Most people are aware of type 1 and type 2 diabetes, but did you know there is a type 3 diabetes as well! It is a more obscure term. Although it is not an accepted medical diagnosis, type 3 diabetes has been discussed in the literature as a possible relationship between insulin resistance in the brain and Alzheimer's disease. This link has been described to help explain how metabolic disorders impact brain health, causing cognitive decline and dementia.

What is Type 3 Diabetes?

Type 3 diabetes is more of a misnomer because it should not be confused with type 3c diabetes, which relates to pancreatic dysfunction. The term "type 3 diabetes," on the other hand, has been loosely used by some scientists to analogously propose that Alzheimer's disease is strongly implicated with insulin resistance in the brain.

This concept was conceptualized by Dr. Suzanne de la Monte and Dr. Jack Wands of Brown University in the year 2008. This hypothesis postulated that Alzheimer's disease may be called type 3 diabetes for it bears many similarities with glucose metabolism disorder type 2 diabetes. Their concept arises from the basic principle that insulin is fundamental to blood sugar regulation, but it is also the case with the brain. When brain cells become insulin-resistant, they lose access to glucose, impairing their function.

Research published in the Journal of Diabetes Science and Technology supports this hypothesis by indicating that insulin resistance can be a significant contributor to the occurrence of dementia, also referred to as Alzheimer's. The symptoms of memory loss and diminished reasoning are associated with impaired glucose metabolism in the body, especially in the cerebral tissue.

Symptoms of Type 3 Diabetes

Although type 3 diabetes is not a "medical term," its symptoms correlate well with Alzheimer's diseases that are known to reduce the ability to think in an efficient manner and bring down brain health. These signs are:

- Loss of memory, especially short-term.

- Poor judgment and judgment ability

- Failure in recognizing people or places familiar once.

- Failure in the process of reading, writing or processing numbers

- Anxiety, agitation, or mood changes.

- Disorganized thoughts or confusion

- Lack of impulse control

As the disease advances, patients may be afflicted with severe complications including an inability to swallow or control their bodily functions. In the final stages, most patients die from fatal complications such as aspiration pneumonia.

Causes of Type 3 Diabetes

This may not be well understood with regards to type 3 diabetes, or the exact link between insulin resistance and Alzheimer's disease. Some identified contributing factors include the following:

1. Insulin Resistance

Insulin acts as an important regulatory mechanism of brain functions such as memory and cognition. The reduction in insulin signaling may impair metabolism of brain cells, thus bringing about neurodegeneration.

2. Type 2 Diabetes

These diseases show a strong relationship and those individuals diagnosed with type 2 diabetes have double chances of getting Alzheimer's. In the two, the main causes can be chronic inflammation, oxidative stress, and a defect in glucose metabolism.

3. Environmental and Lifestyle Factors

Insulin resistance associated with obesity, stress, and an unhealthy diet is considered a cause that may increase the chances of Alzheimer's disease.

Researches in Frontiers in Neuroscience and The Lancet Neurology have also highlighted that drugs used for antidiabetic medication may be crucial for the prevention or at least slowing down the course of Alzheimer's.

Treatments for Type 3 Diabetes

In 2022, in a study in Pharmaceuticals, researchers studied biomarker uptake in brain regions implicated in the faulty uptake and metabolism of blood sugar in Alzheimer’s patients.

Emerging Therapies

Research into such treatments as intranasal insulin has also been promising. Intranasal delivery of insulin directly to the brain has been reported to enhance glucose uptake by brain cells, improve memory, and boost cognitive performance. While such clinical trials have been shown to be successful, additional research is needed for safety and efficacy.

Medications

For patients being aggressive or agitated, antipsychotic drugs may be prescribed; however, therapies such as cognitive rehabilitation as well as cognitive stimulation therapy serve to preserve memory and executive function.

Lifestyle Interventions

Diet, exercise, and stress management are critical in preventing and managing insulin resistance. A review in the Journal of Alzheimer's Disease also highlighted the benefits of Kirtan Kriya meditation, which can regulate genes involved in insulin and glucose metabolism, improve sleep, and reduce inflammation.

