Ishita Roy

Why More People Are At Risk Of Alzheimer's And Dementia?

Dementia and Alzheimer's Disease

As per a new <span>study</span> published in the journal Nature, it has been revealed that some brain cells are more susceptible to aging and its affects as compared to others. This study is said to shed new light on why some people are at more risk for <span><a href="https://www.healthandme.com/health/dementia">dementia</a></span>, <span><a href="https://www.healthandme.com/health/alzheimers-disease">Alzheimer's disease</a></span> and other such brain disorders as their age increase as compared to others. 

“Aging is the most important risk factor for Alzheimer’s disease and many other devastating brain disorders. These results provide a highly detailed map for which brain cells may be most affected by aging,” Dr. Richard Hodes, director of the National Institute on Aging.

“This new map may fundamentally alter the way scientists think about how aging affects the brain and also provide a guide for developing new treatments for aging-related brain diseases,” Hodes added.

The study was conducted on mice and an advanced genetic analysis was used. With the help of that researchers compared individual cells in the brains of 2 month old "young" and 18 month old "senior" mice. The scientists then looked at the genetic activity of cell types located in 16 different regions constituting 35% of the total volume of mouse brain. 

Researchers found that aging tends to decrease activity in genes associated with brain cells. For instance, aging reduced development of newborn neurons in at least 3 different parts of the brain. These parts include neurons associated with learning and memory. 

Also, it was found that aging increased the activity of genes associated with immune and inflammatory functions. 

Cells that were more sensitive to aging also appeared to surround the third ventricle, a major pipeline that enables spinal fluid to pass through a brain region called the hypothalamus. This region produces hormones that control body functions like maintaining a certain body temperature, heart rate, sleep, thirst, and hunger. 

Some of these observations also matched with the previously done studies that linked aging with metabolism. Researchers explained that intermittent fasting and other calorie-restrictive diets have been shown to increase life span. This could be explained by the age sensitive neurons which were found in the hypothalamus producing hormones, which also control hunger and energy production. 

“This study shows that examining the brain more globally can provide scientists with fresh insights on how the brain ages and how neurodegenerative diseases may disrupt normal aging activity,” John Ngai, director of the National Institutes of Health’s Brain Research Through Advancing Innovative Neurotechnologies initiative, said in a news release.

<h4>What Is <span rel="noindex">Alzheimer's</span> or Dementia?</h4>

<a href="https://www.healthandme.com/health-news/world-alzheimers-day-history-significance-and-dementia-awareness-article-151040350" data-type="tilCustomLink">Alzheimer's</a> is a severe brain disorder of memory loss and confusion. If it is not diagnosed and managed on time, it can also adversely impact one's mental abilities of learning, thinking, reasoning, remembering, problem-solving, decision-making, and attention.

Whereas Dementia is an umbrella term to describe diseases that cause people to lose their cognitive functions. These diseases gradually progress decreasing the ability for someone to function in daily life and take care of themselves. There are some medications used to delay the onset of it and to manage it. People can reduce the chances of developing it by following a healthy diet and lifestyle.

Health Conditions A-Z

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Alzheimer's Disease

Dementia

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cognitive decline

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As per a new study published in the journal Nature, it has been revealed that some brain cells are more susceptible to aging and its affects as compared to others. This study is said to shed new light on why some people are at more risk for dementia, Alzheimer's disease and other such brain disorders as their age increase as compared to others. “Aging is the most important risk factor for Alzheimer’s disease and many other devastating brain disorders. These results provide a highly detailed map for which brain cells may be most affected by aging,” Dr. Richard Hodes, director of the National Institute on Aging.“This new map may fundamentally alter the way scientists think about how aging affects the brain and also provide a guide for developing new treatments for aging-related brain diseases,” Hodes added.How Was The Study Conducted?The study was conducted on mice and an advanced genetic analysis was used. With the help of that researchers compared individual cells in the brains of 2 month old "young" and 18 month old "senior" mice. The scientists then looked at the genetic activity of cell types located in 16 different regions constituting 35% of the total volume of mouse brain. What Did The Study Find?Researchers found that aging tends to decrease activity in genes associated with brain cells. For instance, aging reduced development of newborn neurons in at least 3 different parts of the brain. These parts include neurons associated with learning and memory. Also, it was found that aging increased the activity of genes associated with immune and inflammatory functions. Cells that were more sensitive to aging also appeared to surround the third ventricle, a major pipeline that enables spinal fluid to pass through a brain region called the hypothalamus. This region produces hormones that control body functions like maintaining a certain body temperature, heart rate, sleep, thirst, and hunger. Some of these observations also matched with the previously done studies that linked aging with metabolism. Researchers explained that intermittent fasting and other calorie-restrictive diets have been shown to increase life span. This could be explained by the age sensitive neurons which were found in the hypothalamus producing hormones, which also control hunger and energy production. “This study shows that examining the brain more globally can provide scientists with fresh insights on how the brain ages and how neurodegenerative diseases may disrupt normal aging activity,” John Ngai, director of the National Institutes of Health’s Brain Research Through Advancing Innovative Neurotechnologies initiative, said in a news release.What Is Alzheimer's or Dementia?Alzheimer's is a severe brain disorder of memory loss and confusion. If it is not diagnosed and managed on time, it can also adversely impact one's mental abilities of learning, thinking, reasoning, remembering, problem-solving, decision-making, and attention.Whereas Dementia is an umbrella term to describe diseases that cause people to lose their cognitive functions. These diseases gradually progress decreasing the ability for someone to function in daily life and take care of themselves. There are some medications used to delay the onset of it and to manage it. People can reduce the chances of developing it by following a healthy diet and lifestyle.