Ozempic and Wegovy have received a lot of publicity as revolutionizing treatment options for obesity. Both medications form a class of GLP-1 receptor agonists, which mimic a hormone in the body called glucagon-like peptide-1 and are involved in the regulation of appetite and blood sugar. Indeed, in initial clinical studies, the majority of those on the drugs lost 15% to 22% of body weight, hence much optimism. For most patients, these medications are underwhelming for about 20% of patients due to minimal weight loss or other challenges.

Take a closer look at why the weight loss drugs may not work for everyone, together with what options exist when they don't deliver the expected outcomes.

Why Weight Loss Drugs May Not Work

While GLP-1 receptor agonists have produced phenomenal responses in a majority of patients, it remains a reality that these drugs work differently for different people. Here's why:

1. Genetic and Hormonal Variability

Weight loss medications interact with complex systems in the body that differ from person to person. Genetics, hormones, and individual brain responses to energy regulation play significant roles in determining how a person responds to drugs like Ozempic and Wegovy.

2. Underlying Medical Conditions

Other conditions, such as sleep apnea, may be prevalent and prevent or delay the achievement of weight loss goals. Prescription drugs like antidepressants, steroids, or contraceptives are other medications that can nullify weight loss medication benefits.

3. Unrealistic Expectations

Often, they come to these medications with enormous hopes; expecting the promised rapid and dramatic weight loss. Progress creates disappointment if it has not stalled. In patients who rigidly follow recommended lifestyle modifications, frustration and disappointment are most common.

Why it is Important to Identify Non-responders

For most patients, the effectiveness of GLP-1 receptor agonists is evident within a few weeks of treatment. Weight loss typically begins within a few weeks of initiating therapy and tends to increase with dosage. However, some patients respond very little, if at all, despite strict adherence to their regimen.

For nonresponders, this can feel like a dead end. However, understanding the unique complexities of obesity is essential. This condition stems from brain dysfunction, and the pathways that contribute to weight regulation differ among individuals.

Alternative Treatment Options

When Ozempic or Wegovy doesn’t yield desired results, there are still many paths to explore:

1. Switching to Another GLP-1 Drug

For example, some patients who don't respond well to one GLP-1 receptor agonist might find success with another drug in the same class. Newer medications, such as Zepbound, target other hormone pathways and seem promising even for those not responsive to earlier drugs.

2. Use of Older Medications

While there is much to say about newer drugs, older treatments can still be useful and work for some patients. One can also seek the help of a medical provider specializing in obesity treatments in order to identify the best alternatives.

3. Lifestyle Changes

Diet, exercise, sleep, and stress management continue to be integral components of any weight loss program. New changes may be small but can make an enormous difference in one's health and success.

4. Medical Management of Obesity

It is a complex disorder, and most patients should receive a multidisciplinary treatment. Collaboration with an obesity-aware doctor may mean access to tailored treatment plans, ranging from psychological support all the way to metabolic testing, and many others.

Why Side Effects of Weight Loss Drug Ozempic May Be a Barrier

For others, side effects like nausea, vomiting, or diarrhea hinder them from continuing with these drugs. These symptoms often reduce as the body becomes accustomed, but for some, they might be severe enough to stop treatment altogether. In those instances, alternative drugs or procedures become vital to find.

Long-term effects of Ozempic or Wegovy on the Brain

Another largely unexplored area relates to GLP-1 drugs' long-term effects on the brain's regulation of hunger and satiety. Although GLP-1 drugs suppress appetite and can lead to effective weight loss, emerging research suggests that they may also affect brain reward mechanisms, changing the way patients experience foods.

This aspect could prove of paramount significance in the future treatment of obesity. Perhaps GLP-1 receptor agonists do indeed affect and rewire the brain's reward pathways and will thus provide sustained benefits beyond discontinuation. However, more research is required to understand this phenomenon fully.

While for many, Ozempic and Wegovy have revolutionized obesity treatment, these are certainly not a one size fits all. Nonresponders need not lose hope- alternative strategies and medications abound. A consultation with an obesity expert healthcare provider is essential to put together a comprehensive, tailored treatment plan.

The route toward effective weight loss may be challenging, but with the evolution of obesity medicine and a better understanding of individual needs, there is a path forward for everyone.

The NHS has issued an alert for anyone taking a widely used heart medication. People are being advised to watch for serious warning signs, including yellowing of the skin or “nosebleeds lasting more than 10 minutes.”

What Is Propranolol?

Propranolol is a beta blocker that slows the heart rate and relaxes blood vessels, helping lower blood pressure and reduce the heart’s oxygen demand. It is also prescribed to ease symptoms of anxiety, such as trembling or excessive sweating, and can help prevent migraines. The medication is prescription-only but is commonly prescribed throughout the UK.

