For over 15 years, Dr Anthony Shum, a pulmonologist at the University of California, San Francisco has been studying a rare genetic disorder called the COPA Syndrome. It stands for coatomer subunit alpha and is a rare, inherited disorder that affects the lungs, joint, and kidney. The National Organization for Rare Disorder also notes that it is a genetic autoimmune disorder that is caused by mutations in the COPA gene. This disease affects families unpredictably—some individuals with the mutation develop severe lung damage early in life, while others remain completely healthy. Now, Shum’s team has discovered a protective genetic variant that may offer new hope for treatment.

A Breakthrough

Researchers found that some relatives of COPA Syndrome patients stayed healthy despite carrying the same COPA gene mutation that causes the disease. The key difference? These unaffected individuals had a protective version of another gene called HAQ-STING.

When scientists introduced HAQ-STING into diseased lung cells from COPA patients, the cells returned to a balanced state, suggesting that this gene could be used as a therapy.

“We really think HAQ-STING could be a gene therapy tool and a step toward a cure,” said Shum, whose findings were published in the Journal of Experimental Medicine.

Families Who Solved The Mystery

Shum’s journey into COPA Syndrome research began in 2011 when he treated a young woman, Letasha, who had severe lung bleeding. Her mother, Betty Towe, mentioned that Letasha’s sister, Kristina, had suffered from similar symptoms. Over the years, Betty had taken both daughters on a four-hour trip to UCSF for treatment. After tracing their family history, Shum discovered that their distant relatives in Texas and Oakland also had lung problems and arthritis. In 2015, Shum, along with scientists from Baylor College of Medicine and Texas Children’s Hospital identified the COPA gene mutation. They realized that it was the common factor behind the illness. However, only some of the 30 individuals with the mutation actually developed symptoms, leaving a major question unanswered.

The Domino Effect

It was established that it occurs when a mutated COPA gene causes another gene STING to go overdrive. The STING that helps fight infections in COPA patients, remain permanently active, which leads to chronic inflammation that damages the lungs, kidneys, and joints. In 2020, while studying STING’s role in the disease, researchers discovered a key variation: HAQ-STING. This version of STING, present in about one-third of the population, appeared to neutralize the harmful effects of the COPA mutation.

To confirm their theory, the scientists needed both affected and unaffected family members to participate in the testing. Letasha, Kristina and Betty immediately volunteered. The researchers then analyzed DNA samples from 26 COPA patients and their healthy relatives. They also conducted CT scans and blood tests to ensure that unaffected members did not have any hidden symptoms. When the findings were all clear, it was revealed that all the healthy individuals had HAQ-STING, while none of the COPA patients did. This was the first known case of a common gene variant completely protecting against a severe genetic disease.

Encouraged by this discovery, researchers tested HAQ-STING’s effects in a lab setting. They introduced it into diseased lung cells from COPA patients, and the cells returned to normal function.

Way Ahead

Shum believes HAQ-STING could lead to game-changing treatments, including:

• Prenatal gene therapy for babies diagnosed with COPA Syndrome before birth
• Aerosol delivery of HAQ-STING for adults, directly targeting the lungs

Before publishing their findings, Shum called Betty with the news—her own HAQ-STING gene had protected her from the disease. He also informed Letasha and Kristina, who were overwhelmed with relief and joy.

“We always believed Dr. Shum would get to the bottom of it,” said Letasha. “This discovery is going to change lives.”

Kidneys are extraordinary organs that perform critical tasks on a continual basis, e.g., filtering out waste, keeping electrolytes balanced, controlling blood pressure, and providing metabolic stability.

However, many people don’t pay enough attention to keeping their kidneys healthy until they discover that substantial damage has already happened.

Some of the most prevalent and underestimated threats to kidney functioning include uncontrolled blood pressure, chronic anxiety, and unhealthy living.

The Effect Of Hypertension On Kidney Function

Hypertension (high blood pressure) is considered one of the most prevalent causes of CKD (chronic kidney disease) worldwide.

