Most people are aware of type 1 and type 2 diabetes, but did you know there is a type 3 diabetes as well! It is a more obscure term. Although it is not an accepted medical diagnosis, type 3 diabetes has been discussed in the literature as a possible relationship between insulin resistance in the brain and Alzheimer's disease. This link has been described to help explain how metabolic disorders impact brain health, causing cognitive decline and dementia.

What is Type 3 Diabetes?

Type 3 diabetes is more of a misnomer because it should not be confused with type 3c diabetes, which relates to pancreatic dysfunction. The term "type 3 diabetes," on the other hand, has been loosely used by some scientists to analogously propose that Alzheimer's disease is strongly implicated with insulin resistance in the brain.

This concept was conceptualized by Dr. Suzanne de la Monte and Dr. Jack Wands of Brown University in the year 2008. This hypothesis postulated that Alzheimer's disease may be called type 3 diabetes for it bears many similarities with glucose metabolism disorder type 2 diabetes. Their concept arises from the basic principle that insulin is fundamental to blood sugar regulation, but it is also the case with the brain. When brain cells become insulin-resistant, they lose access to glucose, impairing their function.

Research published in the Journal of Diabetes Science and Technology supports this hypothesis by indicating that insulin resistance can be a significant contributor to the occurrence of dementia, also referred to as Alzheimer's. The symptoms of memory loss and diminished reasoning are associated with impaired glucose metabolism in the body, especially in the cerebral tissue.

Symptoms of Type 3 Diabetes

Although type 3 diabetes is not a "medical term," its symptoms correlate well with Alzheimer's diseases that are known to reduce the ability to think in an efficient manner and bring down brain health. These signs are:

- Loss of memory, especially short-term.

- Poor judgment and judgment ability

- Failure in recognizing people or places familiar once.

- Failure in the process of reading, writing or processing numbers

- Anxiety, agitation, or mood changes.

- Disorganized thoughts or confusion

- Lack of impulse control

As the disease advances, patients may be afflicted with severe complications including an inability to swallow or control their bodily functions. In the final stages, most patients die from fatal complications such as aspiration pneumonia.

Causes of Type 3 Diabetes

This may not be well understood with regards to type 3 diabetes, or the exact link between insulin resistance and Alzheimer's disease. Some identified contributing factors include the following:

1. Insulin Resistance

Insulin acts as an important regulatory mechanism of brain functions such as memory and cognition. The reduction in insulin signaling may impair metabolism of brain cells, thus bringing about neurodegeneration.

2. Type 2 Diabetes

These diseases show a strong relationship and those individuals diagnosed with type 2 diabetes have double chances of getting Alzheimer's. In the two, the main causes can be chronic inflammation, oxidative stress, and a defect in glucose metabolism.

3. Environmental and Lifestyle Factors

Insulin resistance associated with obesity, stress, and an unhealthy diet is considered a cause that may increase the chances of Alzheimer's disease.

Researches in Frontiers in Neuroscience and The Lancet Neurology have also highlighted that drugs used for antidiabetic medication may be crucial for the prevention or at least slowing down the course of Alzheimer's.

Treatments for Type 3 Diabetes

In 2022, in a study in Pharmaceuticals, researchers studied biomarker uptake in brain regions implicated in the faulty uptake and metabolism of blood sugar in Alzheimer’s patients.

Emerging Therapies

Research into such treatments as intranasal insulin has also been promising. Intranasal delivery of insulin directly to the brain has been reported to enhance glucose uptake by brain cells, improve memory, and boost cognitive performance. While such clinical trials have been shown to be successful, additional research is needed for safety and efficacy.

Medications

For patients being aggressive or agitated, antipsychotic drugs may be prescribed; however, therapies such as cognitive rehabilitation as well as cognitive stimulation therapy serve to preserve memory and executive function.

