A revolutionary study published in BJPsych Open has revealed compelling evidence that a ketogenic diet can have a major impact on mental and physical well-being in bipolar disorder patients. The study, conducted by Dr. Iain Campbell, PhD, Baszucki Metabolic Psychiatry Research Fellow at the University of Edinburgh, investigates how a metabolic-based intervention might represent an exciting new strategy for treating this serious mental illness.

The research is the first in Europe to use neuroimaging methods, namely magnetic resonance spectroscopy (MRS), to investigate changes in brain metabolism in people with bipolar disorder after a ketogenic diet. The imaging findings revealed decreases in excitatory neurotransmitters, which are normally increased in bipolar disorder. This indicates that the ketogenic diet can stabilize brain activity, possibly reducing mood swings and other symptoms of the condition.

The trial involved 27 participants diagnosed with bipolar disorder, 20 of whom successfully completed the 6-8 week program. A staggering 91% of these individuals maintained ketosis, the metabolic state where the body primarily burns fat for energy instead of carbohydrates. Those who provided consistent daily ketone and mental health assessments reported notable improvements in mood, energy levels, anxiety, and impulsivity.

Dr. Campbell, who personally adheres to a ketogenic diet himself in order to treat symptoms of bipolar disorder, discussed the importance of these results:

"We saw indicators of diminished excitotoxicity in the brain regions most implicated in bipolar disorder. These findings are consistent with the metabolic overdrive hypothesis that postulates energy dysregulation within the brain as central to the disorder. Treating the dysregulation by means of a ketogenic diet could be a game-changer in treatment-resistant patients.

Aside from the scientific evidence, personal accounts of study participants underscore the life-altering effect of a ketogenic diet.

"Quite literally, for the first time in years, I felt like my brain was finally fueled correctly," explained a participant.

Another participant called the diet "a lifeline, restoring my energy and sense of hope. I felt like I was finally healing my mind, not just coping with my bipolar symptoms."

One of the very vivid accounts described the impact of ketosis in terms of a relaxing mental atmosphere:

"Applying a ketogenic diet is akin to giving my mind a nice warm bath. The edginess disappears. I am more calm, more clear, and my brain function is restored again."

Aside from the psychological benefits of the study, the ketogenic diet was also seen to have beneficial effects on participants' physical health. Nineteen out of the 20 trial completers lost a total of 9.3 pounds (4.2 kg) on average and showed improvements in body mass index (BMI) and blood pressure.

These results are noteworthy in that numerous treatments for bipolar disorder, such as mood stabilizers and antipsychotic medications, have been linked to metabolic side effects of weight gain and risk of cardiovascular disease. In contributing to the reduction of such risks, a ketogenic diet may provide a double dividend for patients with bipolar disorder.

Link Between Metabolism and Bipolar Disorder

Although the ketogenic diet has previously been known largely for its utility in treating epilepsy that is treatment-resistant, it is a somewhat new area to explore in conditions of psychiatry such as in bipolar disorder. It has come to be known that metabolic imbalance is an underlying factor in causing psychiatric disorders as energy production deficiencies have been recognized to contribute towards neural excitability and mood disruption.

One of the important findings of the study is that people with bipolar disorder tend to have sodium levels higher than usual within their cells. Lithium, a standard mood stabilizer, acts partly by reducing these sodium levels. The ketogenic diet seems to do the same thing, offering a metabolic explanation for its beneficial effect on mood stabilization.

What Is a Ketogenic Diet?

The ketogenic diet is a high-fat, low-carb diet that changes the body's main source of energy from glucose to ketones. As carbohydrate consumption is significantly decreased, the liver breaks down fats into ketones, which can be used as a substitute fuel by the brain and body.

First developed in the 1920s as a therapy for epilepsy, the ketogenic diet has been researched for its therapeutic applications in a variety of neurological and psychiatric disorders, including Alzheimer's disease, Parkinson's disease, and most recently, bipolar disorder.

There's a critical need for bigger replication studies and well-designed randomized clinical trials to follow up on these findings," added Dr. Campbell. "Our findings indicate that a ketogenic diet may be a useful adjunctive treatment for bipolar disorder, bringing new promise to patients who have difficulty with standard therapies.

Americans reach for coffee more often than any other drink, and studies continue to show that a couple of daily cups suit most people and may even support overall health. At the same time, nearly half of U.S. adults live with high blood pressure, defined as a systolic reading above 130 mmHg or a diastolic reading above 80 mmHg.

This raises a natural question. Does caffeine play a part in rising blood pressure levels? Is our strong preference for coffee adding to the problem, or could regular coffee intake possibly help keep blood pressure lower?

