We all must have come across the phase: this is why women live longer than men. These are all over the social media, where men are performing more often than not, some experiments, without gears, just for fun, "in the name of science". The caption reads: this is why women live longer. However, is there really a science to it, other than the fact that women choose to do things more safely?

In the United States, women have a life expectancy of about 80, whereas men have 75. Women outlive men and this holds true regardless of the country women live, the money they make, and other factors. In fact, it is true for most other mammals too.

Dr Dena Dubal, a professor of neurology at the University of California, San Francisco told the New York Times, "It is a very robust phenomenon all over the world, totally conserved in sickness, during famines, during epidemics, even during the times of starvation."

But what are the reasons? These reasons are often more complicated and less established. It is important to note that only because women are outliving men does not mean they are living a better life. In fact, women tend to have shorter health spans, which means the number of healthy years in a person's life is less in women than men, confirmed Bérénice Benayoun, an associate professor at the U.S.C. Leonard Davis School of Gerontology.

As per a 2021 study titled, Sex differences in frailty: Comparisons between humans and preclinical models, found that women are more physically grail than men in old age. They are also more vulnerable, especially after menopause and are at more risk of developing cardiovascular issues and Alzheimer's disease because of age.

The key is in figuring out what makes one sex more resilient or vulnerable.

Genetics

For things which do not find easy explanations, scientists look for their answers in genes. Many research, including a 2020 study titled, The sex with the reduced sex chromosome dies earlier: a comparison across the tree of life, suggests that the XX set of female sex chromosomes may impact longevity. However, there has not been any clarity on how it affects longevity.

Another 2018 study titled, Female XX sex chromosomes increase survival and extend lifespan in aging mice, which was conducted by Dr Dubal's lab, looked at genetically manipulated mice with different combinations of sex chromosomes and reproductive organs. It was found that those with two X chromosomes and ovaries lived longest, followed by mice with two X chromosomes and testes. Mice with XY chromosomes had shorter life spans.

"There was something about the second X chromosome that was protecting the mice from dying earlier in life, even if they had testes. What if there was something on that second X chromosome that was in some ways a sprinkle of the fountain of youth," says Dr Dubal. While scientists have not yet looked at this factor in humans, Dr Dubal suggests that humans have the same hormones and sex chromosomes, and similar reproductive system that could corroborate the similar findings in people.

Hormones

Plenty research has shown that estrogen is responsible for longevity also effect on the immune system. The data also shows that before menopause, the female immune system tends to do better. In fact Dr Benayoun said that males tend to do much worse in response to infection.

Another 2017 study titled, Ages at Menarche and Menopause and Reproductive Lifespan As Predictors of Exceptional Longevity in Women: The Women's Health Initiative, found that women who experienced menopause later in life over the age 50 lived longer than those who experienced it earlier.

Lifestyle and Behavior

There are also disparity in behavioral patterns between men and women. This includes smoking, drinking heavily, which can contribute significantly to mortality. Women also have more "health promoting behavior", believe experts. Women are also more likely to socialize than men and thus it protects them from detrimental effects of social isolation and loneliness. In fact, a 2023 analysis published in Jama Network, titled, Widening Gender Gap in Life Expectancy in the US, 2010-2021, found that women are less likely to die by drug overdose or suicide.

A 27-year-old woman in US' state of Arizona suffered a cardiac arrest after using kratom, an over-the-counter supplement she purchased at a local gas station.

Amanda Goodsell, who had never taken kratom before, suffered a cardiac arrest after nearly a week of using the supplement and is now on life support, according to her family.

The mother of 3½-year-old twins tried the kratom gummies at the suggestion of her husband, Mike Goodsell, while seeking relief from persistent leg pain.

“Everybody knew what Kratom was. So I was like, well, okay, well, here, just take this. You could just buy it at the gas station. It’s not going to hurt you,” Mike Goodsell was quoted as saying to the media.

Nearly a week later, Mike found his wife unresponsive in their bed, and rushed her to the hospital, where she was placed on life support

“She like, was like red and her lips were blue, and she was foaming. So I like jumped out of bed. I grabbed her, and then (I) was trying to wake her up,” he said.

“They had to have her on a ventilator to help her breathe. And then they had to put her on a bunch of medications because her heart percentage was at 15%,” Mike added.

