Most people are aware of type 1 and type 2 diabetes, but did you know there is a type 3 diabetes as well! It is a more obscure term. Although it is not an accepted medical diagnosis, type 3 diabetes has been discussed in the literature as a possible relationship between insulin resistance in the brain and Alzheimer's disease. This link has been described to help explain how metabolic disorders impact brain health, causing cognitive decline and dementia.

What is Type 3 Diabetes?

Type 3 diabetes is more of a misnomer because it should not be confused with type 3c diabetes, which relates to pancreatic dysfunction. The term "type 3 diabetes," on the other hand, has been loosely used by some scientists to analogously propose that Alzheimer's disease is strongly implicated with insulin resistance in the brain.

This concept was conceptualized by Dr. Suzanne de la Monte and Dr. Jack Wands of Brown University in the year 2008. This hypothesis postulated that Alzheimer's disease may be called type 3 diabetes for it bears many similarities with glucose metabolism disorder type 2 diabetes. Their concept arises from the basic principle that insulin is fundamental to blood sugar regulation, but it is also the case with the brain. When brain cells become insulin-resistant, they lose access to glucose, impairing their function.

Research published in the Journal of Diabetes Science and Technology supports this hypothesis by indicating that insulin resistance can be a significant contributor to the occurrence of dementia, also referred to as Alzheimer's. The symptoms of memory loss and diminished reasoning are associated with impaired glucose metabolism in the body, especially in the cerebral tissue.

Symptoms of Type 3 Diabetes

Although type 3 diabetes is not a "medical term," its symptoms correlate well with Alzheimer's diseases that are known to reduce the ability to think in an efficient manner and bring down brain health. These signs are:

- Loss of memory, especially short-term.

- Poor judgment and judgment ability

- Failure in recognizing people or places familiar once.

- Failure in the process of reading, writing or processing numbers

- Anxiety, agitation, or mood changes.

- Disorganized thoughts or confusion

- Lack of impulse control

As the disease advances, patients may be afflicted with severe complications including an inability to swallow or control their bodily functions. In the final stages, most patients die from fatal complications such as aspiration pneumonia.

Causes of Type 3 Diabetes

This may not be well understood with regards to type 3 diabetes, or the exact link between insulin resistance and Alzheimer's disease. Some identified contributing factors include the following:

1. Insulin Resistance

Insulin acts as an important regulatory mechanism of brain functions such as memory and cognition. The reduction in insulin signaling may impair metabolism of brain cells, thus bringing about neurodegeneration.

2. Type 2 Diabetes

These diseases show a strong relationship and those individuals diagnosed with type 2 diabetes have double chances of getting Alzheimer's. In the two, the main causes can be chronic inflammation, oxidative stress, and a defect in glucose metabolism.

3. Environmental and Lifestyle Factors

Insulin resistance associated with obesity, stress, and an unhealthy diet is considered a cause that may increase the chances of Alzheimer's disease.

Researches in Frontiers in Neuroscience and The Lancet Neurology have also highlighted that drugs used for antidiabetic medication may be crucial for the prevention or at least slowing down the course of Alzheimer's.

Treatments for Type 3 Diabetes

In 2022, in a study in Pharmaceuticals, researchers studied biomarker uptake in brain regions implicated in the faulty uptake and metabolism of blood sugar in Alzheimer’s patients.

Emerging Therapies

Research into such treatments as intranasal insulin has also been promising. Intranasal delivery of insulin directly to the brain has been reported to enhance glucose uptake by brain cells, improve memory, and boost cognitive performance. While such clinical trials have been shown to be successful, additional research is needed for safety and efficacy.

Medications

For patients being aggressive or agitated, antipsychotic drugs may be prescribed; however, therapies such as cognitive rehabilitation as well as cognitive stimulation therapy serve to preserve memory and executive function.

Lifestyle Interventions

Diet, exercise, and stress management are critical in preventing and managing insulin resistance. A review in the Journal of Alzheimer's Disease also highlighted the benefits of Kirtan Kriya meditation, which can regulate genes involved in insulin and glucose metabolism, improve sleep, and reduce inflammation.

Can Type 3 Diabetes Be Prevented?

Although type 3 diabetes is not officially recognized, its connection to Alzheimer’s disease underscores the importance of proactive measures for brain health. Some prevention strategies include:

1. Healthy Diet

Consuming a balanced diet rich in antioxidants, whole grains, and healthy fats may support brain health.

2. Regular Exercise

Physical activity improves insulin sensitivity, reduces inflammation, and enhances overall metabolic health.

3. Stress Reduction

Mindfulness practices, including meditation, have been shown to lower stress levels, which can reduce the risk of cognitive decline.

The term type 3 diabetes brings out the complex relationship between metabolic disorders and brain health. Even though it is not a recognized medical condition, the concept emphasizes the crucial role of insulin in brain function and its possible contribution to Alzheimer's disease. Continued research will hopefully provide hope for therapies such as intranasal insulin and lifestyle modifications.

