Most people are aware of type 1 and type 2 diabetes, but did you know there is a type 3 diabetes as well! It is a more obscure term. Although it is not an accepted medical diagnosis, type 3 diabetes has been discussed in the literature as a possible relationship between insulin resistance in the brain and Alzheimer's disease. This link has been described to help explain how metabolic disorders impact brain health, causing cognitive decline and dementia.

What is Type 3 Diabetes?

Type 3 diabetes is more of a misnomer because it should not be confused with type 3c diabetes, which relates to pancreatic dysfunction. The term "type 3 diabetes," on the other hand, has been loosely used by some scientists to analogously propose that Alzheimer's disease is strongly implicated with insulin resistance in the brain.

This concept was conceptualized by Dr. Suzanne de la Monte and Dr. Jack Wands of Brown University in the year 2008. This hypothesis postulated that Alzheimer's disease may be called type 3 diabetes for it bears many similarities with glucose metabolism disorder type 2 diabetes. Their concept arises from the basic principle that insulin is fundamental to blood sugar regulation, but it is also the case with the brain. When brain cells become insulin-resistant, they lose access to glucose, impairing their function.

Research published in the Journal of Diabetes Science and Technology supports this hypothesis by indicating that insulin resistance can be a significant contributor to the occurrence of dementia, also referred to as Alzheimer's. The symptoms of memory loss and diminished reasoning are associated with impaired glucose metabolism in the body, especially in the cerebral tissue.

Symptoms of Type 3 Diabetes

Although type 3 diabetes is not a "medical term," its symptoms correlate well with Alzheimer's diseases that are known to reduce the ability to think in an efficient manner and bring down brain health. These signs are:

- Loss of memory, especially short-term.

- Poor judgment and judgment ability

- Failure in recognizing people or places familiar once.

- Failure in the process of reading, writing or processing numbers

- Anxiety, agitation, or mood changes.

- Disorganized thoughts or confusion

- Lack of impulse control

As the disease advances, patients may be afflicted with severe complications including an inability to swallow or control their bodily functions. In the final stages, most patients die from fatal complications such as aspiration pneumonia.

Causes of Type 3 Diabetes

This may not be well understood with regards to type 3 diabetes, or the exact link between insulin resistance and Alzheimer's disease. Some identified contributing factors include the following:

1. Insulin Resistance

Insulin acts as an important regulatory mechanism of brain functions such as memory and cognition. The reduction in insulin signaling may impair metabolism of brain cells, thus bringing about neurodegeneration.

2. Type 2 Diabetes

These diseases show a strong relationship and those individuals diagnosed with type 2 diabetes have double chances of getting Alzheimer's. In the two, the main causes can be chronic inflammation, oxidative stress, and a defect in glucose metabolism.

3. Environmental and Lifestyle Factors

Insulin resistance associated with obesity, stress, and an unhealthy diet is considered a cause that may increase the chances of Alzheimer's disease.

Researches in Frontiers in Neuroscience and The Lancet Neurology have also highlighted that drugs used for antidiabetic medication may be crucial for the prevention or at least slowing down the course of Alzheimer's.

Treatments for Type 3 Diabetes

In 2022, in a study in Pharmaceuticals, researchers studied biomarker uptake in brain regions implicated in the faulty uptake and metabolism of blood sugar in Alzheimer’s patients.

Emerging Therapies

Research into such treatments as intranasal insulin has also been promising. Intranasal delivery of insulin directly to the brain has been reported to enhance glucose uptake by brain cells, improve memory, and boost cognitive performance. While such clinical trials have been shown to be successful, additional research is needed for safety and efficacy.

Medications

For patients being aggressive or agitated, antipsychotic drugs may be prescribed; however, therapies such as cognitive rehabilitation as well as cognitive stimulation therapy serve to preserve memory and executive function.

Lifestyle Interventions

Diet, exercise, and stress management are critical in preventing and managing insulin resistance. A review in the Journal of Alzheimer's Disease also highlighted the benefits of Kirtan Kriya meditation, which can regulate genes involved in insulin and glucose metabolism, improve sleep, and reduce inflammation.

Can Type 3 Diabetes Be Prevented?