The kidneys need the support of a complicated design of tiny blood vessels to carry out their task of removing waste from the bloodstream. An ongoing and increased blood pressure level will slowly harm these small blood vessels by reducing their ability to function normally. As time passes, this injury will result in scar formation of the kidney tissue, causing a continual decline in the kidney’s ability to filter.

Hypertension is known as a silent killer because it frequently has no symptoms for many years. By the time someone experiences symptoms of high blood pressure, their kidneys may have already been damaged for a considerable period.

Chronic stress is often overlooked as an indirect cause of kidney damage. When we are under chronic stress, our sympathetic nervous system is activated, and the amount of stress hormones (cortisol and adrenaline) in our bodies increases.

These physiological changes lead to prolonged increases in blood pressure and blood glucose; both of these risk factors are bad for our kidneys. Chronic stress may cause people to engage in unhealthy coping strategies like poor diet, smoking, consuming alcohol, or not being physically active, which also increases their risk of kidney damage.

Our long-term kidney function is largely determined by lifestyle choices, including our dietary habits. Diets high in sodium, processed foods, and unhealthy fats increase the probability that you will develop hypertension, metabolic disorders, or some combination of both of these, which puts even more strain on your kidneys.

The sedentary lifestyle associated with obesity, insulin resistance, and cardiovascular disease are all significant contributors to chronic kidney disease. Dehydration, taking large amounts of over-the-counter medications (especially NSAIDs), and using tobacco products are all additional risk factors for progressive loss of kidney function.

Preventative Interventions For Kidney Health

Many of these risk factors can be addressed through prevention.

Regular monitoring of blood pressure, using mindfulness and other methods to manage stress levels, and maintaining a healthy diet full of fruits, vegetables, and whole grains will all help to reduce the strain on your kidneys.

Regular health screenings for people who have some of the above-mentioned risk factors (e.g., diabetes, high blood pressure, etc.) will give people an opportunity to identify problems early, giving them time to adjust their lifestyle or possibly seek some other type of treatment (e.g., taking medication).

The Importance of Early Awareness and Intervention

Gaining and maintaining awareness of what contributes to the health of the kidneys can help protect the kidneys.

Gaining awareness of and taking action against hidden risks, such as high blood pressure or chronic stress, and making positive changes to your lifestyle will help maintain kidney function and minimize the likelihood of developing long-term complications in the future.

Early intervention is the most effective method for protecting the health of your kidneys.

In my early years of clinical practice, it was not uncommon to see children admitted with severe measles, struggling with complications that could turn fatal.

Polio was not a chapter in textbooks—it was visible in outpatient clinics, in children who came in with permanent disabilities, and in families learning to cope with lifelong consequences.

Vaccines Save Lives: From Polio To COVID

Diarrheal diseases filled pediatric wards, often pushing already fragile children to the brink. These were not isolated cases; they were a pattern we saw far too often. What changed this reality was not a coincidence. It was vaccines.

Over the years, I have witnessed firsthand how immunization has transformed pediatric care in India. The introduction of the measles vaccine in 1985, followed by the second dose in 2010, has brought us to a point where a disease once feared by every parent is now on the verge of elimination.

Similarly, the impact of the Pulse Polio Immunization campaign has been extraordinary. From routinely seeing children affected by polio, we moved to a historic milestone—India being declared polio-free on March 17, 2014. For clinicians who have seen both sides, this shift is nothing short of remarkable.

The change has been equally significant in other areas. There was a time when severe diarrhea dominated pediatric admissions. Today, with better sanitation and the introduction of the rotavirus vaccine in 2016, we see far fewer cases of severe rotavirus-related illness. This is not just a statistic—it is reflected in fewer hospital admissions, less distress for families, and better outcomes for children.

More recently, during the COVID-19 pandemic, the importance of vaccines became evident on an unprecedented scale. As healthcare providers, we experienced the strain of the pandemic firsthand. The introduction of vaccines in January 2021 marked a turning point. It not only reduced the severity of illness but also brought a sense of control in an otherwise uncertain situation. The ability to protect lives at such a scale reaffirmed what medicine has known for decades—vaccines are among the most powerful tools we have.

