Ozempic and Wegovy have received a lot of publicity as revolutionizing treatment options for obesity. Both medications form a class of GLP-1 receptor agonists, which mimic a hormone in the body called glucagon-like peptide-1 and are involved in the regulation of appetite and blood sugar. Indeed, in initial clinical studies, the majority of those on the drugs lost 15% to 22% of body weight, hence much optimism. For most patients, these medications are underwhelming for about 20% of patients due to minimal weight loss or other challenges.

Take a closer look at why the weight loss drugs may not work for everyone, together with what options exist when they don't deliver the expected outcomes.

Why Weight Loss Drugs May Not Work

While GLP-1 receptor agonists have produced phenomenal responses in a majority of patients, it remains a reality that these drugs work differently for different people. Here's why:

1. Genetic and Hormonal Variability

Weight loss medications interact with complex systems in the body that differ from person to person. Genetics, hormones, and individual brain responses to energy regulation play significant roles in determining how a person responds to drugs like Ozempic and Wegovy.

2. Underlying Medical Conditions

Other conditions, such as sleep apnea, may be prevalent and prevent or delay the achievement of weight loss goals. Prescription drugs like antidepressants, steroids, or contraceptives are other medications that can nullify weight loss medication benefits.

3. Unrealistic Expectations

Often, they come to these medications with enormous hopes; expecting the promised rapid and dramatic weight loss. Progress creates disappointment if it has not stalled. In patients who rigidly follow recommended lifestyle modifications, frustration and disappointment are most common.

Why it is Important to Identify Non-responders

For most patients, the effectiveness of GLP-1 receptor agonists is evident within a few weeks of treatment. Weight loss typically begins within a few weeks of initiating therapy and tends to increase with dosage. However, some patients respond very little, if at all, despite strict adherence to their regimen.

For nonresponders, this can feel like a dead end. However, understanding the unique complexities of obesity is essential. This condition stems from brain dysfunction, and the pathways that contribute to weight regulation differ among individuals.

Alternative Treatment Options

When Ozempic or Wegovy doesn’t yield desired results, there are still many paths to explore:

1. Switching to Another GLP-1 Drug

For example, some patients who don't respond well to one GLP-1 receptor agonist might find success with another drug in the same class. Newer medications, such as Zepbound, target other hormone pathways and seem promising even for those not responsive to earlier drugs.

2. Use of Older Medications

While there is much to say about newer drugs, older treatments can still be useful and work for some patients. One can also seek the help of a medical provider specializing in obesity treatments in order to identify the best alternatives.

3. Lifestyle Changes

Diet, exercise, sleep, and stress management continue to be integral components of any weight loss program. New changes may be small but can make an enormous difference in one's health and success.

4. Medical Management of Obesity

It is a complex disorder, and most patients should receive a multidisciplinary treatment. Collaboration with an obesity-aware doctor may mean access to tailored treatment plans, ranging from psychological support all the way to metabolic testing, and many others.

Why Side Effects of Weight Loss Drug Ozempic May Be a Barrier

For others, side effects like nausea, vomiting, or diarrhea hinder them from continuing with these drugs. These symptoms often reduce as the body becomes accustomed, but for some, they might be severe enough to stop treatment altogether. In those instances, alternative drugs or procedures become vital to find.

Long-term effects of Ozempic or Wegovy on the Brain

Another largely unexplored area relates to GLP-1 drugs' long-term effects on the brain's regulation of hunger and satiety. Although GLP-1 drugs suppress appetite and can lead to effective weight loss, emerging research suggests that they may also affect brain reward mechanisms, changing the way patients experience foods.

This aspect could prove of paramount significance in the future treatment of obesity. Perhaps GLP-1 receptor agonists do indeed affect and rewire the brain's reward pathways and will thus provide sustained benefits beyond discontinuation. However, more research is required to understand this phenomenon fully.

While for many, Ozempic and Wegovy have revolutionized obesity treatment, these are certainly not a one size fits all. Nonresponders need not lose hope- alternative strategies and medications abound. A consultation with an obesity expert healthcare provider is essential to put together a comprehensive, tailored treatment plan.

The route toward effective weight loss may be challenging, but with the evolution of obesity medicine and a better understanding of individual needs, there is a path forward for everyone.

Abdominal, also known as central obesity, poses a greater health risk than overall obesity, especially in Indians, said Dr. Jitendra Singh, the Union Minister of State (Independent Charge) for Science and Technology.

Speaking at the release of a cardiology textbook titled “Advances in Obesity and Lipid Management in CVD,” by eminent cardiologist Dr. H.K. Chopra, Singh said that even lean and thin-looking individuals often carry significant visceral fat.

Amid a rapidly growing number of chronic conditions, such as diabetes, hypertension, and cardiovascular diseases, the Minister shared that abdominal obesity is the driving factor.

