Have you ever been so tired that the moment you hit the bed, you feel like you are sinking in your mattress? Or did you ever feel your leg twitch in middle of your sleep? Did you feel like you moved your leg to prevent yourself from falling down? If yes, then you are in for a great read!

Why does this happen?

You are not alone, this happens to around 70% of the total population in some way or another. Although these are signs of sleep disorders, it can also happen to people who are otherwise healthy. Sleep disorder specialists believe that there are certain common triggers that leads to such a sensation.

Our brain is exceptional and sometimes when we dream, it makes us believe that we our part of the dream. And if you are falling from somewhere in your dream, chances are, you would feel like you are falling in real life. This experience is known as hypnic jerk, the movement of your muscle that helps you be safe from that fall, or the imaginary one.

What causes it? When we sleep, our bodies become paralyzed, but that does not mean that our muscle control is not totally off. Rather, a slow, dimmer switch. When the dim switch randomly is turned on, we get jerky movements in our sleep.

This involuntary muscle movement is also called myoclonus or hypnic myoclonus, that transitions as you shift from one sleep phase into another.

ALSO SEE: What is sleep paralysis?

What Could Cause It?

There are many theories on what might be causing it. One of them is that when you are at this stage of sleep, you are still not in deep sleep and your brain misinterprets it as wakefulness, however, at the same time your brain does not recognize your muscles to be moving. This is what leads your brain to send a message to your muscles to check-in. It is a way your brain tries to protect you.

Another theory is of course that of stress. When you are stressed, your mind might be racing, while your body is in stationary. This can also affect your sleep cycle and your sleep can be disrupted.

If you are on stimulant drugs or alcohol, it too can prevent you from achieving a good night sleep. If you have consumed too much caffeine then too your muscles can twitch to make you stay awake.

Furthermore, lack of sleep could also be the reason why your mind is used to staying awake even if your body really needs the rest.

Periodic Limb Movement Disorder

While the falling sensation in sleep is quite common, and happens to healthy people, a severe form is the Periodic Limb Movement Disorder (PLMD). PLMD is a repetitive cramping or jerking of legs during sleep. It is a movement disorder that happens only during sleep. It is called "periodic" because the movements are repetitive and rhythmic, which means it occurs in every 20 to 40 seconds. It is also often linked with restless legs syndrome, however, the two are not the same thing.

Restless leg syndrome on the other hand is a condition that involves strange sensations in the legs and arms while awake and an irresistible urge to move the limbs to relive the sensations.

What causes PLMD may be more severe things, including diabetes, iron deficiency, spinal cord tumor, spinal cord injury, sleep apnea, uremia, anemia, narcolepsy, or certain medications.

A newly recognised form of diabetes is reshaping how scientists and doctors view the condition, particularly in countries like India. In 2025, global health authorities officially acknowledged Type 5 diabetes as a separate and distinct form of the disease.

This recognition ended decades of confusion around a type of diabetes that did not fit neatly into the existing categories of Type 1 or Type 2 diabetes. The formal classification, backed by the International Diabetes Federation and supported by research published in The Lancet Global Health, is expected to transform diagnosis, treatment, and long-term care for millions of people worldwide.

But what exactly is Type 5 diabetes, and how does it differ from the types of diabetes that are more widely known?

What Is Type 5 Diabetes?

Type 5 diabetes is now recognised as a distinct form of the disease caused primarily by severe, long-term malnutrition, often experienced during childhood. This undernutrition can lead to profound insulin deficiency and an underdeveloped pancreas, resulting in significantly reduced insulin production.

Unlike Type 1 diabetes, which is autoimmune, or Type 2 diabetes, which is linked to insulin resistance, Type 5 diabetes arises from nutritional deficiencies that impair the pancreas’s ability to function properly.

It most commonly affects lean young adults in low-income regions. For years, people with this condition were misdiagnosed as having Type 1 diabetes or an unusual form of Type 2, often leading to inappropriate treatments that failed to address the root cause.

