What Is Type 3 Diabetes? Insulin Resistance In The Brain That Could Trigger Alzheimer’s
Most people are aware of type 1 and type 2 diabetes, but did you know there is a type 3 diabetes as well! It is a more obscure term. Although it is not an accepted medical diagnosis, type 3 diabetes has been discussed in the literature as a possible relationship between insulin resistance in the brain and Alzheimer's disease. This link has been described to help explain how metabolic disorders impact brain health, causing cognitive decline and dementia.
Type 3 diabetes is more of a misnomer because it should not be confused with type 3c diabetes, which relates to pancreatic dysfunction. The term "type 3 diabetes," on the other hand, has been loosely used by some scientists to analogously propose that Alzheimer's disease is strongly implicated with insulin resistance in the brain.
This concept was conceptualized by Dr. Suzanne de la Monte and Dr. Jack Wands of Brown University in the year 2008. This hypothesis postulated that Alzheimer's disease may be called type 3 diabetes for it bears many similarities with glucose metabolism disorder type 2 diabetes. Their concept arises from the basic principle that insulin is fundamental to blood sugar regulation, but it is also the case with the brain. When brain cells become insulin-resistant, they lose access to glucose, impairing their function.
Research published in the Journal of Diabetes Science and Technology supports this hypothesis by indicating that insulin resistance can be a significant contributor to the occurrence of dementia, also referred to as Alzheimer's. The symptoms of memory loss and diminished reasoning are associated with impaired glucose metabolism in the body, especially in the cerebral tissue.
Although type 3 diabetes is not a "medical term," its symptoms correlate well with Alzheimer's diseases that are known to reduce the ability to think in an efficient manner and bring down brain health. These signs are:
- Loss of memory, especially short-term.
- Poor judgment and judgment ability
- Failure in recognizing people or places familiar once.
- Failure in the process of reading, writing or processing numbers
- Anxiety, agitation, or mood changes.
- Disorganized thoughts or confusion
- Lack of impulse control
As the disease advances, patients may be afflicted with severe complications including an inability to swallow or control their bodily functions. In the final stages, most patients die from fatal complications such as aspiration pneumonia.
This may not be well understood with regards to type 3 diabetes, or the exact link between insulin resistance and Alzheimer's disease. Some identified contributing factors include the following:
Insulin acts as an important regulatory mechanism of brain functions such as memory and cognition. The reduction in insulin signaling may impair metabolism of brain cells, thus bringing about neurodegeneration.
These diseases show a strong relationship and those individuals diagnosed with type 2 diabetes have double chances of getting Alzheimer's. In the two, the main causes can be chronic inflammation, oxidative stress, and a defect in glucose metabolism.
Insulin resistance associated with obesity, stress, and an unhealthy diet is considered a cause that may increase the chances of Alzheimer's disease.
Researches in Frontiers in Neuroscience and The Lancet Neurology have also highlighted that drugs used for antidiabetic medication may be crucial for the prevention or at least slowing down the course of Alzheimer's.
In 2022, in a study in Pharmaceuticals, researchers studied biomarker uptake in brain regions implicated in the faulty uptake and metabolism of blood sugar in Alzheimer’s patients.
Emerging Therapies
Research into such treatments as intranasal insulin has also been promising. Intranasal delivery of insulin directly to the brain has been reported to enhance glucose uptake by brain cells, improve memory, and boost cognitive performance. While such clinical trials have been shown to be successful, additional research is needed for safety and efficacy.
Medications
For patients being aggressive or agitated, antipsychotic drugs may be prescribed; however, therapies such as cognitive rehabilitation as well as cognitive stimulation therapy serve to preserve memory and executive function.
Lifestyle Interventions
Diet, exercise, and stress management are critical in preventing and managing insulin resistance. A review in the Journal of Alzheimer's Disease also highlighted the benefits of Kirtan Kriya meditation, which can regulate genes involved in insulin and glucose metabolism, improve sleep, and reduce inflammation.
Although type 3 diabetes is not officially recognized, its connection to Alzheimer’s disease underscores the importance of proactive measures for brain health. Some prevention strategies include:
1. Healthy Diet
Consuming a balanced diet rich in antioxidants, whole grains, and healthy fats may support brain health.
2. Regular Exercise
Physical activity improves insulin sensitivity, reduces inflammation, and enhances overall metabolic health.
3. Stress Reduction
Mindfulness practices, including meditation, have been shown to lower stress levels, which can reduce the risk of cognitive decline.
