Ozempic and Wegovy have received a lot of publicity as revolutionizing treatment options for obesity. Both medications form a class of GLP-1 receptor agonists, which mimic a hormone in the body called glucagon-like peptide-1 and are involved in the regulation of appetite and blood sugar. Indeed, in initial clinical studies, the majority of those on the drugs lost 15% to 22% of body weight, hence much optimism. For most patients, these medications are underwhelming for about 20% of patients due to minimal weight loss or other challenges.

Take a closer look at why the weight loss drugs may not work for everyone, together with what options exist when they don't deliver the expected outcomes.

Why Weight Loss Drugs May Not Work

While GLP-1 receptor agonists have produced phenomenal responses in a majority of patients, it remains a reality that these drugs work differently for different people. Here's why:

1. Genetic and Hormonal Variability

Weight loss medications interact with complex systems in the body that differ from person to person. Genetics, hormones, and individual brain responses to energy regulation play significant roles in determining how a person responds to drugs like Ozempic and Wegovy.

2. Underlying Medical Conditions

Other conditions, such as sleep apnea, may be prevalent and prevent or delay the achievement of weight loss goals. Prescription drugs like antidepressants, steroids, or contraceptives are other medications that can nullify weight loss medication benefits.

3. Unrealistic Expectations

Often, they come to these medications with enormous hopes; expecting the promised rapid and dramatic weight loss. Progress creates disappointment if it has not stalled. In patients who rigidly follow recommended lifestyle modifications, frustration and disappointment are most common.

Why it is Important to Identify Non-responders

For most patients, the effectiveness of GLP-1 receptor agonists is evident within a few weeks of treatment. Weight loss typically begins within a few weeks of initiating therapy and tends to increase with dosage. However, some patients respond very little, if at all, despite strict adherence to their regimen.

For nonresponders, this can feel like a dead end. However, understanding the unique complexities of obesity is essential. This condition stems from brain dysfunction, and the pathways that contribute to weight regulation differ among individuals.

Alternative Treatment Options

When Ozempic or Wegovy doesn’t yield desired results, there are still many paths to explore:

1. Switching to Another GLP-1 Drug

For example, some patients who don't respond well to one GLP-1 receptor agonist might find success with another drug in the same class. Newer medications, such as Zepbound, target other hormone pathways and seem promising even for those not responsive to earlier drugs.

2. Use of Older Medications

While there is much to say about newer drugs, older treatments can still be useful and work for some patients. One can also seek the help of a medical provider specializing in obesity treatments in order to identify the best alternatives.

3. Lifestyle Changes

Diet, exercise, sleep, and stress management continue to be integral components of any weight loss program. New changes may be small but can make an enormous difference in one's health and success.

4. Medical Management of Obesity

It is a complex disorder, and most patients should receive a multidisciplinary treatment. Collaboration with an obesity-aware doctor may mean access to tailored treatment plans, ranging from psychological support all the way to metabolic testing, and many others.

Why Side Effects of Weight Loss Drug Ozempic May Be a Barrier

For others, side effects like nausea, vomiting, or diarrhea hinder them from continuing with these drugs. These symptoms often reduce as the body becomes accustomed, but for some, they might be severe enough to stop treatment altogether. In those instances, alternative drugs or procedures become vital to find.

Long-term effects of Ozempic or Wegovy on the Brain

Another largely unexplored area relates to GLP-1 drugs' long-term effects on the brain's regulation of hunger and satiety. Although GLP-1 drugs suppress appetite and can lead to effective weight loss, emerging research suggests that they may also affect brain reward mechanisms, changing the way patients experience foods.

This aspect could prove of paramount significance in the future treatment of obesity. Perhaps GLP-1 receptor agonists do indeed affect and rewire the brain's reward pathways and will thus provide sustained benefits beyond discontinuation. However, more research is required to understand this phenomenon fully.

While for many, Ozempic and Wegovy have revolutionized obesity treatment, these are certainly not a one size fits all. Nonresponders need not lose hope- alternative strategies and medications abound. A consultation with an obesity expert healthcare provider is essential to put together a comprehensive, tailored treatment plan.

The route toward effective weight loss may be challenging, but with the evolution of obesity medicine and a better understanding of individual needs, there is a path forward for everyone.

