Attention deficit hyperactivity disorder (ADHD) is a neurodevelopmental disorder that affects millions of people, both children and adults. The key characteristics are hyperactivity, impulsivity, and inattention. Because of many obstacles, researchers have been searching for other therapies—inclining to include diet intervention to control the symptoms of ADHD more effectively. One interesting area of research is that for chili peppers! Yes, you read it correctly, scientists are studying the effects of chilli peppers in order to help ease symptoms of ADHD through their action on gut microbiota and the gut-brain axis.

The gut-brain axis (GBA) is a two-way communication system that connects the gastrointestinal tract with the central nervous system. It has significant roles in brain function, emotional control, and cognitive processes. The most recent research indicates that gut microbiota- bacteria living in the digestive system can potentially affect ADHD by impacting the production of neurotransmitters and brain structure.

People with ADHD tend to have reduced levels of healthy gut bacteria, including Lactobacillus, and a less diverse gut microbiota. This imbalance can contribute to greater neuroinflammation and oxidative stress, both of which are involved in ADHD pathology.

Gut microbiota also control the production of dopamine and serotonin, two neurotransmitters critical for attention, impulse control, and emotional stability.

Can Chili Peppers Be A Natural Treatment For ADHD?

Chili peppers have bioactive molecules, such as capsaicin, vitamin C, and polyunsaturated fatty acids (PUFAs), that could affect symptoms of ADHD through modulation of the gut microbiota and neurotransmitter concentration.

Capsaicin, the phytochemical in chili peppers, has been found to modulate neurotransmitter levels. Experiments with animals reveal that capsaicin boosts the levels of serotonin and dopamine in the brain, which has the potential to enhance attention and impulse control.

Additionally, capsaicin has been shown to inhibit neuroinflammation and oxidative stress, both of which are associated with ADHD pathology. Through the reduction of these variables, capsaicin could help to decrease some ADHD symptoms. While animal models offer promising information, human studies are needed to ascertain if capsaicin supplementation can produce a concrete effect on ADHD symptoms.

Role of Vitamin C and Gut Microbiobe

Chili peppers are a rich source of vitamin C, a potent antioxidant that enhances immune function, neurotransmitter production, and iron absorption. New evidence indicates that vitamin C can also increase the prevalence of helpful microbes such as Lachnospiraceae in the gut microbiota. Gut microbial balance has been implicated in neurodevelopmental diseases such as ADHD, and vitamin C's activity in regulating gut microbes could potentially be used as a therapy.

Moreover, vitamin C also decreases brain inflammation, which tends to be higher in patients with ADHD.

Chili peppers are also rich in PUFAs, such as omega-3 and omega-6 fatty acids. Studies have established that patients with ADHD tend to have lower levels of omega-3 PUFAs, which are important for brain function, synaptic plasticity, and regulation of neurotransmitters. Omega-3 supplementation has been shown to enhance memory function and boost short-chain fatty acid (SCFA)-producing gut bacteria, which promote brain and gut health.

Given that PUFAs have anti-inflammatory properties and maintain cognitive function, their occurrence in chili peppers contributes to the accumulating data indicating dietary intervention may be effective in modulating ADHD symptoms.

Although chili peppers have bioactive substances that could affect the gut-brain axis and help alleviate ADHD symptoms, their impact is speculative until stricter human trials are carried out. Being a readily available food item, peppers can be used as a possible adjunct therapy, which can be added to conventional ADHD treatments. Peppers, however, cannot be used as a substitute for established medical therapies, including behavioral therapy and prescription drugs.

The developing connection between nutrition, gut microbiome, and ADHD has paved the way for exploring non-medication interventions. Chili peppers, rich in capsaicin, vitamin C, and PUFAs, represent a novel yet unproven method for modulating ADHD symptoms. While early research points towards a possible intervention by chili peppers in modulating neurotransmitter content and minimizing neuroinflammation, human studies are essential to validate the observations.

A compound your body makes after eating pomegranates, walnuts and some berries has improved heart function by up to 80% in lab models of a form of heart failure that's notoriously hard to treat. The finding comes from King's College London, and it's early, but it points at a problem doctors have struggled with for years.

The Condition With Few Treatments

The heart failure in question is called heart failure with preserved ejection fraction, or HFpEF. Here, the heart still pumps blood normally, but becomes too stiff to relax and fill properly between beats. It causes breathlessness, fatigue and a poorer quality of life, and accounts for roughly half of all heart failure cases in the UK, affecting nearly half a million people, according to King's College London's release, carried by ScienceDaily.