Gait, or an individual's walking pattern, is an important marker of overall health, reflecting neurological integrity, musculoskeletal function and cognitive status. Although walking may seem effortless, people often dismiss changes in their gait as signs of tiredness or ageing.

Losing balance while walking can sometimes be attributed to fatigue, dehydration or a momentary lapse in attention. However, recurrent or unexplained balance problems can also indicate an underlying neurological condition and should not be ignored, experts warned.

Dr Gaurav Batra, Principal Consultant, Neurosurgery, Yashoda Super Speciality, said individuals experiencing instability, changes in their walking pattern or more frequent tripping than usual should seek medical evaluation.

"Walking seems so natural that it is often taken for granted. However, it involves the brain, nerves, muscles, eyes and the balance system in the inner ear working in unison," he told HealthandMe.

"When there is a disorder in one of these systems, the way a person walks can be affected, which is exactly why the type of imbalance becomes an important consideration. One person may feel like they are being dragged in a particular direction," the expert added.

When Is Loss Of Balance A Neurological Warning Sign?

New, persistent or worsening balance problems warrant attention, Dr Batra said. Changes in walking patterns or deteriorating balance could sometimes indicate an underlying problem affecting the brain or spinal cord.

Certain conditions can cause pressure on the brain or spinal cord in the neck, resulting in subtle changes in walking patterns and the ability to maintain balance.

Dr Batra advised against dismissing increasingly abnormal changes in walking, particularly when they affect daily activities or occur alongside stiffness, tremors, weakness, numbness or difficulty with coordination.

Neurological Conditions That Can Affect Balance

Dr Atampreet Singh, Senior Director and Head, Institute of Neurosciences, ShardaCare - Healthcity, explained that disruptions in the systems responsible for maintaining balance can cause unsteadiness, difficulty walking in a straight line, frequent stumbling and an increased tendency to fall.

Recurrent balance problems may be associated with several neurological conditions, including:

• Parkinson's disease: Can affect movement and coordination, making walking and maintaining balance difficult.
• Cerebellar disorders: Can interfere with coordination and the ability to maintain a steady gait.
• Peripheral neuropathy: Damage to peripheral nerves can affect sensation and balance.
• Multiple sclerosis: Can disrupt communication between the brain and the rest of the body, affecting coordination and walking.

In older adults, recurrent or unexplained falls may sometimes be an early indication of an underlying neurological or sensory deficit, Dr Singh told HealthandMe.

Sudden Loss Of Balance Could Indicate A Stroke

A sudden loss of balance, particularly when accompanied by other neurological symptoms, can be a warning sign of stroke and requires immediate medical attention.

Dr Singh highlighted the following symptoms to watch for:

• Weakness or numbness on one side of the body
• Facial weakness
• Difficulty speaking
• Severe dizziness
• Visual disturbances
• A sudden, severe headache

Such symptoms require immediate medical assessment, the expert noted.

When Should You See A Doctor?

Seek medical attention if unsteadiness persists or worsens, particularly when accompanied by weakness or numbness in the arms or legs, frequent falls, severe headache, vomiting, changes in vision or speech, or loss of bladder or bowel control.

A doctor may conduct a neurological examination and recommend brain or spinal imaging, if necessary, to determine the cause.

The doctors noted that early diagnosis is important because some underlying conditions are treatable, and timely intervention may help prevent permanent neurological problems.

They advised patients to pay attention to when the imbalance began, whether it appeared suddenly or developed gradually, and whether it is accompanied by tremors, dizziness, numbness, weakness, speech changes or difficulty with coordination.

When we talk about cancer prevention, the conversation usually turns to individual choices. Whether someone smokes, what they eat, how much they exercise, or how regularly they visit a doctor. These are important considerations, but they do not tell the whole story. A person's surroundings can influence their health in ways that are not always immediately apparent. The air they breathe every day, the conditions in which they work, the food they can afford and the healthcare available to them can all have a bearing on their risk of developing cancer.

In clinical practice, cancer rarely has one identifiable cause. It develops through a combination of factors, including age, genetics, infections, lifestyle and environmental exposure. Some of these can be modified. Others are tied to circumstances that people have little control over.

The air we breathe and the work we do

Air pollution is generally discussed in the context of respiratory and cardiovascular illness. Its association with cancer, particularly lung cancer, deserves equal attention. Fine particulate matter from vehicle exhaust, industrial emissions, construction dust and waste burning can remain in the air people breathe over long periods. Indoor air quality is another concern. In homes where wood, coal or other biomass fuels are used for cooking, poor ventilation can expose families to harmful smoke over many years.

The workplace presents a different set of risks. Construction workers, miners and employees in certain manufacturing industries may regularly come into contact with substances such as asbestos, silica dust and diesel exhaust. Prolonged exposure to these carcinogens is associated with specific cancers. The risk is not simply a matter of the nature of the job, but also the conditions under which it is performed. Protective equipment, adequate ventilation and routine workplace monitoring are therefore essential, not optional safety measures.