Lifestyle Interventions

Diet, exercise, and stress management are critical in preventing and managing insulin resistance. A review in the Journal of Alzheimer's Disease also highlighted the benefits of Kirtan Kriya meditation, which can regulate genes involved in insulin and glucose metabolism, improve sleep, and reduce inflammation.

Can Type 3 Diabetes Be Prevented?

Although type 3 diabetes is not officially recognized, its connection to Alzheimer’s disease underscores the importance of proactive measures for brain health. Some prevention strategies include:

1. Healthy Diet

Consuming a balanced diet rich in antioxidants, whole grains, and healthy fats may support brain health.

2. Regular Exercise

Physical activity improves insulin sensitivity, reduces inflammation, and enhances overall metabolic health.

3. Stress Reduction

Mindfulness practices, including meditation, have been shown to lower stress levels, which can reduce the risk of cognitive decline.

The term type 3 diabetes brings out the complex relationship between metabolic disorders and brain health. Even though it is not a recognized medical condition, the concept emphasizes the crucial role of insulin in brain function and its possible contribution to Alzheimer's disease. Continued research will hopefully provide hope for therapies such as intranasal insulin and lifestyle modifications.

Reality television personality Nicole “Snooki” Polizzi has revealed she has been diagnosed with stage-one cervical cancer after undergoing further testing for previously detected abnormal cells.

The Jersey Shore alum shared in a Feb. 20 TikTok video that a cone biopsy confirmed adenocarcinoma, a type of cancer that develops in gland-lining cells. Doctors discovered the disease less than a month after she first announced the presence of cancerous cervical cells.

“Not the news I was hoping for,” the 38-year-old said, adding that the early detection significantly improved her outlook.

Detected Early After Years Of Tests

Polizzi said she had experienced abnormal Pap smear results for several years before undergoing the procedure that led to the diagnosis. She encouraged followers not to delay screenings out of fear or discomfort, noting early detection made the cancer potentially curable.

Medical teams also informed her that the cancer had not spread deeper into the cervix — an encouraging sign — though adenocarcinoma can be more aggressive and may spread to lymph nodes if untreated.

Further Scans And Likely Surgery

Doctors have scheduled a PET scan to determine whether the cancer has spread elsewhere in the body. Depending on the findings, treatment options include chemotherapy, radiation or surgery.

Polizzi said she is leaning toward a hysterectomy, the surgical removal of the uterus, describing it as the most sensible course of action.

Message to Fans: Don’t Skip Screenings

The television star, a mother of three, thanked supporters for their encouragement and said she plans to keep sharing updates during treatment.

She also stressed the importance of routine check-ups, calling cervical cancer “nothing to joke about” and urging people to seek timely testing, even when it feels uncomfortable or frightening.

What Is Cervical Cancer?

Cervical cancer, also known as cancer of the cervix, begins on the surface of the cervix and involves the growth of abnormal cells in its lining. Cervical cancer is primarily caused by infection with the human papillomavirus (HPV), which is preventable with a vaccine.

There are three main types of cervical cancer:

• Squamous cell carcinoma: This type forms in the lining of the cervix and accounts for about 70% of cases.
• Adenocarcinoma: This type forms in the cells that produce mucus and is less common.
• Mixed carcinoma: This type has features of both squamous cell carcinoma and adenocarcinoma.

Preventive measures, including the HPV vaccine and regular screenings, are crucial in reducing the risk of cervical cancer. Early detection and treatment significantly improve the chances of successful outcomes.

Symptoms of Cervical Cancer

In its early stages, cervical cancer typically doesn’t show any symptoms, which is why regular screening is important to catch it at this stage. Once symptoms do start appearing, they include abnormal vaginal bleeding (in between periods) and unusual vaginal discharge. Pain during sex in the pelvic region is another common symptom. As the cancer worsens, patients may experience more severe symptoms like weight loss, fatigue and leg swelling.

