We all must have come across the phase: this is why women live longer than men. These are all over the social media, where men are performing more often than not, some experiments, without gears, just for fun, "in the name of science". The caption reads: this is why women live longer. However, is there really a science to it, other than the fact that women choose to do things more safely?

In the United States, women have a life expectancy of about 80, whereas men have 75. Women outlive men and this holds true regardless of the country women live, the money they make, and other factors. In fact, it is true for most other mammals too.

Dr Dena Dubal, a professor of neurology at the University of California, San Francisco told the New York Times, "It is a very robust phenomenon all over the world, totally conserved in sickness, during famines, during epidemics, even during the times of starvation."

But what are the reasons? These reasons are often more complicated and less established. It is important to note that only because women are outliving men does not mean they are living a better life. In fact, women tend to have shorter health spans, which means the number of healthy years in a person's life is less in women than men, confirmed Bérénice Benayoun, an associate professor at the U.S.C. Leonard Davis School of Gerontology.

As per a 2021 study titled, Sex differences in frailty: Comparisons between humans and preclinical models, found that women are more physically grail than men in old age. They are also more vulnerable, especially after menopause and are at more risk of developing cardiovascular issues and Alzheimer's disease because of age.

The key is in figuring out what makes one sex more resilient or vulnerable.

Genetics

For things which do not find easy explanations, scientists look for their answers in genes. Many research, including a 2020 study titled, The sex with the reduced sex chromosome dies earlier: a comparison across the tree of life, suggests that the XX set of female sex chromosomes may impact longevity. However, there has not been any clarity on how it affects longevity.

Another 2018 study titled, Female XX sex chromosomes increase survival and extend lifespan in aging mice, which was conducted by Dr Dubal's lab, looked at genetically manipulated mice with different combinations of sex chromosomes and reproductive organs. It was found that those with two X chromosomes and ovaries lived longest, followed by mice with two X chromosomes and testes. Mice with XY chromosomes had shorter life spans.

"There was something about the second X chromosome that was protecting the mice from dying earlier in life, even if they had testes. What if there was something on that second X chromosome that was in some ways a sprinkle of the fountain of youth," says Dr Dubal. While scientists have not yet looked at this factor in humans, Dr Dubal suggests that humans have the same hormones and sex chromosomes, and similar reproductive system that could corroborate the similar findings in people.

Hormones

Plenty research has shown that estrogen is responsible for longevity also effect on the immune system. The data also shows that before menopause, the female immune system tends to do better. In fact Dr Benayoun said that males tend to do much worse in response to infection.

Another 2017 study titled, Ages at Menarche and Menopause and Reproductive Lifespan As Predictors of Exceptional Longevity in Women: The Women's Health Initiative, found that women who experienced menopause later in life over the age 50 lived longer than those who experienced it earlier.

Lifestyle and Behavior

There are also disparity in behavioral patterns between men and women. This includes smoking, drinking heavily, which can contribute significantly to mortality. Women also have more "health promoting behavior", believe experts. Women are also more likely to socialize than men and thus it protects them from detrimental effects of social isolation and loneliness. In fact, a 2023 analysis published in Jama Network, titled, Widening Gender Gap in Life Expectancy in the US, 2010-2021, found that women are less likely to die by drug overdose or suicide.

Athletes who spend years training their bodies undergo remarkable physiological changes. Athlete's heart is one of them. It becomes stronger, more efficient, and sometimes even larger. This natural adaptation is known as athlete's heart, a condition that is completely normal in most cases but can occasionally resemble serious heart disease.

What Is Athlete’s Heart?

Understanding the difference between a healthy athletic heart and an underlying cardiac disorder is crucial, especially as awareness grows around sudden cardiac deaths in young athletes.

