Most people are aware of type 1 and type 2 diabetes, but did you know there is a type 3 diabetes as well! It is a more obscure term. Although it is not an accepted medical diagnosis, type 3 diabetes has been discussed in the literature as a possible relationship between insulin resistance in the brain and Alzheimer's disease. This link has been described to help explain how metabolic disorders impact brain health, causing cognitive decline and dementia.

What is Type 3 Diabetes?

Type 3 diabetes is more of a misnomer because it should not be confused with type 3c diabetes, which relates to pancreatic dysfunction. The term "type 3 diabetes," on the other hand, has been loosely used by some scientists to analogously propose that Alzheimer's disease is strongly implicated with insulin resistance in the brain.

This concept was conceptualized by Dr. Suzanne de la Monte and Dr. Jack Wands of Brown University in the year 2008. This hypothesis postulated that Alzheimer's disease may be called type 3 diabetes for it bears many similarities with glucose metabolism disorder type 2 diabetes. Their concept arises from the basic principle that insulin is fundamental to blood sugar regulation, but it is also the case with the brain. When brain cells become insulin-resistant, they lose access to glucose, impairing their function.

Research published in the Journal of Diabetes Science and Technology supports this hypothesis by indicating that insulin resistance can be a significant contributor to the occurrence of dementia, also referred to as Alzheimer's. The symptoms of memory loss and diminished reasoning are associated with impaired glucose metabolism in the body, especially in the cerebral tissue.

Symptoms of Type 3 Diabetes

Although type 3 diabetes is not a "medical term," its symptoms correlate well with Alzheimer's diseases that are known to reduce the ability to think in an efficient manner and bring down brain health. These signs are:

- Loss of memory, especially short-term.

- Poor judgment and judgment ability

- Failure in recognizing people or places familiar once.

- Failure in the process of reading, writing or processing numbers

- Anxiety, agitation, or mood changes.

- Disorganized thoughts or confusion

- Lack of impulse control

As the disease advances, patients may be afflicted with severe complications including an inability to swallow or control their bodily functions. In the final stages, most patients die from fatal complications such as aspiration pneumonia.

Causes of Type 3 Diabetes

This may not be well understood with regards to type 3 diabetes, or the exact link between insulin resistance and Alzheimer's disease. Some identified contributing factors include the following:

1. Insulin Resistance

Insulin acts as an important regulatory mechanism of brain functions such as memory and cognition. The reduction in insulin signaling may impair metabolism of brain cells, thus bringing about neurodegeneration.

2. Type 2 Diabetes

These diseases show a strong relationship and those individuals diagnosed with type 2 diabetes have double chances of getting Alzheimer's. In the two, the main causes can be chronic inflammation, oxidative stress, and a defect in glucose metabolism.

3. Environmental and Lifestyle Factors

Insulin resistance associated with obesity, stress, and an unhealthy diet is considered a cause that may increase the chances of Alzheimer's disease.

Researches in Frontiers in Neuroscience and The Lancet Neurology have also highlighted that drugs used for antidiabetic medication may be crucial for the prevention or at least slowing down the course of Alzheimer's.

Treatments for Type 3 Diabetes

In 2022, in a study in Pharmaceuticals, researchers studied biomarker uptake in brain regions implicated in the faulty uptake and metabolism of blood sugar in Alzheimer’s patients.

Emerging Therapies

Research into such treatments as intranasal insulin has also been promising. Intranasal delivery of insulin directly to the brain has been reported to enhance glucose uptake by brain cells, improve memory, and boost cognitive performance. While such clinical trials have been shown to be successful, additional research is needed for safety and efficacy.

Medications

For patients being aggressive or agitated, antipsychotic drugs may be prescribed; however, therapies such as cognitive rehabilitation as well as cognitive stimulation therapy serve to preserve memory and executive function.

Lifestyle Interventions

Diet, exercise, and stress management are critical in preventing and managing insulin resistance. A review in the Journal of Alzheimer's Disease also highlighted the benefits of Kirtan Kriya meditation, which can regulate genes involved in insulin and glucose metabolism, improve sleep, and reduce inflammation.

Can Type 3 Diabetes Be Prevented?

Although type 3 diabetes is not officially recognized, its connection to Alzheimer’s disease underscores the importance of proactive measures for brain health. Some prevention strategies include:

1. Healthy Diet

Consuming a balanced diet rich in antioxidants, whole grains, and healthy fats may support brain health.

2. Regular Exercise

Physical activity improves insulin sensitivity, reduces inflammation, and enhances overall metabolic health.

