Ozempic and Wegovy have received a lot of publicity as revolutionizing treatment options for obesity. Both medications form a class of GLP-1 receptor agonists, which mimic a hormone in the body called glucagon-like peptide-1 and are involved in the regulation of appetite and blood sugar. Indeed, in initial clinical studies, the majority of those on the drugs lost 15% to 22% of body weight, hence much optimism. For most patients, these medications are underwhelming for about 20% of patients due to minimal weight loss or other challenges.

Take a closer look at why the weight loss drugs may not work for everyone, together with what options exist when they don't deliver the expected outcomes.

Why Weight Loss Drugs May Not Work

While GLP-1 receptor agonists have produced phenomenal responses in a majority of patients, it remains a reality that these drugs work differently for different people. Here's why:

1. Genetic and Hormonal Variability

Weight loss medications interact with complex systems in the body that differ from person to person. Genetics, hormones, and individual brain responses to energy regulation play significant roles in determining how a person responds to drugs like Ozempic and Wegovy.

2. Underlying Medical Conditions

Other conditions, such as sleep apnea, may be prevalent and prevent or delay the achievement of weight loss goals. Prescription drugs like antidepressants, steroids, or contraceptives are other medications that can nullify weight loss medication benefits.

3. Unrealistic Expectations

Often, they come to these medications with enormous hopes; expecting the promised rapid and dramatic weight loss. Progress creates disappointment if it has not stalled. In patients who rigidly follow recommended lifestyle modifications, frustration and disappointment are most common.

Why it is Important to Identify Non-responders

For most patients, the effectiveness of GLP-1 receptor agonists is evident within a few weeks of treatment. Weight loss typically begins within a few weeks of initiating therapy and tends to increase with dosage. However, some patients respond very little, if at all, despite strict adherence to their regimen.

For nonresponders, this can feel like a dead end. However, understanding the unique complexities of obesity is essential. This condition stems from brain dysfunction, and the pathways that contribute to weight regulation differ among individuals.

Alternative Treatment Options

When Ozempic or Wegovy doesn’t yield desired results, there are still many paths to explore:

1. Switching to Another GLP-1 Drug

For example, some patients who don't respond well to one GLP-1 receptor agonist might find success with another drug in the same class. Newer medications, such as Zepbound, target other hormone pathways and seem promising even for those not responsive to earlier drugs.

2. Use of Older Medications

While there is much to say about newer drugs, older treatments can still be useful and work for some patients. One can also seek the help of a medical provider specializing in obesity treatments in order to identify the best alternatives.

3. Lifestyle Changes

Diet, exercise, sleep, and stress management continue to be integral components of any weight loss program. New changes may be small but can make an enormous difference in one's health and success.

4. Medical Management of Obesity

It is a complex disorder, and most patients should receive a multidisciplinary treatment. Collaboration with an obesity-aware doctor may mean access to tailored treatment plans, ranging from psychological support all the way to metabolic testing, and many others.

Why Side Effects of Weight Loss Drug Ozempic May Be a Barrier

For others, side effects like nausea, vomiting, or diarrhea hinder them from continuing with these drugs. These symptoms often reduce as the body becomes accustomed, but for some, they might be severe enough to stop treatment altogether. In those instances, alternative drugs or procedures become vital to find.

Long-term effects of Ozempic or Wegovy on the Brain

Another largely unexplored area relates to GLP-1 drugs' long-term effects on the brain's regulation of hunger and satiety. Although GLP-1 drugs suppress appetite and can lead to effective weight loss, emerging research suggests that they may also affect brain reward mechanisms, changing the way patients experience foods.

This aspect could prove of paramount significance in the future treatment of obesity. Perhaps GLP-1 receptor agonists do indeed affect and rewire the brain's reward pathways and will thus provide sustained benefits beyond discontinuation. However, more research is required to understand this phenomenon fully.

While for many, Ozempic and Wegovy have revolutionized obesity treatment, these are certainly not a one size fits all. Nonresponders need not lose hope- alternative strategies and medications abound. A consultation with an obesity expert healthcare provider is essential to put together a comprehensive, tailored treatment plan.

The route toward effective weight loss may be challenging, but with the evolution of obesity medicine and a better understanding of individual needs, there is a path forward for everyone.

The so-called “mystery virus” behind lingering sore throats, blocked noses filled with mucus, and days of exhaustion is actually well known to doctors. According to Eric Sachinwalla, medical director of infection prevention and control at Jefferson Health, the culprit is adenovirus.

What makes this virus particularly difficult to control is how tough it is. Adenovirus can survive soap and water, withstand many everyday disinfectants, and linger on contaminated surfaces for long stretches of time. Below is what experts know so far about this fast-spreading infection.

What Is Adenovirus?

