For over 15 years, Dr Anthony Shum, a pulmonologist at the University of California, San Francisco has been studying a rare genetic disorder called the COPA Syndrome. It stands for coatomer subunit alpha and is a rare, inherited disorder that affects the lungs, joint, and kidney. The National Organization for Rare Disorder also notes that it is a genetic autoimmune disorder that is caused by mutations in the COPA gene. This disease affects families unpredictably—some individuals with the mutation develop severe lung damage early in life, while others remain completely healthy. Now, Shum’s team has discovered a protective genetic variant that may offer new hope for treatment.

A Breakthrough

Researchers found that some relatives of COPA Syndrome patients stayed healthy despite carrying the same COPA gene mutation that causes the disease. The key difference? These unaffected individuals had a protective version of another gene called HAQ-STING.

When scientists introduced HAQ-STING into diseased lung cells from COPA patients, the cells returned to a balanced state, suggesting that this gene could be used as a therapy.

“We really think HAQ-STING could be a gene therapy tool and a step toward a cure,” said Shum, whose findings were published in the Journal of Experimental Medicine.

Families Who Solved The Mystery

Shum’s journey into COPA Syndrome research began in 2011 when he treated a young woman, Letasha, who had severe lung bleeding. Her mother, Betty Towe, mentioned that Letasha’s sister, Kristina, had suffered from similar symptoms. Over the years, Betty had taken both daughters on a four-hour trip to UCSF for treatment. After tracing their family history, Shum discovered that their distant relatives in Texas and Oakland also had lung problems and arthritis. In 2015, Shum, along with scientists from Baylor College of Medicine and Texas Children’s Hospital identified the COPA gene mutation. They realized that it was the common factor behind the illness. However, only some of the 30 individuals with the mutation actually developed symptoms, leaving a major question unanswered.

The Domino Effect

It was established that it occurs when a mutated COPA gene causes another gene STING to go overdrive. The STING that helps fight infections in COPA patients, remain permanently active, which leads to chronic inflammation that damages the lungs, kidneys, and joints. In 2020, while studying STING’s role in the disease, researchers discovered a key variation: HAQ-STING. This version of STING, present in about one-third of the population, appeared to neutralize the harmful effects of the COPA mutation.

To confirm their theory, the scientists needed both affected and unaffected family members to participate in the testing. Letasha, Kristina and Betty immediately volunteered. The researchers then analyzed DNA samples from 26 COPA patients and their healthy relatives. They also conducted CT scans and blood tests to ensure that unaffected members did not have any hidden symptoms. When the findings were all clear, it was revealed that all the healthy individuals had HAQ-STING, while none of the COPA patients did. This was the first known case of a common gene variant completely protecting against a severe genetic disease.

Encouraged by this discovery, researchers tested HAQ-STING’s effects in a lab setting. They introduced it into diseased lung cells from COPA patients, and the cells returned to normal function.

Way Ahead

Shum believes HAQ-STING could lead to game-changing treatments, including:

• Prenatal gene therapy for babies diagnosed with COPA Syndrome before birth
• Aerosol delivery of HAQ-STING for adults, directly targeting the lungs

Before publishing their findings, Shum called Betty with the news—her own HAQ-STING gene had protected her from the disease. He also informed Letasha and Kristina, who were overwhelmed with relief and joy.

“We always believed Dr. Shum would get to the bottom of it,” said Letasha. “This discovery is going to change lives.”

Delhi, on Wednesday morning, woke up to 'very poor' air. The visibility was low and, in fact, the India Meteorological Department (IMD) issued an orange alert for dense fog between 8.30am and 10am. Visibility remained low, and as per the 24-hour average Air Quality Index, Delhi stood at 384, as confirmed by the data from the Central Pollution Control Board (CPCB). In certain areas, including Anand Vihar, AQI remained under 'severe' level, at 452.

This has resulted in cancellation of t least 148 flights and over 150 flights were delayed at the Delhi airport.

However, there may be a silver lining, in an interview with TOI, Tarun Kumar Pithode, who took charge as the new full-time member secretary of the Commission for Air Quality Management (CAQM) said that Delhi can expect "more blue-sky days over next 3-4 years".

How Does The Commission for Air Quality Management Plan To Bring Delhi's Pollution Down?