Coffee And High Blood Pressure: Is There A Link?

Many people enjoy coffee because it sharpens focus and lifts energy. That same stimulating action is also what can nudge blood pressure upward for a short while. John Higgins, MD, a cardiologist and professor of medicine at UTHealth Houston, agrees that this happens and notes that the general answer is yes. Moderate coffee use is usually acceptable for people whose blood pressure is stable or only slightly raised, though individuals react differently. While caffeine can push readings higher for a brief period, long-term drinking patterns tell another story.

Several studies report no added risk of hypertension among people who drink coffee often. A review of 13 cohort studies found no clear link between coffee intake and the development of high blood pressure. A separate 2023 review even noted that heavier coffee consumption was tied to a 7 percent lower risk of hypertension. The evidence suggests that people who drink coffee regularly tend to build tolerance to caffeine’s short-lived effect on blood pressure.

The 2025 AHA/ACC Hypertension Guideline does not list specific limits for coffee, and the American Heart Association states that moderate amounts appear fine for healthy adults.

How Much Coffee Is Safe To Consume For Blood Pressure Patients?

There is no set rule, but research supports one to three cups a day for most people whose blood pressure is well controlled.

Remember that caffeine levels can vary quite a bit depending on the brewing method, and it is wise to think about your total caffeine intake, including tea, soft drinks, and energy drinks.

Keep the following points in mind when having coffee:

• Choose your add-ins carefully. Sugar, flavored syrups, and full-fat milk can lead to weight gain and metabolic issues, both of which raise blood pressure risk and may add to caffeine’s influence.
• Avoid drinking coffee late in the afternoon. Coffee taken after two or three o’clock can disturb sleep, and poor sleep on its own can worsen blood pressure.
• Allow some time before checking your blood pressure. Coffee can cause a temporary rise, giving you an inaccurate reading. If you want to see how caffeine affects you, measure your pressure before drinking and again 30 to 60 minutes later.

Who Should Avoid Drinking Coffee?

Drinking coffee is generally safe for those with steady or slightly raised blood pressure, and the greater concern usually lies with uncontrolled hypertension. Still, people who are sensitive to caffeine or have poorly managed blood pressure should be more careful.

Extra caution is advised if you have:

• Uncontrolled stage 2 or 3 hypertension
• Organ damage tied to long-standing high blood pressure or other chronic illnesses
• Heart rhythm problems, particularly atrial fibrillation
• Conditions such as hypertrophic cardiomyopathy

In these situations, consider limiting or avoiding caffeinated coffee until your readings improve. Keep in mind that coffee is only one part of overall blood pressure care. Do not overlook reducing sodium intake, staying active, managing weight, and following prescribed treatment.

"ADHD typically is addressed by behavioral changes and therapy, but did you know that the actual treatment for ADHD lies in the food and the nutrition that you consume," is a claim made by Manjari Chandra, a nutritional medicine practitioner. She shares that mood and food are linked. While it is true that science has long revealed that what you eat could impact your mood, but does it mean it can cure a mental health disorder?

The nutritionist pointing out that the "actual treatment for ADHD lies in food" has raised eye brows. While it is true that what you eat impacts your brain health, it cannot simply fix ADHD.

Another is a claim by Be Medic Academy, where they have posted on there Instagram channel that ADHD Can Be Treated Through Diet. The reel says, "In India, 58% of people are suffering from mental and emotional problems like ADHD, GAD, stress, depression, etc., and these can be cured only and only through lifestyle changes and diet."

To dig deeper into the claim, the Health and Me ran a fact check on it.

What Did We Find About The Claim That Your Diet Can Treat ADED?

Dr Miguel Toribio-Mateas, who is a clinical neurologist, and is known for his informational videos on ADHD points out that there is a link between nutrition, ADHD, and other brain health disorders, however, this, alone cannot treat ADHD.

Dr Mateas says that one can tackle the symptoms of ADHD through gut-brain axis. One can increase fibers, inulin, which can be found in red chicory and have food rich in polyphenols. Other components like isoflavone or other antioxidants could "actually go throughout your body and regulate loads of different functions in the body." However, the video notes that diet cannot alone be the cure.

Experts and doctors have pointed out that there is no scientific or medical consensus to back the claim that diet alone can cure ADHD. In fact, a recent study in Current Nutrition Report noted that supplementing the diet with zinc and iron could reduce the severity of ADHD symptoms, however, it did not mean that it can cure ADHD altogether.

Another study led by Olweya Mohammed Abd El Baaki et.al., noted that reduced intake of carbohydrates and proteins was linked to improvements in ADHD symptoms. All studies noted that diet can manage the symptoms, however, it cannot cure the condition on its own.

