Ozempic and Wegovy have received a lot of publicity as revolutionizing treatment options for obesity. Both medications form a class of GLP-1 receptor agonists, which mimic a hormone in the body called glucagon-like peptide-1 and are involved in the regulation of appetite and blood sugar. Indeed, in initial clinical studies, the majority of those on the drugs lost 15% to 22% of body weight, hence much optimism. For most patients, these medications are underwhelming for about 20% of patients due to minimal weight loss or other challenges.

Take a closer look at why the weight loss drugs may not work for everyone, together with what options exist when they don't deliver the expected outcomes.

Why Weight Loss Drugs May Not Work

While GLP-1 receptor agonists have produced phenomenal responses in a majority of patients, it remains a reality that these drugs work differently for different people. Here's why:

1. Genetic and Hormonal Variability

Weight loss medications interact with complex systems in the body that differ from person to person. Genetics, hormones, and individual brain responses to energy regulation play significant roles in determining how a person responds to drugs like Ozempic and Wegovy.

2. Underlying Medical Conditions

Other conditions, such as sleep apnea, may be prevalent and prevent or delay the achievement of weight loss goals. Prescription drugs like antidepressants, steroids, or contraceptives are other medications that can nullify weight loss medication benefits.

3. Unrealistic Expectations

Often, they come to these medications with enormous hopes; expecting the promised rapid and dramatic weight loss. Progress creates disappointment if it has not stalled. In patients who rigidly follow recommended lifestyle modifications, frustration and disappointment are most common.

Why it is Important to Identify Non-responders

For most patients, the effectiveness of GLP-1 receptor agonists is evident within a few weeks of treatment. Weight loss typically begins within a few weeks of initiating therapy and tends to increase with dosage. However, some patients respond very little, if at all, despite strict adherence to their regimen.

For nonresponders, this can feel like a dead end. However, understanding the unique complexities of obesity is essential. This condition stems from brain dysfunction, and the pathways that contribute to weight regulation differ among individuals.

Alternative Treatment Options

When Ozempic or Wegovy doesn’t yield desired results, there are still many paths to explore:

1. Switching to Another GLP-1 Drug

For example, some patients who don't respond well to one GLP-1 receptor agonist might find success with another drug in the same class. Newer medications, such as Zepbound, target other hormone pathways and seem promising even for those not responsive to earlier drugs.

2. Use of Older Medications

While there is much to say about newer drugs, older treatments can still be useful and work for some patients. One can also seek the help of a medical provider specializing in obesity treatments in order to identify the best alternatives.

3. Lifestyle Changes

Diet, exercise, sleep, and stress management continue to be integral components of any weight loss program. New changes may be small but can make an enormous difference in one's health and success.

4. Medical Management of Obesity

It is a complex disorder, and most patients should receive a multidisciplinary treatment. Collaboration with an obesity-aware doctor may mean access to tailored treatment plans, ranging from psychological support all the way to metabolic testing, and many others.

Why Side Effects of Weight Loss Drug Ozempic May Be a Barrier

For others, side effects like nausea, vomiting, or diarrhea hinder them from continuing with these drugs. These symptoms often reduce as the body becomes accustomed, but for some, they might be severe enough to stop treatment altogether. In those instances, alternative drugs or procedures become vital to find.

Long-term effects of Ozempic or Wegovy on the Brain

Another largely unexplored area relates to GLP-1 drugs' long-term effects on the brain's regulation of hunger and satiety. Although GLP-1 drugs suppress appetite and can lead to effective weight loss, emerging research suggests that they may also affect brain reward mechanisms, changing the way patients experience foods.

This aspect could prove of paramount significance in the future treatment of obesity. Perhaps GLP-1 receptor agonists do indeed affect and rewire the brain's reward pathways and will thus provide sustained benefits beyond discontinuation. However, more research is required to understand this phenomenon fully.

While for many, Ozempic and Wegovy have revolutionized obesity treatment, these are certainly not a one size fits all. Nonresponders need not lose hope- alternative strategies and medications abound. A consultation with an obesity expert healthcare provider is essential to put together a comprehensive, tailored treatment plan.

The route toward effective weight loss may be challenging, but with the evolution of obesity medicine and a better understanding of individual needs, there is a path forward for everyone.

When you are burning up, even a simple shower can feel confusing. Should you cool your body quickly with cold water or soothe your aches with something warm? Fever is a natural defense mechanism, but the symptoms it brings can make you feel miserable. The right water temperature can help ease discomfort and support your recovery.

Below is a simple breakdown of how fever affects your body, followed by practical shower tips and additional ways to safely bring your temperature down.