HealthandMe spoke to Dr. Ruchit Shah, Interventional Cardiologist at Saifee Hospital, Mumbai, who said, “If a person exercises too much, normally more than 60 minutes in most days of the week for a prolonged period of time, the body's need for oxygen and for blood to supply the oxygen rises significantly. This can often be seen in the very intense training regimens of competitive athletes. The heart muscle responds to this extra demand by getting "conditioned" and thickening with time.”

Just like skeletal muscles that get bigger and thicker and with training and exercise, the heart muscle can get bigger and thicker too.

Athlete's heart is usually characterised by a “conditioned heart rate”. People with athlete's hearts will now show symptoms or serious warning signs and thereby won't need a specific treatment for the condition.

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Common Signs Of Athlete’s Heart

Signs include:

• Slow resting heart rate (bradycardia)

• Mild enlargement of the heart on imaging

• Changes on an electrocardiogram (ECG)

• High exercise capacity with no symptoms

Athlete’s Heart Is Different From Cardiac Diseases

The expert also says that athlete's heart is different from serious cardiac diseases like cardiomyopathies, especially hypertrophic obstructive cardiomyopathy (HOCM).

He says, “HOCM is a serious disease, with heart muscle thickening also occurring and causing the left ventricular cavity to narrow. The left ventricle's outflow tract can also become obstructed from this excessive thickening. Athletes with HOCM have a risk of sudden cardiac arrest and death, unlike athletes with athlete's heart.”

An athlete‘s heart, by itself, is considered a benign physiological adaptation and does not require medical intervention.

However, it becomes important to investigate further if an athlete experiences:

• Chest pain during exercise

• Unexplained fainting

• Palpitations

• Shortness of breath out of proportion to exertion

• Reduced exercise performance

• A family history of sudden cardiac death or inherited heart disease

Ignoring these warning signs can delay the diagnosis of potentially serious cardiac conditions. Those who have an athlete’s heart must get periodic cardiac evaluation, do a temporary reduction in training if the diagnosis remains uncertain, and monitor when minor abnormalities are present.

Athlete's heart is proof of the body's extraordinary ability to adapt to sustained physical activity. For most athletes, it represents a healthy, efficient cardiovascular system rather than a medical problem. The challenge lies in distinguishing these normal adaptations from potentially dangerous heart conditions that can look remarkably similar.

Adults under 40 with obesity continue to face a higher risk of cardiovascular disease than their peers with a normal Body Mass Index (BMI), according to a new study published in The Lancet.

The international study, led by researchers at Imperial College London, found that differences in blood pressure and unhealthy cholesterol levels between older adults with obesity and those with a normal BMI have narrowed—or even disappeared—in several high-income countries over the past three decades. In contrast, little or no such improvement was seen among younger adults.

Younger Adults Show No Similar Improvement

The findings suggest that adults under 40 with obesity continue to have higher blood pressure and unhealthy cholesterol levels than those with a normal BMI.

Obesity is a key risk factor for heart disease.

Researchers also found that the use of cholesterol-lowering and blood pressure medications remains low in this age group, supporting the idea that medication has played a key role in reducing cardiovascular risk among older adults.

"While good news for older adults with obesity, our results suggest that cardiovascular health risks remain higher for adults under 40 than for their counterparts with a normal BMI,” said author Ysé d'Ailhaud de Brisis, from the School of Public Health at Imperial.

"Early lifestyle interventions, screening, and, when appropriate, medication in this younger group should be considered to prevent long-term cardiovascular complications linked to obesity," de Brisis added.

Older Adults See Reduced Risk

Since the 1990s, blood pressure and unhealthy cholesterol levels have fallen more rapidly among adults aged 40 to 79 with obesity than among those with a normal BMI in most of the seven high-income countries studied, including England and the US.

The greatest improvements were seen among adults aged 60 to 79. In England and the US older adults with obesity—particularly those with severe obesity—had similar or even lower blood pressure and unhealthy cholesterol levels than those with a normal BMI by the end of the study period.

Heart Medications May Explain the Trend

The researchers said the narrowing gap is largely due to increased use of cholesterol-lowering medications, such as statins, and blood pressure medicines among adults over 40 with obesity.

