A revolutionary study published in BJPsych Open has revealed compelling evidence that a ketogenic diet can have a major impact on mental and physical well-being in bipolar disorder patients. The study, conducted by Dr. Iain Campbell, PhD, Baszucki Metabolic Psychiatry Research Fellow at the University of Edinburgh, investigates how a metabolic-based intervention might represent an exciting new strategy for treating this serious mental illness.

The research is the first in Europe to use neuroimaging methods, namely magnetic resonance spectroscopy (MRS), to investigate changes in brain metabolism in people with bipolar disorder after a ketogenic diet. The imaging findings revealed decreases in excitatory neurotransmitters, which are normally increased in bipolar disorder. This indicates that the ketogenic diet can stabilize brain activity, possibly reducing mood swings and other symptoms of the condition.

The trial involved 27 participants diagnosed with bipolar disorder, 20 of whom successfully completed the 6-8 week program. A staggering 91% of these individuals maintained ketosis, the metabolic state where the body primarily burns fat for energy instead of carbohydrates. Those who provided consistent daily ketone and mental health assessments reported notable improvements in mood, energy levels, anxiety, and impulsivity.

Dr. Campbell, who personally adheres to a ketogenic diet himself in order to treat symptoms of bipolar disorder, discussed the importance of these results:

"We saw indicators of diminished excitotoxicity in the brain regions most implicated in bipolar disorder. These findings are consistent with the metabolic overdrive hypothesis that postulates energy dysregulation within the brain as central to the disorder. Treating the dysregulation by means of a ketogenic diet could be a game-changer in treatment-resistant patients.

Aside from the scientific evidence, personal accounts of study participants underscore the life-altering effect of a ketogenic diet.

"Quite literally, for the first time in years, I felt like my brain was finally fueled correctly," explained a participant.

Another participant called the diet "a lifeline, restoring my energy and sense of hope. I felt like I was finally healing my mind, not just coping with my bipolar symptoms."

One of the very vivid accounts described the impact of ketosis in terms of a relaxing mental atmosphere:

"Applying a ketogenic diet is akin to giving my mind a nice warm bath. The edginess disappears. I am more calm, more clear, and my brain function is restored again."

Aside from the psychological benefits of the study, the ketogenic diet was also seen to have beneficial effects on participants' physical health. Nineteen out of the 20 trial completers lost a total of 9.3 pounds (4.2 kg) on average and showed improvements in body mass index (BMI) and blood pressure.

These results are noteworthy in that numerous treatments for bipolar disorder, such as mood stabilizers and antipsychotic medications, have been linked to metabolic side effects of weight gain and risk of cardiovascular disease. In contributing to the reduction of such risks, a ketogenic diet may provide a double dividend for patients with bipolar disorder.

Link Between Metabolism and Bipolar Disorder

Although the ketogenic diet has previously been known largely for its utility in treating epilepsy that is treatment-resistant, it is a somewhat new area to explore in conditions of psychiatry such as in bipolar disorder. It has come to be known that metabolic imbalance is an underlying factor in causing psychiatric disorders as energy production deficiencies have been recognized to contribute towards neural excitability and mood disruption.

One of the important findings of the study is that people with bipolar disorder tend to have sodium levels higher than usual within their cells. Lithium, a standard mood stabilizer, acts partly by reducing these sodium levels. The ketogenic diet seems to do the same thing, offering a metabolic explanation for its beneficial effect on mood stabilization.

What Is a Ketogenic Diet?

The ketogenic diet is a high-fat, low-carb diet that changes the body's main source of energy from glucose to ketones. As carbohydrate consumption is significantly decreased, the liver breaks down fats into ketones, which can be used as a substitute fuel by the brain and body.

First developed in the 1920s as a therapy for epilepsy, the ketogenic diet has been researched for its therapeutic applications in a variety of neurological and psychiatric disorders, including Alzheimer's disease, Parkinson's disease, and most recently, bipolar disorder.

There's a critical need for bigger replication studies and well-designed randomized clinical trials to follow up on these findings," added Dr. Campbell. "Our findings indicate that a ketogenic diet may be a useful adjunctive treatment for bipolar disorder, bringing new promise to patients who have difficulty with standard therapies.

Food choices play an important role in overall health, and reproductive health is no exception. Eating junk or highly processed foods occasionally is unlikely to directly cause infertility. However, regularly consuming foods that are high in added sugar, unhealthy fats, salt and refined carbohydrates, while being low in essential nutrients, may affect the body in several ways.

