Ozempic and Wegovy have received a lot of publicity as revolutionizing treatment options for obesity. Both medications form a class of GLP-1 receptor agonists, which mimic a hormone in the body called glucagon-like peptide-1 and are involved in the regulation of appetite and blood sugar. Indeed, in initial clinical studies, the majority of those on the drugs lost 15% to 22% of body weight, hence much optimism. For most patients, these medications are underwhelming for about 20% of patients due to minimal weight loss or other challenges.

Take a closer look at why the weight loss drugs may not work for everyone, together with what options exist when they don't deliver the expected outcomes.

Why Weight Loss Drugs May Not Work

While GLP-1 receptor agonists have produced phenomenal responses in a majority of patients, it remains a reality that these drugs work differently for different people. Here's why:

1. Genetic and Hormonal Variability

Weight loss medications interact with complex systems in the body that differ from person to person. Genetics, hormones, and individual brain responses to energy regulation play significant roles in determining how a person responds to drugs like Ozempic and Wegovy.

2. Underlying Medical Conditions

Other conditions, such as sleep apnea, may be prevalent and prevent or delay the achievement of weight loss goals. Prescription drugs like antidepressants, steroids, or contraceptives are other medications that can nullify weight loss medication benefits.

3. Unrealistic Expectations

Often, they come to these medications with enormous hopes; expecting the promised rapid and dramatic weight loss. Progress creates disappointment if it has not stalled. In patients who rigidly follow recommended lifestyle modifications, frustration and disappointment are most common.

Why it is Important to Identify Non-responders

For most patients, the effectiveness of GLP-1 receptor agonists is evident within a few weeks of treatment. Weight loss typically begins within a few weeks of initiating therapy and tends to increase with dosage. However, some patients respond very little, if at all, despite strict adherence to their regimen.

For nonresponders, this can feel like a dead end. However, understanding the unique complexities of obesity is essential. This condition stems from brain dysfunction, and the pathways that contribute to weight regulation differ among individuals.

Alternative Treatment Options

When Ozempic or Wegovy doesn’t yield desired results, there are still many paths to explore:

1. Switching to Another GLP-1 Drug

For example, some patients who don't respond well to one GLP-1 receptor agonist might find success with another drug in the same class. Newer medications, such as Zepbound, target other hormone pathways and seem promising even for those not responsive to earlier drugs.

2. Use of Older Medications

While there is much to say about newer drugs, older treatments can still be useful and work for some patients. One can also seek the help of a medical provider specializing in obesity treatments in order to identify the best alternatives.

3. Lifestyle Changes

Diet, exercise, sleep, and stress management continue to be integral components of any weight loss program. New changes may be small but can make an enormous difference in one's health and success.

4. Medical Management of Obesity

It is a complex disorder, and most patients should receive a multidisciplinary treatment. Collaboration with an obesity-aware doctor may mean access to tailored treatment plans, ranging from psychological support all the way to metabolic testing, and many others.

Why Side Effects of Weight Loss Drug Ozempic May Be a Barrier

For others, side effects like nausea, vomiting, or diarrhea hinder them from continuing with these drugs. These symptoms often reduce as the body becomes accustomed, but for some, they might be severe enough to stop treatment altogether. In those instances, alternative drugs or procedures become vital to find.

Long-term effects of Ozempic or Wegovy on the Brain

Another largely unexplored area relates to GLP-1 drugs' long-term effects on the brain's regulation of hunger and satiety. Although GLP-1 drugs suppress appetite and can lead to effective weight loss, emerging research suggests that they may also affect brain reward mechanisms, changing the way patients experience foods.

This aspect could prove of paramount significance in the future treatment of obesity. Perhaps GLP-1 receptor agonists do indeed affect and rewire the brain's reward pathways and will thus provide sustained benefits beyond discontinuation. However, more research is required to understand this phenomenon fully.

While for many, Ozempic and Wegovy have revolutionized obesity treatment, these are certainly not a one size fits all. Nonresponders need not lose hope- alternative strategies and medications abound. A consultation with an obesity expert healthcare provider is essential to put together a comprehensive, tailored treatment plan.

The route toward effective weight loss may be challenging, but with the evolution of obesity medicine and a better understanding of individual needs, there is a path forward for everyone.

It is a common theme for people to feel down and sad in winter. However, why do shorter, colder days often bring on feelings of loneliness and gloom? There is a biological reason behind it. As the days get shorter, many people feel a dip in energy or mood, but for millions, this signals Seasonal Affective Disorder (SAD), which is a serious form of depression that shouldn't be ignored. Experts from West Virginia University (WVU) caution that SAD symptoms are very similar to major depressive disorder and must be taken seriously.

What Causes SAD?

SAD is much more than just feeling down when it gets dark. It's a genuine type of depression most often seen during the winter months, especially in places far north where daylight is scarce. The basic problem is simple: less natural light hits your eyes. This drop in sunlight confuses your brain's chemistry.

