A revolutionary study published in BJPsych Open has revealed compelling evidence that a ketogenic diet can have a major impact on mental and physical well-being in bipolar disorder patients. The study, conducted by Dr. Iain Campbell, PhD, Baszucki Metabolic Psychiatry Research Fellow at the University of Edinburgh, investigates how a metabolic-based intervention might represent an exciting new strategy for treating this serious mental illness.

The research is the first in Europe to use neuroimaging methods, namely magnetic resonance spectroscopy (MRS), to investigate changes in brain metabolism in people with bipolar disorder after a ketogenic diet. The imaging findings revealed decreases in excitatory neurotransmitters, which are normally increased in bipolar disorder. This indicates that the ketogenic diet can stabilize brain activity, possibly reducing mood swings and other symptoms of the condition.

The trial involved 27 participants diagnosed with bipolar disorder, 20 of whom successfully completed the 6-8 week program. A staggering 91% of these individuals maintained ketosis, the metabolic state where the body primarily burns fat for energy instead of carbohydrates. Those who provided consistent daily ketone and mental health assessments reported notable improvements in mood, energy levels, anxiety, and impulsivity.

Dr. Campbell, who personally adheres to a ketogenic diet himself in order to treat symptoms of bipolar disorder, discussed the importance of these results:

"We saw indicators of diminished excitotoxicity in the brain regions most implicated in bipolar disorder. These findings are consistent with the metabolic overdrive hypothesis that postulates energy dysregulation within the brain as central to the disorder. Treating the dysregulation by means of a ketogenic diet could be a game-changer in treatment-resistant patients.

Aside from the scientific evidence, personal accounts of study participants underscore the life-altering effect of a ketogenic diet.

"Quite literally, for the first time in years, I felt like my brain was finally fueled correctly," explained a participant.

Another participant called the diet "a lifeline, restoring my energy and sense of hope. I felt like I was finally healing my mind, not just coping with my bipolar symptoms."

One of the very vivid accounts described the impact of ketosis in terms of a relaxing mental atmosphere:

"Applying a ketogenic diet is akin to giving my mind a nice warm bath. The edginess disappears. I am more calm, more clear, and my brain function is restored again."

Aside from the psychological benefits of the study, the ketogenic diet was also seen to have beneficial effects on participants' physical health. Nineteen out of the 20 trial completers lost a total of 9.3 pounds (4.2 kg) on average and showed improvements in body mass index (BMI) and blood pressure.

These results are noteworthy in that numerous treatments for bipolar disorder, such as mood stabilizers and antipsychotic medications, have been linked to metabolic side effects of weight gain and risk of cardiovascular disease. In contributing to the reduction of such risks, a ketogenic diet may provide a double dividend for patients with bipolar disorder.

Link Between Metabolism and Bipolar Disorder

Although the ketogenic diet has previously been known largely for its utility in treating epilepsy that is treatment-resistant, it is a somewhat new area to explore in conditions of psychiatry such as in bipolar disorder. It has come to be known that metabolic imbalance is an underlying factor in causing psychiatric disorders as energy production deficiencies have been recognized to contribute towards neural excitability and mood disruption.

One of the important findings of the study is that people with bipolar disorder tend to have sodium levels higher than usual within their cells. Lithium, a standard mood stabilizer, acts partly by reducing these sodium levels. The ketogenic diet seems to do the same thing, offering a metabolic explanation for its beneficial effect on mood stabilization.

What Is a Ketogenic Diet?

The ketogenic diet is a high-fat, low-carb diet that changes the body's main source of energy from glucose to ketones. As carbohydrate consumption is significantly decreased, the liver breaks down fats into ketones, which can be used as a substitute fuel by the brain and body.

First developed in the 1920s as a therapy for epilepsy, the ketogenic diet has been researched for its therapeutic applications in a variety of neurological and psychiatric disorders, including Alzheimer's disease, Parkinson's disease, and most recently, bipolar disorder.

There's a critical need for bigger replication studies and well-designed randomized clinical trials to follow up on these findings," added Dr. Campbell. "Our findings indicate that a ketogenic diet may be a useful adjunctive treatment for bipolar disorder, bringing new promise to patients who have difficulty with standard therapies.