Winters can be especially demanding for many women going through menopause or perimenopause. As the colder months arrive, concerns like dry, irritated skin, unexpected hair fall, and increased joint pain become more common. This rise in symptoms is not caused by cold weather alone. It is largely driven by the way seasonal changes interact with the hormonal transitions of menopause. To understand this better, we spoke to Tamanna Singh, Co-founder of Menoveda and a Certified Menopause Coach, who explained why these changes happen.

What Is Menopause?

Menopause is a natural biological phase when a woman’s menstrual cycles stop permanently, signalling the end of her reproductive years. It is officially diagnosed after 12 consecutive months without a period and usually occurs between the ages of 45 and 55, as the ovaries gradually reduce estrogen production.

The phase leading up to this, called perimenopause, involves fluctuating hormones that can trigger symptoms such as hot flashes, mood changes, and sleep disturbances. Postmenopause refers to the stage after menopause, according to the Mayo Clinic.

How Long Does Menopause Last?

Menopause itself is a single milestone rather than a prolonged phase. Once a woman has gone a full year without a menstrual period, she is considered menopausal. After this point, she enters postmenopause, which continues for the rest of her life.

Menopausal Symptoms Worsening During Winters

One of the key changes during menopause is the steady decline in estrogen levels. Estrogen supports skin moisture, collagen formation, healthy hair growth cycles, and joint lubrication. As this hormone decreases, the body becomes more reactive to environmental factors, with winter dryness having a stronger impact.

Menopause In Winters: Why Skin Feels Drier in January

Tamanna Singh explains, “Cold air contains less moisture, and indoor heating further removes the skin’s natural oils. Lower estrogen levels weaken the skin’s protective barrier, increasing water loss. This leads to dryness, flaking, itching, and in some cases, eczema-like conditions. The skin also takes longer to repair itself, which makes winter-related irritation more difficult to manage.”

The Hair Fall Connection

Hair follicles respond closely to hormonal changes. Tamanna notes, “During menopause, shifting estrogen levels and increased androgen activity shorten the hair’s growth phase, leading to more shedding. Winter adds further stress through reduced blood flow to the scalp, dietary imbalances after festive eating, and low Vitamin D levels due to limited sunlight. Combined, these factors make January a common time for noticeable hair thinning and hair fall.”

Why Joint Pain Worsens During Menopause?

Estrogen also plays a role in reducing inflammation and keeping joints well-lubricated. As estrogen levels fall, women may experience stiffness, swelling, and discomfort, which tend to worsen in cold weather. Lower temperatures cause muscles and connective tissues to tighten, reducing flexibility. Staying less active during winter months further adds to joint stiffness and pain.

What Can Help?

Managing these concerns calls for a well-rounded approach. Tamanna recommends:

• Skin: Use rich, oil-based moisturisers regularly and maintain good hydration.
• Hair: Ensure sufficient intake of protein, iron, and biotin, and practice gentle scalp massage to improve blood circulation.
• Joints: Engage in light strength training, yoga, and regular movement to support flexibility. Adequate Vitamin D and calcium intake is especially important during winter.

Winter does not create menopausal symptoms. It simply intensifies what the body is already dealing with. With the right awareness, consistent care, and small seasonal adjustments, women can navigate the colder months with more ease and confidence.

Delhi’s air quality remained in ‘very poor’ category and a thick layer of fog also took over the city. As of 6am, the Air Quality Index or AQI stood at 385. On Monday, the AQI of the city stayed under the ‘severe’ category, and the overall 24-hour average was at 401. The India Meteorological Department (IMD) recorded that the general visibility of Delhi at 6.30am was 350 meters. The IMD also issued a fog alert for December 29 and the morning of December 30. Warning is also extended for neighboring states, including Haryana, Uttar Pradesh, Chandigarh, Punjab, and parts of Northeast, East, and North India.

The IMD on X wrote: “Dense to very dense fog is expected tonight and into the morning of 30th December across several regions including Haryana, Chandigarh & Delhi, Punjab, Uttar Pradesh, and parts of the Northeast, East, and North India. Visibility may be severely reduced, making travel risky. Please drive slowly, use fog lights, and avoid unnecessary journeys.”

Also Read: Is Delhi's Toxic Air Making You Sad And Grumpy? Here's What The Study Says

Pollution Could Harm Your Brain

While we all know the harm pollution could do to your lungs, doctors have also highlighted that pollution could also lead to cognitive ailments. Mental health impacts such as risk of depression, anxiety, ADHD, and neurodevelopmental disorders in children could rise.

