For over 15 years, Dr Anthony Shum, a pulmonologist at the University of California, San Francisco has been studying a rare genetic disorder called the COPA Syndrome. It stands for coatomer subunit alpha and is a rare, inherited disorder that affects the lungs, joint, and kidney. The National Organization for Rare Disorder also notes that it is a genetic autoimmune disorder that is caused by mutations in the COPA gene. This disease affects families unpredictably—some individuals with the mutation develop severe lung damage early in life, while others remain completely healthy. Now, Shum’s team has discovered a protective genetic variant that may offer new hope for treatment.

A Breakthrough

Researchers found that some relatives of COPA Syndrome patients stayed healthy despite carrying the same COPA gene mutation that causes the disease. The key difference? These unaffected individuals had a protective version of another gene called HAQ-STING.

When scientists introduced HAQ-STING into diseased lung cells from COPA patients, the cells returned to a balanced state, suggesting that this gene could be used as a therapy.

“We really think HAQ-STING could be a gene therapy tool and a step toward a cure,” said Shum, whose findings were published in the Journal of Experimental Medicine.

Families Who Solved The Mystery

Shum’s journey into COPA Syndrome research began in 2011 when he treated a young woman, Letasha, who had severe lung bleeding. Her mother, Betty Towe, mentioned that Letasha’s sister, Kristina, had suffered from similar symptoms. Over the years, Betty had taken both daughters on a four-hour trip to UCSF for treatment. After tracing their family history, Shum discovered that their distant relatives in Texas and Oakland also had lung problems and arthritis. In 2015, Shum, along with scientists from Baylor College of Medicine and Texas Children’s Hospital identified the COPA gene mutation. They realized that it was the common factor behind the illness. However, only some of the 30 individuals with the mutation actually developed symptoms, leaving a major question unanswered.

The Domino Effect

It was established that it occurs when a mutated COPA gene causes another gene STING to go overdrive. The STING that helps fight infections in COPA patients, remain permanently active, which leads to chronic inflammation that damages the lungs, kidneys, and joints. In 2020, while studying STING’s role in the disease, researchers discovered a key variation: HAQ-STING. This version of STING, present in about one-third of the population, appeared to neutralize the harmful effects of the COPA mutation.

To confirm their theory, the scientists needed both affected and unaffected family members to participate in the testing. Letasha, Kristina and Betty immediately volunteered. The researchers then analyzed DNA samples from 26 COPA patients and their healthy relatives. They also conducted CT scans and blood tests to ensure that unaffected members did not have any hidden symptoms. When the findings were all clear, it was revealed that all the healthy individuals had HAQ-STING, while none of the COPA patients did. This was the first known case of a common gene variant completely protecting against a severe genetic disease.

Encouraged by this discovery, researchers tested HAQ-STING’s effects in a lab setting. They introduced it into diseased lung cells from COPA patients, and the cells returned to normal function.

Way Ahead

Shum believes HAQ-STING could lead to game-changing treatments, including:

• Prenatal gene therapy for babies diagnosed with COPA Syndrome before birth
• Aerosol delivery of HAQ-STING for adults, directly targeting the lungs

Before publishing their findings, Shum called Betty with the news—her own HAQ-STING gene had protected her from the disease. He also informed Letasha and Kristina, who were overwhelmed with relief and joy.

“We always believed Dr. Shum would get to the bottom of it,” said Letasha. “This discovery is going to change lives.”

Cervical cancer is still one of the most common cancers for women in India. It's mostly caused by a persistent infection with the Human Papillomavirus, or HPV for short.

This virus spreads through sexual contact and often doesn't show any symptoms early on. A lot of women don't even realize they have the virus until abnormal cell changes start to show up.

The World Health Organization says that cervical cancer is one of the most preventable cancers if people get vaccinated and screened on time.

Also Read: Woman Lost Weight On Mounjaro But Her Breasts Didn't Stop Growing, This Is Why...

In India, thousands of women still die every year because they're diagnosed late and don't have enough access to regular screening. That's where the new nationwide HPV vaccination drive is starting to make a difference.

Let’s Talk About The HPV Vaccine

The HPV vaccine basically protects against the types of the virus that are most often linked to cervical cancer. You get it as a shot, and it works best if you get it before you're exposed to the virus, usually when you're a young teenager. But it can still help even if you get it later.

