Most people are aware of type 1 and type 2 diabetes, but did you know there is a type 3 diabetes as well! It is a more obscure term. Although it is not an accepted medical diagnosis, type 3 diabetes has been discussed in the literature as a possible relationship between insulin resistance in the brain and Alzheimer's disease. This link has been described to help explain how metabolic disorders impact brain health, causing cognitive decline and dementia.

What is Type 3 Diabetes?

Type 3 diabetes is more of a misnomer because it should not be confused with type 3c diabetes, which relates to pancreatic dysfunction. The term "type 3 diabetes," on the other hand, has been loosely used by some scientists to analogously propose that Alzheimer's disease is strongly implicated with insulin resistance in the brain.

This concept was conceptualized by Dr. Suzanne de la Monte and Dr. Jack Wands of Brown University in the year 2008. This hypothesis postulated that Alzheimer's disease may be called type 3 diabetes for it bears many similarities with glucose metabolism disorder type 2 diabetes. Their concept arises from the basic principle that insulin is fundamental to blood sugar regulation, but it is also the case with the brain. When brain cells become insulin-resistant, they lose access to glucose, impairing their function.

Research published in the Journal of Diabetes Science and Technology supports this hypothesis by indicating that insulin resistance can be a significant contributor to the occurrence of dementia, also referred to as Alzheimer's. The symptoms of memory loss and diminished reasoning are associated with impaired glucose metabolism in the body, especially in the cerebral tissue.

Symptoms of Type 3 Diabetes

Although type 3 diabetes is not a "medical term," its symptoms correlate well with Alzheimer's diseases that are known to reduce the ability to think in an efficient manner and bring down brain health. These signs are:

- Loss of memory, especially short-term.

- Poor judgment and judgment ability

- Failure in recognizing people or places familiar once.

- Failure in the process of reading, writing or processing numbers

- Anxiety, agitation, or mood changes.

- Disorganized thoughts or confusion

- Lack of impulse control

As the disease advances, patients may be afflicted with severe complications including an inability to swallow or control their bodily functions. In the final stages, most patients die from fatal complications such as aspiration pneumonia.

Causes of Type 3 Diabetes

This may not be well understood with regards to type 3 diabetes, or the exact link between insulin resistance and Alzheimer's disease. Some identified contributing factors include the following:

1. Insulin Resistance

Insulin acts as an important regulatory mechanism of brain functions such as memory and cognition. The reduction in insulin signaling may impair metabolism of brain cells, thus bringing about neurodegeneration.

2. Type 2 Diabetes

These diseases show a strong relationship and those individuals diagnosed with type 2 diabetes have double chances of getting Alzheimer's. In the two, the main causes can be chronic inflammation, oxidative stress, and a defect in glucose metabolism.

3. Environmental and Lifestyle Factors

Insulin resistance associated with obesity, stress, and an unhealthy diet is considered a cause that may increase the chances of Alzheimer's disease.

Researches in Frontiers in Neuroscience and The Lancet Neurology have also highlighted that drugs used for antidiabetic medication may be crucial for the prevention or at least slowing down the course of Alzheimer's.

Treatments for Type 3 Diabetes

In 2022, in a study in Pharmaceuticals, researchers studied biomarker uptake in brain regions implicated in the faulty uptake and metabolism of blood sugar in Alzheimer’s patients.

Emerging Therapies

Research into such treatments as intranasal insulin has also been promising. Intranasal delivery of insulin directly to the brain has been reported to enhance glucose uptake by brain cells, improve memory, and boost cognitive performance. While such clinical trials have been shown to be successful, additional research is needed for safety and efficacy.

Medications

For patients being aggressive or agitated, antipsychotic drugs may be prescribed; however, therapies such as cognitive rehabilitation as well as cognitive stimulation therapy serve to preserve memory and executive function.

Lifestyle Interventions

Diet, exercise, and stress management are critical in preventing and managing insulin resistance. A review in the Journal of Alzheimer's Disease also highlighted the benefits of Kirtan Kriya meditation, which can regulate genes involved in insulin and glucose metabolism, improve sleep, and reduce inflammation.

Can Type 3 Diabetes Be Prevented?

Although type 3 diabetes is not officially recognized, its connection to Alzheimer’s disease underscores the importance of proactive measures for brain health. Some prevention strategies include:

1. Healthy Diet

Consuming a balanced diet rich in antioxidants, whole grains, and healthy fats may support brain health.

2. Regular Exercise

Physical activity improves insulin sensitivity, reduces inflammation, and enhances overall metabolic health.

3. Stress Reduction

Mindfulness practices, including meditation, have been shown to lower stress levels, which can reduce the risk of cognitive decline.

The term type 3 diabetes brings out the complex relationship between metabolic disorders and brain health. Even though it is not a recognized medical condition, the concept emphasizes the crucial role of insulin in brain function and its possible contribution to Alzheimer's disease. Continued research will hopefully provide hope for therapies such as intranasal insulin and lifestyle modifications.

US President Donald Trump's attempt to clarify the meaning of "sea" while discussing drug smuggling has again raised concerns of dementia.

