Most people are aware of type 1 and type 2 diabetes, but did you know there is a type 3 diabetes as well! It is a more obscure term. Although it is not an accepted medical diagnosis, type 3 diabetes has been discussed in the literature as a possible relationship between insulin resistance in the brain and Alzheimer's disease. This link has been described to help explain how metabolic disorders impact brain health, causing cognitive decline and dementia.

What is Type 3 Diabetes?

Type 3 diabetes is more of a misnomer because it should not be confused with type 3c diabetes, which relates to pancreatic dysfunction. The term "type 3 diabetes," on the other hand, has been loosely used by some scientists to analogously propose that Alzheimer's disease is strongly implicated with insulin resistance in the brain.

This concept was conceptualized by Dr. Suzanne de la Monte and Dr. Jack Wands of Brown University in the year 2008. This hypothesis postulated that Alzheimer's disease may be called type 3 diabetes for it bears many similarities with glucose metabolism disorder type 2 diabetes. Their concept arises from the basic principle that insulin is fundamental to blood sugar regulation, but it is also the case with the brain. When brain cells become insulin-resistant, they lose access to glucose, impairing their function.

Research published in the Journal of Diabetes Science and Technology supports this hypothesis by indicating that insulin resistance can be a significant contributor to the occurrence of dementia, also referred to as Alzheimer's. The symptoms of memory loss and diminished reasoning are associated with impaired glucose metabolism in the body, especially in the cerebral tissue.

Symptoms of Type 3 Diabetes

Although type 3 diabetes is not a "medical term," its symptoms correlate well with Alzheimer's diseases that are known to reduce the ability to think in an efficient manner and bring down brain health. These signs are:

- Loss of memory, especially short-term.

- Poor judgment and judgment ability

- Failure in recognizing people or places familiar once.

- Failure in the process of reading, writing or processing numbers

- Anxiety, agitation, or mood changes.

- Disorganized thoughts or confusion

- Lack of impulse control

As the disease advances, patients may be afflicted with severe complications including an inability to swallow or control their bodily functions. In the final stages, most patients die from fatal complications such as aspiration pneumonia.

Causes of Type 3 Diabetes

This may not be well understood with regards to type 3 diabetes, or the exact link between insulin resistance and Alzheimer's disease. Some identified contributing factors include the following:

1. Insulin Resistance

Insulin acts as an important regulatory mechanism of brain functions such as memory and cognition. The reduction in insulin signaling may impair metabolism of brain cells, thus bringing about neurodegeneration.

2. Type 2 Diabetes

These diseases show a strong relationship and those individuals diagnosed with type 2 diabetes have double chances of getting Alzheimer's. In the two, the main causes can be chronic inflammation, oxidative stress, and a defect in glucose metabolism.

3. Environmental and Lifestyle Factors

Insulin resistance associated with obesity, stress, and an unhealthy diet is considered a cause that may increase the chances of Alzheimer's disease.

Researches in Frontiers in Neuroscience and The Lancet Neurology have also highlighted that drugs used for antidiabetic medication may be crucial for the prevention or at least slowing down the course of Alzheimer's.

Treatments for Type 3 Diabetes

In 2022, in a study in Pharmaceuticals, researchers studied biomarker uptake in brain regions implicated in the faulty uptake and metabolism of blood sugar in Alzheimer’s patients.

Emerging Therapies

Research into such treatments as intranasal insulin has also been promising. Intranasal delivery of insulin directly to the brain has been reported to enhance glucose uptake by brain cells, improve memory, and boost cognitive performance. While such clinical trials have been shown to be successful, additional research is needed for safety and efficacy.

Medications

For patients being aggressive or agitated, antipsychotic drugs may be prescribed; however, therapies such as cognitive rehabilitation as well as cognitive stimulation therapy serve to preserve memory and executive function.

Lifestyle Interventions

Diet, exercise, and stress management are critical in preventing and managing insulin resistance. A review in the Journal of Alzheimer's Disease also highlighted the benefits of Kirtan Kriya meditation, which can regulate genes involved in insulin and glucose metabolism, improve sleep, and reduce inflammation.

Can Type 3 Diabetes Be Prevented?

Although type 3 diabetes is not officially recognized, its connection to Alzheimer’s disease underscores the importance of proactive measures for brain health. Some prevention strategies include:

1. Healthy Diet

Consuming a balanced diet rich in antioxidants, whole grains, and healthy fats may support brain health.

2. Regular Exercise

Physical activity improves insulin sensitivity, reduces inflammation, and enhances overall metabolic health.

