Most people are aware of type 1 and type 2 diabetes, but did you know there is a type 3 diabetes as well! It is a more obscure term. Although it is not an accepted medical diagnosis, type 3 diabetes has been discussed in the literature as a possible relationship between insulin resistance in the brain and Alzheimer's disease. This link has been described to help explain how metabolic disorders impact brain health, causing cognitive decline and dementia.

What is Type 3 Diabetes?

Type 3 diabetes is more of a misnomer because it should not be confused with type 3c diabetes, which relates to pancreatic dysfunction. The term "type 3 diabetes," on the other hand, has been loosely used by some scientists to analogously propose that Alzheimer's disease is strongly implicated with insulin resistance in the brain.

This concept was conceptualized by Dr. Suzanne de la Monte and Dr. Jack Wands of Brown University in the year 2008. This hypothesis postulated that Alzheimer's disease may be called type 3 diabetes for it bears many similarities with glucose metabolism disorder type 2 diabetes. Their concept arises from the basic principle that insulin is fundamental to blood sugar regulation, but it is also the case with the brain. When brain cells become insulin-resistant, they lose access to glucose, impairing their function.

Research published in the Journal of Diabetes Science and Technology supports this hypothesis by indicating that insulin resistance can be a significant contributor to the occurrence of dementia, also referred to as Alzheimer's. The symptoms of memory loss and diminished reasoning are associated with impaired glucose metabolism in the body, especially in the cerebral tissue.

Symptoms of Type 3 Diabetes

Although type 3 diabetes is not a "medical term," its symptoms correlate well with Alzheimer's diseases that are known to reduce the ability to think in an efficient manner and bring down brain health. These signs are:

- Loss of memory, especially short-term.

- Poor judgment and judgment ability

- Failure in recognizing people or places familiar once.

- Failure in the process of reading, writing or processing numbers

- Anxiety, agitation, or mood changes.

- Disorganized thoughts or confusion

- Lack of impulse control

As the disease advances, patients may be afflicted with severe complications including an inability to swallow or control their bodily functions. In the final stages, most patients die from fatal complications such as aspiration pneumonia.

Causes of Type 3 Diabetes

This may not be well understood with regards to type 3 diabetes, or the exact link between insulin resistance and Alzheimer's disease. Some identified contributing factors include the following:

1. Insulin Resistance

Insulin acts as an important regulatory mechanism of brain functions such as memory and cognition. The reduction in insulin signaling may impair metabolism of brain cells, thus bringing about neurodegeneration.

2. Type 2 Diabetes

These diseases show a strong relationship and those individuals diagnosed with type 2 diabetes have double chances of getting Alzheimer's. In the two, the main causes can be chronic inflammation, oxidative stress, and a defect in glucose metabolism.

3. Environmental and Lifestyle Factors

Insulin resistance associated with obesity, stress, and an unhealthy diet is considered a cause that may increase the chances of Alzheimer's disease.

Researches in Frontiers in Neuroscience and The Lancet Neurology have also highlighted that drugs used for antidiabetic medication may be crucial for the prevention or at least slowing down the course of Alzheimer's.

Treatments for Type 3 Diabetes

In 2022, in a study in Pharmaceuticals, researchers studied biomarker uptake in brain regions implicated in the faulty uptake and metabolism of blood sugar in Alzheimer’s patients.

Emerging Therapies

Research into such treatments as intranasal insulin has also been promising. Intranasal delivery of insulin directly to the brain has been reported to enhance glucose uptake by brain cells, improve memory, and boost cognitive performance. While such clinical trials have been shown to be successful, additional research is needed for safety and efficacy.

Medications

For patients being aggressive or agitated, antipsychotic drugs may be prescribed; however, therapies such as cognitive rehabilitation as well as cognitive stimulation therapy serve to preserve memory and executive function.

