Most people are aware of type 1 and type 2 diabetes, but did you know there is a type 3 diabetes as well! It is a more obscure term. Although it is not an accepted medical diagnosis, type 3 diabetes has been discussed in the literature as a possible relationship between insulin resistance in the brain and Alzheimer's disease. This link has been described to help explain how metabolic disorders impact brain health, causing cognitive decline and dementia.

What is Type 3 Diabetes?

Type 3 diabetes is more of a misnomer because it should not be confused with type 3c diabetes, which relates to pancreatic dysfunction. The term "type 3 diabetes," on the other hand, has been loosely used by some scientists to analogously propose that Alzheimer's disease is strongly implicated with insulin resistance in the brain.

This concept was conceptualized by Dr. Suzanne de la Monte and Dr. Jack Wands of Brown University in the year 2008. This hypothesis postulated that Alzheimer's disease may be called type 3 diabetes for it bears many similarities with glucose metabolism disorder type 2 diabetes. Their concept arises from the basic principle that insulin is fundamental to blood sugar regulation, but it is also the case with the brain. When brain cells become insulin-resistant, they lose access to glucose, impairing their function.

Research published in the Journal of Diabetes Science and Technology supports this hypothesis by indicating that insulin resistance can be a significant contributor to the occurrence of dementia, also referred to as Alzheimer's. The symptoms of memory loss and diminished reasoning are associated with impaired glucose metabolism in the body, especially in the cerebral tissue.

Symptoms of Type 3 Diabetes

Although type 3 diabetes is not a "medical term," its symptoms correlate well with Alzheimer's diseases that are known to reduce the ability to think in an efficient manner and bring down brain health. These signs are:

- Loss of memory, especially short-term.

- Poor judgment and judgment ability

- Failure in recognizing people or places familiar once.

- Failure in the process of reading, writing or processing numbers

- Anxiety, agitation, or mood changes.

- Disorganized thoughts or confusion

- Lack of impulse control

As the disease advances, patients may be afflicted with severe complications including an inability to swallow or control their bodily functions. In the final stages, most patients die from fatal complications such as aspiration pneumonia.

Causes of Type 3 Diabetes

This may not be well understood with regards to type 3 diabetes, or the exact link between insulin resistance and Alzheimer's disease. Some identified contributing factors include the following:

1. Insulin Resistance

Insulin acts as an important regulatory mechanism of brain functions such as memory and cognition. The reduction in insulin signaling may impair metabolism of brain cells, thus bringing about neurodegeneration.

2. Type 2 Diabetes

These diseases show a strong relationship and those individuals diagnosed with type 2 diabetes have double chances of getting Alzheimer's. In the two, the main causes can be chronic inflammation, oxidative stress, and a defect in glucose metabolism.

3. Environmental and Lifestyle Factors

Insulin resistance associated with obesity, stress, and an unhealthy diet is considered a cause that may increase the chances of Alzheimer's disease.

Researches in Frontiers in Neuroscience and The Lancet Neurology have also highlighted that drugs used for antidiabetic medication may be crucial for the prevention or at least slowing down the course of Alzheimer's.

Treatments for Type 3 Diabetes

In 2022, in a study in Pharmaceuticals, researchers studied biomarker uptake in brain regions implicated in the faulty uptake and metabolism of blood sugar in Alzheimer’s patients.

Emerging Therapies

Research into such treatments as intranasal insulin has also been promising. Intranasal delivery of insulin directly to the brain has been reported to enhance glucose uptake by brain cells, improve memory, and boost cognitive performance. While such clinical trials have been shown to be successful, additional research is needed for safety and efficacy.

Medications

For patients being aggressive or agitated, antipsychotic drugs may be prescribed; however, therapies such as cognitive rehabilitation as well as cognitive stimulation therapy serve to preserve memory and executive function.

Lifestyle Interventions

Diet, exercise, and stress management are critical in preventing and managing insulin resistance. A review in the Journal of Alzheimer's Disease also highlighted the benefits of Kirtan Kriya meditation, which can regulate genes involved in insulin and glucose metabolism, improve sleep, and reduce inflammation.

Can Type 3 Diabetes Be Prevented?

Although type 3 diabetes is not officially recognized, its connection to Alzheimer’s disease underscores the importance of proactive measures for brain health. Some prevention strategies include:

1. Healthy Diet

Consuming a balanced diet rich in antioxidants, whole grains, and healthy fats may support brain health.

2. Regular Exercise

Physical activity improves insulin sensitivity, reduces inflammation, and enhances overall metabolic health.

3. Stress Reduction

Mindfulness practices, including meditation, have been shown to lower stress levels, which can reduce the risk of cognitive decline.

