What Is Type 3 Diabetes? Insulin Resistance In The Brain That Could Trigger Alzheimer’s
Most people are aware of type 1 and type 2 diabetes, but did you know there is a type 3 diabetes as well! It is a more obscure term. Although it is not an accepted medical diagnosis, type 3 diabetes has been discussed in the literature as a possible relationship between insulin resistance in the brain and Alzheimer's disease. This link has been described to help explain how metabolic disorders impact brain health, causing cognitive decline and dementia.
Type 3 diabetes is more of a misnomer because it should not be confused with type 3c diabetes, which relates to pancreatic dysfunction. The term "type 3 diabetes," on the other hand, has been loosely used by some scientists to analogously propose that Alzheimer's disease is strongly implicated with insulin resistance in the brain.
This concept was conceptualized by Dr. Suzanne de la Monte and Dr. Jack Wands of Brown University in the year 2008. This hypothesis postulated that Alzheimer's disease may be called type 3 diabetes for it bears many similarities with glucose metabolism disorder type 2 diabetes. Their concept arises from the basic principle that insulin is fundamental to blood sugar regulation, but it is also the case with the brain. When brain cells become insulin-resistant, they lose access to glucose, impairing their function.
Research published in the Journal of Diabetes Science and Technology supports this hypothesis by indicating that insulin resistance can be a significant contributor to the occurrence of dementia, also referred to as Alzheimer's. The symptoms of memory loss and diminished reasoning are associated with impaired glucose metabolism in the body, especially in the cerebral tissue.
Although type 3 diabetes is not a "medical term," its symptoms correlate well with Alzheimer's diseases that are known to reduce the ability to think in an efficient manner and bring down brain health. These signs are:
- Loss of memory, especially short-term.
- Poor judgment and judgment ability
- Failure in recognizing people or places familiar once.
- Failure in the process of reading, writing or processing numbers
- Anxiety, agitation, or mood changes.
- Disorganized thoughts or confusion
- Lack of impulse control
As the disease advances, patients may be afflicted with severe complications including an inability to swallow or control their bodily functions. In the final stages, most patients die from fatal complications such as aspiration pneumonia.
This may not be well understood with regards to type 3 diabetes, or the exact link between insulin resistance and Alzheimer's disease. Some identified contributing factors include the following:
Insulin acts as an important regulatory mechanism of brain functions such as memory and cognition. The reduction in insulin signaling may impair metabolism of brain cells, thus bringing about neurodegeneration.
These diseases show a strong relationship and those individuals diagnosed with type 2 diabetes have double chances of getting Alzheimer's. In the two, the main causes can be chronic inflammation, oxidative stress, and a defect in glucose metabolism.
Insulin resistance associated with obesity, stress, and an unhealthy diet is considered a cause that may increase the chances of Alzheimer's disease.
Researches in Frontiers in Neuroscience and The Lancet Neurology have also highlighted that drugs used for antidiabetic medication may be crucial for the prevention or at least slowing down the course of Alzheimer's.
In 2022, in a study in Pharmaceuticals, researchers studied biomarker uptake in brain regions implicated in the faulty uptake and metabolism of blood sugar in Alzheimer’s patients.
Emerging Therapies
Research into such treatments as intranasal insulin has also been promising. Intranasal delivery of insulin directly to the brain has been reported to enhance glucose uptake by brain cells, improve memory, and boost cognitive performance. While such clinical trials have been shown to be successful, additional research is needed for safety and efficacy.
Medications
For patients being aggressive or agitated, antipsychotic drugs may be prescribed; however, therapies such as cognitive rehabilitation as well as cognitive stimulation therapy serve to preserve memory and executive function.
Lifestyle Interventions
Diet, exercise, and stress management are critical in preventing and managing insulin resistance. A review in the Journal of Alzheimer's Disease also highlighted the benefits of Kirtan Kriya meditation, which can regulate genes involved in insulin and glucose metabolism, improve sleep, and reduce inflammation.
Although type 3 diabetes is not officially recognized, its connection to Alzheimer’s disease underscores the importance of proactive measures for brain health. Some prevention strategies include:
1. Healthy Diet
Consuming a balanced diet rich in antioxidants, whole grains, and healthy fats may support brain health.
2. Regular Exercise
Physical activity improves insulin sensitivity, reduces inflammation, and enhances overall metabolic health.