Lifestyle Interventions

Diet, exercise, and stress management are critical in preventing and managing insulin resistance. A review in the Journal of Alzheimer's Disease also highlighted the benefits of Kirtan Kriya meditation, which can regulate genes involved in insulin and glucose metabolism, improve sleep, and reduce inflammation.

Can Type 3 Diabetes Be Prevented?

Although type 3 diabetes is not officially recognized, its connection to Alzheimer’s disease underscores the importance of proactive measures for brain health. Some prevention strategies include:

1. Healthy Diet

Consuming a balanced diet rich in antioxidants, whole grains, and healthy fats may support brain health.

2. Regular Exercise

Physical activity improves insulin sensitivity, reduces inflammation, and enhances overall metabolic health.

3. Stress Reduction

Mindfulness practices, including meditation, have been shown to lower stress levels, which can reduce the risk of cognitive decline.

The term type 3 diabetes brings out the complex relationship between metabolic disorders and brain health. Even though it is not a recognized medical condition, the concept emphasizes the crucial role of insulin in brain function and its possible contribution to Alzheimer's disease. Continued research will hopefully provide hope for therapies such as intranasal insulin and lifestyle modifications.

Vitamin deficiencies are often brushed aside as minor nutritional gaps. Many people assume they can be fixed later or ignored until something feels seriously wrong. According to Dr Prabhat Ranjan Sinha, Senior Consultant, Internal Medicine at Aakash Healthcare, this casual attitude can be risky, especially when it comes to Vitamin D3 and Vitamin B12. Both nutrients play a central role in bone strength, nerve function, immunity, and energy levels. When their levels drop, the damage may build quietly and surface only when daily life starts to feel difficult.

Vitamin D3 and Vitamin B12 are essential for overall wellbeing. Their deficiency may not cause obvious symptoms at first, but over time they can affect how the body functions, how often a person falls sick, and how energetic or mentally sharp they feel.

Vitamin B12 And D3 Deficiencies: The Sunshine Vitamin And Why It Matters

Vitamin D3, often called the sunshine vitamin, is produced by the body when skin is exposed to sunlight. Along with calcium, it helps maintain strong bones and reduces the risk of fractures. Low levels of Vitamin D3 can weaken muscles, increase the risk of falls, and raise the chances of bone disorders such as osteoporosis. In children, severe deficiency can lead to rickets, a condition that affects normal bone growth.

Dr Sinha explains that Vitamin D3 does more than support bone health. It also plays a key role in immune function. People with low levels may fall sick more often and take longer to recover from infections. Research has also linked deficiency to higher levels of inflammation in the body.

Despite living in a country with abundant sunlight, Vitamin D3 deficiency is widespread. Urban lifestyles keep many people indoors for long hours. Regular use of sunscreen, limited outdoor activity, and aging all reduce the body’s ability to produce and absorb this vitamin. Diet alone rarely provides enough Vitamin D3, which is why deficiency remains common even among people who eat well.

Vitamin B12 And Its Silent Impact

Vitamin B12 is equally important but often overlooked. It is essential for nerve health, brain function, and the production of healthy red blood cells. Unlike some deficiencies that show early warning signs, B12 deficiency tends to develop slowly. Its symptoms are often mistaken for stress, aging, or routine fatigue.

Low Vitamin B12 levels can cause weakness, persistent tiredness, tingling or numbness in the hands and feet, memory problems, mood changes, and difficulty concentrating. Over time, untreated deficiency can lead to nerve damage and anemia.

Certain groups are at higher risk. Vegetarians and vegans often do not get enough B12 because it is mainly found in animal-based foods. Older adults may struggle to absorb B12 due to reduced stomach acid. People with digestive disorders and those taking long-term acid-reducing medications are also more vulnerable.

Why These Deficiencies Are Missed?

One of the biggest challenges with Vitamin D3 and B12 deficiencies is that their symptoms overlap with many common health complaints. Ongoing fatigue, joint pain, low mood, or frequent illness are often blamed on work stress, poor sleep, or lifestyle habits. As a result, people delay medical advice until symptoms start interfering with everyday life.