After spending two weeks in the hospital, Amanda Goodsell's condition began to improve. Although she has shown significant improvement, as per the doctors she will need a defibrillator and heart medication for the rest of her life.

Also read: Legionnaires' Disease Claims 5th Life In New York City: Health Officials

What Is Kratom?

Kratom is a plant-based substance derived from the Mitragyna speciosa tree, native to Southeast Asia. Traditionally used in countries such as Thailand and Malaysia for pain relief and increased energy, it has gained popularity in the US as an over-the-counter supplement.

Kratom is sold in multiple forms, including powders, capsules, teas, drinks and gummies.

Although it remains legal in many parts of the US, the Food and Drug Administration (FDA) has classified kratom as a "drug of concern" and has not approved it for any medical use.

According to the Substance Abuse and Mental Health Services Administration's National Survey on Drug Use and Health, an estimated 1.7 million Americans aged 12 and older used kratom in 2021.

The substance, sometimes referred to as "gas-station heroin," is banned in at least eight US states—Alabama, Arkansas, Connecticut, Indiana, Louisiana, Tennessee, Vermont and Wisconsin. Several other states, including Iowa and Idaho, are considering restrictions or outright bans.

Why Does The FDA Warn Against Kratom?

Read More: Hantavirus Claims 3 Lives In Venezuela: What The Rat-borne Virus Does To The Brain

According to a University of Virginia study, there were 43 hospitalizations linked solely to kratom in 2015. By 2025, that number had risen to 538. Researchers said the increase coincided with the emergence of highly concentrated synthetic products, including 7-OH.

The FDA has stated that kratom should not be used as a dietary supplement.

"Kratom is not appropriate for use as a dietary supplement. FDA has concluded from available information, including scientific data, that kratom is a new dietary ingredient for which there is inadequate information to provide reasonable assurance that such ingredient does not present a significant or unreasonable risk of illness or injury."

The agency has warned consumers not to use kratom because of the risk of serious adverse events, including liver toxicity, seizures and substance use disorder (SUD).

The FDA also notes that, in rare cases, deaths have been associated with kratom use, although these cases usually involved other drugs and the contribution of kratom remains unclear.

The agency is also aware of cases involving neonatal abstinence syndrome, in which newborns experienced withdrawal symptoms such as jitteriness, irritability and muscle stiffness following prolonged exposure to kratom during pregnancy.

When it comes to climate change, we often visualise melting glaciers, rising sea levels, raging wildfires, or record-breaking heatwaves. But scientists are increasingly warning that climate change could also be silently affecting one of the body's most vital organs: the brain.

From rising mercury levels and worsening air pollution to floods, wildfires, and hurricanes, climate-related catastrophes are exposing millions of people across the world to conditions that could increase the risk of neurological disorders.

On World Brain Day, let's look at why brain health is another reason to take climate change seriously.

Effect Of Heatwaves On Brain Health

This can lead to poor concentration, slower reflexes, memory decline, headaches, confusion, and poor decision-making.

Older adults are particularly vulnerable because the brain's ability to regulate body temperature declines with age.

People living with neurological disorders like dementia, Parkinson's disease, multiple sclerosis, or epilepsy may also find that their symptoms worsen during periods of intense heat.

Also read: Will Waterborne Diseases Rise In The Future? New Study Says Climate Change Could Be A Major Driver

Effect Of Air Pollution On Brain Health

Climate change is worsening air pollution in many parts of the world by increasing wildfire smoke, ground-level ozone, and fine particulate matter.

These tiny pollutants, especially PM2.5, are small enough to enter the bloodstream and may even reach the brain. Studies have linked long-term exposure to air pollution with:

• Faster cognitive decline
• Memory impairment
• Increased risk of dementia
• Higher risk of stroke
• Parkinson's disease
• Poor brain development in children

Scientists believe air pollution may trigger chronic inflammation and oxidative stress, both of which can damage brain cells over time.

Also read: Europe Heatwave Causes 10,000 Excess Deaths; England, Wales Record 2,700 More Fatalities

Effects Of Wildfires On Brain Health

While smoke affects the lungs, it can also impact the brain.

Wildfire smoke contains fine particles and toxic chemicals that have been associated with headaches, reduced attention, poorer cognitive performance, and increased emergency visits for neurological conditions.

People with existing neurological diseases may experience worsening symptoms during periods of heavy smoke exposure.