3. Stress Reduction

Mindfulness practices, including meditation, have been shown to lower stress levels, which can reduce the risk of cognitive decline.

The term type 3 diabetes brings out the complex relationship between metabolic disorders and brain health. Even though it is not a recognized medical condition, the concept emphasizes the crucial role of insulin in brain function and its possible contribution to Alzheimer's disease. Continued research will hopefully provide hope for therapies such as intranasal insulin and lifestyle modifications.

The NHS has released a warning for people who take levothyroxine to manage thyroid conditions. With an estimated 33 million prescriptions issued every year across the UK, levothyroxine is among the most frequently prescribed medicines provided by the NHS.

Levothyroxine is mainly used to treat an underactive thyroid, a condition medically known as hypothyroidism. Depending on a patient’s needs and a GP’s assessment, the medicine is usually prescribed either as a tablet or as a liquid taken by mouth.

What Is Levothyroxine?

The NHS website explains that while most adults and children can safely take levothyroxine, there are specific situations where it may not be recommended. These restrictions are based on a person’s medical history and current health conditions.

People Who May Not Be Able to Take Levothyroxine

According to NHS guidance, levothyroxine may not be suitable if any of the following apply:

1. You have a heart condition such as angina, heart disease, or heart failure
2. You have a condition that affects your adrenal glands
3. You have previously suffered a heart attack
4. You have an overactive thyroid that produces excess thyroid hormone, known as thyrotoxicosis
5. You have diabetes
6. You have had an allergic reaction to levothyroxine or another medicine in the past
7. You have high blood pressure
8. Patients are advised to inform their GP or specialist about any of these conditions before starting treatment.

Levothyroxine: Possible Side Effects to Be Aware Of

Levothyroxine can cause a range of side effects, some of which may require urgent medical attention. Common side effects associated with the medication include:

• Flushing or excessive sweating
• Feeling restless, anxious, or overly energetic
• Difficulty sleeping
• Nausea
• Headaches
• Vomiting
• Shaking or trembling
• Diarrhoea
• Muscle cramps

The NHS notes that this is not a complete list, and other side effects may occur. Patients are advised to read the information leaflet included with their medication for full details.

Levothyroxine: When to Seek Medical Help

Although these side effects can be unpleasant, they are usually mild and do not typically require a hospital visit. If symptoms persist or become troublesome, the NHS recommends speaking to a doctor or pharmacist for advice.

However, certain symptoms should not be ignored. If you notice a fast or irregular heartbeat while taking levothyroxine, you should contact a doctor or call NHS 111 as soon as possible.

More serious symptoms require immediate action. Anyone experiencing chest pain while on levothyroxine is advised to call 999 without delay, as this could signal a medical emergency.

Disclaimer: This article is for general information only and is not a substitute for medical advice. Levothyroxine should be taken only as prescribed by a qualified healthcare professional. Do not start, stop, or change your medication without consulting your doctor. If you experience severe symptoms or a medical emergency, seek immediate medical attention or call emergency services.

Delhi, on Wednesday morning, woke up to 'very poor' air. The visibility was low and, in fact, the India Meteorological Department (IMD) issued an orange alert for dense fog between 8.30am and 10am. Visibility remained low, and as per the 24-hour average Air Quality Index, Delhi stood at 384, as confirmed by the data from the Central Pollution Control Board (CPCB). In certain areas, including Anand Vihar, AQI remained under 'severe' level, at 452.

This has resulted in cancellation of t least 148 flights and over 150 flights were delayed at the Delhi airport.

However, there may be a silver lining, in an interview with TOI, Tarun Kumar Pithode, who took charge as the new full-time member secretary of the Commission for Air Quality Management (CAQM) said that Delhi can expect "more blue-sky days over next 3-4 years".

How Does The Commission for Air Quality Management Plan To Bring Delhi's Pollution Down?

Delhi’s fight against air pollution is set to intensify over the next few years, with the CAQM outlining a multi-pronged plan aimed at delivering “more blue-sky days” for the capital. Rather than relying on emergency measures alone, the strategy focuses on long-term, structural fixes across transport, industry, energy and regional coordination.

Cutting Emissions at the Source

One of CAQM’s core priorities is reducing pollution from vehicles, which remain a major contributor to Delhi’s poor air quality. The plan pushes for faster adoption of electric vehicles, tighter checks on polluting commercial vehicles, and a stronger public transport network. Scrapping old, high-emission vehicles and discouraging diesel use through stricter enforcement are seen as key steps to curb everyday emissions, not just during winter spikes.

