Ozempic and Wegovy have received a lot of publicity as revolutionizing treatment options for obesity. Both medications form a class of GLP-1 receptor agonists, which mimic a hormone in the body called glucagon-like peptide-1 and are involved in the regulation of appetite and blood sugar. Indeed, in initial clinical studies, the majority of those on the drugs lost 15% to 22% of body weight, hence much optimism. For most patients, these medications are underwhelming for about 20% of patients due to minimal weight loss or other challenges.

Take a closer look at why the weight loss drugs may not work for everyone, together with what options exist when they don't deliver the expected outcomes.

Why Weight Loss Drugs May Not Work

While GLP-1 receptor agonists have produced phenomenal responses in a majority of patients, it remains a reality that these drugs work differently for different people. Here's why:

1. Genetic and Hormonal Variability

Weight loss medications interact with complex systems in the body that differ from person to person. Genetics, hormones, and individual brain responses to energy regulation play significant roles in determining how a person responds to drugs like Ozempic and Wegovy.

2. Underlying Medical Conditions

Other conditions, such as sleep apnea, may be prevalent and prevent or delay the achievement of weight loss goals. Prescription drugs like antidepressants, steroids, or contraceptives are other medications that can nullify weight loss medication benefits.

3. Unrealistic Expectations

Often, they come to these medications with enormous hopes; expecting the promised rapid and dramatic weight loss. Progress creates disappointment if it has not stalled. In patients who rigidly follow recommended lifestyle modifications, frustration and disappointment are most common.

Why it is Important to Identify Non-responders

For most patients, the effectiveness of GLP-1 receptor agonists is evident within a few weeks of treatment. Weight loss typically begins within a few weeks of initiating therapy and tends to increase with dosage. However, some patients respond very little, if at all, despite strict adherence to their regimen.

For nonresponders, this can feel like a dead end. However, understanding the unique complexities of obesity is essential. This condition stems from brain dysfunction, and the pathways that contribute to weight regulation differ among individuals.

Alternative Treatment Options

When Ozempic or Wegovy doesn’t yield desired results, there are still many paths to explore:

1. Switching to Another GLP-1 Drug

For example, some patients who don't respond well to one GLP-1 receptor agonist might find success with another drug in the same class. Newer medications, such as Zepbound, target other hormone pathways and seem promising even for those not responsive to earlier drugs.

2. Use of Older Medications

While there is much to say about newer drugs, older treatments can still be useful and work for some patients. One can also seek the help of a medical provider specializing in obesity treatments in order to identify the best alternatives.

3. Lifestyle Changes

Diet, exercise, sleep, and stress management continue to be integral components of any weight loss program. New changes may be small but can make an enormous difference in one's health and success.

4. Medical Management of Obesity

It is a complex disorder, and most patients should receive a multidisciplinary treatment. Collaboration with an obesity-aware doctor may mean access to tailored treatment plans, ranging from psychological support all the way to metabolic testing, and many others.

Why Side Effects of Weight Loss Drug Ozempic May Be a Barrier

For others, side effects like nausea, vomiting, or diarrhea hinder them from continuing with these drugs. These symptoms often reduce as the body becomes accustomed, but for some, they might be severe enough to stop treatment altogether. In those instances, alternative drugs or procedures become vital to find.

Long-term effects of Ozempic or Wegovy on the Brain

Another largely unexplored area relates to GLP-1 drugs' long-term effects on the brain's regulation of hunger and satiety. Although GLP-1 drugs suppress appetite and can lead to effective weight loss, emerging research suggests that they may also affect brain reward mechanisms, changing the way patients experience foods.

This aspect could prove of paramount significance in the future treatment of obesity. Perhaps GLP-1 receptor agonists do indeed affect and rewire the brain's reward pathways and will thus provide sustained benefits beyond discontinuation. However, more research is required to understand this phenomenon fully.

While for many, Ozempic and Wegovy have revolutionized obesity treatment, these are certainly not a one size fits all. Nonresponders need not lose hope- alternative strategies and medications abound. A consultation with an obesity expert healthcare provider is essential to put together a comprehensive, tailored treatment plan.

The route toward effective weight loss may be challenging, but with the evolution of obesity medicine and a better understanding of individual needs, there is a path forward for everyone.