3. Stress Reduction

Mindfulness practices, including meditation, have been shown to lower stress levels, which can reduce the risk of cognitive decline.

The term type 3 diabetes brings out the complex relationship between metabolic disorders and brain health. Even though it is not a recognized medical condition, the concept emphasizes the crucial role of insulin in brain function and its possible contribution to Alzheimer's disease. Continued research will hopefully provide hope for therapies such as intranasal insulin and lifestyle modifications.

Lung cancer is among one of the most feared health condition known to man and detecting it early on can make a difference between life and death but now a new study has even claiming of a more promising detection option where the detection the disease will be possible even before it starts to grow in this way the potential patient will be able to stay through screening and possible medication far before the ailment starts to grow in their body.

A new study by Australia’s Walter and Eliza Hall Institute of Medical Research (WEHI) has identified a new blood signature that might detect cancer even before the disease develops. They are claiming that with this blood test, there is a chance that detection can be possible even 5 years before it actually occurs. The study was published in Cell.

The research was conducted with over 48,000 blood samples, and they identified a 14-protein signature that predicted lung cancer risk within five years and was validated across eight international datasets. Researchers made clear that the detection did not come from the tumor but from a different inflammatory lung environment that precedes cancer.

WEHI laboratory head Clare Weeden, a corresponding author on the paper, said: "The study could lead to more inclusive and effective screening approaches for people in Australia and across the world." She added, “In doing so, these findings bring us closer to a future where early intervention is possible, even before the cancer has a chance to develop.”

Also Read: Diphtheria Outbreak: Australia Reports First Death In A Decade

What Is Lung Cancer?

Lung Cancer is one of the most common and serious types of cancer. It is also the leading cause of cancer-related deaths worldwide, with approximately 2.5 million new cases and 1.8 million deaths reported in 2022. According to the American Cancer Society, lung cancer mainly occurs in older people. Most people diagnosed with lung cancer are 65 or older; a very small number of people diagnosed are younger than 45.

The Two Main Types Of Lung Cancers Are:

Non-small-cell lung cancer (NSCLC): This is the most common form, making up about 80–85% of all cases. NSCLC includes three subtypes:

• Squamous cell carcinoma
• Adenocarcinoma
• Large-cell carcinoma

Small-cell lung cancer (SCLC): Less common than NSCLC, this type tends to grow and spread more quickly.

Early Signs And Symptoms To Look Out For

Lung cancer symptoms can mimic less serious conditions, which is why they’re often dismissed or misdiagnosed. If you experience the following symptoms persistently, don’t ignore them—regardless of your age or smoking history:

• Chest pain or discomfort
• Unexplained shortness of breath
• Persistent cough or wheezing
• Shoulder, back, or rib pain
• Fatigue or sudden weight loss
• Blood in sputum (though not always present).

For many young and middle- aged adults, headaches or brief dizzy spells often feel routine — attributed to long work hours, stress, or poor sleep. Occasional blackouts or “spacing out” episodes may be brushed aside as fatigue or skipped meals.

What makes these symptoms particularly dangerous is that they are often mistaken for burnout, stress, migraines, or exhaustion — especially among younger working professionals. While most headaches are harmless, persistent neurological symptoms that disrupt daily life should never be ignored.

But there are neurological symptoms you should never ignore: sudden seizures, memory loss after brief collapse, repeated headaches, unexplained weakness, or changes in personality. These can sometimes point to an underlying brain disorder — and, in rare cases, to Glioblastoma, one of the most aggressive forms of brain cancer.

Glioblastoma (GBM) is one of the most aggressive and fast-growing forms of brain cancer in adults. It develops in the supportive tissue of the brain and can quickly affect memory, speech, movement, personality, and other neurological functions. Because the tumour tends to spread into nearby healthy brain tissue, complete surgical removal is often difficult, making timely diagnosis and treatment extremely important. While brain tumours are often associated with older adults, specialists are increasingly seeing younger individuals dismiss early warning signs as work-related fatigue, lack of sleep, stress, or lifestyle burnout. Delayed recognition can sometimes postpone critical medical intervention. In India, there are around 23,000 glioblastoma cases per day, considered higher incidence rates along with North America, Australia, Northern and Eastern Europe. Seizures and persistent headaches are often among the earliest symptoms that prompt medical investigation.

