For over 15 years, Dr Anthony Shum, a pulmonologist at the University of California, San Francisco has been studying a rare genetic disorder called the COPA Syndrome. It stands for coatomer subunit alpha and is a rare, inherited disorder that affects the lungs, joint, and kidney. The National Organization for Rare Disorder also notes that it is a genetic autoimmune disorder that is caused by mutations in the COPA gene. This disease affects families unpredictably—some individuals with the mutation develop severe lung damage early in life, while others remain completely healthy. Now, Shum’s team has discovered a protective genetic variant that may offer new hope for treatment.

A Breakthrough

Researchers found that some relatives of COPA Syndrome patients stayed healthy despite carrying the same COPA gene mutation that causes the disease. The key difference? These unaffected individuals had a protective version of another gene called HAQ-STING.

When scientists introduced HAQ-STING into diseased lung cells from COPA patients, the cells returned to a balanced state, suggesting that this gene could be used as a therapy.

“We really think HAQ-STING could be a gene therapy tool and a step toward a cure,” said Shum, whose findings were published in the Journal of Experimental Medicine.

Families Who Solved The Mystery

Shum’s journey into COPA Syndrome research began in 2011 when he treated a young woman, Letasha, who had severe lung bleeding. Her mother, Betty Towe, mentioned that Letasha’s sister, Kristina, had suffered from similar symptoms. Over the years, Betty had taken both daughters on a four-hour trip to UCSF for treatment. After tracing their family history, Shum discovered that their distant relatives in Texas and Oakland also had lung problems and arthritis. In 2015, Shum, along with scientists from Baylor College of Medicine and Texas Children’s Hospital identified the COPA gene mutation. They realized that it was the common factor behind the illness. However, only some of the 30 individuals with the mutation actually developed symptoms, leaving a major question unanswered.

The Domino Effect

It was established that it occurs when a mutated COPA gene causes another gene STING to go overdrive. The STING that helps fight infections in COPA patients, remain permanently active, which leads to chronic inflammation that damages the lungs, kidneys, and joints. In 2020, while studying STING’s role in the disease, researchers discovered a key variation: HAQ-STING. This version of STING, present in about one-third of the population, appeared to neutralize the harmful effects of the COPA mutation.

To confirm their theory, the scientists needed both affected and unaffected family members to participate in the testing. Letasha, Kristina and Betty immediately volunteered. The researchers then analyzed DNA samples from 26 COPA patients and their healthy relatives. They also conducted CT scans and blood tests to ensure that unaffected members did not have any hidden symptoms. When the findings were all clear, it was revealed that all the healthy individuals had HAQ-STING, while none of the COPA patients did. This was the first known case of a common gene variant completely protecting against a severe genetic disease.

Encouraged by this discovery, researchers tested HAQ-STING’s effects in a lab setting. They introduced it into diseased lung cells from COPA patients, and the cells returned to normal function.

Way Ahead

Shum believes HAQ-STING could lead to game-changing treatments, including:

• Prenatal gene therapy for babies diagnosed with COPA Syndrome before birth
• Aerosol delivery of HAQ-STING for adults, directly targeting the lungs

Before publishing their findings, Shum called Betty with the news—her own HAQ-STING gene had protected her from the disease. He also informed Letasha and Kristina, who were overwhelmed with relief and joy.

“We always believed Dr. Shum would get to the bottom of it,” said Letasha. “This discovery is going to change lives.”

Young and older people are reporting persistent coughs and throat irritation following Diwali celebrations, with rising pollution levels, smog and exposure to firecracker emissions likely contributing to these symptoms.

However, when these symptoms persist or worsen, they could sometimes signal a more serious respiratory infection, including pneumonia, experts warned on World Pneumonia Day, observed every year on November 12.

Speaking to HealthandMe, Dr. Neelam H. Jain, Internal Medicine Specialist and Medical Educator at Apollo Hospitals, Bengaluru, said doctors' clinics tend to get swamped every November with patients who blame their lingering coughs entirely on post-Diwali smog.

"While particulate matter and fireworks residue certainly irritate airways, a cough that persists or worsens demands a closer look. Sometimes, what feels like seasonal irritation masks something more serious: pneumonia," she said.

The deterioration in air quality after Diwali can particularly affect children, older adults and people with pre-existing lung conditions.

"Exposure to elevated levels of particulate matter (PM2.5 and PM10), along with toxic gases from firecrackers and vehicular emissions, can irritate the respiratory tract, trigger inflammation and worsen existing respiratory illnesses," Dr. Vikas Mittal, Director and Pulmonologist at CK Birla Hospital, Delhi, told HealthandMe.

Also read: Delhi Pollution: Is Your Child's Cough Or Wheezing A Warning Sign? When Should Parents Worry?

What Are The Warning Signs Of Pneumonia?

Not every persistent cough indicates pneumonia. Exposure to firecracker emissions and poor air quality can cause airway irritation and inflammation. However, certain symptoms warrant medical attention.

