For over 15 years, Dr Anthony Shum, a pulmonologist at the University of California, San Francisco has been studying a rare genetic disorder called the COPA Syndrome. It stands for coatomer subunit alpha and is a rare, inherited disorder that affects the lungs, joint, and kidney. The National Organization for Rare Disorder also notes that it is a genetic autoimmune disorder that is caused by mutations in the COPA gene. This disease affects families unpredictably—some individuals with the mutation develop severe lung damage early in life, while others remain completely healthy. Now, Shum’s team has discovered a protective genetic variant that may offer new hope for treatment.

A Breakthrough

Researchers found that some relatives of COPA Syndrome patients stayed healthy despite carrying the same COPA gene mutation that causes the disease. The key difference? These unaffected individuals had a protective version of another gene called HAQ-STING.

When scientists introduced HAQ-STING into diseased lung cells from COPA patients, the cells returned to a balanced state, suggesting that this gene could be used as a therapy.

“We really think HAQ-STING could be a gene therapy tool and a step toward a cure,” said Shum, whose findings were published in the Journal of Experimental Medicine.

Families Who Solved The Mystery

Shum’s journey into COPA Syndrome research began in 2011 when he treated a young woman, Letasha, who had severe lung bleeding. Her mother, Betty Towe, mentioned that Letasha’s sister, Kristina, had suffered from similar symptoms. Over the years, Betty had taken both daughters on a four-hour trip to UCSF for treatment. After tracing their family history, Shum discovered that their distant relatives in Texas and Oakland also had lung problems and arthritis. In 2015, Shum, along with scientists from Baylor College of Medicine and Texas Children’s Hospital identified the COPA gene mutation. They realized that it was the common factor behind the illness. However, only some of the 30 individuals with the mutation actually developed symptoms, leaving a major question unanswered.

The Domino Effect

It was established that it occurs when a mutated COPA gene causes another gene STING to go overdrive. The STING that helps fight infections in COPA patients, remain permanently active, which leads to chronic inflammation that damages the lungs, kidneys, and joints. In 2020, while studying STING’s role in the disease, researchers discovered a key variation: HAQ-STING. This version of STING, present in about one-third of the population, appeared to neutralize the harmful effects of the COPA mutation.

To confirm their theory, the scientists needed both affected and unaffected family members to participate in the testing. Letasha, Kristina and Betty immediately volunteered. The researchers then analyzed DNA samples from 26 COPA patients and their healthy relatives. They also conducted CT scans and blood tests to ensure that unaffected members did not have any hidden symptoms. When the findings were all clear, it was revealed that all the healthy individuals had HAQ-STING, while none of the COPA patients did. This was the first known case of a common gene variant completely protecting against a severe genetic disease.

Encouraged by this discovery, researchers tested HAQ-STING’s effects in a lab setting. They introduced it into diseased lung cells from COPA patients, and the cells returned to normal function.

Way Ahead

Shum believes HAQ-STING could lead to game-changing treatments, including:

• Prenatal gene therapy for babies diagnosed with COPA Syndrome before birth
• Aerosol delivery of HAQ-STING for adults, directly targeting the lungs

Before publishing their findings, Shum called Betty with the news—her own HAQ-STING gene had protected her from the disease. He also informed Letasha and Kristina, who were overwhelmed with relief and joy.

“We always believed Dr. Shum would get to the bottom of it,” said Letasha. “This discovery is going to change lives.”

While December arrives with celebrations, food and social gatherings, it is also the time when seasonal illnesses quietly begin to surface. Colds, lingering coughs and flu tend to spread more easily in colder weather, often catching people off guard just as the new year begins. For those hoping to avoid starting January feeling unwell, there are simple steps that can be taken ahead of time.

A pharmacist has urged people to prepare early by stocking up on essential remedies, saying that being organised can help manage symptoms quickly and reduce unnecessary visits to the doctor. According to him, early action makes winter illnesses far easier to handle.

Why Pharmacists Say Preparation Matters Before January

Pharmacists say the key to getting through winter comfortably is preparation before cold and flu season reaches its peak. Keeping a well-stocked medicine cupboard means symptoms can be treated as soon as they appear, without the stress of searching for supplies while already feeling ill.

“Preparation really is half the battle,” said pharmacist Frederick Apenteng from Roseway Labs. “Once you’re unwell, the last thing you want is to be running around looking for paracetamol or trying to buy a thermometer. That’s often when people feel worse than they need to.”