Dr Rahul Chwala, who is an associate consultant in the Department of Neurology at PSRI Hospitals in New Delhi tells Medical Dialogues, "The claim that ADHD can be treated solely through diet is false. While certain dietary modifications, like reducing processed foods, artificial additives and ensuring balanced nutrition, may support overall brain health and behavior, they do not cure or treat ADHD."

The doctor says that ADHD is a neurodevelopmental disorder with complex genetic and neurological factors. "Evidence based treatments primarily includes behavioral therapy and medications such as stimulants [are used for treatment]. Dietary interventions can complement, but not replace medical management."

Do foods impact our mood and how we feel? For some of us, cake makes us happy, for others, a bowl of salad. But, is there really a connection? For years, we have thought that foods like pizza, a cake, or something that is quick and can be made instantly makes us happy.

But experts argue that this belief is less science and more savvy advertising.

“People are like walking wallets to food companies,” Felice Jacka, Director of the Food and Mood Centre at Deakin University in Australia tells this to NPR. “They sell you this myth that eating these foods will make you feel good.”

In reality, these foods can mimic a short-lived high , a bit like champagne, she says. “Feels good in the short term, but the long-term impact is the opposite.”

How Does Food Shape Your Mood?

Over the past 15 years, Jacka and other researchers have built the field of nutritional psychiatry, exploring how diet influences mood and mental health. Their findings are clear: while some foods lift your mood and protect against depression, others do the exact opposite.

Ultraprocessed foods or UPFs, which packed with refined sugars, white flours and additives, fall firmly in the mood-draining category. People often feel anxious, irritable or lethargic a few hours after eating them.

Speaking to NPR, Dr Kara Margolis, a pediatric gastroenterologist at New York University tells that she sees this link regularly. “Some weekend mornings, I go to a diner and have a waffle. By 10 o’clock, I feel terrible,” she says.

Long-term patterns matter even more. “Large epidemiological studies show a 20% to 30% higher risk of depression when diets are high in ultraprocessed foods and refined carbohydrates,” Margolis adds.

At the same time, several controlled trials reveal that cutting these foods out and replacing them with whole, minimally processed foods helps reduce depression symptoms. The paradox? When people believe ultraprocessed foods make them happy, they tend to eat more of them.

The Gut–Brain Connection

If sugary treats aren’t true “happy foods,” then what is? Scientists are still mapping this connection, but one strong contender keeps emerging: whole grains.

“Whole grains seem to be particularly important,” says Jacka. Their power comes from fermentable fiber, which feeds beneficial gut bacteria. When these microbes digest fiber, they produce molecules that reduce inflammation, improve insulin sensitivity and strengthen gut-brain communication, all factors linked to better mood.

“Making the environment in your gut right for good bacteria not only can affect mood, but it can protect you from nearly every medical condition that’s been studied,” says Margolis, citing heart disease and diabetes among them.

As the holiday season approaches, what are the four ways one can eat food that makes us happy, but for a longer period of time.

Four Ways To Eat For a Happier Holiday Season

Cook at Home More Often

Jacka says there are two independent ways to influence mood through diet, and the first is: cut back on ultraprocessed foods.

That includes foods with artificial sweeteners, refined carbs, preservatives, emulsifiers (like xanthan gum or soy lecithin), and artificial flavors.

During the holidays, skip store-bought pies, pastries and fast-food burgers. Jacka suggests making a “beautiful flour-free cake using almond meal and honey. It’s still sweet, but much better for your mood.”

Make the Holidays Less ‘White’

The second strategy: increase whole grains.

Swap croissants and sugary cereals for oats or brown-rice congee. Choose corn tortillas over flour ones. Switch biscuits and white rolls for 100% whole-wheat versions. Even baking can be tweaked, use oat, barley or whole-wheat flour.

Add Beans and Lentils

Another powerful source of fermentable fiber is legumes.

“Your microbiome loves beans,” says Dr Meroë Morse of MD Anderson Cancer Center, as reported in NPR. Even a small amount, a quarter cup of cooked beans, can deliver a significant fiber boost.

Speaking to NPR, Hannah Holscher, microbiome scientist and dietitian at the University of Illinois Urbana-Champaign, recommends tossing beans or lentils into soups, curries or chili. Lentils cook quickly and are cost-effective, making them an easy daily addition.

Increase Slowly

Beans, lentils and dense whole grains can be intense for an unprepared gut. Holscher advises starting with small servings and increasing gradually. Soaking beans or trying different varieties may also help minimize bloating.

Other fermentable-fiber foods, chia seeds, berries, pears, apples, avocados and even unripe bananas, can round out your fiber intake.