HFpEF has long resisted treatment because it's driven by many overlapping factors, including ageing, high blood pressure and diabetes, King's College London says. One class of diabetes drugs, called SGLT2 inhibitors, has recently changed that picture. Large trials named EMPEROR-Preserved and DELIVER found that the drugs empagliflozin and dapagliflozin cut deaths and hospital visits in HFpEF patients, and empagliflozin became the first SGLT2 inhibitor approved in the US specifically for HFpEF, according to TCTMD. But researchers still call the field wide open.

Also Read: Heart Valve Clips Explained: How a Tiny Clip Can Help Repair a Leaking Valve

What The New Study Found

Researchers led by Dr. Joseph Burgoyne found that a compound called urolithin A activates a protein named PKGIα, which helps blood vessels and heart muscle relax, King's says. In animal models of HFpEF, urolithin A improved heart function measures by as much as 80%, helped heart tissue relax better, and reduced fibrosis, the scarring that interferes with normal heart function. It also limited harmful enlargement of heart muscle cells.

The team then tested the compound in engineered human heart tissue grown from stem cells, a lab model that closely mimics real heart muscle. Urolithin A significantly improved relaxation there too, according to King's, suggesting the animal results might carry over to humans.

Notably, urolithin A has already been studied in people and has shown a good safety record, King's says. But your body doesn't get it directly from food. Instead, gut bacteria produce it by fermenting compounds found in pomegranates, walnuts and berries, according to the Global Prebiotic Association, a nutrition industry group. That means how much urolithin A a person makes can depend on which gut bacteria they have, not just what they eat.

Not A Reason To Stock Up On Pomegranates Yet

Burgoyne was careful about what the findings mean. "While there isn't enough evidence to suggest that people should eat pomegranates to treat heart failure, these findings raise the possibility that dietary approaches that enhance urolithin A production may help alleviate this condition," he said, per King's.

Professor James Leiper of the British Heart Foundation, which funded the study, struck the same note: "These findings are promising, but the benefits have so far been seen in animals and engineered human tissue, so clinical trials involving people are needed." He added that a healthy, balanced diet is still one of the best ways to protect the heart, but "no single food can prevent or treat heart disease on its own."

There is a reason why when we think about coffee, we only see ‘caffeine’ in big, bold letters. It helps up wake up, stay energetic, alert, sharpens our attention and helps us fight the midday grogginess at work. So, little attention has been paid to other components of coffee.

But new research suggests some of coffee’s effects on the brain may have little to do with caffeine.

A study published in Nature Communications found that both caffeinated and decaffeinated coffee were linked to changes in the gut microbiome, mood and stress. But improvements in learning and memory were seen specifically among people who drank decaffeinated coffee.

The findings suggest that coffee’s effects on the brain could involve its many other compounds and the gut-brain connection, rather than caffeine alone.

How Was The Study Conducted

Researchers from APC Microbiome Ireland at University College Cork studied 62 people. Thirty-one were regular coffee drinkers, while 31 did not normally drink coffee.

The regular coffee drinkers first stopped consuming coffee for two weeks. Researchers then collected stool and urine samples and monitored their mood, stress, cognition and other measures.

Coffee was subsequently reintroduced, with participants receiving either caffeinated or decaffeinated coffee for three weeks. The researchers found that both forms of coffee were associated with changes in gut bacteria and metabolites. But when it came to cognitive effects, there was a striking finding.

Also read: Andrew Huberman’s Sleep Trick: Can Eye Movements Help You Fall Back Asleep?

Decaffeinated Coffee Improved Memory

Participants who drank decaffeinated coffee showed significant improvements in learning and memory. For example, they made fewer errors on a test examining learning and memory. They also showed improvements in episodic memory, which involves remembering information and experiences.

The caffeinated group did not show the same results. This helped researchers find out that the non-caffeine components of coffee may have some positive cognitive effects.

But the researchers also acknowledge that some of the improvement could have happened due to participants becoming more familiar with the tests over time.

Also read: Gut Microbiome Linked To 3x Higher Type 1 Diabetes Risk In Children

Decaf Coffee's Effect On Brain

Coffee contains thousands of chemical compounds, including polyphenols. These compounds can interact with gut microbes and influence the production of metabolites, which can then affect the body and brain. This is where the gut-brain axis comes into the picture.

The gut and brain are in constant communication through several processes involving the nervous system, immune system, hormones and chemicals produced by gut bacteria.

The study found that coffee consumption altered the composition and activity of gut microbes and changed certain metabolites. Some bacteria, including Eggerthella species and Cryptobacterium curtum, were more found in more quantity among coffee drinkers.

Researchers believe these microbial changes could help explain some of coffee’s effects on mood and cognition.

Effects Of Caffeinated Coffee

Participants drinking caffeinated coffee experienced reduced anxiety and other psychological effects, while some measures of attention and cognitive performance also improved.

