Most people are aware of type 1 and type 2 diabetes, but did you know there is a type 3 diabetes as well! It is a more obscure term. Although it is not an accepted medical diagnosis, type 3 diabetes has been discussed in the literature as a possible relationship between insulin resistance in the brain and Alzheimer's disease. This link has been described to help explain how metabolic disorders impact brain health, causing cognitive decline and dementia.

What is Type 3 Diabetes?

Type 3 diabetes is more of a misnomer because it should not be confused with type 3c diabetes, which relates to pancreatic dysfunction. The term "type 3 diabetes," on the other hand, has been loosely used by some scientists to analogously propose that Alzheimer's disease is strongly implicated with insulin resistance in the brain.

This concept was conceptualized by Dr. Suzanne de la Monte and Dr. Jack Wands of Brown University in the year 2008. This hypothesis postulated that Alzheimer's disease may be called type 3 diabetes for it bears many similarities with glucose metabolism disorder type 2 diabetes. Their concept arises from the basic principle that insulin is fundamental to blood sugar regulation, but it is also the case with the brain. When brain cells become insulin-resistant, they lose access to glucose, impairing their function.

Research published in the Journal of Diabetes Science and Technology supports this hypothesis by indicating that insulin resistance can be a significant contributor to the occurrence of dementia, also referred to as Alzheimer's. The symptoms of memory loss and diminished reasoning are associated with impaired glucose metabolism in the body, especially in the cerebral tissue.

Symptoms of Type 3 Diabetes

Although type 3 diabetes is not a "medical term," its symptoms correlate well with Alzheimer's diseases that are known to reduce the ability to think in an efficient manner and bring down brain health. These signs are:

- Loss of memory, especially short-term.

- Poor judgment and judgment ability

- Failure in recognizing people or places familiar once.

- Failure in the process of reading, writing or processing numbers

- Anxiety, agitation, or mood changes.

- Disorganized thoughts or confusion

- Lack of impulse control

As the disease advances, patients may be afflicted with severe complications including an inability to swallow or control their bodily functions. In the final stages, most patients die from fatal complications such as aspiration pneumonia.

Causes of Type 3 Diabetes

This may not be well understood with regards to type 3 diabetes, or the exact link between insulin resistance and Alzheimer's disease. Some identified contributing factors include the following:

1. Insulin Resistance

Insulin acts as an important regulatory mechanism of brain functions such as memory and cognition. The reduction in insulin signaling may impair metabolism of brain cells, thus bringing about neurodegeneration.

2. Type 2 Diabetes

These diseases show a strong relationship and those individuals diagnosed with type 2 diabetes have double chances of getting Alzheimer's. In the two, the main causes can be chronic inflammation, oxidative stress, and a defect in glucose metabolism.

3. Environmental and Lifestyle Factors

Insulin resistance associated with obesity, stress, and an unhealthy diet is considered a cause that may increase the chances of Alzheimer's disease.

Researches in Frontiers in Neuroscience and The Lancet Neurology have also highlighted that drugs used for antidiabetic medication may be crucial for the prevention or at least slowing down the course of Alzheimer's.

Treatments for Type 3 Diabetes

In 2022, in a study in Pharmaceuticals, researchers studied biomarker uptake in brain regions implicated in the faulty uptake and metabolism of blood sugar in Alzheimer’s patients.

Emerging Therapies

Research into such treatments as intranasal insulin has also been promising. Intranasal delivery of insulin directly to the brain has been reported to enhance glucose uptake by brain cells, improve memory, and boost cognitive performance. While such clinical trials have been shown to be successful, additional research is needed for safety and efficacy.

Medications

For patients being aggressive or agitated, antipsychotic drugs may be prescribed; however, therapies such as cognitive rehabilitation as well as cognitive stimulation therapy serve to preserve memory and executive function.

Lifestyle Interventions

Diet, exercise, and stress management are critical in preventing and managing insulin resistance. A review in the Journal of Alzheimer's Disease also highlighted the benefits of Kirtan Kriya meditation, which can regulate genes involved in insulin and glucose metabolism, improve sleep, and reduce inflammation.

Can Type 3 Diabetes Be Prevented?

Although type 3 diabetes is not officially recognized, its connection to Alzheimer’s disease underscores the importance of proactive measures for brain health. Some prevention strategies include:

1. Healthy Diet

Consuming a balanced diet rich in antioxidants, whole grains, and healthy fats may support brain health.

2. Regular Exercise

Physical activity improves insulin sensitivity, reduces inflammation, and enhances overall metabolic health.

3. Stress Reduction

Mindfulness practices, including meditation, have been shown to lower stress levels, which can reduce the risk of cognitive decline.

The term type 3 diabetes brings out the complex relationship between metabolic disorders and brain health. Even though it is not a recognized medical condition, the concept emphasizes the crucial role of insulin in brain function and its possible contribution to Alzheimer's disease. Continued research will hopefully provide hope for therapies such as intranasal insulin and lifestyle modifications.

When Robert F Kennedy Jr took charge of America's health as the Secretary of Health and Human Services in 2025, the promise was sweeping. It included: restoring trust, clean up the food supply, rethink vaccine, though he clearly did state during debates that he is not against it, and reshape a system he said had failed many families for decades.