For example, by the early 2020s, around 70% to 72% of older men with severe obesity in England and the US were taking cholesterol-lowering medication, compared with 40% to 48% of older men with a normal BMI.

“This latest analysis suggests that the observed convergence in cholesterol and blood pressure levels between people aged over 40 with obesity and those with a normal BMI is largely due to statins and other widely accessible medications to reduce cardiovascular risk. That is a significant public health success story, and one we should not lose sight of as new weight-loss medications enter the picture,” said author Lakshya Jain, from the School of Public Health at Imperial.

How Was the Study Conducted?

The researchers analyzed blood pressure and cholesterol data from nearly one million participants across 110 health datasets collected between 1990 and 2024.

The study included people with obesity, overweight and normal BMI from seven high-income countries: England, the US, Japan, South Korea, Taiwan, Thailand and Finland.

The authors also acknowledged limitations of the study such as, the findings may not apply to low- and middle-income countries, where access to cholesterol- and blood pressure-lowering medications is lower. Further, the study could also not assess the impact of different medication doses because prescription data were unavailable.

Popular GLP-1 medications such as Ozempic, Wegovy, and Zepbound are well established for improving metabolic health, lowering blood sugar and promoting weight loss. These blockbuster drugs are also known to reduce the risk of conditions such as heart disease and type 2 diabetes.

Now, researchers are exploring whether these medications could also help slow biological aging and potentially increase longevity.

Study Explores Anti-Aging Potential

A recent US National Institutes of Health (NIH)-backed study, published in the journal Nature, found that Ozempic slowed biological aging in people living with HIV and lipohypertrophy, a condition in which fatty deposits develop under the skin.

People with HIV often experience accelerated aging because of the infection, making them an important group for age-related research, said lead author Dr. Michael Corley, associate professor of medicine at the University of California, San Diego's Stein Institute for Research on Aging, according to The New York Times.

Although the trial was preliminary, Dr. Corley said it "provided us an opportunity to say, hey, is there any signal here that warrants all the hype?"

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Can GLP-1 Drugs Slow Aging?

Experts believe the findings are promising, but stressed that more research is needed.

Dr. Nicolas Musi, director of the Diabetes and Aging Center at Cedars-Sinai, told NYT that because these drugs reduce the risk of diseases associated with aging, they could potentially improve lifespan as well.

"GLP-1 agonists decrease the incidence of diseases that are related to aging and are associated with decreasing life span. One would assume that they're also potentially going to increase life span and be beneficial for longevity," Dr. Musi said.

Researchers also point to the drugs' anti-inflammatory effects. Chronic inflammation is one of the biological processes linked to aging, said Dr. Thomas Blackwell, professor of general internal medicine at the University of Texas Medical Branch in Galveston.

However, scientists caution that there is currently no evidence showing that GLP-1 drugs provide longevity benefits for people who are already metabolically healthy.

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What Are GLP-1 Drugs?

Drugs such as Ozempic and Wegovy contain semaglutide, a GLP-1 receptor agonist, while Zepbound and Mounjaro contain tirzepatide.

These medications are approved for the treatment of type 2 diabetes, and some are also approved for chronic weight management.

GLP-1 receptor agonists work by binding to GLP-1 receptors in the body. This increases insulin production in response to food, suppresses glucagon—a hormone that raises blood sugar—and helps regulate blood glucose levels.

What Does GLP-1 Do in the Body?

GLP-1 (glucagon-like peptide-1) is a hormone naturally produced by the small intestine after eating. It plays several important roles in regulating blood sugar and appetite by:

• Stimulating insulin release from the pancreas.
• Suppressing glucagon secretion, which helps prevent unnecessary increases in blood sugar.
• Slowing stomach emptying allows glucose to enter the bloodstream more gradually.
• Increasing feelings of fullness (satiety), which helps reduce food intake.