For over 15 years, Dr Anthony Shum, a pulmonologist at the University of California, San Francisco has been studying a rare genetic disorder called the COPA Syndrome. It stands for coatomer subunit alpha and is a rare, inherited disorder that affects the lungs, joint, and kidney. The National Organization for Rare Disorder also notes that it is a genetic autoimmune disorder that is caused by mutations in the COPA gene. This disease affects families unpredictably—some individuals with the mutation develop severe lung damage early in life, while others remain completely healthy. Now, Shum’s team has discovered a protective genetic variant that may offer new hope for treatment.

A Breakthrough

Researchers found that some relatives of COPA Syndrome patients stayed healthy despite carrying the same COPA gene mutation that causes the disease. The key difference? These unaffected individuals had a protective version of another gene called HAQ-STING.

When scientists introduced HAQ-STING into diseased lung cells from COPA patients, the cells returned to a balanced state, suggesting that this gene could be used as a therapy.

“We really think HAQ-STING could be a gene therapy tool and a step toward a cure,” said Shum, whose findings were published in the Journal of Experimental Medicine.

Families Who Solved The Mystery

Shum’s journey into COPA Syndrome research began in 2011 when he treated a young woman, Letasha, who had severe lung bleeding. Her mother, Betty Towe, mentioned that Letasha’s sister, Kristina, had suffered from similar symptoms. Over the years, Betty had taken both daughters on a four-hour trip to UCSF for treatment. After tracing their family history, Shum discovered that their distant relatives in Texas and Oakland also had lung problems and arthritis. In 2015, Shum, along with scientists from Baylor College of Medicine and Texas Children’s Hospital identified the COPA gene mutation. They realized that it was the common factor behind the illness. However, only some of the 30 individuals with the mutation actually developed symptoms, leaving a major question unanswered.

The Domino Effect

It was established that it occurs when a mutated COPA gene causes another gene STING to go overdrive. The STING that helps fight infections in COPA patients, remain permanently active, which leads to chronic inflammation that damages the lungs, kidneys, and joints. In 2020, while studying STING’s role in the disease, researchers discovered a key variation: HAQ-STING. This version of STING, present in about one-third of the population, appeared to neutralize the harmful effects of the COPA mutation.

To confirm their theory, the scientists needed both affected and unaffected family members to participate in the testing. Letasha, Kristina and Betty immediately volunteered. The researchers then analyzed DNA samples from 26 COPA patients and their healthy relatives. They also conducted CT scans and blood tests to ensure that unaffected members did not have any hidden symptoms. When the findings were all clear, it was revealed that all the healthy individuals had HAQ-STING, while none of the COPA patients did. This was the first known case of a common gene variant completely protecting against a severe genetic disease.

Encouraged by this discovery, researchers tested HAQ-STING’s effects in a lab setting. They introduced it into diseased lung cells from COPA patients, and the cells returned to normal function.

Way Ahead

Shum believes HAQ-STING could lead to game-changing treatments, including:

• Prenatal gene therapy for babies diagnosed with COPA Syndrome before birth
• Aerosol delivery of HAQ-STING for adults, directly targeting the lungs

Before publishing their findings, Shum called Betty with the news—her own HAQ-STING gene had protected her from the disease. He also informed Letasha and Kristina, who were overwhelmed with relief and joy.

“We always believed Dr. Shum would get to the bottom of it,” said Letasha. “This discovery is going to change lives.”

The World Health Organization (WHO) noted that menopause often goes unnoticed as a clinical priority, observing these unmet needs, the state governments in Maharashtra and Kerala will soon launch government-run menopause clinics. These clinics will have specialized support systems designed to offer holistic healthcare services for menopausal women within the public system.

These clinics will also have medical consultations, mental health counselling, targeted screening services and lifestyle guidance.

What Are Menopause Clinics?

Menopause clinics are specialized healthcare units, usually housed in government hospitals, urban health centres or district hospitals, that focus on both the medical and emotional needs of women transitioning through menopause. Rather than brushing menopause aside as a “natural” phase that needs little attention, these clinics offer organized, evidence-based care that goes well beyond routine outpatient visits.

At the heart of a menopause clinic is a comprehensive, integrated approach that includes:

• Clinical assessment of menopausal symptoms
• Screening for hormonal and physical health issues, such as bone health and heart disease risk
• Mental health support and psychosocial counselling
• Personalized advice on lifestyle, nutrition and mid-life wellness
• Ongoing patient education and structured follow-up

By bringing these services together under one roof, menopause clinics help women cope with day-to-day symptoms while also addressing long-term risks like osteoporosis, metabolic changes and a higher likelihood of cardiovascular disease.

What Is Menopause?

This is the natural, permanent end of menstruation defined as 12 consecutive months without a period. This typically occurs between ages 45 to 55.

