Most people are aware of type 1 and type 2 diabetes, but did you know there is a type 3 diabetes as well! It is a more obscure term. Although it is not an accepted medical diagnosis, type 3 diabetes has been discussed in the literature as a possible relationship between insulin resistance in the brain and Alzheimer's disease. This link has been described to help explain how metabolic disorders impact brain health, causing cognitive decline and dementia.

What is Type 3 Diabetes?

Type 3 diabetes is more of a misnomer because it should not be confused with type 3c diabetes, which relates to pancreatic dysfunction. The term "type 3 diabetes," on the other hand, has been loosely used by some scientists to analogously propose that Alzheimer's disease is strongly implicated with insulin resistance in the brain.

This concept was conceptualized by Dr. Suzanne de la Monte and Dr. Jack Wands of Brown University in the year 2008. This hypothesis postulated that Alzheimer's disease may be called type 3 diabetes for it bears many similarities with glucose metabolism disorder type 2 diabetes. Their concept arises from the basic principle that insulin is fundamental to blood sugar regulation, but it is also the case with the brain. When brain cells become insulin-resistant, they lose access to glucose, impairing their function.

Research published in the Journal of Diabetes Science and Technology supports this hypothesis by indicating that insulin resistance can be a significant contributor to the occurrence of dementia, also referred to as Alzheimer's. The symptoms of memory loss and diminished reasoning are associated with impaired glucose metabolism in the body, especially in the cerebral tissue.

Symptoms of Type 3 Diabetes

Although type 3 diabetes is not a "medical term," its symptoms correlate well with Alzheimer's diseases that are known to reduce the ability to think in an efficient manner and bring down brain health. These signs are:

- Loss of memory, especially short-term.

- Poor judgment and judgment ability

- Failure in recognizing people or places familiar once.

- Failure in the process of reading, writing or processing numbers

- Anxiety, agitation, or mood changes.

- Disorganized thoughts or confusion

- Lack of impulse control

As the disease advances, patients may be afflicted with severe complications including an inability to swallow or control their bodily functions. In the final stages, most patients die from fatal complications such as aspiration pneumonia.

Causes of Type 3 Diabetes

This may not be well understood with regards to type 3 diabetes, or the exact link between insulin resistance and Alzheimer's disease. Some identified contributing factors include the following:

1. Insulin Resistance

Insulin acts as an important regulatory mechanism of brain functions such as memory and cognition. The reduction in insulin signaling may impair metabolism of brain cells, thus bringing about neurodegeneration.

2. Type 2 Diabetes

These diseases show a strong relationship and those individuals diagnosed with type 2 diabetes have double chances of getting Alzheimer's. In the two, the main causes can be chronic inflammation, oxidative stress, and a defect in glucose metabolism.

3. Environmental and Lifestyle Factors

Insulin resistance associated with obesity, stress, and an unhealthy diet is considered a cause that may increase the chances of Alzheimer's disease.

Researches in Frontiers in Neuroscience and The Lancet Neurology have also highlighted that drugs used for antidiabetic medication may be crucial for the prevention or at least slowing down the course of Alzheimer's.

Treatments for Type 3 Diabetes

In 2022, in a study in Pharmaceuticals, researchers studied biomarker uptake in brain regions implicated in the faulty uptake and metabolism of blood sugar in Alzheimer’s patients.

Emerging Therapies

Research into such treatments as intranasal insulin has also been promising. Intranasal delivery of insulin directly to the brain has been reported to enhance glucose uptake by brain cells, improve memory, and boost cognitive performance. While such clinical trials have been shown to be successful, additional research is needed for safety and efficacy.

Medications

For patients being aggressive or agitated, antipsychotic drugs may be prescribed; however, therapies such as cognitive rehabilitation as well as cognitive stimulation therapy serve to preserve memory and executive function.

Lifestyle Interventions

Diet, exercise, and stress management are critical in preventing and managing insulin resistance. A review in the Journal of Alzheimer's Disease also highlighted the benefits of Kirtan Kriya meditation, which can regulate genes involved in insulin and glucose metabolism, improve sleep, and reduce inflammation.

Can Type 3 Diabetes Be Prevented?

Although type 3 diabetes is not officially recognized, its connection to Alzheimer’s disease underscores the importance of proactive measures for brain health. Some prevention strategies include:

1. Healthy Diet

Consuming a balanced diet rich in antioxidants, whole grains, and healthy fats may support brain health.

