Ozempic and Wegovy have received a lot of publicity as revolutionizing treatment options for obesity. Both medications form a class of GLP-1 receptor agonists, which mimic a hormone in the body called glucagon-like peptide-1 and are involved in the regulation of appetite and blood sugar. Indeed, in initial clinical studies, the majority of those on the drugs lost 15% to 22% of body weight, hence much optimism. For most patients, these medications are underwhelming for about 20% of patients due to minimal weight loss or other challenges.

Take a closer look at why the weight loss drugs may not work for everyone, together with what options exist when they don't deliver the expected outcomes.

Why Weight Loss Drugs May Not Work

While GLP-1 receptor agonists have produced phenomenal responses in a majority of patients, it remains a reality that these drugs work differently for different people. Here's why:

1. Genetic and Hormonal Variability

Weight loss medications interact with complex systems in the body that differ from person to person. Genetics, hormones, and individual brain responses to energy regulation play significant roles in determining how a person responds to drugs like Ozempic and Wegovy.

2. Underlying Medical Conditions

Other conditions, such as sleep apnea, may be prevalent and prevent or delay the achievement of weight loss goals. Prescription drugs like antidepressants, steroids, or contraceptives are other medications that can nullify weight loss medication benefits.

3. Unrealistic Expectations

Often, they come to these medications with enormous hopes; expecting the promised rapid and dramatic weight loss. Progress creates disappointment if it has not stalled. In patients who rigidly follow recommended lifestyle modifications, frustration and disappointment are most common.

Why it is Important to Identify Non-responders

For most patients, the effectiveness of GLP-1 receptor agonists is evident within a few weeks of treatment. Weight loss typically begins within a few weeks of initiating therapy and tends to increase with dosage. However, some patients respond very little, if at all, despite strict adherence to their regimen.

For nonresponders, this can feel like a dead end. However, understanding the unique complexities of obesity is essential. This condition stems from brain dysfunction, and the pathways that contribute to weight regulation differ among individuals.

Alternative Treatment Options

When Ozempic or Wegovy doesn’t yield desired results, there are still many paths to explore:

1. Switching to Another GLP-1 Drug

For example, some patients who don't respond well to one GLP-1 receptor agonist might find success with another drug in the same class. Newer medications, such as Zepbound, target other hormone pathways and seem promising even for those not responsive to earlier drugs.

2. Use of Older Medications

While there is much to say about newer drugs, older treatments can still be useful and work for some patients. One can also seek the help of a medical provider specializing in obesity treatments in order to identify the best alternatives.

3. Lifestyle Changes

Diet, exercise, sleep, and stress management continue to be integral components of any weight loss program. New changes may be small but can make an enormous difference in one's health and success.

4. Medical Management of Obesity

It is a complex disorder, and most patients should receive a multidisciplinary treatment. Collaboration with an obesity-aware doctor may mean access to tailored treatment plans, ranging from psychological support all the way to metabolic testing, and many others.

Why Side Effects of Weight Loss Drug Ozempic May Be a Barrier

For others, side effects like nausea, vomiting, or diarrhea hinder them from continuing with these drugs. These symptoms often reduce as the body becomes accustomed, but for some, they might be severe enough to stop treatment altogether. In those instances, alternative drugs or procedures become vital to find.

Long-term effects of Ozempic or Wegovy on the Brain

Another largely unexplored area relates to GLP-1 drugs' long-term effects on the brain's regulation of hunger and satiety. Although GLP-1 drugs suppress appetite and can lead to effective weight loss, emerging research suggests that they may also affect brain reward mechanisms, changing the way patients experience foods.

This aspect could prove of paramount significance in the future treatment of obesity. Perhaps GLP-1 receptor agonists do indeed affect and rewire the brain's reward pathways and will thus provide sustained benefits beyond discontinuation. However, more research is required to understand this phenomenon fully.

While for many, Ozempic and Wegovy have revolutionized obesity treatment, these are certainly not a one size fits all. Nonresponders need not lose hope- alternative strategies and medications abound. A consultation with an obesity expert healthcare provider is essential to put together a comprehensive, tailored treatment plan.

The route toward effective weight loss may be challenging, but with the evolution of obesity medicine and a better understanding of individual needs, there is a path forward for everyone.

Scromiting is taking up the space in headlines now. Before 2025 comes to an end, this single symptom caused by a deadly cannabis condition has got everyone talking about it.

