Ozempic and Wegovy have received a lot of publicity as revolutionizing treatment options for obesity. Both medications form a class of GLP-1 receptor agonists, which mimic a hormone in the body called glucagon-like peptide-1 and are involved in the regulation of appetite and blood sugar. Indeed, in initial clinical studies, the majority of those on the drugs lost 15% to 22% of body weight, hence much optimism. For most patients, these medications are underwhelming for about 20% of patients due to minimal weight loss or other challenges.

Take a closer look at why the weight loss drugs may not work for everyone, together with what options exist when they don't deliver the expected outcomes.

Why Weight Loss Drugs May Not Work

While GLP-1 receptor agonists have produced phenomenal responses in a majority of patients, it remains a reality that these drugs work differently for different people. Here's why:

1. Genetic and Hormonal Variability

Weight loss medications interact with complex systems in the body that differ from person to person. Genetics, hormones, and individual brain responses to energy regulation play significant roles in determining how a person responds to drugs like Ozempic and Wegovy.

2. Underlying Medical Conditions

Other conditions, such as sleep apnea, may be prevalent and prevent or delay the achievement of weight loss goals. Prescription drugs like antidepressants, steroids, or contraceptives are other medications that can nullify weight loss medication benefits.

3. Unrealistic Expectations

Often, they come to these medications with enormous hopes; expecting the promised rapid and dramatic weight loss. Progress creates disappointment if it has not stalled. In patients who rigidly follow recommended lifestyle modifications, frustration and disappointment are most common.

Why it is Important to Identify Non-responders

For most patients, the effectiveness of GLP-1 receptor agonists is evident within a few weeks of treatment. Weight loss typically begins within a few weeks of initiating therapy and tends to increase with dosage. However, some patients respond very little, if at all, despite strict adherence to their regimen.

For nonresponders, this can feel like a dead end. However, understanding the unique complexities of obesity is essential. This condition stems from brain dysfunction, and the pathways that contribute to weight regulation differ among individuals.

Alternative Treatment Options

When Ozempic or Wegovy doesn’t yield desired results, there are still many paths to explore:

1. Switching to Another GLP-1 Drug

For example, some patients who don't respond well to one GLP-1 receptor agonist might find success with another drug in the same class. Newer medications, such as Zepbound, target other hormone pathways and seem promising even for those not responsive to earlier drugs.

2. Use of Older Medications

While there is much to say about newer drugs, older treatments can still be useful and work for some patients. One can also seek the help of a medical provider specializing in obesity treatments in order to identify the best alternatives.

3. Lifestyle Changes

Diet, exercise, sleep, and stress management continue to be integral components of any weight loss program. New changes may be small but can make an enormous difference in one's health and success.

4. Medical Management of Obesity

It is a complex disorder, and most patients should receive a multidisciplinary treatment. Collaboration with an obesity-aware doctor may mean access to tailored treatment plans, ranging from psychological support all the way to metabolic testing, and many others.

Why Side Effects of Weight Loss Drug Ozempic May Be a Barrier

For others, side effects like nausea, vomiting, or diarrhea hinder them from continuing with these drugs. These symptoms often reduce as the body becomes accustomed, but for some, they might be severe enough to stop treatment altogether. In those instances, alternative drugs or procedures become vital to find.

Long-term effects of Ozempic or Wegovy on the Brain

Another largely unexplored area relates to GLP-1 drugs' long-term effects on the brain's regulation of hunger and satiety. Although GLP-1 drugs suppress appetite and can lead to effective weight loss, emerging research suggests that they may also affect brain reward mechanisms, changing the way patients experience foods.

This aspect could prove of paramount significance in the future treatment of obesity. Perhaps GLP-1 receptor agonists do indeed affect and rewire the brain's reward pathways and will thus provide sustained benefits beyond discontinuation. However, more research is required to understand this phenomenon fully.

While for many, Ozempic and Wegovy have revolutionized obesity treatment, these are certainly not a one size fits all. Nonresponders need not lose hope- alternative strategies and medications abound. A consultation with an obesity expert healthcare provider is essential to put together a comprehensive, tailored treatment plan.

The route toward effective weight loss may be challenging, but with the evolution of obesity medicine and a better understanding of individual needs, there is a path forward for everyone.

