Ozempic and Wegovy have received a lot of publicity as revolutionizing treatment options for obesity. Both medications form a class of GLP-1 receptor agonists, which mimic a hormone in the body called glucagon-like peptide-1 and are involved in the regulation of appetite and blood sugar. Indeed, in initial clinical studies, the majority of those on the drugs lost 15% to 22% of body weight, hence much optimism. For most patients, these medications are underwhelming for about 20% of patients due to minimal weight loss or other challenges.

Take a closer look at why the weight loss drugs may not work for everyone, together with what options exist when they don't deliver the expected outcomes.

Why Weight Loss Drugs May Not Work

While GLP-1 receptor agonists have produced phenomenal responses in a majority of patients, it remains a reality that these drugs work differently for different people. Here's why:

1. Genetic and Hormonal Variability

Weight loss medications interact with complex systems in the body that differ from person to person. Genetics, hormones, and individual brain responses to energy regulation play significant roles in determining how a person responds to drugs like Ozempic and Wegovy.

2. Underlying Medical Conditions

Other conditions, such as sleep apnea, may be prevalent and prevent or delay the achievement of weight loss goals. Prescription drugs like antidepressants, steroids, or contraceptives are other medications that can nullify weight loss medication benefits.

3. Unrealistic Expectations

Often, they come to these medications with enormous hopes; expecting the promised rapid and dramatic weight loss. Progress creates disappointment if it has not stalled. In patients who rigidly follow recommended lifestyle modifications, frustration and disappointment are most common.

Why it is Important to Identify Non-responders

For most patients, the effectiveness of GLP-1 receptor agonists is evident within a few weeks of treatment. Weight loss typically begins within a few weeks of initiating therapy and tends to increase with dosage. However, some patients respond very little, if at all, despite strict adherence to their regimen.

For nonresponders, this can feel like a dead end. However, understanding the unique complexities of obesity is essential. This condition stems from brain dysfunction, and the pathways that contribute to weight regulation differ among individuals.

Alternative Treatment Options

When Ozempic or Wegovy doesn’t yield desired results, there are still many paths to explore:

1. Switching to Another GLP-1 Drug

For example, some patients who don't respond well to one GLP-1 receptor agonist might find success with another drug in the same class. Newer medications, such as Zepbound, target other hormone pathways and seem promising even for those not responsive to earlier drugs.

2. Use of Older Medications

While there is much to say about newer drugs, older treatments can still be useful and work for some patients. One can also seek the help of a medical provider specializing in obesity treatments in order to identify the best alternatives.

3. Lifestyle Changes

Diet, exercise, sleep, and stress management continue to be integral components of any weight loss program. New changes may be small but can make an enormous difference in one's health and success.

4. Medical Management of Obesity

It is a complex disorder, and most patients should receive a multidisciplinary treatment. Collaboration with an obesity-aware doctor may mean access to tailored treatment plans, ranging from psychological support all the way to metabolic testing, and many others.

Why Side Effects of Weight Loss Drug Ozempic May Be a Barrier

For others, side effects like nausea, vomiting, or diarrhea hinder them from continuing with these drugs. These symptoms often reduce as the body becomes accustomed, but for some, they might be severe enough to stop treatment altogether. In those instances, alternative drugs or procedures become vital to find.

Long-term effects of Ozempic or Wegovy on the Brain

Another largely unexplored area relates to GLP-1 drugs' long-term effects on the brain's regulation of hunger and satiety. Although GLP-1 drugs suppress appetite and can lead to effective weight loss, emerging research suggests that they may also affect brain reward mechanisms, changing the way patients experience foods.

This aspect could prove of paramount significance in the future treatment of obesity. Perhaps GLP-1 receptor agonists do indeed affect and rewire the brain's reward pathways and will thus provide sustained benefits beyond discontinuation. However, more research is required to understand this phenomenon fully.

While for many, Ozempic and Wegovy have revolutionized obesity treatment, these are certainly not a one size fits all. Nonresponders need not lose hope- alternative strategies and medications abound. A consultation with an obesity expert healthcare provider is essential to put together a comprehensive, tailored treatment plan.

