For over 15 years, Dr Anthony Shum, a pulmonologist at the University of California, San Francisco has been studying a rare genetic disorder called the COPA Syndrome. It stands for coatomer subunit alpha and is a rare, inherited disorder that affects the lungs, joint, and kidney. The National Organization for Rare Disorder also notes that it is a genetic autoimmune disorder that is caused by mutations in the COPA gene. This disease affects families unpredictably—some individuals with the mutation develop severe lung damage early in life, while others remain completely healthy. Now, Shum’s team has discovered a protective genetic variant that may offer new hope for treatment.

A Breakthrough

Researchers found that some relatives of COPA Syndrome patients stayed healthy despite carrying the same COPA gene mutation that causes the disease. The key difference? These unaffected individuals had a protective version of another gene called HAQ-STING.

When scientists introduced HAQ-STING into diseased lung cells from COPA patients, the cells returned to a balanced state, suggesting that this gene could be used as a therapy.

“We really think HAQ-STING could be a gene therapy tool and a step toward a cure,” said Shum, whose findings were published in the Journal of Experimental Medicine.

Families Who Solved The Mystery

Shum’s journey into COPA Syndrome research began in 2011 when he treated a young woman, Letasha, who had severe lung bleeding. Her mother, Betty Towe, mentioned that Letasha’s sister, Kristina, had suffered from similar symptoms. Over the years, Betty had taken both daughters on a four-hour trip to UCSF for treatment. After tracing their family history, Shum discovered that their distant relatives in Texas and Oakland also had lung problems and arthritis. In 2015, Shum, along with scientists from Baylor College of Medicine and Texas Children’s Hospital identified the COPA gene mutation. They realized that it was the common factor behind the illness. However, only some of the 30 individuals with the mutation actually developed symptoms, leaving a major question unanswered.

The Domino Effect

It was established that it occurs when a mutated COPA gene causes another gene STING to go overdrive. The STING that helps fight infections in COPA patients, remain permanently active, which leads to chronic inflammation that damages the lungs, kidneys, and joints. In 2020, while studying STING’s role in the disease, researchers discovered a key variation: HAQ-STING. This version of STING, present in about one-third of the population, appeared to neutralize the harmful effects of the COPA mutation.

To confirm their theory, the scientists needed both affected and unaffected family members to participate in the testing. Letasha, Kristina and Betty immediately volunteered. The researchers then analyzed DNA samples from 26 COPA patients and their healthy relatives. They also conducted CT scans and blood tests to ensure that unaffected members did not have any hidden symptoms. When the findings were all clear, it was revealed that all the healthy individuals had HAQ-STING, while none of the COPA patients did. This was the first known case of a common gene variant completely protecting against a severe genetic disease.

Encouraged by this discovery, researchers tested HAQ-STING’s effects in a lab setting. They introduced it into diseased lung cells from COPA patients, and the cells returned to normal function.

Way Ahead

Shum believes HAQ-STING could lead to game-changing treatments, including:

• Prenatal gene therapy for babies diagnosed with COPA Syndrome before birth
• Aerosol delivery of HAQ-STING for adults, directly targeting the lungs

Before publishing their findings, Shum called Betty with the news—her own HAQ-STING gene had protected her from the disease. He also informed Letasha and Kristina, who were overwhelmed with relief and joy.

“We always believed Dr. Shum would get to the bottom of it,” said Letasha. “This discovery is going to change lives.”

India is in the peak of summer, with heatwave conditions affecting several parts of the country. The India Meteorological Department (IMD) has predicted that these extreme heat conditions will continue over the next few days, especially across North and Central India.

According to IMD's latest bulletin, heat wave conditions are likely in isolated pockets of Bihar, Haryana-Chandigarh-Delhi, Punjab, East Rajasthan, Vidarbha, Chhattisgarh, and Jharkhand.

The IMD has also forecast a yellow alert for heatwave conditions at isolated places in Delhi from today, with maximum temperatures expected to climb between 41 °C and 44 °C through April 24. The state government has issued guidelines for all schools, focusing on hydration and safety measures.

As temperatures rise, health experts highlighted the disproportionate burden of heat on women and the related physical, social, and financial effects. Studies show women often have higher heat-related mortality rates and suffer from increased fatigue, dehydration, and reproductive health issues.

