For over 15 years, Dr Anthony Shum, a pulmonologist at the University of California, San Francisco has been studying a rare genetic disorder called the COPA Syndrome. It stands for coatomer subunit alpha and is a rare, inherited disorder that affects the lungs, joint, and kidney. The National Organization for Rare Disorder also notes that it is a genetic autoimmune disorder that is caused by mutations in the COPA gene. This disease affects families unpredictably—some individuals with the mutation develop severe lung damage early in life, while others remain completely healthy. Now, Shum’s team has discovered a protective genetic variant that may offer new hope for treatment.

A Breakthrough

Researchers found that some relatives of COPA Syndrome patients stayed healthy despite carrying the same COPA gene mutation that causes the disease. The key difference? These unaffected individuals had a protective version of another gene called HAQ-STING.

When scientists introduced HAQ-STING into diseased lung cells from COPA patients, the cells returned to a balanced state, suggesting that this gene could be used as a therapy.

“We really think HAQ-STING could be a gene therapy tool and a step toward a cure,” said Shum, whose findings were published in the Journal of Experimental Medicine.

Families Who Solved The Mystery

Shum’s journey into COPA Syndrome research began in 2011 when he treated a young woman, Letasha, who had severe lung bleeding. Her mother, Betty Towe, mentioned that Letasha’s sister, Kristina, had suffered from similar symptoms. Over the years, Betty had taken both daughters on a four-hour trip to UCSF for treatment. After tracing their family history, Shum discovered that their distant relatives in Texas and Oakland also had lung problems and arthritis. In 2015, Shum, along with scientists from Baylor College of Medicine and Texas Children’s Hospital identified the COPA gene mutation. They realized that it was the common factor behind the illness. However, only some of the 30 individuals with the mutation actually developed symptoms, leaving a major question unanswered.

The Domino Effect

It was established that it occurs when a mutated COPA gene causes another gene STING to go overdrive. The STING that helps fight infections in COPA patients, remain permanently active, which leads to chronic inflammation that damages the lungs, kidneys, and joints. In 2020, while studying STING’s role in the disease, researchers discovered a key variation: HAQ-STING. This version of STING, present in about one-third of the population, appeared to neutralize the harmful effects of the COPA mutation.

To confirm their theory, the scientists needed both affected and unaffected family members to participate in the testing. Letasha, Kristina and Betty immediately volunteered. The researchers then analyzed DNA samples from 26 COPA patients and their healthy relatives. They also conducted CT scans and blood tests to ensure that unaffected members did not have any hidden symptoms. When the findings were all clear, it was revealed that all the healthy individuals had HAQ-STING, while none of the COPA patients did. This was the first known case of a common gene variant completely protecting against a severe genetic disease.

Encouraged by this discovery, researchers tested HAQ-STING’s effects in a lab setting. They introduced it into diseased lung cells from COPA patients, and the cells returned to normal function.

Way Ahead

Shum believes HAQ-STING could lead to game-changing treatments, including:

• Prenatal gene therapy for babies diagnosed with COPA Syndrome before birth
• Aerosol delivery of HAQ-STING for adults, directly targeting the lungs

Before publishing their findings, Shum called Betty with the news—her own HAQ-STING gene had protected her from the disease. He also informed Letasha and Kristina, who were overwhelmed with relief and joy.

“We always believed Dr. Shum would get to the bottom of it,” said Letasha. “This discovery is going to change lives.”

Actress Lisa Ray was diagnosed with Multiple Myeloma, an incurable but treatable blood cancer, in 2009. She successfully went into remission but experienced a cancer relapse shortly after her wedding in 2012.

During her journey to recovery, she became a prominent advocate for cancer awareness and research. However, it was during this period, at the age of 37, that she also suffered chemo-induced menopause — a topic she brushed aside, not wanting to bring it up out of shame and fear, reflecting the taboo society still associates with the natural end of a woman’s reproductive phase.

In an interaction with HealthandMe, the Oscar-nominated film Water (2005) actress opened up about her experience with chemo-induced menopause.

