Most people are aware of type 1 and type 2 diabetes, but did you know there is a type 3 diabetes as well! It is a more obscure term. Although it is not an accepted medical diagnosis, type 3 diabetes has been discussed in the literature as a possible relationship between insulin resistance in the brain and Alzheimer's disease. This link has been described to help explain how metabolic disorders impact brain health, causing cognitive decline and dementia.

What is Type 3 Diabetes?

Type 3 diabetes is more of a misnomer because it should not be confused with type 3c diabetes, which relates to pancreatic dysfunction. The term "type 3 diabetes," on the other hand, has been loosely used by some scientists to analogously propose that Alzheimer's disease is strongly implicated with insulin resistance in the brain.

This concept was conceptualized by Dr. Suzanne de la Monte and Dr. Jack Wands of Brown University in the year 2008. This hypothesis postulated that Alzheimer's disease may be called type 3 diabetes for it bears many similarities with glucose metabolism disorder type 2 diabetes. Their concept arises from the basic principle that insulin is fundamental to blood sugar regulation, but it is also the case with the brain. When brain cells become insulin-resistant, they lose access to glucose, impairing their function.

Research published in the Journal of Diabetes Science and Technology supports this hypothesis by indicating that insulin resistance can be a significant contributor to the occurrence of dementia, also referred to as Alzheimer's. The symptoms of memory loss and diminished reasoning are associated with impaired glucose metabolism in the body, especially in the cerebral tissue.

Symptoms of Type 3 Diabetes

Although type 3 diabetes is not a "medical term," its symptoms correlate well with Alzheimer's diseases that are known to reduce the ability to think in an efficient manner and bring down brain health. These signs are:

- Loss of memory, especially short-term.

- Poor judgment and judgment ability

- Failure in recognizing people or places familiar once.

- Failure in the process of reading, writing or processing numbers

- Anxiety, agitation, or mood changes.

- Disorganized thoughts or confusion

- Lack of impulse control

As the disease advances, patients may be afflicted with severe complications including an inability to swallow or control their bodily functions. In the final stages, most patients die from fatal complications such as aspiration pneumonia.

Causes of Type 3 Diabetes

This may not be well understood with regards to type 3 diabetes, or the exact link between insulin resistance and Alzheimer's disease. Some identified contributing factors include the following:

1. Insulin Resistance

Insulin acts as an important regulatory mechanism of brain functions such as memory and cognition. The reduction in insulin signaling may impair metabolism of brain cells, thus bringing about neurodegeneration.

2. Type 2 Diabetes

These diseases show a strong relationship and those individuals diagnosed with type 2 diabetes have double chances of getting Alzheimer's. In the two, the main causes can be chronic inflammation, oxidative stress, and a defect in glucose metabolism.

3. Environmental and Lifestyle Factors

Insulin resistance associated with obesity, stress, and an unhealthy diet is considered a cause that may increase the chances of Alzheimer's disease.

Researches in Frontiers in Neuroscience and The Lancet Neurology have also highlighted that drugs used for antidiabetic medication may be crucial for the prevention or at least slowing down the course of Alzheimer's.

Treatments for Type 3 Diabetes

In 2022, in a study in Pharmaceuticals, researchers studied biomarker uptake in brain regions implicated in the faulty uptake and metabolism of blood sugar in Alzheimer’s patients.

Emerging Therapies

Research into such treatments as intranasal insulin has also been promising. Intranasal delivery of insulin directly to the brain has been reported to enhance glucose uptake by brain cells, improve memory, and boost cognitive performance. While such clinical trials have been shown to be successful, additional research is needed for safety and efficacy.

Medications

For patients being aggressive or agitated, antipsychotic drugs may be prescribed; however, therapies such as cognitive rehabilitation as well as cognitive stimulation therapy serve to preserve memory and executive function.

Lifestyle Interventions

Diet, exercise, and stress management are critical in preventing and managing insulin resistance. A review in the Journal of Alzheimer's Disease also highlighted the benefits of Kirtan Kriya meditation, which can regulate genes involved in insulin and glucose metabolism, improve sleep, and reduce inflammation.

Can Type 3 Diabetes Be Prevented?

Although type 3 diabetes is not officially recognized, its connection to Alzheimer’s disease underscores the importance of proactive measures for brain health. Some prevention strategies include:

1. Healthy Diet

Consuming a balanced diet rich in antioxidants, whole grains, and healthy fats may support brain health.

2. Regular Exercise

Physical activity improves insulin sensitivity, reduces inflammation, and enhances overall metabolic health.

3. Stress Reduction

Mindfulness practices, including meditation, have been shown to lower stress levels, which can reduce the risk of cognitive decline.

The term type 3 diabetes brings out the complex relationship between metabolic disorders and brain health. Even though it is not a recognized medical condition, the concept emphasizes the crucial role of insulin in brain function and its possible contribution to Alzheimer's disease. Continued research will hopefully provide hope for therapies such as intranasal insulin and lifestyle modifications.