Across diseases, across decades, and across generations, one truth remains consistent: vaccines save lives. However, despite these clear gains, we are now witnessing a concerning shift.

Vaccine Hesitancy And Emerging Diseases

In recent years, vaccine hesitancy has started to emerge—even among well-informed populations. As a clinician, this is deeply concerning. When diseases become less visible, people begin to underestimate their impact. Questions arise, doubts increase, and misinformation often fills the gap.

The consequences of this are already visible globally. The re-emergence of measles in countries with strong healthcare systems is a clear warning.

As per CDC data from March 18, 2026, the United States has reported 1,362 confirmed measles cases across 20 states, with multiple outbreaks—after more than two decades of control. This is not due to a lack of availability of vaccines, but due to reduced uptake.

From a medical standpoint, this is both predictable and preventable. Vaccination is not just about protecting one individual—it is about safeguarding entire communities. In my practice, I often remind families that immunization protects not only their child but also those who are more vulnerable—newborns, pregnant women, and individuals with weakened immunity. When vaccination rates decline, this collective protection weakens, and diseases find their way back.

History has shown us that progress in public health is not permanent unless it is sustained. The absence of disease does not mean the absence of risk—it often reflects the success of prevention.

Timely Immunization Is Key

The way forward is clear. We must continue to ensure timely immunization, strengthen awareness, and address concerns with clarity and empathy. As healthcare providers, it is our responsibility to build trust and provide evidence-based guidance. As a community, it is equally important to rely on science and not misinformation.

Vaccines have already proven their value—both in data and in daily clinical practice. The science is robust, the outcomes are visible, and the impact is undeniable. The question is no longer whether vaccines work. The question is whether we will continue to trust and use them.

Because the cost of inaction is not theoretical—it is seen in preventable illness, avoidable hospitalizations, and lives that could have been saved. For every generation, vaccines have worked. It is now our responsibility to ensure they continue to.

India is surely winning the battle against malaria. However, the disease is still around. Medicines and nets help a lot, but doctors point to something else. They say the real cure starts before you even get sick. It all comes down to keeping your local area totally clean.

This fever only spreads through female Anopheles mosquitoes. They do not need big ponds to multiply. A little dirty water trapped inside an old tyre, a thrown-away plastic cup, or a coconut shell is all they need. That is where the cycle of malaria starts. Within days, larvae turn into mosquitoes, and the infection begins to move through nearby homes. This is why many doctors put it plainly. Treating a patient comes later. Stopping the mosquito from breeding is the foundation of the battle against malaria, and that depends on everyday cleanliness by everybody residing in each lane and building.

The official health data brings major relief. Malaria is finally losing its grip. Fresh WHO reports prove this fact. In 2017, India struggled with nearly 64 lakh cases. But the figures show a steep fall in the number of cases by 2023. The total patient count stood at just 20 lakh. We are looking at a clear 69 percent drop in a very short time. Seeing this huge improvement, the WHO took India off its critical 'High Burden to High Impact' list in 2024.

Data released by the government of India tells a similar story. Figures from the National Center for Vector-Borne Diseases Control under the Union Health Ministry show a decline in the number of deaths by more than 78 percent between 2015 and 2023. The target now is clear. The government has set a very clear target. They want malaria cases to hit zero by 2027. After that, the final goal is to wipe out this disease from the entire country by 2030.

We are winning this fight, but the danger is still far from over. Cover your water tanks properly. Clean the open drains. Do not let rainwater collect near your house. These small daily habits easily stop the disease from spreading.

However, the health department alone cannot achieve this massive target. Fogging and spraying of chemicals done by municipal bodies only kill adult mosquitoes that are already flying. The fight is local. If water tanks are shut tight, drains are not clogged, and garbage isn’t left to collect rainwater, the danger drops quickly.

When a society maintains clean surroundings, it naturally destroys the breeding grounds for mosquitoes. If the mosquitoes cannot breed, the chain of infection breaks automatically. As India moves closer to its 2030 malaria-free goal, keeping our streets, parks, and homes clean is no longer just a civic duty. It is our absolute first line of medical defense against a deadly disease.