We all must have come across the phase: this is why women live longer than men. These are all over the social media, where men are performing more often than not, some experiments, without gears, just for fun, "in the name of science". The caption reads: this is why women live longer. However, is there really a science to it, other than the fact that women choose to do things more safely?

In the United States, women have a life expectancy of about 80, whereas men have 75. Women outlive men and this holds true regardless of the country women live, the money they make, and other factors. In fact, it is true for most other mammals too.

Dr Dena Dubal, a professor of neurology at the University of California, San Francisco told the New York Times, "It is a very robust phenomenon all over the world, totally conserved in sickness, during famines, during epidemics, even during the times of starvation."

But what are the reasons? These reasons are often more complicated and less established. It is important to note that only because women are outliving men does not mean they are living a better life. In fact, women tend to have shorter health spans, which means the number of healthy years in a person's life is less in women than men, confirmed Bérénice Benayoun, an associate professor at the U.S.C. Leonard Davis School of Gerontology.

As per a 2021 study titled, Sex differences in frailty: Comparisons between humans and preclinical models, found that women are more physically grail than men in old age. They are also more vulnerable, especially after menopause and are at more risk of developing cardiovascular issues and Alzheimer's disease because of age.

The key is in figuring out what makes one sex more resilient or vulnerable.

Genetics

For things which do not find easy explanations, scientists look for their answers in genes. Many research, including a 2020 study titled, The sex with the reduced sex chromosome dies earlier: a comparison across the tree of life, suggests that the XX set of female sex chromosomes may impact longevity. However, there has not been any clarity on how it affects longevity.

Another 2018 study titled, Female XX sex chromosomes increase survival and extend lifespan in aging mice, which was conducted by Dr Dubal's lab, looked at genetically manipulated mice with different combinations of sex chromosomes and reproductive organs. It was found that those with two X chromosomes and ovaries lived longest, followed by mice with two X chromosomes and testes. Mice with XY chromosomes had shorter life spans.

"There was something about the second X chromosome that was protecting the mice from dying earlier in life, even if they had testes. What if there was something on that second X chromosome that was in some ways a sprinkle of the fountain of youth," says Dr Dubal. While scientists have not yet looked at this factor in humans, Dr Dubal suggests that humans have the same hormones and sex chromosomes, and similar reproductive system that could corroborate the similar findings in people.

Hormones

Plenty research has shown that estrogen is responsible for longevity also effect on the immune system. The data also shows that before menopause, the female immune system tends to do better. In fact Dr Benayoun said that males tend to do much worse in response to infection.

Another 2017 study titled, Ages at Menarche and Menopause and Reproductive Lifespan As Predictors of Exceptional Longevity in Women: The Women's Health Initiative, found that women who experienced menopause later in life over the age 50 lived longer than those who experienced it earlier.

Lifestyle and Behavior

There are also disparity in behavioral patterns between men and women. This includes smoking, drinking heavily, which can contribute significantly to mortality. Women also have more "health promoting behavior", believe experts. Women are also more likely to socialize than men and thus it protects them from detrimental effects of social isolation and loneliness. In fact, a 2023 analysis published in Jama Network, titled, Widening Gender Gap in Life Expectancy in the US, 2010-2021, found that women are less likely to die by drug overdose or suicide.

Billionaire entrepreneur Bryan Johnson, known for meticulously tracking his health and pursuing longevity, recently revealed that he has been diagnosed with Autoimmune Gastritis, an incurable autoimmune condition in which the body's immune system attacks the stomach lining.

Describing the disease on social media platform X, Johnson said: "My stomach is eating itself." He also noted that despite undergoing extensive medical evaluations over the years, the condition went undetected because autoimmune diseases often develop quietly, with symptoms that can easily be mistaken for everyday health issues such as fatigue or digestive discomfort.

According to the Centers for Disease Control and Prevention (CDC), autoimmune diseases occur when the immune system mistakenly attacks the body's own healthy cells and tissues, triggering inflammation and damage to organs or other body systems.

The burden of these conditions is significant. In May 2025, researchers from the Mayo Clinic and collaborating institutions estimated that nearly 15 million Americans are living with one or more of 105 recognized autoimmune diseases.

Symptoms Can Be Easy to Miss

Because autoimmune diseases often begin with vague, non-specific symptoms, they can remain undiagnosed for months—or even years.

Dr. Cory Rice, a US-based Functional Medicine physician, said these warning signs frequently go unnoticed until the disease has progressed.

