Have you ever been so tired that the moment you hit the bed, you feel like you are sinking in your mattress? Or did you ever feel your leg twitch in middle of your sleep? Did you feel like you moved your leg to prevent yourself from falling down? If yes, then you are in for a great read!

Why does this happen?

You are not alone, this happens to around 70% of the total population in some way or another. Although these are signs of sleep disorders, it can also happen to people who are otherwise healthy. Sleep disorder specialists believe that there are certain common triggers that leads to such a sensation.

Our brain is exceptional and sometimes when we dream, it makes us believe that we our part of the dream. And if you are falling from somewhere in your dream, chances are, you would feel like you are falling in real life. This experience is known as hypnic jerk, the movement of your muscle that helps you be safe from that fall, or the imaginary one.

What causes it? When we sleep, our bodies become paralyzed, but that does not mean that our muscle control is not totally off. Rather, a slow, dimmer switch. When the dim switch randomly is turned on, we get jerky movements in our sleep.

This involuntary muscle movement is also called myoclonus or hypnic myoclonus, that transitions as you shift from one sleep phase into another.

ALSO SEE: What is sleep paralysis?

What Could Cause It?

There are many theories on what might be causing it. One of them is that when you are at this stage of sleep, you are still not in deep sleep and your brain misinterprets it as wakefulness, however, at the same time your brain does not recognize your muscles to be moving. This is what leads your brain to send a message to your muscles to check-in. It is a way your brain tries to protect you.

Another theory is of course that of stress. When you are stressed, your mind might be racing, while your body is in stationary. This can also affect your sleep cycle and your sleep can be disrupted.

If you are on stimulant drugs or alcohol, it too can prevent you from achieving a good night sleep. If you have consumed too much caffeine then too your muscles can twitch to make you stay awake.

Furthermore, lack of sleep could also be the reason why your mind is used to staying awake even if your body really needs the rest.

Periodic Limb Movement Disorder

While the falling sensation in sleep is quite common, and happens to healthy people, a severe form is the Periodic Limb Movement Disorder (PLMD). PLMD is a repetitive cramping or jerking of legs during sleep. It is a movement disorder that happens only during sleep. It is called "periodic" because the movements are repetitive and rhythmic, which means it occurs in every 20 to 40 seconds. It is also often linked with restless legs syndrome, however, the two are not the same thing.

Restless leg syndrome on the other hand is a condition that involves strange sensations in the legs and arms while awake and an irresistible urge to move the limbs to relive the sensations.

What causes PLMD may be more severe things, including diabetes, iron deficiency, spinal cord tumor, spinal cord injury, sleep apnea, uremia, anemia, narcolepsy, or certain medications.

In a significant step toward advancing xenotransplantation—the transplantation of organs or tissues from animals into humans—in India, a dedicated department has been established, with research and regulatory work underway. The country’s first animal-to-human organ transplant could follow, subject to government approval and the establishment of legal and ethical guidelines.

The initiative aims to help bridge the organ shortage in the country, Dr. Shikhar Tripathi, Director of the Department of Xenotransplantation Sciences at Sir Ganga Ram Hospital, New Delhi, helming the project, told HealthandMe.

Dr. Tripathi, who has trained with Dr. David K. C. Cooper, a British surgeon-scientist and pioneer of modern xenotransplantation, believes India could perform its first xenotransplant within six months of receiving government permission.

The push comes as xenotransplantation continues to make progress internationally. In 2025, a patient received a genetically engineered pig kidney and lived without dialysis for 271 days before subsequently receiving a human kidney transplant.

India recorded 20,138 organ transplants in 2025, ranking third globally. However, the gap between the demand for and supply of organs remains significant, with deceased-donor donations accounting for a small share of transplants.

Dr. Tripathi estimates India’s annual organ shortage at around 90,000. According to data reported by hospitals and transplant centers on the National Organ and Tissue Transplant Organization (NOTTO) National Registry Portal, the waiting list for major organs stood at 89,839 as of March 3, 2026.

Kidneys accounted for the largest share of patients on the waiting list, followed by livers, hearts, lungs and pancreases.

