What Is Type 3 Diabetes? Insulin Resistance In The Brain That Could Trigger Alzheimer’s
Most people are aware of type 1 and type 2 diabetes, but did you know there is a type 3 diabetes as well! It is a more obscure term. Although it is not an accepted medical diagnosis, type 3 diabetes has been discussed in the literature as a possible relationship between insulin resistance in the brain and Alzheimer's disease. This link has been described to help explain how metabolic disorders impact brain health, causing cognitive decline and dementia.
Type 3 diabetes is more of a misnomer because it should not be confused with type 3c diabetes, which relates to pancreatic dysfunction. The term "type 3 diabetes," on the other hand, has been loosely used by some scientists to analogously propose that Alzheimer's disease is strongly implicated with insulin resistance in the brain.
This concept was conceptualized by Dr. Suzanne de la Monte and Dr. Jack Wands of Brown University in the year 2008. This hypothesis postulated that Alzheimer's disease may be called type 3 diabetes for it bears many similarities with glucose metabolism disorder type 2 diabetes. Their concept arises from the basic principle that insulin is fundamental to blood sugar regulation, but it is also the case with the brain. When brain cells become insulin-resistant, they lose access to glucose, impairing their function.
Research published in the Journal of Diabetes Science and Technology supports this hypothesis by indicating that insulin resistance can be a significant contributor to the occurrence of dementia, also referred to as Alzheimer's. The symptoms of memory loss and diminished reasoning are associated with impaired glucose metabolism in the body, especially in the cerebral tissue.
Although type 3 diabetes is not a "medical term," its symptoms correlate well with Alzheimer's diseases that are known to reduce the ability to think in an efficient manner and bring down brain health. These signs are:
- Loss of memory, especially short-term.
- Poor judgment and judgment ability
- Failure in recognizing people or places familiar once.
- Failure in the process of reading, writing or processing numbers
- Anxiety, agitation, or mood changes.
- Disorganized thoughts or confusion
- Lack of impulse control
As the disease advances, patients may be afflicted with severe complications including an inability to swallow or control their bodily functions. In the final stages, most patients die from fatal complications such as aspiration pneumonia.
This may not be well understood with regards to type 3 diabetes, or the exact link between insulin resistance and Alzheimer's disease. Some identified contributing factors include the following:
Insulin acts as an important regulatory mechanism of brain functions such as memory and cognition. The reduction in insulin signaling may impair metabolism of brain cells, thus bringing about neurodegeneration.
These diseases show a strong relationship and those individuals diagnosed with type 2 diabetes have double chances of getting Alzheimer's. In the two, the main causes can be chronic inflammation, oxidative stress, and a defect in glucose metabolism.
Insulin resistance associated with obesity, stress, and an unhealthy diet is considered a cause that may increase the chances of Alzheimer's disease.
Researches in Frontiers in Neuroscience and The Lancet Neurology have also highlighted that drugs used for antidiabetic medication may be crucial for the prevention or at least slowing down the course of Alzheimer's.
In 2022, in a study in Pharmaceuticals, researchers studied biomarker uptake in brain regions implicated in the faulty uptake and metabolism of blood sugar in Alzheimer’s patients.
Emerging Therapies
Research into such treatments as intranasal insulin has also been promising. Intranasal delivery of insulin directly to the brain has been reported to enhance glucose uptake by brain cells, improve memory, and boost cognitive performance. While such clinical trials have been shown to be successful, additional research is needed for safety and efficacy.
Medications
For patients being aggressive or agitated, antipsychotic drugs may be prescribed; however, therapies such as cognitive rehabilitation as well as cognitive stimulation therapy serve to preserve memory and executive function.
Lifestyle Interventions
Diet, exercise, and stress management are critical in preventing and managing insulin resistance. A review in the Journal of Alzheimer's Disease also highlighted the benefits of Kirtan Kriya meditation, which can regulate genes involved in insulin and glucose metabolism, improve sleep, and reduce inflammation.
