Most people are aware of type 1 and type 2 diabetes, but did you know there is a type 3 diabetes as well! It is a more obscure term. Although it is not an accepted medical diagnosis, type 3 diabetes has been discussed in the literature as a possible relationship between insulin resistance in the brain and Alzheimer's disease. This link has been described to help explain how metabolic disorders impact brain health, causing cognitive decline and dementia.

What is Type 3 Diabetes?

Type 3 diabetes is more of a misnomer because it should not be confused with type 3c diabetes, which relates to pancreatic dysfunction. The term "type 3 diabetes," on the other hand, has been loosely used by some scientists to analogously propose that Alzheimer's disease is strongly implicated with insulin resistance in the brain.

This concept was conceptualized by Dr. Suzanne de la Monte and Dr. Jack Wands of Brown University in the year 2008. This hypothesis postulated that Alzheimer's disease may be called type 3 diabetes for it bears many similarities with glucose metabolism disorder type 2 diabetes. Their concept arises from the basic principle that insulin is fundamental to blood sugar regulation, but it is also the case with the brain. When brain cells become insulin-resistant, they lose access to glucose, impairing their function.

Research published in the Journal of Diabetes Science and Technology supports this hypothesis by indicating that insulin resistance can be a significant contributor to the occurrence of dementia, also referred to as Alzheimer's. The symptoms of memory loss and diminished reasoning are associated with impaired glucose metabolism in the body, especially in the cerebral tissue.

Symptoms of Type 3 Diabetes

Although type 3 diabetes is not a "medical term," its symptoms correlate well with Alzheimer's diseases that are known to reduce the ability to think in an efficient manner and bring down brain health. These signs are:

- Loss of memory, especially short-term.

- Poor judgment and judgment ability

- Failure in recognizing people or places familiar once.

- Failure in the process of reading, writing or processing numbers

- Anxiety, agitation, or mood changes.

- Disorganized thoughts or confusion

- Lack of impulse control

As the disease advances, patients may be afflicted with severe complications including an inability to swallow or control their bodily functions. In the final stages, most patients die from fatal complications such as aspiration pneumonia.

Causes of Type 3 Diabetes

This may not be well understood with regards to type 3 diabetes, or the exact link between insulin resistance and Alzheimer's disease. Some identified contributing factors include the following:

1. Insulin Resistance

Insulin acts as an important regulatory mechanism of brain functions such as memory and cognition. The reduction in insulin signaling may impair metabolism of brain cells, thus bringing about neurodegeneration.

2. Type 2 Diabetes

These diseases show a strong relationship and those individuals diagnosed with type 2 diabetes have double chances of getting Alzheimer's. In the two, the main causes can be chronic inflammation, oxidative stress, and a defect in glucose metabolism.

3. Environmental and Lifestyle Factors

Insulin resistance associated with obesity, stress, and an unhealthy diet is considered a cause that may increase the chances of Alzheimer's disease.

Researches in Frontiers in Neuroscience and The Lancet Neurology have also highlighted that drugs used for antidiabetic medication may be crucial for the prevention or at least slowing down the course of Alzheimer's.

Treatments for Type 3 Diabetes

In 2022, in a study in Pharmaceuticals, researchers studied biomarker uptake in brain regions implicated in the faulty uptake and metabolism of blood sugar in Alzheimer’s patients.

Emerging Therapies

Research into such treatments as intranasal insulin has also been promising. Intranasal delivery of insulin directly to the brain has been reported to enhance glucose uptake by brain cells, improve memory, and boost cognitive performance. While such clinical trials have been shown to be successful, additional research is needed for safety and efficacy.

Medications

For patients being aggressive or agitated, antipsychotic drugs may be prescribed; however, therapies such as cognitive rehabilitation as well as cognitive stimulation therapy serve to preserve memory and executive function.

Lifestyle Interventions

Diet, exercise, and stress management are critical in preventing and managing insulin resistance. A review in the Journal of Alzheimer's Disease also highlighted the benefits of Kirtan Kriya meditation, which can regulate genes involved in insulin and glucose metabolism, improve sleep, and reduce inflammation.

Can Type 3 Diabetes Be Prevented?

Although type 3 diabetes is not officially recognized, its connection to Alzheimer’s disease underscores the importance of proactive measures for brain health. Some prevention strategies include:

1. Healthy Diet

Consuming a balanced diet rich in antioxidants, whole grains, and healthy fats may support brain health.

2. Regular Exercise

Physical activity improves insulin sensitivity, reduces inflammation, and enhances overall metabolic health.

3. Stress Reduction

Mindfulness practices, including meditation, have been shown to lower stress levels, which can reduce the risk of cognitive decline.

The term type 3 diabetes brings out the complex relationship between metabolic disorders and brain health. Even though it is not a recognized medical condition, the concept emphasizes the crucial role of insulin in brain function and its possible contribution to Alzheimer's disease. Continued research will hopefully provide hope for therapies such as intranasal insulin and lifestyle modifications.

