A revolutionary study published in BJPsych Open has revealed compelling evidence that a ketogenic diet can have a major impact on mental and physical well-being in bipolar disorder patients. The study, conducted by Dr. Iain Campbell, PhD, Baszucki Metabolic Psychiatry Research Fellow at the University of Edinburgh, investigates how a metabolic-based intervention might represent an exciting new strategy for treating this serious mental illness.

The research is the first in Europe to use neuroimaging methods, namely magnetic resonance spectroscopy (MRS), to investigate changes in brain metabolism in people with bipolar disorder after a ketogenic diet. The imaging findings revealed decreases in excitatory neurotransmitters, which are normally increased in bipolar disorder. This indicates that the ketogenic diet can stabilize brain activity, possibly reducing mood swings and other symptoms of the condition.

The trial involved 27 participants diagnosed with bipolar disorder, 20 of whom successfully completed the 6-8 week program. A staggering 91% of these individuals maintained ketosis, the metabolic state where the body primarily burns fat for energy instead of carbohydrates. Those who provided consistent daily ketone and mental health assessments reported notable improvements in mood, energy levels, anxiety, and impulsivity.

Dr. Campbell, who personally adheres to a ketogenic diet himself in order to treat symptoms of bipolar disorder, discussed the importance of these results:

"We saw indicators of diminished excitotoxicity in the brain regions most implicated in bipolar disorder. These findings are consistent with the metabolic overdrive hypothesis that postulates energy dysregulation within the brain as central to the disorder. Treating the dysregulation by means of a ketogenic diet could be a game-changer in treatment-resistant patients.

Aside from the scientific evidence, personal accounts of study participants underscore the life-altering effect of a ketogenic diet.

"Quite literally, for the first time in years, I felt like my brain was finally fueled correctly," explained a participant.

Another participant called the diet "a lifeline, restoring my energy and sense of hope. I felt like I was finally healing my mind, not just coping with my bipolar symptoms."

One of the very vivid accounts described the impact of ketosis in terms of a relaxing mental atmosphere:

"Applying a ketogenic diet is akin to giving my mind a nice warm bath. The edginess disappears. I am more calm, more clear, and my brain function is restored again."

Aside from the psychological benefits of the study, the ketogenic diet was also seen to have beneficial effects on participants' physical health. Nineteen out of the 20 trial completers lost a total of 9.3 pounds (4.2 kg) on average and showed improvements in body mass index (BMI) and blood pressure.

These results are noteworthy in that numerous treatments for bipolar disorder, such as mood stabilizers and antipsychotic medications, have been linked to metabolic side effects of weight gain and risk of cardiovascular disease. In contributing to the reduction of such risks, a ketogenic diet may provide a double dividend for patients with bipolar disorder.

Link Between Metabolism and Bipolar Disorder

Although the ketogenic diet has previously been known largely for its utility in treating epilepsy that is treatment-resistant, it is a somewhat new area to explore in conditions of psychiatry such as in bipolar disorder. It has come to be known that metabolic imbalance is an underlying factor in causing psychiatric disorders as energy production deficiencies have been recognized to contribute towards neural excitability and mood disruption.

One of the important findings of the study is that people with bipolar disorder tend to have sodium levels higher than usual within their cells. Lithium, a standard mood stabilizer, acts partly by reducing these sodium levels. The ketogenic diet seems to do the same thing, offering a metabolic explanation for its beneficial effect on mood stabilization.

What Is a Ketogenic Diet?

The ketogenic diet is a high-fat, low-carb diet that changes the body's main source of energy from glucose to ketones. As carbohydrate consumption is significantly decreased, the liver breaks down fats into ketones, which can be used as a substitute fuel by the brain and body.

First developed in the 1920s as a therapy for epilepsy, the ketogenic diet has been researched for its therapeutic applications in a variety of neurological and psychiatric disorders, including Alzheimer's disease, Parkinson's disease, and most recently, bipolar disorder.