"First and foremost, symptoms of autoimmune disease can come and go, and be on and off, or they can be more persistent in nature," he told Newsweek.

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The Hidden Signs You Shouldn't Ignore

While symptoms vary depending on the various autoimmune conditions, several early warning signs are shared across many autoimmune diseases.

According to Dr. Rice, common symptoms include:

• Fatigue
• Low-grade fever
• Joint pain
• Unexplained rashes or hives
• Dry eyes and dry mouth
• Numbness or tingling in the hands or feet
• Mouth ulcers
• Increased sensitivity to cold temperatures

He said when people suffer from fatigue, "it is usually both profound and debilitating."

Dr. Rice explained that many people try to manage this overwhelming exhaustion by relying on caffeine and other stimulants, taking thyroid medications or hormone treatments, or opting for therapies such as intravenous infusions and vitamin B12 injections.

However, when an underlying autoimmune disease is responsible, these approaches often fail to provide lasting relief.

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Why Autoimmune Diseases Are Often Diagnosed Late

One of the biggest challenges in diagnosing autoimmune diseases is that their symptoms overlap with those of many other medical conditions.

Johnson also said that "2-5 per cent of people have this (autoimmune disease). Likely more, because it hides".

Symptoms may also appear intermittently before becoming more persistent.

"It all depends on the disease process in play and the severity or progression of the disease itself in a particular person as to whether symptoms are more constant or intermittent," Rice said.

He added that many primary care physicians are not routinely trained to identify autoimmune diseases in their early stages. As a result, patients are frequently referred to specialists, including rheumatologists, only after symptoms have become more pronounced.

"Unfortunately, by this point, the autoimmune disease may already be far along in whichever parts of the body are impacted," he said.

Dr. Rice emphasized that recognizing symptoms early and obtaining a timely diagnosis can help slow disease progression and improve long-term outcomes.

The United States is currently experiencing one of its worst Cyclospora outbreaks in recent years, with health officials still unable to determine the source of the infections.

According to the latest data, the outbreak has spread across at least 18 states. Michigan has reported at least 1000 cases, emerging as the hardest-hit state. With around 40 hospitalisations, no deaths have been reported so far.

Cyclospora Outbreak In The US

The outbreak is being investigated by the U.S. Centers for Disease Control and Prevention (CDC), the U.S. Food and Drug Administration (FDA), and state health departments. Investigators have not yet identified a single contaminated food source.

Several other states have also reported rising case counts. New York City has confirmed hundreds of infections since May. Health officials believe the actual number of infections is likely higher because Cyclospora is not routinely tested for in people with diarrhea. Symptoms usually begin about one week after exposure and can last weeks if untreated.

Also read: Walked Through Floodwater Recently? 5 Things To Do After Reaching Home To Minimise Risk Of Infections

About Cyclospora

A Cyclospora infection can be mild or severe and may last for weeks or even months. It is typically treated with antibiotics. People with weakened immune systems, such as those with HIV/AIDS or cancer, are at greater risk of severe disease.

Cyclospora infection commonly causes:

• Prolonged watery diarrhea
• Severe abdominal cramps
• Fatigue
• Loss of appetite
• Nausea
• Weight loss
• Bloating

Health authorities in the US continue to advise people to wash fresh produce thoroughly, maintain good hand hygiene, and seek medical care if they develop prolonged watery diarrhea, especially if symptoms persist for several days.

Does India’s Monsoon Raise Risk Of Cyclospora?

While there is no indication of a similar outbreak in India, infectious disease experts say the country's monsoon season creates conditions that can facilitate the spread of intestinal parasites if food and drinking water become contaminated.

HealthandMe spoke to Dr. Devashish Desai, Consultant, Infectious Diseases at Ruby Hall Clinic, if India, too, faces a possibility of a parasitic infection like cyclospora, especially in monsoon season.

Dr Desai said, “The answer is yes. India's monsoon creates conditions that favour the spread of several water and food-borne infections, including Cyclospora. Heavy rainfall can contaminate drinking water sources and fresh fruits and vegetables with sewage or infected soil. Consuming raw salads, unwashed herbs, or untreated water significantly increases the risk of infection.”

Unlike bacteria, cyclospora parasites require time in the environment before they become infectious, meaning direct person-to-person transmission is uncommon. Instead, contaminated food and water remain the primary sources of infection. This makes maintaining hygiene from farms to kitchens essential for prevention.