Medicines To Get Ready For Winter Flu

Frederick stresses that starting with the basics is essential. Painkillers such as paracetamol or ibuprofen help manage fever, aches and general discomfort. Throat lozenges or sprays can ease soreness, while keeping two types of cough medicine at home is helpful. One should be an expectorant for chesty coughs, and the other a suppressant for dry, irritating coughs.

The Basics Every Household Should Have

Blocked noses are another common winter complaint, and decongestants can provide quick relief. However, Frederick warns they should not be used for more than five days. For longer-term congestion, saline nasal sprays are a safer option.

Other useful items include rehydration sachets, tissues, hand sanitiser, and honey and lemon for comfort. A digital thermometer allows you to keep track of fever, while vapour rubs or a humidifier can help ease breathing when congestion strikes.

Why Nutrition and Rest Matter for Immunity

Beyond medicines, Frederick highlights the role of nutrition in keeping the immune system strong. “People often feel run down because they’re missing key nutrients,” he explained. “Iron, B vitamins and vitamin C all play important roles in supporting immune defences.”

Eating foods rich in these nutrients, such as leafy greens, citrus fruits and whole grains, can make a noticeable difference. “The biggest immunity boosters are actually sleep, proper nutrition and staying hydrated,” he added.

A Little Planning Now Can Prevent Bigger Problems Later

Preparing in advance can ease both physical discomfort and mental stress. “Having your winter kit ready means you can act quickly at the first sneeze,” Frederick said. “That can stop symptoms from getting worse and helps keep you out of the GP waiting room.”

In short, early rest, basic treatment and preparation can help people move through winter with fewer disruptions.

Be Cautious With Cold and Flu Medicines

While home remedies can be helpful, it is important not to overuse certain products. In some cases, taking too many cold and flu medicines can cause serious problems, including accidental overdose, liver or kidney damage, and rebound congestion.

Always follow dosage instructions carefully and speak to a healthcare professional if you are unsure. Frederick also cautions against prolonged use of nasal decongestant sprays. Using them for more than a few days can trigger a rebound effect, where nasal passages become more blocked than before. This condition is known as rhinitis medicamentosa.

Staying informed, prepared and cautious can make all the difference during the winter months.

If you managed to stay healthy this festive season, chances are you still know at least a couple of people who did not. In the days before Christmas and in the weeks that followed, a so-called “mystery virus” has been moving rapidly across the UK.

Many people have reported coughing, sneezing, blocked or runny noses, and in some cases stomach-related problems too. So what exactly is behind this wave of illness? Ian Budd, lead prescribing pharmacist at Chemist4U, has explained which virus is currently spreading widely across the country and what steps you can take to safeguard yourself and your family. He also sheds light on its incubation period.

What Is Adenovirus?

Adenoviruses refer to a large family of viruses that can trigger infections ranging from mild to more serious, affecting different parts of the body. Most often, adenovirus targets the respiratory tract. The symptoms can closely resemble those of a cold or flu. In the majority of cases, adenovirus infections are mild and can be managed with basic care focused on easing symptoms.

Adenovirus Incubation Period

The incubation period for adenovirus usually falls between 2 and 14 days. For many people, signs such as fever, a sore throat, or coughing tend to appear around five or six days after coming into contact with the virus, although this can differ from person to person. Adenovirus spreads easily through droplets released when someone coughs or sneezes, by touching contaminated surfaces, or through fecal-oral transmission. It is highly contagious, particularly in crowded settings, and people may continue to shed the virus even after they start feeling better, according to the National Institute of Health.

One reason the virus appears to be everywhere right now is winter behaviour. Colder weather keeps people indoors for longer periods, increasing close contact with others who may already be unwell.

Ian explained, “With COVID-19 restrictions no longer in place and fewer people being exposed to common viruses over the last few years, overall immunity in the community may be lower. That makes people more vulnerable now.

“Adenovirus itself is not new. It is simply appearing more frequently at the same time as other winter illnesses.”

Adenovirus Symptoms

If you suspect you may have adenovirus, the most common symptoms include:

• Sore throat
• Runny or blocked nose
• Cough
• Fever
• Fatigue
• Headaches or body aches
• Shortness of breath, which is less common

Other possible signs:

• Pink eye, also known as conjunctivitis, causing red, watery, gritty-feeling eyes
• Ear infections, particularly among children
• Digestive symptoms such as nausea, vomiting, or diarrhoea with certain strains

Who Do Adenoviruses Affect?