Adenovirus refers to a group of common viruses that usually trigger cold- or flu-like illness. It spreads easily because it is far more resilient than many other viruses. Ordinary soap, water, and standard disinfectants do not reliably destroy it, allowing it to persist in the environment. As a result, infections often cluster in places where people spend time close together, such as daycares and military barracks. The virus spreads through the respiratory tract, can be shed in stool, and can survive for some time on contaminated surfaces, according to the CDC.

Adenovirus: What Are The Symptoms Of Adenovirus?

“Adenovirus is a typical virus that causes common cold or flu-like symptoms,” says Dr Deborah Lee at Dr Fox Online Pharmacy. That does not mean adenovirus is the same as a cold. Instead, adenovirus is one of many germs that can cause cold-like illness. A simple way to think about it is that a “cold” describes the symptoms, while adenovirus is one specific virus that can lead to them.

Symptoms can vary depending on the subtype involved. While there are more than 100 known subtypes, only 49 infect humans. Dr Lee notes that people may experience any of the following:

• Fever
• Runny nose
• Sore throat
• Swollen cervical lymph nodes in the neck
• Cough
• Shortness of breath
• Conjunctivitis
• Ear pain
• Diarrhoea
• Vomiting
• Stomach pain
• Urinary tract infection

Adenovirus? Is It Contagious?

“Adenovirus infection is highly contagious,” Dr Lee explains. “It spreads by breathing in infected droplets, by touching the virus and then rubbing the eyes, or through the faecal-oral route, often due to poor hand hygiene after using the toilet.”

She adds that the virus spreads quickly in crowded settings where people are in close contact. To eliminate adenovirus from surfaces, Dr Lee recommends stronger cleaning agents such as bleach-based solutions or hydrogen peroxide. “The virus is resistant to soap and many commonly used cleaners,” she says.

To reduce the risk of catching adenovirus or other respiratory infections currently circulating, Dr Lee advises staying away from people who are unwell. She also suggests the following precautions:

• Avoid touching your face and nose
• Use a clean tissue to blow your nose and dispose of it immediately
• Wash your hands often with soap and warm water, then dry them thoroughly, especially after using the toilet or changing nappies
• Clean children’s toys regularly
• Disinfect worktops, changing areas, toilets, and bathrooms
• Avoid sharing cups, plates, food, or towels
• Wear a mask if you need to go out while unwell
• Keep windows open and ensure rooms and workspaces are well ventilated.

As we soon step into 2026, it is time to look back at which diseases took over the world in 2025. These diseases evolved throughout the year, and led to complex challenges. Here, we explore the top 5 health crisis in 2025.

Infectious Diseases, Outbreaks, and COVID-19

This year, COVID-19 continued to make headlines, along with COVID, flu and measles too continued to infect people. In fact, new variants of COVID and flu have circulated across the world, leading to new kinds of symptoms, including razor-blade like throats in COVID-19. Influenza too surged up across US, UK, and Canada, with hospitalization rates going up. A new subclade K strain is seen responsible for this surge. Measles, too is a highly contagious, however, vaccine-preventable respiratory virus resurged this year, and this disease, which was once eliminated from the US, has come back due to lower rates of vaccination.

Tuberculosis Outbreak

A tuberculosis outbreak in the Kansas City metro area resulted in dozens of cases. This has led to two deaths, as reported by the Kansas Department of Health and Environment (KDHE). In fact, Michael A Bernstein, MD, director of pulmonary and critical care at Stamford Health said that many people assume that TB is rare and no longer a concern, however, it still remains common.

Also Read: Top 5 Infectious Diseases That Disrupted Healthcare System Worldwide In 2025

Bird Flu

In the US, the first death from bird flu was reported by the Louisiana Department of Health. The Centers for Disease Control and Prevention (CDC) reported that the individual was older than 65 years and had underlying medical conditions. That person developed severe illness and was hospitalized following the exposure to a noncommercial backyard flock and wild word. In fact, new studies have shown that bird flu viruses could have a potential risk for humans and may become next pandemic. This comes from two different studies, one done by the universities of Cambridge and Glasgow that show how avian flu strains are multiplying even when the body temperatures could hinder viruses. Whereas, another important study led by Indian scientists, by Philip Cherian and Gautam Menon of Ashoka University, published in BMC Public Health predict if H5N1 or the bird flu virus, could start spreading among humans.

Antimicrobial Resistance (AMR)

In 2025, AMR has worsened and the resistance has risen over 40% of monitored pathogen-antibiotic pairs between 2018-2023. Due to the resistance, common infections become harder to treat, especially in regions like Southeast Asia, with India facing high rates. The World Health Organization (WHO) report notes that AMR is a growing threat to global health, and draws on more than 23 million bacteriologically confirmed cases of bloodstream infections, urinary tract infections, gastrointestinal infections, and urogenital gonorrhoea.

Non Communicable Diseases or NCDs

NCDs like heart disease, cancer, diabetes, and respiratory illnesses remained a persistent global health challenge in 2025. Trends to showed a continued rise driven by unhealthy lifestyles, which included processed food, inactivity, tobacco or alcohol, and urbanization.