The expert added, “Although Cyclospora outbreaks are not commonly reported in India, the environmental conditions during the rainy season make vigilance essential. Strong food safety practices, clean water, and good personal hygiene remain the most effective defences against this preventable parasitic infection.”

Although India has not reported a similar outbreak, experts say the current situation in the US is a stark reminder that food safety and sanitation become even more critical during the monsoon.

For millions of people living with diabetes, the condition is not managed in moments; it is managed in the countless choices made between moments. From planning meals and staying active to monitoring glucose levels and following treatment schedules, people living with diabetes make countless decisions every day that shape their long-term health.

In clinical practice, we often see that the success of treatment is determined not only by how effective a therapy is, but also by whether it can be realistically sustained over years and decades. This is why the future of diabetes care must move beyond advancing therapies alone and focus on developing treatment approaches that are simpler, more flexible, and designed around patients' lives.

Diabetes In India: A Growing Public Health Challenge

Despite being one of the most widely recognized health conditions today, diabetes is still often misunderstood as simply a condition of “high sugar levels”. In reality, it is a metabolic disorder that develops when the body either does not produce enough insulin or is unable to use insulin effectively.

While genetic factors play an important role, rapid urbanization, sedentary lifestyles, changing dietary patterns, and rising obesity have contributed significantly to its increasing prevalence. Today, nearly 101 million adults in India are living with diabetes, according to the ICMR-INDIAB study.

Why Early And Consistent Diabetes Care Matters

With diabetes, time itself becomes a critical risk factor; the longer a person lives with the condition, the more severely it affects multiple organ systems. Diabetes can affect the heart, kidneys and nerves, with complications developing silently over several years. While improvements in the management of key cardiometabolic risk factors such as blood pressure, lipids and glycaemia have helped improve outcomes in several areas, lifestyle-related factors continue to contribute to long-term risks. This highlights the need for early risk identification, timely intervention and continuous monitoring to reduce the long-term burden of disease.

The Daily Burden Of Living With Diabetes

The progressive nature of diabetes also means that care is not limited to clinic visits; it extends into everyday life. It requires individuals to make repeated decisions throughout the day, and this constant cognitive load can become overwhelming, often leading to treatment fatigue and difficulty in maintaining consistent control.

Thus, treatment adherence is one of the strongest determinants of diabetes control. Yet real-world adherence is shaped by multiple overlapping factors. Limited understanding of the disease and its often-silent progression, along with psychological challenges such as anxiety or depression, can affect a person’s ability to remain consistent with treatment.

At the same time, complex treatment regimens, polypharmacy and the long-term burden of managing a chronic condition can make adherence more challenging. Financial constraints, limited access to medicines, and gaps in regular follow-up and patient–provider communication further add to the difficulties of sustained diabetes management.

Together, these factors contribute to poorer glycemic control, higher complication rates, increased hospitalizations and reduced quality of life.

Innovations Are Transforming Diabetes Care

Recognizing the realities of living with diabetes, care has increasingly shifted towards approaches that balance clinical effectiveness with practicality in everyday life, with greater emphasis on long-term sustainability and individual patient needs. Supporting this shift is a new generation of innovations in diabetes care that is making it more personalized, flexible and easier to manage, including:

Continuous Glucose Monitoring (CGM) has helped shift focus from HbA1c alone to include dynamic measures such as Time in Range (TIR) and glucose variability, enabling more real-time, personalized adjustments.

Oral therapies such as DPP-4 inhibitors (gliptins) and SGLT2 inhibitors (gliflozins) have expanded treatment options by helping improve glucose control while supporting more personalized and holistic diabetes management.

Newer ultra-long-acting basal insulins and ultra-rapid-acting mealtime insulins have improved glycemic stability.

Once-Weekly Insulin: A New Option For Patients

More recently, innovative solutions like once-weekly insulin icodec have been available globally that offer a simplified regimen, reduced treatment burden and improved patient adherence. This weekly insulin is now approved and launched in India for adults living with diabetes. This novel therapy could potentially reduce the practical burden of treatment and make long-term management more achievable in real-world settings.

Ultimately, the future of diabetes care will not be defined by how strictly patients follow treatment schedules, but by how well treatment fits into their lives. When care is designed around patients rather than systems, adherence becomes more natural, outcomes improve more sustainably, and diabetes management becomes less about daily struggle and more about improving the quality of life for those with diabetes.