Precancerous changes in cervical cells rarely cause symptoms. The only way to detect abnormal cells that may develop into cancer is through a cervical screening test. If these early cell changes progress into cervical cancer, the most common signs include:

• Vaginal bleeding between periods
• Menstrual bleeding that is longer or heavier than usual
• Pain during intercourse
• Bleeding after intercourse
• Pelvic pain
• Changes in vaginal discharge, such as increased discharge or discharge with a strong or unusual color or smell
• Vaginal bleeding after menopause

These symptoms can be caused by other conditions, but if you are worried or symptoms persist, it is essential to contact your doctor. This is important for anyone with a cervix, including individuals who are straight, lesbian, gay, bisexual, or transgender.

Early signs of cervical cancer can include:

• Pain during sex
• Unusual vaginal bleeding, such as after sex, between periods, after menopause, or following a pelvic exam
• Unusual vaginal discharge that is watery, bloody, and/or has a strong odour

As cervical cancer progresses, it can cause additional symptoms, such as:

• Pelvic pain
• Trouble urinating
• Swollen legs
• Kidney failure
• Bone pain
• Weight loss and lack of appetite
• Fatigue
• Backache
• Stomach pain

It is crucial to note that you might not notice symptoms of cervical cancer until it has advanced. Regular screenings and prompt medical consultation for any concerning symptoms are vital for early detection and effective treatment.

Adolescents who use cannabis could face a significantly higher risk of developing psychotic (doubled), bipolar (doubled), depressive and anxiety disorders, a study shows.

Researchers from Kaiser Permanente, the Public Health Institute's Getting it Right from the Start, the University of California, San Francisco and the University of Southern California, who studied 463,396 adolescents ages 13 to 17 through age 26, found that children between these ages were extremely prone to developing mental illnesses.

Lynn Silver, MD, program director of the Getting it Right from the Start, a program of the Public Health Institute, and study co-author noted: "As cannabis becomes more potent and aggressively marketed, this study indicates that adolescent cannabis use is associated with double the risk of incident psychotic and bipolar disorders, two of the most serious mental health conditions.

"The evidence increasingly points to the need for an urgent public health response - one that reduces product potency, prioritizes prevention, limits youth exposure and marketing and treats adolescent cannabis use as a serious health issue, not a benign behavior."

"Even after accounting for prior mental health conditions and other substance use, adolescents who reported cannabis use had a substantially higher risk of developing psychiatric disorders - particularly psychotic and bipolar disorders.

"This study adds to the growing body of evidence that cannabis use during adolescence could have potentially detrimental, long-term health effects. It's imperative that parents and their children have accurate, trusted, and evidence-based information about the risks of adolescent cannabis use," Kelly Young-Wolff, Ph.D., lead author of the study and senior research scientist at the Kaiser Permanente Division of Research, added.

The observational US-focused study also found that cannabis use was more common among adolescents enrolled in Medicaid and those living in more socioeconomically deprived neighborhoods.

How Does Cannabis Usage In Teens Affect Overall Health?

Strong links have also been found between adolescent cannabis use and mental health issues, including increased risk of depression, anxiety, and, in some cases, schizophrenia or other psychotic disorders.

Additionally, smoking cannabis can lead to breathing problems similar to tobacco, such as chronic bronchitis. It can also cause an increased heart rate, and some studies suggest a higher risk of heart attacks.

Early initiation, especially before age 16, increases the risk of developing Cannabis Use Disorder (addiction). High-potency products can lead to rapid onset of withdrawal symptoms, mood changes, and even physical complications like Cannabis Hyperemesis Syndrome (severe nausea/vomiting)

Why Should Early Cannabis Usage Be Discouraged?