Dozens of norovirus outbreaks have been recorded nationwide over the past few weeks, and as people deal with intense vomiting, diarrhea, and other uncomfortable or even risky symptoms, a common question keeps coming up: why is there still no vaccine for such a widespread infection.

The Centers for Disease Control and Prevention (CDC) says norovirus cases are increasing toward the end of 2025, with higher activity reported in both the US and the UK. Health officials note that a new, highly infectious strain known as GII.17 is partly driving this rise. Because many people have little or no immunity to it, outbreaks are being seen more often in schools and shared public spaces. While overall case numbers remain within typical seasonal ranges, recent weeks have shown a clear upward trend.

What Is Norovirus?

Norovirus is an extremely contagious virus that leads to gastroenteritis. It commonly causes symptoms such as vomiting, diarrhea, nausea, and stomach cramps, and may also bring fever and body aches. It is often referred to as the ‘stomach flu,’ though it has no connection to influenza.

The virus spreads quickly through contaminated food or water, shared surfaces, or direct contact with an infected person’s vomit or stool. Crowded settings like cruise ships are especially vulnerable. Most people recover within one to three days with rest and enough fluids, according to the CDC.

Norovirus Symptoms 2025

Norovirus usually comes on suddenly, causing vomiting, watery diarrhea, nausea, and abdominal pain. Fever, headaches, and body aches are also common. Symptoms typically appear 12 to 48 hours after exposure and last for one to three days. Because it spreads so easily, infections can move fast through families and communities.

While most cases improve on their own, dehydration is a concern, so warning signs such as intense thirst or reduced urination should not be ignored, as noted by the Cleveland Clinic.

Do We Have A Norovirus Vaccine?

At present, there is no widely available vaccine for norovirus. That said, research has made meaningful strides. Experimental oral vaccines have shown encouraging results in clinical studies, suggesting they may offer protection against multiple fast-changing strains and help reduce how much virus an infected person sheds. Scientists are hopeful that an effective, broadly protective vaccine may become available in the coming years, according to the National Institutes of Health.

Why Don’t We Have a Norovirus Vaccine Yet?

Developing a vaccine for norovirus has proven especially difficult, largely because of how quickly the virus changes. “It really is evolving extremely rapidly, and that’s a big problem,” Patricia Foster, PhD, professor emerita of biology at Indiana University Bloomington, told Health.

Norovirus also exists in dozens of subtypes, with several dominant strains circulating at any given time. This is why people can catch norovirus more than once in their lives. Even if immunity develops against one strain, either after infection or through vaccination, another strain can still cause illness. Centers for Disease Control and Prevention. About norovirus.

Norovirus: Multiple Vaccines Are In The Works

Despite these obstacles, vaccine research is moving forward. Progress has accelerated in part because of newer technologies developed over the past decade. In 2016, Mary Estes, PhD, a researcher at Baylor College of Medicine, and her team found a way to grow norovirus outside the human body. This breakthrough made it possible to test vaccine approaches and treatments more effectively. This step was crucial because common lab animals like mice do not typically get sick from human norovirus.

Today, scientists are testing several experimental vaccines. One example is a 2023 vaccine developed at Washington University School of Medicine in St. Louis that combines protection against norovirus with an existing rotavirus vaccine. Several pharmaceutical companies are also developing candidates, many of which are now in clinical trials, said Amesh Adalja, MD, senior scholar at the Johns Hopkins Center for Health Security, in comments to *Health*.

HilleVax, a Boston-based company, has been testing a norovirus vaccine originally developed by Japan’s Takeda. However, that candidate did not succeed in a phase II trial in June 2024. Meanwhile, a tablet-style norovirus vaccine from San Francisco-based Vaxart has completed phase I testing. Among the most promising efforts is Moderna’s vaccine, which is currently being tested in human volunteers.

Preventing Norovirus, Even Without a Vaccine

Norovirus spreads so easily that stopping it once someone falls ill can be very challenging. This is linked to the virus’s structure. Norovirus is a nonenveloped virus, similar to polio and other stomach-related infections. Because of this, neither hand sanitizers nor soap and water actually destroy the virus, Foster explained. “Handwashing helps because you’re physically rinsing the virus away,” she said.

As a result, basic hygiene practices, especially thorough handwashing, remain some of the most effective ways to lower risk, said Ming Tan, PhD, an infectious disease researcher and associate professor of pediatrics at Cincinnati Children’s Hospital Medical Center, speaking to *Health*.

If norovirus does strike, treatment options are limited. Staying hydrated is essential to avoid complications from fluid loss. Some people may also use medicines to control nausea or diarrhea, either over the counter or by prescription, such as Zofran. If severe symptoms develop, including confusion, high fever, or intense abdominal pain, medical care should be sought right away.