Most people are aware of type 1 and type 2 diabetes, but did you know there is a type 3 diabetes as well! It is a more obscure term. Although it is not an accepted medical diagnosis, type 3 diabetes has been discussed in the literature as a possible relationship between insulin resistance in the brain and Alzheimer's disease. This link has been described to help explain how metabolic disorders impact brain health, causing cognitive decline and dementia.

What is Type 3 Diabetes?

Type 3 diabetes is more of a misnomer because it should not be confused with type 3c diabetes, which relates to pancreatic dysfunction. The term "type 3 diabetes," on the other hand, has been loosely used by some scientists to analogously propose that Alzheimer's disease is strongly implicated with insulin resistance in the brain.

This concept was conceptualized by Dr. Suzanne de la Monte and Dr. Jack Wands of Brown University in the year 2008. This hypothesis postulated that Alzheimer's disease may be called type 3 diabetes for it bears many similarities with glucose metabolism disorder type 2 diabetes. Their concept arises from the basic principle that insulin is fundamental to blood sugar regulation, but it is also the case with the brain. When brain cells become insulin-resistant, they lose access to glucose, impairing their function.

Research published in the Journal of Diabetes Science and Technology supports this hypothesis by indicating that insulin resistance can be a significant contributor to the occurrence of dementia, also referred to as Alzheimer's. The symptoms of memory loss and diminished reasoning are associated with impaired glucose metabolism in the body, especially in the cerebral tissue.

Symptoms of Type 3 Diabetes

Although type 3 diabetes is not a "medical term," its symptoms correlate well with Alzheimer's diseases that are known to reduce the ability to think in an efficient manner and bring down brain health. These signs are:

- Loss of memory, especially short-term.

- Poor judgment and judgment ability

- Failure in recognizing people or places familiar once.

- Failure in the process of reading, writing or processing numbers

- Anxiety, agitation, or mood changes.

- Disorganized thoughts or confusion

- Lack of impulse control

As the disease advances, patients may be afflicted with severe complications including an inability to swallow or control their bodily functions. In the final stages, most patients die from fatal complications such as aspiration pneumonia.

Causes of Type 3 Diabetes

This may not be well understood with regards to type 3 diabetes, or the exact link between insulin resistance and Alzheimer's disease. Some identified contributing factors include the following:

1. Insulin Resistance

Insulin acts as an important regulatory mechanism of brain functions such as memory and cognition. The reduction in insulin signaling may impair metabolism of brain cells, thus bringing about neurodegeneration.

2. Type 2 Diabetes

These diseases show a strong relationship and those individuals diagnosed with type 2 diabetes have double chances of getting Alzheimer's. In the two, the main causes can be chronic inflammation, oxidative stress, and a defect in glucose metabolism.

3. Environmental and Lifestyle Factors

Insulin resistance associated with obesity, stress, and an unhealthy diet is considered a cause that may increase the chances of Alzheimer's disease.

Researches in Frontiers in Neuroscience and The Lancet Neurology have also highlighted that drugs used for antidiabetic medication may be crucial for the prevention or at least slowing down the course of Alzheimer's.

Treatments for Type 3 Diabetes

In 2022, in a study in Pharmaceuticals, researchers studied biomarker uptake in brain regions implicated in the faulty uptake and metabolism of blood sugar in Alzheimer’s patients.

Emerging Therapies

Research into such treatments as intranasal insulin has also been promising. Intranasal delivery of insulin directly to the brain has been reported to enhance glucose uptake by brain cells, improve memory, and boost cognitive performance. While such clinical trials have been shown to be successful, additional research is needed for safety and efficacy.

Medications

For patients being aggressive or agitated, antipsychotic drugs may be prescribed; however, therapies such as cognitive rehabilitation as well as cognitive stimulation therapy serve to preserve memory and executive function.

Lifestyle Interventions

Diet, exercise, and stress management are critical in preventing and managing insulin resistance. A review in the Journal of Alzheimer's Disease also highlighted the benefits of Kirtan Kriya meditation, which can regulate genes involved in insulin and glucose metabolism, improve sleep, and reduce inflammation.

Can Type 3 Diabetes Be Prevented?

Although type 3 diabetes is not officially recognized, its connection to Alzheimer’s disease underscores the importance of proactive measures for brain health. Some prevention strategies include:

1. Healthy Diet

Consuming a balanced diet rich in antioxidants, whole grains, and healthy fats may support brain health.

2. Regular Exercise

Physical activity improves insulin sensitivity, reduces inflammation, and enhances overall metabolic health.

3. Stress Reduction

Mindfulness practices, including meditation, have been shown to lower stress levels, which can reduce the risk of cognitive decline.

The term type 3 diabetes brings out the complex relationship between metabolic disorders and brain health. Even though it is not a recognized medical condition, the concept emphasizes the crucial role of insulin in brain function and its possible contribution to Alzheimer's disease. Continued research will hopefully provide hope for therapies such as intranasal insulin and lifestyle modifications.

