Ozempic and Wegovy have received a lot of publicity as revolutionizing treatment options for obesity. Both medications form a class of GLP-1 receptor agonists, which mimic a hormone in the body called glucagon-like peptide-1 and are involved in the regulation of appetite and blood sugar. Indeed, in initial clinical studies, the majority of those on the drugs lost 15% to 22% of body weight, hence much optimism. For most patients, these medications are underwhelming for about 20% of patients due to minimal weight loss or other challenges.

Take a closer look at why the weight loss drugs may not work for everyone, together with what options exist when they don't deliver the expected outcomes.

Why Weight Loss Drugs May Not Work

While GLP-1 receptor agonists have produced phenomenal responses in a majority of patients, it remains a reality that these drugs work differently for different people. Here's why:

1. Genetic and Hormonal Variability

Weight loss medications interact with complex systems in the body that differ from person to person. Genetics, hormones, and individual brain responses to energy regulation play significant roles in determining how a person responds to drugs like Ozempic and Wegovy.

2. Underlying Medical Conditions

Other conditions, such as sleep apnea, may be prevalent and prevent or delay the achievement of weight loss goals. Prescription drugs like antidepressants, steroids, or contraceptives are other medications that can nullify weight loss medication benefits.

3. Unrealistic Expectations

Often, they come to these medications with enormous hopes; expecting the promised rapid and dramatic weight loss. Progress creates disappointment if it has not stalled. In patients who rigidly follow recommended lifestyle modifications, frustration and disappointment are most common.

Why it is Important to Identify Non-responders

For most patients, the effectiveness of GLP-1 receptor agonists is evident within a few weeks of treatment. Weight loss typically begins within a few weeks of initiating therapy and tends to increase with dosage. However, some patients respond very little, if at all, despite strict adherence to their regimen.

For nonresponders, this can feel like a dead end. However, understanding the unique complexities of obesity is essential. This condition stems from brain dysfunction, and the pathways that contribute to weight regulation differ among individuals.

Alternative Treatment Options

When Ozempic or Wegovy doesn’t yield desired results, there are still many paths to explore:

1. Switching to Another GLP-1 Drug

For example, some patients who don't respond well to one GLP-1 receptor agonist might find success with another drug in the same class. Newer medications, such as Zepbound, target other hormone pathways and seem promising even for those not responsive to earlier drugs.

2. Use of Older Medications

While there is much to say about newer drugs, older treatments can still be useful and work for some patients. One can also seek the help of a medical provider specializing in obesity treatments in order to identify the best alternatives.

3. Lifestyle Changes

Diet, exercise, sleep, and stress management continue to be integral components of any weight loss program. New changes may be small but can make an enormous difference in one's health and success.

4. Medical Management of Obesity

It is a complex disorder, and most patients should receive a multidisciplinary treatment. Collaboration with an obesity-aware doctor may mean access to tailored treatment plans, ranging from psychological support all the way to metabolic testing, and many others.

Why Side Effects of Weight Loss Drug Ozempic May Be a Barrier

For others, side effects like nausea, vomiting, or diarrhea hinder them from continuing with these drugs. These symptoms often reduce as the body becomes accustomed, but for some, they might be severe enough to stop treatment altogether. In those instances, alternative drugs or procedures become vital to find.

Long-term effects of Ozempic or Wegovy on the Brain

Another largely unexplored area relates to GLP-1 drugs' long-term effects on the brain's regulation of hunger and satiety. Although GLP-1 drugs suppress appetite and can lead to effective weight loss, emerging research suggests that they may also affect brain reward mechanisms, changing the way patients experience foods.

This aspect could prove of paramount significance in the future treatment of obesity. Perhaps GLP-1 receptor agonists do indeed affect and rewire the brain's reward pathways and will thus provide sustained benefits beyond discontinuation. However, more research is required to understand this phenomenon fully.

While for many, Ozempic and Wegovy have revolutionized obesity treatment, these are certainly not a one size fits all. Nonresponders need not lose hope- alternative strategies and medications abound. A consultation with an obesity expert healthcare provider is essential to put together a comprehensive, tailored treatment plan.

The route toward effective weight loss may be challenging, but with the evolution of obesity medicine and a better understanding of individual needs, there is a path forward for everyone.

