For over 15 years, Dr Anthony Shum, a pulmonologist at the University of California, San Francisco has been studying a rare genetic disorder called the COPA Syndrome. It stands for coatomer subunit alpha and is a rare, inherited disorder that affects the lungs, joint, and kidney. The National Organization for Rare Disorder also notes that it is a genetic autoimmune disorder that is caused by mutations in the COPA gene. This disease affects families unpredictably—some individuals with the mutation develop severe lung damage early in life, while others remain completely healthy. Now, Shum’s team has discovered a protective genetic variant that may offer new hope for treatment.

A Breakthrough

Researchers found that some relatives of COPA Syndrome patients stayed healthy despite carrying the same COPA gene mutation that causes the disease. The key difference? These unaffected individuals had a protective version of another gene called HAQ-STING.

When scientists introduced HAQ-STING into diseased lung cells from COPA patients, the cells returned to a balanced state, suggesting that this gene could be used as a therapy.

“We really think HAQ-STING could be a gene therapy tool and a step toward a cure,” said Shum, whose findings were published in the Journal of Experimental Medicine.

Families Who Solved The Mystery

Shum’s journey into COPA Syndrome research began in 2011 when he treated a young woman, Letasha, who had severe lung bleeding. Her mother, Betty Towe, mentioned that Letasha’s sister, Kristina, had suffered from similar symptoms. Over the years, Betty had taken both daughters on a four-hour trip to UCSF for treatment. After tracing their family history, Shum discovered that their distant relatives in Texas and Oakland also had lung problems and arthritis. In 2015, Shum, along with scientists from Baylor College of Medicine and Texas Children’s Hospital identified the COPA gene mutation. They realized that it was the common factor behind the illness. However, only some of the 30 individuals with the mutation actually developed symptoms, leaving a major question unanswered.

The Domino Effect

It was established that it occurs when a mutated COPA gene causes another gene STING to go overdrive. The STING that helps fight infections in COPA patients, remain permanently active, which leads to chronic inflammation that damages the lungs, kidneys, and joints. In 2020, while studying STING’s role in the disease, researchers discovered a key variation: HAQ-STING. This version of STING, present in about one-third of the population, appeared to neutralize the harmful effects of the COPA mutation.

To confirm their theory, the scientists needed both affected and unaffected family members to participate in the testing. Letasha, Kristina and Betty immediately volunteered. The researchers then analyzed DNA samples from 26 COPA patients and their healthy relatives. They also conducted CT scans and blood tests to ensure that unaffected members did not have any hidden symptoms. When the findings were all clear, it was revealed that all the healthy individuals had HAQ-STING, while none of the COPA patients did. This was the first known case of a common gene variant completely protecting against a severe genetic disease.

Encouraged by this discovery, researchers tested HAQ-STING’s effects in a lab setting. They introduced it into diseased lung cells from COPA patients, and the cells returned to normal function.

Way Ahead

Shum believes HAQ-STING could lead to game-changing treatments, including:

• Prenatal gene therapy for babies diagnosed with COPA Syndrome before birth
• Aerosol delivery of HAQ-STING for adults, directly targeting the lungs

Before publishing their findings, Shum called Betty with the news—her own HAQ-STING gene had protected her from the disease. He also informed Letasha and Kristina, who were overwhelmed with relief and joy.

“We always believed Dr. Shum would get to the bottom of it,” said Letasha. “This discovery is going to change lives.”

Iron deficiency is one of the most common nutritional problems among women, but in the juggle between professional and household responsibilities, a majority of women tend to ignore their health. However, the detecting the mild symptoms in the beginning can help boost treatment and improve quality of life for women, said experts, while stressing the need for timely screening, ahead of International Women's Day.

International Women's Day is observed globally on March 8 every year.

According to health experts, in a month, around 5 out of 10 women between the ages of 30 and 45 visit doctors with complaints such as persistent weakness, headaches, and tiredness. These symptoms are often linked to iron deficiency and put women at risk of developing anemia.