Both caffeinated and decaffeinated coffee showed lower signs of stress, depression and impulsivity.

So the study does not suggest that decaf is universally better for the brain. Instead, it shows that different components of coffee may produce different effects.

It also adds another layer to the increasingly complicated story of coffee and health. Coffee may be more than a delivery system for caffeine. Its polyphenols and other compounds may interact with gut bacteria, influencing metabolism, inflammation, mood and brain function.

Red Bull got relief after Delhi High Court overturned a Food Safety and Standards Authority of India (FSSAI) order that instructed the Austrian beverage giant to drop its ‘energy drink’ label. In a recent ruling, the court made its decision after it found that the Indian food regulator did not give sufficient time to the company to present its case.

While the legal fight between the food regulator and the billion-dollar beverage giant boils down to just two words on a can, the health question is much bigger: What does drinking an energy drink like Red Bull actually do to the body?

FSSAI Vs Red Bull

FSSAI had said India does not have a notified food standard specifically defining an “energy drink”, objecting to brands like Red Bull making claims like boosting energy or enhancing focus.

The regulator's concerns also included linked to what these beverages actually contain, particularly excessive caffeine, sugar, and other controversial ingredients like taurine.

The biggest concern that the lawsuit is built upon is what causes the sudden surge of ‘energy’ after someone consumes this drink. Is it giving your body useful energy?

Also read: High Sugar, Salt Or Fat? India May Mandate Red Hexagon Labels On Food Packs

Red Bull’s Ingredients And What It Does To Your Body

Caffeine

One of the main ingredients responsible for the immediate feeling of energy alertness is caffeine. Caffeine stimulates the central nervous system, making you feel more awake and less tired. But that boost does not mean the drink is providing the body with sustained energy in the nutritional sense.

Depending on the product, energy drinks can also contain substantial amounts of added sugar, which adds calories but does not make the drink healthier.

The caffeine content of energy drinks varies considerably. The US FDA notes that energy drinks can contain roughly 41 to 246 mg of caffeine per 12 fluid ounces, depending on the product.

The energy boost claim may comes from the caffeine content, which is what consumers should be mindful about. Too much caffeine can lead to faster heartbeat, palpitations, increased blood pressure, anxiety, jitters, headaches, nausea and sleep disruption. For most healthy adults, the FDA cites 400 mg of caffeine a day.

Also read: Every Extra 100g Ultra-Processed Food Linked To 14% Higher Heart Risk, 11% Higher BP Risk

Energy drinks can also temporarily increase blood pressure and cardiovascular load. A 2024 review and meta-analysis of randomised trials found that energy drinks acutely increased systolic and diastolic blood pressure in healthy adults.

Excess caffeine in young people can cause palpitations, increased heart rate and blood pressure, anxiety, sleep problems and digestive symptoms. Therefore, the FDA and medical experts advise against energy drinks for children and teenagers.

This is also why energy drinks have attracted regulatory restrictions worldwide. England, for example, plans to prohibit their sale to under-16s from April next year.

Sugar

The sugar content is another reason to be careful about how often you drink energy drinks. Regular and frequent consumption of high amounts of added sugar, through liquid calories like energy drinks, can increase overall calorie intake and contribute to weight gain and obesity.

Over time, excess sugar intake is also linked with a higher risk of metabolic problems like type 2 diabetes and fatty liver disease. For people who regularly consume these energy drinks, the concern is therefore not just the caffeine, but also how much added sugar they are consuming with each can.

Taurine

HealthAndMe previously reported that taurine may help fuel the growth of certain leukaemia cells. The research raised questions about taurine's role in blood cancer. The research was about the behaviour of cancer cells and does not establish that taurine-laced energy drinks cause blood cancer in humans.

Taurine occurs naturally in protein-rich foods like meat and fish and is also produced in the human body. Known for its function of maintaining fluid balance, cardiovascular support, and electrolyte regulation, taurine has been touted for years as a "health-enhancing" supplement. Taurine is also added to energy drinks for its claimed brain-boosting and anti-inflammatory effects and is marketed as a means to enhance mental concentration and physical output.

A study by University of Rochester's Wilmot Cancer Institute revealed how leukemia cancer cells hijack taurine as an energy source. Specifically, the cancer cells take in taurine to fuel glycolysis—a biological process that allows them to produce energy and proliferate at a fast rate.

The bottomline is that the Delhi High Court's ruling does not mean that Red Bull has been declared healthy. It addresses whether FSSAI followed the correct procedure when restricting the “energy drink” label. So even though Red Bull can be marketed and sold as an “energy drink”, it cannot be automatically considered healthy.