Ozempic and Wegovy have received a lot of publicity as revolutionizing treatment options for obesity. Both medications form a class of GLP-1 receptor agonists, which mimic a hormone in the body called glucagon-like peptide-1 and are involved in the regulation of appetite and blood sugar. Indeed, in initial clinical studies, the majority of those on the drugs lost 15% to 22% of body weight, hence much optimism. For most patients, these medications are underwhelming for about 20% of patients due to minimal weight loss or other challenges.

Take a closer look at why the weight loss drugs may not work for everyone, together with what options exist when they don't deliver the expected outcomes.

Why Weight Loss Drugs May Not Work

While GLP-1 receptor agonists have produced phenomenal responses in a majority of patients, it remains a reality that these drugs work differently for different people. Here's why:

1. Genetic and Hormonal Variability

Weight loss medications interact with complex systems in the body that differ from person to person. Genetics, hormones, and individual brain responses to energy regulation play significant roles in determining how a person responds to drugs like Ozempic and Wegovy.

2. Underlying Medical Conditions

Other conditions, such as sleep apnea, may be prevalent and prevent or delay the achievement of weight loss goals. Prescription drugs like antidepressants, steroids, or contraceptives are other medications that can nullify weight loss medication benefits.

3. Unrealistic Expectations

Often, they come to these medications with enormous hopes; expecting the promised rapid and dramatic weight loss. Progress creates disappointment if it has not stalled. In patients who rigidly follow recommended lifestyle modifications, frustration and disappointment are most common.

Why it is Important to Identify Non-responders

For most patients, the effectiveness of GLP-1 receptor agonists is evident within a few weeks of treatment. Weight loss typically begins within a few weeks of initiating therapy and tends to increase with dosage. However, some patients respond very little, if at all, despite strict adherence to their regimen.

For nonresponders, this can feel like a dead end. However, understanding the unique complexities of obesity is essential. This condition stems from brain dysfunction, and the pathways that contribute to weight regulation differ among individuals.

Alternative Treatment Options

When Ozempic or Wegovy doesn’t yield desired results, there are still many paths to explore:

1. Switching to Another GLP-1 Drug

For example, some patients who don't respond well to one GLP-1 receptor agonist might find success with another drug in the same class. Newer medications, such as Zepbound, target other hormone pathways and seem promising even for those not responsive to earlier drugs.

2. Use of Older Medications

While there is much to say about newer drugs, older treatments can still be useful and work for some patients. One can also seek the help of a medical provider specializing in obesity treatments in order to identify the best alternatives.

3. Lifestyle Changes

Diet, exercise, sleep, and stress management continue to be integral components of any weight loss program. New changes may be small but can make an enormous difference in one's health and success.

4. Medical Management of Obesity

It is a complex disorder, and most patients should receive a multidisciplinary treatment. Collaboration with an obesity-aware doctor may mean access to tailored treatment plans, ranging from psychological support all the way to metabolic testing, and many others.

Why Side Effects of Weight Loss Drug Ozempic May Be a Barrier

For others, side effects like nausea, vomiting, or diarrhea hinder them from continuing with these drugs. These symptoms often reduce as the body becomes accustomed, but for some, they might be severe enough to stop treatment altogether. In those instances, alternative drugs or procedures become vital to find.

Long-term effects of Ozempic or Wegovy on the Brain

Another largely unexplored area relates to GLP-1 drugs' long-term effects on the brain's regulation of hunger and satiety. Although GLP-1 drugs suppress appetite and can lead to effective weight loss, emerging research suggests that they may also affect brain reward mechanisms, changing the way patients experience foods.

This aspect could prove of paramount significance in the future treatment of obesity. Perhaps GLP-1 receptor agonists do indeed affect and rewire the brain's reward pathways and will thus provide sustained benefits beyond discontinuation. However, more research is required to understand this phenomenon fully.

While for many, Ozempic and Wegovy have revolutionized obesity treatment, these are certainly not a one size fits all. Nonresponders need not lose hope- alternative strategies and medications abound. A consultation with an obesity expert healthcare provider is essential to put together a comprehensive, tailored treatment plan.

