Ozempic and Wegovy have received a lot of publicity as revolutionizing treatment options for obesity. Both medications form a class of GLP-1 receptor agonists, which mimic a hormone in the body called glucagon-like peptide-1 and are involved in the regulation of appetite and blood sugar. Indeed, in initial clinical studies, the majority of those on the drugs lost 15% to 22% of body weight, hence much optimism. For most patients, these medications are underwhelming for about 20% of patients due to minimal weight loss or other challenges.

Take a closer look at why the weight loss drugs may not work for everyone, together with what options exist when they don't deliver the expected outcomes.

Why Weight Loss Drugs May Not Work

While GLP-1 receptor agonists have produced phenomenal responses in a majority of patients, it remains a reality that these drugs work differently for different people. Here's why:

1. Genetic and Hormonal Variability

Weight loss medications interact with complex systems in the body that differ from person to person. Genetics, hormones, and individual brain responses to energy regulation play significant roles in determining how a person responds to drugs like Ozempic and Wegovy.

2. Underlying Medical Conditions

Other conditions, such as sleep apnea, may be prevalent and prevent or delay the achievement of weight loss goals. Prescription drugs like antidepressants, steroids, or contraceptives are other medications that can nullify weight loss medication benefits.

3. Unrealistic Expectations

Often, they come to these medications with enormous hopes; expecting the promised rapid and dramatic weight loss. Progress creates disappointment if it has not stalled. In patients who rigidly follow recommended lifestyle modifications, frustration and disappointment are most common.

Why it is Important to Identify Non-responders

For most patients, the effectiveness of GLP-1 receptor agonists is evident within a few weeks of treatment. Weight loss typically begins within a few weeks of initiating therapy and tends to increase with dosage. However, some patients respond very little, if at all, despite strict adherence to their regimen.

For nonresponders, this can feel like a dead end. However, understanding the unique complexities of obesity is essential. This condition stems from brain dysfunction, and the pathways that contribute to weight regulation differ among individuals.

Alternative Treatment Options

When Ozempic or Wegovy doesn’t yield desired results, there are still many paths to explore:

1. Switching to Another GLP-1 Drug

For example, some patients who don't respond well to one GLP-1 receptor agonist might find success with another drug in the same class. Newer medications, such as Zepbound, target other hormone pathways and seem promising even for those not responsive to earlier drugs.

2. Use of Older Medications

While there is much to say about newer drugs, older treatments can still be useful and work for some patients. One can also seek the help of a medical provider specializing in obesity treatments in order to identify the best alternatives.

3. Lifestyle Changes

Diet, exercise, sleep, and stress management continue to be integral components of any weight loss program. New changes may be small but can make an enormous difference in one's health and success.

4. Medical Management of Obesity

It is a complex disorder, and most patients should receive a multidisciplinary treatment. Collaboration with an obesity-aware doctor may mean access to tailored treatment plans, ranging from psychological support all the way to metabolic testing, and many others.

Why Side Effects of Weight Loss Drug Ozempic May Be a Barrier

For others, side effects like nausea, vomiting, or diarrhea hinder them from continuing with these drugs. These symptoms often reduce as the body becomes accustomed, but for some, they might be severe enough to stop treatment altogether. In those instances, alternative drugs or procedures become vital to find.

Long-term effects of Ozempic or Wegovy on the Brain

Another largely unexplored area relates to GLP-1 drugs' long-term effects on the brain's regulation of hunger and satiety. Although GLP-1 drugs suppress appetite and can lead to effective weight loss, emerging research suggests that they may also affect brain reward mechanisms, changing the way patients experience foods.

This aspect could prove of paramount significance in the future treatment of obesity. Perhaps GLP-1 receptor agonists do indeed affect and rewire the brain's reward pathways and will thus provide sustained benefits beyond discontinuation. However, more research is required to understand this phenomenon fully.

While for many, Ozempic and Wegovy have revolutionized obesity treatment, these are certainly not a one size fits all. Nonresponders need not lose hope- alternative strategies and medications abound. A consultation with an obesity expert healthcare provider is essential to put together a comprehensive, tailored treatment plan.

The route toward effective weight loss may be challenging, but with the evolution of obesity medicine and a better understanding of individual needs, there is a path forward for everyone.

As men step into their 50s and beyond, prostate health becomes an essential part of overall wellbeing. The gland naturally undergoes changes with age, many of which are not cancerous but can still cause discomfort, disrupt daily routines, and affect long-term health. Awareness, early screening, and preventive habits play a crucial role in staying ahead of potential problems.