Recently, a 34-year-old woman presented to Apollo Hospitals, Bannerghatta with seizures and memory loss. Her first seizure occurred one morning at home — she collapsed briefly, with twisting of arms and legs, and woke with total memory loss of the episode. Like many young professionals struggling between work and personal commitments, she first considered the cause to be work-induced stress. The family did not suspect that these seemingly routine headaches and blackouts could indicate a serious neurological condition. Before that, she had minor headaches — the kind most people ignore. An MRI scan revealed brain swelling, and anti-seizure medication was prescribed. A second opinion at month’s end showed swelling reduction.

The turning point came in late, during a road trip, when she suffered three seizures in two hours. A burr hole biopsy of a right frontal lesion suggested a diffuse low-grade glioma. Subsequent evaluations at Apollo Hospitals upgraded the diagnosis to bifrontal Glioblastoma — a clinically challenging case due to its location. This is a clinically unusual case because most of the time, GBM is diagnosed with MRI with contrast, MR spectroscopy, and biopsy to confirm the type and grade of tumor. In this patient’s case, imaging revealed widespread bifrontal involvement — making conventional surgery high risk. Her care team opted for a non-surgical precision radiotherapy approach. She had 25 high precision image guided radiotherapy (IGRT) sessions using RapidArc technology. This was followed by two CyberKnife boost sessions to high-risk tumour areas - a plan to boost treatment precisely where it was most needed. All sessions went smoothly, with no major side effects. Since October 2024, she has been undergoing her cycle of monthly chemotherapy treatment alongside her regular scanning.Happily, she was also able to slowly get back to work, engage in recreational activities, and gain a semblance of normal life despite the ongoing cancer treatment.

Signs that point to headaches along with seizures, vomiting, blurred vision, confusion, personality changes, weakness, or an increasing frequency of symptoms should be evaluated medically without delay. Even one seizure is not an issue to ignore.

Some symptoms you must mention to your doctor will be:

• Dizziness or headaches

• Constriction
• Trembling and weakness or paralysis
• Memory loss or other indications of memory disorder
• Visual difficulties

It may help you diagnose your problems effectively if you see a neurologist, conduct MRI brain imaging and have consultations from an early stage. While some headaches or seizures do not necessarily mean having a tumor in the brain, regular occurrence of such symptoms with no reason is likely to be examined by an expert. However, although a proper healthy lifestyle may help your brain remain healthy, it will be ineffective for illnesses like GBM.

Dr Sridhar PS, Radiation Oncologist, Apollo Hospitals, Bangalore

Glomerular Diseases affect the glomeruli, which are very small filtering units in the human kidney, and when they get damaged due to disorders, the filters leak blood and vital proteins into the urine and fail to remove waste efficiently. Eventually, these problems can lead to chronic kidney disease or kidney failure. As per its treatment, medications are used to slow kidney damage, manage blood pressure, and reduce protein leakage.

Notably, a new study has revealed hope in this condition by finding that a well-known drug can be very effective in slowing damage if the patient has Glomerular Diseases, and that common drug is Finerenone, which is often prescribed for heart and kidney diseases associated with type 2 diabetes.

The trial was participated in by 903 participants with glomerular diseases. The drug finerenone was given to them. The results show that compared with placebo, it slowed kidney damage, reduced albuminuria, and lowered the risk of kidney failure or sustained loss of kidney function.

Thus, the study clearly indicates that the drug called finerenone may play an important role in protecting kidney function in patients with glomerular diseases.

The research was conducted through subgroup analysis of a phase 3, randomized, double-blind, placebo-controlled trial conducted across 24 countries and regions, focusing on participants with an investigator-reported glomerular disease.

The study was conducted on a large scale, having conducted the research for months in 24 countries and regions. The trial also took care of other important details and implemented all required paperwork, thus securing approvals by regulatory authorities along with ethics committees in every center. Other than that, the participants were required to submit written informed consent. Moreover, an independent data monitoring committee performed safety monitoring throughout the tests.

How To Keep Kidneys Healthy?

Dietary habits can contribute to kidney strain, particularly when busy schedules encourage reliance on convenient foods that are often high in sodium and low in nutritional value.

Hydration habits are additional concerns among office workers. Many professionals rely heavily on coffee, energy drinks, or sugary beverages during long workdays, often replacing plain water as the main source of fluid intake.

Protecting kidney health often begins with small lifestyle changes. Reducing processed food consumption, limiting excessive salt intake, staying adequately hydrated, and maintaining regular sleep schedules can all support kidney function.

Taking short movement breaks during long work hours and managing stress through regular physical activity or relaxation techniques may also help reduce the long-term strain that modern work routines place on the body.