According to the Mirror, the British Heart Foundation reports that more than 50 million beta blocker prescriptions are issued in the UK each year, including for propranolol. Patients usually take it once a day, in either a standard or slow-release form.

While propranolol is generally safe, it does carry possible side effects. The NHS advises contacting 111 immediately if serious symptoms affecting the blood or kidneys appear.

The NHS notes: “Like all medicines, propranolol can cause side effects in some people, but many experience none or only minor effects. Side effects often ease as your body adjusts to the medication.”

Propranolol Side Effects

Common side effects include headaches, fatigue, weakness, cold fingers or toes, nausea, and stomach discomfort. While most people over 12 can safely take propranolol, the NHS recommends consulting a doctor first if you have a history of low blood pressure, heart failure, depression, or diabetes.

More serious reactions can occur, including yellowing of the eyes or skin, pale stools, or dark urine. The NHS also warns of nosebleeds lasting longer than 10 minutes, unexplained bruising, or increased tendency to bruise easily.

Anyone experiencing these warning signs should contact a doctor or call 111 immediately. The NHS also cautions against stopping propranolol abruptly without medical guidance, as this could trigger severe heart problems, including chest pain or even a heart attack.

Who Should Be Extra Cautious With Propranolol

While propranolol is widely prescribed and generally safe for most adults, certain people need to monitor themselves more closely or consult their doctor before use. Those with low blood pressure, heart failure, slow heart rates, diabetes, respiratory conditions like asthma, or a history of depression may face higher risks of side effects. Pregnant or breastfeeding women should also speak to a healthcare professional before taking the medication.

The NHS emphasizes that even minor symptoms—like unusual fatigue, dizziness, or cold hands and feet—should not be ignored, especially if they worsen over time. Monitoring for these effects early can prevent more serious complications.

Disclaimer: This article is for informational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you experience any side effects or unusual symptoms while taking propranolol or any other prescription medicine, seek medical attention immediately.

A California man died last weekend after eating so-called death cap mushrooms, marking the third fatality linked to the toxic fungi in the state since November.

Health officials say California is seeing an unusually high number of mushroom poisonings this season. Between November 18 and January 4, at least 35 cases were reported statewide. In a typical year, the number is usually fewer than five.

“This year’s figures are far beyond what we normally see,” said Sheri Cardo, a communications specialist with the California Department of Public Health.

California Resident Dies After Eating Death Cap Mushrooms

At least three people have now lost their lives in California due to death cap mushroom poisoning since November. Media reports indicate a sharp rise in cases tied to foraged wild mushrooms, with more than 35 poisonings recorded over the past three months.

“The numbers we’re dealing with this year are comparatively off the charts,” Cardo told NBC News.

The most recent death occurred in Sonoma County and was the first fatal wild mushroom poisoning reported there this season, according to county health officials.

Dr. Michael Stacey, interim health officer for Sonoma County, urged residents to avoid eating wild mushrooms unless they are purchased from reliable grocery stores or licensed sellers. He warned that death cap mushrooms can look strikingly similar to safe, edible varieties.

What Is Death Cap Mushroom Poisoning?

Death cap mushrooms, scientifically known as Amanita phalloides, are among the most poisonous mushrooms in the world. They commonly grow beneath oak trees and can be found in parks, gardens, and wooded areas.

Experts say these mushrooms are often mistaken for edible types because of their appearance. Typical features include:

• A smooth cap that may appear whitish, pale yellow, light brown, or green
• White gills underneath the cap
• A white spore print
• A cup-like structure called a volva at the base of the stem
• A ring, known as an annulus, around the stem

Death Cap Mushroom Symptoms

Symptoms usually begin between six and 24 hours after ingestion. Early signs often include stomach pain, nausea, vomiting, and diarrhoea.

In many cases, symptoms ease or disappear after one or two days, which can create a false sense of recovery. By that point, however, the toxins may have already caused severe damage to the liver.

According to experts, the poison responsible, known as amatoxin, can seriously harm the liver, kidneys, and digestive system. Without prompt treatment, the damage can be fatal.

U.S. Poison Centers receive an average of about 52 calls each year related to amatoxin exposure, said Hallen-Adams, though not every case is officially reported.

Is the Risk Easing?

The danger may now be starting to decline in parts of California. Mike McCurdy, president of the Mycological Society of San Francisco, said he has noticed far fewer death cap mushrooms during recent foraging trips.

Earlier this winter, McCurdy said he spotted hundreds of death caps during a two- to three-hour walk in Sonoma County. On a recent outing near Lafayette, California, he found just one. “I think we’re getting close to the end,” he said.