Can Type 3 Diabetes Be Prevented?

Although type 3 diabetes is not officially recognized, its connection to Alzheimer’s disease underscores the importance of proactive measures for brain health. Some prevention strategies include:

1. Healthy Diet

Consuming a balanced diet rich in antioxidants, whole grains, and healthy fats may support brain health.

2. Regular Exercise

Physical activity improves insulin sensitivity, reduces inflammation, and enhances overall metabolic health.

3. Stress Reduction

Mindfulness practices, including meditation, have been shown to lower stress levels, which can reduce the risk of cognitive decline.

The term type 3 diabetes brings out the complex relationship between metabolic disorders and brain health. Even though it is not a recognized medical condition, the concept emphasizes the crucial role of insulin in brain function and its possible contribution to Alzheimer's disease. Continued research will hopefully provide hope for therapies such as intranasal insulin and lifestyle modifications.

H1N1 cases are rising across several Indian states, with infections, hospitalisations and deaths being reported. However, the Indian Council of Medical Research (ICMR) has said the increase is not unusual and that no new strain is driving the current rise.

The ICMR has clarified that the circulating Influenza A (H1N1) pdm09 viruses have been present in India since 2025 and that no new strain has been identified.

ICMR Director General Dr Rajiv Bahl has said H1N1 accounts for nearly 98% of Influenza A cases currently detected in India, while H3N2 accounts for around 2-3% of cases.

Health authorities have urged people not to panic but to remain alert, particularly if symptoms become severe or persist.

States Reporting H1N1 and Influenza Cases

Delhi

Delhi has reported 138 new H1N1 cases in the last 24 hours, taking the cumulative number of H1N1 cases this year to 2,446, the Delhi government said on Wednesday.

The total number of Influenza A cases has reached 3,177 as the city continues to see a rise in seasonal influenza infections.

Maharashtra

Maharashtra is witnessing a significant surge in Influenza A (H1N1) cases, with the 2026 tally already surpassing the total recorded throughout the previous year.

As of August 21, the state had reported 1,109 H1N1 cases, compared with 942 cases in all of 2025.

Mumbai and Pune remain the primary centres of reported infections, together accounting for around 65% of the state's total cases.

Uttarakhand

Uttarakhand has reported 49 confirmed H1N1 cases and five deaths as of late August 2026, prompting a heightened health alert.

The state has also reported 103 dengue cases, including 49 confirmed cases from Dehradun.

Karnataka

Karnataka has recorded 4,212 laboratory-confirmed influenza cases, including H1N1 cases, across 32 districts since January, with the majority of active cases concentrated in Bengaluru.

That compares with 4,583 cases in 2025 and 3,903 cases in 2024.

Kerala

Kerala has reported 7,421 influenza cases and 88 deaths this year, with most fatalities reported among people over 50.

These figures refer to influenza overall and should not be treated as H1N1-specific cases or deaths.

What Does H1N1 Usually Feel Like?

According to the Ministry of Health and Family Welfare, fever and systemic symptoms generally last around three days, although they can persist longer. Cough and weakness may continue even after the fever settles.

Dr GC Khilnani, Chairman, PSRI Institute of Pulmonary, Critical Care & Sleep Medicine, PSRI Hospital, New Delhi, told HealthandMe that common symptoms include body aches, sore throat, headache and fever, which can sometimes be high-grade.

Nausea, vomiting and occasional chest pain may also occur. The illness can be relatively short-lived and may last around three to five days in many cases.

H1N1 Red Flags You Shouldn't Miss

Certain symptoms should not be managed casually at home. These include:

Fever accompanied by breathlessness

Chest pain

Increasing weakness

Confusion

Bluish lips or nails

A noticeable fall in oxygen levels

These symptoms may indicate more serious respiratory involvement and require prompt medical assessment.

Who Needs to Be Particularly Cautious?

Although influenza can affect people of any age, certain groups are more likely to develop severe illness. These include young children, older adults, pregnant women and people with asthma or other chronic lung conditions, heart disease, diabetes or kidney disorders.

