For over 15 years, Dr Anthony Shum, a pulmonologist at the University of California, San Francisco has been studying a rare genetic disorder called the COPA Syndrome. It stands for coatomer subunit alpha and is a rare, inherited disorder that affects the lungs, joint, and kidney. The National Organization for Rare Disorder also notes that it is a genetic autoimmune disorder that is caused by mutations in the COPA gene. This disease affects families unpredictably—some individuals with the mutation develop severe lung damage early in life, while others remain completely healthy. Now, Shum’s team has discovered a protective genetic variant that may offer new hope for treatment.

A Breakthrough

Researchers found that some relatives of COPA Syndrome patients stayed healthy despite carrying the same COPA gene mutation that causes the disease. The key difference? These unaffected individuals had a protective version of another gene called HAQ-STING.

When scientists introduced HAQ-STING into diseased lung cells from COPA patients, the cells returned to a balanced state, suggesting that this gene could be used as a therapy.

“We really think HAQ-STING could be a gene therapy tool and a step toward a cure,” said Shum, whose findings were published in the Journal of Experimental Medicine.

Families Who Solved The Mystery

Shum’s journey into COPA Syndrome research began in 2011 when he treated a young woman, Letasha, who had severe lung bleeding. Her mother, Betty Towe, mentioned that Letasha’s sister, Kristina, had suffered from similar symptoms. Over the years, Betty had taken both daughters on a four-hour trip to UCSF for treatment. After tracing their family history, Shum discovered that their distant relatives in Texas and Oakland also had lung problems and arthritis. In 2015, Shum, along with scientists from Baylor College of Medicine and Texas Children’s Hospital identified the COPA gene mutation. They realized that it was the common factor behind the illness. However, only some of the 30 individuals with the mutation actually developed symptoms, leaving a major question unanswered.

The Domino Effect

It was established that it occurs when a mutated COPA gene causes another gene STING to go overdrive. The STING that helps fight infections in COPA patients, remain permanently active, which leads to chronic inflammation that damages the lungs, kidneys, and joints. In 2020, while studying STING’s role in the disease, researchers discovered a key variation: HAQ-STING. This version of STING, present in about one-third of the population, appeared to neutralize the harmful effects of the COPA mutation.

To confirm their theory, the scientists needed both affected and unaffected family members to participate in the testing. Letasha, Kristina and Betty immediately volunteered. The researchers then analyzed DNA samples from 26 COPA patients and their healthy relatives. They also conducted CT scans and blood tests to ensure that unaffected members did not have any hidden symptoms. When the findings were all clear, it was revealed that all the healthy individuals had HAQ-STING, while none of the COPA patients did. This was the first known case of a common gene variant completely protecting against a severe genetic disease.

Encouraged by this discovery, researchers tested HAQ-STING’s effects in a lab setting. They introduced it into diseased lung cells from COPA patients, and the cells returned to normal function.

Way Ahead

Shum believes HAQ-STING could lead to game-changing treatments, including:

• Prenatal gene therapy for babies diagnosed with COPA Syndrome before birth
• Aerosol delivery of HAQ-STING for adults, directly targeting the lungs

Before publishing their findings, Shum called Betty with the news—her own HAQ-STING gene had protected her from the disease. He also informed Letasha and Kristina, who were overwhelmed with relief and joy.

“We always believed Dr. Shum would get to the bottom of it,” said Letasha. “This discovery is going to change lives.”

Multivitamins are essentially dietary supplements containing a combination of various vitamins and minerals, often used to bridge nutritional gaps in the diet, treat deficiencies caused by poor nutrition or illness and support overall health.

Designed to provide a broad range of nutrients in one daily dose, they are available in tablets, capsules, gummies or liquids and are widely recommended to adults of all ages and genders.

But which vitamins do women need and when should you be taking them?

Dr Yashica Gudesar, Director & Unit Head of Obstetrics & Gynecology, Max Super Speciality Hospital, Dwarka exclusively tells Healthandme: "A woman’s nutritional needs change at different stages of life, from adolescence to reproductive years, pregnancy, and menopause. While food should always be the primary source of nutrients, certain vitamins may be required as women age or depending on lifestyle, diet, and health conditions."

"There’s honestly no universal vitamin checklist that works for every woman. The needs change with age, lifestyle, stress, whether one is planning a pregnancy, and of course, what the blood reports actually show," Bhakti Samant, Chief Dietician, Kokilaben Dhirubhai Ambani Hospital further told this publication.

Here are the supplements you need to stock your medicine cabinet with:

1. Vitamin D

Vitamin D is a fat-soluble nutrient essential for strong bones, immune function, and calcium absorption, often synthesized when skin is exposed to sunlight or obtained via food and supplements.

Symptoms of Vitamin D deficiency include bone pain, muscle weakness, and depression. Deficiencies are common due to low sun exposure or poor diet, leading to rickets in children and osteomalacia or osteoporosis in adults.

