Most people are aware of type 1 and type 2 diabetes, but did you know there is a type 3 diabetes as well! It is a more obscure term. Although it is not an accepted medical diagnosis, type 3 diabetes has been discussed in the literature as a possible relationship between insulin resistance in the brain and Alzheimer's disease. This link has been described to help explain how metabolic disorders impact brain health, causing cognitive decline and dementia.

What is Type 3 Diabetes?

Type 3 diabetes is more of a misnomer because it should not be confused with type 3c diabetes, which relates to pancreatic dysfunction. The term "type 3 diabetes," on the other hand, has been loosely used by some scientists to analogously propose that Alzheimer's disease is strongly implicated with insulin resistance in the brain.

This concept was conceptualized by Dr. Suzanne de la Monte and Dr. Jack Wands of Brown University in the year 2008. This hypothesis postulated that Alzheimer's disease may be called type 3 diabetes for it bears many similarities with glucose metabolism disorder type 2 diabetes. Their concept arises from the basic principle that insulin is fundamental to blood sugar regulation, but it is also the case with the brain. When brain cells become insulin-resistant, they lose access to glucose, impairing their function.

Research published in the Journal of Diabetes Science and Technology supports this hypothesis by indicating that insulin resistance can be a significant contributor to the occurrence of dementia, also referred to as Alzheimer's. The symptoms of memory loss and diminished reasoning are associated with impaired glucose metabolism in the body, especially in the cerebral tissue.

Symptoms of Type 3 Diabetes

Although type 3 diabetes is not a "medical term," its symptoms correlate well with Alzheimer's diseases that are known to reduce the ability to think in an efficient manner and bring down brain health. These signs are:

- Loss of memory, especially short-term.

- Poor judgment and judgment ability

- Failure in recognizing people or places familiar once.

- Failure in the process of reading, writing or processing numbers

- Anxiety, agitation, or mood changes.

- Disorganized thoughts or confusion

- Lack of impulse control

As the disease advances, patients may be afflicted with severe complications including an inability to swallow or control their bodily functions. In the final stages, most patients die from fatal complications such as aspiration pneumonia.

Causes of Type 3 Diabetes

This may not be well understood with regards to type 3 diabetes, or the exact link between insulin resistance and Alzheimer's disease. Some identified contributing factors include the following:

1. Insulin Resistance

Insulin acts as an important regulatory mechanism of brain functions such as memory and cognition. The reduction in insulin signaling may impair metabolism of brain cells, thus bringing about neurodegeneration.

2. Type 2 Diabetes

These diseases show a strong relationship and those individuals diagnosed with type 2 diabetes have double chances of getting Alzheimer's. In the two, the main causes can be chronic inflammation, oxidative stress, and a defect in glucose metabolism.

3. Environmental and Lifestyle Factors

Insulin resistance associated with obesity, stress, and an unhealthy diet is considered a cause that may increase the chances of Alzheimer's disease.

Researches in Frontiers in Neuroscience and The Lancet Neurology have also highlighted that drugs used for antidiabetic medication may be crucial for the prevention or at least slowing down the course of Alzheimer's.

Treatments for Type 3 Diabetes

In 2022, in a study in Pharmaceuticals, researchers studied biomarker uptake in brain regions implicated in the faulty uptake and metabolism of blood sugar in Alzheimer’s patients.

Emerging Therapies

Research into such treatments as intranasal insulin has also been promising. Intranasal delivery of insulin directly to the brain has been reported to enhance glucose uptake by brain cells, improve memory, and boost cognitive performance. While such clinical trials have been shown to be successful, additional research is needed for safety and efficacy.

Medications

For patients being aggressive or agitated, antipsychotic drugs may be prescribed; however, therapies such as cognitive rehabilitation as well as cognitive stimulation therapy serve to preserve memory and executive function.

Lifestyle Interventions

Diet, exercise, and stress management are critical in preventing and managing insulin resistance. A review in the Journal of Alzheimer's Disease also highlighted the benefits of Kirtan Kriya meditation, which can regulate genes involved in insulin and glucose metabolism, improve sleep, and reduce inflammation.

