Most people are aware of type 1 and type 2 diabetes, but did you know there is a type 3 diabetes as well! It is a more obscure term. Although it is not an accepted medical diagnosis, type 3 diabetes has been discussed in the literature as a possible relationship between insulin resistance in the brain and Alzheimer's disease. This link has been described to help explain how metabolic disorders impact brain health, causing cognitive decline and dementia.

What is Type 3 Diabetes?

Type 3 diabetes is more of a misnomer because it should not be confused with type 3c diabetes, which relates to pancreatic dysfunction. The term "type 3 diabetes," on the other hand, has been loosely used by some scientists to analogously propose that Alzheimer's disease is strongly implicated with insulin resistance in the brain.

This concept was conceptualized by Dr. Suzanne de la Monte and Dr. Jack Wands of Brown University in the year 2008. This hypothesis postulated that Alzheimer's disease may be called type 3 diabetes for it bears many similarities with glucose metabolism disorder type 2 diabetes. Their concept arises from the basic principle that insulin is fundamental to blood sugar regulation, but it is also the case with the brain. When brain cells become insulin-resistant, they lose access to glucose, impairing their function.

Research published in the Journal of Diabetes Science and Technology supports this hypothesis by indicating that insulin resistance can be a significant contributor to the occurrence of dementia, also referred to as Alzheimer's. The symptoms of memory loss and diminished reasoning are associated with impaired glucose metabolism in the body, especially in the cerebral tissue.

Symptoms of Type 3 Diabetes

Although type 3 diabetes is not a "medical term," its symptoms correlate well with Alzheimer's diseases that are known to reduce the ability to think in an efficient manner and bring down brain health. These signs are:

- Loss of memory, especially short-term.

- Poor judgment and judgment ability

- Failure in recognizing people or places familiar once.

- Failure in the process of reading, writing or processing numbers

- Anxiety, agitation, or mood changes.

- Disorganized thoughts or confusion

- Lack of impulse control

As the disease advances, patients may be afflicted with severe complications including an inability to swallow or control their bodily functions. In the final stages, most patients die from fatal complications such as aspiration pneumonia.

Causes of Type 3 Diabetes

This may not be well understood with regards to type 3 diabetes, or the exact link between insulin resistance and Alzheimer's disease. Some identified contributing factors include the following:

1. Insulin Resistance

Insulin acts as an important regulatory mechanism of brain functions such as memory and cognition. The reduction in insulin signaling may impair metabolism of brain cells, thus bringing about neurodegeneration.

2. Type 2 Diabetes

These diseases show a strong relationship and those individuals diagnosed with type 2 diabetes have double chances of getting Alzheimer's. In the two, the main causes can be chronic inflammation, oxidative stress, and a defect in glucose metabolism.

3. Environmental and Lifestyle Factors

Insulin resistance associated with obesity, stress, and an unhealthy diet is considered a cause that may increase the chances of Alzheimer's disease.

Researches in Frontiers in Neuroscience and The Lancet Neurology have also highlighted that drugs used for antidiabetic medication may be crucial for the prevention or at least slowing down the course of Alzheimer's.

Treatments for Type 3 Diabetes

In 2022, in a study in Pharmaceuticals, researchers studied biomarker uptake in brain regions implicated in the faulty uptake and metabolism of blood sugar in Alzheimer’s patients.

Emerging Therapies

Research into such treatments as intranasal insulin has also been promising. Intranasal delivery of insulin directly to the brain has been reported to enhance glucose uptake by brain cells, improve memory, and boost cognitive performance. While such clinical trials have been shown to be successful, additional research is needed for safety and efficacy.

Medications

For patients being aggressive or agitated, antipsychotic drugs may be prescribed; however, therapies such as cognitive rehabilitation as well as cognitive stimulation therapy serve to preserve memory and executive function.

Lifestyle Interventions

Diet, exercise, and stress management are critical in preventing and managing insulin resistance. A review in the Journal of Alzheimer's Disease also highlighted the benefits of Kirtan Kriya meditation, which can regulate genes involved in insulin and glucose metabolism, improve sleep, and reduce inflammation.

Can Type 3 Diabetes Be Prevented?

Although type 3 diabetes is not officially recognized, its connection to Alzheimer’s disease underscores the importance of proactive measures for brain health. Some prevention strategies include:

1. Healthy Diet

Consuming a balanced diet rich in antioxidants, whole grains, and healthy fats may support brain health.

2. Regular Exercise

Physical activity improves insulin sensitivity, reduces inflammation, and enhances overall metabolic health.

3. Stress Reduction

Mindfulness practices, including meditation, have been shown to lower stress levels, which can reduce the risk of cognitive decline.