Although type 3 diabetes is not officially recognized, its connection to Alzheimer’s disease underscores the importance of proactive measures for brain health. Some prevention strategies include:
1. Healthy Diet
Consuming a balanced diet rich in antioxidants, whole grains, and healthy fats may support brain health.
2. Regular Exercise
Physical activity improves insulin sensitivity, reduces inflammation, and enhances overall metabolic health.
3. Stress Reduction
Mindfulness practices, including meditation, have been shown to lower stress levels, which can reduce the risk of cognitive decline.
The term type 3 diabetes brings out the complex relationship between metabolic disorders and brain health. Even though it is not a recognized medical condition, the concept emphasizes the crucial role of insulin in brain function and its possible contribution to Alzheimer's disease. Continued research will hopefully provide hope for therapies such as intranasal insulin and lifestyle modifications.
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India is seeing a steady and worrying rise in breast cancer cases, with numbers nearly doubling over the past ten years in many urban areas. What was once considered a gradual increase has now become much more visible across the country.
Over the last two decades, breast cancer cases have been slowly increasing. But in the last decade, the rise has been sharper. At the same time, there has been a major shift in the type of cancers affecting women. Earlier, cervical cancer was the most common. Today, breast cancer has taken that position across India.
One of the biggest reasons behind this rise is that lifestyles have changed, especially among urban dwellers. Diets are now richer in fats, with physical activities taking a backseat, leading to obesity becoming normal. These factors, along with hormonal changes, delayed pregnancies, and genetic risks, all contribute to a higher chance of developing breast cancer.
At the same time, there is also a more encouraging side to this story. More women today are getting diagnosed earlier than before. A decade ago, many patients would come in with advanced stages of the disease. Now, a larger number are being detected in Stage 1 and Stage 2. This shift is important because early detection significantly improves survival.
Better awareness and easier access to screening have played a big role in this change. Campaigns during Breast Cancer Awareness Month have helped bring conversations around breast cancer into the mainstream. More women are now opting for regular check-ups and mammograms, which means cancers are being caught earlier.
However, the overall numbers still remain a concern. It is estimated that one in every 25 to 28 women in India will develop breast cancer at some point in their lives. When this is applied to the country’s population, it translates into a very large number of women being affected.
The important thing to understand is that this rise is not due to one single reason. It is a mix of lifestyle changes, increased awareness, better detection, and possibly hormonal and environmental factors that are still being studied.
The way forward is clear. Regular screening is one of the most effective tools available today. Women above the age of 40 should ideally undergo a mammogram every year, even if there are no symptoms. Early-stage breast cancer can be treated very effectively, with cure rates going up to nearly 99% when detected at the earliest stage.
While the numbers may seem alarming, there is also a sense of progress. More awareness, better screening, and earlier diagnosis mean that outcomes are improving. The focus now needs to be on making screening a routine habit and encouraging healthier lifestyles.
Breast cancer is on the rise in India, but with the right approach, it is also one of the cancers where early action can make the biggest difference.
Credit: Canva
Magnesium is an essential mineral that plays a crucial role in over 300 biochemical reactions in the body. From regulating muscle and nerve function, to supporting a healthy immune system, to building protein, maintaining blood sugar and blood pressure levels, and aiding in energy production, magnesium plays an important role in our health.
Importantly, it helps in getting a good night’s sleep by promoting relaxation, calming the nervous system, and helping your body produce melatonin, the so-called sleep hormone. Magnesium supplements are among the most popular dietary supplements in America, the Washington Post reported.
“There’s a lot of interest in magnesium right now — all of my patients are asking me about it,” Bethany Marie Doerfler, a clinical research dietitian at the Northwestern Digestive Health Center, was quoted as saying.
“There’s a lot of insomnia in the United States, and many of my patients are saying, ‘Can I use magnesium, can it be helpful?’”
Studies have proven that high levels of magnesium in the diet can lower the risk of heart disease and strokes. It also increases bone mineral density, protecting against fractures and osteoporosis.
Yet despite its well-documented benefits, researchers have found that a majority of people consume less magnesium than the recommended amounts.
According to the American health officials, women aged between 19 and 30 should consume 310 milligrams of magnesium daily (350 milligrams if they’re pregnant), and 320 milligrams if they are 31 or older.