“I went into chemo-induced menopause at 37. I was given no support. I was completely lost. And even for a subsequent decade after that, I couldn’t find any answers. I didn’t know how to take care of myself. I didn’t know I had options,” she said.

‘I Carried This Burning Secret Inside Me’

The actress shared that she normalized many of her symptoms and avoided speaking openly about menopause despite being candid about cancer.

“I was so vocal about cancer. I’m actually somebody who prefers to be quite truthful about what I’m going through. I don’t really like to hide things. I’m not secretive by nature. And yet, I carried this burning secret inside me for so many years,” she said.

“When I was being lauded as someone who was breaking through the silence of cancer, I was carrying the silent secret inside me. I couldn’t understand why for many years. And I realized today, I was carrying shame.”

She noted that menopause continues to remain a deeply misunderstood and under-discussed subject, despite affecting all women.

‘Menopause Was Like A Black Box’

Lisa said conversations around menopause were absent even within families.

“My mother never talked to me about menopause. Of course, we discussed my period when I got it, but menopause was simply like a black box,” she said.

The actress recalled that discussions around perimenopause and menopause only began when many of her close friends started experiencing symptoms themselves.

Calling the silence around menopause “astonishing” and “extremely unjust,” Lisa said women’s hormonal health continues to be severely underfunded and misunderstood globally.

“Menopause impacts all women. Yet it’s treated like a dark secret,” she told HealthandMe.

Lisa added that once she began researching the issue, she became increasingly frustrated by the lack of awareness and medical attention surrounding menopause and hormonal health.

Menopause Not Getting Enough Attention

The actress said that after moving to Dubai, she began openly discussing menopause on social media, despite initially worrying about public reaction.

“Sometimes in social settings, women would almost shut down or turn away and say, ‘Don’t talk about that.’ But when I put it on social media, maybe it permitted a lot of other women to also find a place to have a conversation or a community,” she said.

To bring about change where women can speak freely about the topic and seek treatment early, Lisa has co-founded NuHer, a science-backed health clinic and platform dedicated to midlife care for women. It is designed to support perimenopause and menopause through personalized medical treatments, clinical psychology, and nutritional guidance.

When asked why she chose to focus on menopause and women’s hormonal health, the Four More Shots Please! actress stated, “Menopause is simply not getting the attention that it needs. Women are struggling to get the care that they need and understand their options.”

Lisa explained that while awareness around cancer has steadily improved in India since her multiple myeloma diagnosis in 2009, menopause remains “the next taboo or frontier.”

According to Lisa, NuHer aims to create a safe, science-backed space where women can access support without judgment or dismissal.

“We need a place where women can be heard, where they’re not dismissed, where they’re not gaslit, where they receive all the right science and the options they can choose for this journey,” she told HealthandMe.

She also criticized the tendency to dismiss menopausal symptoms as a “normal” part of aging without offering support or treatment options.

“Women are not broken. Menopause is not a disease like cancer that has to be cured. But women need support. We don’t need to normalize suffering,” Lisa said.

Menopause Is 'Stepping Into Our Power Age’

Speaking about aging and post-menopause life, Lisa argued that society often dismisses older women despite what she described as a biologically important phase of life.

“We’ve had terrible PR as aging women. We are dismissed and considered irrelevant when actually we’re stepping into our power age if we know how to take care of ourselves,” the acclaimed actress told HealthandMe.

However, the problem arises when menopause is left unaddressed, and the hormonal changes cause long-term health impacts, including bone health, heart disease risk, and possibly dementia.

“The problem is with the drop in hormones. If you don’t have strategies and lifestyle changes to support yourself post-menopause, you become a frail woman. Your bones suffer. You’re more prone to heart disease and possibly even dementia,” she said, urging more women to seek medical help during menopause and not suffer in silence.

GLP-1 agonist drugs like Ozempic, Mounjaro, and Wegovy, may not only help treat obesity and diabetes but also improve survival among breast cancer patients, according to a new study.