The term type 3 diabetes brings out the complex relationship between metabolic disorders and brain health. Even though it is not a recognized medical condition, the concept emphasizes the crucial role of insulin in brain function and its possible contribution to Alzheimer's disease. Continued research will hopefully provide hope for therapies such as intranasal insulin and lifestyle modifications.

As summer heat intensifies both in India and globally, many people may experience unusual heart sensations such as a racing heartbeat, chest fluttering, skipped beats, or pounding sensations, even while resting.

Speaking to HealthandMe, Dr. L.K. Jha, Associate Director and Head Unit-II, Cardiology, Asian Hospital, Faridabad, said that heatwaves can significantly increase the risk of heart palpitations.

Normal healthy people may experience occasional mild palpitations due to heat exposure, which usually resolve with rest, fluids, and cooling off. However, experts warn that when palpitations are accompanied by symptoms such as chest pain, loss of consciousness, shortness of breath, extreme light-headedness, or recurring episodes while resting, they may indicate an underlying cardiac rhythm issue requiring medical attention.

“The association between heatwaves and palpitations occurs more frequently than people think,” Dr. Jha said.

Dehydration: A Key Risk Factor

The human body constantly works to maintain a stable internal temperature.

During extreme heat, blood vessels dilate to release heat through the skin, while the heart pumps faster to circulate blood and cool the body. According to Dr. Jha, this additional strain on the cardiovascular system can make the heartbeat feel stronger or irregular, especially in people sensitive to heat.

Also read: Heatwave In India: Temperatures Continuously Rising; Stay Hydrated, Says PM Modi

Dr. Jha explained that dehydration is one of the biggest contributors to heat-related palpitations.

Excessive sweating leads to the loss of water and essential electrolytes such as sodium, potassium, and magnesium, all of which are crucial for maintaining a normal heart rhythm.

“Dehydration can lower blood pressure, forcing the heart to beat faster, which may cause dizziness, shakiness, or pounding sensations,” he said.

Existing Health Conditions Can Increase Risk

Heatwaves may also worsen existing conditions such as anxiety, thyroid disorders, anemia, diabetes, and heart disease, increasing the likelihood of palpitations.

Certain medications, including blood pressure drugs, diuretics, asthma inhalers, as well as excessive consumption of caffeine or energy drinks, may further contribute to irregular heartbeats during hot weather, Dr. Jha told HealthandMe.

Sleep disturbances caused by hot nights can also trigger stress hormones in the body, potentially leading to rapid heartbeat episodes or fluttering sensations.

Also read: Climate Change Fueling Chikungunya Spread To Europe, North America, Warns Study

When To Seek Medical Help?

Dr. Jha noted that occasional mild palpitations due to heat exposure are common and often improve with rest, hydration, and cooling down.

Doctors recommend drinking fluids regularly, replenishing electrolytes through coconut water, buttermilk, lemon water, or Oral Rehydration Salts (ORS), avoiding prolonged sun exposure, and limiting caffeine and alcohol intake during heatwaves.

However, persistent or severe palpitations may indicate a more serious condition.

“If palpitations are accompanied by chest pain, shortness of breath, fainting, severe light-headedness, or repeated episodes while resting, immediate medical evaluation is necessary,” Dr. Jha warned.

He added that some heat-related palpitations may actually signal an underlying heart rhythm disorder requiring treatment.

Yellow Alert In Delhi; Heat Dome in Europe

Meanwhile, the India Meteorological Department (IMD) has issued a yellow alert for heatwave conditions in Delhi.

Heatwave conditions in the national capital are expected to continue till tomorrow, with maximum temperatures remaining between 44 and 46 degrees Celsius.

The IMD forecast also includes relief in the form of thunderstorms, dust storms, and light rainfall from May 28 evening onwards.

At the same time, European countries like France, the United Kingdom, Spain, and Germany are experiencing early heatwaves and record-breaking conditions.

The sweltering heat conditions have affected scores of people, reportedly resulting in the deaths of about seven people in France. The unusually high temperatures early in May are being triggered by a phenomenon called a “heat dome”.

As a result, southern and southwestern regions, including Portugal, Spain, and France, will experience daytime temperature highs of 38°C. The majority of France is under a moderate to high temperature warning, while Germany and the UK are witnessing maximum temperatures exceeding 30°C, the Euronews reported.

The human body thrives on essential metals, but excessive exposure can cause a variety of issues for them in the long run, and this very fact has come to light in a recent study done by a research team at the Icahn School of Medicine at Mount Sinai Hospital. The paper reveals the detrimental impact of getting exposed to toxic metals early in life.

Drs. Manish Arora, Elza Rechtman, and Megan Horton at the Icahn School of Medicine at Mount Sinai Hospital thoroughly studied the mental effects in infants after early exposure to toxic metals. The study was published in Science Advances.