Can Type 3 Diabetes Be Prevented?

Although type 3 diabetes is not officially recognized, its connection to Alzheimer’s disease underscores the importance of proactive measures for brain health. Some prevention strategies include:

1. Healthy Diet

Consuming a balanced diet rich in antioxidants, whole grains, and healthy fats may support brain health.

2. Regular Exercise

Physical activity improves insulin sensitivity, reduces inflammation, and enhances overall metabolic health.

3. Stress Reduction

Mindfulness practices, including meditation, have been shown to lower stress levels, which can reduce the risk of cognitive decline.

The term type 3 diabetes brings out the complex relationship between metabolic disorders and brain health. Even though it is not a recognized medical condition, the concept emphasizes the crucial role of insulin in brain function and its possible contribution to Alzheimer's disease. Continued research will hopefully provide hope for therapies such as intranasal insulin and lifestyle modifications.

Every year, as the monsoon rolls in, hospitals and clinics across India see a familiar pattern: a sharp uptick in children and elderly patients presenting with vomiting, diarrhoea, and dehydration.

Doctors attribute this seasonal surge to a combination of contaminated water supplies, deteriorating food hygiene, and warm, humid conditions that favour the spread of viruses like rotavirus and norovirus.

Why Monsoon Fuels Gut Infections

Heavy rains and flooding routinely compromise municipal water lines, allowing sewage to mix with drinking water. Street food and produce are more prone to contamination during this period, and the humidity itself accelerates bacterial and viral growth.

Acute gastroenteritis, an inflammation of the stomach and intestines, is consistently one of the fastest rising monsoon health conditions, with rotavirus being a leading cause in children and norovirus a common culprit across age groups.

Understanding Rotavirus

Rotavirus is a highly contagious, wheel shaped virus and remains the leading cause of severe diarrhoeal illness and death in children under five worldwide. It spreads through the faecal oral route via contaminated water, food, surfaces, or close contact with an infected person, and can cause several days of intense vomiting and watery diarrhoea, putting young children at real risk of rapid dehydration.

The good news: Rotavirus vaccines, given orally in a series of doses before 8 months of age, are highly effective at preventing severe disease and are recommended as part of national immunisation programmes.

Also read: Climate Change And Progressive Urbanization Call For An Integrated Approach To Infectious Disease Surveillance

Expert Recommended Prevention Measures

1. Water safety first

Boil or filter all drinking water during the monsoon months. Avoid ice and beverages of uncertain origin, especially from street vendors.

2. Food hygiene

Steer clear of cut fruits, chaat, and other street food that has been sitting exposed. Cook food thoroughly and eat it hot. Avoid reheated leftovers stored without refrigeration.

Also read: Dengue & Guillain-Barré Syndrome: Can A Common Monsoon Illness Trigger A Serious Nerve Disorder?

3. Hand hygiene

Frequent handwashing with soap before eating, after using the toilet, and after changing diapers remains one of the single most effective, low cost interventions against faecal oral transmission.

4. Vaccination

Ensure infants complete their full rotavirus vaccine schedule on time. Vaccination substantially reduces hospitalisations and severe outcomes, even though it does not eliminate all seasonal transmission.

5. Isolate and disinfect

Because these viruses spread easily within households and childcare settings, keep infected individuals' utensils and linens separate, and disinfect surfaces regularly during an active infection.

Recognising The Warning Signs

Most cases of viral gastroenteritis are self limiting, but caregivers should watch for signs of dehydration that require urgent medical attention:

• Sunken eyes, dry mouth, or reduced tears when crying (in infants)
• Little or no urination for 6+ hours
• Lethargy or unusual drowsiness
• Persistent vomiting that prevents fluid intake
• High fever or blood in the stool

Also read: Beware! Common Mistakes New Parents Make During Their Baby’s First Monsoon

Treatment: What Actually Helps

Oral Rehydration Solution (ORS) is the cornerstone of management.

A simple homemade version consists of 1 litre of boiled and cooled water, 6 teaspoons of sugar, and half a teaspoon of salt. It can be lifesaving when commercial ORS packets are not available, though pre mixed WHO formula ORS is preferable when accessible.