Why the Prostate Changes With Age

One of the most common age-related concerns is benign prostate hyperplasia (BPH), a non-cancerous enlargement of the prostate. This happens due to hormonal shifts that cause the gland to grow slowly over time.

“Most men assume urinary symptoms are just a normal part of aging, but that mindset often delays treatment,” says Dr. Vineet Malhotra, Director and Founder, VNA Hospital. “BPH itself is not dangerous, but if ignored, it can seriously affect quality of life and even lead to complications.”

A larger prostate can press against the urethra, causing symptoms such as:

• Frequent urination
• Weak or interrupted urine flow
• Difficulty starting to urinate
• A feeling of incomplete bladder emptying
• Waking up multiple times at night to urinate

These symptoms often creep up gradually, making them easy to dismiss until they start interfering with sleep, work, or general comfort.

The Importance of Screening for Prostate Cancer

While BPH is not cancer, men must remain vigilant about prostate cancer, especially because its risk rises with age.

“Prostate cancer in early stages is usually silent,” explains Dr. Malhotra. “That is exactly why screening becomes so important once men cross 50.”

Two common screening tools include:

• PSA (Prostate-Specific Antigen) test
• Digital Rectal Examination (DRE)

These tests help detect abnormalities long before symptoms appear. Early detection not only improves treatment outcomes but also prevents unnecessary anxiety or uncertainty.

Men should also stay alert for red-flag symptoms, including persistent pelvic pain, unexplained weight loss, blood in urine or semen, and sudden urinary changes.

Lifestyle Choices That Support Prostate Health

Beyond medical screening, everyday habits have a strong influence on prostate wellbeing.

Dr. Malhotra emphasizes the role of lifestyle:

“A balanced diet, regular exercise, and maintaining a healthy weight can significantly reduce inflammation and support better prostate function.”

Healthy habits that help include:

• A diet rich in antioxidants (tomatoes, berries, leafy greens)
• Omega-3 sources like fatty fish and walnuts
• Limiting alcohol and caffeine
• Staying well-hydrated
• Avoiding smoking
• Regular physical activity

These choices not only support the prostate but also improve urinary health and hormonal balance.

Since stress can worsen urinary symptoms, incorporating yoga, meditation, or deep-breathing practices also makes a noticeable difference.

Breaking the Silence Around Prostate Health

One of the biggest challenges is the reluctance many men feel when discussing urinary or sexual symptoms.

“Men often suffer quietly because these issues feel too personal,” says Dr. Malhotra. “But silence delays diagnosis and treatment. Open conversations can literally save lives.”

Families, caregivers, and partners can play a supportive role by encouraging early checkups and normalizing discussions around prostate health.

The Bottom Line: Proactive Care Matters

With rising life expectancy and a more active older population, prioritizing prostate health is no longer optional—it’s essential.

Early diagnosis, informed decision-making, and evidence-backed treatments give men the chance to maintain independence, comfort, and quality of life well into their later years.

As Dr. Malhotra puts it, “Prostate health is not just a medical concern—it’s a foundation for staying energetic, confident, and healthy as you age.”

Crossing 40 often brings subtle but noticeable changes in how your body feels and functions. Many people brush off early signs like morning stiffness, reduced flexibility, or frequent bathroom visits, not realizing these are part of natural age-related changes. These shifts primarily affect the bones, joints, and urinary system, areas that quietly define everyday comfort.

According to Dr. Aashish Chaudhry, Managing Director & Head, Orthopedics & Joint Replacement, Aakash Healthcare, these changes are expected but shouldn’t be ignored. “After 40, the body’s regenerative capacity slows down, particularly in bones and joints. Being aware of these changes helps in early prevention and better long-term outcomes,” he says.

Bone Health: Slower Regeneration and Higher Risk of Fractures

Bone density gradually declines with age due to hormonal changes. Women experience a drop in estrogen, and men see reduced testosterone levels—both crucial for supporting bone formation.

“Lower hormone levels weaken the natural bone-building cycle,” explains Dr. Chaudhry. “This increases the risk of fractures and even slows down healing when injuries occur.”

Key concerns include:

• Reduced bone density
• Higher risk of osteoporosis
• Slower fracture recovery

To counter this, weight-bearing exercises and strength training are crucial. A diet rich in calcium, vitamin D, and protein supports bone metabolism and maintains strength.

Joint Health: Wear, Tear, and Early Stiffness

Years of repetitive movements, combined with declining collagen production, make joints more vulnerable. Cartilage becomes less elastic, leading to stiffness, reduced mobility, and the early onset of osteoarthritis.

“Many people notice joint pain but assume it's just fatigue,” says Dr. Chaudhry. “In reality, early joint wear can be detected and managed much earlier with the right interventions.”

