A revolutionary study published in BJPsych Open has revealed compelling evidence that a ketogenic diet can have a major impact on mental and physical well-being in bipolar disorder patients. The study, conducted by Dr. Iain Campbell, PhD, Baszucki Metabolic Psychiatry Research Fellow at the University of Edinburgh, investigates how a metabolic-based intervention might represent an exciting new strategy for treating this serious mental illness.

The research is the first in Europe to use neuroimaging methods, namely magnetic resonance spectroscopy (MRS), to investigate changes in brain metabolism in people with bipolar disorder after a ketogenic diet. The imaging findings revealed decreases in excitatory neurotransmitters, which are normally increased in bipolar disorder. This indicates that the ketogenic diet can stabilize brain activity, possibly reducing mood swings and other symptoms of the condition.

The trial involved 27 participants diagnosed with bipolar disorder, 20 of whom successfully completed the 6-8 week program. A staggering 91% of these individuals maintained ketosis, the metabolic state where the body primarily burns fat for energy instead of carbohydrates. Those who provided consistent daily ketone and mental health assessments reported notable improvements in mood, energy levels, anxiety, and impulsivity.

Dr. Campbell, who personally adheres to a ketogenic diet himself in order to treat symptoms of bipolar disorder, discussed the importance of these results:

"We saw indicators of diminished excitotoxicity in the brain regions most implicated in bipolar disorder. These findings are consistent with the metabolic overdrive hypothesis that postulates energy dysregulation within the brain as central to the disorder. Treating the dysregulation by means of a ketogenic diet could be a game-changer in treatment-resistant patients.

Aside from the scientific evidence, personal accounts of study participants underscore the life-altering effect of a ketogenic diet.

"Quite literally, for the first time in years, I felt like my brain was finally fueled correctly," explained a participant.

Another participant called the diet "a lifeline, restoring my energy and sense of hope. I felt like I was finally healing my mind, not just coping with my bipolar symptoms."

One of the very vivid accounts described the impact of ketosis in terms of a relaxing mental atmosphere:

"Applying a ketogenic diet is akin to giving my mind a nice warm bath. The edginess disappears. I am more calm, more clear, and my brain function is restored again."

Aside from the psychological benefits of the study, the ketogenic diet was also seen to have beneficial effects on participants' physical health. Nineteen out of the 20 trial completers lost a total of 9.3 pounds (4.2 kg) on average and showed improvements in body mass index (BMI) and blood pressure.

These results are noteworthy in that numerous treatments for bipolar disorder, such as mood stabilizers and antipsychotic medications, have been linked to metabolic side effects of weight gain and risk of cardiovascular disease. In contributing to the reduction of such risks, a ketogenic diet may provide a double dividend for patients with bipolar disorder.

Link Between Metabolism and Bipolar Disorder

Although the ketogenic diet has previously been known largely for its utility in treating epilepsy that is treatment-resistant, it is a somewhat new area to explore in conditions of psychiatry such as in bipolar disorder. It has come to be known that metabolic imbalance is an underlying factor in causing psychiatric disorders as energy production deficiencies have been recognized to contribute towards neural excitability and mood disruption.

One of the important findings of the study is that people with bipolar disorder tend to have sodium levels higher than usual within their cells. Lithium, a standard mood stabilizer, acts partly by reducing these sodium levels. The ketogenic diet seems to do the same thing, offering a metabolic explanation for its beneficial effect on mood stabilization.

What Is a Ketogenic Diet?

The ketogenic diet is a high-fat, low-carb diet that changes the body's main source of energy from glucose to ketones. As carbohydrate consumption is significantly decreased, the liver breaks down fats into ketones, which can be used as a substitute fuel by the brain and body.

First developed in the 1920s as a therapy for epilepsy, the ketogenic diet has been researched for its therapeutic applications in a variety of neurological and psychiatric disorders, including Alzheimer's disease, Parkinson's disease, and most recently, bipolar disorder.

There's a critical need for bigger replication studies and well-designed randomized clinical trials to follow up on these findings," added Dr. Campbell. "Our findings indicate that a ketogenic diet may be a useful adjunctive treatment for bipolar disorder, bringing new promise to patients who have difficulty with standard therapies.

Long-term diet and obesity are known to affect inflammation. A new study from the University of California, San Francisco suggests that even a few days of eating differently can change how strongly the immune system reacts, at least in mice.