Poor dietary patterns can contribute to weight gain, insulin resistance, inflammation and hormonal changes, all of which may influence fertility. Both men and women can be affected, although the impact may differ depending on individual health, age and other factors.

The Link Between Diet, Weight And Hormonal Health

It can affect healthy body weight: Regular intake of calorie-dense foods such as fried snacks, fast food, sugary beverages and packaged foods can contribute to weight gain. Being significantly overweight or underweight can affect reproductive hormones. In women, excess weight may interfere with ovulation and menstrual regularity, while in men it may affect testosterone levels and sperm production.

It may influence blood sugar and insulin: A diet high in refined carbohydrates and added sugars can contribute to insulin resistance, particularly when combined with excess weight and low physical activity. Insulin resistance can worsen hormonal imbalance and may contribute to irregular ovulation in women, especially those with conditions such as PMOS (earlier known as PCOS).

Nutrient deficiencies can matter: Highly processed foods may provide calories without supplying enough important nutrients. Fertility and reproductive health require adequate amounts of proteins, healthy fats, vitamins and minerals such as folate, iron, zinc, selenium and vitamin D. A diet lacking variety may therefore not provide the nutritional support needed for healthy reproductive function.

Also read: For The First Time, Study Links 'One Sugary Drink A Day' To Higher Stomach Cancer Risk

Why Sperm Health And Overall Diet Matter Too

Sperm health can also be affected: In men, a consistently poor-quality diet may be associated with poorer sperm concentration, movement and quality. Diets rich in fruits, vegetables, whole grains, nuts, seeds, legumes, fish and other nutrient-rich foods are generally considered more supportive of reproductive health.

Inflammation and oxidative stress may play a role: Frequent consumption of highly processed foods, particularly those rich in unhealthy fats and added sugars, may contribute to inflammation and oxidative stress. These processes can affect overall health and may potentially influence egg and sperm quality.

Also read: Can What You Eat Before 9 AM Shape Your Blood Sugar For The Rest Of The Day?

Small Dietary Changes Can Support Reproductive Health

Small changes can make a difference: Improving fertility-supportive nutrition does not mean completely avoiding favourite foods. The focus should be on balance. Fresh fruits and vegetables, whole grains, pulses, nuts, seeds, dairy or suitable alternatives and adequate protein should form a regular part of the diet. Processed snacks, sugary drinks and deep-fried foods can be limited rather than consumed frequently.

Lifestyle matters along with diet: Diet is only one part of fertility. Regular physical activity, adequate sleep, stress management, avoiding smoking and excessive alcohol, and maintaining a healthy weight are also important. Existing conditions such as diabetes, thyroid disorders, or PMOS (earlier known as PCOS) should be properly managed.

Regular consumption of junk and highly processed foods does not automatically mean that a person will become infertile. However, when such foods form a large part of the daily diet, they may contribute to obesity, metabolic problems, nutritional deficiencies and hormonal changes that can affect reproductive health.

A balanced and nutrient-rich diet, combined with healthy lifestyle habits and timely management of medical conditions, can help create a healthier environment for fertility. If a couple is having difficulty conceiving, dietary changes should not replace a proper medical evaluation.

Drinking a sugary beverage every day may be linked to a significantly higher risk of stomach cancer, according to a new study that researchers described as the first of its kind.

The study found that people who consumed at least one sugar-sweetened beverage everyday had 2.45 times the risk of developing gastric cancer compared with those who consumed fewer drinks in a month.

The findings were based on data obtained from 112,284 participants enrolled in the Nurses' Health Study and Health Professionals Follow-Up Study. Over the follow-up period, 278 participants developed gastric cancer.

Researchers from Mass General Brigham Cancer Institute and other institutions published their findings in Gastro Hep Advances.

Daily Sugary Drinks Linked To Higher Stomach Cancer Risk

The researchers examined participants' intake of sugar-sweetened beverages, including regular soft drinks, punch, lemonade and sports drinks.

After accounting for other potential risk factors, people who drank at least one serving of these beverages every day had a 2.45-fold higher risk of gastric cancer than those who consumed them less than once a month.

The association was even stronger among women in the Nurses' Health Study. Women who consumed more than one sugary drink a day had a 3.04-fold higher risk of stomach cancer compared with women who rarely consumed them. The study did not find a similar association between artificially sweetened beverages and gastric cancer.