Oily and spicy foods are often a highlight of summer parties, but they can also lead to digestive issues, especially in hot weather. During summer, the body’s metabolism tends to slow down slightly as it focuses more on maintaining temperature balance. Heavy, greasy foods like fried snacks or rich curries take longer to digest, putting extra strain on the digestive system. This can result in symptoms such as bloating, heaviness, and discomfort.

Spicy foods, while tasty, can further aggravate the problem. Ingredients like chili peppers increase heat in the body, which may already be elevated due to the hot weather. This excess heat can irritate the stomach lining, leading to acidity, heartburn, or even loose motions in sensitive individuals. People who already have conditions like gastritis or acid reflux are more likely to experience worsening symptoms after consuming spicy dishes.

Dehydration And Food hygiene

Another important factor is dehydration. In summer, the body loses more fluids through sweating. Oily and spicy foods do not provide hydration and may even increase the need for water. If fluid intake is not sufficient, digestion becomes slower and less efficient. This can lead to constipation or a feeling of fullness for a longer time.

Food hygiene at parties also plays a role. Oily foods are often prepared in bulk and kept out for long periods. In hot temperatures, this increases the risk of bacterial growth, which can cause food poisoning, stomach cramps, vomiting, or diarrhea.

Balance Your Plate

To avoid these issues, it is better to balance your plate. Including lighter options like fruits, salad, grilled items, and plenty of water can help maintain digestion. Limiting the intake of deep-fried and overly spicy foods, especially during peak heat hours, can prevent discomfort.

In conclusion, while oily and spicy foods add flavor and enjoyment to summer parties, overconsumption in hot weather can disrupt digestion and lead to multiple gastrointestinal problems. Making mindful food choices helps you enjoy the party without compromising your health.

PCOD is a hormonal disorder common among women of reproductive age. It can cause irregular periods, excess androgen levels (leading to symptoms like acne and hirsutism), and polycystic ovaries. Diet plays a crucial role in managing PCOD symptoms, particularly by addressing insulin resistance, which is common in women with the condition, and reducing inflammation.

Dr S. K. Wangnoo, Senior Consultant, Endocrinology, Indraprastha Apollo Hospital, Delhi, in an interaction with Health and Me, listed the best and worst foods for women dealing with PCOD.

10 Best Foods for PCOD

A PCOD-friendly diet emphasises whole, unprocessed foods that help regulate blood sugar and hormone levels.

1. Whole Grains: Brown rice, quinoa, oats, whole wheat bread, and millets are low glycaemic index carbohydrates that provide sustained energy and fibre.
2. Lean Proteins: Chicken; fish (especially fatty fish like salmon, tuna, and sardines); eggs; and plant-based proteins such as legumes (lentils, chickpeas, and beans) are vital for muscle maintenance and satiety.
3. Healthy Fats: Sources like avocados, olive oil, nuts (almonds, walnuts), and seeds (chia, flax, pumpkin) provide essential fatty acids that reduce inflammation and support hormonal balance.
4. High-Fibre Vegetables: Non-starchy vegetables such as spinach, broccoli, kale, bell peppers, and cucumbers are rich in fibre, vitamins, and antioxidants.
5. Berries: Blueberries, strawberries, raspberries, and other berries are low in sugar and packed with antioxidants.
6. Legumes and Beans: Lentils, chickpeas, and various beans are excellent sources of fibre and plant-based protein, which help manage blood sugar.
7. Nuts: Almonds, walnuts, and other nuts offer healthy fats, fibre, and protein, contributing to a feeling of fullness.
8. Seeds: Chia seeds, flaxseeds, and pumpkin seeds are rich in omega-3 fatty acids and fibre, supporting digestive and hormonal health.
9. Anti-inflammatory Foods: Many of the foods listed above, particularly leafy greens and fatty fish, naturally possess anti-inflammatory properties that can alleviate PCOD symptoms.
10. Unrefined and Natural Foods: Prioritising foods in their whole and natural state, avoiding artificial ingredients and excessive processing, is key for managing PCOD.

10 Worst Foods for PCOD

Dr Wangnoo said that certain foods can worsen PCOD symptoms by contributing to insulin resistance, inflammation, and weight gain.