The term type 3 diabetes brings out the complex relationship between metabolic disorders and brain health. Even though it is not a recognized medical condition, the concept emphasizes the crucial role of insulin in brain function and its possible contribution to Alzheimer's disease. Continued research will hopefully provide hope for therapies such as intranasal insulin and lifestyle modifications.
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It's just July, and Mumbai’s monsoon has been swinging from tumultuous to alarmingly parched. When the climate shifts with such volatility, it’s bound to have an impact on your overall health.
From dehydration risk to chances of gastrointestinal infections, here’s how rapidly changing weather can take a toll on your mental health.
HealthandMe spoke to Dr. Abizer Manked, Consultant Physician and Diabetologist at Saifee Hospital, Mumbai. One of the health impacts extreme weather has is on the respiratory system. Due to the increase of irritants and allergens, several respiratory issues can be triggered.
Dr Manked says, “The temperature and humidity can irritate our airways. This can trigger asthma, bronchitis, and allergies. It can also trigger coughing, giving us throat infections, and making it harder to breathe. This is especially true for people who already face breathing problems.”
The expert says that allergy episodes increase significantly during the monsoon, especially when the rain is inconsistent. An increase in humidity paves the way for mould and fungi growth, which can make allergies worse.
When temperatures and humidity change rapidly, our immune response can take a hit. It can lead to frequent episodes of common cold, cough, and other flu-like symptoms.
“When the weather changes quickly, it can also make us more likely to get infections like the common cold and flu. The weather itself does not make us sick. The sudden change can affect our body’s ability to fight off infections. When we are indoors with a lot of people during the rain, viruses spread easily,” Dr Manked explains.
Also read: Delhi's Poor AQI, Monsoon Conditions Put Children's Lungs at Risk: Ways to Keep Kids Safe
When a heavy rain episode is followed by hot and humid weather, it can lead to increased risk of heat-related illnesses.
Dr Manked says, “The humidity makes it hard for our bodies to cool down. This can make us tired, give us headaches, and leave us dehydrated more frequently. It can even lead to heat exhaustion. This especially holds true for people who work outside or spend a lot of time in the sun.”
In the monsoon, Mumbai sees the highest number of cases of viral and parasite infections like dengue and malaria.
Flooding and waterlogging create breeding hotspots for mosquitoes, which can lead to more chances of infections. Poor hygiene and maintenance of surroundings further increase the risk.
Staying in damp clothes and shoes for long periods increases the risk of contracting fungal infections. The expert says it’s crucial to keep one’s clothes dry to avoid the riks of skin infections.
Also read: Allergic Rhinitis Affects 1 In 10 Indian Adults. Here's Why Monsoon Makes It Worse, And What Helps
Simple precautions can go a long way in reducing health risks during an irregular monsoon:
Children, older adults, and people with asthma, diabetes, high blood pressure, obesity, and other chronic illnesses are more likely to face these health effects during the monsoon. It is, therefore, crucial to take extra precautions and care for those with a weakened immune system.
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When you hear the term plastic surgery, what comes to mind first? For many people, it's cosmetic enhancements such as facelifts, rhinoplasty, or body contouring. However, experts say this is one of the biggest misconceptions about the specialty.
Marking World Plastic Surgery Day on July 15, specialists highlighted that plastic surgery is far more than improving appearance. While cosmetic surgery focuses on enhancing aesthetics, reconstructive plastic surgery is dedicated to restoring form and function after injuries, burns, cancer, or congenital conditions.
Originally launched as National Plastic Surgery Day by the Association of Plastic Surgeons of India (APSI) in 2011, the observance was adopted globally by international plastic surgery societies in 2021.
The theme for World Plastic Surgery Day 2026 is "Changing Lives with Plastic and Reconstructive Surgery."
Speaking to HealthandMe, Dr. Deepak K. L. Gowda, Senior Consultant – Aesthetics, Plastic Surgery & Reconstructive Surgery at SPARSH Hospital, said plastic surgery is a broad medical specialty, while cosmetic surgery is only one of its subspecialties.
Cosmetic surgery is performed to improve the appearance of otherwise healthy and functional body structures. Reconstructive plastic surgery, on the other hand, aims to restore appearance and function following injury, disease, cancer surgery, burns, or congenital defects.
