What Is Type 3 Diabetes? Insulin Resistance In The Brain That Could Trigger Alzheimer’s

Updated Dec 3, 2024 | 06:13 PM IST

SummaryDid you know type 3 diabetes, linked to insulin resistance in the brain, is associated with Alzheimer’s disease? It highlights how metabolic disorders can affect memory, cognition, and brain health.
What Is Type 3 Diabetes? Insulin Resistance In The Brain That Could Trigger Alzheimer’s

What Is Type 3 Diabetes? Insulin Resistance In The Brain That Could Trigger Alzheimer’s

Most people are aware of type 1 and type 2 diabetes, but did you know there is a type 3 diabetes as well! It is a more obscure term. Although it is not an accepted medical diagnosis, type 3 diabetes has been discussed in the literature as a possible relationship between insulin resistance in the brain and Alzheimer's disease. This link has been described to help explain how metabolic disorders impact brain health, causing cognitive decline and dementia.

What is Type 3 Diabetes?

Type 3 diabetes is more of a misnomer because it should not be confused with type 3c diabetes, which relates to pancreatic dysfunction. The term "type 3 diabetes," on the other hand, has been loosely used by some scientists to analogously propose that Alzheimer's disease is strongly implicated with insulin resistance in the brain.

This concept was conceptualized by Dr. Suzanne de la Monte and Dr. Jack Wands of Brown University in the year 2008. This hypothesis postulated that Alzheimer's disease may be called type 3 diabetes for it bears many similarities with glucose metabolism disorder type 2 diabetes. Their concept arises from the basic principle that insulin is fundamental to blood sugar regulation, but it is also the case with the brain. When brain cells become insulin-resistant, they lose access to glucose, impairing their function.

Research published in the Journal of Diabetes Science and Technology supports this hypothesis by indicating that insulin resistance can be a significant contributor to the occurrence of dementia, also referred to as Alzheimer's. The symptoms of memory loss and diminished reasoning are associated with impaired glucose metabolism in the body, especially in the cerebral tissue.

Symptoms of Type 3 Diabetes

Although type 3 diabetes is not a "medical term," its symptoms correlate well with Alzheimer's diseases that are known to reduce the ability to think in an efficient manner and bring down brain health. These signs are:

- Loss of memory, especially short-term.

- Poor judgment and judgment ability

- Failure in recognizing people or places familiar once.

- Failure in the process of reading, writing or processing numbers

- Anxiety, agitation, or mood changes.

- Disorganized thoughts or confusion

- Lack of impulse control

As the disease advances, patients may be afflicted with severe complications including an inability to swallow or control their bodily functions. In the final stages, most patients die from fatal complications such as aspiration pneumonia.

Causes of Type 3 Diabetes

This may not be well understood with regards to type 3 diabetes, or the exact link between insulin resistance and Alzheimer's disease. Some identified contributing factors include the following:

1. Insulin Resistance

Insulin acts as an important regulatory mechanism of brain functions such as memory and cognition. The reduction in insulin signaling may impair metabolism of brain cells, thus bringing about neurodegeneration.

2. Type 2 Diabetes

These diseases show a strong relationship and those individuals diagnosed with type 2 diabetes have double chances of getting Alzheimer's. In the two, the main causes can be chronic inflammation, oxidative stress, and a defect in glucose metabolism.

3. Environmental and Lifestyle Factors

Insulin resistance associated with obesity, stress, and an unhealthy diet is considered a cause that may increase the chances of Alzheimer's disease.

Researches in Frontiers in Neuroscience and The Lancet Neurology have also highlighted that drugs used for antidiabetic medication may be crucial for the prevention or at least slowing down the course of Alzheimer's.

Treatments for Type 3 Diabetes

In 2022, in a study in Pharmaceuticals, researchers studied biomarker uptake in brain regions implicated in the faulty uptake and metabolism of blood sugar in Alzheimer’s patients.

Emerging Therapies

Research into such treatments as intranasal insulin has also been promising. Intranasal delivery of insulin directly to the brain has been reported to enhance glucose uptake by brain cells, improve memory, and boost cognitive performance. While such clinical trials have been shown to be successful, additional research is needed for safety and efficacy.