The route toward effective weight loss may be challenging, but with the evolution of obesity medicine and a better understanding of individual needs, there is a path forward for everyone.

Rebecca King Crews, wife of actor Terry Crews, has opened up about her diagnosis with Parkinson's disease, which was previously dismissed as mere anxiety.

Speaking on the TODAY show, she also revealed a newly-approved procedure that has helped manage her symptoms. After three years, she’s able to write.

"I feel good," King Crews said during the segment. "I’m able to write my name and my dates, and I’m able to write with my right hand for the first time in probably three years."

Parkinson's Dismissed As Anxiety

The symptoms came suddenly and progressed quickly. Rebecca revealed that her first set of symptoms appeared around 2012, which began with numbness in her left foot while working out. It then progressed to a limp.

Then her left arm wasn't swinging as much as her right during certain exercises. Another was experiencing tremors while applying lip gloss, putting on makeup, or brushing her teeth. However, her doctor just thought she was having anxiety, the Today report said.

After three years of confusing symptoms, a Parkinson's specialist in 2015 recognized that she had the condition.

US FDA-approved treatment for Parkinson’s

Also read: Japan Approves First-Ever Stem Cell Therapies For Parkinson’s And Heart Failure

In the hope of a miracle, Rebecca was praying on her knees beside her bed when her husband, Terry Crews, informed her of a US Food and Drug Administration (FDA) non-invasive surgical procedure for her symptoms.

Last month, she underwent the new procedure called a bilateral focused ultrasound. The 2025 approved procedure uses sound waves directed into the brain to eradicate the debilitating symptoms.

What Is Parkinson's Disease?

Parkinson's disease is a progressive, neurodegenerative movement disorder caused by the loss of dopamine-producing brain cells, primarily affecting people over 60. Apart from motor loss, the disease also causes cognitive decline, depression, anxiety, and swallowing problems.

The first symptom may be a barely noticeable tremor in just one hand or sometimes a foot or the jaw. Over time, swinging your arms may become difficult, and your speech may become soft or slurred. The disorder also causes stiffness, slowing of movement, and trouble with balance that raises the risk of falls.

Also read: Is Parkinson's Disease Infectious?

What Is A Focused Ultrasound For Parkinson's?

Focused ultrasound is a noninvasive, therapeutic technology with the potential to improve the quality of life and decrease the cost of care for patients with symptoms secondary to Parkinson’s disease.

This novel technology focuses on beams of ultrasonic energy to targets deep in the brain without damaging surrounding normal tissue.

During the procedure, doctors use a device called Exablate Neuro, developed by a company called Insightec, to deliver ultrasound waves to specific areas on both sides of the brain.

They're guided by magnetic resonance imaging (MRI) to target the areas thought to be involved in the movement symptoms in Parkinson's.

The procedure typically produces immediate results and can be a good option for people who can't or don't want to pursue deep-brain stimulation, according to the Michael J. Fox Foundation for Parkinson's Research.

A fall at home might look small, but for women older than 65, a broken hip can be a big and serious health problem. In real medical terms, this condition has a 20 to 30 percent chance of being deadly within the first year.

As people get older, their bones get weaker because of osteoporosis, which makes them more likely to break even from small falls. However, the bigger problem starts once the injury happens.

According to World Health organization (WHO), around 60 per cent of people living with osteoarthritis are women, yet awareness remains limited until symptoms begin to interfere with mobility and daily function.

Loss Of Muscles

Reports show that 70 per cent of women will get arthritis and osteoporosis. Most of them had no idea it was coming. HealthandMe spoke to experts to understand the reasons behind the trend.

Dr Gurdeep Avinash Ratra, Consultant - Orthopedics and Joint Replacement, Manipal Hospitals, Gurugram said that the development of these disorders is gradual and closely tied to physiological changes.