It messes with two vital brain chemicals: serotonin, which helps stabilize your mood, and melatonin, which controls when you sleep and wake up. This lack of light also throws off your body's internal clock, called the circadian rhythm. When all these elements get disrupted, it triggers feelings of low energy and depression.

What Are The Symptoms Of SAD?

SAD involves a cluster of symptoms that persist and significantly interfere with your daily life. The pattern is usually predictable: symptoms begin in the fall, peak in the winter, and disappear by spring. Symptoms often include:

• Feelings of hopelessness.
• Loss of interest in activities you once enjoyed.
• Significant changes in sleep (often sleeping more, or having disrupted sleep).
• Changes in appetite or increased food cravings.
• Difficulty concentrating and persistent fatigue.

The risk of SAD is higher among younger people, women, and those with a family history of mood disorders.

Can You Treat/Prevent Seasonal Affective Disorder?

Because Seasonal Affective Disorder is highly predictable, experts advise starting preventative treatments early in the fall. Seeing a healthcare provider is essential to determine the best plan and timing for treatment, rather than waiting for severe symptoms to appear later in winter.

Light Therapy

This involves sitting daily before a special light box emitting 10,000 lux of bright white light. Doing this for 30 to 60 minutes each morning is the most common and effective treatment for SAD, as it helps correct the imbalance caused by reduced sunlight exposure.

Cognitive-Behavioral Therapy (CBT)

This form of talk therapy teaches you practical skills to manage negative thinking patterns and behaviors linked to depression. CBT helps individuals reframe their outlook on winter and build effective coping mechanisms to reduce the impact of SAD symptoms.

Medication

In certain situations, a healthcare provider may prescribe antidepressant medication to help regulate mood-affecting brain chemicals like serotonin. This is often considered alongside light therapy or counseling, especially if symptoms of depression are severe or persistent.

Lifestyle Changes

Simple daily habits are powerful tools. Regular exercise boosts mood and energy, while maintaining a consistent sleep schedule keeps your body's internal clock stable. These practical steps offer significant support alongside clinical treatments.

Delhi’s air quality has taken a severe turn for the worse. As of Monday morning, November 3, 2025, the air across the capital officially slipped into the "Very Poor" category. Government data shows that the Air Quality Index (AQI) hit 316 by 9 am, meaning the air is now considered a significant health risk. In fact, one private monitor estimates that breathing the air in Delhi is currently as harmful as smoking 7.8 cigarettes a day.

Researchers and healthcare professionals have explained how pollution not only affects our breathing and lung function, but it affects multiple organs. A 2024 study published in the Scientific Reports journal showed that PM2.5 pollution particles are linked with reduction in life expectancy by 3.7 years.

However, when it comes to organ functions, pollution affects different organs differently. Here’s how.

Why Does Pollution Affect Our Organ Health?

According to the World Health Organization (WHO), air pollution is when the air contains one or more harmful substances like dust, smoke, fumes, or gas for a long time as they hurt our health.

The main way these pollutants affect us is by being breathed in. When you inhale them, they cause damage throughout your body, leading to:

• Inflammation (swelling)
• Stress on your cells
• A weaker immune system
• Changes to your cells that can cause disease (mutagenicity)

What Organs Are Affected By Pollution?

Here is a list of organs that you may not know were affected by pollution.

Brain and Mind

According to UC Davis Environmental Health Sciences Center, these pollutants are small they can travel from your lungs directly into your brain. This toxic exposure is concerning for long-term brain health. It's been linked to a higher risk of developing severe conditions like dementia and Alzheimer’s disease. It may also impact children, potentially affecting intelligence, and increasing the risk of disorders like autism. Research also shows a higher risk of stroke, depression, and anxiety disorders.

Air pollution doesn't just cause disease; it can also cause more immediate, subtle effects on healthy people, which is often called "brain fog" decreased productivity or trouble thinking clearly. Studies across various jobs, from farm workers to office workers—show that short bursts of high outdoor pollution lead to decreased work output.

Heart and Lungs

According to the WHO, the lungs are hit first, leading to immediate problems like asthma and long-term illnesses like lung cancer or emphysema. Once in the bloodstream, the particles tighten your blood vessels (arteries), which forces the heart to work much harder. This sharply increases your risk for life-threatening events like strokes and heart disease.

Skin

The Airly organization explains that your skin is naturally covered in a layer of helpful bacteria, fungi, and viruses—called the microbiome. Air pollutants (like smog) disrupt the size and variety of this helpful microbiome. When this balance is broken, harmful bacteria can grow out of control.

Being the body’s largest organ and completely exposed, shows damage from air pollution through signs like faster aging, more wrinkles, and rashes. Surprisingly, the internal effects go deeper: prolonged exposure to harmful chemicals found in pollution, such as PAHs and ozone, you face an increased risk of developing skin cancer.