1. Refined Carbohydrates: White bread, white pasta, pastries, cakes, and sugary cereals cause rapid spikes in blood sugar and insulin levels.
2. Sugary Drinks: Sodas, sweetened fruit juices, and energy drinks are major sources of added sugars, which can exacerbate insulin resistance.
3. Processed Foods: Packaged snacks, fast food, and highly processed meals often contain a detrimental combination of unhealthy fats, sugars, and refined carbohydrates.
4. Fried Foods: Deep-fried items are typically high in unhealthy fats and can contribute to inflammation and weight gain.
5. Unhealthy Fats: Trans fats and excessive saturated fats, found in many processed snacks, red meats, and some dairy products, can increase inflammation.
6. Rich Red Meats: High consumption of fatty red meats may contribute to inflammation and should be limited.
7. High-Fat Dairy Products: While some individuals with PCOD tolerate low-fat dairy, high-fat dairy like certain cheeses and full-fat milk are often advised to be limited due to potential inflammatory effects.
8. Sweetened Desserts: Cakes, cookies, and other sugary desserts are high in refined sugars and unhealthy fats, which are detrimental to PCOD management.
9. Refined Oils: While not explicitly listed as a "food," highly refined vegetable oils (e.g., corn, soybean) can contribute to inflammation and are best limited, favouring olive oil or avocado oil instead.
10. White Rice and Pasta: These refined grains have a higher glycaemic index compared to whole grains and can cause quicker blood sugar spikes.

A fitness enthusiast follows a disciplined routine not just at the gym but in terms of diet as well. For any weight-loss or fitness-centric routine, diet is the most important component, as it makes all the difference. This means you would be eating clean and a limited amount of food to achieve a calorie deficit. Yet, many times, cravings take over. Do not fret—cheat days are not as bad as you may think. In fact, the occasional cheat day does more good than harm if one makes the right choices. In an interview with Health and Me, a nutritionist shared some of the most common cheat day food choices. The expert also ranked them on a scale from one to 10 depending on their nutritional value.

Prachi Mandholia, a Mumbai-based clinical nutritionist, said, “When it comes to ‘cheat day’ indulgences, I always tell my clients that enjoyment is important, but awareness is everything. Not all cheat foods are equally harmful; some can be relatively balanced if consumed mindfully.”

What are the best and worst cheat day food options for your health?

Mandholia listed 10 popular foods that most people love to eat on their cheat day. The expert also ranked the foods based on their nutritional value and their subsequent impact on health.

Steamed Momos: 6/10

A better pick among indulgent options, momos are steamed, which significantly reduces fat content. When filled with vegetables or lean chicken, they offer some nutritional value. However, the outer layer is made of refined flour (maida), which lowers fibre content and can spike blood sugar.

Papdi Chaat: 3/10

While delicious, this dish combines fried papdi, sweet chutneys, and curd, making it high in unhealthy fats and sugars. It lacks balance and can be heavy on digestion.

Gol Gappe (Pani Puri): 4/10

Despite the fried puris, the spiced water can aid digestion, especially when made with ingredients like mint and jeera. Adding sprouts improves protein content, but sweet chutneys reduce its overall score.

Chhole Kulche: 5/10

Chhole provides plant-based protein and fibre, but kulche made from refined flour make this dish less wholesome. Portion control is key here.

Pepperoni Pizza: 2/10

This is a highly inflammatory combination because of processed meats, excess cheese, and a refined flour base. It is high in saturated fats and sodium, with minimal nutritional benefits.

Garlic Bread: 2/10

Primarily refined carbohydrates topped with butter, garlic bread offers little beyond empty calories and should be consumed sparingly.

Alfredo Pasta: 2/10

Loaded with cream and refined pasta, this dish is high in fat and low in fibre, making it heavy and nutritionally poor.

Vada Pav: 3/10

A deep-fried potato patty inside a refined bun creates a carbohydrate-heavy, low-protein meal that can spike blood sugar quickly.

Pav Bhaji: 6/10

The bhaji contains a mix of vegetables, making it relatively nutrient-rich. However, excess butter and refined pav reduce its health quotient.

Chhole Bhature: 2/10

Deep-fried bhature paired with heavy chhole makes this a calorie-dense, gut-straining combination that can lead to insulin spikes.

Mandholia concluded that even when it comes to a cheat-day diet, moderation and smart swaps can make even cheat meals a little kinder to your health.