"There is sufficient evidence to show that Central obesity, even in apparently non-obese individuals, predisposes to a wide spectrum of metabolic disorders including diabetes, hypertension, cardiovascular diseases, fatty liver, dyslipidemia, etc.,” Singh, who is also a diabetologist, said.

“In other words, Abdominal or Central obesity is a greater risk factor compared to overall obesity, particularly in the Indian context where even lean and thin-looking individuals often carry significant visceral fat,” he added.

The Minister reiterated the importance of balanced health practices and emphasized the need for following a “sustained lifestyle discipline, adequate sleep, and scientifically guided preventive care”.

What Is Abdominal Obesity?

Abdominal obesity refers to an excessive accumulation of visceral fat around the stomach and internal organs, such as the liver, heart, kidneys, and the mesentery of the intestine.

Unlike subcutaneous fat, which lies beneath the skin, visceral fat is metabolically active and poses greater health risks.

It can increase your risk of heart disease, type 2 diabetes, high blood pressure, stroke, and some types of cancer.

It is because visceral fat produces hormones and other substances that can cause inflammation and insulin resistance, which can lead to these health problems.

A 2024 study from the Washington University School of Medicine in St. Louis, Missouri, showed that a higher level of visceral fat was related to increased amyloid -- accounting for 77 per cent of the effect of high BMI on amyloid accumulation.

Who Is More At Risk Of Abdominal Obesity

The Minister said that while overall obesity is rising among both men and women, the prevalence of abdominal obesity remains disproportionately high and acts as an independent determinant of cardiometabolic risk. The presence of visceral fat around the abdomen, even without generalized obesity, has significant clinical implications and requires early detection and targeted intervention.

A waist circumference of more than 40 inches for men or 35 inches for women may indicate a higher risk of visceral fat accumulation.

While people with a larger waistline or pot belly are at known risk of having visceral fat, thin people too can have fat accumulation in their internal organs.

According to health experts, even people with a healthy weight can have high levels of visceral fat.

This is because visceral fat is not always visible on the outside of the body, and it can accumulate even if a person appears to be thin or in good shape.

Also read: Checking BMI For Body Weight? It Can Wrongly Mark You As Overweight or Obese, Says Study

Strategies for Successful Weight Management

To tackle obesity, one needs a holistic strategy beyond mere weight reduction. Healthy and sustainable weight reduction and improvement of health are more about body composition than mere weight. Major strategies are:

A balanced diet composed of whole foods, lean meats, and good fats in addition to physical exercise encourages sustainable weight reduction.

Resistance training helps in preserving muscle mass along with fat reduction, which improves metabolic well-being.

Prescription weight-loss medication can help manage obesity alongside lifestyle changes.

For people with severe obesity, surgeries such as gastric bypass or sleeve gastrectomy may provide significant long-term advantages.

Prioritize your metabolic health through healthy eating, portion control, and mindful eating for long-term success.

Bipolar disorder is commonly misunderstood as mere mood fluctuations; however, it is a serious and complex mental health condition.

The condition presents extreme mood fluctuations — hyperactivity and impulsiveness — and depressive lows — lethargy and hopelessness.

Bipolar disorder affects over 40 million people worldwide. Yet diagnosis remains challenging, as many people remain undiagnosed or misdiagnosed for long periods. Some are treated for other mental health conditions, such as depression or ADHD, causing delays in effective treatment.

Speaking to HealthandMe, Dr. Kriti Anand, Consultant, Psychiatrist, Paras Health, Panchkula, said: “Early identification of bipolar disorder is essential for the improvement of the condition of patients. It aids in recognizing patterns early on, which helps to stabilize moods and minimize the occurrence of severe and recurring episodes”.

“With the correct identification of the condition and intervention, people can effectively maintain relationships and stay productive,” Dr. Anand added.

Importance Of Early Detection

Recognizing bipolar disorder early is critical for better outcomes. People who do not get a timely diagnosis are likely to experience more frequent and intense mood episodes, which can become harder to manage over time.

Early evaluation allows healthcare professionals to identify patterns and introduce treatments that help stabilize mood and reduce the severity of symptoms.

Notably, the experts stated that treating bipolar disorder simply as depression means that antidepressants are prescribed, which could cause a manic episode to occur.

With early diagnosis, the chances of harmful behaviors are reduced and prevent suicidal tendencies that are often a result of untreated cases of bipolar disorder.

It also enhances the quality of life, enabling patients to maintain healthy relationships, work productively, and attend to their daily responsibilities.

Early symptoms includes

• Extreme irritability, intense happiness, or sudden, uncharacteristic anger
• A sudden, unexplainable rise or decline in energy levels
• Reduced need for sleep without feeling tired or difficulty falling asleep
• Engaging in risky activities
• Racing thoughts or difficulty concentrating

It’s important to conduct a thorough evaluation to ensure an accurate diagnosis. This involves looking at the patient’s medical history and mental health history.