“After the age of 30, there is a steady decline in muscle mass, accompanied by a more rapid reduction in strength and power. With menopause, the significant fall in estrogen levels removes natural protection for bone density and joint health. Over time, this leads to increased bone fragility, reduced muscular support, and stress on joints, thereby elevating the risk of fractures and chronic joint conditions,” Ratra told HealthandMe.

Health Coach Prashant Desai in a post on social media platform X, noted that after the age of 30:

• muscle mass starts declining by 1 per cent every year.
• muscle strength declines three times faster.
• muscle power declines eight times faster.

Treatment

Experts said a hip fracture needs to be treated right away as a serious medical problem that requires care from many different medical specialists, not just a doctor who focuses on bones.

Dr Rajesh Kumar Verma, Director – Orthopedics & Joint Replacement, Max Super Speciality Hospital, Vaishali explained that limited movement can cause blood clots, chest infections, pressure sores, and loss of muscle quickly. Many patients also face a quick drop in their ability to take care of themselves, which can impact both their body and mind.

Also read: Suffering From Mid-back Pain? Doctors Say It May Be Spinal TB

“Delayed treatment further increases risk. Early surgery and prompt recovery treatment help increase the chances of surviving and recovering better,” Verma told HealthandMe.

How to Prevent

• Maintaining a healthy waist circumference as an early indicator of metabolic health.
• Engaging in regular strength training to preserve bone density and muscle mass.
• Ensuring adequate protein intake to support muscle maintenance.
• Incorporating sufficient calcium and Vitamin D into the diet.
• Remaining physically active, with exercise beyond low impact activities alone.
• Get medical help right away if you fall or think you might have a broken bone.
• Have surgery as soon as your doctor suggests it, because it can help you recover better.
• Begin physiotherapy as soon as possible after the surgery to help restore movement and avoid any serious issues.
• Make sure to eat well, paying special attention to getting enough protein, calcium, and vitamin D.
• Check for fall risks at home by looking at things like lighting, floor surfaces, and handrails.

What to avoid

• Do not wait to go to the hospital, even if the hip fracture pain feels okay.
• Avoid staying in bed for long because a hip fracture can lead to infections, pressure sores, and blood clots.
• Do not skip osteoporosis treatment for hip fractures because it is very important to stop broken bones from happening again.
• Avoid skipping follow-ups or rehabilitation sessions for hip fractures after the surgery.

World Health Day serves as a reminder that regular preventive health check-ups stand as mandatory health assessments that all women need to undergo for their long-term health.

Many serious conditions, such as breast cancer, cervical cancer, thyroid disorders, diabetes, and cardiovascular diseases, often remain silent in their early stages, making regular screening the most effective way to detect them early, when treatment is simpler, less invasive, and more successful.

How Preventive Healthcare Can Help Women

Preventive healthcare enables women to take a proactive role in managing their health rather than responding to illness at an advanced stage. Early detection not only improves clinical outcomes but also effectively decreases treatment difficulties, emotional distress and financial costs while providing superior long-term life quality.

This also helps in identifying risk factors early, allowing timely lifestyle modifications that can prevent disease onset altogether.

Despite this, women often deprioritize their own health due to the multiple roles they juggle, balancing careers, caregiving responsibilities, and family needs. There is also a continued hesitation around discussing reproductive and intimate health concerns, along with a lack of awareness, fear of diagnosis, and social stigma, all of which contribute to delays in seeking timely care.

In many cases, women assume that the absence of symptoms indicates good health, which is a common but risky misconception.

Importance Of Routine Screening

Routine screenings such as Pap smears for cervical health, regular breast examinations, mammography where indicated, thyroid function tests, and basic metabolic screenings like blood sugar and cholesterol levels are critical tools in preventive care.

Periodic health check-ups also provide an opportunity for counselling on nutrition, mental well-being, hormonal health, and lifestyle management, areas that are often overlooked but equally important.

World Health Day serves as a reminder to shift from a reactive to a preventive approach. Prioritizing regular health check-ups, normalizing conversations around women’s health, and encouraging a culture of self-care can significantly improve outcomes. Investing in preventive healthcare is one of the most powerful steps women can take towards leading healthier, longer, and more empowered lives.