Although type 3 diabetes is not officially recognized, its connection to Alzheimer’s disease underscores the importance of proactive measures for brain health. Some prevention strategies include:

1. Healthy Diet

Consuming a balanced diet rich in antioxidants, whole grains, and healthy fats may support brain health.

2. Regular Exercise

Physical activity improves insulin sensitivity, reduces inflammation, and enhances overall metabolic health.

3. Stress Reduction

Mindfulness practices, including meditation, have been shown to lower stress levels, which can reduce the risk of cognitive decline.

The term type 3 diabetes brings out the complex relationship between metabolic disorders and brain health. Even though it is not a recognized medical condition, the concept emphasizes the crucial role of insulin in brain function and its possible contribution to Alzheimer's disease. Continued research will hopefully provide hope for therapies such as intranasal insulin and lifestyle modifications.

A fall at home might look small, but for women older than 65, a broken hip can be a big and serious health problem. In real medical terms, this condition has a 20 to 30 percent chance of being deadly within the first year.

As people get older, their bones get weaker because of osteoporosis, which makes them more likely to break even from small falls. However, the bigger problem starts once the injury happens.

According to World Health organization (WHO), around 60 per cent of people living with osteoarthritis are women, yet awareness remains limited until symptoms begin to interfere with mobility and daily function.

Loss Of Muscles

Reports show that 70 per cent of women will get arthritis and osteoporosis. Most of them had no idea it was coming. HealthandMe spoke to experts to understand the reasons behind the trend.

Dr Gurdeep Avinash Ratra, Consultant - Orthopedics and Joint Replacement, Manipal Hospitals, Gurugram said that the development of these disorders is gradual and closely tied to physiological changes.

“After the age of 30, there is a steady decline in muscle mass, accompanied by a more rapid reduction in strength and power. With menopause, the significant fall in estrogen levels removes natural protection for bone density and joint health. Over time, this leads to increased bone fragility, reduced muscular support, and stress on joints, thereby elevating the risk of fractures and chronic joint conditions,” Ratra told HealthandMe.

Health Coach Prashant Desai in a post on social media platform X, noted that after the age of 30:

• muscle mass starts declining by 1 per cent every year.
• muscle strength declines three times faster.
• muscle power declines eight times faster.

Treatment

Experts said a hip fracture needs to be treated right away as a serious medical problem that requires care from many different medical specialists, not just a doctor who focuses on bones.

Dr Rajesh Kumar Verma, Director – Orthopedics & Joint Replacement, Max Super Speciality Hospital, Vaishali explained that limited movement can cause blood clots, chest infections, pressure sores, and loss of muscle quickly. Many patients also face a quick drop in their ability to take care of themselves, which can impact both their body and mind.

Also read: Suffering From Mid-back Pain? Doctors Say It May Be Spinal TB

“Delayed treatment further increases risk. Early surgery and prompt recovery treatment help increase the chances of surviving and recovering better,” Verma told HealthandMe.

How to Prevent

• Maintaining a healthy waist circumference as an early indicator of metabolic health.
• Engaging in regular strength training to preserve bone density and muscle mass.
• Ensuring adequate protein intake to support muscle maintenance.
• Incorporating sufficient calcium and Vitamin D into the diet.
• Remaining physically active, with exercise beyond low impact activities alone.
• Get medical help right away if you fall or think you might have a broken bone.
• Have surgery as soon as your doctor suggests it, because it can help you recover better.
• Begin physiotherapy as soon as possible after the surgery to help restore movement and avoid any serious issues.
• Make sure to eat well, paying special attention to getting enough protein, calcium, and vitamin D.
• Check for fall risks at home by looking at things like lighting, floor surfaces, and handrails.

What to avoid

• Do not wait to go to the hospital, even if the hip fracture pain feels okay.
• Avoid staying in bed for long because a hip fracture can lead to infections, pressure sores, and blood clots.
• Do not skip osteoporosis treatment for hip fractures because it is very important to stop broken bones from happening again.
• Avoid skipping follow-ups or rehabilitation sessions for hip fractures after the surgery.

World Health Day serves as a reminder that regular preventive health check-ups stand as mandatory health assessments that all women need to undergo for their long-term health.