2. Regular Exercise

Physical activity improves insulin sensitivity, reduces inflammation, and enhances overall metabolic health.

3. Stress Reduction

Mindfulness practices, including meditation, have been shown to lower stress levels, which can reduce the risk of cognitive decline.

The term type 3 diabetes brings out the complex relationship between metabolic disorders and brain health. Even though it is not a recognized medical condition, the concept emphasizes the crucial role of insulin in brain function and its possible contribution to Alzheimer's disease. Continued research will hopefully provide hope for therapies such as intranasal insulin and lifestyle modifications.

In a recent video, a neurosurgeon listed things he would start doing if he had to work on his brain health, ‘rebuilding it’, from scratch. Many people are focusing on health and bringing about a change in their life so that their health doesn’t suffer. If you wish to do the same but do not know where to start from, Dr Jay Jagannathan, MD, from Jay Jagannathan, MD, explains five easy steps with which you can start.

Your brain health is affected by many things around you, your habits, your diet, who you spend your time with etc. In the video Dr Jaggannath listed 5 things he would start doing if he had to start working on his brain health from the beginning.

In the caption he explained, “After years in neurosurgery, I’ve learned this: Your brain doesn’t need perfection — it needs consistency, balance, and protection. And the biggest changes often come from the simplest habits.”

5 Ways To Rebuild Your Brain Health

five key steps they would take to completely reset and improve their brain health. These strategies focus on combining strict discipline with intentional rest and mindful activities, recognizing the direct connection between physical habits and mental performance.

Sleep Schedule Discipline

The first and most critical step is maintaining strict sleep schedule discipline. This means committing to getting at least six to eight hours of quality sleep every single night without fail. If the individual has a very early start to their day, they must prioritize going to bed much earlier to ensure they meet this crucial rest quota. Prioritizing consistent sleep is essential for the brain to consolidate memories and perform necessary repairs.

Prioritize Strength Training

The second action involves incorporating regular, low-grade resistance (strength) training into the weekly routine. This exercise is especially important for people who spend long hours on their feet, like surgeons. Committing to low-grade resistance training for at least two to three days per week is considered extremely vital because physical strength and exercise directly support better circulation and overall body health, which feeds directly into improved brain function.

Embrace Regular Meditation and Mind-Body Connection

The neurosurgeon stressed the importance of dedicated time for regular meditation. They pointed out that a strong mind-body interface is crucial for endurance and clarity, particularly in demanding fields like surgery. Therefore, engaging in mindful practices such as yoga or meditation is necessary to establish and maintain that vital connection, allowing the brain and body to work together harmoniously and manage high stress levels.

Avoiding Burnout Cycles

The fourth piece of advice is to actively and consciously avoid burnout cycles. Burnout is a dangerous state of chronic stress that can severely damage both the brain's structure and its ability to function effectively. This strategy requires setting firm boundaries and intentionally managing one's workload and stress levels to prevent ever reaching a point of complete mental and physical exhaustion.

Skip the "Hero" Lifestyle

Finally, the fifth point is to firmly reject the "hero lifestyle" of skipping rest. This is the common, misguided habit of trying to power through intense work periods by constantly sacrificing necessary sleep and rest days. The neurosurgeon advises against this trend, asserting that continuous rest and consistent recovery are not optional but are absolutely non-negotiable for achieving and maintaining sustained high performance and long-term brain health.

With different careers come different work expectations. Some jobs have routine day shifts with regular working hours, popularly known as the ‘9-5’. While other jobs require round-the-clock service. However, did you know what shifts you chose to do have an effect on your health as well?

Ranking the best to worst shifts, Dr Sudhir Kumar, a Hyderabad-based neurologist, recently made a post on his social media platform. He explained that the way you schedule your work shifts can have a major impact on your long-term health. The ideal work schedule is one that matches your body's natural clock. Below is a ranking of three common shift types, based on their effects on your health.

Day Shifts: The Healthiest Option

Why Day Shifts are Best for Your Body

Working during the day perfectly matches your circadian rhythm, or internal clock. Your body is naturally built to be awake when it's light and rest when it's dark, allowing vital processes like hormone production and cell repair to function efficiently and keep your system stable.

Benefits of a Stable Schedule

Day shifts allow for quality, full sleep, which is crucial for long-term health. Workers face a lower risk of serious issues like obesity, diabetes, high blood pressure, and heart disease. This stable routine also lowers the risk of depression, anxiety, and certain cancers, making it the healthiest choice.