India's really pushing to get this vaccine out there, which is a big change in how they're handling public health. The idea is pretty straightforward and impactful: protect young girls before the virus can do any damage. By focusing on school-aged kids and making sure parents know about it, they're trying to fix a problem that's been around for ages.

Why Is This Drive So Important?

Cervical cancer doesn't just pop up overnight. It usually takes years for an HPV infection to turn into cancer. This long window gives us a chance to prevent it. Vaccination stops the infection at the start, and screening catches early cell changes before they get serious.

Public health experts think that if enough people get vaccinated, we could prevent up to 80,000 cancer deaths in India every year over time. That number isn't just a statistic. It's about saving the lives of mothers, daughters, and sisters with a simple preventive measure.

The vaccine has been studied a lot worldwide and has strong safety and effectiveness data. Countries with high vaccination rates are already seeing big drops in HPV infections and precancerous lesions.

Also Read: 15 States Sue Trump Administration Over Revised Vaccine Schedule

Busting Myths And Building Trust

Even though there's solid science behind vaccines, there's still a lot of wrong info out there. Some parents are concerned about safety or what might happen down the road. Others think getting vaccinated makes kids sexually active sooner, but studies don't back that up.

Getting the facts straight is super important for dealing with these worries. The HPV vaccine doesn't mess with fertility or hormones. It just teaches your body to fight off certain types of the virus.

Getting communities involved, having healthcare pros on board, and running educational campaigns are all crucial for building trust. When families learn that this vaccine can prevent cancer, more people are on board.

Beyond Shots: Screening Matters

Vaccination isn't the only answer. Women who are already sexually active still need regular cervical screening. Pap smears and HPV testing are still super important for catching things early. India's bigger plan includes making screening programs at primary healthcare centers stronger. When vaccination and screening work together, the impact gets way bigger.

Getting Closer To Wiping Out Cancer

The World Health Organization wants to get rid of cervical cancer as a public health issue this century, and India's vaccination plan fits right in with that big goal.

This isn't just about medicine; it's about really caring for women's health and stopping problems before they start. In a country where getting cancer treatment can be tough, prevention is our best bet.

Cervical cancer is mostly preventable. If we keep vaccinating, have good screening, and make sure everyone knows the facts, we could save thousands of lives every year. This campaign is a huge step towards a future where cervical cancer is rare, not something we just expect.

Kenyan-Mexican actress Lupita Nyong’o has revealed that her fibroids have returned after undergoing surgery in 2014 -- now doubling up to 50, raising awareness about the often-overlooked health condition in women.

Speaking at the Today show, the Oscar-winning star Nyong’o said that she was first diagnosed with fibroids, a noncancerous tumor -- about 30 in number -- in 2014.

The growths made of muscle and tissue were removed with myomectomy, the fibroid-removal surgery.

However, the fibroids came back after over a decade, with the largest being the size of an orange, Nyong’o said.

She noted that the doubled-up fibroids are causing her more pain, while her treatment options remain largely the same.

“The first time I got the fibroids taken out, they took out 23,” she said on the show. “And this time, I’ve been informed two years ago that I have over 50.”

“And I’m being faced with the same options,” she added. “Surgery or live with the pain.”

Even as she is contemplating her treatment options, the A Quiet Place: Day One star opened up about feeling left alone and scared for her reproductive health during the initial phase.

She is now speaking out and connecting with other women suffering like her. Nyong’o is also advocating and raising money for scientists to research less invasive and non-invasive treatment methods for fibroids.

I was told that fibroids were something women live with. In refuse to accept that. Millions of women are suffering in silence, and we deserve better answers, better care and better options," Nyong’o wrote in a post on Instagram.

What Are Fibroids

Uterine fibroids are noncancerous growths that form inside or on the uterus. They are very common, affecting an estimated 40 to 80 percent of people with a uterus between the ages of 30 and 50.

In some cases, fibroids do not cause any noticeable symptoms, which means many people may not realize they have them. However, when symptoms are present, they often include:

• Heavy menstrual bleeding or painful periods
• Longer or more frequent periods
• Pelvic pressure or pain
• Frequent urination or trouble urinating
• Growing stomach area
• Constipation
• Pain in the stomach area or lower back, or pain during sex

Obesity and a higher body mass index (BMI) are the most common risk factors that can increase the chances of developing fibroids. Others include family history, not having children, early onset of menstruation (getting your period at a young age), and late age of menopause.

