For over 15 years, Dr Anthony Shum, a pulmonologist at the University of California, San Francisco has been studying a rare genetic disorder called the COPA Syndrome. It stands for coatomer subunit alpha and is a rare, inherited disorder that affects the lungs, joint, and kidney. The National Organization for Rare Disorder also notes that it is a genetic autoimmune disorder that is caused by mutations in the COPA gene. This disease affects families unpredictably—some individuals with the mutation develop severe lung damage early in life, while others remain completely healthy. Now, Shum’s team has discovered a protective genetic variant that may offer new hope for treatment.

A Breakthrough

Researchers found that some relatives of COPA Syndrome patients stayed healthy despite carrying the same COPA gene mutation that causes the disease. The key difference? These unaffected individuals had a protective version of another gene called HAQ-STING.

When scientists introduced HAQ-STING into diseased lung cells from COPA patients, the cells returned to a balanced state, suggesting that this gene could be used as a therapy.

“We really think HAQ-STING could be a gene therapy tool and a step toward a cure,” said Shum, whose findings were published in the Journal of Experimental Medicine.

Families Who Solved The Mystery

Shum’s journey into COPA Syndrome research began in 2011 when he treated a young woman, Letasha, who had severe lung bleeding. Her mother, Betty Towe, mentioned that Letasha’s sister, Kristina, had suffered from similar symptoms. Over the years, Betty had taken both daughters on a four-hour trip to UCSF for treatment. After tracing their family history, Shum discovered that their distant relatives in Texas and Oakland also had lung problems and arthritis. In 2015, Shum, along with scientists from Baylor College of Medicine and Texas Children’s Hospital identified the COPA gene mutation. They realized that it was the common factor behind the illness. However, only some of the 30 individuals with the mutation actually developed symptoms, leaving a major question unanswered.

The Domino Effect

It was established that it occurs when a mutated COPA gene causes another gene STING to go overdrive. The STING that helps fight infections in COPA patients, remain permanently active, which leads to chronic inflammation that damages the lungs, kidneys, and joints. In 2020, while studying STING’s role in the disease, researchers discovered a key variation: HAQ-STING. This version of STING, present in about one-third of the population, appeared to neutralize the harmful effects of the COPA mutation.

To confirm their theory, the scientists needed both affected and unaffected family members to participate in the testing. Letasha, Kristina and Betty immediately volunteered. The researchers then analyzed DNA samples from 26 COPA patients and their healthy relatives. They also conducted CT scans and blood tests to ensure that unaffected members did not have any hidden symptoms. When the findings were all clear, it was revealed that all the healthy individuals had HAQ-STING, while none of the COPA patients did. This was the first known case of a common gene variant completely protecting against a severe genetic disease.

Encouraged by this discovery, researchers tested HAQ-STING’s effects in a lab setting. They introduced it into diseased lung cells from COPA patients, and the cells returned to normal function.

Way Ahead

Shum believes HAQ-STING could lead to game-changing treatments, including:

• Prenatal gene therapy for babies diagnosed with COPA Syndrome before birth
• Aerosol delivery of HAQ-STING for adults, directly targeting the lungs

Before publishing their findings, Shum called Betty with the news—her own HAQ-STING gene had protected her from the disease. He also informed Letasha and Kristina, who were overwhelmed with relief and joy.

“We always believed Dr. Shum would get to the bottom of it,” said Letasha. “This discovery is going to change lives.”

The growing trend of medical tourism or cosmetic tourism has become increasingly popular in the age of social media. The dramatic before-and-after results, the thrill of returning home with a new look, and a quenched wanderlust have only contributed to this trend.

While the appeal is evident, we cannot help but ignore the risks and complications one can face while traveling overseas for a cosmetic procedure. On World Plastic Surgery Day, take a look at what you are in for if you are planning to fly off for a procedure.

Why People Travel Abroad For Cosmetic Procedures?

One of the biggest reasons why people travel abroad for cosmetic procedures is the cost. Procedures like liposuction, tummy tucks, breast enhancement, rhinoplasty, and dental veneers can cost almost 30% to 70% less in some countries than in the United States, United Kingdom, or Australia.

Many cosmetic packages also come with other attractive deals like luxury recovery packages, airport transfers, and hotel stays, combined vacation and surgery experiences, among others.

