For over 15 years, Dr Anthony Shum, a pulmonologist at the University of California, San Francisco has been studying a rare genetic disorder called the COPA Syndrome. It stands for coatomer subunit alpha and is a rare, inherited disorder that affects the lungs, joint, and kidney. The National Organization for Rare Disorder also notes that it is a genetic autoimmune disorder that is caused by mutations in the COPA gene. This disease affects families unpredictably—some individuals with the mutation develop severe lung damage early in life, while others remain completely healthy. Now, Shum’s team has discovered a protective genetic variant that may offer new hope for treatment.

A Breakthrough

Researchers found that some relatives of COPA Syndrome patients stayed healthy despite carrying the same COPA gene mutation that causes the disease. The key difference? These unaffected individuals had a protective version of another gene called HAQ-STING.

When scientists introduced HAQ-STING into diseased lung cells from COPA patients, the cells returned to a balanced state, suggesting that this gene could be used as a therapy.

“We really think HAQ-STING could be a gene therapy tool and a step toward a cure,” said Shum, whose findings were published in the Journal of Experimental Medicine.

Families Who Solved The Mystery

Shum’s journey into COPA Syndrome research began in 2011 when he treated a young woman, Letasha, who had severe lung bleeding. Her mother, Betty Towe, mentioned that Letasha’s sister, Kristina, had suffered from similar symptoms. Over the years, Betty had taken both daughters on a four-hour trip to UCSF for treatment. After tracing their family history, Shum discovered that their distant relatives in Texas and Oakland also had lung problems and arthritis. In 2015, Shum, along with scientists from Baylor College of Medicine and Texas Children’s Hospital identified the COPA gene mutation. They realized that it was the common factor behind the illness. However, only some of the 30 individuals with the mutation actually developed symptoms, leaving a major question unanswered.

The Domino Effect

It was established that it occurs when a mutated COPA gene causes another gene STING to go overdrive. The STING that helps fight infections in COPA patients, remain permanently active, which leads to chronic inflammation that damages the lungs, kidneys, and joints. In 2020, while studying STING’s role in the disease, researchers discovered a key variation: HAQ-STING. This version of STING, present in about one-third of the population, appeared to neutralize the harmful effects of the COPA mutation.

To confirm their theory, the scientists needed both affected and unaffected family members to participate in the testing. Letasha, Kristina and Betty immediately volunteered. The researchers then analyzed DNA samples from 26 COPA patients and their healthy relatives. They also conducted CT scans and blood tests to ensure that unaffected members did not have any hidden symptoms. When the findings were all clear, it was revealed that all the healthy individuals had HAQ-STING, while none of the COPA patients did. This was the first known case of a common gene variant completely protecting against a severe genetic disease.

Encouraged by this discovery, researchers tested HAQ-STING’s effects in a lab setting. They introduced it into diseased lung cells from COPA patients, and the cells returned to normal function.

Way Ahead

Shum believes HAQ-STING could lead to game-changing treatments, including:

• Prenatal gene therapy for babies diagnosed with COPA Syndrome before birth
• Aerosol delivery of HAQ-STING for adults, directly targeting the lungs

Before publishing their findings, Shum called Betty with the news—her own HAQ-STING gene had protected her from the disease. He also informed Letasha and Kristina, who were overwhelmed with relief and joy.

“We always believed Dr. Shum would get to the bottom of it,” said Letasha. “This discovery is going to change lives.”

While entrepreneurs debate 70-hour workweeks and professionals continue to slog through long working hours under relentless productivity pressures, basic health needs often take a back seat. The consequences may not be immediately visible, but the body's vital organs quietly bear the burden.

Among them, the kidneys are particularly vulnerable. Poor hydration, irregular eating habits, excessive caffeine intake, lack of sleep, and chronic stress can gradually damage kidney function without causing noticeable symptoms, potentially leading to serious health consequences over time, said experts on the occasion of World Kidney Cancer Day 2026.

World Kidney Cancer Day is observed annually on the third Thursday of June. Spearheaded by the International Kidney Cancer Coalition, the day raises global awareness about the disease, highlights risk factors, and advocates for early detection and patient support.