Ozempic, Mounjaro, Wegovy, and many more such popular weight loss drugs are now making headlines. They are also dominating social media, dinner table conversation and many more. But, is Ozempic truly a medical breakthrough, a miracle drug? Dr Shubham Vatsya, a gastroenterologist, and hepatologist at Fortis Vasant Kunj explains how did this drug change the weight loss struggle that many people face.

Why Is GLP-1 Drug A Medical Breakthrough?

Dr Vatsya explains that it took 20 years of research for scientists to come up with these medicines. This drug underwent proper lengthy trials, and have been approved by the US Food and Drug Administration (FDA), "which is not obtained by giving any bribe".

Also Read: Fact Check: Is Weight Lifting Safe for Teens? An Expert Explains the Risks and Safer Alternatives

He also noted that when a person is not able to lose weight, Ozempic and drugs alike give a "head start" to them, along with a hope.

Talking about side effects, he says that every drug has its side effects, this is where a doctor's role comes in.

"Now, the person who is not able to lose weight, if you tell him 'you hit 100 kg bench press', he will break his shoulder. He needs a kickstart somewhere. This is what weight loss drugs allow," he says.

He also points out that the scientists who made GLP-1 agonists got a Nobel Prize, which "cannot be a scam". This is what makes weight loss drugs truly different.

What Are GLP-1 Drugs?

GLP-1 Drugs stand for Glucagon-like peptide 1, a naturally occurring hormones that helps regulate blood sugar and appetite after eating. It was first identified almost 50 years ago and scientists have since uncovered its role in type 2 diabetes.

Almost two decades of research went behind it that led to the development of GLP-1 agonists. It was in 2005, when the first GLP-1 medication, exenatide was approved.

Read: Could You Become Addicted To Your Weight Loss Drugs?

These medications have three main functions:

• Stimulating the pancreas to release insulin
• Slow the transit of food in the stomach to help people feel fuller for longer after a meal
• Act on areas of the brain that regulates hunger and fullness, leading to smaller portion sizes and reducing cravings

Popular drugs like Ozempic and Wgovy, which have semaglutide, which is a GLP-1 receptor agonist, or tirzepatide found in Zepbound and Mounjaro are FDA-approved for type 2 diabetes and weight loss.

These drugs work by binding GLP-1 receptors in the body, which in return increase insulin production in response to food intake and suppress glucagon, a hormones that raises blood sugar.

Also Read: How Weight Loss Drugs Change Ones Relationship With Food?

Are The Popular Weight Loss Drugs Addictive?

There is currently no data suggesting that GLP-1 medications cause physiological addiction. Interestingly, some research suggests they may even reduce cravings related to alcohol or opioid use. That directly contradicts the idea that these drugs hijack the brain’s reward system in a traditional addictive way.

Still, wanting or feeling unable to stop a medication because of fear of weight regain or loss of control is very real. That experience should not be dismissed, even if it is not addiction in the clinical sense.

These medications are meant to support long-term habit change, not replace it. Nutrition, movement, sleep, and a healthier relationship with food are meant to develop alongside the medication. When people reach their goal weight, doctors may suggest tapering the dose slowly or moving to a lower maintenance schedule rather than stopping abruptly.

Stopping suddenly can make hunger feel overwhelming. A gradual transition allows the body and mind time to adjust. Some people do successfully maintain weight loss without the medication, but it usually requires strong lifestyle foundations first.

As cough and flu season sweeps across the UK, health expert Dr Xand shared crucial guidance during today’s episode of BBC Morning Live (Jan 19) for anyone struggling with a stubborn cough. The discussion focused on coughs and colds, highlighting new research showing that human rhinovirus, a common cause of cold, can also trigger pneumonia in adults.

Flu Season In UK: Warning Signs To Watch For

Speaking with presenters Helen Skelton and Gethin Jones, as per Mirror, Dr Xand, a specialist in public and global health, explained which symptoms indicate a cough should not be ignored. He noted that a persistent cough is one of the key signs of pneumonia.

Gethin asked, "A cough happens with many illnesses, so when should someone really worry?" Dr Xand replied, "This is a big question, and plenty of people at home might be thinking, 'Is this serious?' because coughs can linger for a long time."

He continued: "Viruses like respiratory syncytial virus (RSV) can cause what’s known as the 'hundred-day cough,' and people can be coughing for weeks wondering what’s going on."

Dr Xand advised viewers to follow the NHS guidelines for coughs, saying, "The NHS recommends consulting your doctor if a cough persists for over three weeks. Many coughs last three to four weeks, and you’ll usually notice if they’re improving. Right now, the most common cause is a virus."

Dr Xand’s Cough Syrup Alert

Addressing people from home about cough syrups, Dr Xand highlighted the latest NHS guidance. He suggested trying more natural remedies, which can be just as effective. "The NHS does not actually recommend cough syrup," he explained. "It advises hot lemon with honey instead."

The official NHS website confirms that "hot lemon with honey has a similar effect to cough medicines." This simple remedy can soothe the throat, calm irritation, and reduce the cough reflex. Some studies even suggest it works as effectively as certain over-the-counter medicines, particularly for children over one year old. However, it’s important to note that it doesn’t treat the underlying illness.

What Do Cough Syrup Studies Show?