There's a critical need for bigger replication studies and well-designed randomized clinical trials to follow up on these findings," added Dr. Campbell. "Our findings indicate that a ketogenic diet may be a useful adjunctive treatment for bipolar disorder, bringing new promise to patients who have difficulty with standard therapies.

Have you been diagnosed with oral cancer? Wondering if you can have your favourite fruit, mango? Then make sure to consult your doctor before having it. Though mangoes are rich in vitamins and antioxidants, oral cancer patients should consume them carefully, depending on their treatment stage and mouth condition. It is not a good idea for oral cancer patients to eat mangoes in large quantities.

Can oral cancer patients eat mangoes?

In an interaction with Health and Me, Dr. Amit Chakraborty, Head and neck onco-surgeon, Mumbai, shared some simple guidelines to help oral cancer patients satisfy their mango cravings healthily.

Everyone, including oral cancer patients, eagerly waits for the mango season. After all, it is difficult to resist mangoes, right? As summer and mangoes go hand in hand, even oral cancer patients may be tempted to eat them. Mangoes are packed with vitamins, antioxidants, and natural sweetness, but they should be eaten in moderation. However, oral cancer patients and those undergoing cancer treatment often wonder whether mangoes are safe for them. Understand that the answer depends on the patient’s condition, stage of treatment, and symptoms affecting the mouth and throat.

What happens when oral cancer patients eat mangoes often?

In many cases, ripe mangoes can be safely consumed by oral cancer patients because they are soft, nutritious, and easy to swallow. However, they should have only two to three small slices of mango per day. It is not advisable to eat an entire mango. Mangoes contain vitamins A, C, and E, along with antioxidants that help support immunity and overall health. They may also provide energy to patients who struggle with appetite loss during treatment. However, oral cancer patients can suffer from mouth ulcers, pain, burning sensations, dry mouth, difficulty chewing, or sensitivity due to chemotherapy, radiation, or surgery.

In such situations, very sweet, fibrous, or slightly sour mangoes may irritate the mouth and increase discomfort. Sticky mango pulp can also sometimes remain inside the mouth, making oral hygiene important. It is necessary to avoid sour and unripe mangoes. Mango pulp, smoothies, or mashed mango can be chosen by patients who have difficulty swallowing. Again, the expert will decide the quantity. If the expert does not allow it, then it is better not to eat mangoes. Maintaining proper oral hygiene after eating is equally important to prevent infections and irritation.

Conclusion

If you have oral cancer and want to eat a mango, choose a soft, ripe mango. Moderation is key, and maintaining oral hygiene is essential. As every patient’s condition is different, follow your doctor’s advice regarding cancer treatment. All you need to do is to ensure that you do not go overboard with the fruit, as it can do more harm than good if eaten mindlessly, especially with comorbidities.

Many women pay attention to iron, calcium, and vitamin D, but don’t consider iodine. Did you know? Iodine is an essential nutrient that supports thyroid function, hormone balance, and ovulation, making it important for women planning pregnancy or managing fertility issues. It is essential for women to make sure they add iodine-rich foods to their diet to enhance thyroid health and regulate ovulation. Make sure to consult an expert who will tell you what to eat and avoid. Women, take charge of your health right away, and you will surely notice the difference.

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In an interview with Health and Me, Dr Sandeep Talwar, Fertility Specialist, Nova IVF Fertility, East of Kailash, Delhi, said, "The thyroid gland plays a pivotal role when it comes to controlling metabolism, energy levels, hormones, and even reproductive health. When thyroid hormone levels become imbalanced, a large number of women experience signs and symptoms such as irregular periods, difficulty with ovulation, weight changes, fatigue, or fertility problems. You will be surprised to know that one of the key nutrients needed for proper thyroid function is iodine. Yes, you heard that right! However, many women don’t know much about it and fail to include it in their daily diet. So, by adding simple iodine-rich Indian foods to everyday meals, it is possible to improve thyroid and reproductive health. A balanced diet, along with regular medical check-ups, can make a positive difference, especially for women who are planning a pregnancy."