Also read: Dangerous Heat Dome To Grip Eastern US, Canada, Putting Over 220 Million Lives At Risk: How To Stay Safe

Extreme Weather Can Accelerate Brain Ageing

Climate change is also increasing the frequency and intensity of floods, hurricanes, droughts, and other natural disasters. Beyond physical injuries, these disasters can leave lasting effects on the brain and mental health. People affected by climate disasters often experience:

• Anxiety
• Depression
• Post-traumatic stress disorder (PTSD)
• Sleep disturbances
• Chronic stress

Children, older adults, and disaster survivors are among the groups most vulnerable to these long-term psychological effects.

How To Protect Your Brain?

While tackling climate change is a long-term strategic plan, individuals can maintain few self-care habits to reduce the risks. Experts recommend:

• Staying hydrated during heatwaves
• Avoiding outdoor activity during peak afternoon heat
• Monitoring local air quality before going outside
• Wearing a well-fitting mask during heavy wildfire smoke or severe pollution
• Keeping homes cool whenever possible

Brain health is often associated with old age, but according to neurologists, the foundation for healthy cognitive function is laid much earlier.

On World Brain Day, they warned that the 30s and 40s are a crucial period to protect the brain, as lifestyle habits and underlying health conditions can quietly affect memory, concentration, and overall cognitive health.

Brain Ages Alongside the Heart

Speaking to HealthandMe, Dr. Gurucharan Adoor, Neurologist, Apollo Hospitals Bannerghatta Road, Bengaluru, said brain health is closely linked to cardiovascular health. High blood pressure, high cholesterol, and elevated blood sugar can silently damage the brain years before noticeable symptoms appear.

His advice? Make preventive health checks a routine by monitoring blood pressure, blood glucose or HbA1c, cholesterol, weight, and waist circumference—especially for people with a family history of diabetes, stroke, or early heart disease.

Brain Fog A Warning Signal

Also read: Neurological Disorders Emerging As India's Next Major Public Health Challenge, Say Experts

Dr. Adoor said sleep is often the first thing people sacrifice during their busiest years, but the brain pays the price.

Irregular sleep schedules, untreated sleep apnea, and repeated nights of poor-quality sleep can lead to mental fatigue, difficulty concentrating, and persistent brain fog. If brain fog continues, he said, it should not be ignored, as it may indicate an underlying health issue that requires attention.

Dr. Bhushan Joshi, Consultant Neurologist, Manipal Hospital, Kharadi, Pune, told HealthandMe that he is "seeing more professionals in their 30s and 40s complaining of brain fog than ever before". According to him, hormonal changes and chronic inflammation are among the common but often overlooked causes.

Hormonal Changes Can Affect Cognitive Function

Dr. Joshi noted that hormonal fluctuations can significantly influence brain function. Women entering perimenopause may experience difficulty concentrating, while others may notice "word retrieval and short-term memory due to changing estrogen levels that influence brain function."

He added that it is not limited to women. Men also undergo age-related hormonal changes that can affect energy levels and cognitive performance. While these changes are often temporary, they can still be distressing.

Read More: Aspartame, Saccharin, Erythritol Linked To Faster Brain Ageing: Study

Chronic Inflammation May Reduce Mental Clarity

Dr. Joshi explained that chronic low-grade inflammation can also contribute to brain fog. Conditions such as obesity, diabetes, autoimmune diseases, and persistent infections can trigger inflammatory responses that interfere with the brain's ability to process information efficiently. In some people, inflammation has been linked to reduced attention, poor memory, and diminished mental clarity.

Small Lifestyle Changes Key

The good news: Simple daily habits can support long-term brain health. Regular physical activity—whether it's walking, cycling, dancing, or strength training several times a week—improves blood flow to the brain, boosts mood, and supports healthy ageing.

Dr. Adoor also recommends limiting unnecessary screen time, taking regular breaks from phones and digital devices, and focusing on one task at a time to reduce mental overload.

When Should You See A Doctor?

Occasionally feeling mentally sluggish is common, but worsening memory problems or cognitive changes that begin interfering with work or daily life should not be ignored, Dr. Joshi said.

He added that these symptoms may stem from treatable conditions such as thyroid disorders, vitamin deficiencies, anxiety, or depression, making timely medical evaluation important.