Most people are aware of type 1 and type 2 diabetes, but did you know there is a type 3 diabetes as well! It is a more obscure term. Although it is not an accepted medical diagnosis, type 3 diabetes has been discussed in the literature as a possible relationship between insulin resistance in the brain and Alzheimer's disease. This link has been described to help explain how metabolic disorders impact brain health, causing cognitive decline and dementia.

What is Type 3 Diabetes?

Type 3 diabetes is more of a misnomer because it should not be confused with type 3c diabetes, which relates to pancreatic dysfunction. The term "type 3 diabetes," on the other hand, has been loosely used by some scientists to analogously propose that Alzheimer's disease is strongly implicated with insulin resistance in the brain.

This concept was conceptualized by Dr. Suzanne de la Monte and Dr. Jack Wands of Brown University in the year 2008. This hypothesis postulated that Alzheimer's disease may be called type 3 diabetes for it bears many similarities with glucose metabolism disorder type 2 diabetes. Their concept arises from the basic principle that insulin is fundamental to blood sugar regulation, but it is also the case with the brain. When brain cells become insulin-resistant, they lose access to glucose, impairing their function.

Research published in the Journal of Diabetes Science and Technology supports this hypothesis by indicating that insulin resistance can be a significant contributor to the occurrence of dementia, also referred to as Alzheimer's. The symptoms of memory loss and diminished reasoning are associated with impaired glucose metabolism in the body, especially in the cerebral tissue.

Symptoms of Type 3 Diabetes

Although type 3 diabetes is not a "medical term," its symptoms correlate well with Alzheimer's diseases that are known to reduce the ability to think in an efficient manner and bring down brain health. These signs are:

- Loss of memory, especially short-term.

- Poor judgment and judgment ability

- Failure in recognizing people or places familiar once.

- Failure in the process of reading, writing or processing numbers

- Anxiety, agitation, or mood changes.

- Disorganized thoughts or confusion

- Lack of impulse control

As the disease advances, patients may be afflicted with severe complications including an inability to swallow or control their bodily functions. In the final stages, most patients die from fatal complications such as aspiration pneumonia.

Causes of Type 3 Diabetes

This may not be well understood with regards to type 3 diabetes, or the exact link between insulin resistance and Alzheimer's disease. Some identified contributing factors include the following:

1. Insulin Resistance

Insulin acts as an important regulatory mechanism of brain functions such as memory and cognition. The reduction in insulin signaling may impair metabolism of brain cells, thus bringing about neurodegeneration.

2. Type 2 Diabetes

These diseases show a strong relationship and those individuals diagnosed with type 2 diabetes have double chances of getting Alzheimer's. In the two, the main causes can be chronic inflammation, oxidative stress, and a defect in glucose metabolism.

3. Environmental and Lifestyle Factors

Insulin resistance associated with obesity, stress, and an unhealthy diet is considered a cause that may increase the chances of Alzheimer's disease.

Researches in Frontiers in Neuroscience and The Lancet Neurology have also highlighted that drugs used for antidiabetic medication may be crucial for the prevention or at least slowing down the course of Alzheimer's.

Treatments for Type 3 Diabetes

In 2022, in a study in Pharmaceuticals, researchers studied biomarker uptake in brain regions implicated in the faulty uptake and metabolism of blood sugar in Alzheimer’s patients.

Emerging Therapies

Research into such treatments as intranasal insulin has also been promising. Intranasal delivery of insulin directly to the brain has been reported to enhance glucose uptake by brain cells, improve memory, and boost cognitive performance. While such clinical trials have been shown to be successful, additional research is needed for safety and efficacy.

Medications

For patients being aggressive or agitated, antipsychotic drugs may be prescribed; however, therapies such as cognitive rehabilitation as well as cognitive stimulation therapy serve to preserve memory and executive function.

Lifestyle Interventions

Diet, exercise, and stress management are critical in preventing and managing insulin resistance. A review in the Journal of Alzheimer's Disease also highlighted the benefits of Kirtan Kriya meditation, which can regulate genes involved in insulin and glucose metabolism, improve sleep, and reduce inflammation.

Can Type 3 Diabetes Be Prevented?

Although type 3 diabetes is not officially recognized, its connection to Alzheimer’s disease underscores the importance of proactive measures for brain health. Some prevention strategies include:

1. Healthy Diet

Consuming a balanced diet rich in antioxidants, whole grains, and healthy fats may support brain health.

2. Regular Exercise

Physical activity improves insulin sensitivity, reduces inflammation, and enhances overall metabolic health.

3. Stress Reduction

Mindfulness practices, including meditation, have been shown to lower stress levels, which can reduce the risk of cognitive decline.