While a hickey is generally harmless, in several shocking incidents, it has led to strokes and even death.

A hickey is typically a dark red or dark purple mark on your skin caused by intense suction.

According to health experts, the strong suction from the passionate love bite leads to blood clots that travel to the brain. It then blocks a vital artery and causes a embolic stroke.

Embolic stroke is a type of ischemic stroke caused by a blood clot or debris (embolus) that forms elsewhere in the body—often the heart—and travels through the bloodstream to block a blood vessel in the brain.

The Independent reported the case of 17-year-old Julio Macias Gonzalez, who suffered convulsions while eating dinner with his family after hanging out with his 24-year-old girlfriend and later died.

In a similar case reported from New Zealand, a 44-year-old woman suffered a stroke following a hickey.

While non-fatal, the 2010 study published in the New Zealand Medical Journal reported the medical condition “a rare phenomenon.”

In yet another case, the Danish Medical Journal reported the incident of a 35-year-old woman who experienced a sudden onset of right-sided weakness due to a left middle cerebral artery stroke 12 hours after she had obtained a love bite on the left side of her neck.

“Generally speaking, hickeys are simply superficial bruising, and there’s no scientific evidence available that could inform our thinking about this situation as it relates to stroke,” Teresa Roncon, spokeswoman for the Heart and Stroke Foundation of Canada, was quoted as saying Global News.

Is It Lethal?

While it's generally harmless, in some extreme cases, it can raise the risk of damaging the carotid or vertebral artery due to extreme pressure.

The carotid arteries, one on each side of the neck, are responsible for supplying blood to the head, including the brain. Vigorous manipulation of the neck, including the action of a hickey, can cause the inner wall of the carotid artery to rupture. (This process is medically termed as carotid artery dissection).

Such a dissection is a nidus, a place where bacteria can multiply, for the formation of a blood clot. The blood clot can then get dislodged and enter the brain circulation, eventually causing a stroke.

How Can A Hickey Go Wrong?

While there is nothing wrong with giving or receiving love bites, it is imperative to note that one should not dig their teeth too deeply into the other person's neck to avoid injury and damage to sensitive structures like the carotid artery or the jugular vein (a vein that carries deoxygenated blood from the skull to the body).

While there are practically no ways to cure a hickey, you can speed up the healing process. These processes can help you expedite the process:

• Alternate Cold and Warm Compresses
• Avoid Worsening The Hickey
• Massage The Area
• Use Topical Creams.

Ten-year-old Myla from the UK's North Yorkshire, with severe eye strain, was diagnosed with a severe brain tumor that led to her death.

The young girl had been suffering from headaches and dizziness, which were dismissed as mere eye strain due to playing on her iPad too much.

Thinking that she needed eyeglasses, her parents took her for an eye appointment, where she was diagnosed with an aggressive diffuse midline glioma — a type of brain tumor.

Myla was diagnosed with a 7-10cm tumor and was rushed to Sheffield Children's Hospital for an operation to remove 60 per cent of the mass. The youngster underwent a grueling 30 rounds of radiotherapy but tragically passed away on January 15, The Mirror.co.uk reported.

Can Eye Strains Lead To Brain Tumors?

Healthandme spoke to health experts to understand the role of eye strain and brain tumors.

The health experts noted that although prolonged exposure to digital screens can raise the risk of vision problems, they cannot cause brain tumors.

"Eye strain is most commonly linked to prolonged screen use, poor ergonomics, or uncorrected vision, and in the vast majority of cases, it is not a sign of brain cancer," Dr. Parul Maheshwari Sharma, Ophthalmologist and Principal Director & HOD - at Fortis Gurugram, told HealthandMe.

"The likelihood of experiencing eye strain being an indication of brain cancer is minimal," added Dr. Mahipal Singh Sachdev, Chairman & Medical Director, Centre For Sight Group of Eye Hospitals.

The doctors explained that brain tumors are rarely present as simple eye strain; they are usually associated with additional symptoms such as:

• persistent headaches,
• double vision,
• vision loss,
• vomiting,
• neurological deficits.
• convulsions,
• vision changes.

What Is Eye Strain?

Eye strain, also referred to as digital eye strain or computer vision syndrome, is caused by staring at screens for extended periods of time and decreased blinking.