Type 5 Diabetes Symptoms

Symptoms of type 5 diabetes can resemble those seen in other forms of diabetes, such as excessive thirst, frequent urination, persistent tiredness, unexplained weight loss, blurred vision, and slow-healing wounds. However, they are often paired with indications of malnutrition, including a lean physique, delayed growth or puberty in young people, anemia, and recurring infections.

These arise from nutritional deficiencies during early life rather than solely from insulin resistance or autoimmune causes, and they usually present before the age of 30, according to the International Diabetes Federation.

Type 5 Diabetes: Scientists Demand Recognition

Researchers have been studying this condition for decades, particularly in parts of Asia and Africa. Yet, without official recognition, the disease remained poorly understood, and patients were rarely diagnosed correctly. Experts argued that grouping these patients under existing categories obscured the true cause of their illness.

The 2025 classification now formally separates Type 5 diabetes from other types, making it easier to study, identify, and manage. In India, where diabetes prevalence is already high, this recognition is particularly relevant. Tens of millions of people live with diabetes in the country, many of whom remain undiagnosed. Type 5 diabetes highlights a different pattern: it develops not from excess calories, but from too little nutrition during childhood, creating a double burden in regions where obesity and undernutrition coexist.

Implications for Diagnosis and Care

Although there is no new treatment specifically for Type 5 diabetes yet, official recognition marks a major step forward. Doctors can now approach lean patients with a history of malnutrition more carefully, avoiding a “one-size-fits-all” approach. Clearer classification could lead to better guidelines, more personalised care, fewer complications, and improved long-term outcomes.

Experts believe that understanding the role of childhood undernutrition in diabetes could eventually reshape how we prevent, monitor, and manage the condition—something countries like India urgently need as diabetes numbers continue to rise.

An early sign of dementia can sometimes look like a common winter-related issue. When this symptom appears along with other warning signals, it may be wise to speak to a doctor. Dementia is a syndrome marked by a collection of related symptoms that point to a gradual decline in brain function. Over time, this can affect memory, behaviour, thinking, and even movement. In its early phase, however, dementia often shows up through subtle changes that are easy to overlook or mistake for something less serious.

This Common Cold Like Symptom Might Actually Be An Early Sign of Dementia

Dementia UK notes that one possible early indicator of dementia is “low mood, anxiety or depression”. Its specialists explain: “In the early stages of dementia, people often begin to notice symptoms that interfere with day-to-day life.” The difficulty is that low mood or depression can also be linked to seasonal affective disorder (SAD), a form of depression that tends to appear during winter and ease as the days become longer and brighter.

Symptoms of Seasonal Affective Disorder (SAD)

The NHS lists the following possible symptoms of SAD:

• Low mood
• Loss of interest in activities you usually enjoy
• Feelings of guilt, hopelessness or worthlessness
• Feeling restless, tense or easily irritated
• Problems with concentration
• Increased appetite and eating more than usual
• Feeling very tired and sleeping more than usual
• Thoughts of suicide or self-harm

Dementia Early Symptoms

• Problems with memory and concentration
• Difficulties with language and communication, such as struggling to find words or follow conversations
• Difficulties with planning, problem-solving and making decisions
• Getting lost in familiar places because of problems with orientation and reduced ability to recognise usual cues, such as signs or landmarks
• Changes in behaviour and personality, such as becoming more withdrawn or less patient

How Early Symptoms May Differ Between Dementia Types

The organisation explains: “A person experiencing early symptoms of dementia may notice these changes themselves, or they may be picked up first by family members, friends or colleagues. Memory problems are not always obvious in the early stages of some types of dementia, such as frontotemporal dementia, where changes in behaviour and personality may appear first.

“People with young onset dementia, where symptoms begin before the age of 65, are also less likely to have memory loss as an early symptom.”

Emotional Changes Linked To Specific Forms Of Dementia

The charity also points out that emotional changes can be linked to two specific types of dementia. In vascular dementia, a person may experience “changes in mood, behaviour and personality”, while Lewy body dementia can cause “mood changes, including anxiety and depression”.