The term type 3 diabetes brings out the complex relationship between metabolic disorders and brain health. Even though it is not a recognized medical condition, the concept emphasizes the crucial role of insulin in brain function and its possible contribution to Alzheimer's disease. Continued research will hopefully provide hope for therapies such as intranasal insulin and lifestyle modifications.

Are you a working professional? Have you been diagnosed with endometriosis? Worried about how this condition can impact your career? Well, don’t panic! We give you vital tips to manage the symptoms of endometriosis without compromising your professional aspirations. Dr. Kanika Gera Thakral, Consultant – Obstetrics & Gynaecology, Motherhood Hospitals, Greater Noida, spoke about the effects of endometriosis on working women and what women can do to not let the pain take a toll on their work life.

What is endometriosis?

Endometriosis happens when tissue similar to the lining of the uterus grows outside the uterus. These tissues commonly develop on the ovaries, fallopian tubes, or the pelvic lining. Endometriosis affects many women and can impact their daily lives, including their ability to work comfortably. Many women continue their professional responsibilities despite experiencing severe discomfort, fatigue, and pain.

Raising awareness about the condition and encouraging supportive workplaces can help women manage both their health and career more effectively. Since it is a progressive disorder, timely intervention remains key to managing it. In many cases, women live with symptoms for several years before receiving the correct diagnosis, which can delay treatment and affect their quality of life.

Read more: The Right Approach To Manage Endometriosis

The workplace challenge

Many working women who are diagnosed with endometriosis tend to experience symptoms such as pelvic pain, cramps, fatigue, nausea, and heavy menstrual cycles. These symptoms can make it difficult to maintain productivity at work, especially during flare-ups. Hence, women will be unable to concentrate on work or finish the tasks. Some may miss deadlines and meetings due to the painful symptoms. Women will have to skip going to work when the symptoms are intense and will have to rest at home. So, women living with endometriosis may face interruptions in their career growth and reduced working hours. But don’t worry, it is possible to manage this condition and give your best at work.

1. Long working hours, prolonged sitting, workplace stress, irregular meals, and lack of adequate rest can sometimes worsen symptoms of endometriosis.
2. Apart from physical discomfort, the condition can also affect emotional well-being. Living with chronic pain may lead to stress, anxiety, or frustration, which can indirectly impact workplace confidence and productivity.

Strategies for managing work and endometriosis

It is necessary for women with endometriosis to go for regular check-ups and follow-ups with the doctor. Women can continue to pursue their professional goals by adopting practical strategies to manage the condition. Open communication with employers when it comes to flexible schedules can help overcome stress and anxiety. Women should have access to remote working to avoid unnecessary travel due to pain.

The work-from-home option can be given to the women when needed by them. Planning demanding tasks during times of higher energy and maintaining a balanced daily routine can also improve productivity at work. Women should make sure to keep essential medications, a heating pad, or comfort aids at their desk to be able to relieve sudden discomfort. Likewise, using ergonomic seating or maintaining good posture while working may reduce pelvic and even back discomfort. Women should also connect to support groups that help to provide emotional reassurance and useful coping strategies that include yoga and meditation.

Lifestyle habits also play an important role. Regular physical activity, adequate sleep, stress-management techniques such as yoga or meditation, and following an anti-inflammatory diet rich in fruits, vegetables, whole grains, and healthy fats may help reduce flare-ups.

Read more: Women With Endometriosis Are Earning Less, Reveals Study

Treating endometriosis

Treatment is particularly based on the severity of symptoms. Women will be advised lifestyle modifications such as regular exercise, stress management, and an anti-inflammatory diet. Non-steroidal anti-inflammatory drugs may help reduce discomfort. Hormonal therapies may also be used to control symptoms. Some women will be advised to undergo laparoscopy to remove endometriotic cysts. Minimally invasive surgery can help remove lesions and restore pelvic anatomy, which may also improve fertility in some cases. In advanced cases, surgery can be recommended to women.

With timely care and supportive workplaces, women can pursue their ambitions without letting endometriosis interfere with their careers.

Four years after suffering from a rare neurological condition known as Stiff-Person Syndrome, Céline Dion, known for power ballads like My Heart Will Go On and Because You Loved Me, has announced her return to the stage.

The incurable condition had affected her singing voice and even her ability to walk.

In a message on her Instagram page, the singer announced plans to play a 10-night residency at the 40,000-capacity Paris La Défense Arena in September and October.

Calling her comeback "the best gift of my life", 58-year-old Dion said: "I'm doing great, managing my health, feeling good. I'm singing again, even doing a little bit of dancing.