The term type 3 diabetes brings out the complex relationship between metabolic disorders and brain health. Even though it is not a recognized medical condition, the concept emphasizes the crucial role of insulin in brain function and its possible contribution to Alzheimer's disease. Continued research will hopefully provide hope for therapies such as intranasal insulin and lifestyle modifications.

This year, Nick Jonas has completed 20 years with type 1 diabetes. This is also the same year when his band, the Jonas Brothers have also hit the mark of 20th anniversary. Speaking to Healthline, Jonas said, "It is crazy hpw it lined up. It has been a wild journey in both... in the Brothers sense, it's been the ride of a lifetime, and we have been so fortunate to be able to do this for 20 years now and to have the support of the world's greatest fans."

He also revealed that he had great and some tough times too living with diabetes. There had been struggles of managing his low, however, he revealed that being the spokesperson of Dexcom, a healthcare company known for its glucose monitoring system, and through his own non-profit initiative Beyond Type 1, he has been joyful. “Overall, I’m really grateful to have been able to be transparent about [type 1] and to connect with all these wonderful people from all regions of the world who are experiencing their own diabetes journey, and it’s a really big thing to feel like you’re a little less alone in it,” said Jonas.

On World Diabetes Day, which was on November 14, Jonas took to the stage during a Jonas Brothers concert and shared the audience his A1C. This is a test that measures one's average blood sugar over the past 2 to 3 months. This number shows how well diabetes has been managed. He shared an inspiring message of hope, while giving a shoutout to his A1C. The concert was attended by Dexcom Warrior community, which makes more than 30,000 people who have been diagnosed with diabetes and may share the same experiences. “It was really special for me to get to use the Jonas Brothers’ platform as a place to speak about something that’s obviously very personal to me and on World Diabetes Day, I think it’s natural to get reflective and to tap into kind of what life looks like for me as a now 33-year-old person living with this disease,” he said.

He also dedicated the song 'A Little Bit Longer', that he had written very early on in his career during his diabetes journey. “It’s a really important time for me to get to speak on stage like that and play a song that I wrote about these experiences when I was 14 and to see the impact it still has to this day with the fan base,” he said.

Living With Type 1 Diabetes

Here are some strategies Jonas uses that helped him manage his diabetes. First off the list is to take the pressure off. “You’re never going to have the perfect day living with this disease and even if you’re super on top of your diabetes management, there are just things that are a little out of your control and being able to take a deep breath, reset, and know that it’s going to be OK on the other side is really important,” he said.

It may seem hard, but he said learning it in the beginning of his diagnosis helped him manage his diabetes. Then comes the care. He has focused on taking vitamins, caring for his skin, and most importantly, staying hydrated. “It’s a simple thing, but the more water I drink, my glucose levels are better. I don’t know exactly why, but I just find that hydrating has a lot of health benefits,” said Jonas. “I didn’t put as much focus on it earlier in my life as I do now, and it’s been really beneficial.”

Physical activity is a must. He walks for 30 minutes daily, or sometimes longer for his physical, mental, and emotional health. “It really centers me and even when it’s cold out, getting out in the fresh air is really important when a lot of my day too, is spent indoors for hours at venue or on a film set or something,” he said.

His focus on self, he says is the most important as he says he relies on his therapist from time to time. "I think it is really important to do that self-work". Lastly, he says everyone who has been diagnosed with diabetes, must take part in the community. “There will be good days, there will be tough days, but you can climb this mountain, and there’s some incredible people out there whose stories will really inspire anybody that’s going through tough moments,” said Jonas.

People prescribed venlafaxine are being urged to stay alert to certain symptoms and side effects that may require medical advice from NHS 111 or their GP. Venlafaxine is a widely used SNRI antidepressant. It is mainly prescribed for depression, but doctors may also recommend it for anxiety disorders and panic attacks.

What Is Venlafaxine?

Venlafaxine, sold under brand names such as Effexor and Effexor XR, is a prescription antidepressant classified as a serotonin-norepinephrine reuptake inhibitor. It helps regulate mood by raising levels of serotonin and norepinephrine in the brain, chemicals that play a key role in emotional balance and mental stability.

Doctors Warn People Taking Venlafaxine

The medicine is usually taken as a tablet or capsule. It works by increasing levels of serotonin and noradrenaline in the brain, chemicals that help regulate mood. According to NHS guidance, venlafaxine tends to cause fewer side effects than older antidepressants. That said, it is not completely free of risks.

Most people begin to notice some improvement within one to two weeks, although it can take four to six weeks for the drug to have its full effect.