How Fever Resets Your Body’s Thermostat

During an infection, your immune system releases chemicals called pyrogens. These signals tell the hypothalamus, which is your internal thermostat, to raise your core temperature. The added heat slows the growth of certain viruses and bacteria and helps immune cells work more efficiently.

This temperature rise is why you feel:

• Chills as your body works to reach the new set point
• Sweating when the fever begins to settle
• Faster heart rate and quicker breathing, which increase fluid loss

Knowing this matters because water that is too cold can trigger intense shivering, which drives your temperature higher. Water that is too hot can widen your blood vessels and increase sweating, which may worsen dehydration.

Cold, Lukewarm, or Hot: Which Shower Helps Most?

Each water temperature works differently with a fever. Understanding these differences helps you choose what your body needs at that moment.

Cold showers cool your skin quickly. They may feel refreshing if you are overheated, but they often trigger shivering. That shivering can raise your core temperature and is especially risky in children.

Lukewarm or tepid showers are the safest choice for most people with fever. This temperature allows gentle heat loss through the skin without causing shivering. It helps you cool down gradually while keeping your body comfortable.

Warm or hot showers can help relieve muscle aches or sinus congestion, especially for adults. However, they can increase sweating and may slightly raise your temperature. Avoid them if you are already overheated or dehydrated.

Simple Shower Tips When You Have a Fever

• Start with lukewarm water to safely reduce temperature and ease discomfort.
• If you feel flushed and sweaty, splash cold water only on pulse points such as the wrists and neck.
• Use warm showers only for congestion relief and follow up with hydration and light clothing.
• If you feel dizzy, sit on a chair outside the shower and let steam fill the bathroom while you take a gentle sponge bath.

Other Safe Ways to Bring Down a Fever

Rest

Your body is already working hard to fight the infection. Light activity can raise your temperature further, so give yourself time to rest and recover.

Stay Hydrated

Fever increases the risk of dehydration, especially if you have vomiting or a poor appetite. Sip water, oral rehydration solutions, or electrolyte drinks. Chilled fluids can also help lower your temperature.

Stay Cool

Keep your room slightly cool and wear loose, breathable clothing. If you have chills, use a light blanket but avoid overheating. You can place a cool cloth on your forehead or under the arms for short intervals.

Medication

Over the counter fever reducers like acetaminophen and ibuprofen can safely lower fever. Always follow dosage guidelines. Avoid aspirin in children because it can lead to Reye's syndrome.

What Not to Do

• Do not take cold showers or ice baths because they trigger shivering and can raise your temperature.
• Avoid alcohol rubs since the alcohol can be absorbed through the skin.
• Do not take extra doses of fever medicine thinking it will work faster.
• Always read medication labels carefully to avoid accidental overdosing.

Turns out, kidney disease is not just a ‘kidney’ problem anymore, it can, in fact, affect other organs, and could even be linked to other chronic conditions, revealed a recent study.

In the US, more than 1 in 7 adults are affected by chronic kidney disease or (CKD). This means that 35.5 million Americans are affected by it, and what makes it worse is that 9 out of 10 people do not even know they have CKD, says the Centers for Disease Control and Prevention (CDC). Amid all these numbers thrown on to, something more concerning lies. A recent Lancet study shows a link between the rise in CKD and other chronic diseases. We are talking about chronic conditions like diabetes, high blood pressure, and obesity.

So, What Does The Study Say?

The researcher saw that 14 percent of adults who are over the age 20 or older, which makes 788 million Americans who had CKD in 2022. The biggest problem is not the disease itself, but the unawareness. Doctors, experts, and researchers from time and again have pointed out how kidney disease is often asymptomatic, this is why it is ignored until it becomes advanced. However, at that point the patients could already need dialysis or even an organ transplant. This gap in early diagnosis and treatment is what has made CKD the ninth leading reason of death, worldwide.

When you kidney functions naturally, it works as the powerhouse of filtration. A pair of healthy kidneys are able to filter and process more than 150 liters of fluid from the blood. These organs are also responsible for filtering out the waste and toxins through your urine. Not just that, but your kidneys also help in red blood cells production that keeps you healthy. When all of that does not happen, it can eventually impact every other organ in your body.

Like they say, everything is connected, and it surely is. For instance, somewhere around 20% of the blood that your heart pumps goes to your kidneys. If someone has diabetes and high blood pressure, it could damage the blood vessels and lead to protein in the urine and a slower filtration rate. It can then lead to other chronic infections, autoimmune disorders, and even genetic variants.

Kidney-Body Relation

If you leave your kidney disease untreated, it could lead to kidney failure. This is when you would be more in need of dialysis or a transplant. Doctors have pointed out that most people do not die of chronic kidney disease, rather it impacts their quality of life, worsening their cardiovascular conditions. It can lead to complications like a heart attack, a stroke, or a heart failure.