Delhi’s fight against air pollution is set to intensify over the next few years, with the CAQM outlining a multi-pronged plan aimed at delivering “more blue-sky days” for the capital. Rather than relying on emergency measures alone, the strategy focuses on long-term, structural fixes across transport, industry, energy and regional coordination.

Cutting Emissions at the Source

One of CAQM’s core priorities is reducing pollution from vehicles, which remain a major contributor to Delhi’s poor air quality. The plan pushes for faster adoption of electric vehicles, tighter checks on polluting commercial vehicles, and a stronger public transport network. Scrapping old, high-emission vehicles and discouraging diesel use through stricter enforcement are seen as key steps to curb everyday emissions, not just during winter spikes.

Cleaning Up Industry and Power Generation

Industrial pollution is another major target. CAQM has stressed a shift away from coal and other dirty fuels toward cleaner energy sources. Industries operating in and around Delhi are being pushed to adopt cleaner fuels such as natural gas, along with better emission-control technologies. Power plants in the region are also under scrutiny, with stricter norms to ensure they do not become pollution hotspots during peak winter months.

Tackling Dust and Construction Pollution

Construction dust and road dust significantly worsen Delhi’s air quality, especially during dry months. CAQM’s plan includes stricter enforcement of dust-control norms at construction sites, better mechanised road sweeping, and regular water sprinkling on major roads. Authorities are also being asked to improve urban planning to reduce exposed soil and unpaved areas that contribute to dust pollution.

Managing Seasonal Pollution and Stubble Burning

A major part of Delhi’s pollution problem comes from outside the city, particularly crop residue burning in neighboring states. CAQM has emphasized regional coordination, working with states like Punjab, Haryana and Uttar Pradesh to reduce stubble burning. This includes promoting alternative methods for crop residue management, providing financial incentives, and ensuring accountability when violations occur.

Data-Driven and Year-Round Action

Unlike earlier approaches that focused largely on winter emergencies, CAQM’s plan relies on year-round monitoring and data-driven action. Expanded air-quality monitoring, better forecasting, and early interventions are expected to prevent pollution levels from spiralling out of control. The aim is to move from reactive crisis management to consistent prevention.

A Long Road Ahead

CAQM officials acknowledge that Delhi’s pollution problem will not disappear overnight. However, with coordinated action across sectors and states, they believe the capital can see steady improvement over the next three to four years. The promise of more blue-sky days hinges not just on policy, but on strict enforcement and sustained public cooperation.

"There is a big mistake you are making when you fly and no one talks about how to prevent it," writes Dr Rema Malik, a board-certified vascular surgeon, based in Houston, Texas. On her Instagram post she talks about how our body deals with much of a serious challenge once we enter the plane and the cabin doors shut. She points out that while most of us are busy settling into our seats, our veins enter a risky environment that could raise the chance of developing a blood clot. These risks include deep vein thrombosis or DVT. She points out that this risk is not just limited to older adults, but to people with known health issues too.

What Really Happens to Your Body Mid-Flight

Dr. Malik explains that air travel creates what she calls a “three-hit combo” that puts your circulation under stress.

First is prolonged sitting. When you stay seated for hours, your calf muscles, often called your second heart, stop doing their job. These muscles help push blood back up toward the heart. Without movement, blood begins to pool in the legs instead of flowing upward.

Second comes dehydration. Cabin air is extremely dry, far drier than most natural environments. This causes your body to lose moisture faster than you realize. As dehydration sets in, your blood becomes thicker and more sluggish, which makes clot formation easier.

The third factor is cabin pressure. Lower pressure at cruising altitude causes veins to dilate or expand. This stretching weakens the tiny valves inside your veins that normally prevent blood from flowing backward. Gravity then does the rest, encouraging blood to settle in the lower limbs.

This combination is not about discomfort. It is about safety.

Read: Not Boarded Any Flight And Still Monday Feels Like A Jetlag? You Are Not Alone

Why Age Is Not the Only Risk Factor

There is a common belief that blood clots only affect the elderly or people with chronic illnesses. Dr. Malik strongly disagrees. Whether you are 25 or 65, long flights place similar stress on your circulation. Sitting still, dehydration, and pressure changes affect everyone, regardless of how fit or young they feel.

