We all must have come across the phase: this is why women live longer than men. These are all over the social media, where men are performing more often than not, some experiments, without gears, just for fun, "in the name of science". The caption reads: this is why women live longer. However, is there really a science to it, other than the fact that women choose to do things more safely?

In the United States, women have a life expectancy of about 80, whereas men have 75. Women outlive men and this holds true regardless of the country women live, the money they make, and other factors. In fact, it is true for most other mammals too.

Dr Dena Dubal, a professor of neurology at the University of California, San Francisco told the New York Times, "It is a very robust phenomenon all over the world, totally conserved in sickness, during famines, during epidemics, even during the times of starvation."

But what are the reasons? These reasons are often more complicated and less established. It is important to note that only because women are outliving men does not mean they are living a better life. In fact, women tend to have shorter health spans, which means the number of healthy years in a person's life is less in women than men, confirmed Bérénice Benayoun, an associate professor at the U.S.C. Leonard Davis School of Gerontology.

As per a 2021 study titled, Sex differences in frailty: Comparisons between humans and preclinical models, found that women are more physically grail than men in old age. They are also more vulnerable, especially after menopause and are at more risk of developing cardiovascular issues and Alzheimer's disease because of age.

The key is in figuring out what makes one sex more resilient or vulnerable.

Genetics

For things which do not find easy explanations, scientists look for their answers in genes. Many research, including a 2020 study titled, The sex with the reduced sex chromosome dies earlier: a comparison across the tree of life, suggests that the XX set of female sex chromosomes may impact longevity. However, there has not been any clarity on how it affects longevity.

Another 2018 study titled, Female XX sex chromosomes increase survival and extend lifespan in aging mice, which was conducted by Dr Dubal's lab, looked at genetically manipulated mice with different combinations of sex chromosomes and reproductive organs. It was found that those with two X chromosomes and ovaries lived longest, followed by mice with two X chromosomes and testes. Mice with XY chromosomes had shorter life spans.

"There was something about the second X chromosome that was protecting the mice from dying earlier in life, even if they had testes. What if there was something on that second X chromosome that was in some ways a sprinkle of the fountain of youth," says Dr Dubal. While scientists have not yet looked at this factor in humans, Dr Dubal suggests that humans have the same hormones and sex chromosomes, and similar reproductive system that could corroborate the similar findings in people.

Hormones

Plenty research has shown that estrogen is responsible for longevity also effect on the immune system. The data also shows that before menopause, the female immune system tends to do better. In fact Dr Benayoun said that males tend to do much worse in response to infection.

Another 2017 study titled, Ages at Menarche and Menopause and Reproductive Lifespan As Predictors of Exceptional Longevity in Women: The Women's Health Initiative, found that women who experienced menopause later in life over the age 50 lived longer than those who experienced it earlier.

Lifestyle and Behavior

There are also disparity in behavioral patterns between men and women. This includes smoking, drinking heavily, which can contribute significantly to mortality. Women also have more "health promoting behavior", believe experts. Women are also more likely to socialize than men and thus it protects them from detrimental effects of social isolation and loneliness. In fact, a 2023 analysis published in Jama Network, titled, Widening Gender Gap in Life Expectancy in the US, 2010-2021, found that women are less likely to die by drug overdose or suicide.

A new, highly mutated COVID variant called 'Cicada' is spreading in the US. This is the BA.3.2 mutation of the COVID-19 variant. While nationally the cases of COVID have remained low, the BA.3.2 strain is gaining traction across the globe.

What Is The Cicada COVID Variant?

Cicada or the BA.3.2 strain emerged over a year ago, and simmered until last fall. However, this was when it started ramping up in countries including the US. As of February, BA.3.2 has been detected in at least 25 states, noted the US Centers for Disease Control and Prevention (CDC).

The variant's slew of genetic changes in its spike protein is what has made people concerned. This is what makes it unique and distinct from other variants in circulation.

According to Andrew Pekosz, Ph.D., a virologist at the Johns Hopkins Bloomberg School of Public Health, as reported by TODAY.com, "It [the variant] has a lot of mutations that may cause it to look different to your immune system."