In an interview with HealthandMe, Dr. Tripathi, who is also working with Dr. Cooper at the Thomas E. Starzl Transplantation Institute in Pittsburgh, US, discussed the scientific barriers, infection risks, regulatory requirements and potential of xenotransplantation in India.

Q. A pig kidney functioned for 271 days without dialysis in a human. What does this milestone mean for xenotransplantation?

Dr. Shikhar Tripathi: Xenotransplantation has achieved significant milestones, but researchers are still working toward long-term viability. For now, it could serve as a bridge for patients who need an organ while researchers work to address complications and improve graft survival.

“Xenotransplantation has achieved some really significant milestones in the last year or so.”

Q. What are the main barriers to long-term survival of a transplanted animal organ?

Dr. Tripathi: Genetic engineering has helped researchers modify the pig genome to reduce the risk of early rejection. The challenge now is managing late complications, particularly in kidney xenotransplantation.

Two major concerns are proteinuria, or leakage of proteins through the kidney, and thrombotic microangiopathy (TMA), which involves injury to microscopic blood vessels.

“The current barrier we face is late complications of xenotransplantation.”

He added that his group has published research identifying potential pathways involved in proteinuria and TMA and is investigating ways to address these complications.

Q. What are the infection risks associated with xenotransplantation, and why is lifelong monitoring important?

Dr. Tripathi: One concern is zoonosis, or the transmission of infection from an animal or animal organ to a human. Genetic modifications are intended to address this risk.

“There have been as many as 69 gene edits that have been done by eGenesis,” he said, referring to the company developing genetically engineered organs for transplantation.

Dr. Tripathi believes the risk of zoonotic infection is minimal, but this does not eliminate the risk of infection. Patients also face infections associated with immunosuppression, which is used to prevent their immune systems from rejecting a transplanted organ.

Dr. Tripathi’s group is also working toward accommodation and tolerance, which could allow transplanted organs to function with less immunosuppression.

He said lifelong monitoring of recipients will be needed to track outcomes and ensure continued medical care.

Q. India continues to face a significant organ shortage. How could xenotransplantation help bridge the gap between demand and supply?

Dr. Tripathi: India’s annual organ shortage is around 90,000, and it is increasing. The challenge is not just finding donors but ensuring they are medically fit and compatible with recipients.

He recalled a case in which an 85-year-old father-in-law was willing to donate a kidney to his daughter-in-law, but his age made him unsuitable, and no other family member was a match.

“The question is not whether you have a donor available. It’s also whether your donor is healthy or not,” he said.

He also raised ethical concerns about dependence on deceased-donor organs, arguing that patients should have alternatives that do not depend on another person’s death.

“I think xenotransplantation is not just going to solve a medical problem. It’s going to solve a moral problem,” he said.

Q. What is Sir Ganga Ram Hospital doing to advance xenotransplantation in India?

Dr. Tripathi: The aim is to carry out the first procedure with scientific support and within the necessary legal and ethical framework.

The team is prepared to move forward once the required guidelines are established and government permission is granted.

Q. How soon could India perform its first xenotransplant, and which type of transplant might reach clinical practice first?

Dr. Tripathi: I believe pancreatic islet-cell xenotransplantation could reach clinical practice before whole-organ transplantation.

Islet cells in the pancreas produce insulin, making them a potential area of research for conditions such as type 1 diabetes.

“It’s my scientific belief that islet-cell xenotransplantation would be the first one to hit the clinics,” he said.

As for India’s first xenotransplant, the timeline depends on government approval. “Potentially, six months from the day of the permission, we can perform the first transplant,” he said.

Q. What scientific, regulatory and biosecurity hurdles must India overcome before its first xenotransplant, and what lessons does the 1997 pig-organ transplant case involving Dr. Dhaniram Baruah in Assam offer today?

Dr. Tripathi: India’s first xenotransplant will have scientific, legal and ethical backing, along with patient consent. He said there was no comparison with the 1997 case involving Dr. Dhaniram Baruah in Assam, in which the patient died seven days after the procedure following multiple infections.

“We will not take a single step out of the legal ambit or the ethical ambit,” he said.

Q. Looking ahead five years, could India become a global leader in xenotransplantation?

Dr. Tripathi: India could play a leading international role. “India will be one of the leaders,” he said.