Fixed Night Shifts: Acceptable but Not Ideal

Partial Adaptation to Night Work

If night work is unavoidable, a consistent fixed night shift is superior to a constantly changing schedule. The benefit is that the body can establish a slightly more consistent sleep routine over time, allowing for a better partial adjustment to the reversed daytime sleep schedule than an erratic one.

Significant Remaining Health Risks

However, stable night shifts still cause chronic misalignment with the natural day-night cycle. This leads to higher long-term risks of metabolic disorders, insulin resistance, and mood problems. Additionally, it disrupts social and family life, contributing to ongoing sleep deprivation and substantial health risks.

Rotating Shifts: The Worst for Health

Maximum Disruption to the Body Clock

Constantly changing shifts are the most harmful because the internal clock cannot adapt to the varying schedule. This causes the maximum possible circadian rhythm disruption, confusing the body about when it should be awake, resting, or performing essential processes.

Increased Risk of Serious Illness

This chaotic schedule is linked to severe sleep issues and unhealthy fluctuations in stress hormones. This increases the risk of serious illnesses, including cardiovascular disease, diabetes, and mood disorders. Rapid shifts, like moving from night to morning duty, dangerously increase fatigue, raising the risk of accidents.

Final Ranking for Long-Term Health

At the end of the post Dr Kumar reiterated that the best to worst working hours for your body.

• Day Shift (Best)
• Fixed Night Shifts (Moderate Risk)
• Rotating Shifts (Worst Risk)

While there are ways to manage your health around your working hours, it is important to make sure you give your body as much stability as possible. Make sure you speak to a healthcare professional and build a routine that will help your body maintain its level of functioning while also keeping your health in check.

Have you or someone around you experienced nightly leg cramps that disrupt their sleep? While you may think of it as harmless, it is more dangerous than you realize. Warning people about the same, in a recent video on social media, Dr. Rema Malik Board-Certified Vascular Surgeon in Houston, reveals that this persistent, painful nighttime leg cramps are often a distress signal from your blood vessels, not just a simple mineral imbalance.

The doctor explains that this is not just a simple case of ‘charley horse’, which are muscle cramps that occur in the body, often legs. It is a phenomenon where the muscles in the body go through a spasm, meaning it contracts without your control and does not relax. While these may be the cause behind your leg cramps at night, there could be more to it than you realize.

What Causes Night Leg Cramps?

The most common reason for nighttime cramping is Venous Insufficiency. This condition occurs when the tiny one-way valves inside the leg veins weaken or become damaged. After spending hours sitting or standing throughout the day, these faulty valves allow blood to flow backward and pool in the lower legs due to gravity.

At night, this buildup of stagnant blood and fluid, which is full of metabolic waste products, irritates the local nerves and muscles. This irritation then triggers the intense, involuntary muscle contractions known as cramps, and it is also often associated with that uncomfortable, crawling sensation known as "restless legs."

Why Are Night Leg Cramps Dangerous?

A more serious cause of these cramps is Peripheral Artery Disease (PAD), particularly in its advanced stages, which is sometimes referred to as "rest pain." PAD develops when the arteries supplying blood to the legs become narrow or blocked by plaque buildup (atherosclerosis).

When the leg muscles are not receiving enough oxygen-rich blood—a state called ischemia—they begin to signal distress. If the blockage is severe, the muscles can be starved of oxygen even when the body is completely at rest, leading to crippling pain that serves as a critical, limb-threatening warning sign that requires urgent medical investigation.

Why You Should Not Ignore Random Aches And Pains

It is important to understand that persistent nighttime leg cramps should not be dismissed as simply a "normal part of aging."

While the risk of vascular issues like Venous Insufficiency increases after age 40 and PAD after age 50, the pain is a clear message from the body that something is structurally wrong with the blood vessels.

Ignoring this persistent pain can lead to serious health complications down the line. Therefore, if these cramps are a regular occurrence, seeking a consultation with a specialist, like a vascular surgeon, is necessary to correctly diagnose the underlying cause and begin appropriate treatment.

When Should You Get Your Muscle Cramps Checked?

According to MedlinePlus, most muscle cramps are harmless and disappear quickly, usually within a few minutes. However, you should call your doctor or healthcare provider if your cramps become severe or happen frequently. It's also important to seek medical attention if the cramps don't improve after stretching or drinking enough water, last a long time, or if they occur along with other concerning symptoms such as swelling, redness, a warm feeling in the area, or if you also experience muscle weakness.