Most people are aware of type 1 and type 2 diabetes, but did you know there is a type 3 diabetes as well! It is a more obscure term. Although it is not an accepted medical diagnosis, type 3 diabetes has been discussed in the literature as a possible relationship between insulin resistance in the brain and Alzheimer's disease. This link has been described to help explain how metabolic disorders impact brain health, causing cognitive decline and dementia.

What is Type 3 Diabetes?

Type 3 diabetes is more of a misnomer because it should not be confused with type 3c diabetes, which relates to pancreatic dysfunction. The term "type 3 diabetes," on the other hand, has been loosely used by some scientists to analogously propose that Alzheimer's disease is strongly implicated with insulin resistance in the brain.

This concept was conceptualized by Dr. Suzanne de la Monte and Dr. Jack Wands of Brown University in the year 2008. This hypothesis postulated that Alzheimer's disease may be called type 3 diabetes for it bears many similarities with glucose metabolism disorder type 2 diabetes. Their concept arises from the basic principle that insulin is fundamental to blood sugar regulation, but it is also the case with the brain. When brain cells become insulin-resistant, they lose access to glucose, impairing their function.

Research published in the Journal of Diabetes Science and Technology supports this hypothesis by indicating that insulin resistance can be a significant contributor to the occurrence of dementia, also referred to as Alzheimer's. The symptoms of memory loss and diminished reasoning are associated with impaired glucose metabolism in the body, especially in the cerebral tissue.

Symptoms of Type 3 Diabetes

Although type 3 diabetes is not a "medical term," its symptoms correlate well with Alzheimer's diseases that are known to reduce the ability to think in an efficient manner and bring down brain health. These signs are:

- Loss of memory, especially short-term.

- Poor judgment and judgment ability

- Failure in recognizing people or places familiar once.

- Failure in the process of reading, writing or processing numbers

- Anxiety, agitation, or mood changes.

- Disorganized thoughts or confusion

- Lack of impulse control

As the disease advances, patients may be afflicted with severe complications including an inability to swallow or control their bodily functions. In the final stages, most patients die from fatal complications such as aspiration pneumonia.

Causes of Type 3 Diabetes

This may not be well understood with regards to type 3 diabetes, or the exact link between insulin resistance and Alzheimer's disease. Some identified contributing factors include the following:

1. Insulin Resistance

Insulin acts as an important regulatory mechanism of brain functions such as memory and cognition. The reduction in insulin signaling may impair metabolism of brain cells, thus bringing about neurodegeneration.

2. Type 2 Diabetes

These diseases show a strong relationship and those individuals diagnosed with type 2 diabetes have double chances of getting Alzheimer's. In the two, the main causes can be chronic inflammation, oxidative stress, and a defect in glucose metabolism.

3. Environmental and Lifestyle Factors

Insulin resistance associated with obesity, stress, and an unhealthy diet is considered a cause that may increase the chances of Alzheimer's disease.

Researches in Frontiers in Neuroscience and The Lancet Neurology have also highlighted that drugs used for antidiabetic medication may be crucial for the prevention or at least slowing down the course of Alzheimer's.

Treatments for Type 3 Diabetes

In 2022, in a study in Pharmaceuticals, researchers studied biomarker uptake in brain regions implicated in the faulty uptake and metabolism of blood sugar in Alzheimer’s patients.

Emerging Therapies

Research into such treatments as intranasal insulin has also been promising. Intranasal delivery of insulin directly to the brain has been reported to enhance glucose uptake by brain cells, improve memory, and boost cognitive performance. While such clinical trials have been shown to be successful, additional research is needed for safety and efficacy.

Medications

For patients being aggressive or agitated, antipsychotic drugs may be prescribed; however, therapies such as cognitive rehabilitation as well as cognitive stimulation therapy serve to preserve memory and executive function.

Lifestyle Interventions

Diet, exercise, and stress management are critical in preventing and managing insulin resistance. A review in the Journal of Alzheimer's Disease also highlighted the benefits of Kirtan Kriya meditation, which can regulate genes involved in insulin and glucose metabolism, improve sleep, and reduce inflammation.

Can Type 3 Diabetes Be Prevented?

Although type 3 diabetes is not officially recognized, its connection to Alzheimer’s disease underscores the importance of proactive measures for brain health. Some prevention strategies include:

1. Healthy Diet

Consuming a balanced diet rich in antioxidants, whole grains, and healthy fats may support brain health.

