A revolutionary study published in BJPsych Open has revealed compelling evidence that a ketogenic diet can have a major impact on mental and physical well-being in bipolar disorder patients. The study, conducted by Dr. Iain Campbell, PhD, Baszucki Metabolic Psychiatry Research Fellow at the University of Edinburgh, investigates how a metabolic-based intervention might represent an exciting new strategy for treating this serious mental illness.
The research is the first in Europe to use neuroimaging methods, namely magnetic resonance spectroscopy (MRS), to investigate changes in brain metabolism in people with bipolar disorder after a ketogenic diet. The imaging findings revealed decreases in excitatory neurotransmitters, which are normally increased in bipolar disorder. This indicates that the ketogenic diet can stabilize brain activity, possibly reducing mood swings and other symptoms of the condition.
The trial involved 27 participants diagnosed with bipolar disorder, 20 of whom successfully completed the 6-8 week program. A staggering 91% of these individuals maintained ketosis, the metabolic state where the body primarily burns fat for energy instead of carbohydrates. Those who provided consistent daily ketone and mental health assessments reported notable improvements in mood, energy levels, anxiety, and impulsivity.
Dr. Campbell, who personally adheres to a ketogenic diet himself in order to treat symptoms of bipolar disorder, discussed the importance of these results:
"We saw indicators of diminished excitotoxicity in the brain regions most implicated in bipolar disorder. These findings are consistent with the metabolic overdrive hypothesis that postulates energy dysregulation within the brain as central to the disorder. Treating the dysregulation by means of a ketogenic diet could be a game-changer in treatment-resistant patients.
Aside from the scientific evidence, personal accounts of study participants underscore the life-altering effect of a ketogenic diet.
"Quite literally, for the first time in years, I felt like my brain was finally fueled correctly," explained a participant.
Another participant called the diet "a lifeline, restoring my energy and sense of hope. I felt like I was finally healing my mind, not just coping with my bipolar symptoms."
One of the very vivid accounts described the impact of ketosis in terms of a relaxing mental atmosphere:
"Applying a ketogenic diet is akin to giving my mind a nice warm bath. The edginess disappears. I am more calm, more clear, and my brain function is restored again."
Aside from the psychological benefits of the study, the ketogenic diet was also seen to have beneficial effects on participants' physical health. Nineteen out of the 20 trial completers lost a total of 9.3 pounds (4.2 kg) on average and showed improvements in body mass index (BMI) and blood pressure.
These results are noteworthy in that numerous treatments for bipolar disorder, such as mood stabilizers and antipsychotic medications, have been linked to metabolic side effects of weight gain and risk of cardiovascular disease. In contributing to the reduction of such risks, a ketogenic diet may provide a double dividend for patients with bipolar disorder.
Although the ketogenic diet has previously been known largely for its utility in treating epilepsy that is treatment-resistant, it is a somewhat new area to explore in conditions of psychiatry such as in bipolar disorder. It has come to be known that metabolic imbalance is an underlying factor in causing psychiatric disorders as energy production deficiencies have been recognized to contribute towards neural excitability and mood disruption.
One of the important findings of the study is that people with bipolar disorder tend to have sodium levels higher than usual within their cells. Lithium, a standard mood stabilizer, acts partly by reducing these sodium levels. The ketogenic diet seems to do the same thing, offering a metabolic explanation for its beneficial effect on mood stabilization.
The ketogenic diet is a high-fat, low-carb diet that changes the body's main source of energy from glucose to ketones. As carbohydrate consumption is significantly decreased, the liver breaks down fats into ketones, which can be used as a substitute fuel by the brain and body.
First developed in the 1920s as a therapy for epilepsy, the ketogenic diet has been researched for its therapeutic applications in a variety of neurological and psychiatric disorders, including Alzheimer's disease, Parkinson's disease, and most recently, bipolar disorder.
There's a critical need for bigger replication studies and well-designed randomized clinical trials to follow up on these findings," added Dr. Campbell. "Our findings indicate that a ketogenic diet may be a useful adjunctive treatment for bipolar disorder, bringing new promise to patients who have difficulty with standard therapies.
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Soup debate between chicken and tomato may have come to an end, with a dietitian telling us which one is the healthier option. For many Americans, January is the National Soup Month, which means they go back to their comfort and easy to make food like soup. With the surge in flu activity in the US, people are consuming soup to get relief. Amid all this, Vandana Sheth, a plant-based dietitian and a diabetes expert tells Fox News the better option. The California-based dietitian says that both soups could be comforting. However, she points out, the nutrition profiles could vary based on the preparation.
Soup's nutrition profile runs through a spectrum of healthy to fatty and caloric. "Choose versions with no added sugars, minimal saturated fat and lower sodium to keep them healthy. When able, enjoy homemade or minimally processed options with fresh vegetables, lean protein and other fiber-rich options," she said.
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Michelle Routhenstein, a New York-based cardiologist, as reported by Fox News, said a standard serving size of chicken noodle soup, which is around one cup, usually contains somewhere around 100 to 150 calories, with 6 to 10 grams of protein, and 500 to more than 1500 milligrams of sodium.
However, Routhenstein also says that homemade chicken soup could also provide lean protein, B vitamins, and immune supporting zinc. There have been studies that show that chicken soup have eased many from their cold symptoms, like nasal congestion and anti-inflammatory effects. However, not all chicken soups are safe. Commercially prepared soups may have a higher level in sodium, which could have a negative impact on blood pressure.