The deadly cannabis hyperemesis syndrome (CHS), is now formally designated by the World Health Organization (WHO), and the unique and unusual symptom is scromiting: a mix of screaming and vomiting. Thanks to social media, this word is making a buzz and have distorted what people should actually know about the condition.

The WHO has formally named CHS in October, which was after a decision adopted by the Centers for Disease Control and Prevention (CDC) that will help doctors track the prevalence of the condition and get a better picture of adverse events.

Scromiting and CHS: How Did It Make A Big News?

The conversation reignited after a study published in the Journal of the American Medical Association in late November reported that CHS cases remain elevated. The study noted that cyclic vomiting is a related symptom and confirmed that emergency department visits tied to CHS saw a notable rise between 2016 and 2022, particularly in 2020 and 2021. During those two years, researchers identified 188 million emergency department visits among adults aged 18 to 35, with CHS appearing more frequently among heavy cannabis users.

The Origin Of CHS

CHS was first identified in Australia in 2004, yet nearly two decades later it remains poorly understood. It typically affects people who use marijuana daily or near daily for more than a year, leading to episodes of severe nausea, repeated vomiting, abdominal pain and a compulsive desire to take extremely hot showers or baths. Many patients report that heat temporarily eases their symptoms, although doctors say the relief is often short-lived.

What Are The Doctors Saying?

Dr Sam Wang, a pediatric emergency medicine specialist and toxicologist at Children’s Hospital Colorado, described treating patients who arrive exhausted and doubled over in pain after hours of vomiting, as reported by CNN. Many tell doctors they tried taking a scalding hot shower before coming to the hospital but found it offered little relief. The National Institutes of Health has said this hot water reliance appears to be a learned behavior that can become a compulsion.

Despite the surge in awareness, the term “scromiting,” a blend of screaming and vomiting, has sparked its own controversy. Some social media users argue the sudden buzz is exaggerated or anti-cannabis fearmongering. Others say the phenomenon has been known for years. Natashia Swalve, a neuroscience professor at Grand Valley State University, told Axios that “scromiting” is not a clinical term, just a catchy label that gains traction every few years. She warned that sensational language fuels confusion at a time when misinformation about CHS is already widespread.

Health experts say CHS episodes can last for days and recovery may take weeks or even months, depending on overall health, eating habits and whether the person stops using marijuana. Continuing to use cannabis can quickly trigger symptoms again. A study from George Washington University found that nearly half of surveyed patients had been hospitalized at least once because of CHS, and many reported using marijuana more than five times a day before symptoms began. Starting cannabis at an early age was linked to a higher likelihood of developing the condition.

The renewed scrutiny of CHS comes as the United States faces rising infections from norovirus, sometimes called “winter vomiting disease,” another illness known for causing sudden, intense vomiting. While unrelated, the overlapping symptoms have added to public confusion around what exactly is driving widespread reports of stomach distress.

Researchers emphasize that CHS is real, although many questions remain unanswered, including why hot showers feel soothing and how much cannabis use puts someone at risk. They say more clinical awareness is urgently needed. Better screening for cannabis use and recognizing symptom patterns could help reduce misdiagnosis and guide patients toward the only proven treatment: stopping marijuana use.

For years, people have joked about how women seem to enjoy showers that could probably cook noodles. If you are someone who loves cranking up the water temperature until the bathroom looks like a steam room, you may have wondered whether there is an actual reason behind it. According to UK surgeon and content creator Dr Karan Rajan, the answer lies in biology. Women are not simply choosing scalding showers for fun. Their bodies are wired differently, and that affects how they experience temperature.

Higher Core Body Temperature

Dr Rajan explains that, on average, women have a slightly higher core body temperature than men. It might sound like this would keep them warmer, but in reality, it does the opposite. When the core is warm but the surrounding environment is cool, that contrast makes cold air feel even colder. So a mildly chilly room may feel more uncomfortable for women, leading them to turn to hotter showers to compensate.

This idea has gone viral online. In a popular TikTok clip, creator couple Micah and Sarah joked about preparing for a shared shower. Micah pretended to train for the extreme heat by dipping his hand in boiling water. The internet quickly chimed in with comments like “My husband says I am training for hell” and “He calls it lobster time”. The jokes were relatable because many couples experience this temperature divide, but not many knew the science behind it until now.