The research team studied the teeth of 489 infants aged 8 to 14 years old. As teeth grow in layers, and each layer can provide data on metal exposure, the researchers measured exposure to lead, lithium, barium, copper, manganese, magnesium, tin, zinc, and strontium.

The study also monitored 395 children for symptoms relating to anxiety, depression, hyperactivity, and attention, and magnetic resonance imaging (MRI) was used to examine 191 children.

Metals like zinc, magnesium, and manganese are very important for growth and health, but overexposure to these metals in children can cause harm.

Childhood is the time for mental growth in children, but this is the same time span when they get exposed to toxic metals as well. From food to inhaling tobacco smoke or exposure through touch, there are many ways a child gets near those adversarial metals and causes harm to themselves.

The results of the study show that exposure to heavy metals mainly happens between 6 and 9 months after birth. They also claim that the excessive metal exposures during key periods of brain development can have long-lasting effects.

Also Read: How To Get Rid Of Heavy Metals In Your Body?

How To Detox From Heavy Metals?

Reducing exposure to heavy metals can be achieved through simple lifestyle and dietary changes. This includes switching to greener diets and replacing household products. High-quality fish can help minimize mercury ingestion, while cilantro, seaweed, and leafy greens are known to trap and remove toxins from the body. Aluminium-free deodorants and titanium-free makeup and toothpaste are also recommended.

For a more intensive detox, using high-quality supplements alongside drinking at least two litres of water daily can help flush heavy metals. Armistead explains that these supplements aid the body in moving heavy metals from cells to the lymphatic system, which then transports them into the bloodstream for filtration by the liver and kidneys. The toxins are ultimately excreted via urine or bowels.

Even as climate change is driving mosquitoes north, a new study warned that Europe and North America can be new hotspots for the chikungunya virus.

Alarmingly, the research indicated that 139 countries face risk, covering 21.26 per cent of global land area for chikungunya, a mosquito-borne viral disease.

Further, the findings published in the journal Frontiers in Cellular and Infection Microbiology suggest that climate-driven vector expansion has significantly broadened the geographic scope of the CHIKV threat.

Also Read: Meningitis Outbreak In Sri Lanka: 200 Reported Cases, Authorities Issued Special Guidelines

“We show that under climate change models, the virus will further expand northward into temperate regions, especially northeastern North America, central Europe, and East Asia,” said Dr Ye Xu, from Zhejiang Chinese Medical University, China.

Chikungunya is a viral illness transmitted to humans primarily through the bite of infected Aedes aegypti and Aedes albopictus mosquitoes.

How Climate Is Linked To Mosquito Behavior?

Also Read: Climate Change Fueled Rising Salmonella Drug Resistance Over Decades: The Lancet Study

As the primary vectors of chikungunya, Aedes aegypti and Aedes albopictus are highly influenced by climate conditions.

These mosquitoes thrive in warm and humid environments, with temperature playing a major role in their breeding, survival, and ability to spread the virus.

The rising temperatures can accelerate larval development, increase mosquito reproduction, and shorten the virus’s incubation period inside the mosquito, making transmission more efficient.

In the study, the researchers explained that stable temperature patterns and seasonal variations are especially important for Aedes aegypti. The species is highly sensitive to colder temperatures, with egg hatching rates dropping significantly at around 12°C. This limits how far the mosquito can spread into cooler regions.

However, climate change and warming temperatures are making previously unsuitable regions in Europe and North America more favorable for these mosquito species, raising concerns about the growing risk of chikungunya outbreaks, the team said.

“Because this mosquito can tolerate cooler conditions better than the yellow fever mosquito, warming may allow it to establish in places that used to be too cold,” said Dr Yang Wu, Guangzhou Customs Technology Center, China.

“When suitable mosquitoes become established, the chance of local chikungunya transmission increases.”

Global Chikungunya Cases

Read More: 16 Million Indians Die Due To Hypertension Every Year: AIIMS Doc

In 2025, there were 502,264 reported chikungunya cases globally, accounting for 186 deaths across 41 countries and territories, according to the Pan American Health Organization.

This disease burden is projected to escalate under climate change, which is profoundly altering the distribution patterns of infectious diseases, the researchers noted.

“The public does not need to panic, but health systems should prepare early,” warned Dr Xu.

The researchers recommended that these regions implement proactive entomological surveillance and adaptive public health infrastructure by 2040 to mitigate the threat of emerging arboviral epidemics.

Among the proposed measures, researchers include

• tracking mosquitoes,
• training healthcare workers to quickly recognise the virus,
• strengthening mosquito control,
• setting up rapid-response plans before outbreaks occur.

Chikungunya Symptoms You Should Know

Most symptoms are generally self-limiting and last for 2–3 days. The disease is characterized by

• an abrupt onset of fever,
• joint pain
• muscle pain,
• headache,
• nausea,
• fatigue
• rash.