Dr Deepika Dahima, a psychologist at AIIMS Delhi said that pollution could put mental health at risk. Prolonged exposure to fine particulate matter like PM10 or PM2.5 could lead to a rise in anxiety, depression, cognitive impairment and chronic stress. Children also show disrupted neural development and learning difficulties, while adults experience irritability, emotional fatigue and impaired decision-making.

Another medical practitioner, Dr Jitender Nagpal, deputy medical superintendent and pediatrician at Sitaram Bhartia Institute of Science, speaking to the news agency PTI said, “Increasingly, a wide spectrum of behavioural and learning issues such as attention difficulties, irritability, and poor academic performance are being noticed in many children.”

Studies too have linked the exposure of particulate matter or PM2.5 with increased ADHD risk. There are research that show a 1.51 fold increase per 5 μg/m³ increase in PM2.5 and others indicating elevated risks when exposure exceeds 16 μg/m³.

Another study published in December 18, in the journal Environmental Research by Oregon Health & Science University, found that everyday exposure to urban air pollution gradually alters brain development in children and young adults. The researchers of the Oregon Health & Science University discovered that exposure to air pollutants at ages 9 to 10 was associated with changes in cortical thickness in the frontal and temporal brain regions that are responsible for executive function, language, mood regulation, and socioemotional processing.

Another study published in Nature Communication notes that after four hours of exposure to particulate matter, it was found that people's ability to perform routine tasks and interpret emotions were highly impacted.

Study's co-author, Dr Thomas Faherty said, "Study provides compelling evidence that even short-term exposure to particulate matter can have immediate negative effects on brain functions essential for daily activities.”

Can Alzheimer's be completely reversed? This is not just about preventing it or ensuring it that the disease slow down, but can it be reversed to achieve full neurological recovery? For the longest, we have known that Alzheimer's is a progressive, degenerative brain disease, which destroys memory, thinking, and eventually the ability to perform simple tasks, but now a team of researchers from Case Western Reserve University, University Hospitals (UH), and Louis Stokes Cleveland VA Medical Center has challenged this belief. They may have found out something that could reverse it, at least so says the animal model.

Instead of targeting plaques or tangles alone, the team looked at something more fundamental: the brain’s energy system.

Their findings, published in Cell Reports Medicine, suggest that restoring the brain’s energy balance may not just slow Alzheimer’s but potentially reverse key features of the disease, at least in animal models.

What Did The Study Find?

The study is led by Kalyani Chaubey from the Pieper Laboratory, and at the center of the study is NAD+, a molecule essential for cellular energy and repair.

NAD+ levels naturally decline with age across the body, including in the brain. When levels drop too low, cells struggle to perform basic functions and eventually fail.

The researchers found that this decline is far more severe in the brains of people with Alzheimer’s. The same sharp drop was also seen in mouse models of the disease, pointing to a shared biological problem.

How the study was conducted

While Alzheimer’s is uniquely human, scientists use specially engineered mice to study it. In this study, two types of mice were used. One model carried human mutations linked to amyloid buildup, while the other carried a mutation affecting the tau protein.

Both amyloid and tau are central to Alzheimer’s pathology. Over time, these mice developed symptoms similar to human Alzheimer’s, including brain inflammation, damage to nerve fibers, breakdown of the blood-brain barrier, reduced formation of new neurons, and severe memory and learning problems.

Restoring energy balance in diseased brains

After confirming that NAD+ levels were dramatically reduced, the researchers tested whether restoring this balance could help. They used a drug called P7C3-A20, developed in the Pieper Laboratory, which supports cells in maintaining healthy NAD+ levels under stress.

Remarkably, the results went beyond prevention. Even when treatment began after significant disease progression, the mice showed reversal of major brain damage. Cognitive function fully recovered in both mouse models, despite their different genetic causes.

Biomarkers and what they signal

The recovery was not just behavioral. Blood levels of phosphorylated tau 217, a biomarker now used clinically in humans to detect Alzheimer’s, returned to normal in treated mice. This provided objective evidence that disease processes had been reversed, not merely masked.

Why this matters for people

The findings suggest a possible paradigm shift. Alzheimer’s damage may not always be permanent. Under certain conditions, the brain appears capable of repairing itself and regaining function.

However, the researchers caution against self-medicating with over-the-counter NAD+ supplements. Some have been shown in animal studies to raise NAD+ to unsafe levels that may increase cancer risk. The drug used in this study works differently, supporting balance rather than excess.