“Iron deficiency is a matter of concern among women, because the symptoms, such as fatigue and weakness, are neglected until the condition becomes serious,” said Dr. Upasana Garg, Regional Technical Chief, Apollo Diagnostic Mumbai.

Dr. Garg said iron deficiency can be detected through simple blood tests that will be advised by the expert and will play a pivotal role in early diagnosis and timely treatment.

These include tests for

• Hemoglobin levels -- are carried out to measure the amount of oxygen-carrying protein in the blood and indicate if a woman has anemia

• Serum ferritin and iron levels -- to gauge the amount of stored iron in the body and help detect iron deficiency even before anemia develops

• A complete blood count (CBC) -- to measure red blood cells, including their size and number, which checks if the body is producing healthy blood cells.

Anemia In Women

Anemia is a major public health concern, mainly affecting young children, pregnant and postpartum women, and menstruating adolescent girls and women.

The World Health Organization (WHO) estimates that 40 percent of all children aged 6–59 months, 37 percent of pregnant women, and 30 percent of women 15–49 years of age worldwide are affected by anemia.

Anemia occurs when there isn’t enough hemoglobin in the body to carry oxygen to the organs and tissues.

In severe cases, anemia can cause poor cognitive and motor development in children. It can also cause problems for pregnant women and their babies. It is often caused by a lack of iron in the blood.

“Iron is a necessary mineral which helps the body to produce hemoglobin, a protein in red blood cells that carries oxygen to different parts of the body. When the body does not have enough iron, it is unable to produce healthy red blood cells. This condition is known as iron deficiency or iron deficiency anemia,” said Dr. Ritu Agrawal, Gynecologist, Zynova Shalby Hospital, Mumbai.

Dr. Agrawal said that women are more likely to experience iron deficiency when compared to men.

The major reason is blood loss during menstruation, and women who have heavy periods are at a higher risk.

During pregnancy, when the body needs extra iron to support the growing baby, the risk of anemia increases in the mother.

Other factors include poor diet, skipping meals, and not eating enough iron-rich foods.

Early Screening And Treatment

The common symptoms of anemia in women include:

constant tiredness,

weakness,

pale skin,

shortness of breath,

dizziness,

headaches,

hair fall

difficulty concentrating

frequent infections due to reduced immunity

Dr. Agrawal said that 50 percent of women tend to ignore early symptoms of anemia.

“In a month, around 5 out of 10 women between the ages of 30–45 visit with complaints such as persistent weakness, headaches, and tiredness, which are often linked to iron deficiency and put them at risk of developing anemia. If iron deficiency is not treated in time, it can lead to several health complications,” she added.

Severe anemia can also lead to heart-related problems, such as irregular heartbeat or shortness of breath.

The experts noted that detecting iron deficiency on time and initiating immediate treatment is necessary for women's better health.

Management of iron deficiency includes

• improving diet and taking iron supplements as advised by any expert
• Have iron-rich foods like spinach, beans, lentils, nuts, and dates
• Vitamin C–rich foods, such as oranges and lemons.

American TV personality Oprah Winfrey turned heads at the Paris Fashion Week with her slim figure and sparked talks on the popular weight-loss drug Ozempic.

The now viral videos show Oprah, 72, in jeans and a jacket. Usually seen in parted hair, Oprah also resorted to a ponytail and was wearing tinted sunglasses.

While several netizens expressed concerns about her health, others also spoke about the effects of Ozempic, widely used for weight loss.

“What in the Ozempic Oprah is going on here?”, wrote a user.

“I'm afraid Oprah may OD on Ozempic. Welfare check, please!” another added.

People also commented on the seemingly bigger head and frail body.

“Her head looks way too big for her body. Is it Ozempic or Oprah?” wrote a user.

“She looked good, but she seemed frail,” the netizens said, while another stated, “But having a head that big still is crazy”.

The video also showed Gayle King, another TV host and a longtime friend of Oprah, with a lean figure. Gayle, 71, also rocked a warm-brown look, paired with a fitted top and a black leather jacket.

