A revolutionary study published in BJPsych Open has revealed compelling evidence that a ketogenic diet can have a major impact on mental and physical well-being in bipolar disorder patients. The study, conducted by Dr. Iain Campbell, PhD, Baszucki Metabolic Psychiatry Research Fellow at the University of Edinburgh, investigates how a metabolic-based intervention might represent an exciting new strategy for treating this serious mental illness.
The research is the first in Europe to use neuroimaging methods, namely magnetic resonance spectroscopy (MRS), to investigate changes in brain metabolism in people with bipolar disorder after a ketogenic diet. The imaging findings revealed decreases in excitatory neurotransmitters, which are normally increased in bipolar disorder. This indicates that the ketogenic diet can stabilize brain activity, possibly reducing mood swings and other symptoms of the condition.
The trial involved 27 participants diagnosed with bipolar disorder, 20 of whom successfully completed the 6-8 week program. A staggering 91% of these individuals maintained ketosis, the metabolic state where the body primarily burns fat for energy instead of carbohydrates. Those who provided consistent daily ketone and mental health assessments reported notable improvements in mood, energy levels, anxiety, and impulsivity.
Dr. Campbell, who personally adheres to a ketogenic diet himself in order to treat symptoms of bipolar disorder, discussed the importance of these results:
"We saw indicators of diminished excitotoxicity in the brain regions most implicated in bipolar disorder. These findings are consistent with the metabolic overdrive hypothesis that postulates energy dysregulation within the brain as central to the disorder. Treating the dysregulation by means of a ketogenic diet could be a game-changer in treatment-resistant patients.
Aside from the scientific evidence, personal accounts of study participants underscore the life-altering effect of a ketogenic diet.
"Quite literally, for the first time in years, I felt like my brain was finally fueled correctly," explained a participant.
Another participant called the diet "a lifeline, restoring my energy and sense of hope. I felt like I was finally healing my mind, not just coping with my bipolar symptoms."
One of the very vivid accounts described the impact of ketosis in terms of a relaxing mental atmosphere:
"Applying a ketogenic diet is akin to giving my mind a nice warm bath. The edginess disappears. I am more calm, more clear, and my brain function is restored again."
Aside from the psychological benefits of the study, the ketogenic diet was also seen to have beneficial effects on participants' physical health. Nineteen out of the 20 trial completers lost a total of 9.3 pounds (4.2 kg) on average and showed improvements in body mass index (BMI) and blood pressure.
These results are noteworthy in that numerous treatments for bipolar disorder, such as mood stabilizers and antipsychotic medications, have been linked to metabolic side effects of weight gain and risk of cardiovascular disease. In contributing to the reduction of such risks, a ketogenic diet may provide a double dividend for patients with bipolar disorder.
Although the ketogenic diet has previously been known largely for its utility in treating epilepsy that is treatment-resistant, it is a somewhat new area to explore in conditions of psychiatry such as in bipolar disorder. It has come to be known that metabolic imbalance is an underlying factor in causing psychiatric disorders as energy production deficiencies have been recognized to contribute towards neural excitability and mood disruption.
One of the important findings of the study is that people with bipolar disorder tend to have sodium levels higher than usual within their cells. Lithium, a standard mood stabilizer, acts partly by reducing these sodium levels. The ketogenic diet seems to do the same thing, offering a metabolic explanation for its beneficial effect on mood stabilization.
The ketogenic diet is a high-fat, low-carb diet that changes the body's main source of energy from glucose to ketones. As carbohydrate consumption is significantly decreased, the liver breaks down fats into ketones, which can be used as a substitute fuel by the brain and body.
First developed in the 1920s as a therapy for epilepsy, the ketogenic diet has been researched for its therapeutic applications in a variety of neurological and psychiatric disorders, including Alzheimer's disease, Parkinson's disease, and most recently, bipolar disorder.
There's a critical need for bigger replication studies and well-designed randomized clinical trials to follow up on these findings," added Dr. Campbell. "Our findings indicate that a ketogenic diet may be a useful adjunctive treatment for bipolar disorder, bringing new promise to patients who have difficulty with standard therapies.
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Been wondering if your child has been consuming too much or too little water each day?
According to Dr Keerti Kulkarni, a Telangana-based pediatrician, toddlers should be consuming about 100ml per kg of water every day, school children should drink up to 90ml per kg and teenagers should take in up to 60ml per kg.
In a lengthy Instagram post, she noted that about 20 percent of their daily required water intake comes from food includng fruits, vegetables, soups and parents should be mindful not to provide children with excess water.
Dr Kulkarani also said that there are exceptions for underweight children who have any other medical issues, such as kidney problems or if they are on any regular medication.
The expert warned: "Breastfed or formula-fed babies do not need extra water before solid foods and giving extra water to young infants can be dangerous and may cause low sodium levels."
Dehydration occurs when the body loses more fluids than it takes in, impairing normal function. In children, signs include:
Drinking excessive water can lead to water intoxication, causing symptoms like confusion, nausea, and seizures; severe cases may be fatal. Water intoxication, also termed hyperhydration, water poisoning or water toxaemia, develops when an individual drinks much more water than the kidneys can excrete.
The main function of the kidneys in the human body is the processing and excretion of excess water. However, the human kidneys can process only up to 0.8 to 1.0L of water at a time. Drinking an amount that exceeds this may overwhelm the kidneys and put the electrolyte balance out of sync in the human body.
