Autism has increased significantly since 2000, particularly in the US, triggering public concern about what might contribute ot its prevalence. In November, Robert F Kennedy Jr, who was selected to lead the US Department of Health and Human Services (HHS), linked autism to childhood vaccinations. Soon, medical experts jumped on it to discredit his claim. But then many raised this question: if autism is not caused by vaccines, then what causes this neurological disorder?

Research tells us that autism tends to run in families, and a meta-analysis of 7 twin studies claims that 60 to 90% of the risk of autism comes from your genome. If you have a child with autism, you are more likely to have another autistic child. Your other family members are also more likely to have a child with ASD.

Changes in certain genes or your genome increase the risk that a child will develop autism. If a parent carries one or more of these gene changes, they may get passed to a child (even if the parent does not have autism). For some people, a high risk for ASD can be associated with a genetic disorder, such as Rett syndrome or fragile X syndrome. For the majority of autism cases, multiple changes in other regions of your DNA increase the risk of autism spectrum disorder. The majority of these DNA changes do not cause autism by themselves but work in conjunction with many other genes and environmental factors to cause autism.

If you or your child has ASD, we recommend that you explore genetic testing. Genetic testing could show you the genetic cause of you or your child’s autism and reveal any genetic mutations that might be linked to serious co-occurring conditions like epilepsy. Genetic testing can give doctors useful information so they can provide better, more personalized interventions. Read two families' stories on how genomics helped their understanding of autism and receiving personalized healthcare.

What environmental factors are associated with autism?

According to the National Institute of Environmental Health Sciences, certain environmental influences may increase autism risk:

• Advanced parental age
• Prenatal exposure to air pollution or certain pesticides
• Maternal obesity, diabetes or immune system disorders
• Extreme prematurity or very low birth weight
• Birth complications leading to periods of oxygen deprivation to the baby’s brain

Oxytocin, commonly referred to as the "love hormone" because it is involved in bonding and social behavior, is now being investigated for its surprise effect on pregnancy. Although oxytocin is traditionally linked to childbirth, milk letdown during lactation, and emotional bonding, recent findings indicate that this hormone can possibly delay early pregnancy. A study on mice conducted recently has helped explain how the hormone can stop embryonic growth, which may provide new understanding of human fertility and pregnancy.

In a few mammals, such as marsupials, bats, and more than 130 others, a process called "diapause" takes place. This is a natural biological phenomenon that sees embryos suspend their development in order to wait until the right conditions prevail for pregnancy to resume. Although very uncommon and hard to monitor in human beings, clinical experience from in vitro fertilization clinics indicates that human embryos might at times show delayed implantation. One highly documented case in 1996 showed that an embryo implanted in a uterus was in a suspended state for five weeks before implantation took place.

The new research by scientists at the NYU Grossman School of Medicine investigated oxytocin's possible role in inducing this pause in pregnancy. Their results indicate that oxytocin could be a major player in controlling diapause in mice, and they raise questions about its possible role in human pregnancies.

Oxytocin-Induced Pregnancy Pause

To study the impact of oxytocin on pregnancy, scientists tested female mice who had recently given birth by letting them be mated while still lactating. The research revealed that nursing females had pregnancies that lasted about a week longer than those of the non-nursing mice. Since the normal pregnancy in mice takes only 19 to 21 days, this postponement is a drastic halt to embryonic development.

The research team then sought to determine how this pause occurred. Using optogenetics, a technique that enables the activation of specific neurons through light stimulation, they artificially triggered the release of oxytocin in pregnant mice. After five days of oxytocin stimulation, the researchers examined the mice’s uteruses and found that five out of six had embryos in a dormant state, indicative of diapause. Conversely, pregnant mice that were not administered oxytocin stimulation did not exhibit any indication of developmental arrest.

In further confirmation of their research findings, the scientists administered oxytocin to early-stage mouse embryos in the laboratory setting. They detected identical cellular alteration related to diapause, implying that oxytocin has a direct influence on suspended embryonic development.

How Oxytocin Affects Embryonic Development?