Hormones Add to the Chill

Hormones play a major role too. Estrogen affects blood flow to the extremities, which includes hands, feet and even earlobes. Research shows that women’s extremities can be up to three degrees colder than men’s. Dr Rajan points out that this becomes more noticeable during ovulation when estrogen levels peak. Women on hormonal birth control may also experience increased sensitivity because estrogen stays higher for longer periods.

So even when the core stays warm, the toes and fingers may feel unusually cold. A very warm shower becomes a quick and comforting fix for this temperature imbalance.

Lower Metabolic Rates

Another biological factor is metabolic rate. Women generally have a lower resting metabolic rate than men, meaning they produce less body heat throughout the day. This naturally makes them feel colder and more drawn to hotter water while bathing. Women also tend to have more body fat and less muscle mass, which influences how the body responds to temperature changes.

What Doctors Say

Australian GP Dr Jasmina Dedic Hagan supports these findings, as reported in Body and Soul. She explains that women typically have warmer cores, cooler skin, and a higher layer of insulating fat around the body. On top of that, they have reduced circulation in the extremities because the body prioritises keeping reproductive organs warm. With less muscle mass, the body’s heat-producing brown fat does not function in quite the same way as it does in men.

So Is It Just Preference?

Not entirely. While some women truly enjoy the sensation of a very hot shower, much of it is tied to biology. From hormones to metabolism to circulation, several factors work together to make warmer showers feel soothing and sometimes even necessary. So the next time someone teases you about loving lava-level water, you can tell them it is simply science at work.

When you are burning up, even a simple shower can feel confusing. Should you cool your body quickly with cold water or soothe your aches with something warm? Fever is a natural defense mechanism, but the symptoms it brings can make you feel miserable. The right water temperature can help ease discomfort and support your recovery.

Below is a simple breakdown of how fever affects your body, followed by practical shower tips and additional ways to safely bring your temperature down.

How Fever Resets Your Body’s Thermostat

During an infection, your immune system releases chemicals called pyrogens. These signals tell the hypothalamus, which is your internal thermostat, to raise your core temperature. The added heat slows the growth of certain viruses and bacteria and helps immune cells work more efficiently.

This temperature rise is why you feel:

• Chills as your body works to reach the new set point
• Sweating when the fever begins to settle
• Faster heart rate and quicker breathing, which increase fluid loss

Knowing this matters because water that is too cold can trigger intense shivering, which drives your temperature higher. Water that is too hot can widen your blood vessels and increase sweating, which may worsen dehydration.

Cold, Lukewarm, or Hot: Which Shower Helps Most?

Each water temperature works differently with a fever. Understanding these differences helps you choose what your body needs at that moment.

Cold showers cool your skin quickly. They may feel refreshing if you are overheated, but they often trigger shivering. That shivering can raise your core temperature and is especially risky in children.

Lukewarm or tepid showers are the safest choice for most people with fever. This temperature allows gentle heat loss through the skin without causing shivering. It helps you cool down gradually while keeping your body comfortable.

Warm or hot showers can help relieve muscle aches or sinus congestion, especially for adults. However, they can increase sweating and may slightly raise your temperature. Avoid them if you are already overheated or dehydrated.

Simple Shower Tips When You Have a Fever

• Start with lukewarm water to safely reduce temperature and ease discomfort.
• If you feel flushed and sweaty, splash cold water only on pulse points such as the wrists and neck.
• Use warm showers only for congestion relief and follow up with hydration and light clothing.
• If you feel dizzy, sit on a chair outside the shower and let steam fill the bathroom while you take a gentle sponge bath.

Other Safe Ways to Bring Down a Fever

Rest

Your body is already working hard to fight the infection. Light activity can raise your temperature further, so give yourself time to rest and recover.

Stay Hydrated

Fever increases the risk of dehydration, especially if you have vomiting or a poor appetite. Sip water, oral rehydration solutions, or electrolyte drinks. Chilled fluids can also help lower your temperature.

Stay Cool

Keep your room slightly cool and wear loose, breathable clothing. If you have chills, use a light blanket but avoid overheating. You can place a cool cloth on your forehead or under the arms for short intervals.

Medication

Over the counter fever reducers like acetaminophen and ibuprofen can safely lower fever. Always follow dosage guidelines. Avoid aspirin in children because it can lead to Reye's syndrome.

What Not to Do

• Do not take cold showers or ice baths because they trigger shivering and can raise your temperature.
• Avoid alcohol rubs since the alcohol can be absorbed through the skin.
• Do not take extra doses of fever medicine thinking it will work faster.
• Always read medication labels carefully to avoid accidental overdosing.