Compared to teens who don't use cannabis, those who do are more likely to drop out of high school or not finish a college degree. Using cannabis can cause several immediate and long-term problems for teens:

• Difficulty Thinking
• Memory Issues
• Poor Coordination
• Attention Problems
• School and Social Troubles
• Cannabis use can also lead to more serious issues that affect a teen's overall life.
• Increased Mental Health Risks

Driving under the influence of cannabis is illegal and unsafe, as it severely slows reaction time. Cannabis reduces coordination and concentration, impacting all the skills necessary for responsible and safe driving.

Around 30 percent of cannabis users are also known to develop an addiction (cannabis use disorder). Failing to quit or choosing the drug over family activities are signs. This risk is higher for frequent teen users.

Scientists have created a three-dimensional "heart-on-a-chip" (HOC) model that beats on its own, uses calcium to initiate muscular activity and responds predictably to common drugs in hopes that it will help fight against cardiovascular diseases and heart failure.

This engineered heart is the first to incorporate a dual-sensing platform that provides real-time tracking of activity throughout the heart tissue down to the cellular level, helping scientists measure cellular function, which is critical for preventing heart failure in patients with CVDs.

First author Ali Mousavi, a biomedical engineer at the University of Montreal: "The ability to observe the tissue's response to different compounds in real time represents a major advantage for preclinical development and translational research."

To create their heart-on-chip (HOC) models, researchers collected heart muscle and connective tissue cells from rats. They placed the cells in a gel rich in proteins and nutrients to help them grow, then put them onto tiny, flexible silicon chips.

To measure how the tissue worked, they used two types of sensors. First, they attached the engineered heart tissue between two small elastic pillars. Each time the tissue beat, the pillars bent slightly, and this bending showed how strong the heartbeat was.

Then they placed tiny, soft gel-based sensors inside the tissue. These very small droplets—about 50 micrometers wide—changed shape as the cells contracted. This allowed the researchers to measure mechanical stress at the level of individual cells.

Talking about this development, senior author Houman Savoji, a mechanical and biomedical engineer at the University of Montreal said: "This breakthrough brings us even closer to true precision health by giving us the ability to identify the most effective medication for each person before treatment is even administered."

The Rising Heart Attack Crisis

During a heart attack, a lack of blood flow causes the cells and tissue in the heart muscle to die, leading to irreversible damage that can result in serious complications like arrhythmias, heart failure, cardiogenic shock, or cardiac arrest.

It is one of the leading causes of death in the country. Four Indians experience a heart attack every minute, with one in four dying of the cause. Experts have also noticed a rising trend of nearly 50 percent of heart attack patients being under the age of 40, with half of all heart attacks in Indian men occurring under 50.

Coronary Artery Disease: The Silent KillerCoronary artery disease (CAD) is one of the most common illnesses that can cause a heart attack in people. It develops over years and has no clear signs and symptoms apart from a heart attack.

The illness begins due to a buildup of fats, cholesterol and other substances known as plaque in and on the artery walls.

Over time, this can cause narrowing or blockage of the coronary arteries and block the supply of oxygen-rich blood to the heart which can lead to chest pain (angina), shortness of breath and ultimately, heart attacks.

READ MORE: How This Chinese Medicine Can Improve Blood Flow In Angina Patients

Typically, those above the age of 45, having a biological family member with heart disease, lack of sleep, smoking, consuming saturated fats along with other autoimmune diseases such as lupus and rheumatoid arthritis, can increase the risk of developing CAD.

Nearly one in 10 Indian adults suffer from CAD and about two million people die from the disease annually. Apart from this, about 18 to 20 million American adults aged 20 and older are also affected about the disease.

How Much You Should Exercise To Prevent CAD?

Moreover, regular exercise can also reduce the risk of Type 2 diabetes, high blood pressure, dementia and Alzheimer’s as well as several types of cancer. It can also help improve sleep, cognition, including memory, attention and processing speed.

Dr Hayes recommends opting for a cardiac evaluation such as an electrocardiogram, or EKG; a stress test; a cardiac MRI or CT scan to generate images of your heart if you notice changes in your ability to exercise or cannot perform consistent levels of exercise.