While the 79-year-old President rambled between “sea and see” in the middle of discussing drug problems in the US, social media went rife with the rumor of his cognitive decline.

"Drugs coming by sea meaning coming by water. A lot of people don’t know what I mean by sea. They think I mean vision. I’m talking about sea like the sea," he said. He was speaking at the White House, while hosting law enforcement officials for a dinner in the Rose Garden in celebration of National Police Week.

His comments were called out by social media as his apparently worsening cognitive capabilities.

"When he says 'a lot of people' he means 'me.' His cognitive issues are a crisis," one social media user declared, while another admitted, "He’s getting worse."

Trump has spoken on sea and see, during a maternal healthcare event last week, where he also referred to himself as the “father of fertility.”

Earlier, speaking at the White House Small Business Summit, Trump said he has taken the Montreal Cognitive Assessment three times and “aced each one,” claiming a doctor told him it was the first time they had seen a perfect score, The Daily Beast reported.

The US President said he answered the test questions easily, suggesting he is cognitively in good condition—a claim that critics have repeatedly questioned.

“The first question is very easy,” he said. “You have a lion, a bear, an alligator, and a—what’s another good…? A squirrel. Which is the squirrel?” He added that the difficulty increases as the test progresses. “By the time you get to the middle, they’re very tough.”

However, the test’s creator, Canadian neurologist Ziad Nasreddine, has challenged Trump’s claims. “It wasn’t designed to be a test of IQ,” he told nine.com.au. “It was designed to assess normal cognitive performance.”

Experts Claim Trump's Mental Health Is Deteriorating

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A group of medical experts, including neurologists, psychiatrists, and other physicians, has sounded the alarm over what they’ve described as Trump’s deteriorating mental health.

The experts have not specifically examined Trump face-to-face. But, they analyzed Trump's statements and behaviors over the past year, and stated that he’s “mentally unfit” and must be removed from office “with the greatest urgency” amid the escalating tension around the world, according to their statement published in The BMJ.

“It is our professional opinion that they (Trump's statements) reflect a rapidly worsening, reality-untethered, increasingly dangerous decline,” the experts said.

They also listed some of Trump’s observable serious medical issues, such as “Marked deterioration in cognitive functioning, evidenced by disorganized and tangential speech, rambling digressions, factual confusions, unexplained sudden changes of course in strategic matters, both national and international, episodes of apparent somnolence during critical public proceedings.”

Read More:PCOD vs PCOS vs PMOS: Why The Condition’s Name Has Changed Over Time

What The White House Says

The White House has continued to say that Trump remains in strong health.

In October 2025, White House physician Captain Sean Barbabella said the president “continues to demonstrate excellent overall health,” AOl.com reported.

"President Trump’s sharpness, unmatched energy, and historic accessibility stand in stark contrast to what we saw during the last administration when Democrats and other lunatics intentionally covered up Joe Biden’s serious mental and physical decline from the American people,” White House spokesman Davis Ingle was quoted as saying to The Daily Beast.

From Polycystic Ovarian Disease (PCOD) to Polycystic Ovary Syndrome (PCOS) and now Polyendocrine Metabolic Ovarian Syndrome (PMOS) — confused about what the changing terminology means for women’s health and treatment?

What was once seen mainly as a reproductive or ovarian disorder is now being recognized as a complex hormonal and metabolic condition that can affect everything from periods and fertility to weight, insulin resistance, heart health, skin, and mental well-being.

To better understand the distinction between the three, let’s look at how the condition has evolved.

The condition, involving irregular periods, infertility, excess facial hair, and enlarged ovaries containing multiple cysts, was first identified as an ovarian or reproductive disorder in the 1930s by American gynecologists Dr. Irving Stein and Dr. Michael Leventhal. It became known as Stein-Leventhal Syndrome.

Over the years, the term PCOD became widely used, especially in countries like India. The name focused mainly on the presence of multiple ovarian cysts seen on ultrasound scans. It was considered a “disease” affecting ovulation and fertility.

Further, in the 1980s and 1990s, experts discovered that the condition involved hormonal imbalances, insulin resistance, weight gain, diabetes risk, and heart health concerns, among others.

Because it affected multiple body systems, PCOS became the medically preferred global term. The word “syndrome” was used to describe a group of related symptoms rather than a single disease.

However, many experts argued that the name still overemphasized ovarian cysts and fertility, and in 2012, the US National Institutes of Health (NIH) officially recommended changing the name, saying it was misleading because:

• Not all women with the condition have cysts
• Ovarian cysts alone are not enough for diagnosis
• The name ignores the metabolic and hormonal aspects

In 2026, global experts publishing in The Lancet proposed the new name -- PMOS – for the condition affecting more than 170 million women worldwide.

The new term PMOS acknowledges that the condition involves:

• Endocrine health
• Metabolic health
• Reproductive health
• Dermatological health
• Psychological health.

What Does PMOS Mean?

Also read: PCOS Is Now PMOS: What The Name Change Means For Millions Of Women

The new name aims to explain the condition more accurately and comprehensively.

Polyendocrine means it affects multiple hormones in the body.