2. Regular Exercise

Physical activity improves insulin sensitivity, reduces inflammation, and enhances overall metabolic health.

3. Stress Reduction

Mindfulness practices, including meditation, have been shown to lower stress levels, which can reduce the risk of cognitive decline.

The term type 3 diabetes brings out the complex relationship between metabolic disorders and brain health. Even though it is not a recognized medical condition, the concept emphasizes the crucial role of insulin in brain function and its possible contribution to Alzheimer's disease. Continued research will hopefully provide hope for therapies such as intranasal insulin and lifestyle modifications.

A healthy lifestyle is very crucial for any human being, but for cancer survivors, it's a must, as they tend to get various diseases, including cardiovascular ones. A recent study by the University of Gothenburg and St. Jude Children's Research Hospital also doubles down on this aspect. Their research reveals that a healthy lifestyle can significantly lower the risk of diseases like cardiovascular disease in childhood cancer survivors.

The study published in Nature Communications observed over 18,000 childhood cancer survivors for 30 days. The results clearly show that most of the chronic health problems among childhood cancer survivors revolve around lifestyle. Those with a habit of inactivity, obesity, smoking, and high alcohol intake are likely to catch diseases.

Aron Onerup, Pediatrician and Researcher at the University of Gothenburg and former Postdoctoral Fellow at St. Jude Children's Research Hospital in Memphis, said, "This reveals that lifestyle plays a much bigger role than previously thought. Unlike the treatments already given, the lifestyle can actually be changed."

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Another study published in JACC: CardioOncology with 2,300 cancer survivor participants finds that those who do not exercise regularly are 1.4 times more likely to contract a cardiovascular disease. The disease burden in childhood cancer survivors who do not exercise is twelve times more than that of the general population.

Aron Onerup, a Researcher within Pediatrics at Sahlgrenska Academy at the University of Gothenburg and a Specialist Physician at the Pediatric Cancer Center at Queen Silvia Children's Hospital, Sahlgrenska University Hospital, in Gothenburg, said, "This means that physical activity can make a big difference in reducing the extra risk that emerges after cancer treatment and modify the negative effects from cancer treatments. Our results provide strong scientific support for offering survivors structured support for healthy lifestyles."

Also Read: Vitamin B12 And Folate Deficiencies Behind Chronic Fatigue, New Study Finds

Why Women Are More Likely To Develop Cardiovascular Diseases?

Cardiovascular diseases are the number one reason for death among women and men, according to the Centers for Disease Control and Prevention (CDC). Statistics show that about 44% women are living with heart diseases, and it is responsible for the death of 1 in 5 women.

There are many risk factors for heart diseases, like high blood pressure, which often goes undiagnosed in women. While studies have shown that women are more likely to live longer, even with diseases, a recent report shared how women are also more likely to have cardiovascular diseases than men.

According to the study published in the American College of Cardiology, even though women often try to live healthier, if they have issues like bad food habits or high blood pressure, their risk of heart disease goes up much more than it does for men.

Vitamin B12 is vital for red blood cell formation, DNA production, and nerve function. Deficiency is more common in vegans, vegetarians, and pregnant individuals. In such cases, supplementation may be necessary to maintain adequate levels. Vitamin B9, commonly known as folate, is also very important for DNA synthesis, production of red blood cells, and cell growth.

A recent study by Osaka Metropolitan University reveals an important aspect of these two nutrients: their deficiency is directly connected with chronic fatigue. The study published in the journal Nutrient urges for a proper diet and ensuring that all necessary nutrients are present for health and energy levels.

The researchers studied over 600 healthy adults to determine whether vitamin deficiency can cause fatigue. They mainly focused on B12 and B9 because these two nutrients are crucial to maintain a natural amino acid called homocysteine in the human body. The research finds that the deficiency of these two nutrients causes an increase in homocysteine in the body, which may be connected to fatigue and low motivation.

Notably, these deficiencies can impact you differently because of your gender, as the study found that the low level of these nutrients affects men mostly with fatigue, while women feel low motivation.

Professor Hiroaki Kanouchi from Osaka Metropolitan University's Graduate School of Human Life and Ecology said, "This suggested relationship between vitamin B12, folate, and fatigue in healthy individuals may represent the first report of its kind."

Also Read: Feeling Tired And Foggy? It Could Be Vitamin B12 Deficiency

Why Does B12 Deficiency Happen?