Dr. Jain said a cough that changes from dry to producing thick, green or rust-coloured phlegm, particularly when accompanied by persistent fever, chills and sharp chest pain while breathing deeply, requires further evaluation.

"Pneumonia inflames the air sacs in one or both lungs, filling them with fluid or pus," she said.

Other symptoms that may indicate pneumonia include shortness of breath, fatigue and weakness. Older adults, children and people with underlying conditions such as asthma or chronic obstructive pulmonary disease (COPD) are particularly vulnerable to respiratory complications.

"If your post-Diwali cough lasts longer than two weeks, is accompanied by shortness of breath, or leaves you unusually fatigued, do not write it off as just bad air. Listen to your body and consult a doctor for an evaluation. Early diagnosis makes all the difference," Dr. Jain added.

People experiencing breathlessness, chest pain or high fever should seek medical attention without waiting for two weeks.

Can Air Pollution Increase The Risk Of Pneumonia?

Persistent cough, throat irritation, wheezing, breathlessness and chest tightness are common symptoms of pollution-induced respiratory irritation.

Dr. Mittal explained that air pollution does not directly cause pneumonia. However, it can impair the lungs' natural defence mechanisms, making people more susceptible to respiratory infections.

It can also aggravate conditions such as asthma, bronchitis and COPD, potentially increasing the risk of complications.

Read More: Dry Cough, Breathlessness May Not Always Be Asthma — Could It Be ILD?

How To Protect Your Lungs During High Pollution Levels

Delhi's overall Air Quality Index (AQI) rose to 319 on November 12, placing it in the 'very poor' category. As of 6:30 am, 36 of the city's 58 air quality monitoring stations recorded AQI readings above 300.

Dr. Mittal advised people to minimise outdoor exposure during periods of poor air quality and use well-fitted N95 masks when stepping outside.

Other precautions include:

• Keep indoor spaces adequately ventilated.
• Avoid strenuous outdoor activities when pollution levels are high.
• Stay adequately hydrated.
• Seek timely medical advice if respiratory symptoms persist or worsen.

What Is Pneumonia And How Can You Prevent It?

Pneumonia is an infection that causes inflammation in one or both lungs. It can be caused by bacteria, viruses or fungi. The infection causes the air sacs in the lungs, called alveoli, to fill with fluid or pus, making breathing difficult.

It can range from mild to life-threatening, particularly among young children, older adults and people with weakened immune systems. Some forms can also spread through respiratory droplets.

Measures to reduce the risk of pneumonia include:

• Vaccination: Get vaccinated against influenza, pneumococcal infections and COVID-19, as recommended by a healthcare professional.
• Good hygiene: Wash your hands regularly with soap and water to reduce the spread of germs.
• Healthy lifestyle: Maintain a balanced diet, exercise regularly and get adequate rest.
• Avoid smoking: Smoking can damage the lungs' natural defences against infections.

Catherine, Princess of Wales, recently opened up about her cancer recovery. In an interview, the Princess, widely known as Kate Middleton, spoke about how nature helped her navigate the physical and emotional challenges of her illness. She said that spending time outdoors became an integral part of her cancer recovery.

Her experience adds to the growing research into how exposure to natural environments may help the well-being of people battling cancer.

Kate Middleton's Cancer Recovery

Kate announced her cancer diagnosis in March 2024 and said she was undergoing preventive chemotherapy. She completed treatment in September 2024 and announced in January 2025 that she was in remission. She did not publicly disclose the type of cancer she was diagnosed with.

Speaking to nature writer Robert Macfarlane for Country Life magazine, Kate recalled the advice she received during her treatment and recovery. “I was told in hospital that my recovery would not be linear. There will be good and bad days, that it will take time,” she said.

She compared the recovery process to the natural cycles of rest and renewal, adding, “This is the same in nature. It shows us that periods of rest, reflection and renewal are equally as important as moments of growth.”

The Princess said spending time outdoors had helped her reconnect with herself during a difficult period.

“What I feel really passionate about, having had first-hand experience, is approaching illness and recovery through a whole-person approach. Yes, serious illness creates a lot of physical challenges, but there is also a deeper part to all of us,” she said.

“Nature has allowed me to find a deeper connection to my mind, body and spirit,” she added.

Also read: 'Miracle' Breast Cancer Pill That 'Slows Progression Of Disease' To Be Rolled Out On NHS

Can Spending Time In Nature Help Cancer Patients?

Research suggests that spending time in nature may support psychological well-being among people undergoing cancer treatment.

A 2023 scoping review published in International Journal of Environmental Research and Public Health examined 12 studies involving 2,786 cancer survivors. The studies were based on different forms of nature exposure, including walking outdoors, forest therapy, gardening and even experiencing natural environments through virtual reality.

Researchers reported improvements in several areas, including anxiety, depression, sleep, stress, fatigue and pain. Participants also described nature as an important source of comfort while battling cancer.

Another review published in Seminars in Radiation Oncology in July 2026 examined interventions related to nature for adults diagnosed with cancer. It identified benefits like reduced psychological distress, improved mood, sleep, quality of life and social connection.