Also read: Trying to Quit Tobacco? Yoga Could Improve Your Chances, Suggests Study

How Modern Work Culture Is Harming Kidney Health

The kidneys play a vital role in filtering waste from the blood, regulating blood pressure, maintaining fluid balance, and supporting overall metabolic function.

Speaking to HealthandMe, Dr. L K Jha, Principal Director – Nephrology & Renal Transplant at Yashoda Medicity, pointed out habits such as eating out frequently, inadequate hydration, excessive caffeine consumption, insufficient sleep, and chronic stress that have become routine parts of the workday.

While these behaviors may seem manageable in the short term, they can have significant consequences for kidney health over time. They are also associated with an increased risk of hypertension, obesity, and diabetes, conditions that can gradually impair kidney function. These are also the primary drivers of chronic kidney disease and a significant risk factor for certain kidney cancers.

Dr. Jha emphasized that "kidney diseases are particularly concerning because they often remain asymptomatic until substantial damage has already occurred."

He noted that prioritizing hydration, routine health checkups, regular physical activity, and stress reduction is not only important for maintaining good health but also an investment in long-term well-being and workplace performance.

Kidney Diseases Often Progress Silently

Dr. Saurabh Shukla, Senior Consultant – Nephrology at Paras Health Gurugram, told HealthandMe that the "fast-paced corporate culture is inadvertently contributing to a growing health crisis, with kidney health emerging as one of its major casualties."

He pointed out that kidney-related conditions often progress silently, with few warning signs appearing until serious damage has occurred. Long hours spent sitting, constant workplace pressure, irregular meal schedules, and dependence on caffeine rather than water are quietly affecting the health of working professionals.

He also highlighted habitual dehydration, high-sodium processed foods, and delayed medical checkups as additional concerns.

Early Detection Is Key

From a clinical perspective, Dr. Shukla stressed that early detection is crucial.

"While symptoms such as blood in the urine, persistent lower back pain, unexplained fatigue, or swelling in the legs require prompt medical attention, many kidney conditions are identified incidentally during routine screenings," he said.

Simple Lifestyle Changes

The experts underscored that protecting kidney health does not necessarily require drastic lifestyle changes. They suggested simple measures such as:

• Staying adequately hydrated
• Reducing consumption of processed foods
• Remaining physically active
• Undergoing regular health screenings

Dr. Shukla also emphasized the role of employers, suggesting that corporations should implement wellness programs that encourage healthier habits among employees.

In high-stress work environments, he noted, prioritizing kidney health is becoming increasingly important.

Men often carry the responsibility for their families. They work hard and manage professional pressures to provide the best for their loved ones. Yet, many men tend to neglect their own health, the one thing that makes everything else possible.

Across age groups, men often seek medical attention only when the problem becomes severe or when symptoms become impossible to ignore. The most unfortunate thing regarding health is that many health conditions develop silently for years before showing signs. Taking care of yourselves is not selfish; it is essential. After all, the healthier you are, the better equipped you are to support your family, pursue your goals, and enjoy a fulfilling life for years to come.

Prioritize Preventive Health Checkups

One of the best ways to keep an eye on your health is by scheduling regular health screenings. Many conditions, including High BP, Diabetes, high cholesterol, liver disease, and kidney disorders, may not cause noticeable symptoms in the early stages. Annual health checkups can help identify potential problems way before they become serious.

Depending on age and family history, men should also discuss appropriate cancer screenings. Early detection leads to simpler treatment and better outcomes. Make preventive health checkups a routine. Just as a vehicle performs better with regular servicing, your body also needs regular monitoring.

Muscle Mass Is The Key

Maintaining muscle mass is equally important for men as they age. Muscle plays a vital role in supporting metabolism. Even though it is important for improving insulin sensitivity, protecting bone health, and maintaining strength. You don’t need rigorous exercise daily.

Strength training two to four days a week is sufficient. It may also help support healthy testosterone levels and reduce the risk of chronic conditions like type 2 diabetes and heart disease. The best thing is that strength training doesn’t require spending hours in a gym. Consistency matters far more than perfection.

Sound Mind For A Sound Body

We often say that ‘sound mind in a sound body’. This is even true vice versa. Many men feel pressure to appear strong all the time, which can make things difficult. Stress, anxiety, and depression can affect anyone. Persistent fatigue, irritability, difficulty concentrating, or disrupted sleep may be warning signs.