Foods That May Help During Menopause

• Soy: A top source of phytoestrogens, particularly isoflavones, which bind to estrogen receptors in your body. Studies suggest soy may help alleviate hot flashes, improve cholesterol levels, and even reduce the risk of heart disease during menopause.
• Flaxseed: Packed with lignans, a type of phytoestrogen with mild estrogenic effects, flaxseed may also offer some relief.

Including these foods in your diet could help ease symptoms and reduce your risk of certain menopause-related conditions.

Why a Balanced Diet Matters

A nutrient-packed, balanced diet is the foundation of good health at any age. Prioritize:

• Vegetables and fruits: Rich in vitamins and antioxidants.
• Whole grains: Great for maintaining steady blood sugar levels.
• Lean proteins: Support muscle health and repair.
• Low-fat dairy: Provides calcium for bone strength.
• Avoid ultra-processed junk foods, excessive sugar, and unhealthy fats, which contribute little beyond empty calories.

Maharashtra Menopause Clinic

Earlier this January, the Maharashtra government rolled out the country’s first state-run menopause clinics across government hospitals and urban health facilities. The initiative was launched on Makar Sankranti, January 14, under the guidance of Minister of State for Health Meghna Bordikar.

As per official statements, these clinics are designed to offer end-to-end care in one place. Services include expert medical consultations to evaluate and manage menopausal symptoms, mental health support to address emotional and psychological concerns, and screenings for bone health, cardiovascular risk and hormonal balance. Medicines and follow-up advice are also provided during the same visit, cutting down the need for multiple referrals and repeat hospital trips.

A senior health official pointed out that while menopause is a natural life stage and not a disease, many women need consistent physical and emotional support during this transition. The strong response from women across Maharashtra highlights a long-standing gap in healthcare, where menopause-related concerns often went unaddressed due to the absence of dedicated services. With this move, Maharashtra has also set an example for other states looking to introduce gender-specific care within public health systems.

Read: Can Your Diet Affect Menopause?

Kerala follows with dedicated clinics

Taking a cue from Maharashtra, the Kerala government has announced plans to set up specialized menopause clinics in district hospitals. An initial allocation of Rs 3 crore has been earmarked for the project in the 2026 state budget, presented by Finance Minister K N Balagopal.

The proposed clinics in Kerala will follow a similar model, offering medical consultations for menopausal symptoms, mental health counselling, and screenings for heart, bone and hormonal health. Women will also receive medicines along with lifestyle and dietary advice at a single facility.

The initiative acknowledges the wide-ranging impact of menopause, including hormonal changes, sleep disturbances, bone health issues and increased stress, and aims to create a one-stop support system within district hospitals. By bringing menopause care into mainstream public healthcare, Kerala hopes to improve access, reduce stigma and ensure that women receive timely, structured support during this phase of life.

Bruce Willis was diagnosed with frontotemporal dementia in 2022. His wife, Emma Heming Willis recalled the day when Bruce was diagnosed with the condition and how it made her feel "lost, isolated and afraid." Talkin to PEOPLE, Emma said, Bruce "never connected the dots" that he has been diagnosed with frontotemporal dementia. “I think that's like the blessing and the curse of this, is that he never connected the dots that he had this disease, and I'm really happy about that. I'm really happy that he doesn't know about it,” she shared about Bruce, 70.

Bruce Willis' Diagnosis

"On the day Bruce got his diagnosis, we walked out of the doctor's office with a pamphlet and an empty goodbye. No plan, no guidance, no hope, just shock," she explained in front of a packed auditorium, People reported.

In one instant, the family's future disappeared. The Oscar-winning actor, famous for his quick wit and performances in Die Hard and The Sixth Sense, would be leaving his career behind. Emma found herself thrust into a whole new role of full-time caregiver at the same time.

She continued to explain, "I found myself having to keep my family intact, raise our two small girls, and tend to the man that I love while dealing with an illness I hardly knew anything about."

Emma's emotional candor resonated with hundreds of families who have received similar diagnoses and encouraged her to author a book, The Unexpected Journey, scheduled for publication in September. In Emma's words, "This is the book I hope will assist the next caregiver. It is packed with encouragement, wisdom, and the encouragement necessary to walk this path.

Read: Bruce Willis’ Dementia Diagnosis Left Wife Emma Heming Feeling ‘Lost’ And ‘Isolated’ - What Are The Signs Of Caregivers Burnout?

What Is Frontotemporal Dementia?

Frontotemporal dementia is a less prevalent type of dementia that mainly occurs in the frontal and temporal lobes of the brain. It tends to affect behavior, personality, language, and movement more than memory, particularly in its initial stages.

In contrast to Alzheimer's, which generally strikes older individuals, FTD can hit at an earlier age—sometimes as young as 40. The symptoms can range from changes in personality, emotional flatness, or the inability to show empathy to impulsiveness, so it is especially hard for spouses and children to cope.

Emma's case illustrates how abrupt and disrupting this diagnosis can be—not only for the patient but for caregivers as well.

