Most people are aware of type 1 and type 2 diabetes, but did you know there is a type 3 diabetes as well! It is a more obscure term. Although it is not an accepted medical diagnosis, type 3 diabetes has been discussed in the literature as a possible relationship between insulin resistance in the brain and Alzheimer's disease. This link has been described to help explain how metabolic disorders impact brain health, causing cognitive decline and dementia.

What is Type 3 Diabetes?

Type 3 diabetes is more of a misnomer because it should not be confused with type 3c diabetes, which relates to pancreatic dysfunction. The term "type 3 diabetes," on the other hand, has been loosely used by some scientists to analogously propose that Alzheimer's disease is strongly implicated with insulin resistance in the brain.

This concept was conceptualized by Dr. Suzanne de la Monte and Dr. Jack Wands of Brown University in the year 2008. This hypothesis postulated that Alzheimer's disease may be called type 3 diabetes for it bears many similarities with glucose metabolism disorder type 2 diabetes. Their concept arises from the basic principle that insulin is fundamental to blood sugar regulation, but it is also the case with the brain. When brain cells become insulin-resistant, they lose access to glucose, impairing their function.

Research published in the Journal of Diabetes Science and Technology supports this hypothesis by indicating that insulin resistance can be a significant contributor to the occurrence of dementia, also referred to as Alzheimer's. The symptoms of memory loss and diminished reasoning are associated with impaired glucose metabolism in the body, especially in the cerebral tissue.

Symptoms of Type 3 Diabetes

Although type 3 diabetes is not a "medical term," its symptoms correlate well with Alzheimer's diseases that are known to reduce the ability to think in an efficient manner and bring down brain health. These signs are:

- Loss of memory, especially short-term.

- Poor judgment and judgment ability

- Failure in recognizing people or places familiar once.

- Failure in the process of reading, writing or processing numbers

- Anxiety, agitation, or mood changes.

- Disorganized thoughts or confusion

- Lack of impulse control

As the disease advances, patients may be afflicted with severe complications including an inability to swallow or control their bodily functions. In the final stages, most patients die from fatal complications such as aspiration pneumonia.

Causes of Type 3 Diabetes

This may not be well understood with regards to type 3 diabetes, or the exact link between insulin resistance and Alzheimer's disease. Some identified contributing factors include the following:

1. Insulin Resistance

Insulin acts as an important regulatory mechanism of brain functions such as memory and cognition. The reduction in insulin signaling may impair metabolism of brain cells, thus bringing about neurodegeneration.

2. Type 2 Diabetes

These diseases show a strong relationship and those individuals diagnosed with type 2 diabetes have double chances of getting Alzheimer's. In the two, the main causes can be chronic inflammation, oxidative stress, and a defect in glucose metabolism.

3. Environmental and Lifestyle Factors

Insulin resistance associated with obesity, stress, and an unhealthy diet is considered a cause that may increase the chances of Alzheimer's disease.

Researches in Frontiers in Neuroscience and The Lancet Neurology have also highlighted that drugs used for antidiabetic medication may be crucial for the prevention or at least slowing down the course of Alzheimer's.

Treatments for Type 3 Diabetes

In 2022, in a study in Pharmaceuticals, researchers studied biomarker uptake in brain regions implicated in the faulty uptake and metabolism of blood sugar in Alzheimer’s patients.

Emerging Therapies

Research into such treatments as intranasal insulin has also been promising. Intranasal delivery of insulin directly to the brain has been reported to enhance glucose uptake by brain cells, improve memory, and boost cognitive performance. While such clinical trials have been shown to be successful, additional research is needed for safety and efficacy.

Medications

For patients being aggressive or agitated, antipsychotic drugs may be prescribed; however, therapies such as cognitive rehabilitation as well as cognitive stimulation therapy serve to preserve memory and executive function.

Lifestyle Interventions

Diet, exercise, and stress management are critical in preventing and managing insulin resistance. A review in the Journal of Alzheimer's Disease also highlighted the benefits of Kirtan Kriya meditation, which can regulate genes involved in insulin and glucose metabolism, improve sleep, and reduce inflammation.

Can Type 3 Diabetes Be Prevented?

Although type 3 diabetes is not officially recognized, its connection to Alzheimer’s disease underscores the importance of proactive measures for brain health. Some prevention strategies include:

1. Healthy Diet

Consuming a balanced diet rich in antioxidants, whole grains, and healthy fats may support brain health.

2. Regular Exercise

Physical activity improves insulin sensitivity, reduces inflammation, and enhances overall metabolic health.

3. Stress Reduction

Mindfulness practices, including meditation, have been shown to lower stress levels, which can reduce the risk of cognitive decline.