Dr Sinha notes that this delay can make recovery slower and complications more likely.

Vitamin B12 And D3 Deficiencies Diagnosis And Timely Care

Simple blood tests can accurately detect Vitamin D3 and B12 deficiencies. However, many people only get tested once symptoms become severe. Early diagnosis allows for timely treatment, which may include supplements, dietary changes, and lifestyle adjustments under medical guidance.

Addressing these deficiencies early is one of the simplest ways to protect long-term health. Adequate sunlight exposure, balanced nutrition, and routine screening can help maintain healthy levels. Taking Vitamin D3 and B12 deficiencies seriously is a small step that can prevent lasting health problems and support healthier aging.

As winter approaches, many people notice an increase in sinus- and ear-related issues. Symptoms such as nasal congestion, facial pressure, headaches, ear pain, and dizziness become more frequent during this season. According to Dr. Swapnil Brajpuriya, Associate Director & Head Unit II – ENT at Asian Hospital, the combination of cold air, low humidity, and sudden temperature changes are the main reasons why sinus and ear problems worsen in winter.

Why Does Cold Air Cause Sinus Blockage?

The sinuses are air-filled cavities within the facial bones that connect to the nose and play a key role in the breathing process. During winter, the cold, dry air dries out the nasal lining, causing the mucus to thicken. Thickened mucus slows down normal sinus drainage, leading to congestion and blockage.

Dr. Brajpuriya explains, “In winter, the nasal mucous membrane tends to dry out, preventing proper drainage of mucus from the sinuses. This leads to congestion and sinus blockage.”

The Link Between Ear Heaviness, Headache, and Dizziness

The sinuses and ears are connected via the Eustachian tube, which regulates pressure between the middle ear and the environment. When sinus inflammation or blockage occurs, it can create pressure in the ears, causing a feeling of fullness, reduced hearing, headaches, and sometimes dizziness.

“Sinus infections can block the Eustachian tube, causing pressure buildup inside the ear. This pressure is often responsible for the headaches and dizziness experienced by patients,” says Dr. Brajpuriya.

Why Are Infections More Common in Winter?

Winter months often mean spending more time indoors in closed, crowded spaces, which increases the risk of viral and bacterial infections spreading. Additionally, colder temperatures and seasonal changes can weaken the immune system, making common colds and flu more likely to develop into sinusitis or middle ear infections.

Dr. Brajpuriya adds, “If a cold or flu is not treated promptly, it can progress to a sinus or middle ear infection, particularly in children and the elderly.”

Who Should Be Extra Careful?

Certain groups are more susceptible to sinus and ear problems during winter. People with allergies, asthma, frequent colds, weak immunity, or pre-existing sinus conditions need to be extra vigilant. Smokers are also at higher risk, as smoke can irritate the nasal and sinus lining, exacerbating congestion and inflammation.

Sinus Treatment and Prevention Tips

To manage and prevent winter-related sinus and ear issues, Dr. Brajpuriya recommends the following precautions:

• Keep your nose and ears protected from cold air using scarves or masks.
• Stay hydrated by drinking plenty of water to keep mucus thin.
• Minimise exposure to dust and allergens indoors.
• Seek medical advice if nasal congestion, ear pain, or dizziness persists for more than a few days.

He emphasizes, “Neglecting sinus and ear problems can lead to chronic infections. Timely treatment and proper care are essential to prevent complications.”

Cold air, dry weather, and viral or bacterial infections are the key factors behind the increase in sinus and ear problems during winter. With simple preventive measures, adequate hydration, protecting the nose and ears, and seeking early medical care, most people can manage these seasonal issues effectively and reduce the risk of complications.

A pharmacist has raised concerns for an estimated 4.8 million people in the UK who may be taking medicines such as diazepam or alprazolam. Fresh findings from Oxford Online Pharmacy suggest that one in five adults has obtained prescription-only drugs through illegal means. Anti-anxiety medicines top the list. Based on current population estimates, this could involve up to 4.8 million adults.