However, this can be avoided by consuming a combination of calcium and Vitamin D supplements. Dr Ginni Kalra, Head Dietician, Aakash Healthcare explained to Healthandme: "One of the frequently deficient nutrients in women is vitamin D. It is very important in calcium absorption, bone density, immune homeostasis and mood balance. In most adult women, the amount needed is 600-800 IU (15-20 mcg) per day although deficient women can take 1000-2000 IU per day under the supervision.

"Calcium is necessary in bone density especially in women post-menopause who experience rapid bone loss owing to the diminishing estrogen. Adult women should take 1,000 mg per day that rises to 1200 mg past 50 years. Calcium supplements are most ideal in separated doses of 500-600 mg each time and preferably following meals. When combined with vitamin D, absorption will enhance much better."

"Calcium becomes especially important after the age of 30, and even more after menopause. It can be taken after meals, often divided into two doses for better absorption," Dr Gudesar added.

Moreover, Samant advised: "Vitamin D is best taken with a meal that has some fat. Calcium (around 1000–1200 mg daily) is better split into two doses and should not be taken with iron."

2. Iron

A vital mineral, iron plays a very crucial role in human functioning by helping create hemoglobin to transport oxygen throughout the body, essential for energy and muscle function. Low iron levels can result in decreased oxygen transport and leading to symptoms like extreme fatigue, weakness, pale skin, cold hands/feet and shortness of breath.

While an iron deficiency is usually caused by poor diet, blood loss due to menstrual periods, ulcers, cancer, or regular use of pain relievers like aspirin or malabsorption issues, it can be remedied through supplements.

Dr Kalra explains: "Iron is also essential especially in menstruating women because they lose blood monthly. It may result in an iron deficiency which causes fatigue, loss of hair, brittle nails, and poor concentration. The acceptable amount of iron that is recommended to be taken by women aged 19 to 50 is approximately 18 mg, but this reduces to 8 mg after menopause.

"Iron supplements are better absorbed on an empty stomach or when taken with vitamin C and not when they are taken with calcium, tea or coffee as they have been found to interfere with absorption. The intake in the morning is usually desirable, but in case of gastrointestinal discomfort, it should be avoided."

3. Vitamin C

Vitamin C is essential for the body because it serves as a powerful antioxidant, supports the immune system, and is crucial for the synthesis of collagen, which is vital for wound healing and the maintenance of healthy skin, bones, and blood vessels.

It also enhances the absorption of iron from plant-based foods and protects cells from damage caused by free radicals, potentially reducing the risk of chronic diseases like cancer and heart conditions.

While, foods such as oranges, lemons, red and green peppers, kiwifruit, broccoli, strawberries, and Brussels sprouts can provide help maintain Vitamin C levels, supplements can help boost absorption and maximize benefits.

Dr Kalra notes: "Vitamin C helps to maintain the immunity, collagen synthesis, and iron uptake. It should be taken in 75 mg daily by adult women. It is soluble in water and can be consumed together with breakfast."

Additionally, she also recommends intaking: "Vitamin E and vitamin A also help the skin, vision, and antioxidant defense, but overconsumption is not advisable because it may be toxic."

4. Omega 3

Omega-3 fatty acids are polyunsaturated fats known for their crucial role in brain function and overall mental health. Fish oil is particularly rich in EPA and DHA, which are vital components of cell membranes and have strong anti-inflammatory effects in the body.

These omega-3s play a critical role in human development, and they are primarily found in fatty fish and fish oil. Some popular sources of Omega-3 include:

• Salmon
• Cod Liver Oil
• Algae Oil
• Oysters
• Nuts and seeds, such as flaxseeds, chia seeds, and walnuts
• Plant oils, such as flaxseed oil, soybean oil, and canola oil
• Fortified foods, such as eggs, yogurt, juices, milk, etc.

But as many people do not consume enough fish, supplementation is often recommended to ensure adequate intake of these essential fatty acids.

Dr Kalra suggests: "Though not vitamins, omega-3 fatty acids are worth mentioning because of the cardiovascular, hormonal, and anti-inflammatory effects. About 250–500 mg of combined EPA and DHA a day may be helpful and is most often administered after meals."

5. Vitamin B12

Symptoms of a Vitamin B12 deficiency often appear slowly. You may not notice them at first, or may blame them on stress, lack of sleep or a busy schedule. However, if the deficiency continues for long, it could lead to serious health problems.

Dr Gudesar recommends: "Vitamin B12 supports nerve health and energy levels. Vegetarian women are more prone to deficiency. It is typically taken in the morning."

"Vitamin B12 is needed to promote nerve well-being, red blood cell building, and energy conversion. The chances of deficiency are increased in vegetarian women because B12 is mostly found in foods of animal origin. The suggested daily dose is 2.4 mcg, but the dosage can be raised in deficiency. It is preferable in the morning as it could increase alertness," Dr Kalra explained.

However, Dr Kalra also advises: "There should be individualization of supplement timing and dosage. Decisions should be based on routine blood tests, dietary assessment, age, lifestyle, and existing medical conditions.

"Excessive supplementation is detrimental, in particular, fat-soluble vitamins. The only safe and effective approach is nutritional adequacy by means of whole foods, and supplements are the supportive therapy only in cases where deficiencies are observed."

