What Is Type 3 Diabetes? Insulin Resistance In The Brain That Could Trigger Alzheimer’s
Most people are aware of type 1 and type 2 diabetes, but did you know there is a type 3 diabetes as well! It is a more obscure term. Although it is not an accepted medical diagnosis, type 3 diabetes has been discussed in the literature as a possible relationship between insulin resistance in the brain and Alzheimer's disease. This link has been described to help explain how metabolic disorders impact brain health, causing cognitive decline and dementia.
Type 3 diabetes is more of a misnomer because it should not be confused with type 3c diabetes, which relates to pancreatic dysfunction. The term "type 3 diabetes," on the other hand, has been loosely used by some scientists to analogously propose that Alzheimer's disease is strongly implicated with insulin resistance in the brain.
This concept was conceptualized by Dr. Suzanne de la Monte and Dr. Jack Wands of Brown University in the year 2008. This hypothesis postulated that Alzheimer's disease may be called type 3 diabetes for it bears many similarities with glucose metabolism disorder type 2 diabetes. Their concept arises from the basic principle that insulin is fundamental to blood sugar regulation, but it is also the case with the brain. When brain cells become insulin-resistant, they lose access to glucose, impairing their function.
Research published in the Journal of Diabetes Science and Technology supports this hypothesis by indicating that insulin resistance can be a significant contributor to the occurrence of dementia, also referred to as Alzheimer's. The symptoms of memory loss and diminished reasoning are associated with impaired glucose metabolism in the body, especially in the cerebral tissue.
Although type 3 diabetes is not a "medical term," its symptoms correlate well with Alzheimer's diseases that are known to reduce the ability to think in an efficient manner and bring down brain health. These signs are:
- Loss of memory, especially short-term.
- Poor judgment and judgment ability
- Failure in recognizing people or places familiar once.
- Failure in the process of reading, writing or processing numbers
- Anxiety, agitation, or mood changes.
- Disorganized thoughts or confusion
- Lack of impulse control
As the disease advances, patients may be afflicted with severe complications including an inability to swallow or control their bodily functions. In the final stages, most patients die from fatal complications such as aspiration pneumonia.
This may not be well understood with regards to type 3 diabetes, or the exact link between insulin resistance and Alzheimer's disease. Some identified contributing factors include the following:
Insulin acts as an important regulatory mechanism of brain functions such as memory and cognition. The reduction in insulin signaling may impair metabolism of brain cells, thus bringing about neurodegeneration.
These diseases show a strong relationship and those individuals diagnosed with type 2 diabetes have double chances of getting Alzheimer's. In the two, the main causes can be chronic inflammation, oxidative stress, and a defect in glucose metabolism.
Insulin resistance associated with obesity, stress, and an unhealthy diet is considered a cause that may increase the chances of Alzheimer's disease.
Researches in Frontiers in Neuroscience and The Lancet Neurology have also highlighted that drugs used for antidiabetic medication may be crucial for the prevention or at least slowing down the course of Alzheimer's.
In 2022, in a study in Pharmaceuticals, researchers studied biomarker uptake in brain regions implicated in the faulty uptake and metabolism of blood sugar in Alzheimer’s patients.
Emerging Therapies
Research into such treatments as intranasal insulin has also been promising. Intranasal delivery of insulin directly to the brain has been reported to enhance glucose uptake by brain cells, improve memory, and boost cognitive performance. While such clinical trials have been shown to be successful, additional research is needed for safety and efficacy.
Medications
For patients being aggressive or agitated, antipsychotic drugs may be prescribed; however, therapies such as cognitive rehabilitation as well as cognitive stimulation therapy serve to preserve memory and executive function.
Lifestyle Interventions
Diet, exercise, and stress management are critical in preventing and managing insulin resistance. A review in the Journal of Alzheimer's Disease also highlighted the benefits of Kirtan Kriya meditation, which can regulate genes involved in insulin and glucose metabolism, improve sleep, and reduce inflammation.
Although type 3 diabetes is not officially recognized, its connection to Alzheimer’s disease underscores the importance of proactive measures for brain health. Some prevention strategies include:
1. Healthy Diet
Consuming a balanced diet rich in antioxidants, whole grains, and healthy fats may support brain health.
2. Regular Exercise
Physical activity improves insulin sensitivity, reduces inflammation, and enhances overall metabolic health.
3. Stress Reduction
Mindfulness practices, including meditation, have been shown to lower stress levels, which can reduce the risk of cognitive decline.
The term type 3 diabetes brings out the complex relationship between metabolic disorders and brain health. Even though it is not a recognized medical condition, the concept emphasizes the crucial role of insulin in brain function and its possible contribution to Alzheimer's disease. Continued research will hopefully provide hope for therapies such as intranasal insulin and lifestyle modifications.
Credit: iStock
The first 1,000 days, right from pregnancy until a child's second birthday, are a crucial window for growth and brain development. Hence, understand that breastfeeding during this period plays a key role in building lifelong health and immunity for the child. Read on to know more about how breastfeeding tends to shape the child’s health for life.
The first 1,000 days of a child's life, right from conception until the age of two years, is often a critical time for growth and development. During this time, brain development happens rapidly, organs mature, and even the immune system tends to become stronger.