Whereas Bruce Willis' diagnosis hit global headlines, the mental toll taken by Emma, his caregiver, was largely in the background—until she decided to come forward.

Caregiving is a respectable position, but it's also a challenging and thankless one. For those who are caring for loved ones with dementia or other chronic illnesses, the stress of "keeping it all together" can result in a condition called caregiver burnout.

"Caring for someone is the most intimate and demanding work of love," Emma explained, "but when you're not noticed or supported, it begins to undermine your health—mentally and physically."

Work stress could make you gay, said a Malaysian minister Zulkifli Hasan, as continued government intervention of what is described as 'sexually deviant behavior' has pressured the country's LGBTQ community. This happened two weeks after religious authorities and police acted on complaints from a sultan and Islamist politicians that a camping retreat was promoting the LGBTQ lifestyle, reported South China Morning Post.

Religious Affairs Minister Hasan on Tuesday said that work stress could be among many other factors that is pushing people into sexual orientations other than heterosexuality. “Societal influence, sexual experiences, work stress and other personal factors come under this category [of possible causes],” Zulkifli said in a written parliamentary reply to a question by Siti Zailah Mohd Yusoff, a lawmaker with the opposition Islamist party PAS.

Also Read: Andy Kershaw Diagnosed With Spinal Cancer That Left Him Unable To Walk

He cited a 2017 study by Sulaiman et.al., that said such elements "can contribute to the increase in LGBT acts".

His comments have attracted a lot of backlash, with many people on social media mocking him. A social media user Muaz Zam said, "By this logic, I am genuinely shocked my entire office isn't gay by now". Another one read: "In other words: they never work hard in the parliament."

However, these claims are not scientifically back. Work related stress can impact a person, but cannot change their sexuality. It can, however, cause health effects. What it does not do is change one's sexuality and this is why one should know the difference about gender, sex and sexual orientation or sexuality.

'Work Stress Makes You Gay': The Difference Between Gender vs Sex

While these both terms are often used interchangeably in official forms, there is a difference between the two.

As per the Council of Europe, gender is an area that cuts across thinking about society, law, politics, and culture.

Read: Trump Administration Deadnames Transgender Former HHS Officer Rachel Levine in Official Portrait

Definition Of Gender vs Sex by WHO

The World Health Organization notes that sex refers to: "the different biological and physiological characteristics of males and females, such as reproductive organs, chromosomes, hormones, etc.”

Whereas, gender refers to: "the socially constructed characteristics of women and men – such as norms, roles and relationships of and between groups of women and men. It varies from society to society and can be changed. The concept of gender includes five important elements: relational, hierarchical, historical, contextual and institutional. While most people are born either male or female, they are taught appropriate norms and behaviours – including how they should interact with others of the same or opposite sex within households, communities and work places. When individuals or groups do not “fit” established gender norms they often face stigma, discriminatory practices or social exclusion – all of which adversely affect health."

Definition Of Gender vs Sex by The European Institute For Gender Equality

“Sex refers to the biological and physiological characteristics that define humans as female or male. These sets of biological characteristics are not mutually exclusive, as there are individuals who possess both, but these characteristics tend to differentiate humans as females or males.”

“Gender refers to the social attributes and opportunities associated with being female and male and to the relationships between women and men and girls and boys, as well as to the relations between women and those between men. These attributes, opportunities and relationships are socially constructed and are learned through socialisation processes. They are context- and time-specific, and changeable. Gender determines what is expected, allowed and valued in a woman or a man in a given context. In most societies, there are differences and inequalities between women and men in responsibilities assigned, activities undertaken, access to and control over resources, as well as decision-making opportunities. Gender is part of the broader sociocultural context. Other important criteria for sociocultural analysis include class, race, poverty level, ethnic group and age.”

The main difference is that gender is a social construct, whereas sex is the biologically labelled term based on organs and hormones.

Read More: Trump's Top Health Nominee Wants ‘Corrective Care’ For Trans People

What Is Sexuality?

As per the American Psychological Association (APA), sexuality is the capacity to derive pleasure from various forms of sexual activity and behavior. The Lanarkshire Sexual Health describes sexual orientation as a way to describe the feelings you have for someone you fancy or are attached to.

While sexuality can change overtime, it is not a choice. There is no evidence that sexual orientation can be forced to change through therapy.

Can Stress Impact Sexuality?

While stress can impact sexual function by reducing libido, causing fatigue, and triggering hormonal changes, it does not change one's sexual orientation. Jason Teoh, who writes on LGBTQ issues, project partner at NSW Department of Planning, Housing and Infrastructure, notes: "Sexual orientation is not caused by stress. It is not caused by trauma, influence or difficult life circumstances."

The WHO notes: sexual orientation is a natural, stable part of human identity shaped by biology, genetics, and early development. The WHO removed homosexuality from its disease classification in 1990. The American Psychiatric Association did the same in 1973.