3. Stress Reduction
Mindfulness practices, including meditation, have been shown to lower stress levels, which can reduce the risk of cognitive decline.
The term type 3 diabetes brings out the complex relationship between metabolic disorders and brain health. Even though it is not a recognized medical condition, the concept emphasizes the crucial role of insulin in brain function and its possible contribution to Alzheimer's disease. Continued research will hopefully provide hope for therapies such as intranasal insulin and lifestyle modifications.
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As the year draws to a close and 2026 approaches, most women find themselves juggling work deadlines, family responsibilities, and festive plans. In the middle of it all, personal health often slips to the bottom of the list. But doctors say this is exactly the time to pause and take stock of your body, especially your reproductive and hormonal health.
“Annual gynecological screening is one of the simplest ways to prevent silent illnesses, detect early changes, and understand your reproductive health better,” says Dr Tanveer Aujla, Consultant Obstetrician and Gynecologist at Motherhood Hospitals, Noida. Many common conditions show little to no symptoms in the early stages, making routine testing crucial.
Women often ignore subtle signs like fatigue, irregular periods, unexplained weight changes, or mood swings, assuming they are part of a busy lifestyle. According to Dr Aujla, this delay can be risky. “Conditions like cervical abnormalities, breast lumps, thyroid disorders, vitamin deficiencies, or hormonal imbalance often develop quietly and show symptoms only later,” she explains. A yearly check-up helps catch problems early and allows women to plan their health with confidence, especially if pregnancy is on the horizon.
One of the most important screenings is the Pap smear combined with HPV testing. The Pap test looks for abnormal cells on the cervix, while the HPV test detects high-risk viruses responsible for most cervical cancers. “Together, they form a powerful screening tool,” Dr Aujla says. Women between 25 and 65 years should undergo this test every three to five years, or as advised by their doctor.
Breast health should never be overlooked. Dr Aujla advises yearly mammograms for women above 40, along with clinical breast examinations or ultrasound scans when needed. “These screenings help identify lumps, cysts, or early tissue changes,” she notes. She also stresses the importance of monthly self-examination to check for lumps, pain, or changes like inverted nipples.
Thyroid disorders are extremely common in women and often remain undiagnosed. “A simple TSH, T3, and T4 test can explain symptoms like fatigue, mood swings, irregular periods, weight changes, or fertility issues,” says Dr Aujla. Early diagnosis can significantly improve quality of life and prevent long-term complications.
Tests like AMH offer insight into ovarian reserve and help women plan their reproductive timelines. Dr Aujla points out that this is especially important for women with PCOS, irregular cycles, or delayed family planning. Preconception screening, which includes anemia levels, vitamin D, rubella immunity, blood sugar, and hormonal panels, ensures the body is prepared for a safe pregnancy.
Women over 30 or those with a sedentary lifestyle should also get diabetes and cholesterol tests. Bone health panels checking calcium and vitamin D help prevent future osteoporosis. STI screening is equally important, as infections like chlamydia or gonorrhea can silently damage reproductive health if left untreated.
“Whether you are planning pregnancy or simply want to stay healthy, these tests offer clarity, confidence, and peace of mind,” Dr Aujla concludes. Taking time for these screenings before the year ends is a small step that can protect your health for years to come.
Credits: iStock
Santa Claus is bad for your health! This is a statement by Dr Nathan Grills, a Public Health Fellow in the Department of Epidemiology and Preventative Medicine, Monash University, Australia. Why is he saying this right ahead of Christmas?
Writing for an article in the British Medical Journal's Christmas issue (BMJ), he says, "Santa only needs to affect health by 0.1% to damage million of lives". He says it would be better if his popularity was rather used to promote healthy living.
Santa Claus's portrayal is where the concerns lie. This was not the first time someone has talked about. In fact, The Conversation in December 2024, talked about this exactly. If you look at Santa, he stands anywhere between 5'6" to 6'6" and weighs between 80Kgs to 136Kgs. He also carries a lot of weight around his belly, which, some may say, keeps him insulated as he sleighs through the snowy lands, but is sure overweight and obese. These portrayal promotes an unhealthy living.
Dr Grils also writes that Santa should rather share Rudolf's snack of carrots and celery sticks than brandy and mince pies, and swap his reindeer for a bike or a walk.