What ends up on the plate is not always a choice

Diet is another area where personal circumstances matter. What a person eats is influenced by affordability, availability, working hours and household responsibilities. A consistently poor dietary pattern, particularly one high in processed meat and low in fibre, is associated with an increased risk of certain cancers. Excess body weight is also linked to several cancers, including colorectal, endometrial and postmenopausal breast cancer.

This does not mean that eating a particular food will cause cancer, or that avoiding one ingredient will prevent it. The concern is with patterns that develop over time, alongside other risk factors. Advising people to eat better is only useful when that advice considers what they can realistically afford and access.

Why some communities face greater challenges

The same health advice does not translate into the same opportunities for everyone. People living in congested neighbourhoods may have limited control over their exposure to pollution. Workers in informal or unregulated sectors may not have access to adequate protective equipment or occupational health services.

These circumstances can also determine how quickly someone receives a diagnosis. A persistent cough, unexplained weight loss, a breast lump or unusual bleeding may initially be dismissed. For someone who has to travel long distances, lose a day's wages or pay out of pocket for investigations, seeking medical attention is not always straightforward. By the time they reach a specialist, the disease may have progressed.

Early detection, therefore, is not just about recognising symptoms. It also depends on whether people can access a doctor, undergo the necessary investigations and complete their follow-up care.

Prevention has to go beyond individual choices

There are established ways to reduce cancer risk. Avoiding tobacco, limiting alcohol, maintaining a healthy weight and staying physically active all matter. HPV and hepatitis B vaccination can help prevent cancers associated with these infections. Screening for breast, cervical and oral cancers should be undertaken as recommended, based on age and individual risk. A persistent or unusual symptom should always be evaluated rather than left unattended.

But prevention cannot stop at the doctor's consultation room. Cleaner air, safer workplaces, better housing and affordable diagnostic services need to be part of the larger conversation.

A person's risk of cancer is shaped by more than the choices they make. It is also influenced by the conditions in which they live, work and seek care. Recognising this is important because prevention becomes meaningful only when people have a fair opportunity to act on it.

(Dr Rajesh Shinde - Director – GI (HPB–Colorectal) & Thoracic Surgical Oncology, Apollo Cancer Centre, Western Region, Apollo Hospitals)

Winter brings a significant rise in respiratory problems, particularly among people living with asthma. Increased air pollution, falling temperatures and exposure to dust and other airborne irritants can trigger inflammation in the airways, leading to symptoms such as coughing, wheezing, chest tightness and breathlessness.

While these factors can make asthma more difficult to manage, many patients also make treatment-related mistakes that can worsen their symptoms and increase the risk of an asthma attack.

One of the most common mistakes is discontinuing inhalers when symptoms improve. Asthma is a chronic inflammatory condition, and the absence of symptoms does not necessarily mean that the underlying inflammation has resolved. Controller inhalers, particularly those containing inhaled corticosteroids, help reduce airway inflammation and prevent flare-ups.

Stopping these medications without medical advice can leave patients vulnerable to sudden exacerbations, especially during periods of high pollution.

Another concern is the excessive reliance on rescue inhalers. These inhalers provide quick relief by relaxing the muscles around the airways, but they do not necessarily address the underlying inflammation. Frequent use may indicate that asthma is not adequately controlled and that the patient's treatment plan needs to be reviewed by a doctor. Patients should not increase their medication dosage or frequency without appropriate medical guidance.

Incorrect inhaler technique is another frequently overlooked problem. Patients may use their inhalers too quickly, fail to coordinate inhalation with medication release or neglect to hold their breath briefly after inhaling. These mistakes can prevent the medicine from reaching the lungs effectively. Regularly reviewing inhaler technique with a healthcare professional and using a spacer, where recommended, can significantly improve drug delivery.

Many patients also underestimate the importance of continuing their prescribed treatment during symptom-free periods. Some turn to steam inhalation, home remedies or over-the-counter cough medications instead of following their asthma management plan. Although certain supportive measures may provide comfort, they cannot replace prescribed asthma medication. Hot steam can also cause burns and should not be used as a treatment for asthma.

During winter, patients should monitor local air quality, reduce prolonged outdoor exposure when pollution levels are high, avoid tobacco smoke and other respiratory irritants, and keep their prescribed medication accessible. Wearing a well-fitting mask outdoors may help reduce exposure to particulate pollution, although it does not eliminate the risk.

Most importantly, people with asthma should have an individualised asthma action plan and attend regular follow-ups. Worsening breathlessness, difficulty speaking in full sentences or symptoms that do not respond to the prescribed reliever require urgent medical attention. With correct inhaler use, consistent treatment and timely medical review, most patients can manage their asthma more effectively even during highly polluted winter months.

(By Dr. Arunachalam M, Sr. Consultant and HOD-Pulmonology, Yatharth Super Speciality Hospital, Noida)