April 2 is celebrated worldwide as “Autism Awareness Day” and April as Autism month to create awareness and promote inclusivity and acceptance in society for individuals with autism.

So what exactly is Autism, and why do we need to create a culture of awareness and acceptance?

As per DSM V (Diagnostic and Statistical Manual of Mental Disorders) criteria, in simple terms, there is poor eye contact, impaired social communication skills, repetitive patterns (certain movements or fixation on certain toys, objects), difficulties with sensory processing - extreme sensitivity to sensory inputs (dislike loud noises, sensitive to touch), etc.

As a child, these individuals may not respond to name-calling, have poor eye contact/lack gestures like pointing, etc., lack imagination in play, and may not be able to relate and respond to the emotions of others. They have set routines and dislike changes to their routines. All this can cause significant disruption to their day-to-day functioning.

This year’s theme of -Autism and Humanity- Every Life has Value” reiterates the need for inclusion of autism, ensuring equitable representation of these individuals. Ensuring that society not only recognizes them but also treats them with equal respect and dignity.

Educational Support and Inclusive Workplace

Sarva Shiksha Abhiyan (SSA) was one of the Government's flagship programs, along with Action for Autism, to disseminate information in schools regarding inclusive education for autism. Education is a key foundation to ensure children with autism get suitable opportunities as adults. Special educators, with additional support in schools, can go a long way in ensuring their potential is maximized.

Many IT giants like Microsoft, Google, and SAP encourage tapping the potential of individuals with autism and their exceptional skills. In our country, organizations and NGOs, including Action for Autism, offer training for future employment opportunities.

There is a spectrum of Autistic Spectrum Disorders (ASD) known as Asperger’s syndrome, and these individuals have normal to above average intelligence and can have some exceptional skills, and the world includes some living examples of these with a higher IQ, some of whom are the most successful and famous personalities. Even on the other end of the spectrum, autistic individuals have exceptional skills, some of which include great attention to detail, creativity, problem-solving, and lateral out-of-the-box thinking.

Options for flexible working hours (part-time), understanding their need for routines, and explaining them beforehand regarding important changes to schedules can help them adapt better to an otherwise challenging workplace.

The Need For Sensitization

Understanding individuals with autism may need little extra support, being a little flexible with time deadlines, giving simple instructions, especially written/visual ones, and allowing them time to overcome their communication barriers can go a long way in ensuring they feel heard and valued like anyone else in the workplace.

Sensitization of all major organization employees to foster a culture of acceptance and awareness, and an accessible work environment, is the need of the hour. Autistic individuals do well in a variety of job profiles, including IT, technology, finance, art and creativity, and administration.

Environmental modifications like background noise cancellation with headphones help those with sensory processing issues. At the end of the day, none of us is perfect, it's recognizing our special skills and strengthening them.

Possibilities are endless if we wish to encourage and make these individuals heard. So, let’s carry the Autism Awareness Day beyond a mere day of awareness and light it up blue. Let’s value and acknowledge them being different, but also empower them to act on their special skills to earn them a dignified place in society and the workplace.

World Autism Awareness Day is observed every year on April 2. The day is important to raise awareness about autism — a neurodevelopmental condition affecting communication, social interaction, and behavior — affecting millions of people globally.

According to the World Health Organization (WHO), one in 127 people worldwide is diagnosed with the lifelong brain health condition. It is also among the top 10 conditions contributing to health loss globally.

The first child diagnosed with autistic symptoms was Donald Grey Triplett. Labelled as Case 1, he went on to become an American banker, demonstrating that, if provided with the right and inclusive support and opportunities individuals with autism be as productive as others.

“Like anyone else, autistic people should be able to shape their own lives — and help to shape our shared future,” said

António Guterres, UN Secretary-General.

World Autism Awareness Day: Date and History

April 2 was designated as World Autism Awareness Day (WAAD) by the United Nations General Assembly in 2007.

The 2007 General Assembly resolution highlighted the need to raise public awareness of autism.

It stated that "children with disabilities should enjoy a full and decent life, in conditions which ensure dignity, promote self-reliance and facilitate the child’s active participation in the community, as well as the full enjoyment of all human rights and fundamental freedoms on an equal basis with other children".

World Autism Awareness Day: Theme

This year, World Autism Awareness Day is held under the theme "Autism and Humanity - Every Life Has Value".