The research published in JAMA Network Open suggests that the GLP-1 agonist drugs can lower deaths in breast cancer patients as well as cut down the risk of recurrence of the deadly cancer.

Breast cancer patients who used GLP-1 RA had an overall lower risk of death from any cause over a 10-year follow-up period.

Similarly, breast cancer survivors who used GLP1-RAs for diabetes or obesity had a significantly lower risk of their cancer returning over 10 years following their initial treatment.

"This study suggests that GLP-1 drugs may offer protective benefits, potentially improving survival and recurrence risk in some female patients with breast cancer—whether this is related to weight control, improved cardiovascular health, or other mechanisms remains to be studied," said study senior author Bernard F. Fuemmeler, Chair in Cancer Research at Virginia Commonwealth University’s Massey Comprehensive Cancer Center.

The findings were based on a retrospective cohort study examining the electronic health records of more than 840,000 breast cancer patients who were diagnosed between 2006 and 2023 and also were obese or had type 2 diabetes.

GLP-1 Drugs And Breast Cancer

Also read: World Hypertension Day 2026: Why Switching Salt May Be India’s Simplest Weapon Against High Blood Pressure

Widely hailed as a medical breakthrough, the GLP-1s (glucagon-like peptide-1 receptor agonists) act like the gut hormones that regulate appetite and blood sugar.

It acts specifically on obesity and diabetes — well-established risk factors that significantly elevate the risk of breast cancer progression and recurrence.

GLP-1 medications help lower the risk of breast cancer by promoting weight loss and decreasing circulating tumor activity. It also lowers blood sugar.

Studies have showed that people taking GLP-1s also experience fewer chemo side effects. They were less likely to have anemia, blood clots in veins, low levels of white blood cells called neutrophils, low blood platelet count, sepsis, nausea and vomiting, fatigue, cardiomyopathy, and neuropathy after chemotherapy.

However, the Virginia Commonwealth University study researchers noted that further studies are needed to understand the biological mechanisms, if any, between GLP-1 RAs and breast cancer outcomes.

Global Burden of Breast Cancer

Read: High Blood Pressure? Daily Soy And Legume Intake May Help Lower The Risk: Study

Breast cancer is the most diagnosed cancer worldwide, accounting for over 2.3 million new cases annually.

According to the WHO's International Agency for Research on Cancer (IARC), it is the leading cause of cancer-related deaths among women, resulting in roughly 670,000 deaths globally each year.

It is also one of the most common cancers among women in the US, and accounts for nearly one-third of all female cancer cases.

The average risk of a woman in the US developing breast cancer sometime in her life is about 13 per cent.

Breast cancer patients who are also obese or have type 2 diabetes experience more aggressive cancer growth and worse outcomes. Prior studies have shown that weight loss treatment and surgery following a breast cancer diagnosis are associated with improved heart health and increased survival.

-Walk into any salon, and you'll be offered a facial for almost every skin concern under the sun. But somewhere along the way, targeted treatments like de-tanning started giving traditional facials a real run for their money. If your main concern is sun damage, uneven tone, or that stubborn dullness that builds up over weeks of stepping out, the de tan vs facial debate is worth having properly.

The perfect de-tan face mask used consistently at home can deliver results that genuinely rival a salon treatment. It helps you in targeting pigmentation and sun damage right at the source without the appointment, the wait, or the cost. What keeps those results going between sessions is just as important. A daily de-tan face wash helps prevent surface tan from quietly rebuilding.

So eventually your skin holds onto its progress rather than starting from scratch every week. Here's a proper breakdown of the difference between de-tan and facial so you can make the right call for your skin.

De Tan Vs Facial for Oily Skin

The core difference comes down to what each treatment is actually designed to do.

De Tan is a targeted treatment built around one primary goal. It aims to dissolve surface-level pigmentation and sun damage. It is made up of chemical exfoliants like AHAs, brightening ingredients like vitamin C or kojic acid, and clay formulas that peel away tanned, dead skin cells to expose younger skin underneath.