Iodine-Rich Indian Foods For Thyroid Health

These iodine-rich foods will be beneficial for Indians in maintaining thyroid health and supporting ovulation:

1. Curd and milk are commonly available iodine-rich foods in Indian households. They also provide calcium and protein, which support overall health during fertility planning. Try to have a bowl of curd or a glass of milk for healthy thyroid function.
2. Eggs contain iodine, protein, healthy fats, and vitamin D, which support hormonal and reproductive health. Have boiled eggs or egg-based dishes for breakfast. Also, the yolk contains iodine, so eating whole eggs in moderation is fine. Make sure to consult an expert before including them in your diet.
3. Fish such as tuna, sardines, and mackerel are rich in iodine and omega-3 fatty acids, which support thyroid health and hormone balance. People who consume non-vegetarian food can include fish once a week as part of a balanced diet.
4. Green leafy vegetables and dals support hormone health. Spinach, rajma, moong dal, and chana can be included in the diet. Though they may not contain very high iodine levels, they support overall reproductive and thyroid health.
5. Iodised salt helps maintain adequate iodine intake. Be cautious and consume it in moderation, as excess salt can increase blood pressure.

Including iodine-rich foods in daily meals, exercising regularly, and undergoing regular thyroid check-ups help improve reproductive health. On World Thyroid Day, it is advised to follow a balanced and healthy diet that will help you manage disorders while also meeting basic nutrition requirements.

Sugar is bad for health, and we have heard this several times, on loop. But little do people realise that not all forms of sugar are bad for your body - some sugars are naturally occurring and might actually be the sweet treat you need. Fructose, for instance, found in fruits, is not as bad as processed sugar. But it is still important to know when to stop. In an interview with Health and Me, Dr Nimitt Nagda, Consulting Physician, Zynova Shalby Hospital, Mumbai, explained how natural sugar is different from processed sugar.

What is natural sugar?

Natural sugars present in fruits and milk tend to have nutrients and fibre, while processed sugar often adds empty calories that can harm health when consumed excessively. This article helps to explain how natural sugars impact the body differently when compared to processed sugars. Read on to know more about this and make sure to avoid excess processed sugar. So, adhere to healthy eating habits.

Sugar is a part of many foods that are eaten by people on a daily basis. However, not all sugars affect the body in the same way. Natural sugars are present in foods such as fruits, vegetables, and milk, whereas processed or added sugars are found in sweets, soft drinks, packaged snacks, bakery products, and desserts. While both types provide energy, the body handles them differently. It is the need of the hour to understand the difference between the two, as excessive intake of processed sugar is linked to obesity, diabetes, heart disease, and fatty liver disease. So, be cautious when it comes to your well-being.

Is natural sugar better?

Natural sugars are usually accompanied by fibre, vitamins, minerals, antioxidants, and water content. Fruits contain fructose, but they also provide fibre that slows down sugar absorption into the bloodstream. This helps maintain stable energy levels and prevents sudden spikes in blood sugar. Milk contains lactose along with protein and calcium, making it more nutritionally balanced. When it comes to processed sugar, it is quickly absorbed by the body because it lacks fibre and nutrients. This can lead to rapid increases in blood sugar and insulin levels. Frequent consumption of sugary foods and beverages may increase cravings, weight gain, fatigue, diabetes, obesity, and fatty liver disease. Processed sugar also contributes to inflammation, tooth decay, and unhealthy fat accumulation in the body. Moreover, natural foods are more filling, whereas processed sugary foods often encourage overeating because they do not satisfy hunger for long.

Natural sugars consumed through whole foods like fruits and milk are generally healthier because they come with essential nutrients and fibre that support overall well-being. Processed sugars, when consumed in excess, can negatively affect health and increase the risk of several chronic diseases. Choosing natural food sources and limiting added sugars can help maintain better energy levels, weight control, and long-term health. So, make sure to pay attention to your health without fail and limit processed sugar.