Most people are aware of type 1 and type 2 diabetes, but did you know there is a type 3 diabetes as well! It is a more obscure term. Although it is not an accepted medical diagnosis, type 3 diabetes has been discussed in the literature as a possible relationship between insulin resistance in the brain and Alzheimer's disease. This link has been described to help explain how metabolic disorders impact brain health, causing cognitive decline and dementia.

What is Type 3 Diabetes?

Type 3 diabetes is more of a misnomer because it should not be confused with type 3c diabetes, which relates to pancreatic dysfunction. The term "type 3 diabetes," on the other hand, has been loosely used by some scientists to analogously propose that Alzheimer's disease is strongly implicated with insulin resistance in the brain.

This concept was conceptualized by Dr. Suzanne de la Monte and Dr. Jack Wands of Brown University in the year 2008. This hypothesis postulated that Alzheimer's disease may be called type 3 diabetes for it bears many similarities with glucose metabolism disorder type 2 diabetes. Their concept arises from the basic principle that insulin is fundamental to blood sugar regulation, but it is also the case with the brain. When brain cells become insulin-resistant, they lose access to glucose, impairing their function.

Research published in the Journal of Diabetes Science and Technology supports this hypothesis by indicating that insulin resistance can be a significant contributor to the occurrence of dementia, also referred to as Alzheimer's. The symptoms of memory loss and diminished reasoning are associated with impaired glucose metabolism in the body, especially in the cerebral tissue.

Symptoms of Type 3 Diabetes

Although type 3 diabetes is not a "medical term," its symptoms correlate well with Alzheimer's diseases that are known to reduce the ability to think in an efficient manner and bring down brain health. These signs are:

- Loss of memory, especially short-term.

- Poor judgment and judgment ability

- Failure in recognizing people or places familiar once.

- Failure in the process of reading, writing or processing numbers

- Anxiety, agitation, or mood changes.

- Disorganized thoughts or confusion

- Lack of impulse control

As the disease advances, patients may be afflicted with severe complications including an inability to swallow or control their bodily functions. In the final stages, most patients die from fatal complications such as aspiration pneumonia.

Causes of Type 3 Diabetes

This may not be well understood with regards to type 3 diabetes, or the exact link between insulin resistance and Alzheimer's disease. Some identified contributing factors include the following:

1. Insulin Resistance

Insulin acts as an important regulatory mechanism of brain functions such as memory and cognition. The reduction in insulin signaling may impair metabolism of brain cells, thus bringing about neurodegeneration.

2. Type 2 Diabetes

These diseases show a strong relationship and those individuals diagnosed with type 2 diabetes have double chances of getting Alzheimer's. In the two, the main causes can be chronic inflammation, oxidative stress, and a defect in glucose metabolism.

3. Environmental and Lifestyle Factors

Insulin resistance associated with obesity, stress, and an unhealthy diet is considered a cause that may increase the chances of Alzheimer's disease.

Researches in Frontiers in Neuroscience and The Lancet Neurology have also highlighted that drugs used for antidiabetic medication may be crucial for the prevention or at least slowing down the course of Alzheimer's.

Treatments for Type 3 Diabetes

In 2022, in a study in Pharmaceuticals, researchers studied biomarker uptake in brain regions implicated in the faulty uptake and metabolism of blood sugar in Alzheimer’s patients.

Emerging Therapies

Research into such treatments as intranasal insulin has also been promising. Intranasal delivery of insulin directly to the brain has been reported to enhance glucose uptake by brain cells, improve memory, and boost cognitive performance. While such clinical trials have been shown to be successful, additional research is needed for safety and efficacy.

Medications

For patients being aggressive or agitated, antipsychotic drugs may be prescribed; however, therapies such as cognitive rehabilitation as well as cognitive stimulation therapy serve to preserve memory and executive function.

Lifestyle Interventions

Diet, exercise, and stress management are critical in preventing and managing insulin resistance. A review in the Journal of Alzheimer's Disease also highlighted the benefits of Kirtan Kriya meditation, which can regulate genes involved in insulin and glucose metabolism, improve sleep, and reduce inflammation.

Can Type 3 Diabetes Be Prevented?

Although type 3 diabetes is not officially recognized, its connection to Alzheimer’s disease underscores the importance of proactive measures for brain health. Some prevention strategies include:

1. Healthy Diet

Consuming a balanced diet rich in antioxidants, whole grains, and healthy fats may support brain health.

