to every population.

Additionally, tea also contains caffeine. An eight-ounce cup of black tea typically contains around 30 to 50 milligrams, while green tea generally contains less. Excessive caffeine intake can contribute to sleep problems, anxiety or palpitations. Pregnant people are generally advised to limit caffeine to 200 milligrams a day,.

Drinking unsweetened tea can be part of a daily diet, especially when it replaces sugary drinks. Apart from this, regular physical activity, avoiding smoking, maintaining healthy blood pressure and cholesterol levels, and eating a balanced diet still remain the basic ways to reduce cardiovascular risk.