Most people are aware of type 1 and type 2 diabetes, but did you know there is a type 3 diabetes as well! It is a more obscure term. Although it is not an accepted medical diagnosis, type 3 diabetes has been discussed in the literature as a possible relationship between insulin resistance in the brain and Alzheimer's disease. This link has been described to help explain how metabolic disorders impact brain health, causing cognitive decline and dementia.

What is Type 3 Diabetes?

Type 3 diabetes is more of a misnomer because it should not be confused with type 3c diabetes, which relates to pancreatic dysfunction. The term "type 3 diabetes," on the other hand, has been loosely used by some scientists to analogously propose that Alzheimer's disease is strongly implicated with insulin resistance in the brain.

This concept was conceptualized by Dr. Suzanne de la Monte and Dr. Jack Wands of Brown University in the year 2008. This hypothesis postulated that Alzheimer's disease may be called type 3 diabetes for it bears many similarities with glucose metabolism disorder type 2 diabetes. Their concept arises from the basic principle that insulin is fundamental to blood sugar regulation, but it is also the case with the brain. When brain cells become insulin-resistant, they lose access to glucose, impairing their function.

Research published in the Journal of Diabetes Science and Technology supports this hypothesis by indicating that insulin resistance can be a significant contributor to the occurrence of dementia, also referred to as Alzheimer's. The symptoms of memory loss and diminished reasoning are associated with impaired glucose metabolism in the body, especially in the cerebral tissue.

Symptoms of Type 3 Diabetes

Although type 3 diabetes is not a "medical term," its symptoms correlate well with Alzheimer's diseases that are known to reduce the ability to think in an efficient manner and bring down brain health. These signs are:

- Loss of memory, especially short-term.

- Poor judgment and judgment ability

- Failure in recognizing people or places familiar once.

- Failure in the process of reading, writing or processing numbers

- Anxiety, agitation, or mood changes.

- Disorganized thoughts or confusion

- Lack of impulse control

As the disease advances, patients may be afflicted with severe complications including an inability to swallow or control their bodily functions. In the final stages, most patients die from fatal complications such as aspiration pneumonia.

Causes of Type 3 Diabetes

This may not be well understood with regards to type 3 diabetes, or the exact link between insulin resistance and Alzheimer's disease. Some identified contributing factors include the following:

1. Insulin Resistance

Insulin acts as an important regulatory mechanism of brain functions such as memory and cognition. The reduction in insulin signaling may impair metabolism of brain cells, thus bringing about neurodegeneration.

2. Type 2 Diabetes

These diseases show a strong relationship and those individuals diagnosed with type 2 diabetes have double chances of getting Alzheimer's. In the two, the main causes can be chronic inflammation, oxidative stress, and a defect in glucose metabolism.

3. Environmental and Lifestyle Factors

Insulin resistance associated with obesity, stress, and an unhealthy diet is considered a cause that may increase the chances of Alzheimer's disease.

Researches in Frontiers in Neuroscience and The Lancet Neurology have also highlighted that drugs used for antidiabetic medication may be crucial for the prevention or at least slowing down the course of Alzheimer's.

Treatments for Type 3 Diabetes

In 2022, in a study in Pharmaceuticals, researchers studied biomarker uptake in brain regions implicated in the faulty uptake and metabolism of blood sugar in Alzheimer’s patients.

Emerging Therapies

Research into such treatments as intranasal insulin has also been promising. Intranasal delivery of insulin directly to the brain has been reported to enhance glucose uptake by brain cells, improve memory, and boost cognitive performance. While such clinical trials have been shown to be successful, additional research is needed for safety and efficacy.

Medications

For patients being aggressive or agitated, antipsychotic drugs may be prescribed; however, therapies such as cognitive rehabilitation as well as cognitive stimulation therapy serve to preserve memory and executive function.

Lifestyle Interventions

Diet, exercise, and stress management are critical in preventing and managing insulin resistance. A review in the Journal of Alzheimer's Disease also highlighted the benefits of Kirtan Kriya meditation, which can regulate genes involved in insulin and glucose metabolism, improve sleep, and reduce inflammation.

Can Type 3 Diabetes Be Prevented?

Although type 3 diabetes is not officially recognized, its connection to Alzheimer’s disease underscores the importance of proactive measures for brain health. Some prevention strategies include:

1. Healthy Diet

Consuming a balanced diet rich in antioxidants, whole grains, and healthy fats may support brain health.