Keep an eye on such changes. Discussion is not a sign of weakness. Talk to trusted family members, friends, or mental health professionals. It can make a significant difference.

Sleep Is The Real Game-Changer

Quality sleep is one of the most powerful tools for maintaining good health. Generally, adults need between seven and nine hours of sleep each night. It helps the body to repair tissues, regulates hormones, and supports brain function.

Poor sleep is linked to weight gain, increased stress, and weakened immune function. If your morning is often tiring or you are struggling with insomnia, then discuss it with your healthcare professional. Limit screen time before bed and avoid excessive caffeine late in the day. It can help improve sleep quality.

Take Heart Health Seriously

Heart disease remains one of the leading health risks for men worldwide. The good news is that many cardiovascular risk factors are largely preventable. A healthy weight, physical activity, and a balanced diet can significantly improve heart health.

Avoiding tobacco products and limiting alcohol consumption is also helpful. Add vegetables, fruits, lean proteins, whole grains, and healthy fats to your daily diet. Such a diet can support both heart and overall well-being. Daily brisk walk can help improve BP, cholesterol levels, and cardiovascular fitness.

(By Dr Shivam Sharma, Internal Medicine, Shalby International Hospitals, Gurugram)

Fever is one of the body's most common warning signals. In most cases, particularly among children, it is caused by a simple infection and resolves within a few days. However, when fever keeps returning repeatedly, follows a pattern, or occurs alongside other concerning symptoms, it may signal an underlying health condition that requires medical attention.

What Is A Recurring Fever?

Dr. Hemalata Arora, Director of Internal Medicine at Nanavati Max Super Speciality Hospital, Mumbai, told HealthandMe that a recurring fever refers to repeated episodes of elevated body temperature that are separated by days, weeks, or even months during which a person feels completely well.

While recurrent fevers can sometimes result from common viral infections, especially in children exposed to school environments, daycare settings, or seasonal illnesses, persistent or unexplained episodes warrant further investigation.

The expert stated that understanding the pattern of fever is often one of the most important clues in determining the cause.

What Can Cause Recurring Fever?

Dr. Diksha Goyal, Consultant in Internal Medicine at Marengo Asia Hospitals, Gurugram, told HealthandMe that a recurrent fever can occur when body temperature rises to 38°C or higher and reappears after improving or occurs intermittently over time.

Several medical conditions may cause recurring fever, including:

1. Chronic Infections such as tuberculosis (TB), urinary tract infections

2. Autoimmune Diseases

3. Immune System Disorders

4. Cancers, particularly blood-related cancers

5. Certain Viral Infections

Also read: Doctors Call Kratom The ‘Next Addiction Crisis’ As More US States Push Bans

Warning Signs That Should Not Be Ignored

While recurrent fever is not always dangerous, the experts emphasize that certain accompanying symptoms require prompt medical evaluation.

Dr. Arora notes that urgent attention is needed if recurring fever is associated with:

• Unexplained weight loss
• Night sweats
• Persistent fatigue or unusual tiredness
• Poor appetite
• Repeated vomiting
• Breathing difficulties
• Persistent abdominal pain
• Confusion or altered mental status

Dr. Goyal added that persistent cough, swollen lymph nodes, and unexplained body pain can also indicate an underlying condition requiring medical treatment.

These symptoms may point toward serious infections, immune system disorders, blood-related diseases, cancers, or inflammatory conditions in which the body's defense system triggers repeated inflammation without a clear infection.

Early Treatment For Better Outcomes

Another important warning sign is a fever that continues to recur despite treatment. According to Dr. Arora, repeated courses of antibiotics without a confirmed diagnosis should raise concern. In some cases, medications themselves can trigger fever, making a detailed medication history an important part of the evaluation.

The goal is not to panic but to seek timely medical assessment. Check for swollen lymph nodes, rashes, signs of infection, or evidence of systemic inflammation.

The experts noted that early medical evaluation can help identify the underlying cause, prevent complications, and ensure appropriate treatment. With timely diagnosis and proper management, many causes of recurrent fever can be effectively treated, allowing individuals to maintain their health and daily activities.