The route toward effective weight loss may be challenging, but with the evolution of obesity medicine and a better understanding of individual needs, there is a path forward for everyone.

New health data has prompted the NHS to once again encourage certain groups to get their flu vaccination. Recent figures from NHS England show that cases of winter viruses are climbing again.

For example, as per Mirror, hospital admissions due to flu have risen by 9% over the past two weeks, after the previous fortnight had suggested a decline in cases. At the same time, daily numbers of patients admitted with norovirus and Covid have increased compared with the previous week.

Despite these rising cases, the NHS confirmed that it has administered over 18.6 million flu vaccines this winter, an increase of more than half a million compared with the same period last year. With the surge in winter viruses putting extra strain on hospitals and ambulance services, the NHS emphasised that thousands of flu vaccination appointments are still available.

NHS Issues New Flu Jab Alert

Posting on X, the NHS said: "Flu can be serious, especially for older people and those at higher risk. Millions have already been vaccinated this season, and there are still thousands of appointments available.

"If you're eligible, it’s not too late to get yours." Many people, particularly those in vulnerable groups, may qualify for a free flu vaccine.

Who Is Eligible For The Free Flu Jab?

According to NHS guidance, there are six main categories of people eligible for a free flu jab. You might qualify if you need additional protection or if someone in your household does.

This includes people who:

• Are pregnant
• Have certain long-term health conditions
• Live in a care home
• Are aged 65 or over, or will turn 65 by March 31, 2026
• Are the main carer for an older or disabled person, or receive a carer's allowance
• Live with someone with a weakened immune system (for example, someone undergoing chemotherapy)

NHS national medical director Professor Meghana Pandit said: "It’s clear that the worst is far from over for the NHS this winter. Hospitals have seen another rise in admissions from flu and other respiratory viruses last week. The cold weather is also contributing to an increase in vulnerable patients visiting A&E with respiratory issues and more injuries from slips and falls due to icy conditions, so it remains an extremely busy period."

How To Get The Flu Vaccine For Free?

If you qualify for a free flu jab, there are several ways to access it. As per Mirror, you can call your GP surgery directly to book an appointment, or arrange one at a pharmacy either online or through the NHS app, as long as you are 18 or older.

Some pharmacies also offer the NHS vaccine at no cost and accept walk-ins without prior booking. This service isn’t available at every pharmacy, but you can locate the nearest pharmacy offering the complimentary vaccine here.

Itchy skin is something most of us deal with occasionally, and in many cases, it is harmless. Everyday triggers such as rough clothing, insect bites, or dry winter air can all leave the skin irritated. Itching is also commonly linked to skin conditions like eczema or psoriasis.

That said, an oncologist has pointed out that persistent itching can, in some cases, be linked to certain cancers. In a TikTok video, Dr Amit Garg, a cancer specialist based in California, explained that itching can appear as a symptom in four specific types of cancer. While itching alone is not usually a cause for concern, it may become more meaningful when it occurs alongside other symptoms that should be checked by a GP.

1. Hodgkin Lymphoma

Hodgkin lymphoma is a relatively rare cancer that affects lymphocytes, the white blood cells that help the body fight infection. Dr Garg explained that this cancer can cause “severe, widespread itching,” which often becomes worse at night. The NHS also lists itchy skin as a possible symptom, along with:

• A painless lump or swelling, usually in the neck, armpit, or groin, which is the most common sign
• Pain in the glands of the neck, armpit, or groin after drinking alcohol
• A high temperature
• Night sweats
• Shortness of breath
• Sudden, unexplained weight loss

The NHS advises seeing a GP if you notice any of these symptoms. Although they are common and do not always point to Hodgkin lymphoma, it is important to rule it out. Early diagnosis improves the chances of successful treatment, so symptoms should not be ignored.

2. Polycythemia Vera

Polycythemia vera is a rare, slow-developing blood cancer. According to the NHS, it is most often caused by a change in the JAK2 gene, which leads the bone marrow to produce too many red blood cells. An increased concentration of red blood cells is known as erythrocytosis, although having this condition does not automatically mean cancer.