The U-WIN (Universal Immunization Win) platform has been transformative and has helped India tackle the concerning burden of zero-dose children, said Dr NK Arora, an immunization expert and member of the National Technical Advisory Group on Immunisation in India (NTAGI).

In an exclusive conversation with HealthandMe during World Immunization Week 2026, Dr Arora, Executive Director of The INCLEN Trust International, traced the journey of the U-WIN portal and explained how it has strengthened vaccine uptake in the country.

U-WIN is a digital platform and app to help people find vaccination centers near their residences, manage vaccination appointments at health facilities, and maintain vaccination records.

Dr Arora noted that the U-WIN portal created a digital ecosystem that played a critical role in registration, appointment scheduling, vaccine tracking, and real-time monitoring.

The Origin Of U-WIN

U-Win was launched in October 2024 and is available in 12 languages, including English.

Dr Arora, also the chair of the COVID-19 and HPV vaccine working group, shared that during the deadly COVID pandemic in 2020—around July—it became very clear that to vaccinate 140 crore people, some kind of IT platform is needed that will track individuals who had been vaccinated, especially when they needed their second dose, and later, booster doses.

“Everything started somewhere around July 2020, and by January 2021, we had the Co-WIN platform. By mid-April, things were streamlined. The platform gives us a long list of individuals who have been vaccinated. It also helps to know who has been left out of the vaccination.

“It is like a registry of human beings who are getting immunized. And we could send reminders, we could send certificates, and we can also tell the individual when to get their second and third dose,” the expert said.

He noted that as COVID became less intense toward the end of 2021, serious discussions began on using the same platform for routine immunization. This is where the concept of U-WIN came in 2022. It has now been piloted and is gradually being used.

U-WIN: Closing the Gap For Missed and Zero-Dose Children

The UWIN now has the mechanism to ensure that immunization is completed for everyone who registers. One user can register up to 10 people in one mobile number, including citizens/guardians, pregnant women, infants (0-1 years), children (1-7 years), and adolescents (7-19 years).

“The key issue is that tracking provides two or three important inputs. First, it ensures that everyone is getting vaccinated and that it is not dependent on memory. There is a proper record—whether a person or child has received vaccines and what their current status is, including whether the schedule is complete,” Dr Arora said.

“Second, one of the main reasons for missing or delaying the next dose was that mothers often did not remember. Fathers contributed very little to this process, but they also became involved because of the reminder system,” he added.

Another important role of U-WIN is tackling the so-called zero-dose children—those who have never been vaccinated.

“About 4–5 per cent of our eligible population falls into this category, meaning they have not received even the first pentavalent dose. On the face of it, 4–5 per cent may not seem like a huge problem. But when we look at the absolute numbers—out of 26 million—it translates into a very large number, which we cannot afford to miss. So tracking helps identify these children through the micro-plan system”.

U-WIN Enables Life-course Immunization

Also read: World Immunization Week: Vaccines Are Like Insurance, They’re Safe—Take Them, Says Dr NK Arora

“When a child is vaccinated, we know when boosters are due—at one and a half years, then at five years. But none of us remembers this. Even among well-informed parents, this is often forgotten. This system helps address that gap,” Dr. Arora said.

Further, when the same individual becomes eligible for vaccines like HPV—typically between 9 and 14 years—there is again a gap that needs to be addressed.

Certification is another benefit, as it creates a documented process, particularly for programs like oral polio vaccination.

Dr. Arora highlighted that in case of any future pandemic-like situation that requires repeated vaccinations, “we have a mechanism in place”.

“This IT platform has truly transformed the system. There is also a lot of discussion about using similar platforms for TB patients, pregnant women, and other flagship programs like non-communicable diseases. So, for India, digitalisation is at its best when we talk about U-WIN.”

Summer can invite a plethora of health problems in children. Moreover, dehydration is commonly seen when the body loses more fluids than it takes in. It is important to understand that early or subclinical dehydration can present as fatigue, irritability and reduced appetite, often going unnoticed by parents. Hence, parents need to detect the signs and symptoms of dehydration in children and seek timely help. Parents should follow the vital measures suggested by experts and safeguard their well-being.

Are children more prone to dehydration in a heatwave?

Dr Tushar Parikh, Senior Consultant Neonatologist and Head of Department at Motherhood Hospital, Kharadi, Pune, in an interaction with Health and Me, spoke about dehydration in children and how parents can identify it promptly.

“As temperatures rise during the summer months, dehydration becomes a common yet often overlooked problem in children. Dehydration occurs when the body does not have enough fluids to function properly. The causes can include inadequate fluid intake, sweating, prolonged outdoor play, and illnesses such as fever, vomiting and diarrhoea,” Dr Parikh explained.