The SARS-CoV-2 virus that causes COVID-19 mutates constantly and spreads over time. It thus leads to emergence of new variants.

A new study published in the CDC’s Morbidity and Mortality Weekly Report suggests that emerging variants could weaken protection gained from prior COVID-19 infection or vaccination.

One such “hyper-mutated” strain, BA.3.2, is now being closely tracked by public health officials. In December 2025, the World Health Organization classified it as a “variant under monitoring.”

Read: COVID Variant BA.3.2 Spreads To 23 Countries: Is The Variant Under Monitoring A Cause Of Worry?

When Was Cicada COVID Variant First Detected?

BA.3.2 was first detected in South Africa in November 2024. It is a descendant of BA.3, an Omicron subvariant that appeared in 2022 and briefly circulated alongside BA.1 and BA.2, according to the CDC.

Although BA.3 never became dominant, it did not completely disappear. “It fizzled out, but persisted at low levels,” said Pekosz. After two years and dozens of mutations, BA.3.2 eventually emerged.

For much of 2024, the variant spread quietly, overshadowed by dominant strains like Nimbus and XFG, which stem from BA.2. However, by September, BA.3.2 began gaining ground. “It was under the radar, replicating, until it started spreading more efficiently between people,” Pekosz noted.

What sets BA.3.2 apart is its spike protein, which carries an unusually high number of mutations — around 70 to 75. This makes it significantly different from strains such as JN.1 and LP.8.1, which current COVID-19 vaccines are designed to target.

The CDC describes BA.3.2 as a “genetically distinct” lineage compared to recent variants. Early laboratory studies suggest it may be capable of evading existing immunity, as its spike protein changes help it escape neutralising antibodies.

What Makes Cicada So Unique?

The BA.3.2 variant is nicknamed by T Ryan Gregory, Ph.D., a professor of evolutionary biology at the University of Guelph. He wrote on X, formerly Twitter: "Well, it's that time again. Meet "Cicada", BA.3.2* (including descendant RE.*). This one has been underground for years (its ancestor BA.3 hasn't been circulating since early 2022, and didn't do much then either) but is now emerging as a contender for the next major lineage."

While most of the symptoms of this new variant remains same as from the other variants, one thing that stands out here is the gastrointestinal symptoms that cicada could cause. However, experts note that this variant will not make anyone more sicker. Other symptoms include:

• Cough
• Fever or chills
• Sore throat
• Congestion
• Shortness of breath
• Loss of smell or taste
• Fatigue
• Headache

On March 13, the Ministry of Social Justice and Empowerment introduced the Transgender Persons (Protection of Rights) Amendment Bill, 2026, in the Lok Sabha. Amid opposition, the Rajya Sabha gave its not to the Bill on March 25. The bill seeks to amend the Transgender Persons (Protection of Rights) Amendment Act 2019. The bill was passed in the Lok Sabha on March 24.

What Makes The Bill So Controversial?

What the law originally promised: India's legal framework for transgenders rights comes from the landmark NALSA v. Union of India ruling. This is where the Supreme Court recognized transgender persons as 'third gender' and affirmed their fundamental rights, including access to healthcare. The 2019 amendment followed and promised non-discrimination in education employment, housing, and crucially, healthcare. As per a Live Law analysis, the law was intended to align with constitutional guarantees of equality and dignity, especially under Article 14 (Equality Before Law), 15 (Prohibition of Discrimination), and 21 (Right To Life).

Recent amendments have however raised concerns because of how it could reshape access to healthcare and recognition of identity.

What Does The New Bill Introduce?

The Bill introduces stricter verification of identification and tightens the definition of transgender identity by replacing self-identification with mandatory medical certification. This, many argue is against the 2019 Act supported by the NALSA judgment.

'We, the transgender people of India, reject the erasure of our identity," writes Dr Aqsa Shaikh for the media outlet - The Indian Express. One of the biggest concerns she and many pointed was the continued requirement of official certification for gender identity.

While the law does not always explicitly mandate surgery, activists argue that in practice, access to updated identity documents often becomes tied to medical procedures.