2. Regular Exercise

Physical activity improves insulin sensitivity, reduces inflammation, and enhances overall metabolic health.

3. Stress Reduction

Mindfulness practices, including meditation, have been shown to lower stress levels, which can reduce the risk of cognitive decline.

The term type 3 diabetes brings out the complex relationship between metabolic disorders and brain health. Even though it is not a recognized medical condition, the concept emphasizes the crucial role of insulin in brain function and its possible contribution to Alzheimer's disease. Continued research will hopefully provide hope for therapies such as intranasal insulin and lifestyle modifications.

Catching a cold during winter is fairly common because viruses spread more easily in packed indoor settings, and cold weather can weaken the immune defence inside the nose, making it harder to fight infections. Having a stuffy nose or a mild cough is one thing, but many people often confuse their illness with a cold when it may actually be flu. Flu symptoms are usually more intense and can include fever, headaches and body aches, along with a dry cough and sore throat. A cold, on the other hand, tends to peak within two to three days, with recovery usually taking about a week.

Cold vs Flu: Why Knowing the Difference Matters

With a strong flu strain causing disruption across the UK, knowing how to tell the difference between a cold and flu has become especially important. Berkshire NHS, which has around 17,100 followers on TikTok, has outlined three key differences between the two illnesses.

In a caption, the community NHS trust said: “Cold and flu symptoms can look similar, but flu is usually more severe. The flu vaccine helps protect against flu. Visit the NHS website to learn more.”

NHS Shares 3 Symptoms to Tell Cold and Flu Apart

The video features an NHS staff member pointing out three signs as she walks toward the correct option. The first is that flu comes on suddenly, often within a few hours, while a cold mainly affects the nose and throat. The final sign is that flu can leave you feeling drained and too unwell to go about your normal routine.

Can Flu Get Better on Its Own?

Flu often clears up on its own, but it can make some people very unwell. That is why it is important to get vaccinated if you are advised to do so and to follow safe distancing to reduce the spread of infection.

Flu Symptoms 2025

As per NHS, below are the flu symptoms that people need to take care of:

• A sudden high temperature
• An aching body
• Feeling tired or exhausted
• A dry cough
• A sore throat
• A headache
• Difficulty sleeping
• Loss of appetite
• Diarrhoea or tummy pain
• Feeling sick and being sick

What Are The Symptoms Of A Cold?

• A blocked or runny nose
• Sneezing
• A sore throat
• A hoarse voice
• A cough
• Feeling tired and unwell
• A high temperature
• Aching muscles
• A loss of taste and smell
• A feeling of pressure in your ears and face

How Long Does a Cold Last?

In most cases, a cold can be managed at home without seeing a GP. You should start to feel better within one to two weeks, with symptoms developing over two to three days.

Cold Symptoms in Children: What Parents Should Know

Cold symptoms can last longer in young children. They may become more irritable, struggle with eating and sleeping, breathe through their mouth, and sometimes vomit after coughing. As per NHS, try to get enough rest over the Christmas holidays if possible, drink plenty of fluids, and eat nourishing food to help lower the risk of illness.

Mothers who use minoxidil, a widely used hair loss treatment, may increase the risk of infantile hypertrichosis in babies, a condition marked by excessive hair growth across the body, including areas where hair does not usually grow, according to a large international analysis.

Minoxidil Use by Mothers Linked To Potential Health Risks In Infants

Researchers from the Ministry of Health and Family Welfare and the All India Institute of Medical Sciences (AIIMS), New Delhi, reviewed 2,664 worldwide reports of suspected infantile hypertrichosis linked to minoxidil. Of these, 45 cases involved children aged between birth and 23 months.

The analysis showed that 22.2 per cent of these infant cases were associated with maternal exposure to minoxidil. Accidental exposure accounted for 44.4 per cent, while the cause remained unclear in 33.3 per cent of cases. The findings were published in the Archives of Dermatological Research.

What Is Minoxidil?

Minoxidil is a drug most commonly used to treat pattern hair loss, known as androgenetic alopecia, in both men and women. In higher oral doses, it is also prescribed for severe high blood pressure. The medicine works as a vasodilator, meaning it helps widen blood vessels to improve blood flow.

What Is Infantile Hypertrichosis?