It generally occurs due to benign factors such as excessive screen time, dry eye, or uncorrected vision.

While prolonged screen use can cause discomfort, dry eyes, and temporary blurred vision, it does not lead to the development of cancer.

"There is no evidence to suggest that screen-induced eye strain can cause brain tumors," Dr Sharma said.

"Although there may be visual changes due to a tumor that involves the optic nerve or hypothalamus, simple eye strain is not indicative of brain tumors and would not be considered an early warning of a brain tumor. There is an extremely low probability that eye strain will be due to a brain tumor," Dr. Sachdev told HealthandMe.

However, the experts agreed that long screen time can lead to severe eye strain.

Red Flags One Should Not Ignore For Brain Tumors

Brain tumors are generally attributed to genetics, exposure to radiation, or other unknown factors.

Numerous types of red flags could indicate the presence of a serious neurological disorder. Some examples include

• chronic or worsening headaches, especially if severe in the morning,
• recurrent unexplained vomiting,
• seizure activity,
• sudden changes in vision, such as double vision or complete loss of vision,
• trouble speaking clearly,
• weakness in the arms or legs,
• drastic personality changes.

Higher-risk patients include:

• those with a history of radiation exposure to the brain,
• specific genetic conditions,
• those with a family history of brain cancer.

Also read: 12-Year-Old Teen Dies From Rare Brain Tumor After Unusual Early Signs, Grieving Mother Urges Parents To Watch For Subtle Symptoms

Steps to Reduce Eye Strain

To help combat eye fatigue, individuals can adopt some simple habits, such as

• Following the 20-20-20 rule: every 20 minutes, look at something 20 feet away for 20 seconds.
• Place your computer monitor at or below eye level and keep a comfortable distance from the computer.
• Adjust your screen brightness and contrast to comfortable levels and use adequate room lighting.
• Remember to blink often or use artificial tears to keep your eyes moist.
• Take screen breaks, limit the duration of time you are using your computer, or limit the continuous use of your computer.
• Make sure you are using the correct prescription glasses and consider using an anti-glare screen, which can also help relieve discomfort and protect your eyes from long-term effects.

Ladies, does it ever happen to you that you are not on your period, not PMSing, and still feel moody and upset? Well, as it turns out, experts say that there could be a very simple reason for this. According to researchers at the University of Connecticut, even mild dehydration could be responsible for mood changes in women. Not only this, even 1.36 per cent dehydration can affect your mood, ability to think and energy levels. The Daily Mail notes that a loss of 1.5 per cent of normal water volume levels in the body can be classified as mild dehydration, and its adverse effects can linger for some time.

Read more: The Health Problems Women Normalise, But Gynaecologists Do Not

How does dehydration affect women?

In women, the adverse effects of dehydration can be serious. Experts say that the effects are more intense in women, and they came to this conclusion after analysing the results of tests, which revealed that it does not matter if a person walks for 40 minutes on a treadmill or is in a state of rest — if an individual is even slightly thirsty, the adverse effects will be the same.

Research shows that even 1.36 per cent dehydration is enough to cause the following problems:

1. 8 per cent rise in hostility and anger
2. 12 per cent dip in vigour
3. 17 per cent increase in fatigue
4. 45 per cent dip in concentration
5. 19 per cent worsening of mood
6. 58 per cent dip in understanding simple tasks
7. Headaches worsening two fold

Is thirst the same as dehydration?

Lead researcher of the study, Lawrence Armstrong, noted that a sensation of thirst does not appear until a person is one or two per cent dehydrated. By then, it starts to set in and act up, adversely impacting how the mind and body perform. Dehydration can affect everyone, which is why it is just as important for people in desk jobs to stay hydrated as it is for marathon runners.

Read more: Three Health Checks Every Woman Should Do Each Month, According To Experts

In this research, experts put participants through a series of tests evaluating their concentration, vigilance, reaction time, reasoning, memory and learning. The results were then compared with those of people who were not dehydrated. In younger women, mild dehydration resulted in fatigue, headaches and concentration difficulties. Women also found basic tasks more difficult to execute than usual. On the other hand, young men noted some difficulty in performing mental tasks — they experienced anxiety, fatigue and tension in the process. Mood changes were more prominent in women than in men.