Electrolytes, especially sodium, are essential in maintaining fluid balance within and outside cells. Hyponatremia is a condition in which sodium levels fall below 135 mmol/L, resulting from excessive water intake. This causes water to shift into cells, swelling them. In the brain, this can cause severe complications, including coma or even death.
Symptoms of water intoxication vary from mild to severe. Early symptoms are often similar to dehydration, which makes self-diagnosis challenging. Common symptoms include:
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Eating omega-3-rich foods can reduce your aggression levels by 28 percent, an Aggression and Violent Behavior study suggests.
After analyzing 29 randomized controlled trials involving 3,918 participants in total, researchers from the University of Pennsylvania concluded that the fish oil supplement can reduce both reactive anger (in response to provocation) and proactive anger (behavior planned in advance) in people regardless of age, gender, medical diagnosis and length and dosage of treatment.
Neurocriminologist Dr Adrian Raine said of the results: "I think the time has come to implement omega-3 supplementation to reduce aggression, irrespective of whether the setting is the community, the clinic, or the criminal justice system.
"At the very least, parents seeking treatment for an aggressive child should know that in addition to any other treatment that their child receives, an extra portion or two of fish each week could also help."
The scientists theorized that omega-3 can reduce brain inflammation and regulate vital brain functioning which helps maintain aggression levels. However, they also noted that further research was needed to understand the link.
"Omega-3 is not a magic bullet that is going to completely solve the problem of violence in society. But can it help? Based on these findings, we firmly believe it can, and we should start to act on the new knowledge we have." Dr Raine said.
These omega-3s play a critical role in human development, and they are primarily found in fatty fish and fish oil. Since many people do not consume enough fish, supplementation is often recommended to ensure adequate intake of these essential fatty acids.
Although the body can convert another type of omega-3, alpha-linolenic acid (ALA), into EPA and DHA, this process is not highly efficient. As a result, fish oil supplements may provide a convenient way to ensure optimal levels of omega-3s.
READ MORE: NHS Doctor Says This Oil Instead of Cod Liver Is The Best Omega-3 Source
Some popular sources of Omega-3 include:
EPA and DHA are essential for maintaining brain function throughout life. These fatty acids are abundant in the brain's cell membranes, helping to preserve cell health and facilitate communication between brain cells.
Research has shown that a lack of omega-3 can lead to cognitive impairments. In animal studies, diets deficient in omega-3s resulted in reduced DHA levels in the brain, leading to deficits in learning and memory. In older adults, lower DHA levels have been linked to a smaller brain size, which may indicate accelerated brain ageing.
Maintaining sufficient levels of omega-3s can help support cognitive function and may reduce the risk of age-related brain decline.
The optimal dosage varies, but research suggests that 1,000–2,000 mg of omega-3 fatty acids from fish oil daily is a good starting point. People with depression should look for supplements with higher EPA content. It is pertinent to note that people should consult health experts before starting fish oil supplementation.
Earlier this month, Finance Minister Nirmala Sitharaman announced a surprising tax reduction for India's fishers and marine industry, and experts say it is good news for you too.
Until now, fish caught by Indian vessels beyond territorial waters and brought back to the country for mass consumption has been treated as import, attracting customs duties and integrated goods and services tax (GST).
The combined tax burden raises costs and compliance issues, which discouraged people from deep-sea and exclusive economic zone (EEZ) fishing as well as
However, during her Union Budget 2026 presentation, Sitharaman proposed that fish caught in the EEZ and high seas by Indian fishing vessels are treated as duty-free when brought into Indian ports and treated as exports when landed at foreign ports.
This means that the market availability for Omega-3 packed fishes including salmon, mackerel, tuna, herring and sardines will significantly increase as their existing steep prices see a tremendous fall.
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Bird Flu In India: Amid bird flu fears from Bihar's Bhagalpur district in Naugacha, where over 150 crows were found dead, new concerns are being raised around poultry products. Chennai too is facing a high bird flu alert, there too, dead crows were found. This is why it is important to know how to consume poultry safely and what all to keep in mind while handling poultry.
While there is no confirmation yet in if it has spread in chicken, India has seen previous cases of avian flu in chicken. Here's what you should know about consuming poultry.
Pasteurization and cooking them at high temperatures can curb the threat. It is also important to handle your poultry products when you are buying and storing them.
Also, avoid drinking raw milk to kill avian influenza A(H5N1).
The meat juice can spill over and contaminate other food items, therefore it is extremely important to store it properly, in a way that it does not contaminate another food item. Always store it in a cool bag when you are transporting it and refrigerate and freeze the meat for the first two hours of buying.
You must also cook your chicken so the viruses do not survive on the chicken.
Read: How To Eat Eggs Safely?
Yes, chicken and eggs are still safe to consume, as long as they are thoroughly cooked. Cooking chicken to the internal temperature of at least 165°F kills bacteria, viruses, and other germs, such as H5N1. The most accurate method of assuring that food is cooked is to use a meat thermometer.
Flu viruses can infect chicken eggs by entering through the eggshell. The eggshells are smaller than the pores of eggshells, which means viruses can enter the eggs and the egg's surface will still be protected. However, it is still important to handle it safely.
As per the US Food and Drug Administration, cooking poultry, eggs and other animal products to the proper temperature and preventing cross-contamination between raw and cooked food.
Reject suspect eggs that are small, soft-shelled, or deformed since these may be a sign of infection in hens, though infected birds usually discontinue laying eggs before the situation gets worse.
While pasteurized eggs have a lower risk of infection because pasteurization effectively kills viruses, including bird flu, and bacteria. When cooking eggs, FDA officials advise:
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