How Does This Happen?

People who have kidney diseases are at an increased risk for high blood pressure. Due to hurdles in the process of filtration, plaque build ups and hardens the arteries. This in return increases stress on the heart. In fact, the American Heart Association also defined the link between kidney and heart as 'cardiovascular-kidney metabolic syndrome'. This defines a health disorder that is a condition of the overlap of obesity, chronic kidney disease and cardiovascular diseases.

The bleed out of CKD is not just limited to your heart. The National Institute of Health, US points out that along with heart complications and high blood pressure, CKD could also lead to anemia, mineral and bone disorder, metabolic acidosis, malnutrition, and electrolyte imbalances in the blood.

So, What Is The Best Way To Keep Yourself Safe?

The first way is to note any symptoms and get yourself diagnosed. Look for signs like loss of appetite, unexplained nausea or vomiting. Do you feel tired often? Are you having trouble concentrating? Is there any change in how often you go pee?

Other symptoms like a change in your urine color or texture, or feeling itchy or dry, muscle cramps, unexplained weight loss or skin conditions could also signal towards kidney diseases.

However, not always does CKD show symptoms, experts suggest that to be one step ahead, it is important to undergo regular health checkups, including blood culture. General guidelines usually point towards getting a blood test done every 3 to 6 months. For someone with high blood pressure, diabetes or any other disease, the current guidelines say that those people should get regular blood and urine tests to screen for kidney disease. But what really happens is that though these tests exist, they are still used far too little. Doctors point out that many patients skip them because collecting a urine sample feels inconvenient, and overall awareness about kidney disease remains low. As a result, research shows that only about 35 percent of people with diabetes, and just 4 percent of those with high blood pressure, actually end up getting the recommended urine screening.

A ray of hope is that there are now several effective tools to slow the progression of kidney disease. Along with traditional options like ACE inhibitors, newer classes of medications including certain heart failure drugs and GLP-1 drugs. These medicines have shown to help protect kidney function. Although these newer treatments are not widely used yet, their adoption is steadily increasing.

What is important to remember is to also always consult your GP to ensure all preventative measures are followed carefully.

Consuming enough water each day plays an important role in keeping the body working as it should. It helps digestion and metabolism, supports temperature control, aids waste removal, and keeps organs and tissues in good condition. Still, whenever blood pressure rises, many people look for quick fixes, and one of the most common questions is whether drinking cold water can calm the numbers.

The idea sounds straightforward, but the body reacts to cold in more layered ways. Knowing how cold water influences the heart and blood vessels can help separate fact from assumption. To understand this better, we spoke with Dr Rajeev Chowdry, Director of Internal Medicine at Yatharth Super Speciality Hospital, Sector 20, Faridabad.

Can Cold Water Help With Blood Pressure?

Cold water may bring down blood pressure for a brief period. Drinking chilled water can activate the vagus nerve in some individuals, which slows the heart rate and leads to a short-lived drop in blood pressure. The body also triggers a “diving reflex” when exposed to cold, such as splashing cold water on the face, and this can cause a similar short-term response.

Dr Rajeev explained, “Cold water may lower blood pressure for a small amount of time, but not enough to replace someone’s prescribed treatment for hypertension or to be trusted as a method to manage the condition.” He added that for certain people, cold exposure might have the opposite effect, causing blood vessels to tighten and raising blood pressure instead.

Blood Pressure: Who Is Most At Risk?

According to Dr Rajeev, some groups are more vulnerable to a rise in blood pressure, added strain on the heart, or other problems linked to sudden cold exposure:

• High Blood Pressure (Hypertension) — Cold temperatures narrow blood vessels, which can push blood pressure even higher and raise the risk of stroke or heart attack.
• Older Adults — With age, arteries become less flexible, making it harder for the body to adjust to sudden changes in temperature.
• People With Heart-related Health Issues — Cold exposure can place extra demand on the heart by raising blood pressure, changing heart rate in some cases, and reducing blood flow to the heart as blood vessels tighten. This may trigger chest pain for some individuals.
• Patients With Arrhythmias — Those with irregular heart rhythms may experience worsening symptoms, particularly with sudden contact with cold water.
• Individuals On BP-lowering Medication — Some may feel dizzy, lightheaded, or rarely faint if very cold conditions combine with medication that lowers blood pressure.

In summary, while water alone will not manage high blood pressure, staying well hydrated supports overall health and may contribute to better long-term blood pressure control. Anyone making changes to their routine should check with a healthcare professional, especially those already dealing with medical conditions or concerns about their blood pressure.