For men, the recommendation is that they consume 400 milligrams if they’re 19 to 30 years old, and 420 milligrams if they’re 31 or older.
Doerfler noted that one can get plenty of magnesium simply by eating a few daily servings of the right plant foods.
According to the National Institutes of Health some top dietary sources of magnesium, include
Most people get enough magnesium from food, but certain groups are more vulnerable to deficiency. These include people with gastrointestinal disorders such as Crohn’s disease or coeliac disease, those with type 2 diabetes, people who consume excessive alcohol, and older adults.
If you’re low on magnesium, you might notice symptoms such as muscle twitches, spasms, fatigue, low appetite, nausea, or an irregular heartbeat. However, the only way to confirm a deficiency is through a blood test prescribed by your doctor.
While magnesium deficiency can lead to cramps, most cases of muscle cramps are not due to low magnesium. Research shows limited evidence that supplements prevent cramps, especially in older adults.
The link between magnesium and better sleep is also unclear. Some studies found it helped people fall asleep faster, while others found no significant difference.
When it comes to migraines, evidence is stronger. Studies suggest that taking 122–600 mg of magnesium daily for 4–24 weeks may reduce the frequency and severity of migraines in some people.
In general, magnesium supplements are safe when taken in the recommended amounts. However, too much can lead to nausea, abdominal cramps, and diarrhea, because magnesium draws water into the intestines.
Taking extremely large doses (around 5,000 mg daily) can cause magnesium toxicity, which is dangerous. Always check with your doctor before starting supplements, especially if you take other medications.
Credit: Daily Mail
A 31-year-old Brazilian beauty queen, Maiara Cristina de Lima Fiel, has reportedly died after suffering a sudden heart attack.
de Lima Fiel, a young mother, was due to compete in a beauty pageant next week. She reportedly had no major health issues. Paramedics spent more than an hour trying to save her life but she tragically did not recover, The Daily Mail reported.
Her untimely death has sparked grief and shock among her community and followers, and has also reignited concerns over unexpected cardiac events in seemingly healthy individuals.
de Lima Fiel was crowned Miss Londrina last year in a prestigious regional beauty pageant and also came runner-up in the 2025/26 edition of Miss Sarandi, The Daily Mail reported.
"She was such a committed, dedicated young woman," the report quoted Vitor Tavares, organizer of the contest Maiara, as saying. She was due to compete on April 29.
"I had the pleasure of meeting her in person at the end of last year when she confirmed her participation as Miss Londrina. From that moment, it was clear how seriously she took this dream," he added.
While detailed medical circumstances have not been publicly disclosed, such sudden cardiac events in young adults are often linked to underlying, sometimes undiagnosed, heart conditions or acute cardiovascular episodes.
Also read: US Cardiologist Explains Why 2026 AHA Cholesterol Guidelines Recommend Starting Young
Acute coronary syndromes, or heart attacks, are on the rise among young adults.
While there are some genetic predispositions for premature heart attacks, the majority of the risk is attributed to the increased incidence of conventional risk factors in young people, such as
Also read: Ideal Blood Pressure Reading for Older Adults: Harvard Health Experts Have an Answer
Doctors are now seeing them in people as young as their late 30s and early 40s, especially those with high-stress jobs.
“They mistake early signs for lifestyle issues: acidity after a heavy dinner, shoulder pain from sitting at a laptop, or tiredness from long hours," Pankaj Vinod Jariwala, Interventional Cardiologist at Yashoda Hospitals, told HealthandMe.
Dr Krunal Tamakuwala, cardiologist at KD Hospital, Ahmedabad, pointed out that the real danger is not that these heart attacks are completely "symptomless," but that their symptoms are so common that they are easily ignored.
By the time a person finally sees a doctor, their heart may already be seriously damaged.
“Sometimes, it arrives silently, hidden behind complaints we consider minor. That is why doctors urge patients not to ignore symptoms that linger or feel unusual, even if they seem harmless at first,” Dr Tamakuwala told HealthandMe.
The experts shared that to boost heart health, the key is to
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