As the year draws to a close and 2026 approaches, most women find themselves juggling work deadlines, family responsibilities, and festive plans. In the middle of it all, personal health often slips to the bottom of the list. But doctors say this is exactly the time to pause and take stock of your body, especially your reproductive and hormonal health.

“Annual gynecological screening is one of the simplest ways to prevent silent illnesses, detect early changes, and understand your reproductive health better,” says Dr Tanveer Aujla, Consultant Obstetrician and Gynecologist at Motherhood Hospitals, Noida. Many common conditions show little to no symptoms in the early stages, making routine testing crucial.

Why yearly gynecological check-ups matter

Women often ignore subtle signs like fatigue, irregular periods, unexplained weight changes, or mood swings, assuming they are part of a busy lifestyle. According to Dr Aujla, this delay can be risky. “Conditions like cervical abnormalities, breast lumps, thyroid disorders, vitamin deficiencies, or hormonal imbalance often develop quietly and show symptoms only later,” she explains. A yearly check-up helps catch problems early and allows women to plan their health with confidence, especially if pregnancy is on the horizon.

Pap smear and HPV testing for cervical health

One of the most important screenings is the Pap smear combined with HPV testing. The Pap test looks for abnormal cells on the cervix, while the HPV test detects high-risk viruses responsible for most cervical cancers. “Together, they form a powerful screening tool,” Dr Aujla says. Women between 25 and 65 years should undergo this test every three to five years, or as advised by their doctor.

Breast screening for early detection

Breast health should never be overlooked. Dr Aujla advises yearly mammograms for women above 40, along with clinical breast examinations or ultrasound scans when needed. “These screenings help identify lumps, cysts, or early tissue changes,” she notes. She also stresses the importance of monthly self-examination to check for lumps, pain, or changes like inverted nipples.

Thyroid testing for unexplained symptoms

Thyroid disorders are extremely common in women and often remain undiagnosed. “A simple TSH, T3, and T4 test can explain symptoms like fatigue, mood swings, irregular periods, weight changes, or fertility issues,” says Dr Aujla. Early diagnosis can significantly improve quality of life and prevent long-term complications.

Fertility markers and preconception screening

Tests like AMH offer insight into ovarian reserve and help women plan their reproductive timelines. Dr Aujla points out that this is especially important for women with PCOS, irregular cycles, or delayed family planning. Preconception screening, which includes anemia levels, vitamin D, rubella immunity, blood sugar, and hormonal panels, ensures the body is prepared for a safe pregnancy.

Other essential health screenings

Women over 30 or those with a sedentary lifestyle should also get diabetes and cholesterol tests. Bone health panels checking calcium and vitamin D help prevent future osteoporosis. STI screening is equally important, as infections like chlamydia or gonorrhea can silently damage reproductive health if left untreated.

“Whether you are planning pregnancy or simply want to stay healthy, these tests offer clarity, confidence, and peace of mind,” Dr Aujla concludes. Taking time for these screenings before the year ends is a small step that can protect your health for years to come.

Santa Claus is bad for your health! This is a statement by Dr Nathan Grills, a Public Health Fellow in the Department of Epidemiology and Preventative Medicine, Monash University, Australia. Why is he saying this right ahead of Christmas?

Writing for an article in the British Medical Journal's Christmas issue (BMJ), he says, "Santa only needs to affect health by 0.1% to damage million of lives". He says it would be better if his popularity was rather used to promote healthy living.

Why Is Santa Claus Unhealthy?

Santa Claus's portrayal is where the concerns lie. This was not the first time someone has talked about. In fact, The Conversation in December 2024, talked about this exactly. If you look at Santa, he stands anywhere between 5'6" to 6'6" and weighs between 80Kgs to 136Kgs. He also carries a lot of weight around his belly, which, some may say, keeps him insulated as he sleighs through the snowy lands, but is sure overweight and obese. These portrayal promotes an unhealthy living.

Dr Grils also writes that Santa should rather share Rudolf's snack of carrots and celery sticks than brandy and mince pies, and swap his reindeer for a bike or a walk.