Children are at a greater risk of dehydration as fluid loss occurs quickly through sweat. Severe dehydration is easier to identify, but early or ‘subclinical’ dehydration often goes unnoticed, silently affecting a child’s health and behaviour. Parents may assume that their child is simply tired or irritable due to the heat, but these could be early warning signs of fluid imbalance. Dehydration is often the last thing that comes to mind. However, it is frequently considered a minor issue in children. Subclinical dehydration refers to mild fluid loss that does not show obvious signs, such as extreme thirst, but still affects the body.

What are the symptoms of dehydration in children?

Dr Parikh stated that many children exhibit symptoms such as tiredness, irritability and poor appetite. They may also complain of headaches, feel dizzy, or show reduced concentration while studying. Another important sign is decreased urination or darker urine, which often goes unnoticed. Over time, if not addressed, this mild dehydration can impact energy levels and mood, and may become severe, requiring hospital admission. Hence, parents must take charge of their child’s health and seek timely attention even for mild dehydration.

How can parents help children when they are dehydrated?

Dr Parikh shared some simple tips that can help beat dehydration in childre. The expert said that dehydration can be prevented in children by encouraging them to drink water regularly. Children should ideally consume at least 2–3 litres of water daily, along with coconut water, buttermilk and fresh fruit juices to stay hydrated. Parents can also include foods such as watermelon, oranges and cucumbers, which help maintain hydration. It is advisable to limit junk, oily, canned and processed foods. Children should avoid playing outdoors during peak heat hours. Parents should dress their children in light, loose cotton clothing, which helps reduce sweating. Monitoring urine colour and frequency can be a simple way to assess a child’s hydration status. Parents should adhere to these tips to prevent dehydration in children.

Do you see your elderly loved ones pausing and quietly struggling every time they eat? In many households, a slight difficulty in swallowing—known as dysphagia—is often brushed aside as normal ageing or eating too fast.

Speaking to HealthandMe, doctors warned that this seemingly harmless symptom should not be ignored, as it could be cancer of the esophagus.

"When food repeatedly feels stuck in the chest, or swallowing becomes difficult, it may not be ageing at all. It could be an early warning sign of a serious condition, including esophageal cancer," said Dr. Surender Kumar Dabas, Chairman - Manipal Comprehensive Cancer Centre and Onco Robotic Surgeries, Manipal Hospital.

Esophageal cancer is a growth of cells that starts in the esophagus. The esophagus is a long, hollow tube that helps move swallowed food from the back of the throat to the stomach for digestion.

"Esophageal cancer typically remains silent during its initial phases, and the inability to swallow is one of the most typical warning signs. With the expansion of the tumor, the food pipe has the potential to get narrowed, which obstructs the smooth passage of food into the stomach. In case an individual constantly feels that something gets stuck in the mouth, one has to see a doctor and have a proper examination," added Dr. Hemkant Verma, Consultant - Surgical Oncology, ShardaCare-Healthcity.

Warning Signs That Many Ignore

Also read:This Man Made 24 Doctor Visits for Back and Leg Pain, Died 12 Days After Cancer Diagnosis

Although difficulty swallowing is usually the first sign people notice, the body sends out other quite signals too. This includes:

• Food sticking in the chest or throat: A sensation that food is not going down smoothly and feels stuck after swallowing, especially with solid foods.

• Gradual difficulty in swallowing: Initially struggling with solids like roti or rice, and gradually facing difficulty even with semi-solids or liquids.

• Frequent choking or coughing while eating: This may indicate that food is entering the airway instead of the esophagus

• Unintentional weight loss: Dropping weight without even trying, mostly because eating has started to feel like a difficult chore.

• Chest pain: A persistent discomfort behind the breastbone that is not relieved with an antacid

• Vomiting or coughing up blood: A serious sign that the lining of the food pipe is irritated or damaged and needs immediate attention.

Treatment For Esophageal Cancer

Esophageal cancer is a malignant tumor in the food pipe, and primarily affects people over the age of 55.

The doctors also warned of lifestyle choices that may predispose one to esophageal cancer. This includes tobacco use, alcohol consumption, chronic acid reflux, obesity, and bad diet choices.

While early diagnosis is quite important to enhance the success of treatment, patients often tend to postpone seeking medical treatment for such symptoms, resulting in late diagnosis and poor outcomes.

Read more: Suffering From Mid-back Pain? Doctors Say It May Be Spinal TB

The first step in diagnosis is usually an endoscopy, where a camera is used to check for any unusual growths. If a tumor is found, a biopsy is taken.

Upon biopsy confirmation, a staging workup is required, usually in the form of a PET-CT scan.

Treatment typically involves a multidisciplinary approach consisting of radiation and chemotherapy followed by surgery. The surgery is known as esophagectomy, where the diseased part of the tube is removed, and the remaining part is reconnected to the stomach. If detected early and treated properly, the disease is curable.