The symptoms are also evaluated using a structured approach. In some cases, a physical examination may also be conducted. As bipolar disorder involves long-term patterns, it’s possible to observe the patient over a long period of time.

Once diagnosed, early intervention can begin. Treatment for bipolar disorder may involve

• drugs to control mood,
• therapy to improve coping abilities,
• lifestyle habits such as sleeping and exercising regularly.

“A thorough and timely evaluation is essential for accurately diagnosing bipolar mood disorder, especially in cases where symptoms overlap with other conditions. Early intervention by mental health experts, in the form of appropriate treatment, therapy, and lifestyle adjustments, can significantly reduce complications," Surg Commodore (Dr.) Sunil Goyal (Retd), Senior Consultant - Psychiatry, Sarvodaya Hospital, Faridabad, told HealthandMe.

"This will help individuals achieve long-term stability of mood along with improved quality of life in all socio-occupational spheres," he added.

Left untreated, bipolar disorder can lead to serious problems that affect every area of your life, including:

• Problems related to drug and alcohol misuse
• Suicide or suicide attempts
• Legal or financial problems
• Trouble getting along with others
• Poor work or school performance

The experts noted that early detection of bipolar disorder is not just about diagnosis; it is about improving lives.

Identifying the condition early helps in reducing the chance of developing serious complications, decreasing the possibility of being misdiagnosed, and also allows for treatment to be delivered in a timely and appropriate manner.

American actress Olivia Munn has opened up about her journey with deadly breast cancer, which came with no typical symptoms.

In her latest interview on CBS News Sunday Morning, the 45-year-old actress recalled being “faced with the possibility of death” in April 2023, when she was diagnosed with Stage 1 breast cancer.

Importantly, the actress had no symptoms, and even tests like a mammogram and ultrasound gave her a clean chit.

"No symptoms. And I had a clear mammogram and a clear ultrasound," Olivia was quoted as saying.

However, the condition was detected after taking the Lifetime Risk Assessment test -- a free online Q&A that gave her a high score estimating the risk of developing breast cancer in a lifetime. The test marked any score above 20 percent as a high risk. Munn's risk score was 37.3 percent.

The online test — Tyrer-Cuzick Risk Model — is publicly accessible and widely recommended by experts, and it calculates a woman’s five-year and lifetime risk of developing breast cancer using a combination of factors like age, family history, genetics, reproductive history, and more.

Post the assessment, she took "an MRI, which led to an ultrasound, which then led to a biopsy," she explained.

The biopsy showed that she had what she described as "an aggressive, fast-moving cancer" in both of her breasts.

Once she learned the diagnosis, she fought back with everything she had. She got a double mastectomy, an ovariectomy, and a partial hysterectomy. Now her risk score is zero.

Instead of recovering quietly, Olivia made it her mission to raise awareness about the condition — posting about her cancer on social media and telling the world about the risk assessment test.

In the years since Munn started sharing her story, the number of women taking the test has increased by 4,000 percent, the report said.

"Knowing that it's really changed so many people's lives. It's been the most amazing thing. There's no way I could have ever predicted it," she said.

In 2025, Olivia’s mother, Kim, was also diagnosed with breast cancer after taking the same risk assessment test.

In an Instagram post, Munn said her mother was diagnosed with Stage 1 HER2-positive breast cancer, a fast-growing but often treatable type of the disease. Her diagnosis came after Munn encouraged her mom and sister to take a free online breast cancer risk assessment.

Also read: Amanda Peet Opens Up About Breast Cancer Battle, Shares Toughest Moment

What Is A Lifetime Risk Assessment Test?

The MagView Tyrer-Cuzick Risk Assessment Calculator is an online tool that helps one calculate their lifetime risk of developing breast cancer.

The tool urges people to reach out to their healthcare professional in case they have any questions about their risk of developing breast cancer and what the best options are for breast cancer screenings or genetic counseling they may have.

Olivia stressed that any woman over 30 should take the test, and if their risk is above 20 percent, they should ask their doctor for a breast MRI.

Also read: Christy Carlson Romano’s Cancer Test Result Shows Why Regular Screening Is Important

Who Should Get Breast Cancer Screening Done?

According to the American Cancer Society, you are considered to be at average risk if you do not have a personal history of breast cancer, a strong family history of it, or a known genetic mutation (like in the BRCA gene) that increases your risk.

This also applies if you have not had chest radiation before the age of 30. These are the breast cancer screening recommendations for women who are at average risk.

Ages 40-44: You have the choice to start getting a mammogram every year.

Ages 45-54: You should get a mammogram every year.

Ages 55 and older: You can switch to getting a mammogram every other year, or you can choose to continue getting one every year.

You should continue to get screened as long as you are in good health and are expected to live at least 10 more years.