While the National Capital is dealing with cold wave, the air quality also continues to worsen. In several parts of Delhi, the air quality reached severe category. The Indian Meteorological Department (IMD) also issued an Orange alert on Tuesday for cold wave. Dense fog also engulfed the city, with air pollution or the particulate matter being trapped in the air, turning the fog into smog.

The condition of air pollution in Delhi has remained concerning and the levels have spiked to 20 to 30 times above the safety levels recommended by the World Health Organization or the WHO. Many studies, including the official website of the Environmental Protection Agency (EPA), US notes that the small particulate matter found in the air pollution is directly linked to health problems. "Small particles less than 10 micrometers in diameter pose the greatest problems, because they can get deep into your lungs, and some may even get into your bloodstream," notes EPA.

The particulate matter could lead to:

• premature death in people with heart or lung disease
• nonfatal heart attacks
• aggravated asthma
• irregular heartbeat
• decreased lung function
• increases respiratory symptoms like irritation of the airways, coughing, or difficulty breathing

What Are Smog-Eating Surfaces And How Do They Help?

The government is pursuing "smog eating" surfaces to deal with the pollution problem in Delhi. While it may sound like a strange thing in India, not to the world. In fact, in the Netherlands these were used to reduce local nitrogen oxide or the NO concentrations in the air, rather than greenhouse gas concentrations.

Smog usually contains a mixture of hydrocarbons, ozone, oxides of nitrogen and sulphur, and particulates. The pollution is caused by both photochemical reactions that involve sunlight, unburned hydrocarbons and nitrogen oxides, along with high concentrations of particulate matter, especially from vehicle exhaust, construction dust and biomass burning.

Environment Minister Manjinder Singh Sirsa announced "smog eating" surface as part of its pollution control plan, for which the government has also signed an MoU with IIT Madras.

The smog eating surfaces will be public surfaces coated with photocatalytic materials like titanium dioxide or TiO2 that is used to degrade pollutants.

The Deccan Herald quoted Dr Pradeep Singh, professor and head at the School of Advanced Chemical Sciences, Shoolini University, who explained: Photocatalytic materials are basically semiconductors. Substances like TiO2₂or zinc oxide are typically used as photocatalysts. When light falls on these semiconductor catalysts, electrons within them jump from one energy level to another, creating a hole. These photocatalytic holes and electrons subsequently form free radicals, which have strong oxidizing properties and can break down certain air pollutants with which they interact."

How Do Smog Eating Surfaces Work?

Smog contains mainly nitric oxide, nitrogen dioxide, sulphur dioxide, ozone, and particulate matter. When all of these interact with photocatalytic materials, gaseous pollutants convert into less harmful compounds, such as nitrogen oxides become nitrates or decompose into ions. This process is also known as pollutant mineralization.

Fun Fact: It was in 2017, when scientists in Italy developed a type of photocatalytic cement that could absorb pollutants and convert it into harmless salts. Palazzo Italia in Milan, opened in 2015, was the first building to use the cement.

How Effective Are These Smog Eating Surfaces?

As per Dr Ashish Moon, Head of the Civil Department at Smt Radhikatai Pandav College of Engineering, Nagpur, the impact depends on environmental conditions. He explained that titanium dioxide can locally reduce certain gaseous pollutants like nitrogen oxides under ideal conditions, rather than absorbing up to 50 percent of all harmful gases.

He also co-authored a paper in 2021, titled: Detailed Case Study on Smog Eating Tile, where he noted, "It is better to use it in liquid form than a powder. I have not come across any harmful interactions between TiO2 and particles or gases in the air." However, he also points out that how it will work in Delhi will depend on its weather conditions and atmosphere. "There should be enough UV light for the nanoparticles to activate," he said.

Will this arrangement really work? That is yet to see, although a 2023 Spanish study found that although this measure showed some improvement, but it only yielded a modest reduction in ambient NO2. We are yet to see how well it will work in Delhi and its neighboring city's pollution problem.

As temperatures fall, a growing number of people are seeking medical advice for sudden, painful rashes and nerve-related discomfort. Superdrug Online Doctor has reported a 50% rise in patients requesting consultations for shingles over recent weeks. Shingles develops when the chickenpox virus, which stays dormant in the body after childhood infection, becomes active again later in life.

What Is Shingles?

Shingles, also known as herpes zoster, is a viral illness that causes a painful, blistering rash, usually appearing on one side of the body. It occurs when the varicella-zoster virus, which causes chickenpox, becomes active again after lying dormant in the nerves for many years. This reactivation is more likely when the immune system is weakened.

Symptoms often begin with burning, tingling, or itching in a specific area, followed by clusters of fluid-filled blisters that eventually dry out and form scabs. Starting antiviral treatment early can help reduce the severity and length of the infection. A shingles vaccine is also available and is recommended, particularly for people over the age of 50, to lower the risk of developing shingles and to prevent complications such as long-lasting nerve pain, known as postherpetic neuralgia.