Venlafaxine Side Effects

Common side effects listed by the NHS include sweating, nausea, a dry mouth, and headaches. These are generally mild and often ease as the body adjusts to the medication.

However, there are other, more serious side effects that may need prompt medical advice. While these reactions are uncommon and affect fewer than one in 100 people, the NHS advises contacting 111 or a GP if they occur.

Venlafaxine Serious Side Effects

NHS advice says you should speak to your GP if you notice unexpected weight gain or weight loss, or sudden changes to your menstrual cycle. This may include spotting, bleeding between periods, or unusually heavy periods.

Patients are also advised to contact their doctor or NHS 111 without delay if they experience any of the following symptoms while taking venlafaxine:

• Yellowing of the skin or the whites of the eyes
• Bleeding gums
• Bruising that appears without explanation or continues to spread
• Thoughts of self-harm or suicide
• Muscle pain or weakness with no clear cause
• Breathlessness, or a heartbeat that feels fast, uneven, or irregular
• Intense feelings of elation, extreme excitement, or restlessness that makes it hard to stay still
• Changes in vision, including blurred eyesight or enlarged pupils
• Coughing up blood
• Blood in urine
• Persistent headaches along with confusion, weakness, or repeated muscle cramps
• Black or red stools, or blood in vomit, which may point to internal bleeding

As adenovirus cases continue to rise globally, health professionals have noticed that this potentially serious infection is sometimes being mistaken for another illness, what many are calling the ‘super flu’.

For those unfamiliar, adenovirus is a DNA virus that gradually affects a person’s upper and lower respiratory tract, as well as other organs. This can include the eyes, digestive system, and kidneys.

Adenovirus Or Super Flu?

According to Dr. Deborah Lee at Dr Fox Online Pharmacy, who spoke to Cosmopolitan: "It spreads when someone breathes in infected droplets, touches the virus and then rubs their eyes, or through the faecal-oral route (not washing hands properly after using the toilet)."

"It moves quickly in crowded spaces where people are close together." She added, "The virus is resistant to soap and many commonly used cleaning products."

Adenovirus: What Are The Symptoms?

The reassuring news about adenovirus is that most people recover within a week or two. Its symptoms are often similar to those of a common cold.

Typical signs include fever, runny nose, sore throat, cough, shortness of breath, and swollen lymph nodes in the neck. In more severe cases, patients may also experience conjunctivitis, ear pain, diarrhea, vomiting, stomach aches, or urinary tract infections.

Certain groups are at higher risk of serious illness. Dr. Lee notes, "Babies and children under five, older adults, pregnant women, and people with weakened immune systems are the most vulnerable."

Although adenovirus symptoms often resemble those of a typical flu, it’s important to know when someone is dealing with the flu—or worse, the current ‘super flu’ that’s circulating widely.

How Does Adenovirus Differ From The 'Normal' Flu?

One way to tell the difference is by how long someone is sick. Adenovirus tends to develop gradually, whereas the ‘normal’ flu often hits suddenly, with high fever and intense symptoms within hours, Lee explains. Common flu symptoms also include a high temperature (38–40°C), severe headache, and extreme fatigue.

Other key differences: adenovirus can occur throughout the year, while flu is mostly seasonal. Adenovirus can also cause pink eye and gastrointestinal problems like vomiting or diarrhea, but it’s less likely to lead to serious complications compared to flu.

What About The 'Super Flu'?

Doctors say it’s not only the regular flu that needs to be distinguished from adenovirus, but also the current ‘super flu,’ which is causing particularly dramatic symptoms.

This infection is caused by the H3N2 virus and tends to be more severe than typical winter illnesses, especially in the UK.

"Past data shows H3N2 has been linked to more hospitalizations and deaths from flu, especially among adults over 65 and young children, compared with other flu types," Lee explained. When comparing the ‘super flu’ to adenovirus, she notes that the symptoms are very similar.

However, she stresses that the ‘super flu’ is considered much more intense. Not only can your sore throat feel agonizing, but aches and pains may be strong enough to confine you to bed.

Adenovirus vs Super Flu: Symptoms Explained

While adenovirus and the so-called ‘super flu’ can feel very similar, there are subtle differences to watch for. Adenovirus usually develops gradually, with fever, cough, sore throat, runny nose, and sometimes pink eye or digestive upset. Most healthy individuals recover within a week or two. In contrast, the ‘super flu,’ caused by the H3N2 virus, hits hard and fast—high fever, intense body aches, severe fatigue, and an agonizing sore throat are common.

Both illnesses can affect vulnerable groups such as young children, the elderly, and immunocompromised individuals, but the super flu tends to bring more extreme symptoms that may require hospitalization. Understanding these distinctions can help people recognize the illness early and seek appropriate care.