For some patients, these deals make cosmetic procedures more affordable and convenient. However, lower prices do not always necessarily mean lower quality. But the concern is that patients do not adequately evaluate the standards of clinics before they travel.

Also read: Plastic Surgery Myths Debunked: Experts Explain Cosmetic vs Reconstructive Surgery

Hidden Risks And Complications

Here are some risks and complications that one ought to be aware of before booking those flight tickets.

Infections And Delayed Wound Healing

Patients who fly home too soon may experience wound breakdown, excessive swelling, or bleeding that requires urgent medical attention.

Dr Banodkar says, “Unqualified practitioners, who perform these procedures, may not be adequately trained; they might cause a permanent scar on the skin, or they might even cause a simple infection of the skin that can result in sepsis.”

Unsatisfactory Results

Every surgery carries the possibility of asymmetry, scarring, implant problems, or the need for revision surgery due to unqualified or unskilled practitioners. This could incur hidden costs of corrective surgeries.

Dr. Pravin Banodkar, Consultant Dermatologist, Saifee Hospital, Mumbai, told HealthandMe, “There are hidden costs of any corrective treatment which can obviously be much more than what is actually spent for the procedure.”

Limited Follow-Up Care

Many cosmetic procedures require multiple follow-up visits, wound checks, suture removal, and monitoring complications.

Patients returning home shortly after surgery may have limited access to the operating surgeon. Local doctors may also be unfamiliar with the exact techniques or implants used, making management more challenging.

Also read: How Reconstructive Plastic Surgery Transforms Lives After Trauma And Cancer

Limited Legal Protection

Dr Banodkar explains, “Many times, the people who are not trained don't know how to manage complications, and as a result, they are unable to diagnose the problem. Due to this, the adverse effects of the procedure will only increase.”

If complications occur, seeking compensation or legal action across international borders can be difficult and expensive, as medical regulations, malpractice laws, and patient protections vary widely between countries.

For years, the word "cancer" filled people with fear. Many still believe that a cancer diagnosis means the end. As an oncologist practicing in a Tier-2 city, I see every day that this is no longer true.

With early detection and modern treatment, cancer is now often curable. And the best part: you no longer need to travel to metros to get world-class care.

Why Early Detection Saves Lives

Cancer found early is cancer that can be treated easily.

- Breast cancer detected early has a survival rate of over 90%

- Cervical cancer can be prevented with a simple HPV vaccine and regular screening

- Oral, colon, lung, and prostate cancers also respond far better when caught before they spread

The problem: Most patients still come to us when symptoms become severe.

My request to you: Don’t wait. If there is a lump, persistent cough, bleeding, or unexplained weight loss for more than 2-3 weeks, please see a doctor. A 15-minute screening can add years to your life.

Also read: New Painless Brush Test Detects Oral Cancer In Just 60 Minutes With Over 90% Accuracy

Tier-2 Cities Are No Longer Behind

Earlier, patients from smaller cities had only two options: travel repeatedly to big metro hospitals or settle for limited local treatment. Both were exhausting.

That has changed.

Today, most Tier-2 cities now have comprehensive cancer centers with:

CT/MRI/PET scans, advanced pathology labs, chemotherapy daycare, radiation therapy, and experienced cancer surgeons.

This means diagnosis, surgery, chemotherapy, immunotherapy, and follow-up can all happen close to your home, with family support and at a lower cost.

Treatment Today Is Smarter, Not Just Stronger

Chemotherapy is still important, but it’s no longer the only option.

1. Targeted Therapy: Medicines that attack only cancer cells based on genetic testing. Fewer side effects.

2. Immunotherapy: Boosts your own immune system to fight cancer. Giving great results in lung cancer, kidney cancer, and blood cancers.

3. Advanced Radiation: Delivers precise radiation to the tumor while protecting healthy organs.

4. Minimally Invasive Surgery: Keyhole and robotic surgeries mean smaller cuts, less pain, faster recovery. Even elderly patients can now safely undergo surgery.

Also read: Cancer Kills Over 26,000 Daily; Cases to Hit 35 Million by 2050, Says WHO Report

Let’s Break 3 Dangerous Myths

Myth 1: "Cancer always causes pain in the beginning"

Fact: Most early cancers are painless. Don’t wait for pain.

Myth 2: "Surgery makes cancer spread"

Fact: This is false. Surgery is often the most curative treatment when done on time.