This creates barriers to gender-affirming healthcare, which includes hormone therapy, surgeries, and mental health support.

Dr Shaikh, who is a transgender professor at the Department of Community Medicine in Hamdard Institute of Medical Sciences and Research, Jamia Hamdard, argues that such provisions undermine the principle of self-identification, which was central to the NALSA judgment.

Gaps In Gender-Affirming Healthcare Access

Experts have long pointed out that transgender healthcare in India is already limited:

• Few public hospitals offer structured gender-affirming services
• Mental health support tailored to transgender individuals remains scarce
• Hormone therapy is often accessed informally without supervision

Critics also argue that the amendments do little to expand healthcare infrastructure, focusing instead on administrative control.

Health activists have also flagged the absence of:

• Universal insurance coverage for gender-affirming procedures
• Clear funding commitments for public healthcare services
• Standardized treatment protocols across states

This is significant because transgender individuals face disproportionately high rates of:

• Depression and anxiety
• Substance use disorders
• Suicide risk

Without systemic healthcare guarantees, the law’s protections risk remaining symbolic.

Erasure Of Identity

An opinion piece in The Leaflet describes this bill as an "architecture of erasure". The piece argued that it weakens recognition of diverse transgender identities by reinforcing bureaucratic control. Dr Shaikh argues that the community rejects any framework that takes away the right to self-identify, calling it a rollback of constitutional morality.

Furthermore, a LiveMint report notes that the amendment is a "hurried, short-sighted decision" because it was passed without adequate consultation with transgender communities, it ignores lived experiences and healthcare needs, and prioritizes regulation over welfare.

Live Law notes that any law that govern transgender rights must remain consistent with the NALSA judgment. However, the recent amendment could dilute the principle supported by NALSA judgment that gender identity is based on self-perception and not state or medical approval.

Metformin Brain: A popular diabetes drug, prescribed to manage type 2 diabetes by controlling blood sugar, which has been in use for 60 years - metformin, now shows how it is directly linked to the brain.

A drug used for over six decades did not have a study that made scientists sure of exactly how it works, until now. Researchers from the Baylor College of Medicine in the US were able to identify in 2025 a brain pathway that the drug seems to work through. It also has impacts on biological processes in other areas of the body.

"It's been widely accepted that metformin lowers blood glucose primarily by reducing glucose output in the liver. Other studies have found that it acts through the gut," said Makoto Fukuda, a pathophysiologist at Baylor.

"It's been widely accepted that metformin lowers blood glucose primarily by reducing glucose output in the liver. Other studies have found that it acts through the gut," said Makoto Fukuda, a pathophysiologist at Baylor.

What the Study Found

In a 2025 study on mice, researchers observed that metformin travels to the VMH and switches off Rap1 activity. This action appears to be crucial for its ability to control blood sugar. To test this further, scientists bred mice that lacked Rap1. In these mice, metformin no longer improved diabetes-like symptoms, even though other medications still worked.

This points to something important. Metformin may be working through a completely different pathway compared to other diabetes drugs, one that depends on the brain.

Read: Metformin Controls Blood Sugar With Help From Brain Neurons, Finds Study

The researchers also identified specific nerve cells involved in this process. They found that SF1 neurons become active when metformin enters the brain, suggesting these cells play a direct role in how the drug works.

Why This Matters

These findings could change how doctors and scientists think about diabetes treatment. If metformin’s brain pathway is confirmed in humans, future therapies could be designed to target these exact neurons, making treatments more precise and possibly more effective.

There is also a bigger picture. Metformin has already been linked to benefits beyond diabetes, including slowing aspects of brain aging and improving longevity. In one study involving postmenopausal women, those taking metformin had a significantly lower risk of dying before the age of 90 compared to those on another diabetes drug.

Read: Metformin Can Help Lower Risk Of Age-related Vision Loss: Study

What Comes Next

While the results are promising, human studies are still needed. If confirmed, this discovery could open the door to new treatments that not only manage blood sugar better but also tap into the brain’s role in overall health and aging.

It also reinforces an emerging idea that metformin is not just acting on the body’s metabolic organs, but quietly influencing the brain at much lower doses.