One symptom of erythrocytosis can be itchy skin, particularly after bathing or showering. You should speak to a GP if symptoms persist. Other signs may include:

• Headaches
• Blurred vision
• Reddened skin, especially on the face, hands, and feet
• Tiredness
• High blood pressure
• Dizziness
• Discomfort in the abdomen
• Confusion
• Bleeding issues such as nosebleeds or bruising
• Gout, which can cause joint pain, stiffness, and swelling

3. Gallbladder And Pancreatic Cancer

Gallbladder cancer and pancreatic cancer often share similar symptoms. These can include a reduced appetite, unintentional weight loss, fever, nausea, and changes in bowel habits such as diarrhoea or constipation.

Dr Garg explained that both cancers can cause “intense itching,” which happens when bile salts build up under the skin. The NHS also lists itching as a symptom for both conditions, noting it may occur alongside darker urine, paler stools, and jaundice, which can cause yellowing of the skin or the whites of the eyes.

One key difference between the two cancers is the type of pain experienced. Gallbladder cancer may cause a dull ache on the right side of the abdomen, while pancreatic cancer more commonly causes pain in the upper abdomen and back, which can worsen after eating or when lying down.

In both cases, you should see a GP if symptoms last longer than two weeks or if you have lost weight without trying. You should call 111 if vomiting lasts more than two days, diarrhoea continues for more than seven days, or if your skin turns yellow.

4. Cutaneous T-cell Lymphoma

Cutaneous T-cell lymphoma is a form of skin lymphoma and a rare type of non-Hodgkin lymphoma. It begins in the T cells of the skin and often appears as flat, red patches that may be itchy.

In its early stages, these patches can resemble common skin conditions such as eczema or psoriasis. Seeing a GP is important if symptoms develop, as they can assess whether it is a common skin issue or something more serious.

Cancer Research UK states that around 150 people in the UK are diagnosed with cutaneous T-cell lymphoma each year, making it a rare cancer. As with many cancers, early diagnosis can play a key role in improving treatment outcomes.

A GP has advised women to make three simple health checks part of their monthly routine, saying the start of the month can act as a helpful prompt to stay consistent. The advice comes from Dr Carys Sonnenberg, an NHS women’s health GP and the founder of the Rowena Health Menopause Clinic. Speaking to her large audience on TikTok through her account @Rowenahealth_menopause, the doctor, author, and public speaker suggested setting aside the first day of every month for these routine checks.

Even if the date has already passed this month, she noted it can still serve as a timely nudge for those who have not yet done them, and a useful habit to follow going forward.

Three Health Checks Doctor Recommends

In her video, Dr Carys explained to viewers: “It’s the first of the month, so it’s a really good day to do your chest check, to do your vulva check, and also to examine any moles that you have on your body, not forgetting your head.” She added that becoming familiar with your own body is key. “When you’re checking yourself, it really helps to understand what’s normal for you. I’m Dr Carys Sonnenberg.

“I’m a GP and a menopause specialist. There is some excellent guidance online that shows you how to check your chest properly, what changes to be mindful of, and which symptoms should be discussed with your GP.

How To Do Health Checks Properly

“For the rest of your body, you’ll need a mirror. You might also want someone to help check areas you cannot easily see, such as your back, in case there are skin moles that look different or have changed. Don’t forget to part your hair and look at your scalp as well, in case there’s anything unusual that needs attention. I hope that’s helpful.”

Breast Changes To Watch For

Health experts stress the importance of staying alert to changes in your breasts or chest that could signal a problem. Making monthly checks a habit is a simple way to stay aware, while also remembering that some changes can occur naturally, such as during different phases of your menstrual cycle.

Possible signs of breast cancer can include:

• Skin changes like puckering or dimpling
• An unusual lump or swelling in the armpit or near the collarbone
• New lumps or areas of thickened tissue
• Fluid leaking from the nipple
• Crusting or a rash on or around the nipple
• A nipple that turns inward or changes direction
• A sudden change in breast size or shape
• Ongoing, unexplained pain in the breast, chest, or armpit

Secondary symptoms may include trouble sleeping, feeling generally unwell or sick, a loss of appetite, unexpected weight loss, and ongoing tiredness or low energy. While these signs do not always point to breast cancer, doctors advise contacting your GP if you notice anything unusual. Always speak to your GP if you have concerns about your health.