The term type 3 diabetes brings out the complex relationship between metabolic disorders and brain health. Even though it is not a recognized medical condition, the concept emphasizes the crucial role of insulin in brain function and its possible contribution to Alzheimer's disease. Continued research will hopefully provide hope for therapies such as intranasal insulin and lifestyle modifications.

Ten-year-old Myla from the UK's North Yorkshire, with severe eye strain, was diagnosed with a severe brain tumor that led to her death.

The young girl had been suffering from headaches and dizziness, which were dismissed as mere eye strain due to playing on her iPad too much.

Thinking that she needed eyeglasses, her parents took her for an eye appointment, where she was diagnosed with an aggressive diffuse midline glioma — a type of brain tumor.

Myla was diagnosed with a 7-10cm tumor and was rushed to Sheffield Children's Hospital for an operation to remove 60 per cent of the mass. The youngster underwent a grueling 30 rounds of radiotherapy but tragically passed away on January 15, The Mirror.co.uk reported.

Can Eye Strains Lead To Brain Tumors?

Healthandme spoke to health experts to understand the role of eye strain and brain tumors.

The health experts noted that although prolonged exposure to digital screens can raise the risk of vision problems, they cannot cause brain tumors.

"Eye strain is most commonly linked to prolonged screen use, poor ergonomics, or uncorrected vision, and in the vast majority of cases, it is not a sign of brain cancer," Dr. Parul Maheshwari Sharma, Ophthalmologist and Principal Director & HOD - at Fortis Gurugram, told HealthandMe.

"The likelihood of experiencing eye strain being an indication of brain cancer is minimal," added Dr. Mahipal Singh Sachdev, Chairman & Medical Director, Centre For Sight Group of Eye Hospitals.

The doctors explained that brain tumors are rarely present as simple eye strain; they are usually associated with additional symptoms such as:

• persistent headaches,
• double vision,
• vision loss,
• vomiting,
• neurological deficits.
• convulsions,
• vision changes.

What Is Eye Strain?

Eye strain, also referred to as digital eye strain or computer vision syndrome, is caused by staring at screens for extended periods of time and decreased blinking.

It generally occurs due to benign factors such as excessive screen time, dry eye, or uncorrected vision.

While prolonged screen use can cause discomfort, dry eyes, and temporary blurred vision, it does not lead to the development of cancer.

"There is no evidence to suggest that screen-induced eye strain can cause brain tumors," Dr Sharma said.

"Although there may be visual changes due to a tumor that involves the optic nerve or hypothalamus, simple eye strain is not indicative of brain tumors and would not be considered an early warning of a brain tumor. There is an extremely low probability that eye strain will be due to a brain tumor," Dr. Sachdev told HealthandMe.

However, the experts agreed that long screen time can lead to severe eye strain.

Red Flags One Should Not Ignore For Brain Tumors

Brain tumors are generally attributed to genetics, exposure to radiation, or other unknown factors.

Numerous types of red flags could indicate the presence of a serious neurological disorder. Some examples include

• chronic or worsening headaches, especially if severe in the morning,
• recurrent unexplained vomiting,
• seizure activity,
• sudden changes in vision, such as double vision or complete loss of vision,
• trouble speaking clearly,
• weakness in the arms or legs,
• drastic personality changes.

Higher-risk patients include:

• those with a history of radiation exposure to the brain,
• specific genetic conditions,
• those with a family history of brain cancer.

Also read: 12-Year-Old Teen Dies From Rare Brain Tumor After Unusual Early Signs, Grieving Mother Urges Parents To Watch For Subtle Symptoms

Steps to Reduce Eye Strain

To help combat eye fatigue, individuals can adopt some simple habits, such as

• Following the 20-20-20 rule: every 20 minutes, look at something 20 feet away for 20 seconds.
• Place your computer monitor at or below eye level and keep a comfortable distance from the computer.
• Adjust your screen brightness and contrast to comfortable levels and use adequate room lighting.
• Remember to blink often or use artificial tears to keep your eyes moist.
• Take screen breaks, limit the duration of time you are using your computer, or limit the continuous use of your computer.
• Make sure you are using the correct prescription glasses and consider using an anti-glare screen, which can also help relieve discomfort and protect your eyes from long-term effects.

Ladies, does it ever happen to you that you are not on your period, not PMSing, and still feel moody and upset? Well, as it turns out, experts say that there could be a very simple reason for this. According to researchers at the University of Connecticut, even mild dehydration could be responsible for mood changes in women. Not only this, even 1.36 per cent dehydration can affect your mood, ability to think and energy levels. The Daily Mail notes that a loss of 1.5 per cent of normal water volume levels in the body can be classified as mild dehydration, and its adverse effects can linger for some time.

Read more: The Health Problems Women Normalise, But Gynaecologists Do Not

How does dehydration affect women?

In women, the adverse effects of dehydration can be serious. Experts say that the effects are more intense in women, and they came to this conclusion after analysing the results of tests, which revealed that it does not matter if a person walks for 40 minutes on a treadmill or is in a state of rest — if an individual is even slightly thirsty, the adverse effects will be the same.