Women typically face higher risks during heatwaves than men due to

• physiological factors (higher body fat, lower sweat rate),
• hormonal changes (menopause, pregnancy),
• social roles.

How Heatwaves Affect Women Differently

Heat stress is known to interfere with the endocrine system, which disrupts hormonal balance. This means that severe heat can cause delay or interrupt menstrual cycles, causing heavier or more painful periods, and, in severe cases, absence of menstruation. Women with conditions like PCOS or endometriosis face compounded stress.

"Many women report feeling unusually tired, irritable, or drained during heat waves, and hormones can play a role," Dr. Tripti Raheja, Director - Obstetrics & Gynecology at the CK Birla Hospital (R), Delhi, told HealthandMe.

Women are more likely to feel this during certain hormonal phases, such as menstruation, PMS, pregnancy, perimenopause, or menopause.

“Women’s core temperatures rise after ovulation. That, combined with a higher surface area-to-mass ratio, means they absorb heat more quickly,” Mike Tipton, professor and leading expert in applied physiology at the University of Portsmouth, was quoted as saying to Thisdaylive.com.

Women in perimenopause or menopause may experience hot flashes, night sweats, and sleep disturbances, making heat waves exhausting.

Also read:Heatwave Hassles: What Body Odour Could Say About Your Health

Iron deficiency or heavy bleeding can also lower energy levels, and extreme heat may worsen weakness.

Pregnant women naturally have higher metabolic demands, so dehydration and fatigue can set in faster.

Without sufficient hydration, blood flow to the placenta might be reduced, potentially harming the baby. Heat exhaustion in pregnancy can cause early labor or stillbirth. Thyroid disorders and PCOS can also contribute to fatigue and reduced overall energy levels, Dr. Raheja said.

"Long exposure to high temperatures can disrupt the balance between hormones such as estrogen, progesterone, and thyroid hormones, which regulate energy, mood, and metabolism," Dr. Sakshi Goel, Senior Consultant Obstetrics & Gynecology at Rainbow Children's Hospital, Delhi, told HealthandMe.

Dehydration further worsens this by affecting circulation and temperature control, leading to exhaustion, headaches, and dizziness.

Moreover, sleep disturbances from hot nights can impair melatonin production and disrupt overall hormonal rhythms. This leads to poor recovery and low energy the next day.

How Women Can Protect Their Health From Heatwaves

Read: Excessive Energy Drinks Damaging Young Adults’ Livers, Experts Warn

Understanding how heat affects hormonal health lets women take steps to manage fatigue and maintain overall well-being during extreme weather.

To cope better, the experts suggested prioritizing hydration and including ORS when needed.

Dr. Goel noted that even mild fluid loss can hurt circulation and lower the body’s ability to regulate temperature. This can lead to exhaustion, headaches, and dizziness. Other preventive measures include:

• Avoiding long sun exposure during peak hours.
• Eating lighter, balanced meals and avoid stepping out during peak afternoon heat.
• Wearing breathable clothing and ensure adequate sleep in a cool environment.
• Gentle movements, such as walking or stretching, can improve circulation and mood.
• If fatigue is severe, persistent, or associated with dizziness, palpitations, irregular periods, or excessive weakness, it is important to seek medical evaluation rather than dismissing it as just the weather.

We usually think of nature as something pleasant. A place to relax, unwind, and maybe take a break from routine. But over time, it is becoming clearer that it is not just about feeling good in the moment. Regular time in natural surroundings actually supports both mental and physical health in ways we often overlook.

Most of us spend our days indoors, moving from one closed space to another. Screens, artificial lighting, constant noise, and very little exposure to natural light or open air. It becomes normal, but the body does not fully adapt to it. The result often shows up as poor sleep, frequent fatigue, irritability, or a constant sense of mental heaviness.

Earth Day: How Nature Boosts Mind

Spending time in nature does not act like a quick fix. But it does help the system slowly come back into balance. It helps reduce stress at a deeper level.

Stress is not always obvious. It builds quietly in the background. Being in natural spaces helps bring it down in a way that does not require effort. When you are around trees, open skies, or even a small green space, the body begins to relax on its own. Breathing slows, muscles soften, and the mind becomes less tense.

This is why even a short walk outside can leave you feeling lighter. Not because your situation has changed, but because your body is no longer in a constant state of alert.