2. Regular Exercise

Physical activity improves insulin sensitivity, reduces inflammation, and enhances overall metabolic health.

3. Stress Reduction

Mindfulness practices, including meditation, have been shown to lower stress levels, which can reduce the risk of cognitive decline.

The term type 3 diabetes brings out the complex relationship between metabolic disorders and brain health. Even though it is not a recognized medical condition, the concept emphasizes the crucial role of insulin in brain function and its possible contribution to Alzheimer's disease. Continued research will hopefully provide hope for therapies such as intranasal insulin and lifestyle modifications.

Pop singer Madonna has opened up about knee damage caused by years of dancing in high heels.

The 67-year-old superstar said running and Ashtanga yoga also added stress to her joints, leaving her with “no cartilage” in her knee, according to Interview Magazine.

“I have a bad knee now. I have no cartilage in it, thanks to dancing for so long in high heels and running on pavement and doing Ashtanga yoga,” Madonna told the magazine.

“Up until a year ago, I was jumping on trampolines and doing dance cardio and doing a lot of what a doctor would call loading on my joints. Can’t do that anymore,” she added.

Madonna said she still works out regularly while listening to her new album Confessions II, but has had to modify her fitness routine to accommodate the injury.

The Queen of Pop said she now focuses on “Peloton bikes and the Versa Climber and high-intensity circuit training. I ride my bike outside a lot. I dance.”

Madonna has previously been open about her knee injury and its impact on her career. In October 2019, she postponed a scheduled Madame X show in Brooklyn, New York.

“It's Hard for Madame to admit that she is also a human being made of flesh and blood and she must rest for the next 3 days to insure full recovery for her knee,” she wrote on Instagram.

“I am not a quitter. This hurts me more than you can imagine. It's time to take those heels and fishnets off for a few days!”

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Can High Heels Affect Knee Health?

Knee osteoarthritis (OA), a leading cause of disability, is more prevalent in women than men. Wearing high-heeled shoes has been implicated as a potential contributing factor to the higher lifetime risk of osteoarthritis in women.

Several studies have examined the relationship between high heels and knee health. Motion analysis studies have shown changes in knee alignment while walking in heels, changes that researchers have suggested may resemble patterns seen in ageing and knee osteoarthritis progression.

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A 2025 study published in The Knee by researchers from the Singapore Institute of Technology found that wearing 8-cm high-heeled shoes significantly reduced the lateral joint space width of the knee in healthy young women during standing, suggesting increased lateral knee joint stress.

The findings suggest that high heels may specifically affect the lateral compartment of the knee, potentially contributing to increased joint stress during standing.

Wearing heels for long periods can increase the load on the knees. They alter posture and walking patterns, placing additional pressure on the knee joint. Over time, this may strain the ligaments and muscles surrounding the knee, leading to pain, stiffness, and long-term damage.

In 2025, the Nicki Minaj Challenge, inspired by the rapper's 2013 song High School, gained traction on social media. The challenge, which involved balancing in high heels, reportedly resulted in injuries including fractures and, in some cases, deaths.

Most people pay little attention to their knees, legs and ankles until something goes wrong. Once pain sets in, even simple things like walking, climbing stairs, or standing for long can become a real challenge. Left unmanaged, lower limb pain gradually affects mobility, independence and quality of life.

What Is Usually Behind the Pain?

Knee pain commonly traces back to osteoarthritis, ligament injuries, cartilage damage, or years of wear. Pain in the leg can be caused by muscle injuries or conditions involving nerves and poor blood flow. The pain in the ankle is commonly caused by sprains, tendinitis, arthritis, or any injury that may have occurred earlier without complete healing.

Age, obesity, sedentary lifestyles, and constant joint injuries contribute silently to the degenerative condition of the joints.

Signs That Should Not Be Ignored

Persistent pain, swelling, stiffness, or discomfort that keeps getting worse deserves attention. If pain is disturbing your sleep, that is a clear signal to see a doctor.

Habits That Help Protect Your Joints

Walking downstairs puts considerable pressure on the knees, so limiting stair use where possible is sensible. Squatting, sitting on the floor and using Indian-style toilets place similar strain and are better avoided.

Staying active matters just as much. Regular household chores, walking, stretching and strengthening exercises, even 15 to 20 minutes a day, keep muscles strong and reduce the load on joints. Focusing on the adductor muscles around the knee is particularly effective in improving joint support.

Non-Surgical Options Worth Knowing

Surgery is not always the answer. Two non-surgical treatments carried out by a pain physician can make a meaningful difference.