The research showed that oxytocin slows down the process through which embryonic cells convert genetic information into proteins. This process, essential for growth and development of the cell, is copying DNA instructions into RNA, which then guides protein synthesis. By suppressing this process, oxytocin puts the embryo into suspended animation.

Interestingly, scientists also learned that embryos without oxytocin receptors were still able to enter diapause, suggesting that more than one biological pathway is used to trigger the pause. Still, having working oxytocin receptors seemed to increase the embryo's chances of surviving the halted state. When oxytocin receptors in the embryos were deactivated, survival rates while in diapause fell to 11% from 42%.

Implications for Human Fertility and Pregnancy

Although this research is in its infancy, it presents exciting possibilities for human fertility studies. A better grasp of the role oxytocin plays during early pregnancy may lead to significant advances in treating unexplained infertility and recurrent miscarriage. If human embryos can enter a state of diapause, further study could reveal how hormonal or environmental influences are responsible for early pregnancy loss.

Also, these discoveries may have greater implications outside pregnancy. As oxytocin is implicated in cell survival, researchers now want to know if what it does in diapause can help understand how to keep nerve cells from dying in the developing nervous system. What stops cells from dying early on might help neurobiology and regenerative medicine advance.

Even with these thrilling findings, much remains to be answered. How long can diapause be in various species, including humans? What are other biochemical signals that cooperate with oxytocin to control embryonic development? And might this information one day lead to targeted fertility treatments or interventions?

More studies are needed to uncover these secrets. As researchers learn more about the multifaceted functions of oxytocin, its image as just the "love hormone" is changing. This potent molecule seems to play a much more intricate function in reproductive biology than has been known, and it may play a role not only in when life starts, but in when it temporarily gets suspended.

Oxytocin's role in pregnancy is turning out to be more complex than originally thought. Though still a primary force behind labor and maternal attachment, it has also recently been found to retard embryonic development, which could have far-reaching consequences for reproductive science. As more research unfolds, the hormone could provide new insights into fertility, enhance IVF success, and even prevent early miscarriage. The possibility of oxytocin-based fertility therapies is an exciting one, and future research will be important to determine how this information can be translated to human pregnancy.

A study published in the New England Journal of Medicine has listed five key factors that impact the longevity of individuals. The research tracked participants for up to 47 years, assessing how five specific factors influenced their risk of death, longevity, and the number of healthy years they could gain by altering these habits. The conclusions of this study were based on data analyzed from over two million adults aged 18 and above across 39 countries.

Five Factors That Influence Longevity

• High blood pressure
• High cholesterol
• Diabetes
• Smoking
• Bodyweight, including being overweight and underweight

Women Could Add 14 Years To Their Lives

As per the researchers, women who didn't have these five risk factors at age 50 could potentially add more than 14 years to their lives, and men could gain almost 12 additional years. Men were most affected by these factors as those with all five faced a 94% chance of dying before 90, while their counterparts without these issues had just a 68% chance. Women with all five risk factors at age 50 had an 88% chance of dying before 90, whereas those without these problems had a 53% chance.

Diabetes Is The Main Factor

Out of all the factors, cholesterol was the least impactful of all. As per the study, people who lowered their cholesterol levels could only add 1.2 extra healthy years to their lifespan. On the contrary, individuals who quit smoking could potentially extend their lives by up to six years. Women who do not have diabetes could gain an extra 6.4 years, while men without the condition might see an increase of 5.8 years. Even a slight reduction in blood pressure could lead to an additional 1.8 healthy years, and achieving a normal BMI could contribute an extra 2.6 years, with variations depending on the region.

Importance Of Lifestyle Changes

The study reinforces the importance of lifestyle modifications in extending a healthy lifespan. The researchers noted that small but consistent changes in daily habits could significantly impact longevity. For example, maintaining an optimal weight through a balanced diet and regular physical activity helps control blood pressure, diabetes, and cholesterol levels, reducing overall health risks.

Smoking cessation emerged as the most crucial lifestyle change that could dramatically influence lifespan. Quitting smoking, even later in life, significantly reduces the risk of cardiovascular diseases, lung disorders, and certain cancers, contributing to longer and healthier lives. Similarly, diabetes management through dietary changes, regular exercise, and proper medical intervention plays a vital role in preventing complications and enhancing longevity.