Who Is Most At Risk Of Shingles?

The condition is more likely to affect older adults and people with weakened immune systems. Dr Babak Ashrafi, Superdrug’s Online Doctor, explained that many patients are caught off guard by how quickly symptoms appear. “Shingles often begins unexpectedly,” he said. “People may wake up with a burning or tingling sensation, followed by a rash that rapidly becomes more painful. We typically see higher numbers during colder months, when immune defences are under greater pressure.”

Winter-related factors such as stress, poor sleep, and seasonal infections can all take a toll on the immune system. When immunity dips, the virus responsible for shingles has a greater chance of reactivating, increasing the likelihood of flare-ups during colder periods.

Shingles Early Warning Signs To Watch For

According to the NHS, early symptoms of shingles often include a tingling, itching, or painful sensation on one side of the body. Some people may also experience headaches or feel generally unwell before a rash appears. The rash usually develops a few days later and is most commonly seen on the chest or abdomen, although it can occur anywhere on the body.

Superdrug Online Doctor has outlined five situations where people should seek prompt medical advice rather than rely on self-care. These include cases where:

• the rash appears on or near the eye
• pain is severe or spreading
• the person has a weakened immune system
• the individual is pregnant
• symptoms are worsening quickly

Shingles Treatment

Superdrug Online Doctor provides an online assessment and photo-diagnosis service, allowing clinicians to review symptoms remotely. Where appropriate, patients can be prescribed antiviral medication without needing to wait for a GP appointment.

Dr Ashrafi stressed the importance of acting quickly, adding: “The most important advice is not to wait and see. Starting treatment early can make a significant difference to recovery and long-term outcomes.”

Doctors are reporting a change in the way the flu is presenting as a new strain spreads across the UK. Hospital admissions linked to the flu rose sharply at the beginning of the year, with an average of 2,924 people a day admitted by January 4. Four hospital trusts have declared critical incidents, citing ongoing and intense pressure on services. These include three trusts in Surrey and one in Kent.

Surrey Heartlands Trust said winter pressures had been made worse by a rise in flu and norovirus cases. NHS national medical director Professor Meghana Pandit said the situation remains difficult, with hospitals seeing another increase in patients admitted with flu and other respiratory infections last week.

She said it is still vital for people to seek medical help when needed and reminded the public that there are many chances to get vaccinated against flu. Health Secretary Wes Streeting also stressed that flu can be dangerous, especially for older adults, young children, and those with existing health problems. He urged everyone who qualifies to get their flu vaccine as soon as possible, calling it the best form of protection.

Doctors Report Unusual Symptoms As New Flu Strain Spreads Across The UK

Doctors say this latest flu strain appears to be causing different symptoms. The virus, known as subclade K, is a variant of the A H3N2 type of influenza.

Dr Mark Loafman told NBC Chicago that many patients are experiencing much higher fevers than usual. He said the fever can last five to seven days, which is longer than people typically expect and is a cause for concern.

In some cases, doctors say the fever does not respond well to common medicines such as paracetamol or ibuprofen. Lung specialist Dr Juanita Mora said this strain is linked to very high temperatures, a severe and persistent cough with heavy phlegm, vomiting, diarrhoea, and widespread joint and muscle pain.

Doctors have also noticed a rise in stomach-related symptoms, including nausea and vomiting, often referred to as gastrointestinal or GI issues. Dr Loafman said that, based on what doctors are seeing, adults infected with the subclade K strain seem to be showing more signs of GI illness than usual.

According to the NHS, flu symptoms usually appear suddenly and tend to be much more severe than those of a common cold. While most people start to recover within about a week, the illness can feel particularly harsh while it lasts.

Key Symptoms of Flu

The main symptoms usually begin abruptly and include:

• A sudden high temperature of 38C or higher
• Body aches affecting muscles and joints
• Extreme tiredness or exhaustion
• A dry cough
• A sore throat
• Headaches
• Problems sleeping
• Reduced appetite
• Nausea, vomiting, or diarrhoea, which are more common in children

How To Treat Flu at Home

Most people can deal with flu symptoms at home without needing to see a doctor. The NHS advises the following self-care measures:

• Rest and Sleep: Allow your body time and energy to fight off the infection.
• Stay Warm: Use extra layers or blankets to maintain body warmth.
• Hydration: Drink plenty of fluids to prevent dehydration. Your urine should be pale yellow or clear.
• Pain Relief: Paracetamol or ibuprofen can help reduce fever and ease aches. Avoid taking combination flu medicines alongside paracetamol tablets, as this can lead to taking too much.
• Sore Throat Relief: Gargle with salt water if you are an adult, or have hot drinks such as lemon and honey to ease discomfort.