Zinc supplementation (around 20 mg daily for 10 to 14 days) is recommended for children under five, as it has been shown to reduce the duration and severity of diarrhoeal episodes.

Antibiotics are not effective against viral gastroenteritis and should only be used if a bacterial cause, such as cholera, is confirmed by a doctor. Inappropriate antibiotic use can do more harm than good.

Continue feeding. For breastfed infants, continue breastfeeding throughout the illness. For older children and adults, small, frequent sips of fluids and bland, easily digestible food are better tolerated than large meals.

When to See a Doctor

Seek medical care promptly if there is persistent high fever, visible blood in the stool or vomit, signs of moderate to severe dehydration, or if symptoms do not improve within 2 to 3 days, particularly in infants, the elderly, or anyone with underlying health conditions.

By Dr. Geeta Malkan Billa, Director of Gastroenterology & Hepatology at Dr. L. H. Hiranandani Hospital

Urinary tract infections are common. A lot of people get them every year. When you have a tract infection you might feel a burning sensation when you go to the bathroom you might have to go to the bathroom a lot and your lower belly might hurt. These symptoms can get in the way of your life. You might want to try to make the pain go away on your own. Taking medicine without prescription is not a good idea.

Taking antibiotics when you do not need them can be bad for you. Urinary tract infections can become harder to cure when the bacteria get used to the medicine. This is called resistance and it is a big problem for everyone’s health. When this happens, you might get tract infections repeatedly and you might have fewer choices, for treatment. That is why it is so important to go seek medical attention at the earliest.

Causes Of UTIs

Most Urinary Tract Infections are caused by bacteria that are usually in the digestive tract and then get into the urethra. Things like not having water, not keeping yourself clean having something wrong with the urinary system or having a weak immune system can make it more likely for bacteria to grow.

If you take the medicine or stop taking it too soon the strong bacteria will live and get stronger. Over time these bacteria will not be affected by the medicines, which makes them very hard to treat. This is what happens when you have a Urinary Tract Infection that is resistant to drugs. Urinary Tract Infections, like these are very tough to deal with.

Also read: Kidney Stones In Urban India: Causes, Prevention, And Modern Treatment

Signs And Symptoms To Watch Out For:

Recognizing the early warning signs helps prevent the infection from spreading deeper into the body. Common signs of a UTI include:

• A strong, continuous urge to urinate, even immediately after emptying the bladder

• A burning or painful sensation during urination

• Passing small amounts of cloudy, dark, or unusual-smelling urine

• Visible blood in the urine, giving it a pink or reddish tint

• Pelvic pain or pressure in the lower abdomen

• Fever, chills, lower back pain, or nausea, which often signal that the infection has reached the kidneys

Also read: Prostate Cancer: NHS England's New Precision Radiotherapy Offers Hope In Just 5 Sessions

Tips For Prevention:

Preventing tract infections is always better than treating them especially now that we have a lot of antibiotic resistance. If you do simple things every day you can reduce the risk of bacteria getting into your urinary system.

Here are some things that can help:

1. Stay well hydrated: Drinking water is very important for urinary health. When you drink fluids during the day it helps wash away bacteria from the urinary system. This lowers the chance of getting an infection.

2. Prioritize good personal hygiene: Doing things to stay clean can help lower the chance of a UTI. It is best to wipe from front to back after going to the bathroom. This keeps bacteria from the stomach area from moving into the system.

3. Don’t delay urination: Going to the bathroom regularly helps stop bacteria from growing. If you hold your urine for long it can create a place where bacteria grow faster. This makes it more likely to get an infection.

4. Be cautious with intimate hygiene products: Products that have smells, like sprays or douches can hurt sensitive areas. They can also change the balance of bacteria that protect the body. This might make UTIs more likely.

5. Wear breathable fabrics: Choosing cotton underwear and clothes that're not tight helps keep the area dry. A dry and cool place is not a home, for bacteria. This lowers the chance of getting an infection.

Also read: Can You Flush Out A UTI By Drinking More Water?