What the researchers did

The study was published in Nature on October 28. It was led by Sagar Bapat, a professor of pathology at UCSF and the paper’s corresponding author. Zewen “Owen” Jiang, who did the work as a graduate student at UCSF, was co-first author, according to UCSF.

The team raised mice on either low-fat or high-fat food pellets. They then applied imiquimod, a cream that triggers skin inflammation, to one ear of each mouse. Mice raised on high-fat food and made obese had severe reactions, while mice on low-fat food had mild ones.

Is it the weight or the diet?

Obesity has long been tied to more severe inflammation, but it wasn’t clear why. “We wanted to know whether it was the extra weight or simply the bad diet that was driving the stronger response,” Jiang said.

To find out, the researchers switched normal-weight mice from low-fat to high-fat food for just four days, then applied the cream three days later. These lean mice developed severe ear inflammation, just like the obese mice. In the other direction, obese mice moved to normal food for four days had much milder inflammation.

The paper’s conclusion is that the dietary state around the time inflammation starts, rather than obesity itself, determines how severe the disease gets.

The skin remembered

Weeks later, the normal-weight mice were back on low-fat food and their inflammation had cleared. The researchers applied the cream again to the same ear. The reaction was far stronger than expected.

The researchers found that high-fat food drew rapid-response immune cells into the skin, which amplified the reaction. As the inflammation faded, memory T cells stayed behind in the ear. Together, these changes left the tissue primed for the next flare-up, UCSF reported. The paper also found that the response depends on CD4+ T cells, and that a protein complex called NLRP3 drives the diet-amplified disease.

The team saw a similar heightened response in the lungs after a few days on a high-fat diet.

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What the scientists said

“Long-term dietary habits absolutely matter for health, but our study unearthed a much more real-time influence of diet,” Bapat said. “Breakfast, lunch, dinner, they all can have a tremendous and rapid impact on the immune system.”

Jiang added a note of caution. “The diet of a laboratory mouse doesn’t map neatly onto what we eat, but it’s striking how quickly the immune system responds to what’s happening in the body right now,” he said. “Diet, exercise, sleep, they could all shape immune health in ways we don’t yet appreciate.”

What this does and doesn’t mean

This was a study in mice, and the high-fat pellets used in the lab are not the same as human meals. The findings don’t show that a single unhealthy meal will worsen a person’s skin or lung conditions. They do suggest that what is eaten around the time inflammation begins may matter more than researchers had assumed, and that the immune system may hold a memory of it.

An international team of 23 nutrition scientists has developed a food pyramid emphasizing plant foods, healthier fats and high-quality carbohydrates, offering an alternative to the Trump administration’s meat-heavy dietary advice.

Published in Advances in Nutrition, the International Food Guide Pyramid synthesizes evidence from more than 250 scientific publications and dietary guidelines from seven countries and regions.

“Despite what people often hear, there’s actually substantial agreement in nutrition science about the foundations of healthy eating,” said Karen Della Corte, a Brigham Young University nutritional scientist who led the team.

What Does The New Food Pyramid Recommend?

The pyramid focuses on three principles:

• Make plant foods the foundation of a healthy diet.

• Choose healthier sources of fat and protein.

• Prioritize carbohydrate quality.

It encourages plant-based proteins such as beans, lentils, nuts and soy, without excluding fish, poultry, eggs or dairy. The guide can also be adapted for vegetarian and vegan diets.

The EAT-Lancet Commission estimates that adopting its proposed plant-forward diet could prevent approximately 15 million premature deaths annually.

Why Carbohydrate Quality Matters

The guide prioritizes whole grains and other high-quality carbohydrates over refined grains and sugary drinks. Carbohydrate quality depends on fiber content, processing, food structure and glycemic index (GI), which measures how carbohydrate-containing foods affect blood glucose.

“For both health and sustainability reasons, carbohydrate-rich foods should provide a substantial share of our energy, so their quality is particularly important,” said Anette Buyken, a professor at Paderborn University in Germany.

Traditional staples such as basmati rice, durum pasta, tortillas, rice noodles and bulgur can fit into a healthy diet, Della Corte said, depending on their glycemic index and preparation.

Plant Proteins And Healthier Fats Take Priority

The pyramid also recommends choosing beans, peas, lentils, fish, poultry or yogurt more often than red and processed meats. It also advises replacing saturated fats, such as butter and animal fats, with unsaturated fats from sources such as olive and canola oils.