After reviewing existing literature and online sources to understand Santa Claus’s possible impact on public health, the analysis found no peer-reviewed studies directly addressing the issue. What did stand out, however, was the exceptionally high level of awareness of Santa among children. In fact, surveys of American schoolchildren showed that Santa Claus was recognized more widely than almost any other fictional character, second only to Ronald McDonald.
The doctor says that Santa is also used for selling products, which are mostly harmful, and this happens on global scale, which means, people get inspired. "Santa sells, and sometimes he sells harmful products. Like Coca-Cola, Santa has become a major export item to the developing world."
While Santa has been banned from smoking, but his images of enjoying a pipe or cigar are easily found on Christmas cards. The depiction of Santa does form a public perception, argues the doctor.
Dr Grill also notes that Santa may be promoting potential drink-driving, especially when someone follows the tradition to leave him a brandy to wish him well on his travels, while he has billion houses to visit.

Dr Grill says that he can spread diseases. If Santa sneezes or coughs around 10 times a day, all the children who sit on his lap may also end up catching the flu along with their Christmas presents.

However, it is important to note that these are views expressed by the doctor and no actual studies have been conducted on the same, Though Dr Grill does indicate for more research before calling for authorities to regulate Santa's activities. For now, Dr Grill proposes a new image for Santa, a healthier one. A slim Santa on a treadmill.
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For years, the appendix was brushed off as a useless leftover from human evolution. Many of us grew up believing that it served no real purpose and was better off removed at the first sign of trouble. But science now tells a more interesting story. This small, finger-like pouch attached to the large intestine quietly supports gut health and immunity in ways that were long overlooked.
The appendix is a narrow tube connected to the cecum, located in the lower right side of the abdomen. It usually measures between 7 and 10 cm, although its size and position can vary widely from person to person. In some people, it may be just a couple of centimeters long, while in others, it can extend much further. This variation is also why appendicitis pain can sometimes feel confusing or atypical.
The biggest shift in understanding the appendix came from research into gut bacteria. The appendix appears to act as a safe storage space for beneficial microbes. During bouts of severe diarrhea or intestinal infections, large amounts of gut bacteria are flushed out. The appendix helps reintroduce these good bacteria once the illness passes, helping the digestive system recover faster.
It also plays a role in immunity, especially during early life. The appendix contains lymphoid tissue, which exposes immune cells to substances passing through the gut. This helps the body learn how to respond to harmful invaders while tolerating harmless ones. While humans can survive perfectly well without an appendix, its presence offers subtle support to the immune and digestive systems.
Despite its benefits, the appendix is still prone to inflammation. Appendicitis is one of the most common abdominal emergencies worldwide. It usually occurs when the appendix gets blocked, often due to hardened stool, infection, or rarely, abnormal growths. Once blocked, bacteria multiply, causing swelling, pain, and infection.
The classic warning sign is pain that starts near the belly button and gradually shifts to the lower right abdomen. This may be accompanied by fever, nausea, vomiting, and loss of appetite. Ignoring these symptoms can be dangerous. If left untreated, the appendix can rupture, leading to serious and potentially life-threatening complications.
There are many myths surrounding the appendix. One of the most common is that fruit seeds or spicy food cause appendicitis. There is no evidence to support this. Another misconception is that appendicitis can settle on its own. While pain may temporarily reduce, the underlying inflammation usually worsens.
Many people also worry that removing the appendix will harm digestion or require lifelong dietary restrictions. In reality, most people return to normal eating habits and daily routines after recovery, with no long-term health issues.
Surgery remains the most reliable treatment for appendicitis. Today, minimally invasive techniques such as laparoscopic or robotic surgery are widely used. These involve small incisions, less pain, quicker recovery, and shorter hospital stays. In complicated cases, open surgery may still be required.
In selected cases of mild, uncomplicated appendicitis, antibiotics may be used initially. However, studies show that while symptoms may improve, there is a higher chance of recurrence within months. For this reason, surgery continues to be the definitive, long-term solution for most patients.
Recovery after appendix removal is usually smooth. Many patients are able to walk the same day and return home within a day or two. Light meals are recommended initially, and heavy lifting is avoided for a few weeks. Long-term lifestyle changes are rarely needed, and most people forget about the surgery entirely once healed.
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