Infantile hypertrichosis (also called childhood hypertrichosis or werewolf syndrome) is a rare condition marked by excessive hair growth on the face, back, arms, and other areas, appearing from infancy, often with a genetic cause but sometimes triggered by medications (like minoxidil) or underlying conditions, leading to significant cosmetic and psychological distress despite being a generally harmless cosmetic issue

Minoxidil: Eye-Related Side Effects Also Reported

The study also highlighted concerns beyond infant cases. Researchers identified 1,669 global reports of eye-related adverse effects linked to minoxidil use in the general population, including 25 cases reported from India.

Commonly reported eye symptoms included swelling of the eyelids, blurred vision, and central serous chorioretinopathy, a condition in which fluid accumulates beneath the retina and can affect eyesight.

Background on Minoxidil

Minoxidil was originally developed to treat high blood pressure. It was later reformulated as a topical treatment for hair loss in both men and women after its hair growth–stimulating side effects were observed. The drug is typically applied directly to the scalp or affected skin areas, the researchers noted.

Minoxidil: Concerns Over Regulation and Use

Despite its proven effectiveness, the researchers raised concerns about the drug’s widespread over-the-counter availability and limited regulatory oversight. These factors, they said, increase the risk of misuse and unintended exposure.

Although minoxidil is generally advised against for use during pregnancy and breastfeeding, the analysis still identified cases of infantile hypertrichosis linked to maternal exposure during these periods.

The researchers noted that minoxidil has also been associated with eye-related side effects in the broader population, prompting renewed questions about its overall safety profile.

“This study aims to examine global reports of infantile hypertrichosis associated with maternal minoxidil exposure and to assess serious and non-serious eye disorder cases reported in India, with the aim of improving awareness about the risks of early-life or accidental exposure,” the authors wrote.

The study was based on data collected up to March 2025 from VigiBase, the World Health Organization’s global database of suspected adverse drug reactions.

This year had been a year of flu, fiver, bacterial illness and more. One of the over the counter medicine that many people often buy, or is prescribed, especially for bacterial infections is Amoxicillin.

What Is Amoxicillin?

It is a widely prescribed antibiotic that is used to treat bacterial infections in children and adults. It is part of the penicillin class of medications and it inhibits the growth of bacteria and allows the immune system to efficiently eliminate the infection. It is commonly used to treat bacterial infections affecting the respiratory tract, urinary tract, and skin.

However, about 5 to 10 per cent of children prescribed this may develop skin rashes as a common side effect. A rash can develop in two forms: allergic and non-allergic. A rash from the drug Amoxicillin could last up to a week.

What Kind Of Rashes Are Caused By Amoxicillin?

A Maculopapular rash is a flat rash that occurs like red patches, raised bumps and spreads over the body.

Hives are itchy, raised red or skin-colored welts that can change shape and location.

Erythema Multiforme are more severe, featuring target-like lesions or bull's-eye shapes with central red spot, pale ring, and red outer ring.

Anaphylactic Reaction is a rare but severe allergic reaction that includes symptoms like difficulty in breathing, swelling of the face, lips, or tongue, hives and rapid drop in blood pressure.

Non-Allergic Amoxicillin Rash are flat, red spots that may be slightly raised, but not harmful. These usually appear o the 5th to 7th day after the start of amoxicillin and can appear on the chest, abdomen, back, face, arms, and legs. It may get worse before it starts to get better.

What Signs Should You Look Out For?

Warning signs include rashes within two hours of the first amoxicillin dose, difficulty breathing or swallowing, or very itchy hives.

The allergic reaction is caused by one's immune system reacting to that medication as if it were a foreign invader in the body.

More girls than boys develop these rashes, and in children this is even more common. In fact, the rash by amoxicillin was first noted in 1960s, in children who were being treated with ampicillin, recorded the Journal of Pediatrics.

What Can You Do If You Get Amoxicillin Rashes?

Among treatment, the first step should be to see your physician and immediately stop taking the medication. Drinking water and enough fluids can also help. Your doctor too would prescribe you medications and lotions to soothe your itching.

Hives can also be treated with the over the counter drug Benadryl. However, you must go see your doctor or GP, and not self medicate.

A doctor may treat the rash in various ways, including stopping the medication as the first line of defense. Then the doctor may give oral antihistamines (e.g., cetirizine) for the itch. Some doctors may use topical steroids to help with the itch and redness.

Before visiting your doctor, take photos of your rash, send it to your GP, as if it is contagious. Even after you start the treatment, stay in touch with your healthcare provider for any development.