Platelet-Rich Plasma therapy, or PRP, involves concentrating platelets from the patient's own blood and injecting them into the affected joint. In osteoarthritis, where cartilage gradually thins, PRP may help support regeneration and ease symptoms.

Radiofrequency Ablation, or RFA, uses a specialized needle to deliver targeted heat that interrupts the nerves responsible for sending pain signals to the brain. Relief typically lasts one to two years. The procedure is done as day care with no cuts, no stitches and no anesthesia required.

A concern many patients raise is that pain stops them from exercising or losing weight. Once pain is controlled through these treatments, walking and light activity become manageable again, which in turn supports weight loss and takes further pressure off the joints.

Custom Knee Supports

Off-the-shelf knee caps have limited effectiveness. A custom-made support, designed to redistribute body weight and reduce joint stress, works considerably better, especially in early arthritis. Many patients notice relief shortly after wearing one. They are an investment, but a worthwhile one that can reduce dependence on medication while the surrounding muscles gradually strengthen.

When to See a Doctor

If pain has lasted several weeks, is worsening, or is getting in the way of daily life, it is time to consult a specialist. Early diagnosis and the right treatment can protect joint function, restore mobility and often avoid the need for surgery.

(By Dr. Aanchal Sharma, Pain Physician, Principal Consultant and Head of Department, Department of Pain Medicine at BLK MAX Hospital, New Delhi)

Doctors in Mumbai are reporting a simultaneous rise in Covid-19, H1N1, commonly known as swine flu, and other respiratory viral infections.

As per the doctors, there is up to a 30 per cent surge in cases of COVID-19 and H1N1 as well as viral infections in the city. The doctors attributed the surge in infectious diseases to seasonal changes.

“We are currently observing a 20-30 per cent surge in Covid-19 and H1N1 (swine flu) respiratory viral infections in the city, mainly due to seasonal changes, increased humidity, and exposure to crowded places,” Dr. Aniket Mule, Consultant Internal Medicine, KIMS Hospital Thane, told HealthandMe.

Dr. Amit Saraf, Director of the Department of Internal Medicine, Jupiter Hospital, Thane, reported a rise in influenza-like illness (ILI) in the hospital.

“There is a seasonal rise in respiratory infection cases in Mumbai. Most of the people have routine viral infections, and around 10-15% of the people who are coming to OPDs have been coming positive for influenza-like illness (ILI) due to the changing weather,” Dr. Amit told HealthandMe.

Dr. Rohit Deshpande, Consultant Internal Medicine, Lilavati Hospital and Research Centre in Mumbai, told HealthandMe that the hospital is seeing a rise in swine flu cases.

“On average, 7 to 8 cases are being detected in the OPD daily. Most patients present with symptoms such as fever, cough, body ache, and fatigue”.

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What Are The Symptoms?

The experts reported that the commonly seen symptoms include:

• persistent fever,
• dry or wet cough,
• sore throat,
• fatigue,
• body ache
• mild breathlessness

Who Is More Vulnerable?

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Dr. Amit noted that people with chronic illnesses, elderly people, pregnant women and young children are still more susceptible to complications.

Dr. Rohit noted that people with diabetes and those with conditions such as COPD, asthma and heart diseases are also at higher risk of infection.

How To Prevent?

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The experts noted that most of the cases now are mild and can be handled with timely consultation, rest and supporting care.

But older people, pregnant women, children, and those with pre-existing health conditions should take extra care. Those with an ongoing fever, cough, sore throat, breathlessness, or extreme tiredness should seek immediate medical advice, Dr. Aniket said.

“Simple preventive measures like hand hygiene, use of masks in crowded places, proper hydration and timely medical consultation can help a lot in reducing the risk of complications,” he told HealthandMe.

Preventive measures for the general population include:

• Avoid self-medication
• If you experience a persistent cough or breathing difficulties, consult a doctor regarding the need for anti-viral or anti-allergy medications.
• Get vaccinated every year to boost Immunity and reduce the risk of infection.
• Avoid crowded and dusty places, redevelopment areas, or places with pigeon droppings.
• Use hand sanitizer, wash your hands frequently and thoroughly, and wear a mask in crowded or dusty environments
• Do warm saline gargles with salt or betadine twice or thrice a day
• Take steam hydration if required too
• Maintain hydration to avoid weakness, fatigue, or headache
• To boost immunity - consume green leafy vegetables & Vitamin C-rich fruits along with Vitamin D supplements