Research shows that even 1.36 per cent dehydration is enough to cause the following problems:

1. 8 per cent rise in hostility and anger
2. 12 per cent dip in vigour
3. 17 per cent increase in fatigue
4. 45 per cent dip in concentration
5. 19 per cent worsening of mood
6. 58 per cent dip in understanding simple tasks
7. Headaches worsening two fold

Is thirst the same as dehydration?

Lead researcher of the study, Lawrence Armstrong, noted that a sensation of thirst does not appear until a person is one or two per cent dehydrated. By then, it starts to set in and act up, adversely impacting how the mind and body perform. Dehydration can affect everyone, which is why it is just as important for people in desk jobs to stay hydrated as it is for marathon runners.

Read more: Three Health Checks Every Woman Should Do Each Month, According To Experts

In this research, experts put participants through a series of tests evaluating their concentration, vigilance, reaction time, reasoning, memory and learning. The results were then compared with those of people who were not dehydrated. In younger women, mild dehydration resulted in fatigue, headaches and concentration difficulties. Women also found basic tasks more difficult to execute than usual. On the other hand, young men noted some difficulty in performing mental tasks — they experienced anxiety, fatigue and tension in the process. Mood changes were more prominent in women than in men.

The oral microbiome is the community of bacteria, fungi, and other microorganisms that naturally live in the mouth — on the teeth, gums, tongue, and cheeks. More than

700 species are known to exist, most of which are harmless and many beneficial.

However, problems arise when harmful bacteria outnumber protective ones, leading to gum inflammation or periodontal disease. During pregnancy, hormonal changes increase blood flow to the gums and alter immune responses. As a result, many women notice bleeding, swelling, or sensitivity in the gums — a condition known as pregnancy gingivitis.

This is common and reflects physiological changes rather than poor hygiene.

The Mouth's Connection To The Placenta

Pregnancy is a systemic state in which the immune system, circulation, and inflammation are closely interconnected. Chronic gum inflammation can release inflammatory mediators into the bloodstream.

In research settings, certain oral bacteria have also been detected in placental tissues from complicated pregnancies. This suggests a biological link between oral health and

placental function, although the exact pathways are still being studied.

Importantly, this relationship reflects association rather than direct causation.

Why Does Placental Health Matter?

The placenta is an active organ that regulates oxygen and nutrient transfer, hormone production, and immune protection for the developing baby.

Healthy placental development supports:

• Efficient oxygen and nutrient delivery
• Balanced hormone production
• Protection against infections
• Steady fetal growth

What Changes In Oral Health Are Normal During Pregnancy?

Up to 60–75 percent of pregnant women experience some degree of gum inflammation. Common changes include:

• Bleeding while brushing
• Swollen or tender gums
• Increased plaque buildup
• Persistent bad breath

Can Oral Health Really Affect Pregnancy Outcomes?

Research from India and globally shows associations between periodontal disease and higher risks of preterm birth, low birth weight, and preeclampsia. Meta-analyses

suggest a modest increase in risk (around 1.5–2 times).

However, pregnancy complications are multifactorial. Oral disease alone does not directly cause these outcomes. Genetics, nutrition, metabolic health, and placental

biology all play important roles.

Treating gum disease improves oral health and reduces inflammation, though studies show mixed evidence on whether it directly lowers preterm birth risk. The goal is

prevention, awareness, and overall maternal health.

How Do You Support Healthy Oral Microbiome During Pregnancy?

Daily oral care:

• Brush twice daily with gentle pressure
• Use a soft-bristled toothbrush
• Clean between teeth once daily
• Rinse your mouth after vomiting to protect enamel

• Calcium-rich foods like curd and ragi support dental health
• Vitamin C from amla, guava, and citrus helps gum healing
• Fibre-rich foods support saliva flow and microbial balance
• Hydration and lifestyle
• Drink adequate water
• Limit frequent sugary snacks
• Avoid tobacco in all forms

Pregnancy already carries emotional and physical changes, and dental symptoms can add anxiety. Support from partners and family members helps reduce mental load.

Stress can influence immunity and inflammation. Adequate rest, gentle activity such as walking or prenatal yoga, and open communication with healthcare providers

support both oral and overall health.

Warning Signs: When Should You Contact A Doctor Or Dentist?

Seek professional advice if you notice:

• Severe tooth pain or swelling
• Pus, fever, or difficulty chewing
• Bad breath that does not improve
• Persistent gum bleeding for two weeks

Pregnancy is a time when different systems of the body work in close coordination. Oral health, immune balance, and placental function are part of the same continuum.

Gentle attention to gum health is not about perfection. It is about creating supportive conditions for a healthy pregnancy and a healthy baby.