Another 10 percent of respondents said they had been offered medicines from unlicensed and unlawful sources, including online sellers, salons, corner shops, or even friends and family, although they chose not to take them.

As part of the study, a nationally representative group of UK adults was asked whether they had bought, received, or been offered medication from an unlicensed source. Among those who said yes, more than a third, around 35 percent, reported obtaining anti-anxiety medicines. These included selective serotonin reuptake inhibitors (SSRIs), serotonin-norepinephrine reuptake inhibitors (SNRIs), and benzodiazepines such as Valium (diazepam) and Xanax (alprazolam), according to a report by the Mirror.

What Are Diazepam And Alprazolam Used For?

Diazepam, sold under the brand name Valium, and alprazolam, commonly known as Xanax, belong to a group of medicines called benzodiazepines. They work by calming activity in the brain and are mainly prescribed to manage anxiety. Diazepam is also used to treat seizures, muscle spasms, and symptoms of alcohol withdrawal.

Alprazolam, on the other hand, is more commonly prescribed for panic disorder. Diazepam stays in the body for longer, which makes it useful in withdrawal treatment, while alprazolam acts more quickly and is often chosen for sudden panic symptoms. Both medicines slow down the central nervous system to ease anxiety, but because of their effects and differences in how long they last, they should only be used under close medical guidance, as per Medicine Net.

Diazepam And Alprazolam: Why Are Doctors Warning Against It?

Kiran Jones, a clinical pharmacist at Oxford Online Pharmacy, has issued a strong warning for anyone thinking about using, or already using, anti-anxiety medicines sourced from the black market. “Anxiety is the most common mental health condition worldwide. At any given time, around 4 to 5 percent of people are living with an anxiety disorder. With such high numbers, it is not surprising that there is a growing illegal market for anti-anxiety drugs alongside those prescribed by qualified healthcare professionals. However, this trend is deeply worrying,” Jones said.

She explained that some benzodiazepines bought illegally are made to look like genuine prescription medicines but are actually counterfeit. These fake pills may contain extremely dangerous or even fatal substances, including synthetic opioids such as fentanyl. There is also a significant risk of addiction with these medicines, especially when they are taken over long periods. Over time, the body can develop tolerance, meaning higher doses are needed to achieve the same effect, which can quickly lead to dependence.

According to doctors and NHS guidance, there are several red flags people should be aware of:

Medication Appearance

If you have previously taken anti-anxiety medication, you may notice differences in the size or shape of tablets compared to what you were originally prescribed. If you are unfamiliar with the medicine, it is important to check online what the genuine product should look like and what the usual dosages are. You might also spot spelling mistakes in the drug name, manufacturer details, or listed ingredients, as well as differences in packaging design.

As per Mirror, these are often clear warning signs of a fake product. Proper packaging should always be sealed. If it appears opened, tampered with, or simply seems off, you should not take the medicine.

Medication Quality

Genuine medicines are produced to a consistent standard and should look uniform. Tablets should not be cracked, unevenly coated, or crumble easily when touched. Any signs of mould inside blister packs or containers should be treated as a serious warning sign.

You Have To Pay In Cash Or Via Bank Transfer

Reputable pharmacies and healthcare providers use secure and traceable payment systems. Requests for cash payments or bank transfers are commonly used by illegal sellers to avoid being identified and to keep transactions untraceable.

This lack of traceability makes it much harder to report scams, track down sellers, or get help if something goes wrong. If you come across an online provider and are unsure whether it is legitimate, you should check whether it is registered with the General Pharmaceutical Council before making any purchase. The UK government’s FakeMeds campaign also offers practical guidance on how to identify suspicious online sellers.

Disclaimer: This article is for general information only and should not be taken as medical advice. Always consult a qualified doctor, pharmacist, or healthcare professional before starting, stopping, or changing any medication, especially if you have an existing medical condition, are pregnant, breastfeeding, or taking other drugs.