A facial is a multi-step ritual that addresses overall skin health, not just one specific condition. It usually comprises cleansing, exfoliating, steaming, extraction, massage, and masks. Each phase has a particular objective. A facial is a great way to boost circulation, tackle a range of skin issues all at once, and give your skin a really good refresh.

Maintaining De-Tan Results at Home: A Wiser Approach

Including a targeted de-tan mask in the weekly regimen can help those who want to keep their skin more even-toned and brighter in between salon visits. Exfoliating acids, oil-balancing clays, and barrier-supporting elements fuel a product that targets dullness, uneven texture, and stubborn tan without stripping the skin.

Products like the Foxtale Skin Radiance De-Tan Mask are particularly helpful for oily, mixed, and sun-exposed skin types since they combine light exfoliation with skin-brightening treatment. Over time, a de-tan treatment at home may make skin seem brighter, fresher, and more radiant when used regularly in conjunction with daily sunscreen.

Which One Suits Your Skin Type?

Oily & Acne-Prone Skin

For oily and acne-prone skin, a targeted de-tan treatment is almost always the safer choice over a traditional facial. Most salon facials designed for brightening use heavy cream-based products, facial massages with oils, and steam, all of which can aggravate acne, clog pores, and trigger fresh breakouts on skin that's already overproducing sebum.

When you use a detan mask with Kaolin Clay and AHAs, it controls excess oil and pigmentation. It does all this without introducing anything that worsens breakouts for you. If you have oily skin, at-home detan treatments done consistently outperform most salon facials in both safety and visible results.

Dry & Dehydrated Skin

A traditional facial that includes a hydrating massage and a nourishing mask can work well here because it addresses moisture levels alongside surface concerns.

That said, a detan treatment isn't off the table for dry skin. The key is picking the right formula, one that uses gentler AHAs like Lactic Acid rather than stronger Glycolic Acid, and that includes hydrating ingredients like Ceramides or Hyaluronic Acid to counterbalance the exfoliation.

Dull & Sun-Damaged Skin

When the skin is suffering from a noticeable tan, uneven tone, and stubborn dullness from sun exposure, a detan treatment is the gold standard of 2026. A facial can provide a glow to your overall tone, but it doesn’t target the melanin deposit that produces your tan and pigmentation. A detan mask with Glycolic Acid, Niacinamide, and brightening clays works on the actual source of the problem, and with consistent use, the results compound over time in a way that a monthly salon facial simply can't replicate.

Which Works Better for Pigmentation and Sun Damage?

Here's a simple way in which you can decide:

Choose a De-Tan when:

• Your main concern is tan, uneven skin tone, or post-sun pigmentation
• You prefer to have targeted, efficient results at home without salon visits
• Your skin is oily or acne-prone and reacts badly to heavy facial products
• You need something you can do consistently every week as part of your routine
• You've just come back from a trip, a wedding season, or an extended time outdoors, and need to reset your skin quickly.

Choose a Facial when:

• Your skin needs an overall reset, not just brightening, but deep cleansing, circulation boost, and hydration together
• You're dealing with multiple concerns at once and want a professional to assess and treat your skin
• Your skin is dry or mature, and benefits from the massage and nourishment steps a facial includes
• You want a one-time intensive treatment before a special occasion rather than an ongoing routine fix.

For most people, the best approach isn't choosing one over the other permanently. In fact, you should understand when each serves your skin best and use them accordingly. A weekly de-tan treatment at home, with an occasional facial when your skin needs a deeper reset, covers most bases without overcomplicating your routine.

Can You Use a De-Tan Mask Instead of a Facial?

The facial vs de-tan debate doesn't have a single winner. It actually depends entirely on what your skin is dealing with and what goal you are trying to achieve. If you have issues with tan, pigmentation, and sun damage, a dedicated detan treatment is a better option for you.

Overall skin health, hydration, and multi-concern maintenance are where a facial earns its place. Know what your skin needs, pick the right tool for the job, and stay consistent; that's where the real results come from.