What contributes to joint discomfort after 40?

• Natural wear and tear
• Reduced cartilage elasticity
• Slower lubrication of joint spaces
• Early degenerative changes

Flexibility-focused exercises like yoga or stretching, along with anti-inflammatory foods such as leafy greens, berries, nuts, and omega-3 sources, can ease stiffness and protect long-term mobility.

Urinary Changes: More Common Than You Think

While both men and women experience changes in urinary patterns, men often notice symptoms more prominently due to prostate enlargement. A bigger prostate narrows the urinary passage, causing:

• Frequent urination
• Weak urinary stream
• Urgency or incomplete emptying
• Night-time urination

Women, on the other hand, may struggle with pelvic floor weakness, leading to leakage or urgency.

Dr. Chaudhry notes, “These symptoms are common after 40, but they shouldn’t be normalized. Early evaluation can prevent chronic discomfort.”

Hydration remains essential. Cutting back on caffeine, alcohol, and salty foods can also lighten urinary symptoms and prevent kidney irritation.

Lifestyle Adaptations That Make a Real Difference

Shifting from reactive to preventive care is key after 40. The goal isn’t to stop ageing—it's to age comfortably and confidently.

What helps:

• Strength and mobility exercises
• Pelvic floor training
• Maintaining a healthy weight
• Regular health screenings (bone density, kidney tests, prostate evaluation)
• Stress management through yoga, meditation, or deep breathing
• Consistent sleep routines to support tissue repair

“Think of this stage as preparing your body for the next decades,” says Dr. Chaudhry. “With the right lifestyle adjustments, most people can maintain excellent mobility and function well into older age.”

After the Thanksgiving, on Friday, the Food and Drug Administration (FDA)'s top vaccine regulator, Vinay Prasad made a clam that shocked the public-health established. "For the first time, the US FDA will acknowledge that COVID-19 vaccines have killed American children," he wrote in a leaked email to his staff, as reported by The Atlantic and The Washington Post.

The agency has identified that at least 10 children died after getting COVID shots.

The email has been perceived by physicians as a "threat". A response from 12 former FDA commissioners, published in The New England Journal of Medicine on Wednesday, called Prasad's memo "a threat to evidence-based vaccine policy and public health security". All of the potential vaccine related deaths reported to government were already reviewed by the agency's staff, and had reached "different conclusions", wrote the former commissioners.

Elsewhere, doctors and scientists have declared that there are no evidence that links COVID-19 vaccines to deaths in children. The commissioners have claimed that in an attempt to deliberately bring evidence, Prasad and his colleagues had engaged in an "evidence-manufacturing mission", a "dumpster dive" for shoddy data, or worse, a campaign of lying.

Prasad is one of several public health officials who, under Robert F. Kennedy Jr.’s leadership, have been steadily chipping away at public trust in vaccines. So far, he has not provided evidence to back his claims, and his estimate of vaccine-related deaths may be exaggerated. The memo’s intense language and focus on political complaints also cast doubt on his assertions.

However, something that cannot be ignored is that fact that his memo may have provoked people to deny even the possibility of COVID-vaccine-related deaths. The Atlantic notes that "the idea that mRNA-based shots have, tragically, killed a very small number of children is not far-fetched." The article written by Benjamin Mazer, a physician who specializes in pathology and laboratory, notes that the this does not imply a "catastrophic threat to public health" as tens of millions of doses of the same vaccines have saved young people.

Understanding the Debate Of Vaccine-Linked Deaths

Public-health experts agree that COVID vaccines, like all medical treatments, can cause side effects. Myocarditis, a rare heart inflammation seen mostly in adolescent boys and young men after mRNA shots, remains the most discussed risk. Although usually mild and far less severe than virus-induced myocarditis, a few deaths have been documented worldwide, including isolated cases in the U.S., South Korea, and two American teenagers described in a peer-reviewed report.

These findings fuel ongoing debate about whether extremely rare vaccine-related deaths are being overlooked. Some scientists, including Paul Offit and Michael Osterholm, say the evidence does not prove the vaccines caused these deaths, noting that population-level studies show no rise in mortality after vaccination. Others argue that well-investigated autopsy-confirmed cases should be taken seriously rather than dismissed outright.

Experts such as Krutika Kuppalli, as cited by Mazer, emphasize that even if deaths occur, they are so uncommon they do not appear statistically, while the benefits, significantly reduced COVID mortality, are unmistakable. However, individual cases still raise questions on health authorities and the stricter standards of proofs they have applied when vaccines were involved to create a room for skepticism.

The concern is that rare side effects of vaccines could go undiscovered and not that vaccinations are inherently harmful.