Medications

For patients being aggressive or agitated, antipsychotic drugs may be prescribed; however, therapies such as cognitive rehabilitation as well as cognitive stimulation therapy serve to preserve memory and executive function.

Lifestyle Interventions

Diet, exercise, and stress management are critical in preventing and managing insulin resistance. A review in the Journal of Alzheimer's Disease also highlighted the benefits of Kirtan Kriya meditation, which can regulate genes involved in insulin and glucose metabolism, improve sleep, and reduce inflammation.

Can Type 3 Diabetes Be Prevented?

Although type 3 diabetes is not officially recognized, its connection to Alzheimer’s disease underscores the importance of proactive measures for brain health. Some prevention strategies include:

1. Healthy Diet

Consuming a balanced diet rich in antioxidants, whole grains, and healthy fats may support brain health.

2. Regular Exercise

Physical activity improves insulin sensitivity, reduces inflammation, and enhances overall metabolic health.

3. Stress Reduction

Mindfulness practices, including meditation, have been shown to lower stress levels, which can reduce the risk of cognitive decline.

The term type 3 diabetes brings out the complex relationship between metabolic disorders and brain health. Even though it is not a recognized medical condition, the concept emphasizes the crucial role of insulin in brain function and its possible contribution to Alzheimer's disease. Continued research will hopefully provide hope for therapies such as intranasal insulin and lifestyle modifications.

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India Concerned Over Measles Outbreak, Action Underway: Dr N K Arora| Exclusive

Updated Apr 30, 2026 | 06:00 PM IST

SummaryAs per official data, Bangladesh has recorded 227 child deaths since March, with the number of suspected cases reaching nearly 35,000. To counter the risk of transmission, India has strengthened surveillance in states bordering Bangladesh, like Tripura, Manipur, and Meghalaya.
India Concerned Over Measles Outbreak, Action Underway: Dr N K Arora| Exclusive

Credit: AI generated image

Amid rising cases of measles in neighboring countries, India is concerned, and steps are being taken to ward off any potential outbreaks in the nation, said Dr NK Arora, Chair of the National Verification Committee (NVC) for Measles-Rubella Elimination in India.

In an exclusive conversation with HealthandMe, the expert emphasized the growing concerns over the spread of measles, particularly following outbreaks in Myanmar and Bangladesh.

He noted that in the case of polio, India is free, and fortunately, neighbors like Nepal, Bangladesh, Bhutan, and even Myanmar are all polio-free.

“But measles is something which we are worried about,” Dr Arora said.

"We are aware of outbreaks in Myanmar, particularly among the Rohingya population, and the subsequent spread to Bangladesh, where there has been a large-scale outbreak with numerous fatalities," he added.

Measles: Strengthening India's Porous Border

As per official data, Bangladesh has recorded 227 child deaths since March in one of its worst outbreaks of measles in decades, with the number of suspected cases reaching nearly 35,000, AFP reported.

Dr Arora pointed out that the porous borders India shares with Bangladesh make the risk of cross-border transmission higher, particularly given the large movement of people between the two countries.

To counter this, the expert mentioned that India has strengthened surveillance in states bordering Bangladesh, like Tripura, Manipur, and Meghalaya, but also admitted that more efforts are needed.

Meghalaya’s state health department have called for stepping up surveillance in East Khasi Hills District. Similarly, Health officials in Tripura are also assessing the prevailing measles and rubella situation, with a focus on vaccination coverage and containment measures. The health officials have stressed to strengthen surveillance, early detection, reporting, and response mechanisms.

Also read: Measles Again On The Rise Globally: Is India At Risk?

Notably, Nepal has also reported at least four outbreaks of the deadly viral disease —one in Sarlahi and three in Baglung—since the start of 2026.

"If even one case of measles comes in, it can spread quickly due to the virus's high reproductive or transmission dynamics. A single infected child can spread the virus to up to 12 to 18 others very quickly, which is extremely worrisome," he explained.

Dr. Arora stressed the importance of identifying suspected measles cases early, which he defined as any child with fever and rash.

"While these symptoms could indicate other diseases too, it's crucial to have a sensitive definition to quickly detect measles cases.

Once a suspect with fever and rash is identified, samples are promptly sent to the lab for confirmation, and immediate alerts are issued," he told HealthandMe.