Does Oprah Winfrey Take Ozempic?

Oprah has openly shared the use of a GLP-1 agonist for weight loss. However, she never mentioned any brand names.

“One of the things that I realized the very first time I took a GLP-1 was that all these years I thought that thin people just had more willpower, they ate better foods, they were able to stick to it longer, they never had a potato chip, and then I realized the very first time I took the GLP-1 that, 'Oh, they're not even thinking about it. They're only eating when they're hungry, and they're stopping when they're full,” Oprah said in a podcast early in 2025.

In 2023, speaking to People, she said she uses the weight-loss medication as a tool to quiet the food noise.

“I now use it as I feel I need it, as a tool to manage not yo-yoing. It quiets the food noise,” she had told the publication.

Oprah's Strength Training Session

In an Instagram post in February 2026, Oprah also showcased her strength training evolution, highlighting the benefits of daily workouts for bone health and her impressive plank progress.

She told her fans that while in 2024, she struggled to hold a plank for more than 10 seconds, now she manages to do a 1-minute plank routine.

Can Ozempic Really Help You Lose Weight?

While Ozempic was originally developed and FDA-approved as an injectable medication to help manage type 2 diabetes, it has gained immense popularity for its ability to produce significant weight loss.

The drug is popular for its active ingredient, semaglutide, which works by mimicking a hormone that regulates blood sugar and appetite.

However, there are several concerns over its side effects. The loss of lean mass, which includes muscle, has emerged as the biggest concern.

Studies have proven that it provides significant weight loss and also reduces major cardiovascular risks and boosts kidney health, among others.

However, common side effects include:

• gastrointestinal (nausea, vomiting, diarrhea, constipation),
• pancreatitis,
• gallbladder issues,
• face sagging
• dental issues like tooth decay, erosion.

She wakes before dawn, packs lunches, manages households, holds careers together, and still finds time to ask everyone else, "Are you okay?" The Indian woman is, in every sense, the backbone of her family. And yet, in giving so much of herself to others, she often becomes the last person she takes care of.

This International Women's Day, that needs to change.

Cancer remains one of the gravest health threats facing Indian women today.

Breast cancer has become the most frequently diagnosed cancer among Indian women — and unlike in Western countries, it is striking women in their 30s and 40s, at the very peak of their lives.

Cervical cancer, though almost entirely preventable, continues to claim thousands of lives every year — not because medicine has failed, but because awareness has.

Ovarian cancer, often called the "silent killer," is frequently caught only at advanced stages, making early vigilance all the more critical.

Thyroid cancer is emerging as a cancer that disproportionately affects women — occurring nearly three times more often in women than men. The good news is that it is also one of the most treatable cancers when detected early.

Women who notice a lump or swelling in the neck, unexplained hoarseness, or difficulty swallowing should not dismiss these signs.

A simple ultrasound and blood test can go a long way in ruling out — or catching — a problem early. The truth, however, is not bleak — it is urgent.

Early Detection Saves Lives

Most cancers, when found at an early stage, are highly treatable. Women above 40 should schedule regular clinical breast examinations and mammography.

Cervical cancer screening through a Pap smear or HPV test, starting as early as age 25–30, can detect precancerous changes before they ever become cancer. These tests are quick, safe, and available — what they need most is for women to simply show up.

Prevention, too, begins with everyday choices. Avoiding tobacco in all its forms — cigarettes, gutka, paan — is the single most powerful step. Regular physical activity, a diet rich in fruits and vegetables, maintaining a healthy weight, limiting alcohol, and getting the "HPV vaccine" (ideally between ages 9 and 14) can dramatically reduce cancer risk.

And perhaps just as importantly: listen to your body. An unusual lump, unexplained bleeding, or a symptom that won't go away is not something to push aside for later. Later can cost everything.

A healthy woman builds a healthy family — and a healthy nation. This Women's Day, let's give every woman around us the most meaningful gift possible: the reminder that her health is not selfish, it is essential.