Metabolic refers to issues linked to weight, insulin, blood sugar, and heart health.

Ovarian highlights its impact on ovulation and reproductive health.

Syndrome refers to a group of symptoms occurring together.

In simple terms, PMOS is a hormonal and metabolic condition that can affect periods, fertility, skin, mood, weight, and long-term health.

What The Name Change Means For Women

Speaking to HealthandMe, Dr Monika Bhatia Director — Obstetrics & Gynaecology Robotic and Laparoscopic Surgeon Cloudnine Group of Hospitals, said that the earlier name was misleading because the "cysts" in PCOS are not real cysts — they are simply small, arrested follicles.

While the name has changed, the message remains the same.

“Behind every diagnosis is a woman trying to understand her body, hormones, emotions, and health. While this condition may affect periods, fertility, metabolism, skin, weight, or mental well-being differently, one thing remains common — it is manageable with the right guidance,” she said.

The core treatment stays the same as the guidelines for treatment have not changed, but the approach becomes wider.

“So instead of just treating the periods, PMOS is now managed as a whole-body condition involving a multidisciplinary team”.

Will there be any change to evaluation?

Dr Muskaan Chhabra, Fertility Specialist, Birla Fertility & IVF, Lajpat Nagar, told HealthandMe that the new name –PMOS- correctly acknowledges that this is a multisystem condition involving complex interactions between insulin, androgens, and neuroendocrine hormones.

In PMOS, the ovaries are one of several systems involved rather than the primary site of the problem.

This “opens the door to more comprehensive clinical evaluation, earlier and more accurate diagnosis, and treatment approaches that address the full hormonal and metabolic picture rather than a narrow reproductive one,” Dr Muskaan said. It will also “drive more integrated and personalized care”.

Hantavirus has the potential to linger indoors and spread through contaminated dust, especially in rodent-infested, poorly ventilated spaces, according to infectious disease expert Dr. Vasant C. Nagvekar.

So far, 11 people linked to the MV Hondius cruise ship have been affected. While all passengers have been repatriated and quarantined, the World Health Organization (WHO) anticipates that additional cases may emerge based on observed symptoms.

Also Read: Hantavirus Cases Climb To 11; WHO Warns Countries Of Further Spread

In an exclusive interview with HealthandMe, Dr. Vasant, a Consultant in Infectious Diseases and Internal Medicine at Lilavati Hospital and Research Center, Mumbai, explained how the virus can spread even within indoor environments. He noted that contaminated dust and surfaces are potential sources of transmission, making proper hygiene and preventive measures crucial.

The expert also stated that the Andes strain rarely transmits person-to-person and emphasized the need for global prevention through enhanced surveillance, early detection, vector control, environmental sanitation, and public awareness, particularly amid urbanization, climate change, and ecosystem disruption.

Here are the excerpts from the interview

Q. How Long Does Hantavirus Survive?

Dr. Vasant: Hantavirus does not survive for long outside a host body and is rapidly inactivated by exposure to sunlight, detergents, and drying.

However, in enclosed indoor environments that are cool with temperatures at 4 degrees Celsius or less, poorly ventilated, and contaminated with rodent urine or feces, the virus may remain infectious for several hours or even longer.

Q. Is Hantavirus Airborne?

Dr. Vasant: Yes, the virus can be transmitted indirectly through the air. However, hantavirus does not circulate freely in the air in the same way as influenza or coronavirus during normal social interactions.

It becomes airborne when contaminated rodent urine, droppings, or nesting materials are disturbed during activities such as sweeping or cleaning. At that point, the virus can be aerosolized and inhaled by people.

Q. How Can Hantavirus Spread Indoors?

Dr. Vasant: Indoor exposure usually takes place in environments where the presence of goes unnoticed – for example, in cabins, storage rooms, warehouses, inside false ceilings, or vacant rooms.

One could be exposed to hantavirus through inhalation of contaminated dust when a room that has not been used for a while is opened or is cleaned without any protective measures.

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The reason why hantavirus exposure is alarming is that it usually takes place during normal activities, which we do without even suspecting anything dangerous.

Q. How Does the Andes Strain of Hantavirus Spread?

Dr. Vasant: The Andes hantavirus stands out because, unlike most other hantaviruses, it exhibits evidence of rare person-to-person transmission, mostly through direct and extended contact between people. As a result, this particular strain is highly interesting for scientists studying infectious diseases around the world and is extensively researched as such. It should be noted, however, that person-to-person transmission is very rare in comparison to respiratory pathogens, such as the influenza virus or SARS-CoV-2.

Read More: Why The Norovirus Outbreak On A Caribbean Cruise Ship Is Not A Cause for Panic

Q. What global strategies are needed to prevent the emergence of new viruses?

Dr. Vasant: What is required from our world in terms of the prevention of new viruses is a globally integrated strategy within the public health sector.

Surveillance systems should become more advanced on community levels, especially when there are high risks of increased contact between humans and animals because of urbanization, climate change, and ecosystem destruction.

Early detection, information exchange at the international level, vector control, environmental sanitation, and public awareness are just as significant. New infection strains cannot remain limited to just being a problem of individual countries.