The 2026 theme highlights and affirms the dignity and worth of all autistic people. While there are international human rights conventions safeguarding the rights of people with autism, they continue to face stigma, discrimination, and barriers to participation.

“Access to timely, quality health care and support services remains limited, driving inequalities across the life course," the WHO said. The global health body urged "sustained action and greater investment" to address these challenges. It also called for developing inclusive policies and services that uphold the rights of autistic people.

This year's theme, thus, is a call to action to recognize the inherent dignity and equal rights of all people with autism.

Guterres highlighted the need for "equal education, fair employment, and accessible health systems" for all persons with autism and to provide inclusive opportunities to participate and thrive, along with others.

Also read: Expert Reveals Why Childhood Autism Is Going Undetected In India

What is Autism?

The National Health Service (NHS) UK defines autism as not an illness or a medical condition with treatments or a "cure", but a developmental condition that affects how people communicate, learn, behave, and interact with others.

It is a spectrum, which means "everybody with autism is different".

People with autism spectrum disorder (ASD) may have difficulty with social interaction, exhibit atypical behavior and activities, or find it hard to communicate.

Early Signs Of Autism

Studies show that symptoms of autism are usually diagnosed within the first 3 years of birth. These include:

• Limited to zero eye contact
• Delayed responses
• Repeating words or actions such as hand-flapping
• Being strong-headed about following the same routine
• Easily annoyed, throws tantrums
• Difficulty understanding and expressing emotions
• Sensitive to certain sounds, textures, lights, or smells.

The American Heart Association (AHA), in its latest update on nutrition guidance, has urged the need to eat a diet rich in vegetables and fruits, while also making a key shift to plant-based protein from meat-based protein earlier to improve heart health.

It has also emphasized the need to reduce the intake of sugar, salt and ultra-processed foods, as well as to switch to low-fat dairy.

The scientific statement, which is issued about every five years, comes amid increasing cases of high blood pressure and obesity in the US, which can potentially lead to poor health outcomes, including deaths from cardiovascular disease and other chronic conditions.

“For healthy eating to be more attainable and sustainable, we recommend people focus on their overall eating pattern rather than specific nutrients or foods. This approach is actionable, something that can be modified as people pass through different life stages, while still adhering to the nine key features,” said Alice H. Lichtenstein, volunteer chair of the scientific statement writing committee and senior scientist.

“The guidance applies to wherever you eat: at home, school, work, restaurants, or in your community. You want to strive for progress rather than perfection. Every time you choose to make a swap for a healthier alternative, you’re making a step toward a healthier life,” added Lichtenstein, who is also senior scientist at the Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University in Boston.

The 9 Guidelines for a heart-healthy dietary pattern include:

• Maintaining a healthy body weight by balancing food intake and physical activity
• Eating plenty of vegetables and fruits
• Choose whole grains such as whole‑wheat bread, brown rice, and oatmeal over refined grains such as white bread or white rice
• Shifting from meat to plant-based sources such as legumes, including beans, peas, and lentils, along with nuts and seeds, and fish and seafood. Select low-fat or fat-free dairy products.
• Replace saturated fats with healthy unsaturated fats, including those from nuts, seeds, avocados, and non-tropical plant oils.
• Choose minimally processed foods instead of ultra-processed foods
• Limit beverages and foods with added sugars
• Choose foods low in sodium and prepare foods with minimal or no salt
• Limit intake of alcohol

Also read: AHA’s New Dyslipidemia Guidelines Stress Early Screening, Lifestyle Management

Healthy Eating Patterns From Childhood

The 2026 guidance for children recommends a heart‑healthy dietary pattern starting at 1 year of age. It urges families to play a significant role and become role models.

“Cardiovascular disease begins early in life; even prenatal factors can contribute to increased risk in children as they grow. So, it’s important that healthy eating patterns are adopted in childhood and continue throughout the entire lifespan,” Lichtenstein said.

“The best way to do that is for adults to role model heart-healthy eating patterns inside and outside the home,” she added.

Also read: Cardiovascular Diseases Lead As India’s Top Killer: US Cardiologist Points Out Risk Factors

While the updated guidance is specifically designed to improve cardiovascular health, it may also help improve other conditions like type 2 diabetes, kidney disease, some cancers, and brain health.