Bone

According to a 2024 study published in the Current Osteoporosis Reports, growing evidence shows a link between air pollution and a higher risk of osteoporosis, a disease that makes bones weak. This is a major concern for our aging population, as severe bone fractures greatly increase death risk. While we don't know the exact pollutants or how they cause this, initial research suggests inflammation from dirty air may damage the bones. Identifying this pathway could lead to new treatments.

Kidney

According to the National Kidney Foundation, pollution adds a major toxic burden to your body's internal cleaning crew. A study of 2.5 million U.S. veterans found that breathing polluted air significantly increases the risk of developing kidney disease. The scientists estimated that over the course of the study, air pollution may have caused roughly 45,000 new cases of chronic kidney disease (CKD) and forced over 2,400 patients to start dialysis.

While the exact way air pollution damages the kidneys is still unknown, one main idea is that the tiny pollution particles you inhale travel from your lungs into your bloodstream. The kidneys then try to filter this contaminated blood, and in the process, the tiny particles directly damage the kidney cells.

Reproductive System

According to the Journal of Obstetrics and Gynecology of India pregnant people, pollution exposure increases the likelihood of miscarriages and can harm the developing baby, leading to health issues in unborn and newborn children. It threatens the future health of the population.

When a pregnant woman is exposed to pollutants, it causes an inflammatory reaction that can harm the pregnancy. This toxic exposure is linked to serious problems, including preterm labor, fetal growth restriction, death of the baby before or during birth.

Studies confirm that inhaling tiny pollution particles (PM) and nanoparticles (NP) causes excessive cell damage, leading to mutations in DNA and damage to fats and proteins in the body.

Digestive Health

According to the Northwell Health Organization, new research suggests that the tiny particles found in it contribute to digestive illnesses.

Exposure to pollution also stresses your body. This chronic, pollution-induced stress leads to an overload of inflammation and cell damage (oxidative stress) in the digestive system. This can contribute to common conditions like Irritable Bowel Syndrome (IBS), Inflammatory Bowel Disease (IBD), Gastroesophageal Reflux Disease (GERD).

Breathing in things like fine particles, fumes, and gases can cause inflammation in the digestive tract. Long-term exposure to dirty air is linked to higher risks of GERD and IBD.

Experts and social media users are warning people about the herbal drink ‘Feel Free’ and other products containing kratom, a compound that acts in ways similar to opioids, according to NBC News. The Food and Drug Administration (FDA) has also raised concerns, noting that kratom-based items—derived from a plant native to Southeast Asia—are being sold in gas stations, convenience stores, and vape shops across the United States. This growing availability has sparked questions: What exactly is kratom, and why has it been banned in several U.S. states?

What Is Feel Free?

‘Feel Free’ is a small blue-bottled herbal tonic made by a company called Botanic Tonics. Its key ingredients are Kratom (Mitragyna speciosa) and Kava (Piper methysticum), plants with long histories of traditional use, kratom in Southeast Asia and kava in the South Pacific.

Though often marketed as natural mood boosters, experts caution that their effects on the brain and body are complex and potentially risky. When taken together, kratom and kava can produce sensations of calm euphoria or mental clarity, but they may also trigger side effects and dependency over time.

What Is Kava or Kratom Found in Feel Free Drinks?

Kava- and kratom-based drinks are often promoted as energy or mood-enhancing beverages, yet some users say they can be habit-forming. Kratom works as a stimulant in smaller amounts and acts like an opioid at higher doses, while Kava produces calming, sedative effects, making it popular for easing anxiety or stress.

Although kava is not known to be physically addictive, using it frequently or combining it with alcohol has been associated with liver damage. Many regular consumers of ‘Feel Free’ report needing multiple bottles daily to function normally or to prevent fatigue and irritability. This growing tolerance and dependence echo patterns seen in other substance use problems.

FDA Does Not Approve Kava or Kratom

According to the National Institutes of Health (NIH), the FDA has not approved kava for treating any medical condition. It is available only as a dietary supplement, and in 2002 the agency issued a warning linking kava-containing products to serious liver injury, including liver failure. The FDA recommends speaking with a healthcare provider before using any kava-based supplement.

So, Is 'Feel Free' Safe to Consume?

Botanic Tonics, the company behind Feel Free, told The Independent that the NBC News story contained “false and misleading statements” and that it had received no reports of severe addiction from customers. In 2023, however, the company agreed to pay $8.75 million to settle a class-action lawsuit accusing it of not disclosing kratom-related riskswithout admitting any wrongdoing.

While the product is sold legally in many health food shops and gas stations, that does not mean it’s risk-free. Because neither kratom nor kava are regulated or approved by the FDA, there is little oversight on their safety or how they interact when combined in drinks like Feel Free. Some countries have completely banned kratom, and several U.S. states and cities have restricted its sale. Still, public awareness remains limited, and many consumers—particularly younger people, may not realize they’re consuming ingredients that could lead to dependence.

‘Feel Free’ might look like a typical energy drink, but the blend of kratom and kava carries genuine health risks, especially for people who rely on such products to cope with stress or boost focus. That short burst of energy or calm may come at a far greater cost in the long run.