How To Treat Fibroids? Can They Recur?

There are several tests that can be done to confirm fibroids and determine their size and location.

These tests can include ultrasonography, magnetic resonance imaging (MRI), computed tomography (CT) scan, hysteroscopy, and laparoscopy.

Myomectomy is a commonly used surgical procedure to remove fibroids. There are several types of myomectomy, and they are used depending on the location of the fibroids, their size, and number.

The types of myomectomy procedures include hysteroscopy, laparoscopy, laparotomy, hysterectomy, uterine fibroid embolization, and radiofrequency ablation (RFA).

Even after a successful myomectomy, new fibroids can still develop. The recurrence risk is more common among young adults (under age 40) with many fibroids. The risk is less among people near menopause or with few fibroids.

Visit your doctor if you have:

• Pelvic pain that doesn't go away
• Heavy or painful periods that limit what you can do
• Spotting or bleeding between periods
• Trouble emptying your bladder
• Ongoing tiredness and weakness, which can be symptoms of anemia, meaning a low level of red blood cells.

Sepsis that happened by a lick from a pet dog led to a woman losing all four of her limbs. Health and Me had previously reported that a Birmingham based woman, 56-year-old pharmacy worker Manjit Sangha caught sepsis from the lick of her pet dog. She spent her night in coma in the hospital and had to lose all her limbs. This happened because bacteria from dog's lick entered her body through a cut or a scratch. This led to sepsis, where the immune system's reaction to infection damaged the body's own tissues and organs.

This has brought a lot of attention on what sepsis is and what are the symptoms one must be aware of. As per the Sepsis Alliance, one must know about TIME to be aware of sepsis.

Unique Symptoms of Sepsis

TIME stands for temperature, infection, mental decline and extremely ill. If you notice these symptoms, rush to the hospital.

• T for Temperature: If you notice your body temperature rising or falling
• I for Infection: If you see signs or symptoms of any infection
• M for Mental Decline: If you feel confused, sleepy and difficult in rising
• E for Extremely Ill: If you feel severe pain, discomfort, shortness of breath

Unique Symptoms Of Sepsis: What To Know About Temperature

Your body temperature normally stays steady at about 98.6°F (37°C), with small changes based on activity, surroundings, and time of day. A reading of 100°F (37.7°C) or higher is considered a fever. During infection, the body often heats up to help fight germs. However, some people experience an unusual drop in temperature instead. Because of this, both a spike and a fall in temperature can be warning signs of sepsis.

Unique Symptoms of Sepsis: How To Know If You Have An Infection?

When an infection stays in one area, its symptoms usually match the site involved. A urinary tract infection may cause burning while urinating or frequent urges, pneumonia can bring cough and chest pain, and an infected cut may show redness or pus.

Read: Where You Get Your Rabies Shot Matters: Doctor Explains Why Rabies Vaccines Should Not Be Given In Buttocks

If the infection spreads through the body, broader symptoms like fever, tiredness, and body aches can appear. In some cases, an infection may not cause obvious symptoms at all. This is especially important to remember after surgery, medical procedures, skin injuries, or close contact with someone who is sick.

Unique Symptoms of Sepsis: What To Look Out For Mental Decline?

Sepsis can also alter how the brain functions. Some people, particularly older adults, may not develop the usual infection symptoms. Instead, they might suddenly become confused or show a sharp worsening of existing dementia. Marked drowsiness or unusual sleepiness is another common sign.

Unique Symptoms of Sepsis: Signs That You Are Extremely Ill

Many sepsis survivors recall feeling sicker than ever before. They describe overwhelming symptoms such as the most severe sore throat or abdominal pain they had experienced, along with a frightening sense that they might not survive.

Unique Symptoms Of Sepsis In Children

Unique Symptoms Of Sepsis In Adults

• High blood cell count
• Immature white blood cells in circulation
• Elevated plasma C-reactive protein
• Elevated procalctonin (PCT)
• Low blood pressue
• Low central venous or mixed venous oxygen saturation
• High cardiac index
• Low oxygen level
• Low urine output
• High creatinine in the blood
• Coagulation or clotting abnormalities
• Absent bowel sounds
• Low platelets in blood
• High bilirubin levels
• High lactate in blood
• Decreased capillary filling or mottling