People with weakened immune systems are also at greater risk of complications. This includes cancer patients, particularly those receiving chemotherapy or other treatments that suppress immunity.

“An oncology patient may not always develop a dramatic set of symptoms at the beginning. Chemotherapy can affect blood counts and reduce the body's ability to mount an effective response to infection. That is why a new fever or respiratory symptom during treatment deserves earlier attention than it might in an otherwise healthy person,” says Dr Ankur Nandan Varshney, Sr. Medical Oncologist, Medanta Hospital, Noida, told HealthandMe.

Which Tests Are Actually Needed?

Not everyone with a cough and fever needs an H1N1 test. Testing is generally guided by symptoms, severity, risk factors and the clinical situation.

If the doctor suspects influenza and confirmation is needed, testing is usually done using a respiratory sample collected through a nasal or nasopharyngeal swab. Molecular methods such as RT-PCR can identify the influenza virus and help confirm the diagnosis.

“For a cancer patient, I would not look at the H1N1 report in isolation. A CBC with differential, particularly the neutrophil count, can be clinically important during chemotherapy. Depending on symptoms, oxygen saturation and examination findings, the doctor may also recommend a chest X-ray or CT scan to look for pneumonia or other lung complications,” explains Dr Varshney.

Don't Wait for Symptoms to Become Severe

People who are more susceptible to complications should seek medical advice early rather than relying on repeated home tests or taking medicines without guidance.

While many seasonal influenza infections improve on their own, individuals with weakened immunity or other underlying risk factors need closer monitoring and should contact their doctor promptly if symptoms appear or start getting worse.

“Especially in patients undergoing cancer treatment, the aim should be to identify deterioration early rather than wait until breathing becomes difficult,” said Dr Varshney.

How Can You Prevent H1N1 Infection?

Simple precautions can help reduce the spread of seasonal influenza:

Wash your hands regularly with soap and water.

Cover your mouth and nose when coughing or sneezing.

Avoid close contact with people who are sick.

Stay home when experiencing flu-like symptoms.

Improve ventilation in shared indoor spaces.

Avoid touching your eyes, nose and mouth with unwashed hands.

Amid a significant surge in H1N1 cases in India, experts say the flu can affect more than just the respiratory system—it can also cause eye symptoms.

H1N1, a strain of influenza A virus, is usually associated with fever, cough, sore throat, body ache, fatigue and other respiratory symptoms. It spreads mainly through respiratory droplets when an infected person coughs, sneezes or talks. However, influenza can sometimes affect areas beyond the respiratory system, including the eyes.

Some people may develop watering, redness, irritation, photophobia or dryness during a flu infection. While these symptoms may improve as the flu resolves, sudden changes in vision should not be ignored.

How Does H1N1 Affect the Eyes?

Speaking to HealthandMe, Dr. Sfurti Maan, Senior Consultant, Internal Medicine, Shalby International Hospital, said that in most cases, eye symptoms are mild and settle with appropriate care. One of the more noticeable problems is viral conjunctivitis.

“The eyes may become red and watery, with burning, irritation or mild discharge. More intense inflammation may cause swelling of the eyelids or conjunctiva,” the expert said.

A person may also develop light sensitivity or general discomfort in the eyes.

Another possible finding is a bright-red patch on the white portion of the eye. This is called a subconjunctival hemorrhage and can sometimes occur after severe coughing or vomiting.

When Should You See A Doctor?

Most H1N1-related eye problems are limited to conjunctivitis. However, rare cases of deeper eye inflammation, including uveitis, retinitis and optic nerve involvement, have also been reported. These complications are uncommon but can affect vision.

“If someone has influenza and develops persistent blurred vision, severe eye pain, marked sensitivity to light or a sudden drop in vision, that should not be treated as routine conjunctivitis. These symptoms need an eye examination,” Dr. Sfurti said.

Dr. Poninder Kumar Dogra, Senior Consultant, Ophthalmology at ShardaCare – Healthcity, said people with influenza should see an ophthalmologist if they experience:

• Sudden loss of vision

• Blurred or double vision

• Flashes of light

• An increase in eye floaters

• Vision problems when looking close up

• Substantial eye pain

• Intense redness or redness around the eye

• An unusual increase in photophobia with discharge

What About Contact Lens Wearers?