Measles: Sporadic Outbreaks In India

Dr. Arora also addressed the ongoing efforts to eliminate measles and rubella in India, which have been bolstered by targeted interventions and public awareness campaigns.

Since the beginning of the year, India is seeing sporadic outbreaks of measles. Madhya Pradesh's Gwalior reported three outbreaks, and Morena six.

Over January and February 2026, 41 children were diagnosed with measles in Tikari village in Madhya Pradesh.

However, swift action by health authorities with proactive frontline engagement and data-driven rapid response prevented an escalation into large measles outbreaks.

"Our goal is to prevent any deaths from measles, which in today's time, should be entirely avoidable," said the Chair of the NVC.

Referring to increasing child deaths due to the highly infectious disease in Bangladesh, he said: "If a child dies from measles, it indicates a significant gap in the quality of care provided."

Further, Dr. Arora explained that measles complications such as severe pneumonia, sepsis, and meningitis are of particular concern, as these can be exacerbated by weakened immunity following other illnesses, such as malaria. Therefore, he emphasized the need to improve the quality of care and ensure timely and effective treatment for affected children.

Read more: Robert F. Kennedy Jr. Denies Link To Measles Outbreak At Senate Hearing

What is Measles?

Measles is one of the world's most contagious diseases, according to the World Health Organization (WHO), and is spread through coughs and sneezes.

The vaccine-preventable disease can affect people of any age but is most common among children, and can cause complications that include brain swelling and severe respiratory problems.

Symptoms typically appear seven to 14 days after exposure and may include:

  • high fever,
  • cough,
  • runny nose,
  • red eyes,
  • rashes across the body.

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What Happens When You Log Off From Facebook And Instagram?

Updated Apr 30, 2026 | 04:01 PM IST

SummaryFacebook users over 35 showed the biggest mood improvements, while among Instagram users, the 18-to-24 group benefited most.
What Happens When You Log Off From Facebook And Instagram?

Credit: Canva

Ever tried logging off social media platforms like Facebook and Instagram? For many, checking notifications, scrolling through feeds, and engaging with content has become second nature, often leading to an unnoticed addiction.

While digital dependence can significantly impact mental health, relationships, and overall well-being, most people don’t realize how much time they’re actually spending online.

To understand its effects, researchers at Stanford University in the US asked the 36,000 study participants to log off on weekends from their Facebook and Instagram accounts. The results showed that the people who stayed off felt measurably better.

Disconnecting from social media was seen as a powerful way to regain balance and focus in the increasingly connected world.

The study split participants into groups: about 275 were paid to deactivate their accounts for six weeks, while others logged off for just one week. Both groups showed improved emotional well-being compared to those who kept scrolling, but the effect was more pronounced for Facebook users who went longer without it.

Facebook users over 35 showed the biggest mood improvements, while among Instagram users, the 18-to-24 group benefited most.

Also read: Is India Set To Implement A Social Media Ban For Children?

Social Media And Mental Health

An increasing number of studies and the community at large are convinced that social media are detrimental to our mental health and general well-being.

According to a recent YouGov poll taken in the UK in January 2026, 37 percent of adults gave a general negative review of social media's impact on their mental health, more than twice the number of people who say otherwise.

Merely 14 percent of them admitted to receiving a positive effect from social media on their mental health.

The Pew Research Center survey, conducted in 2024, discloses that 45 percent of US teenagers think social media is damaging their sleep, and 40 percent believe it is hurting their productivity, which are both key factors of mental health.

In 2023, former US Surgeon General Vivek Murthy named social media as a major threat to the mental health of teens. He also released a social media advisory about social media and mental health.

The advisory indicates that frequent social media use could be associated with changes in parts of the brain related to emotions and learning. Additionally, it can affect impulse control, social behavior, emotional regulation, and sensitivity to social punishments and rewards.

Read More: The Cost Of Social Media Addiction: Study Says It Can Give Kids Eating Disorders

In serious cases, social media can also contribute to self-harm or suicidal thoughts, especially among teens and children facing cyberbullying or trolling. Young people are particularly vulnerable to online pressures, negative comparisons, and feelings of rejection.