Other suggestions include choosing nuts, seeds, fruit or vegetables with hummus instead of processed snacks, whole-grain bread over refined white bread, and water instead of sugary soda.

How Does It Differ From Trump’s Dietary Advice?

The international pyramid contrasts with the Trump administration’s updated US dietary guidance, shaped by Health Secretary Robert F. Kennedy Jr.’s “Make America Healthy Again” (MAHA) agenda, which has emphasized meat and other animal-based foods.

Rather than prioritizing red meat, the international guide stresses plant proteins, unsaturated oils and higher-quality carbohydrates. It also considers the environmental impact of food production, including greenhouse gas emissions associated with livestock farming.

“Our diet has to be not only for our own health but also for the health of our planet,” said David Jenkins, a University of Toronto professor and creator of the glycemic index.

The guide also highlights the importance of limiting added sugars, particularly from sugary drinks, and favors water or sugar-free alternatives.

Can The Pyramid Work Across Cultures?

Working with the International Carbohydrate Quality Consortium, Della Corte compared dietary guidelines from Canada, Germany, Australia, China, the Netherlands, the United States and the Nordic countries. She also reviewed more than 250 scientific publications and drew on the EAT-Lancet Planetary Health Diet to identify shared principles of healthy eating.

The researchers say healthy eating does not require everyone to follow the same menu. Recommendations can be adapted to local food traditions, availability and budgets.

“When you’re designing a meal, start by thinking about the plant foods you want to emphasize,” Della Corte said. “What vegetables, whole or lower-GI grains, beans or lentils could you include?”

However, affordability and access can make healthier choices difficult.

“We need food environments that make it easy to put the pyramid’s recommendations into practice,” Buyken said, calling for nutrition policies that address food marketing, access and prices.

Children who consume more ultra-processed foods may show stronger brain responses that could make them crave those foods repeatedly. This helps explain the link between these foods and childhood weight gain, according to a new study.

The research, published in JAMA Network Open, found that kids who ate more ultra-processed foods had greater activity in a brain region that is involved in reward and motivation when they saw tempting pictures of appetising foods. That brain activity was also associated with increase in body fat over the following year.

The findings raise important questions about how eating highly processed foods frequently may affect a developing brain.

UPFs May Influence A Developing Brain

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The study included 46 children aged 7 to 10 who had a healthy weight at the beginning of the research. Scientists collected data about their diets and used functional magnetic resonance imaging (fMRI) to examine brain activity while the children viewed pictures of appetising foods, including cookies and French fries.

The researchers focused on the striatum, a brain region involved in learning, motivation and reward anticipation.

Children who consumed more ultra-processed foods showed stronger responses in the dorsal striatum when viewing food images. Greater activity in this region was also linked with an increase in body mass index (BMI) and body fat percentage one year later.

The researchers found that accounting for differences in brain responses weakened the association between ultra-processed food intake and subsequent increases in BMI by 31% and body fat percentage by 44%. This suggests that brain activity related to reward may help explain part of the relationship.

Senior study author Dr Kathleen A. Page, a professor of medicine and pediatrics at the Keck School of Medicine of the University of Southern California, said, “This study goes beyond just understanding that UPFs affect weight gain. It actually gives us insight into the neurobiological underpinnings by which these foods may be linked to body composition over time.”

Importance Of Childhood Nutrition

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Ultra-processed foods include many packaged snacks, sugary cereals, sweetened drinks, instant meals and other similar products. They are often designed to be convenient, appealing, and have a long shelf life.

The researchers say childhood is an important period for understanding how food habits influence eating patterns and long-term health.

“Children’s brains are still developing, habits are still forming and food preferences are still being made. It’s an important period where the brain is very sensitive to food and the food environment,” Page said.

The research had key limitations. It involved only 46 children, assessed brain activity at a single time point and followed changes in body composition for one year. The observational design means researchers cannot determine whether greater ultra-processed food consumption caused the brain responses or whether other factors contributed to both.

Message For Parents

The findings point to existing concerns about children's diets high in ultra-processed foods. Page emphasised the importance of making healthier options more accessible.

“Changing the food environment to help people access healthier, more minimally processed foods is an important part of the solution,” she said.

Families can offer more fruits, vegetables, whole grains, pulses and other minimally processed foods while limiting consumption of sugary drinks and packaged snacks.