Diagnosis And Proper Medical Evaluation

Accurate diagnosis is essential before starting any medication. Diagnosis start with an evaluation and a simple urine test called a urinalysis to check for bacteria white blood cells and red blood cells.

In cases a urine culture is also done. This test finds the strain of bacteria causing the infection and tests it against different medications to find out which antibiotic will work best. For people who have recurring UTIs imaging tests, like ultrasound or CT scans might be used to look at the structure of the urinary tract and find any blockages or problems that are there.

Treatment Options

Also read: Turns Out, Peeing In The Shower Could Have Unexpected Dangers

Urinary tract infections or Urinary Tract Infections can usually be treated with antibiotics. You must take all the antibiotics even if you start to feel better so that you can be sure the Urinary Tract Infection is gone and you do not get sick again.

Medicines also help with the pain and discomfort you feel when you urinate, such as burning or feeling like you must go to the bathroom all the time.

In some cases, Urinary Tract Infections may recur due to underlying conditions such as kidney stones, urinary tract blockages, an enlarged prostate or structural abnormalities of the system. When these factors are identified, treating the root cause becomes essential.

Procedures such as kidney stone removal, stent placement or corrective surgery for urinary tract abnormalities may be recommended to prevent repeated Urinary Tract Infections.

Prevention and early intervention remain the effective strategies, in managing Urinary Tract Infections. Being aware of the warning signs and getting care at the onset of symptoms and avoiding unnecessary antibiotic use can significantly reduce the risk of recurrent Urinary Tract Infections and serious complications.

With diagnosis and appropriate treatment most Urinary Tract Infections can be successfully managed, safeguarding both urinary health and overall well-being.

By Dr. Arif Akhtar, Principal Consultant - Urology, Robotics and Renal Transplant, Manipal Hospital, Gurugram

By the time we enter our 40s, the lungs begin to undergo gradual changes that can affect breathing capacity and respiratory reserve. While some changes are a normal part of ageing, persistent cough, breathlessness or recurrent chest infections should not simply be dismissed as getting older.

Experts explain why lung health deserves greater attention after 40, which everyday habits can help protect the lungs, and when screening or medical evaluation may be needed.

As we enter our 40s, what natural changes occur in our lungs, and why does lung health become more important at this stage of life?

As we age lung tissue elasticity declines and chest wall mechanics stiffen. From an oncology standpoint, age-related cellular damage and long-term exposure to cancer causing agents like tobacco increase cancer risk. Looking after lung health from young age builds the respiratory reserve needed to tolerate advanced medical or surgical interventions if required as you get older.

What everyday lifestyle habits can help keep our lungs healthy after 40?

Engage in regular aerobic conditioning exercises to maintain full breathing capacity. Reduce carcinogen exposure by avoiding active and passive tobacco smoke, and ensuring proper ventilation while cooking. using HEPA air purifiers may help to an extent. Maintain an antioxidant-rich diet to combat cellular oxidative stress.

Also read: Dream Of Becoming A Footballer Or Cricketer? Cardiologists Reveal Heart-Healthy Habits For Young Athletes

What are some early signs of declining lung health that people often dismiss as 'just ageing' but should actually get checked?

2 to 3 week cut off is applicable here. A persistent cough lasting over three weeks, progressive exertional breathlessness, recurrent chest infections, coughing up blood, or unexplained weight loss are red flags. This is for both smokers and nonsmokers. Early-stage lung cancers are frequently asymptomatic or subtle; ignoring these signs delays diagnosis. These symptoms are that of TB as well. So, that should be ruled out.

Are there any health screenings, vaccinations, or routine check-ups that adults over 40 should consider to protect their lung health?

Annual flu and once in lifetime pneumococcal vaccine prevents severe pulmonary infections. For high-risk individuals—such as heavy past or present smokers—a annual Low-Dose CT (LDCT) scan is the gold standard for early lung cancer detection, finding lesions when they are most curable. Eliminating tobacco, mitigating indoor air pollution, exercising, and maintaining balanced nutrition significantly lower cancer risk and improve overall survival outcomes.

By Dr. Sandeep Nayak, Chairman of Oncology, MACS-Renova Oncology Institute, KIMS Hospital, Bangaluru