India can also establish its own xenorgan facilities over the next five to eight years. Until then, transporting organs from overseas companies could be an option, provided a secure transportation system is established in coordination with government authorities.

The Indian Meteorological Department has put the coastal states of Andhra Pradesh and Odisha on high alert as Cyclone Arnab is due to make a landfall on Wednesday forenoon.

The department said that a “very severe” cyclonic storm, named Ornab (Arnab), is forming over the Bay of Bengal, nearly 260 km southeast of the port city of Visakhapatnam, the most populous city in Andhra Pradesh.

Nearly 12 million people live on the cyclone’s projected route, which runs inland and north across India, according to Andhra Pradesh’s disaster management authority.

Out of around 400,000, nearly 50,000 people in vulnerable areas have been evacuated to state-run shelters since Monday, according to Reuters. According to The Hindu, around 48,000 people are being mobilised to safer areas in Odisha.

Health Risks After The Storm

Cyclonic storms do not just end when the winds blow away or floodwater recedes. Floodwater may contain human and animal waste, chemicals and decaying organic matter. This could contaminate drinking water.

Contaminated drinking water, damaged sewage systems and stagnant pools can create conditions for waterborne infections and mosquito-borne diseases in the days and weeks that follow.

Exposure may increase the risk of gastrointestinal infections, while contact with contaminated water can also transmit infections like leptospirosis. Additionally, water collected in puddles and blocked drains can turn into breeding sites for mosquitoes.

Dr Divya K S, infectious disease specialist at Apollo Hospitals, Seshadripuram, Bengaluru, told HealthandMe that the health risks that can emerge after Cyclone Arnab, the warning signs to watch for and the precautions people should take.

Risk Of Water-Borne Infections

One of the biggest post cyclone threats is contamination of drinking water sources. Floodwaters can cross into potable water networks and mix with sewage, allowing disease germs to enter water used for drinking, cooking and washing.

Dr Divya warns of the risk posed by acute enteric pathogens, which can cause gastrointestinal illnesses. “Widespread contamination of municipal water and sewage water can cause an increase in pathogens causing gastroenteritis like Cholera, enteric fever etc.,” she says.

She added, “Floodwater is an active biohazard matrix containing human/animal waste, chemicals, and decaying organic matter.”

According to the expert, exposure to these pathogens could lead to different infections: Acute Diarrheal Pathogens: Vibrio cholerae, enterotoxigenic E. coli (ETEC), Salmonella enterica, Shigella spp., Campylobacter, and enteric viruses (Rotavirus, Norovirus) causing acute watery diarrhea and inflammatory dysentery. Leptospirosis: Leptospira shed in rodent urine can penetrate abrasions or mucous membranes.

Contaminated water and food can transmit infections like cholera, enteric fever and other infections like dysentery. Enteric viruses, including norovirus and rotavirus, can also cause diarrhoea.

Symptoms may include diarrhoea, vomiting, abdominal cramps and fever. Severe diarrhoea can lead to dehydration, which is particularly dangerous for young children, older adults and people with underlying health conditions.

People should seek medical attention if they develop bloody diarrhoea, vomiting, severe abdominal pain, high fever, confusion, or other signs of severe dehydration.

Also read: Scrub Typhus Claims 15 Lives In Rajasthan: What To Know About Its Symptoms, Transmission, Treatment & Prevention

Risk Of Vector-Borne Infections

As floodwaters recede, water may collect in puddles, blocked drains and other neglected spaces. These sites can cause mosquito breeding, increasing the risk of diseases like dengue, chikungunya and malaria.

Dr Divya says, “Vector populations surge sharply within 1 to 2 weeks post-cyclone. As floodwaters recede, micro-environments like puddles, discarded containers form ideal sites for mosquito breeding.”

After a cyclone, it is therefore important to remove breeding sites by clearing out stagnant water. Residents should empty discard containers that collect water, clear blocked drains, and avoid water accumulation around their homes.

Also read: Climate Change And Gut Health: How Heat, Drought And Unsafe Water Raise Risks, Global Experts Warn

Who Is The Most Vulnerable After A Storm?