The review studied interventions like gardening, forest therapy, physical activity in nature, therapeutic landscapes and nature prescriptions.

Also read: Christina Applegate Suspects Breast Implants May Have Caused MS-Like Symptoms: What Is the Condition?

A cancer diagnosis affects physical as well as mental health. Patients may experience anxiety, depression, fear of recurrence, uncertainty about the future and emotional exhaustion during treatment and recovery. Spending time in nature can help in several ways:

1. Alleviation Of Stress And Anxiety

Natural environments can give a break from medical appointments, treatment schedules and daily responsibilities. Research suggests that exposure to green spaces may help reduce psychological distress and improve mood.

2. Gentle Physical Activity

Walking in a garden, park or other outdoor space can provide an opportunity for movement. Physical activity, when appropriate to a patient's treatment stage, can help improve physical functioning and reduce fatigue related to treatment.

3. Social Connection

Gardening groups, nature walks and outdoor activities can help patients reconnect with family members, friends and other people. Social support can be valuable during periods of emotional difficulty.

4. Sleep And Relaxation

Outdoor time can encourage relaxation and help establish regular daily routines. Exposure to natural daylight also helps regulate the body's circadian rhythm, which helps sleep-wake pattern.

While research suggests that nature-based activities may support mental health and aspects of quality of life, there is no formidable evidence that spending time outdoors can eliminate cancer risk entirely, shrink tumours or prevent recurrence.

These activities should be viewed as supplementary forms of support, not alternatives to surgery, chemotherapy, radiotherapy, immunotherapy or other prescribed cancer treatments.

It is also important to know that patients may not be able to spend time outdoors during treatment. Fatigue, reduced immunity, mobility limitations, treatment side effects and environmental conditions can affect what is safe and comfortable.

Patients should discuss appropriate physical activity and outdoor exposure with their doctors, especially if they are immunocompromised or recovering from surgery.

Actress Jenny McCarthy has opened up about the lasting effects of her battle with mold poisoning, revealing that the experience has left her with post-traumatic stress disorder (PTSD), anxiety and a fear of being exposed to mold again.

During a recent episode of her podcast, The Jenny McCarthy-Wahlberg Show, the actress spoke about the physical and emotional toll of the illness, the extensive measures she has taken to avoid further exposure and her ongoing recovery.

McCarthy said she had to discard most of her belongings after the suspected exposure, including her clothes and furniture.

"I wound up throwing everything away," she said, adding that she and her husband, Donnie Wahlberg, also left their furniture behind when they moved out of their Los Angeles home.

Although she believes the exposure may have originated in her makeup room, she said she did not want to take any chances.

Jenny McCarthy Says Mold Poisoning Left Her With PTSD

Also read: One In Three Hospital Patients With Serious Mould Infections Died, CDC Study Finds

McCarthy said the experience made her fearful of encountering mold wherever she went. She described having histamine reactions in different places and struggling with everyday activities, including travelling in Ubers, visiting restaurants and boarding airplanes.

The actress also revealed that the prolonged health struggles contributed to a nervous breakdown, leaving her husband worried about her well-being.

Having undergone 11 surgeries in 15 months, McCarthy said she became increasingly afraid that her body would start "falling apart again."

She also described the emotional strain of her treatment, which involved taking around 100 pills a day.

"I find myself crying sometimes," she said, describing how difficult it was to manage the medication and the uncertainty surrounding her recovery.

Jenny McCarthy's Symptoms And Mycotoxin Poisoning Diagnosis

Read More: Cladophialophora bantiana: US CDC Flags Surge In Deadly Brain Fungus Cases

McCarthy first spoke publicly about her health ordeal in March, describing six months of what she called "living hell."

She previously reported experiencing an infected root canal, pus-filled growths on her eyelids, mouth infections, tooth pain, skin rashes and food allergies.

The actress said a doctor diagnosed her with mycotoxin poisoning in December 2025. She has since described being in remission for seven months and focusing on recovery.

Her efforts to avoid further exposure have also been extensive. In an October 29 podcast episode, she revealed that she had been sleeping in a tent in her backyard because she was afraid of being exposed to mold indoors.

"Because I am paranoid now about basically sleeping anywhere, I live in a tent," she said.

McCarthy has also spoken about concerns over her breast implants and whether they could be associated with mold exposure. During a November 3 podcast episode, she discussed the issue with plastic surgeon Dr Terry Dubrow, who has treated her previously.

What Is Mycotoxin Poisoning And How Can It Affect Health?

Mycotoxins are toxic substances produced by certain molds and other fungi. Exposure can occur through contaminated food or environments, depending on the type of toxin and the route of exposure.

According to the Cleveland Clinic, mycotoxin exposure can affect different parts of the body, including the digestive system, eyes and mouth. Mold exposure can also trigger allergic reactions and worsen respiratory conditions such as asthma.

The health effects depend on factors such as the type of mycotoxin, the amount and duration of exposure, and an individual's susceptibility.