After reviewing existing literature and online sources to understand Santa Claus’s possible impact on public health, the analysis found no peer-reviewed studies directly addressing the issue. What did stand out, however, was the exceptionally high level of awareness of Santa among children. In fact, surveys of American schoolchildren showed that Santa Claus was recognized more widely than almost any other fictional character, second only to Ronald McDonald.

The doctor says that Santa is also used for selling products, which are mostly harmful, and this happens on global scale, which means, people get inspired. "Santa sells, and sometimes he sells harmful products. Like Coca-Cola, Santa has become a major export item to the developing world."

While Santa has been banned from smoking, but his images of enjoying a pipe or cigar are easily found on Christmas cards. The depiction of Santa does form a public perception, argues the doctor.

Dr Grill also notes that Santa may be promoting potential drink-driving, especially when someone follows the tradition to leave him a brandy to wish him well on his travels, while he has billion houses to visit.

Can Santa Spread Diseases?

Dr Grill says that he can spread diseases. If Santa sneezes or coughs around 10 times a day, all the children who sit on his lap may also end up catching the flu along with their Christmas presents.

However, it is important to note that these are views expressed by the doctor and no actual studies have been conducted on the same, Though Dr Grill does indicate for more research before calling for authorities to regulate Santa's activities. For now, Dr Grill proposes a new image for Santa, a healthier one. A slim Santa on a treadmill.

For years, the appendix was brushed off as a useless leftover from human evolution. Many of us grew up believing that it served no real purpose and was better off removed at the first sign of trouble. But science now tells a more interesting story. This small, finger-like pouch attached to the large intestine quietly supports gut health and immunity in ways that were long overlooked.

What exactly is the appendix?

The appendix is a narrow tube connected to the cecum, located in the lower right side of the abdomen. It usually measures between 7 and 10 cm, although its size and position can vary widely from person to person. In some people, it may be just a couple of centimeters long, while in others, it can extend much further. This variation is also why appendicitis pain can sometimes feel confusing or atypical.

Not useless after all

The biggest shift in understanding the appendix came from research into gut bacteria. The appendix appears to act as a safe storage space for beneficial microbes. During bouts of severe diarrhea or intestinal infections, large amounts of gut bacteria are flushed out. The appendix helps reintroduce these good bacteria once the illness passes, helping the digestive system recover faster.

It also plays a role in immunity, especially during early life. The appendix contains lymphoid tissue, which exposes immune cells to substances passing through the gut. This helps the body learn how to respond to harmful invaders while tolerating harmless ones. While humans can survive perfectly well without an appendix, its presence offers subtle support to the immune and digestive systems.

Why appendicitis happens

Despite its benefits, the appendix is still prone to inflammation. Appendicitis is one of the most common abdominal emergencies worldwide. It usually occurs when the appendix gets blocked, often due to hardened stool, infection, or rarely, abnormal growths. Once blocked, bacteria multiply, causing swelling, pain, and infection.

The classic warning sign is pain that starts near the belly button and gradually shifts to the lower right abdomen. This may be accompanied by fever, nausea, vomiting, and loss of appetite. Ignoring these symptoms can be dangerous. If left untreated, the appendix can rupture, leading to serious and potentially life-threatening complications.

Busting Common Myths

There are many myths surrounding the appendix. One of the most common is that fruit seeds or spicy food cause appendicitis. There is no evidence to support this. Another misconception is that appendicitis can settle on its own. While pain may temporarily reduce, the underlying inflammation usually worsens.

Many people also worry that removing the appendix will harm digestion or require lifelong dietary restrictions. In reality, most people return to normal eating habits and daily routines after recovery, with no long-term health issues.

How appendicitis is treated

Surgery remains the most reliable treatment for appendicitis. Today, minimally invasive techniques such as laparoscopic or robotic surgery are widely used. These involve small incisions, less pain, quicker recovery, and shorter hospital stays. In complicated cases, open surgery may still be required.

In selected cases of mild, uncomplicated appendicitis, antibiotics may be used initially. However, studies show that while symptoms may improve, there is a higher chance of recurrence within months. For this reason, surgery continues to be the definitive, long-term solution for most patients.

Recovery after appendix removal is usually smooth. Many patients are able to walk the same day and return home within a day or two. Light meals are recommended initially, and heavy lifting is avoided for a few weeks. Long-term lifestyle changes are rarely needed, and most people forget about the surgery entirely once healed.