Did this ever happen that you drank coffee but did not feel energetic? Instead, you went right into your bed and slept off. Like we all know, have hard, and seen proofs too that coffee, or caffeine makes us feel alive, and energetic. This is one drink workaholics swear by. But what happens when it no longer makes you feel that way. Ever wondered why?Many people, including journalist Amy Glover, who writes for Huffpost said that for drinking coffee for her was never to perk her up. She always felt that it made her sleepier. After doing some research herself, she found out that smoking, oral contraceptives, and caffeine "tolerance" among regular drinkers may cause some to feel ready to rest!Dr Karan Rajan, gastrointestinal surgeon, author, and lecturer who posts health content on his Instagram channel @drkaranrajan talks about coffee and the glitch it causes to some people, which is why they feel tired. View this post on Instagram A post shared by Dr Karan Rajan (MRCS MBBS BSc) (@drkaranrajan)]]> In his video he says, "If caffeine makes you feel tired, it might be because of a software glitch in your caffeine gene". So, what does that really mean?Why Do You Feel Tired After Drinking Coffee?The way your body responds to caffeine depends on a type of liver enzyme called CYP1A2. This enzyme affects how sensitive your body is to caffeine. The doctor says, "depending on your metabolism, it could take between two to eight hours to remove half of the caffeine" you have drunk from your system. This is important because caffeine blocks the adenosine receptors, these are the hormones that tells us when we are sleeping. However, if you metabolise coffee faster, your receptors will be unblocked sooner and you will feel tired. As per a 2023 study published in JAMA Network, titled CYP1A2 Genetic Variation, Coffee Intake, and Kidney Dysfunction, it was noted that those with a "slower" functional liver enzyme, could develop kidney conditions than those who do not have any caffeine's effects. The doctor too agreed that the caffeine tolerance theory is what happens in your body and leads to you feel tired or active. Is There Something To Worry About?Now the biggest question that follows through is if you do not feel active after drinking coffee, is there something wrong with your body? Should you be worried? As per the Sleep Foundation, it says that this could lead to a vicious sleep cycle. If you are not active by drinking coffee, you might drink more to stay alert and active. However, this might make you feel tired at the moment, but keep you up later in the night. This will make you feel more tired in the morning, and you will eventually drink more coffee then. Again, this won't work on your system, but you will be active at night, and this is how the cycle continues.There are also those theories that claim that if you feel tired after drinking coffee, you might have ADHD. While this may seem counterintuitive, but it can be attributed to the unique neurobiology of individuals with ADHD. Research also suggests that people with ADHD may have a unique dopamine regulation in their brain, which is why they react differently and feel tired after consuming coffee.