Vitamin B12 is mainly found in animal-based foods such as meat, fish, eggs, and dairy products. People who follow vegetarian or vegan diets may need fortified foods or supplements to get enough.

Absorption is also a key factor. Vitamin B12 requires a special protein in the stomach called intrinsic factor to be absorbed properly. Certain medical conditions, medications, or aging can reduce absorption. This means that even if someone eats enough B12, their body may not absorb it efficiently.

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Why Does B9 Deficiency Happen?

Folate is naturally found in foods like leafy green vegetables, citrus fruits, lentils, beans, and whole grains, and a diet low in these can cause deficiency. Though in some cases, certain medical conditions can also be the reason for the problem.

When To See A Doctor?

If you experience ongoing fatigue, tingling sensations, or noticeable changes in memory or mood, consult a healthcare professional. A simple blood test can measure your B12 or B9 levels.

Both deficiencies are usually treatable. Treatment may include dietary changes, oral supplements, or, in more severe cases, injections. When identified early, most people recover well.

The recently released National Family Health Survey-6 (NFHS-6) indicates a growing burden of lifestyle-related diseases such as obesity, hypertension, and high blood sugar levels in the country.

According to the NFHS-6, conducted during 2023–24, there has been a significant rise in non-communicable diseases (NCDs) and lifestyle risks in India, marking a shift from infectious diseases to chronic conditions.

Speaking to HealthandMe, Dr. Parmeet Kaur, former Chief Dietitian, Department of Dietetics, AIIMS, New Delhi, said rapid urbanisation, changing food habits and declining physical activity levels are contributing to the growing burden of NCDs.

She noted that factors such as the globalization of food habits, unhealthy snacking, increased consumption of processed foods, excess salt and sugar intake, stress, poor sleep and an ageing population are all playing a role in the rise of these conditions.

"The rise in non-communicable diseases is driven not just by excess calories, but by changing food systems and lifestyles," Dr. Kaur said.

She stressed the importance of promoting traditional balanced diets, healthy snacks, regular physical activity, maintaining a healthy body weight, adequate sleep and greater reliance on home-cooked meals.

NCD Burden Rising In Younger Age Groups

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Dr. Rakesh Gupta, Senior Consultant, Internal Medicine, Indraprastha Apollo Hospital, Delhi, said the latest NFHS-6 findings point to a growing burden of metabolic risk factors across the country, including among younger age groups.

"In many cases, these conditions develop silently and remain undiagnosed for years," Dr. Gupta said.

He emphasized that tackling the problem requires shifting the focus beyond weight management alone to overall metabolic health.

How To Prevent

To prevent these conditions and identify risks at an early stage, Dr. Gupta told HealthandMe that the following measures are important:

• Regular physical activity

• Healthy eating habits

• Adequate sleep

• Stress management

• Routine health screenings

Dr. Kaur also called for strengthening nutrition education, increasing awareness about food labels and encouraging early screening for diabetes and hypertension.

"Re-emphasizing traditional and regional healthy eating patterns alongside active living will be crucial for India's future health," she added.

What Did NFHS-6 Say On NCDs?

The NFHS-6, conducted during 2023–24, covered more than 7.1 lakh women and over one lakh men across the country.

Obesity

• Obesity among women increased from 24 per cent (2019–21) to 30.7 per cent (2023–24). Urban women recorded a higher prevalence (42.8 per cent) than rural women (25.5 per cent).
• Obesity among men rose from 22.9per cent to 27.3per cent during the same period. Urban men (36.3per cent) were more affected than rural men (23 per cent).

• High blood sugar prevalence among men aged 15 years and above increased from 15.6 per cent to 20.9 per cent.
• Urban women (21.9per cent) reported higher prevalence than rural women (16.2per cent); with total prevalence among women increasing from 13.5 per cent to 17.8 per cent.

High Blood Pressure

• Among women, high blood pressure prevalence stood at 23.5 per cent in urban areas and 17.8 per cent in rural areas.
• Among men, the prevalence was 26.2 per cent in urban areas and 20.4 per cent in rural areas.

"The emerging challenges such as rising non-communicable diseases, lifestyle-related risks and the dual burden of undernutrition and rising overweight/obesity among adults highlight the need for continued focus on preventive healthcare, behavioral change and balanced nutrition strategies," the Health Ministry said.