The digital revolution has transformed childhood. From online classes to gaming and entertainment, headphones and earphones have become constant companions for children. While technology has brought convenience and learning opportunities, it has also introduced a silent threat, damage to children’s hearing.

In my clinical practice as an ENT surgeon, I am witnessing an alarming increase in young patients presenting with symptoms such as ear discomfort, ringing in the ears (tinnitus), and reduced hearing ability. These issues, once uncommon in children, are now becoming increasingly frequent due to excessive and unsafe use of personal audio devices.

Understanding the Risk

What makes the situation more concerning is that children often do not recognize the early warning signs. By the time symptoms become noticeable, significant damage may have already occurred.

The 60/60 Rule: A Simple Preventive Measure

• Listen at no more than 60% of the maximum volume

• Limit usage to 60 minutes at a time, followed by a break

This simple guideline can significantly reduce the risk of hearing damage and should be strictly followed by children and adolescents.

Warning Signs Parents Must Watch For

• Frequently increasing the volume of devices

• Complaints of ringing, buzzing, or ear pain

• Difficulty in hearing conversations

• Speaking unusually loudly

If any of these symptoms are noticed, it is important to consult an ENT specialist promptly.

Promoting Safe Listening Habits

1. Limit Earphone Use: Encourage children to use speakers whenever possible instead of earphones.

2. Choose Safer Devices: Over-the-ear headphones are generally safer than in-ear earbuds as they reduce direct sound impact.

3. Ensure Quiet Environments: Avoid using headphones in noisy surroundings, as children tend to increase volume to compensate.

4. Take Regular Breaks: Continuous listening should be avoided. Short breaks help the ears recover.

5. Avoid Night-time Use: Using headphones before sleep can harm both hearing and sleep quality.

A Shared Responsibility

Routine hearing check-ups should also be encouraged, especially for children who frequently use headphones for study or entertainment.

The digital age is here to stay, and technology will continue to play a central role in children’s lives. However, safeguarding their health must remain a priority. Hearing is a precious sense that, once lost, cannot be restored.

By adopting simple precautions, spreading awareness, and encouraging responsible use of technology, we can ensure that our children enjoy the benefits of the digital world, without compromising their hearing health.

Today, social media has become the integral part of lives for billions of people around the world in this hyper, connected digital era. Apart from merely using it to maintain relationships, people also utilize these platforms for getting news and trends thus they become so essential to them.

Nevertheless, an increasing number of studies and the community at large are convinced that social media are detrimental to our mental health and general well being.

According to a recent YouGov poll taken in the UK in January 2026, 37 percent of adults gave a general negative review of social media's impact on their mental health, more than twice the amount of people who say otherwise.

Merely 14 percent of them admitted to receiving a positive effect from social media on their mental health.

This trend isn’t limited to one country. Back in 2022, the American Psychiatric Association (APA) Healthy Minds Monthly poll figured out that up to one third of Americans (34 percent) feel social media is more harming than helpful for their mental health, and nearly half of the respondents considered that it has damaged the society at large.

Nevertheless, for many users, especially the young generation, these sensations of harm do not come from nowhere. The Pew Research Center survey, conducted in 2024, discloses that 45 percent of U.S. teenagers think social media is damaging their sleep and 40 percent believe it is having a negative impact on their productivity, which are both key factors of mental health.

Why Do People Feel This Way?

1. Increased Stress, Anxiety, and Depression

Continuous social media usage is linearly correlated each day with increased levels of stress, anxiety, depression, and loneliness, as well as lower quality of sleep. Besides, it also leads to a decrease in feelings of self, worth and overall happiness.

2. Body Image and Self-Comparison

This is what a typical social media scene looks like: vibrant, posh, picturesque, so perfect characters showing off their wonderful lives. For young women these can be simple triggers, uneducated the mind leading to appearance dissatisfaction and the feeling of being a loser in their own lives. Studies show that those who rely excessively on these platforms, especially young women, would be at greatest risk of feeling discontent with their looks or life aspects.

3. Short-Form Video and Mental Fatigue

Short form videos have a negative effect on mental health, as both adolescent and adult users may feel more stressed and anxious, thus account for higher levels of these adverse feelings.

Not Just Mental Health - Physical Impacts Too

Balancing Benefits and Risks

While there have been concerns about this, social media still is not generally perceived as harmful. A lot of users share their positive experiences like obtaining a sense of belonging with friends and community or getting an opportunity to learn and exploring content.

The Pew research on teens is an example where 74 percent of adolescents say social media helps them feel connected to friends, and 34 percent say they at least sometimes get mental health information through it.

This ambiguity shows that social media's impact is not straightforward. It can be a venue for support and connection for some people, while it may increase anxiety or lower self, esteem for others, especially when it is used heavily or without control.

What Experts Suggest

A Broader Conversation

The bottom line is that even though social media has a lot of advantages, the increasing number of studies and the general public's opinion indicate that the issue of mental health is only one of a number of aspects that are significantly and differently influenced by the use of social media. To maintain one's psychological sanity in the era of continuous digital communication, a reasonable, well, informed approach to using social media is likely to be very helpful.