"I'm so ready to do this. I'm feeling good, I'm strong, I'm feeling excited, obviously, [and] of course, a little nervous," she said, while thanking her fans for the “prayers and support, kindness and love”.

What Is Stiff Person Syndrome

Stiff-Person Syndrome is a neurological disease caused by the signals from the nerves to the muscles not working properly. It affects an estimated 8,000 people worldwide.

It is also an autoimmune is a neurological disease caused by the signals from the nerves to the muscles not working properly. It affects an estimated 8,000 people worldwide.

It is also an autoimmune condition, that is linked to diseases such as type 1 diabetes, thyroiditis, vitiligo, and pernicious anemia.

For some, it can be debilitating. SPS is progressive, meaning it gets worse over time. There is no known cure.

Common symptoms may include:

• Stiff muscles in the torso, arms, and legs
• Greater sensitivity to noise, touch, and emotional distress, which can set off muscle spasms

The condition is also more common among women than men, and affects people between the ages of 20 and 60.

While there is no known cure for SPS, current treatments such as intravenous immunoglobulin (IVIg) can help manage the symptoms.

Stiff-Person Syndrome: Celine Dion’s Diagnosis

Dion announced her diagnosed with Stiff Person Syndrome (SPS) in December 2022 in an emotional Instagram video. The condition had affected "every aspect of my daily life", she told her fans.

The best-selling artists of all time began noticing her symptoms, such as feeling "a little spasm" while performing on stage. She found her “voice was struggling", BBC reported.

Even though she experimented with her singing to ease the stress on her vocal cords, her condition worsened. She also began facing difficulties while walking.

"It's like somebody is strangling you. It's like somebody is pushing your larynx [or] pharynx," she told NBC News.

Determined to get back on her feet and sing, worked "all my body and soul, from head to toe, with a medical team", French Vogue magazine reported.

"Five days a week, I undergo athletic, physical, and vocal therapy. I work on my toes, my knees, my calves, my fingers, my singing, my voice."

The intense workouts enabled her to make a comeback at the 2024 Paris Olympics, singing Edith Piaf's classic Hymne à l'Amour from the Eiffel Tower.

While a hickey is generally harmless, in several shocking incidents, it has led to strokes and even death.

A hickey is typically a dark red or dark purple mark on your skin caused by intense suction.

According to health experts, the strong suction from the passionate love bite leads to blood clots that travel to the brain. It then blocks a vital artery and causes a embolic stroke.

Embolic stroke is a type of ischemic stroke caused by a blood clot or debris (embolus) that forms elsewhere in the body—often the heart—and travels through the bloodstream to block a blood vessel in the brain.

The Independent reported the case of 17-year-old Julio Macias Gonzalez, who suffered convulsions while eating dinner with his family after hanging out with his 24-year-old girlfriend and later died.

In a similar case reported from New Zealand, a 44-year-old woman suffered a stroke following a hickey.

While non-fatal, the 2010 study published in the New Zealand Medical Journal reported the medical condition “a rare phenomenon.”

In yet another case, the Danish Medical Journal reported the incident of a 35-year-old woman who experienced a sudden onset of right-sided weakness due to a left middle cerebral artery stroke 12 hours after she had obtained a love bite on the left side of her neck.

“Generally speaking, hickeys are simply superficial bruising, and there’s no scientific evidence available that could inform our thinking about this situation as it relates to stroke,” Teresa Roncon, spokeswoman for the Heart and Stroke Foundation of Canada, was quoted as saying Global News.

Is It Lethal?

While it's generally harmless, in some extreme cases, it can raise the risk of damaging the carotid or vertebral artery due to extreme pressure.

The carotid arteries, one on each side of the neck, are responsible for supplying blood to the head, including the brain. Vigorous manipulation of the neck, including the action of a hickey, can cause the inner wall of the carotid artery to rupture. (This process is medically termed as carotid artery dissection).

Such a dissection is a nidus, a place where bacteria can multiply, for the formation of a blood clot. The blood clot can then get dislodged and enter the brain circulation, eventually causing a stroke.

How Can A Hickey Go Wrong?

While there is nothing wrong with giving or receiving love bites, it is imperative to note that one should not dig their teeth too deeply into the other person's neck to avoid injury and damage to sensitive structures like the carotid artery or the jugular vein (a vein that carries deoxygenated blood from the skull to the body).

While there are practically no ways to cure a hickey, you can speed up the healing process. These processes can help you expedite the process:

• Alternate Cold and Warm Compresses
• Avoid Worsening The Hickey
• Massage The Area
• Use Topical Creams.