Regional And Gender-Based Differences

The study also highlighted variations in longevity gains based on gender and geographical regions. For instance, men were more susceptible to the adverse effects of these five risk factors than women. This disparity could be attributed to lifestyle differences, genetic predisposition, or healthcare access.

Additionally, in certain countries with high obesity rates, maintaining a normal BMI was one of the most significant contributors to longevity. Meanwhile, in regions with lower tobacco consumption, factors like high blood pressure and diabetes had a more prominent role in affecting lifespan.

Chewing gum can release thousands of microplastics into the saliva that may be ingested, new study has found. This research, presented at the spring meeting of the American Chemical Society in San Diego, US and published in a peer review journal, found that, on average, 100 microplastics were released per gram of chewing gum—both synthetic and natural. The research came in at a time when health experts across the world have raised alarms over the hazardous impact of microplastics on the human body.

"Our goal is not to alarm anybody," Sanjay Mohanty, PhD, the principal investigator and an engineering professor at the University of California, Los Angeles (UCLA), said in a press statement. "Scientists don’t know if microplastics are unsafe to us or not. There are no human trials. But we know we are exposed to plastics in everyday life, and that's what we wanted to examine here."

Microplastics are parts of plastics that are smaller than 5 millimeters in length. Studies conducted in the past have revealed that an individual consumes between 39,000 and 52,000 particles of microplastic annually. They are everywhere, and humans may be exposed to them through drinks, foods, plastic packaging, chopping boards, sponges, coatings on products, and the manufacturing process of items. Interestingly, their presence in chewing gums wasn't widely researched but not anymore.

5 Steps You Can Take To Reduce Microplastic Accumulation In Your Body

A recent study has shown that switching from bottled water to filtered tap water could cut microplastic intake by about 90%—from 90,000 to 4,000 particles each year. Teeny bits of plastic break off from the inner side of plastic bottles and become a part of the water, particularly when the bottle is squeezed or exposed to heat. Over time, these particles accumulate in the body and may pose long-term health risks, although the exact effects are still being studied.

It is recommended to use a stainless steel, glass, or copper reusable water bottle with filtered water to reduce microplastic consumption. Not only is this better for your health, but also a more sustainable alternative for the environment.

Choose Right Tea Bags

A 2019 Canadian study revealed that steeping a single plastic tea bag at brewing temperature (203 degrees Fahrenheit) releases about 11.6 billion microplastics and 3.1 billion nanoplastics into each cup.

“We think that it is a lot when compared to other foods that contain microplastics,” researcher Nathalie Tufenkji at McGill University in Quebec told *New Scientist*. “Table salt, which has a relatively high microplastic content, has been reported to contain approximately 0.005 micrograms of plastic per gram of salt. A cup of tea contains thousands of times greater mass of plastic, at 16 micrograms per cup.”

To avoid too steep (pun intended) health consequences, experts recommend using paper or loose-leaf tea bags instead. Choosing tea brands that specifically mention plastic-free packaging can also help reduce your intake.

Boil And Filter Tap Water

In many cultures, boiling water before drinking it is an ancient custom and/or necessary for survival. Research suggests that when it comes to microplastics, the intervention could be just as critical.

A 2024 study found that boiling water can quickly and effectively rid home drinking supplies of microplastics. Researchers found that boiling and filtering tap water could reduce the microplastics (and nanoplastics) in water by nearly 90%. How does it work? As the water temperature rises, the limescale — that chalky residue left in water kettles — interferes with the plastics, absorbing them and removing them from the water.

Avoid Other Everyday Plastic Sources

Your kitchen may be another source of exposure. Plastic cutting boards, for example, can shed tiny bits of plastic during food prep, which may end up in your meals. Similarly, heating food in plastic containers — especially in the microwave — can cause plastics to break down and leach harmful particles into your food.

Simple changes such as switching to wooden or glass cutting boards, and using ceramic or glass containers for heating food, can go a long way in reducing your daily microplastic intake.

While avoiding microplastics altogether may not be possible, these small steps can help you significantly reduce your exposure and protect your long-term health.