Some people face a higher risk of severe complications because of their age, health conditions or difficulty accessing medical care. Dr Divya identifies the following groups as particularly vulnerable:

• Immunocompromised people: Those with advanced HIV, cancer patients receiving chemotherapy, transplant recipients and people taking immunosuppressive medicines.
• Children and older adults: Both groups may be more vulnerable to dehydration and severe illness.
• Pregnant women: Infections and disruptions in maternity care can pose additional risks.
• People with chronic conditions: Those with diabetes, chronic kidney disease or cardiovascular disease may need uninterrupted access to treatment.

During evacuation, people must carry emergency medicines. Insulin and other temperature-controlled medicines need appropriate storage, while people receiving dialysis, chemotherapy or care related to transplant may need urgent arrangements if services are disrupted.

Pregnant women should continue to access antenatal care and seek urgent help for warning signs like bleeding, severe abdominal pain or reduced fetal movement later in pregnancy.

How To Protect Yourself After The Storm?

Safe drinking water, hand hygiene and food safety are essential after a cyclone, especially when sanitation infrastructure has been damaged.

Dr Divya recommends boiling water to make it safer to drink. “Boiling water can ensure disinfection of the water borne infections,” she says.

The doctor also emphasises hand hygiene and safe food practices. “Rigorous hand hygiene using soap and water prior to food consumption and post-defecation,” she recommends.

Food should be thoroughly cooked and served hot. Avoid raw produce that cannot be washed, food exposed to flies and meals whose handling or storage conditions are unsafe.

Women with long COVID had just over twice the risk of receiving a cardiovascular diagnosis compared with women without long COVID, according to a study.

The study from Karolinska Institutet, published in eClinicalMedicine, showed that men with long COVID had approximately a third higher risk.

The increased risk was also observed among people who had mild infections and did not require hospitalization.

“Our results show that long COVID can be a risk factor for cardiovascular disease, even in younger people who were previously healthy. This underlines the need for structured follow-up that takes gender differences into account, particularly as cardiovascular disease in women often presents with more diffuse symptoms that can make diagnosis more difficult,” said lead author Pia Lindberg, a nurse and PhD student at the Department of Medicine, Solna, Karolinska Institutet.

Long COVID Linked To Higher Risk Of Cardiovascular Events

Also read: New Heart Health Guidance For Women: Heavy Periods, Pregnancy Complications May Signal Heart Disease Risk

The results showed that the risk of conditions such as cardiac arrhythmias and coronary artery disease was higher even among people who were not hospitalized during the acute infection.

Of the just over 1.2 million people aged between 18 and 65 included in the study, around 9,000 had been diagnosed with long COVID, corresponding to 0.7%. Two-thirds of them were women. People who had previously had cardiovascular disease or been hospitalized for COVID-19 were excluded from this group.

During the follow-up period of around four years, people with long COVID were more likely to experience cardiovascular events. These occurred in 18.2% of women and 20.6% of men with long COVID, compared with 8.4% of women and 11.1% of men without long COVID.

“We found that cardiac arrhythmias and coronary artery disease were more common among both women and men with long COVID. In women, there was also an increased risk of heart failure and peripheral vascular disease. However, no clear association was found between long COVID and stroke,” said Lindberg.

Why Long COVID Patients Need Systematic Monitoring

Read More: Long COVID: Mouth And Lung Bacteria May Offer Clues

As many people with long COVID never required hospitalization during their acute infection, there is a risk that secondary conditions may be missed, Lindberg said, pointing out that the results suggest these patients may need to be monitored more systematically.

Long COVID has become an increasingly significant health problem worldwide, and a growing number of studies suggest that the condition can lead to secondary cardiovascular diseases. To date, research has mainly focused on people who were hospitalized, while the risks for those who stayed at home or were treated by a general practitioner are less well known.

In the current study, the researchers investigated how often major cardiovascular events occurred in people with long COVID compared with those without the diagnosis.

What Is Long COVID?

Long COVID refers to new, returning or ongoing health problems that persist four or more weeks after the initial COVID-19 infection. Symptoms can last for months or even years.

Common symptoms include fatigue, brain fog, memory problems, difficulty concentrating and slowed thinking.

Research has also suggested that brain inflammation may persist even after the virus is no longer detectable.