Cleaning Up Industry and Power Generation

Industrial pollution is another major target. CAQM has stressed a shift away from coal and other dirty fuels toward cleaner energy sources. Industries operating in and around Delhi are being pushed to adopt cleaner fuels such as natural gas, along with better emission-control technologies. Power plants in the region are also under scrutiny, with stricter norms to ensure they do not become pollution hotspots during peak winter months.

Tackling Dust and Construction Pollution

Construction dust and road dust significantly worsen Delhi’s air quality, especially during dry months. CAQM’s plan includes stricter enforcement of dust-control norms at construction sites, better mechanised road sweeping, and regular water sprinkling on major roads. Authorities are also being asked to improve urban planning to reduce exposed soil and unpaved areas that contribute to dust pollution.

Managing Seasonal Pollution and Stubble Burning

A major part of Delhi’s pollution problem comes from outside the city, particularly crop residue burning in neighboring states. CAQM has emphasized regional coordination, working with states like Punjab, Haryana and Uttar Pradesh to reduce stubble burning. This includes promoting alternative methods for crop residue management, providing financial incentives, and ensuring accountability when violations occur.

Data-Driven and Year-Round Action

Unlike earlier approaches that focused largely on winter emergencies, CAQM’s plan relies on year-round monitoring and data-driven action. Expanded air-quality monitoring, better forecasting, and early interventions are expected to prevent pollution levels from spiralling out of control. The aim is to move from reactive crisis management to consistent prevention.

A Long Road Ahead

CAQM officials acknowledge that Delhi’s pollution problem will not disappear overnight. However, with coordinated action across sectors and states, they believe the capital can see steady improvement over the next three to four years. The promise of more blue-sky days hinges not just on policy, but on strict enforcement and sustained public cooperation.

"There is a big mistake you are making when you fly and no one talks about how to prevent it," writes Dr Rema Malik, a board-certified vascular surgeon, based in Houston, Texas. On her Instagram post she talks about how our body deals with much of a serious challenge once we enter the plane and the cabin doors shut. She points out that while most of us are busy settling into our seats, our veins enter a risky environment that could raise the chance of developing a blood clot. These risks include deep vein thrombosis or DVT. She points out that this risk is not just limited to older adults, but to people with known health issues too.

What Really Happens to Your Body Mid-Flight

Dr. Malik explains that air travel creates what she calls a “three-hit combo” that puts your circulation under stress.

First is prolonged sitting. When you stay seated for hours, your calf muscles, often called your second heart, stop doing their job. These muscles help push blood back up toward the heart. Without movement, blood begins to pool in the legs instead of flowing upward.

Second comes dehydration. Cabin air is extremely dry, far drier than most natural environments. This causes your body to lose moisture faster than you realize. As dehydration sets in, your blood becomes thicker and more sluggish, which makes clot formation easier.

The third factor is cabin pressure. Lower pressure at cruising altitude causes veins to dilate or expand. This stretching weakens the tiny valves inside your veins that normally prevent blood from flowing backward. Gravity then does the rest, encouraging blood to settle in the lower limbs.

This combination is not about discomfort. It is about safety.

Read: Not Boarded Any Flight And Still Monday Feels Like A Jetlag? You Are Not Alone

Why Age Is Not the Only Risk Factor

There is a common belief that blood clots only affect the elderly or people with chronic illnesses. Dr. Malik strongly disagrees. Whether you are 25 or 65, long flights place similar stress on your circulation. Sitting still, dehydration, and pressure changes affect everyone, regardless of how fit or young they feel.

That is why she recommends preparing your body for travel just as seriously as you prepare your suitcase.

Wear the Right Protection Before You Fly

Compression socks are not just for people with medical conditions. Dr. Malik calls them non-negotiable for air travel. A compression level of 15 to 20 mmHg helps mechanically push blood upward, prevents swelling, and supports healthy circulation.

The key is timing. Put them on before you leave home, not after you board the plane, so your veins are supported from the very start.

Hydration Is a Flight Essential

Her rule is simple. Drink eight ounces of water for every hour you are in the air. This helps keep your blood from becoming too thick.

Coffee, alcohol, and wine do not count. In fact, they make dehydration worse. If you are serious about flying safely, water needs to be your main beverage.

Keep Your Calf Muscles Active

Every 30 minutes, Dr. Malik recommends doing 30 ankle pumps. Lift your toes up and down as if you are pressing a gas pedal. This simple movement activates your calf muscles and helps clear stagnant blood from your legs, even if you cannot get up and walk.