According to Dr. Gowda, reconstructive procedures account for more than 75% of plastic surgery practice, while cosmetic procedures make up a comparatively smaller proportion. However, the growing popularity of aesthetic treatments has led many people to wrongly assume that plastic surgery is only about beauty enhancement.
Cosmetic surgery is designed to enhance physical appearance in individuals whose body structures function normally. Some of the most commonly performed procedures include: breast augmentation, rhinoplasty (nose reshaping), facelifts
and dermal fillers and more.
Reconstructive plastic surgery helps restore both appearance and function after illness, injury, or trauma. Common procedures include:
Dr. Chintan Gujarati, Cosmetic and Plastic Surgeon at Ruby Hall Clinic, told HealthandMe that cosmetic procedures can enhance appearance and boost confidence, but they should always be approached with careful planning and informed decision-making.
He recommended asking these seven questions before undergoing any cosmetic procedure:
1. Is the procedure right for me?
Discuss whether the treatment is suitable for your health, goals, and individual needs.
2. Is my surgeon qualified?
Ensure the procedure is performed by a board-certified plastic surgeon or a trained specialist with relevant experience.
3. What are the risks?
Understand possible complications, including infection, scarring, or the need for additional treatment.
4. What results can I realistically expect?
Cosmetic procedures can improve appearance, but they cannot guarantee perfection.
5. What is the recovery process?
Ask about downtime, pain management, activity restrictions, and when you can safely return to your routine.
6. What will the procedure cost?
Request a detailed breakdown covering consultation fees, hospital charges, medications, and follow-up visits to avoid unexpected expenses.
7. What if I am unhappy with the results?
Discuss revision policies and available corrective options before making a decision.
Making an Informed Decision
Experts emphasized that choosing to undergo a cosmetic procedure is a personal decision that should be based on realistic expectations, qualified medical advice, and a clear understanding of the benefits, risks, recovery process, and overall costs.
They also stress that plastic surgery extends well beyond aesthetics, with reconstructive surgery continuing to play a vital role in restoring both function and quality of life for patients affected by injury, disease, or congenital conditions.
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A new study has found that muscle health may be just as important as body weight in determining a person's risk of developing type 2 diabetes, highlighting the need to look beyond the number on the scale.
The research, led by Curtin University in Australia found that people with both excess body fat and low muscle mass faced a significantly greater risk of developing type 2 diabetes than those who had obesity alone. The findings said that building and preserving muscle mass could become key in diabetes prevention.
The researchers studied data from thousands of adults to examine how body composition shapes type 2 diabetes risk. Participants were grouped based on levels of body fat and muscle mass, allowing scientists to compare how different combinations affected the chances of developing the disease.
Individuals with both high body fat and poor muscle health were more prone to type 2 diabetes compared to people who were obese but maintained healthier muscle mass.
According to the researchers, the findings confirm that muscle tissue plays a vital role in regulating blood sugar because it is one of the body's primary sites for glucose storage and use.
"Most people know carrying excess weight can increase the risk of type 2 diabetes, but our findings show muscle health is also an important piece of the puzzle," said lead researcher Mr. Guan. "People with both excess body fat and low muscle mass had a substantially higher risk of developing type 2 diabetes than those with obesity alone."
He added, "This suggests we need to look beyond the number on the scales when assessing diabetes risk, as maintaining muscle strength and muscle mass may be just as important as managing body weight."
Also read: Wegovy More Likely To Cause Rare Blindness Than Ozempic And Other Similar Drugs, Recent Study Finds
The study also sheds light on sarcopenic obesity, a condition characterized by excess body fat combined with reduced muscle mass or muscle function. Researchers say this condition is often overlooked because many people appear to have only obesity, while declining muscle health remains undetected.
Experts believe the findings indicate that rather than relying solely on body mass index (BMI), experts must assess muscle mass and strength when identifying patients at high risk for diabetes. This can help prevent the disease early.
The research also supports current public health recommendations that say resistance training alongside aerobic exercise is crucial.
Strength training helps preserve and build muscle mass while improving insulin sensitivity, making it an important component of diabetes prevention. Combined with adequate protein intake and healthy weight management, maintaining muscle health may significantly reduce long-term metabolic risk.
Type 2 diabetes is a metabolic disorder in which the body fails to utilize insulin. Frequently associated with obesity, a diet lacking in nutritious foods, and physical inactivity can lead to this diagnosis, It affects hundreds of millions of people worldwide and continues to rise alongside increasing rates of obesity and physical inactivity.
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