Contact lens wearers may develop eye pain, redness and changes in vision. Contacts should not be worn, and an eye examination should be arranged until the eyes have been investigated and an ophthalmic practitioner says they can be worn again.

Fluid loss, dehydration and fever during the flu can cause dryness and discomfort. Various medications may also cause dry eyes.

How Can You Prevent Eye Symptoms?

Annual flu vaccination is one of the key ways to reduce the risk of influenza. Others include:

• Good hand hygiene,
• covering the mouth and nose while coughing or sneezing,
• avoiding close contact with people who are sick
• staying home when unwell.

Dr. Sfurti advised people with flu symptoms to also avoid touching or rubbing their eyes, particularly with unwashed hands. If conjunctivitis is present, sharing towels, tissues, pillows or personal eye-care products should also be avoided.

“It is important not to panic just because H1N1 can affect the eyes. Serious ocular complications are very rare. The important thing is to recognise the warning signs. If there are only redness, watering and mild irritation, it is usually not a reason for alarm. But any significant change in vision deserves prompt medical attention.”

Dr. Poninder told HealthandMe that antibiotic drops or steroids should never be self-prescribed without seeing an ophthalmologist, as they can potentially delay diagnosis or affect the diagnosis of another condition.

Redness with a slight amount of discharge, discomfort or irritation with transient dryness that gradually resolves may not require an ophthalmologist referral. However, sudden loss of vision, intense pain, extreme redness and progressing inflammation should be checked.

It usually starts small, a sting during a bowel movement, a smear of blood on tissue, an ache that feels like it will pass on its own. The instinct is to go for an old antiseptic ointment or a painkiller left over from something else. For a few days, it works. The pain eases, the bleeding stops showing up, and the natural conclusion follows, it's healed. Then, weeks or months later, it comes back. The same cream goes on, the same tablet gets swallowed, and the cycle repeats, each round quietly convincing the patient that this is something to manage rather than consulting a doctor.

Why Repeated Self-Medication Can Delay The Right Diagnosis?

That cycle is where the real cost shows up. Every round of self-medication is also a round of postponed diagnosis, pain, bleeding, or discharge gets suppressed instead of investigated, and a fissure or fistula that could have been caught and treated early is left to become chronic instead. It's a more common pattern than it should be: a 2025 study on haemorrhoidal symptoms found that only 30.8% of patients had sought medical advice at all, citing embarrassment and fear of invasive examinations as the main barriers.

An anal fissure is a small tear in the lining of the anal canal. Many improve with the right conservative care, soft stools, and medication suited to that specific case. What concerns me is when a patient keeps self-treating through repeated episodes. A fissure that keeps coming back usually means something underlying hasn't been resolved, however many times the symptoms have been calmed down.

Also read: Ulcerative Colitis vs Crohn’s Disease: 8 Key Differences Every Person Must Know

Why Recurring Symptoms Should Not Be Self-Diagnosed?

Another common mistake is assuming that recurring symptoms are caused by the same condition as before. A fissure two years ago cleared up with a certain cream, so when something similar happens now, the same tube comes back out. But recurring symptoms don't automatically mean the same condition has returned. Fissures, fistulas, and haemorrhoids can look remarkably alike from the outside, which is exactly why self-diagnosis is unreliable more often than people expect.

None of this means every twinge needs a procedure, or that patients should panic at the first uncomfortable day. Plenty of cases genuinely settle with timely, conservative management. The real skill is recognising when self-care stops being enough.

If pain, bleeding, swelling, pus, or discharge keeps returning or never fully clears, that's the signal to get it looked at, not medicated into silence again. A proper specialist assessment can pin down what's actually happening and whether the right next step is conservative treatment, medication, or a procedure.

For anyone dealing with a fissure or a fistula, the goal isn't just to make the symptom vanish for a while. It's understanding why it showed up in the first place. Temporary relief feels like progress, but it isn't recovery.