Myth 3: "Alternative therapies can cure cancer"

Fact: Diet, yoga, and wellness help with strength and side effects. But they cannot replace doctor-prescribed treatment. Delaying proven treatment reduces your chances of cure.

A Message Of Hope

A cancer diagnosis will change your life, but it does not have to end it. Across Tier-2 India, I am seeing patients go back to work, celebrate birthdays, and live full lives after cancer.

The key is 3 things: Awareness, Early Check-ups, and Trusting Modern Medicine. If you or a loved one has symptoms, please consult an oncologist early. Treatment closer to home is now possible, effective, and affordable. Cancer can be fought. And it can be won.

By Dr. Vikas Talreja, Oncologist, Regency Health, Kanpur

It's just July, and Mumbai’s monsoon has been swinging from tumultuous to alarmingly parched. When the climate shifts with such volatility, it’s bound to have an impact on your overall health.

From dehydration risk to chances of gastrointestinal infections, here’s how rapidly changing weather can take a toll on your mental health.

Impact Of Extreme Weather On Health

Respiratory Effects

HealthandMe spoke to Dr. Abizer Manked, Consultant Physician and Diabetologist at Saifee Hospital, Mumbai. One of the health impacts extreme weather has is on the respiratory system. Due to the increase of irritants and allergens, several respiratory issues can be triggered.

Dr Manked says, “The temperature and humidity can irritate our airways. This can trigger asthma, bronchitis, and allergies. It can also trigger coughing, giving us throat infections, and making it harder to breathe. This is especially true for people who already face breathing problems.”

Allergy Triggers

The expert says that allergy episodes increase significantly during the monsoon, especially when the rain is inconsistent. An increase in humidity paves the way for mould and fungi growth, which can make allergies worse.

Cold And Flu-Like Symptoms

When temperatures and humidity change rapidly, our immune response can take a hit. It can lead to frequent episodes of common cold, cough, and other flu-like symptoms.

“When the weather changes quickly, it can also make us more likely to get infections like the common cold and flu. The weather itself does not make us sick. The sudden change can affect our body’s ability to fight off infections. When we are indoors with a lot of people during the rain, viruses spread easily,” Dr Manked explains.

Also read: Delhi's Poor AQI, Monsoon Conditions Put Children's Lungs at Risk: Ways to Keep Kids Safe

Heat Exhaustion And Dehydration

When a heavy rain episode is followed by hot and humid weather, it can lead to increased risk of heat-related illnesses.

Dr Manked says, “The humidity makes it hard for our bodies to cool down. This can make us tired, give us headaches, and leave us dehydrated more frequently. It can even lead to heat exhaustion. This especially holds true for people who work outside or spend a lot of time in the sun.”

Viral And Parasite Infections

In the monsoon, Mumbai sees the highest number of cases of viral and parasite infections like dengue and malaria.

Flooding and waterlogging create breeding hotspots for mosquitoes, which can lead to more chances of infections. Poor hygiene and maintenance of surroundings further increase the risk.

Fungal Infections

Staying in damp clothes and shoes for long periods increases the risk of contracting fungal infections. The expert says it’s crucial to keep one’s clothes dry to avoid the riks of skin infections.

Also read: Allergic Rhinitis Affects 1 In 10 Indian Adults. Here's Why Monsoon Makes It Worse, And What Helps

How To Protect Yourself From Weather Changes?

Simple precautions can go a long way in reducing health risks during an irregular monsoon:

• Drink clean, safe water, and avoid consuming food exposed to floodwater.
• Wash hands regularly with soap, especially before eating.
• Avoid walking through floodwater whenever possible.
• Wear waterproof footwear if you must step into waterlogged areas.
• Keep homes dry and well-ventilated to reduce mold growth.
• Empty containers that collect rainwater to prevent mosquito breeding.
• Stay hydrated even if the weather feels cooler.
• Change out of wet clothes promptly and dry your feet thoroughly.
• Seek medical attention if you develop persistent fever, severe diarrhea, breathing difficulties, or symptoms after exposure to floodwater.

Children, older adults, and people with asthma, diabetes, high blood pressure, obesity, and other chronic illnesses are more likely to face these health effects during the monsoon. It is, therefore, crucial to take extra precautions and care for those with a weakened immune system.