Research shows that most over-the-counter cough medicines offer minimal benefits. Studies, including those from the Cochrane Collaboration, reveal that they perform little better than a placebo for short-term cough relief in both adults and children.

While these syrups may temporarily ease throat irritation or provide a sense of relief, ingredients such as dextromethorphan and guaifenesin often do no better than sugar pills. Much of the perceived benefit comes from the placebo effect or the body’s natural recovery.

Instead, simpler measures like honey, staying hydrated, and using painkillers such as paracetamol or ibuprofen are often more effective. Most coughs caused by colds simply need time to resolve.

Cough Syrup: Red Flags To Watch For

Dr Xand shared the warning signs people should be aware of. "There are several red flags worth noting. High fever, chills, or unexplained shortness of breath are all reasons to see a doctor immediately. You should be able to breathe normally, and if you can’t, that’s a concern."

He added, "Any chest pain with a cough, very thick mucus, or extreme fatigue are also serious signs. More severe warning signals include trouble breathing, bluish lips or fingertips, confusion, mental changes, prolonged high fever, and a rapid heart rate."

"It’s crucial to act quickly," Dr Xand continued. "I’ve seen cases in my own family where someone went from a mild cough to being extremely unwell in just a day. Sudden deterioration can be life-threatening, so early medical help is essential."

Pneumonia Can Be Subtle but Serious

Dr Xand emphasized, "Pneumonia can sometimes develop quietly. It isn’t always dramatic, but it can be fatal. That’s why it’s so important to monitor symptoms and seek medical help promptly if things are getting worse."

Vitamin deficiencies are often brushed aside as minor nutritional gaps. Many people assume they can be fixed later or ignored until something feels seriously wrong. According to Dr Prabhat Ranjan Sinha, Senior Consultant, Internal Medicine at Aakash Healthcare, this casual attitude can be risky, especially when it comes to Vitamin D3 and Vitamin B12. Both nutrients play a central role in bone strength, nerve function, immunity, and energy levels. When their levels drop, the damage may build quietly and surface only when daily life starts to feel difficult.

Vitamin D3 and Vitamin B12 are essential for overall wellbeing. Their deficiency may not cause obvious symptoms at first, but over time they can affect how the body functions, how often a person falls sick, and how energetic or mentally sharp they feel.

Vitamin B12 And D3 Deficiencies: The Sunshine Vitamin And Why It Matters

Vitamin D3, often called the sunshine vitamin, is produced by the body when skin is exposed to sunlight. Along with calcium, it helps maintain strong bones and reduces the risk of fractures. Low levels of Vitamin D3 can weaken muscles, increase the risk of falls, and raise the chances of bone disorders such as osteoporosis. In children, severe deficiency can lead to rickets, a condition that affects normal bone growth.

Dr Sinha explains that Vitamin D3 does more than support bone health. It also plays a key role in immune function. People with low levels may fall sick more often and take longer to recover from infections. Research has also linked deficiency to higher levels of inflammation in the body.

Despite living in a country with abundant sunlight, Vitamin D3 deficiency is widespread. Urban lifestyles keep many people indoors for long hours. Regular use of sunscreen, limited outdoor activity, and aging all reduce the body’s ability to produce and absorb this vitamin. Diet alone rarely provides enough Vitamin D3, which is why deficiency remains common even among people who eat well.

Vitamin B12 And Its Silent Impact

Vitamin B12 is equally important but often overlooked. It is essential for nerve health, brain function, and the production of healthy red blood cells. Unlike some deficiencies that show early warning signs, B12 deficiency tends to develop slowly. Its symptoms are often mistaken for stress, aging, or routine fatigue.

Low Vitamin B12 levels can cause weakness, persistent tiredness, tingling or numbness in the hands and feet, memory problems, mood changes, and difficulty concentrating. Over time, untreated deficiency can lead to nerve damage and anemia.

Certain groups are at higher risk. Vegetarians and vegans often do not get enough B12 because it is mainly found in animal-based foods. Older adults may struggle to absorb B12 due to reduced stomach acid. People with digestive disorders and those taking long-term acid-reducing medications are also more vulnerable.

Why These Deficiencies Are Missed?

One of the biggest challenges with Vitamin D3 and B12 deficiencies is that their symptoms overlap with many common health complaints. Ongoing fatigue, joint pain, low mood, or frequent illness are often blamed on work stress, poor sleep, or lifestyle habits. As a result, people delay medical advice until symptoms start interfering with everyday life.

Dr Sinha notes that this delay can make recovery slower and complications more likely.

Vitamin B12 And D3 Deficiencies Diagnosis And Timely Care

Simple blood tests can accurately detect Vitamin D3 and B12 deficiencies. However, many people only get tested once symptoms become severe. Early diagnosis allows for timely treatment, which may include supplements, dietary changes, and lifestyle adjustments under medical guidance.

Addressing these deficiencies early is one of the simplest ways to protect long-term health. Adequate sunlight exposure, balanced nutrition, and routine screening can help maintain healthy levels. Taking Vitamin D3 and B12 deficiencies seriously is a small step that can prevent lasting health problems and support healthier aging.