“Excessive social media exposure has been linked to anxiety, depression, sleep disruption, and, most importantly, difficulty with regulating attention and emotions. Algorithms intensify comparison, validation-seeking, and exposure to harmful content, which children lack the maturity to process,” Dr. Sachin Pradeep Baliga, Associate Consultant Mental Health & Behavioural Sciences, Fortis Healthcare, told HealthandMe.

Is Quitting The Only Option?

According to mental health experts, moderation and mindfully controlled usage could be the key.

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It is far more effective to come up with a plan that helps your interaction with social media platforms be healthier, such as limiting your time on social media platforms, avoiding harmful content, and pursuing real-world connections, rather than completely demonizing social media.

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AIIMS Patna Study Unravels Brain’s Critical Link In Heatstroke Deaths

Updated Apr 30, 2026 | 10:30 AM IST

SummaryThe finding can be a major step forward in the scientific basis for diagnosing heat stroke deaths through post-mortem examination, an area that has often posed challenges for autopsy surgeons in establishing a definitive cause of death, the researchers said.
AIIMS Patna Study Unravels Brain’s Critical Link In Heatstroke Deaths

Credit: iStock

A team of researchers at the All India Institute of Medical Sciences (AIIMS) in Patna has made a significant breakthrough in understanding the link between heatstroke and fatalities.

The study published in the Medico-Legal Journal identified a specific brain center and vascular injury patterns that play a crucial role in heatstroke-related deaths.

The research team discovered that the anterior hypothalamus, which serves as the brain's primary temperature-regulating center, undergoes severe structural damage during heatstroke. This damage is found to be a key factor in the fatal outcomes associated with heatstroke.

“The study establishes that the anterior hypothalamus undergoes critical structural damage during heat stroke, making it a central driver of fatal outcomes. The injury in the hypothalamus can be used as definitive evidence in the forensic diagnosis of heat-stroke deaths,” said lead author Dr Ashok Kumar Rastogi, forensic expert, in a statement.

The finding can be a major step forward in the scientific basis for diagnosing heat stroke deaths through post-mortem examination, an area that has often posed challenges for autopsy surgeons in establishing a definitive cause of death, the researchers said.

It will also help address a long-standing medico-legal issue, particularly in the context of compensation, insurance claims, and death benefits for the families of victims.

How Was The Study Conducted?

The study was conducted by the Department of Forensic Medicine at AIIMS Patna in collaboration with the Department of Anatomy and Pathology.

The study was based on detailed post-mortem investigations of individuals exposed to extreme environmental conditions in the Patna region during 2024, including temperatures reaching 48 degrees Celsius, humidity levels up to 95 per cent, and prolonged heat exposure lasting five to eight hours, the Institute said.

The results also outlined a vascular injury pattern associated with fatal heat stroke, helping build a clearer pathological profile of the condition under extreme heat exposure.

The researchers noted that the findings could strengthen forensic investigations and support more scientifically grounded death certification in suspected cases.

Heatstroke is a medical emergency with a high case fatality rate. The body’s inability to regulate internal temperature and eliminate heat gain in such conditions increases the risk of heat exhaustion and heatstroke.

Speaking to HealthandMe, Dr. Naval Vikram, Professor, Department of Medicine, at the AII India Institute of Medical Sciences (AIIMS), explained how heat stroke affects people.

“The general features of a patient with heat stroke are: first, his or her body temperature will be very high. It will not be around normal levels like 104, 105, or 106—it will be significantly elevated. Second, the person may be delirious, confused, or even in a state of unconsciousness or coma. The breathing will also be labored. These are the features of heat stroke,” Dr Vikram said.

The most vulnerable category for heat-related problems is the extremes of age—the younger children and older adults. The expert noted that younger children may not be able to express their symptoms completely. They may not be able to tell you exactly what they are feeling.

At the other end, older adults often have multiple health issues—neurological conditions, diabetes, hypertension, and kidney problems.

How Can One Prevent?

Try to avoid exposure to extreme heat as much as possible.

Adequate hydration is key.

One must cover the head and upper body, use an umbrella, stay hydrated, and take breaks in between.

If you have to work in a hot environment for a couple of hours, take a break in a cooler or temperature-controlled environment for at least half an hour before resuming, rather than continuously working in the heat.

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