It supports anxiety and low mood. For people dealing with anxiety or feeling low, being in nature can create some distance from repetitive thoughts. The mind is usually busy replaying or anticipating things. In a natural setting, attention shifts outward. You begin to notice small details without trying.

That shift matters. It gives the mind a break from itself.

Over time, regular exposure to natural environments has been linked to better mood, improved focus, and a greater sense of emotional stability. It does not replace professional help when needed, but it can support recovery in a steady, quiet way.

It improves sleep and daily energy. Sleep is something a lot of people struggle with now, even if they don’t always connect it to their daily routine. When you spend most of your time indoors, your body doesn’t really get clear signals about when to be active and when to slow down.

Getting some natural light during the day, even for a short while, helps reset that rhythm. It tells your body that it’s daytime, which makes it easier to wind down later.

Something as simple as stepping out in the morning or taking a walk in the evening can make a difference over time. Sleep starts to feel more settled, and when that improves, you usually notice it in your mood, your focus, and your energy throughout the day.

Earth Day: How Nature Improves Health

It has an effect on physical health too. The impact is not just mental. Being in natural environments has been associated with lower blood pressure, better heart health, and improved immunity. Fresh air, movement, and reduced stress all contribute to this.

It is not about doing anything intense. Even something as simple as a slow walk, sitting in a park, or just being in a quiet outdoor space can make the body feel a little lighter.

It creates space without asking for effort. One of the reasons nature works so well is that it does not demand anything from you. You do not have to perform, improve, or follow a routine. You can show up tired, distracted, or stressed, and it still helps.

This makes it easier to return to, especially on days when everything else feels like effort. It can be part of everyday life. You do not need a big plan to make this work. A few minutes in sunlight, a short walk in a nearby park, sitting near a tree, or even noticing the sky at the end of the day can be enough to start with.

These small instances do not appear very significant; however, they accumulate over time and provide us with enhanced cognitive functioning, emotional stability, and an overall healthier body.

While Earth Day reminds us of the need for preserving the environment, it is crucial to note that our well-being is directly linked to the environment.

We perform better when we are one with it. Sometimes, all it takes for us to take care of ourselves is just stepping out into the natural world.

India is seeing a steady and worrying rise in breast cancer cases, with numbers nearly doubling over the past ten years in many urban areas. What was once considered a gradual increase has now become much more visible across the country.

Over the last two decades, breast cancer cases have been slowly increasing. But in the last decade, the rise has been sharper. At the same time, there has been a major shift in the type of cancers affecting women. Earlier, cervical cancer was the most common. Today, breast cancer has taken that position across India.

Why Breast Cancer Cases Are Rising?

One of the biggest reasons behind this rise is that lifestyles have changed, especially among urban dwellers. Diets are now richer in fats, with physical activities taking a backseat, leading to obesity becoming normal. These factors, along with hormonal changes, delayed pregnancies, and genetic risks, all contribute to a higher chance of developing breast cancer.

At the same time, there is also a more encouraging side to this story. More women today are getting diagnosed earlier than before. A decade ago, many patients would come in with advanced stages of the disease. Now, a larger number are being detected in Stage 1 and Stage 2. This shift is important because early detection significantly improves survival.

Better awareness and easier access to screening have played a big role in this change. Campaigns during Breast Cancer Awareness Month have helped bring conversations around breast cancer into the mainstream. More women are now opting for regular check-ups and mammograms, which means cancers are being caught earlier.

However, the overall numbers still remain a concern. It is estimated that one in every 25 to 28 women in India will develop breast cancer at some point in their lives. When this is applied to the country’s population, it translates into a very large number of women being affected.

The important thing to understand is that this rise is not due to one single reason. It is a mix of lifestyle changes, increased awareness, better detection, and possibly hormonal and environmental factors that are still being studied.

Importance Of Early Screening

The way forward is clear. Regular screening is one of the most effective tools available today. Women above the age of 40 should ideally undergo a mammogram every year, even if there are no symptoms. Early-stage breast cancer can be treated very effectively, with cure rates going up to nearly 99% when detected at the earliest stage.

While the numbers may seem alarming, there is also a sense of progress. More awareness, better screening, and earlier diagnosis mean that outcomes are improving. The focus now needs to be on making screening a routine habit and encouraging healthier lifestyles.

Breast cancer is on the rise in India, but with the right approach, it is also one of the cancers where early action can make the biggest difference.