Also read: How Brachytherapy Is Personalising Radiation Therapy For Breast Cancer

Researchers Think Sugar And Fructose Are Possible Factors

The researchers also looked at participants' intake of fructose, a type of sugar commonly found in sweetened beverages. Higher fructose consumption was associated with a greater incidence of gastric cancer, although the study could not establish exactly why.

Excessive sugar consumption can contribute to several metabolic changes, including weight gain and inflammation, which are being investigated as possible pathways connecting sugary drinks with cancer. However, the researchers stressed that the biological mechanism behind the association is still not established.

Senior author Andrew T. Chan, a gastroenterologist and epidemiologist at Mass General Brigham, said the study addresses an area that has received relatively little attention.

“This is the first study to demonstrate an association between sugar-sweetened beverage intake and gastric cancer in a U.S. population.” Chan noted that stomach cancer remains a major global health burden and is the fifth leading cause of cancer death worldwide.

Also read: Moderna and Merck’s Custom-Made mRNA Cancer Vaccine Shows Promise In Late-Stage Melanoma Trial

H. Pylori Infection Maybe A Common Denominator

The researchers also considered Helicobacter pylori, or H. pylori, a bacterium and one of the most common risk factors for stomach cancer. Among a smaller group of 940 participants for whom information about H. pylori was available, more than one-third showed evidence of infection. However, researchers did not find a clear relationship between sugary-drink consumption and H. pylori infection.

This suggests that the association between sugary beverages and stomach cancer may not simply be explained by sugary drinks increasing the likelihood of H. pylori infection. More research is needed to understand the connection.

Study Does Not Prove Sugary Drinks Cause Cancer

The study was observational, meaning it identified an association but could not establish that consuming sugary drinks directly causes stomach cancer.

Researchers also pointed to several limitations, including limited information about H. pylori infection and family history of stomach cancer. Most participants were also white, which could limit how broadly the findings can be applied to other populations.

Many people think that controlling blood sugar is just about avoiding sugary foods or cutting back on carbohydrates. Sure, what you eat is important but so is when you eat, especially if you have diabetes, prediabetes or insulin resistance.

Why Morning May Be A Better Time To Eat

Your body has an internal clock called the circadian rhythm. And, this impacts your sleep, digestion, hormone release and how your body metabolises energy. The stomach, intestine, liver, pancreas, muscles and fat tissue all work in coordination with this rhythm. In simple terms, the body is generally more prepared to digest and use food during the earlier part of the day.

Hormones also follow a daily pattern. Cortisol, for instance, is naturally more active in the morning, while growth hormone has greater activity at night and in the early hours of the day. Since the body is metabolically more active in the morning, it is often able to handle glucose and protein more efficiently at this time.

This is why having a balanced breakfast at a reasonable time, preferably before 9 am where possible, can be helpful for glycaemic control. It does not mean that breakfast has to be large or heavy. It means that the first meal of the day should be nutritious and should not be delayed unnecessarily.

Also read: Why Sustainable Weight Loss Requires More Than Cutting Calories?

How Skipping Breakfast Can Affect Blood Sugar

Eating early also prevents the long gap without food that can lead to tiredness, excessive hunger and overeating later in the day. By not eating breakfast, a person may be starving by lunchtime and may eat larger portions or foods high in refined carbohydrates. It can cause larger fluctuations in blood sugar.

Those with diabetes who are on insulin or other glucose-lowering medications in particular should eat regular meals. Skipping or delaying food can sometimes lead to hypoglycaemia, or low blood sugar. So, this may cause sweating, shakiness, dizziness, weakness or sudden hunger. In response, a person may overeat, which can then lead to a sharp rise in blood sugar and make overall control more difficult.

Also read: Study Links Lower Protein Intake To Healthy Ageing; Expert Explains Who Should & Shouldn't Cut Back

Should Dinner Be Your Lightest Meal?

The old saying, “Eat breakfast like a king, lunch like a prince and dinner like a pauper,” still has relevance. It does not mean overeating at breakfast. Rather, it reminds us not to make dinner the heaviest meal of the day, especially when it is eaten late.

A good breakfast can include protein, fibre and a moderate amount of carbohydrates. Eggs, curd, paneer, dal, sprouts, vegetables, nuts and whole grains are practical options. Timely eating, along with balanced meals, regular activity, prescribed medicines and medical follow up, can go a long way in improving blood sugar control.