When buying chicken soup, one should always check labels for its sodium content and ensure it must be under 500 milligrams per servings. Sheth also suggests looking out for added sugars and flavors. Sheth also said if the soup is made with lean chicken, vegetables and has a light broth, it can by more nutrient rich. She also recommends to avoid cream-based broth, which could be higher in saturated fat.
Tomato soups have a completely different nutrition profile. "Per 1 cup serving, you will get 70–150 calories depending on [whether] it's broth-based or cream-based, lycopene and vitamins A and C, which can help support eye health and immunity," Sheth said. The sodium content could be lower than in chicken soup, somewhere between 400 to 900 milligrams, especially in canned versions.
Sheth said that when compared to chicken soup, tomato soup trails on protein scale. While Routhenstein highlighted lycopene, as one of the biggest benefits of tomato soup. It is an antioxidant that "may help with reducing inflammation, heart disease and immune health".
"Lycopene has also been studied for its benefit [in reducing the] risk of prostate cancer. Tomato soup is also rich in vitamin C and potassium, which also protect heart and immune health," she added.
Routhenstein says for her, it is tomato soup, because of antioxidant content. However, when it comes to protein and keeping you full, Sheth says chicken soup is a better option.
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A key ingredient found in a common breakfast food may play an important role in supporting heart health and keeping blood sugar levels steady. Fibre is an essential part of a balanced diet, and the NHS recommends that adults aim for at least 30g of fibre each day. Despite this, many people still fall short of the daily target, often without realising the long-term impact on their health.
Fibre is not a single substance. It exists in two main forms, and each affects the body in a different way. Insoluble fibre does not dissolve during digestion. Instead, it passes through the gut largely unchanged, adding bulk to stools and helping the bowels move regularly. This can lower the risk of constipation and reduce the chances of developing intestinal blockages.
Soluble fibre behaves differently. When it comes into contact with water in the digestive system, it forms a gel-like substance. This slows the digestion and absorption of carbohydrates, helping to prevent sudden rises in blood sugar after meals. Because of this effect, soluble fibre can be particularly useful for people managing blood sugar conditions, including diabetes.
Beta-glucans are a specific type of soluble fibre that have attracted attention for their heart-protective benefits. According to the British Heart Foundation, beta-glucan is naturally present in all porridge oats and wholegrains. A standard 40g serving of porridge oats contains around 2g of beta-glucan, making it an easy addition to a heart-friendly diet.
Research suggests that beta-glucan may help improve blood sugar control over time. Studies have found that consuming up to 3.5g of beta-glucan daily can lower blood sugar levels and support better long-term glucose management in people with type 2 diabetes. A higher intake of beta-glucan has also been linked to a reduced risk of developing type 2 diabetes, likely due to its ability to slow sugar absorption.
Another study has highlighted the connection between regular beta-glucan intake and improved heart health. The findings showed that eating just 3g of beta-glucan each day for eight weeks led to a noticeable reduction in cholesterol levels. High cholesterol is a well-known risk factor for heart disease, so even small daily amounts of beta-glucan may offer meaningful benefits.
Beta-glucan is found in a wide range of natural foods, including:
Including a variety of these foods in meals can help increase fibre intake in a balanced way.
As beta-glucan is a form of fibre, increasing intake too quickly can cause mild digestive discomfort. Some people may experience bloating, wind, or constipation, especially in the early stages. These symptoms can often be reduced by staying physically active and drinking enough fluids throughout the day.
If you are concerned about how fibre affects your body, it is advisable to speak with your GP or a qualified health professional. They can offer guidance tailored to your needs. More information on increasing fibre intake and its health benefits is also available on the NHS website.
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While the World Health Organization recommends 5g or a tablespoon of salt every day, Indians consume more than double, increasing their risk of having a fatal stroke exponentially.
According to EatRightIndia, Indians consume about 11g of salt each day through meals which can significantly increase their risk of high blood pressure, strokes and hypertension.
Hypertension causes over 1.6 million deaths annually, accounting for nearly 18 percent of all fatalities and heavily contributes to deaths caused by heart disease, stroke and kidney disease.
The most important side effect of consuming excessive salt intake is high blood pressure. Salt causes the body to retain water, increasing the volume of blood in your vessels and leading to elevated pressure levels. If your blood pressure consistently measures over 140/90 mmHg, it's time to evaluate your salt consumption.
Over time, this can rapidly raise your risk for heart disease, stroke while also potentially contributing to stomach cancer and weakened bones. Additionally, high blood pressure damages kidneys and excess sodium can lead to kidney stones or disease.
Apart from a 5gm recommendation for adults, NHS suggests that children between seven to 11 years of age should not eat more than 5g of salt while those between four to six years of age should eat less than 3g of salt every day to maintain heart health.
Both excessive and insufficient salt intake have been linked to adverse outcomes. Achieving the right balance is critical, and the best approach is to minimize processed food consumption rather than relying solely on the salt shaker.
Common items such as pickles, paapads, chutneys, salads and buttermilk significantly contribute to daily salt consumption. Hidden salts in packaged goods like biscuits, sauces, condiments and snacks also can increase your salt intake.
To cut down on your salt intake, experts recommend:
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