Adenoviruses can infect people at any age, but they are especially common in children under the age of five. In babies and young children, the virus often spreads in daycare settings, where close contact is unavoidable. Young children are also more likely to put shared objects in their mouths and are less consistent about handwashing.

Among adults, adenoviruses tend to spread in crowded living conditions. Those who spend time in dormitories or military housing may face a higher risk. The virus can also circulate easily in hospitals and nursing homes.

People with weakened immune systems are more likely to become seriously ill if they contract adenovirus. This group includes individuals who have undergone stem cell or organ transplants, as well as those living with cancer or HIV/AIDS. Those with existing heart or lung conditions also face a higher risk of severe infection.

Women are spending thousands of pounds to address an intimate and largely unexpected side effect linked to rapid weight loss caused by so-called “fat jabs.” As these injections grow quickly in popularity, doctors say sudden and significant weight loss is leading some women to notice changes in their labia or vulva.

This has resulted in a rise in private cosmetic procedures commonly referred to as “labia puffing.” For those unversed, the vulva refers to the external female genital area, which includes the labia. The labia are the folds of skin that surround the vaginal opening.

Weight-Loss Injections Go Mainstream

Originally developed to manage Type 2 diabetes, weight-loss injections have entered the mainstream at remarkable speed. As per Mirror, in the UK alone, about 2.5 million people are now using these drugs, according to figures reported by The Telegraph in October. That means roughly one in every 20 adults. Most users access the injections privately, as they are rarely available through the NHS. The report also noted that sales of medications such as Mounjaro and Wegovy reached 2.5 million in July, marking a sevenfold increase compared to the previous year.

While headlines have largely focused on visible changes such as slimmer bodies and faces, including among celebrities like Sharon Osbourne and Serena Williams, medical professionals say other, less discussed effects are starting to emerge.

Changes Beyond Common Side Effects

Along with widely known side effects such as nausea, diarrhoea, constipation, abdominal pain, and vomiting, some women are now reporting noticeable changes in the appearance of their vulvas and labia.

Doctors explain that the issue is not weight loss itself, but the speed at which it happens. Rapid weight loss strips fat from many areas of the body, including the vulval region. For some women, this leads to a loss of volume in the labia, causing loose or sagging skin. This can result in irritation and discomfort during everyday activities such as sitting, cycling, or exercising.

Women Share Their Experiences

Many women have taken to online forums to describe what they are experiencing. As per Mirror, one Reddit user shared, “She [the gynaecologist] told me my vulva is saggy and I will continue to experience pain when biking or sitting unless I have surgery or fillers.”

Doctors say these outcomes are not surprising. Dr Michael Tahery, writing on his women’s health website, explained that “the rapid weight loss that occurs throughout the body may result in visible sagging of the labia or vagina because of overall fat and volume loss.”

He added that this sagging can be caused by loose labia, excess skin in the vaginal area, wrinkles, or a combination of these factors. “It’s also common for rapid weight loss to cause the labia to suddenly feel out of proportion compared to how it previously felt,” he noted.

Not Just a Cosmetic Concern

For many women, the impact goes beyond appearance. The loss of natural cushioning can increase friction and sensitivity, turning once-comfortable activities into painful experiences. As a result, more women are seeking help from private clinics, where corrective procedures can cost around $2,000, or approximately £1,479. The treatment, often called labia puffing, focuses on restoring volume to the outer lips of the vulva.

What Is Labia Puffing?

Speaking to The Daily Star, Dr Shazia Malik, consultant gynaecologist at The Portland Hospital, explained how the procedure works. “Labia puffing uses dermal fillers, such as hyaluronic acid or fat, to restore volume to the labia majora, which are the outer lips of the vulva,” she said. “It is a minimally invasive procedure designed to improve appearance by increasing fullness, smoothness, and symmetry.”

Dr Malik also pointed out that the demand is not limited to women using weight-loss injections. “The procedure is most commonly sought by women who want to regain a more youthful, fuller appearance due to ageing, weight loss, or childbirth,” she explained.

A Wider Impact of Rapid Weight Loss

The growing interest in these procedures highlights how dramatically weight-loss injections can change the body. Unlike gradual weight loss achieved through diet and exercise, the speed at which fat can disappear with these drugs means changes can occur in areas people do not expect. For some women, these sudden shifts are significant enough to push them toward cosmetic interventions to feel comfortable again.