Nearly four years ago, Teresa Sanchez was in Mexico for a medical procedure when her right eye began to feel unusually dry and irritated. At first, it seemed minor. She assumed her contact lens might be torn or that the switch from daily lenses to monthly ones was causing dryness. She even wondered if her body was fighting off an infection, as per CNN.

What she did not realize at the time was that a microscopic organism was slowly attacking her cornea. Over the next three months, the parasite caused irreversible damage to her vision and triggered searing pain that spread across her head.

“I couldn’t even keep the blinds open in my room,” said Sanchez, now 33 and living in Las Vegas. “Light would cause unbearable pain. That’s when I knew something was seriously wrong.”

By then, she had already seen multiple optometrists and had been misdiagnosed. Frustrated and desperate for answers, Sanchez began researching her symptoms on her own.

What Is Acanthamoeba Keratitis?

Online searches led Sanchez to a condition she had never heard of: acanthamoeba keratitis. An eye specialist later confirmed it. Keratitis refers to inflammation of the cornea, the clear, dome-shaped layer at the front of the eye that plays a central role in focusing vision. Acanthamoeba is a microscopic, single-celled organism that cannot be seen without a microscope.

According to Dr. Jacob Lorenzo-Morales, a professor of parasitology at the University of La Laguna in Spain, acanthamoeba is commonly found in soil and water. It does not require a host to survive, which makes it especially resilient.

Once the organism comes into contact with the eye, it can attach itself to the cornea. Dr. Paul Barney, an optometric physician and director at the Pacific Cataract and Laser Institute in Alaska, explained that even tiny breaks in the corneal surface can allow the parasite to burrow deeper into the eye.

Why Contact Lens Wearers Face Higher Risk?

Acanthamoeba keratitis is considered rare. Based on data from 20 countries, including the UK, India, the US, Canada and Brazil, there are more than 23,000 cases worldwide each year. Yet a striking pattern stands out. Between 85% and 95% of people who develop the infection wear contact lenses.

Contact lenses can cause microscopic abrasions on the cornea, creating an entry point for the parasite. The organism can also cling to the lens itself or become trapped between the lens and the eye, making it easier to penetrate the corneal tissue.

“If it’s not diagnosed early and treated aggressively, the outcome can be devastating,” Barney said. “The parasite feeds on the cornea, triggering inflammation and tissue damage that can lead to permanent vision loss.”

In some cases, vision can be partially restored with treatment. Others require a corneal transplant.

A Parasite Built To Survive

Treating acanthamoeba keratitis is especially difficult because the organism has strong defense mechanisms. It can sense threats and respond by forming a cyst, allowing it to lie dormant for months or even years.

This resilience means treatment often stretches over long periods and involves intense discomfort. Because the eye is extremely sensitive, patients must work closely with specialists and strictly follow treatment instructions.

Why The Condition Is Often Missed?

Early diagnosis is one of the biggest challenges Because acanthamoeba keratitis is uncommon, many optometrists may not recognize it right away. As a result, many contact lens users only learn about the condition after they develop it or come across viral videos discussing it online.

Many patients have expressed surprise that they were never clearly warned about the risks of wearing contacts while showering or swimming.

The Contact Lens Society of America emphasized that contact lenses are medical devices and require strict hygiene. This includes avoiding water exposure during swimming, showering or sleeping. The organization also stressed the importance of patients asking questions and carefully reviewing care instructions.

Acanthamoeba Keratitis: Symptoms That Mimic Other Eye Infections

In addition to severe pain and light sensitivity, acanthamoeba keratitis can cause redness, blurred vision, dryness, excessive tearing and the sensation that something is stuck in the eye.

Because these symptoms overlap with other conditions, misdiagnosis is common. Barney said the infection is frequently mistaken for herpes simplex keratitis, a major cause of infection-related blindness. In its earliest stages, it can even resemble pink eye.

That was the case for Sanchez. Her first optometrist diagnosed pink eye. The prescribed drops blurred her vision. A second optometrist suspected a bacterial infection, and while antibiotic drops offered brief relief, she soon lost vision in the affected eye.

Acanthamoeba Keratitis: How To Reduce Your Risk?

Experts stress that contact lens hygiene is critical. Always clean and store lenses using approved contact lens solution, never water. The solution in your lens case should be replaced daily. Wash and dry your hands thoroughly before handling lenses.

Sleeping in contact lenses should be avoided, as it increases dryness, irritation and the risk of corneal damage. Daily disposable lenses may lower infection risk compared to monthly lenses.

For water-based activities, glasses or prescription goggles are safer options. Some people may also consider vision correction surgery after discussing risks and suitability with a doctor.