That is why she recommends preparing your body for travel just as seriously as you prepare your suitcase.

Wear the Right Protection Before You Fly

Compression socks are not just for people with medical conditions. Dr. Malik calls them non-negotiable for air travel. A compression level of 15 to 20 mmHg helps mechanically push blood upward, prevents swelling, and supports healthy circulation.

The key is timing. Put them on before you leave home, not after you board the plane, so your veins are supported from the very start.

Hydration Is a Flight Essential

Her rule is simple. Drink eight ounces of water for every hour you are in the air. This helps keep your blood from becoming too thick.

Coffee, alcohol, and wine do not count. In fact, they make dehydration worse. If you are serious about flying safely, water needs to be your main beverage.

Keep Your Calf Muscles Active

Every 30 minutes, Dr. Malik recommends doing 30 ankle pumps. Lift your toes up and down as if you are pressing a gas pedal. This simple movement activates your calf muscles and helps clear stagnant blood from your legs, even if you cannot get up and walk.

While December arrives with celebrations, food and social gatherings, it is also the time when seasonal illnesses quietly begin to surface. Colds, lingering coughs and flu tend to spread more easily in colder weather, often catching people off guard just as the new year begins. For those hoping to avoid starting January feeling unwell, there are simple steps that can be taken ahead of time.

A pharmacist has urged people to prepare early by stocking up on essential remedies, saying that being organised can help manage symptoms quickly and reduce unnecessary visits to the doctor. According to him, early action makes winter illnesses far easier to handle.

Why Pharmacists Say Preparation Matters Before January

Pharmacists say the key to getting through winter comfortably is preparation before cold and flu season reaches its peak. Keeping a well-stocked medicine cupboard means symptoms can be treated as soon as they appear, without the stress of searching for supplies while already feeling ill.

“Preparation really is half the battle,” said pharmacist Frederick Apenteng from Roseway Labs. “Once you’re unwell, the last thing you want is to be running around looking for paracetamol or trying to buy a thermometer. That’s often when people feel worse than they need to.”

Medicines To Get Ready For Winter Flu

Frederick stresses that starting with the basics is essential. Painkillers such as paracetamol or ibuprofen help manage fever, aches and general discomfort. Throat lozenges or sprays can ease soreness, while keeping two types of cough medicine at home is helpful. One should be an expectorant for chesty coughs, and the other a suppressant for dry, irritating coughs.

The Basics Every Household Should Have

Blocked noses are another common winter complaint, and decongestants can provide quick relief. However, Frederick warns they should not be used for more than five days. For longer-term congestion, saline nasal sprays are a safer option.

Other useful items include rehydration sachets, tissues, hand sanitiser, and honey and lemon for comfort. A digital thermometer allows you to keep track of fever, while vapour rubs or a humidifier can help ease breathing when congestion strikes.

Why Nutrition and Rest Matter for Immunity

Beyond medicines, Frederick highlights the role of nutrition in keeping the immune system strong. “People often feel run down because they’re missing key nutrients,” he explained. “Iron, B vitamins and vitamin C all play important roles in supporting immune defences.”

Eating foods rich in these nutrients, such as leafy greens, citrus fruits and whole grains, can make a noticeable difference. “The biggest immunity boosters are actually sleep, proper nutrition and staying hydrated,” he added.

A Little Planning Now Can Prevent Bigger Problems Later

Preparing in advance can ease both physical discomfort and mental stress. “Having your winter kit ready means you can act quickly at the first sneeze,” Frederick said. “That can stop symptoms from getting worse and helps keep you out of the GP waiting room.”

In short, early rest, basic treatment and preparation can help people move through winter with fewer disruptions.

Be Cautious With Cold and Flu Medicines

While home remedies can be helpful, it is important not to overuse certain products. In some cases, taking too many cold and flu medicines can cause serious problems, including accidental overdose, liver or kidney damage, and rebound congestion.

Always follow dosage instructions carefully and speak to a healthcare professional if you are unsure. Frederick also cautions against prolonged use of nasal decongestant sprays. Using them for more than a few days can trigger a rebound effect, where nasal passages become more blocked than before. This condition is known as rhinitis medicamentosa.

Staying informed, prepared and cautious can make all the difference during the winter months.