Many serious conditions, such as breast cancer, cervical cancer, thyroid disorders, diabetes, and cardiovascular diseases, often remain silent in their early stages, making regular screening the most effective way to detect them early, when treatment is simpler, less invasive, and more successful.

How Preventive Healthcare Can Help Women

Preventive healthcare enables women to take a proactive role in managing their health rather than responding to illness at an advanced stage. Early detection not only improves clinical outcomes but also effectively decreases treatment difficulties, emotional distress and financial costs while providing superior long-term life quality.

This also helps in identifying risk factors early, allowing timely lifestyle modifications that can prevent disease onset altogether.

Despite this, women often deprioritize their own health due to the multiple roles they juggle, balancing careers, caregiving responsibilities, and family needs. There is also a continued hesitation around discussing reproductive and intimate health concerns, along with a lack of awareness, fear of diagnosis, and social stigma, all of which contribute to delays in seeking timely care.

In many cases, women assume that the absence of symptoms indicates good health, which is a common but risky misconception.

Importance Of Routine Screening

Routine screenings such as Pap smears for cervical health, regular breast examinations, mammography where indicated, thyroid function tests, and basic metabolic screenings like blood sugar and cholesterol levels are critical tools in preventive care.

Periodic health check-ups also provide an opportunity for counselling on nutrition, mental well-being, hormonal health, and lifestyle management, areas that are often overlooked but equally important.

World Health Day serves as a reminder to shift from a reactive to a preventive approach. Prioritizing regular health check-ups, normalizing conversations around women’s health, and encouraging a culture of self-care can significantly improve outcomes. Investing in preventive healthcare is one of the most powerful steps women can take towards leading healthier, longer, and more empowered lives.

Aging is a significant factor in memory loss and cognitive decline. Now, a team of US researchers has pinpointed a single protein that drives these changes in the brains of the elderly.

In aging mice, higher levels of protein FTL1 weakened connections between brain cells, leading to memory decline.

But when FTL1 was reduced, the brain began to recover. It also rebuilt lost connections and restored memory performance, according to the study, published in Nature Aging.

Also Read: Eye Drops: US FDA Recalls Over 3 Million Products Over Safety Concerns

"It is truly a reversal of impairments," said Saul Villeda, Associate Director at the University of California - San Francisco's Bakar Aging Research Institute and senior author of the paper. "It's much more than merely delaying or preventing symptoms."

While the research was carried out in aging mice, it holds immense potential for human brain function.

FTL1: A Key Driver Of Brain Aging

In the study, the researchers tracked shifts in genes and proteins in the hippocampus of mice. The FTL1 protein appeared consistently different between young and old animals.

Compared to young mice, the older mice showed higher levels of FTL1. They also had fewer connections between neurons in the hippocampus and performed worse on cognitive tests.

Increasing FTL1 levels in young mice produced brain changes similar to those seen in older mice. The researchers found that this change occurs because of alterations in the way nerve cells produce FTL1 protein.

In older mice, the nerve cells that produced high amounts of FTL1 developed simplified structures, forming short, single extensions instead of the complex, branching networks seen in healthy cells.

Further experiments showed that in older mice, higher levels of the protein slowed cellular metabolism in the hippocampus -- the part of the brain responsible for learning and memory.

However, when researchers treated these cells with a compound that boosts metabolism, the negative effects were prevented.

Also read: This Unique Diet Slows Brain Aging By Over 2 Years, Study Says

A Promise For Future Brain Aging Therapies

Villeda believes these findings could pave the way for treatments that target FTL1 and counter its effects in the brain.

"We're seeing more opportunities to alleviate the worst consequences of old age," he said. "It's a hopeful time to be working on the biology of aging."

Also read: Exercising Could Make Your Brain Younger, Says Doctor

Here's How To Boost Your Brain

• Simple movements like squats, push-ups or resistance band exercises
• Indulging in mentally challenging activities such as puzzles, reading, strategy games
• Learn new skills like any language, or musical instruments
• Better sleep — about 7-9 hours
• Healthy diet — rich in leafy greens, vegetables, berries, nuts, olive oil, whole grains, fish, beans, poultry
• meditation, deep breathing, or yoga
• Avoid smoking, and drinking alcohol.