Good nutrition tends to have a huge impact on the child’s physical health, learning ability, and even overall well-being. Breastfeeding helps the baby to get enough nutrition. Breast milk also protects babies from infections and tends to support healthy growth.
Also read: Breastfeeding Moms Are Mixing Formula & Breast Milk-Should You?
Breastfeeding involves a correct balance of proteins, healthy fats, vitamins, minerals, and antibodies that a growing baby needs. Breastfeeding strengthens the baby's immune system. Babies who are breastfed will be able to prevent diarrhoea, ear infections, and respiratory illnesses.
Important nutrients such as DHA and other healthy fats help in the growth of the brain and nervous system, which may improve learning and cognitive development later in life. Did you know? Breastfeeding is important and even helps to reduce the chances of obesity, type 2 diabetes, and certain allergies as children grow older.
It encourages healthy weight gain during infancy and helps develop better eating habits. Breastfeeding is also beneficial for mothers. It helps the uterus return to its normal size after childbirth, reduces bleeding after delivery, and may lower the risk of breast and ovarian cancers. Breastfeeding creates a strong emotional bond with their baby through close skin-to-skin contact.
Also read: Breastfeeding Week: Experts Share How Breastfeeding Helps You and Your Child?
Hence, follow these tips and ensure proper breastfeeding for the child.
By Dr Nishant Bansal, Consultant - Paediatrician & Neonatologist, Motherhood Hospitals, Noida
Credit: AI
Patient should not be afraid to ask what type of lung cancer, Stage and spread of disease whether it has spread and what is stage of disease, This information helps direct treatment decisions and provides insight into the future prospective of disease status .
The patient should self designate a Trustee who will take care of her Medical Records , fixing up appointment and be responsible for medication administration. A diagnosis of lung cancer can be shocking and worrisome, but knowing what to expect can help patients make more informed choices.
The first lesson is that lung cancer can be very different from patient to patient. Treatment depends on the type, stage as well as genetic changes and health.
For lung cancer patients some patients will require testing the tumour for specific Molecular markers which help in deciding type of immunotherapy . Before beginning treatment, patients should be asked for if they have had the appropriate tests done for fitness before therapy.
Modern lung cancer care may involve surgery, radiation therapy, chemotherapy, targeted medicines and immunotherapy, often in various combinations. The best treatment will depend on the type of cancer and the health of the patient.
Also read: What Is Driving India's High Burden Of Childhood Cancers?
Patients should not quietly accept worsening shortness of breath, pain, fever, severe weakness, poor appetite or side effects of treatment. Early communication can assist doctors in managing complications and maintaining quality of life.
Palliative or supportive care is not just for the end of the cancer course. It can be given along with cancer treatment to help manage symptoms, improve emotional wellbeing and increase everyday comfort.
Above all, I do not think that a diagnosis means there are no options. The treatment of lung cancer is changing rapidly and the results can vary greatly from patient to patient. Ask questions, clarify, and understand treatment plan and when appropriate, get a second opinion before making major decisions.
Credit: WHO
Breastfeeding is important not only for babies' health and nutrition but also for protecting mothers from serious diseases, the World Health Organization (WHO) said.
It urged governments to strengthen access to services and interventions that support breastfeeding as part of World Breastfeeding Week, observed annually from August 1–7.
The 2026 theme, "Breastfeeding for a Sustainable Start in Life: Strengthen What Works," focuses on tracking progress, evaluating impact, and scaling proven approaches that improve breastfeeding outcomes.
"Scaling up breastfeeding could prevent almost 400,000 child deaths and around 140,000 maternal deaths each year," said UNICEF Executive Director Catherine Russell and WHO Director-General Dr. Tedros Adhanom Ghebreyesus in a joint statement.
"Every US$1 invested in breastfeeding promotion generates an estimated US$59 in economic returns through lower health-care costs, improved cognitive development, higher educational attainment, and increased lifetime earnings," they added.
The experts noted that breastfeeding is one of the simplest and most powerful ways to protect a child's health. It provides infants and young children with essential nutrition, boosts immunity, helps protect against serious illnesses, and supports cognitive development.
For mothers, breastfeeding also offers significant health benefits by reducing the risk of noncommunicable diseases such as breast and ovarian cancers, and type 2 diabetes.
The WHO said breastfeeding rates have improved globally due to sustained investments in policies and programs supporting mothers and families.
Exclusive breastfeeding during the first six months increased from around 37 per cent in 2012 to more than 47 per cent today. Over the past five years, the prevalence of breastfeeding up to two years of age has risen from 38 per cent to 50 per cent.
Despite these gains, the WHO said many countries continue to lag behind global targets.
"Coverage of services supporting breastfeeding remains low, policies are inconsistently enforced, and service quality is often inadequate, especially in low-income, fragile, and humanitarian settings," the WHO said.
The agency noted that cost-effective interventions include skilled breastfeeding support within health systems, community-based counselling, maternity protection policies, and protection from the exploitative marketing of commercial milk formulas.
WHO and UNICEF called on governments, health systems, workplaces, communities, civil society organizations, and families to strengthen the "Warm Chain of Support" for breastfeeding.
During World Breastfeeding Week, the agencies urged countries to:
"Breastfeeding is vital. By investing in proven solutions, we can give every child the best possible start in life and ensure every mother gets the care and services she needs," the agencies said.
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