Dementia: Why These Symptoms Can Be Hard To Identify

That said, it is often difficult to know at first whether dementia is the cause of these warning signs. Dementia UK advises: “Many symptoms associated with dementia can also be caused by other physical or mental health conditions, such as thyroid disorders, menopause, vitamin B12 deficiency, depression, anxiety, work-related stress or relationship difficulties.

“This means that experiencing symptoms linked to dementia does not automatically mean someone has the condition. However, if you or someone close to you is showing signs or symptoms of dementia, it is important to visit a GP to understand what might be causing them.”

When To Seek Medical Advice

If you or someone you know is showing symptoms that resemble dementia, seeking advice from your GP is an important first step.

Gonorrhea poses a far more serious challenge than many realise. Over the years, doctors treating the infection have seen their treatment choices steadily shrink. The bacteria responsible, Neisseria gonorrhoeae, has repeatedly adapted to antibiotics, rendering many once-reliable drugs ineffective. As a result, clinicians have been forced to depend heavily on a single injectable medication, a situation that has raised growing concern.

That dependence is becoming increasingly risky. Data from the US Centers for Disease Control and Prevention show that reported cases of gonorrhea, chlamydia, and syphilis have climbed by nearly 90% since 2004. In 2023 alone, the country recorded more than 2.4 million cases of sexually transmitted infections.

FDA Clears First New Gonorrhea Drug In 30 Years

This month, however, marked a significant shift. The US Food and Drug Administration approved two new oral antibiotics to treat gonorrhea: zoliflodacin and gepotidacin. These approvals represent the first entirely new gonorrhea treatments in more than three decades.

“These approvals mark a significant milestone for treatment options for patients with uncomplicated urogenital gonorrhea,” said Dr Adam Sherwat of the FDA in an official statement.

Why Gonorrhea Has Become Harder to Treat

If left untreated, gonorrhea can lead to serious complications, including pelvic inflammatory disease, infertility, and in rare cases, infections that spread to the joints or bloodstream, as per Cleveland Clinic. Many people experience no symptoms at all, allowing the infection to spread quietly. Despite years of research, there is still no licensed vaccine, leaving antibiotics as the primary line of defence.

What the FDA’s Decision Changes

The newly approved treatments offer a fresh sense of hope. Zoliflodacin, developed by the nonprofit Global Antibiotic Research and Development Partnership in collaboration with Innoviva Specialty Therapeutics, is designed as a single-dose oral medication. Gepotidacin, developed by GSK, is taken in two doses and is also approved for treating certain urinary tract infections.

Both medicines eliminate the need for injections, a shift that could make treatment simpler and more accessible, particularly in settings where access to clinics is limited.

FDA Clears First New Gonorrhea Drug: How the Two New Medicines Work

As per Medscape, clinical trial results for both drugs have been encouraging. Zoliflodacin was tested in a large international study involving more than 900 participants across Europe, Africa, Asia, and the US. The drug successfully cured about 90.9% of patients, a rate comparable to the 96.2% success rate of the current injectable standard. Most reported side effects were mild.

Gepotidacin showed similarly strong results in a separate Phase 3 trial that included around 600 patients from six countries. The cure rate reached 92.6%. Some participants reported digestive issues, but these effects were generally described as mild.

What the Trial Results Show

Importantly, both medications were effective against strains of gonorrhea that no longer respond to older antibiotics. That said, public health experts stress that these drugs are not a permanent solution.

“Bacteria are smart. They can pass resistant mechanisms between each other,” said Dr Manica Balasegaram of the Global Antibiotic Research and Development Partnership, speaking to CNN.

Why Experts Say Caution Is Still Needed

Several uncertainties remain. Neither drug has yet shown strong effectiveness against throat infections, known as pharyngeal gonorrhea, which are more difficult to detect and treat. There is also ongoing debate about how best to use the new medications. Some experts argue they should be reserved as last-line treatments, while others believe earlier use could help slow resistance.

Dr Tereza Kasaeva of the World Health Organization described the approvals as “an important and timely development” amid rising global infection rates and limited treatment options, according to The Guardian.

For now, the new drugs provide much-needed breathing room. Whether that progress holds will depend on careful prescribing and close monitoring of how resistance evolves.