On February 13, 2025, the day he was sworn in, the US President Trump said, "Our public health system has squandered the trust of our citizens. They don’t trust us. They don’t trust anybody, frankly. They’ve gone through hell.” Trump promised that Kennedy would "lead out campaign of historic reforms and restore faith in American health care". A year from now, Health and Me analyzes those MAHA (Make America Healthy Again) promises.

he Make America Healthy Again (MAHA) movement produced policy changes, lawsuits, agency upheavals and intense public debate, but also falling trust in public health agencies and uncertain long-term impact.

Read: I'm Not Afraid Of Germs, I Snorted Cocaine Off Toilet Seats, Says US Secretary of Health, RFK Jr

The Fight Against Ultra Processed Foods

Kennedy’s campaign had centered on a simple message: American children are sicker because their food is broken. As health secretary, he created a MAHA Commission to investigate children’s health.

Its first report blamed rising chronic illness partly on diet and raised alarms about herbicides like glyphosate and atrazine being found in children and pregnant women. Farmers and food companies revolted, lobbying lawmakers in agricultural states.

The backlash worked. By the commission’s follow-up report in September, pesticide references had vanished entirely, a clear sign of political limits.

Read: Under RFK Jr's MAHA, More Food Dyes Are Getting Banned In US

Still, Kennedy pushed nutrition policy aggressively. New dietary guidelines promoted whole milk, red meat and less ultraprocessed food. Supporters applauded a focus on real food, and food companies even pledged to remove artificial dyes by 2027.

But critics said the results were partial at best. Nutrition expert Dr. Marion Nestle told CNN that despite momentum, progress stalled: “One big disappointment is the lack of progress on removing industrial and agricultural chemicals from the food supply.”

An Anti-vaxxer's Vaccine Policy

No area defined Kennedy’s first year more than vaccines.

He fired members of a CDC advisory panel, replaced them, sometimes with skeptics, and cut the list of routinely recommended childhood vaccines from 17 to 11, aligning the U.S. closer to Denmark’s schedule. Several vaccines, including flu and hepatitis A, were removed from routine recommendations.

Supporters framed it as restoring parental choice. Critics called it dangerous.

Read: RFK Jr. Removes Entire CDC Vaccine Advisory Committee

Yale public health expert Dr. Jason Schwartz told CNN the consequences could be severe: “Today, the federal government’s public health agencies and leaders represent the greatest threat to efforts to prevent measles… a scenario that would have been inconceivable a few years ago.”

Outbreaks soon followed, measles deaths returned after a decade without them. And polling showed trust in the CDC falling from 59% to 47%.

Kennedy argued declining trust started before him and that transparency would fix it. But many scientists disagreed. Infectious disease expert Dr. Michael Osterholm told CNN the new approach replaced evidence with politics: “Decisions are being made based on ideology.”

Health Agencies Saw A Lot Of Hirings, Firings, And Restructuring

Within days of Kennedy’s swearing-in, thousands of employees across CDC, FDA and NIH were fired in a sweeping reorganization aimed at shrinking the department by about 20,000 workers.

Leadership churn followed. A CDC director was ousted, nominees withdrawn, senior officials resigned, and a major shooting at CDC headquarters, carried out by a man angry about vaccines, intensified tensions. Hundreds of staff later urged Kennedy to stop spreading misinformation.

Researchers warned expertise was disappearing. Johns Hopkins epidemiologist Dr. Caitlin Rivers told CNN local health departments depend on federal specialists: "A lot of those people aren’t there anymore.”

Read: How Susan Monarez's Appoint As CDC Director Can Change US Health Sector?

Meanwhile, Kennedy struggled with forces outside his control. According to Politico reporting, his attempts to regulate agricultural chemicals faltered because authority belonged to the Environmental Protection Agency and Republican lawmakers pushed back heavily.

At the Food and Drug Administration, Kennedy’s agenda pulled in two directions.

On one hand, the administration sought cheaper drugs and faster access. On the other, it raised evidence standards and blocked or slowed approvals, including scrutiny of a muscular dystrophy therapy after patient deaths.

Also Read: Top U.S. Medical Associations Ousted from CDC Vaccine Workgroups in Sudden Shake-Up

Even allies noticed contradictions. The agency alternated between right-to-try deregulation and skepticism toward pharmaceutical safety. The result: uncertainty for both industry and patients.

Restoring Faith In Public Health

Trump promised Kennedy would restore faith in public health. Instead, surveys show trust in both health agencies and Kennedy himself fell.

Read: What Is 'Make America Healthy Again' All About?

Nutrition reforms gained modest support. Drug price messaging resonated politically. But experts repeatedly emphasized the same conclusion: vaccine policy overshadowed everything else.

Nutrition policy expert Dr. Jerold Mande told CNN messaging that authorities had lied for decades may have backfired:

“Most people will take from that: we shouldn’t trust anybody."

The World Health Organization (WHO) is urging countries to accelerate efforts to provide proper eye care, as a new Lancet Global Health study shows that nearly half of all people across the world facing cataract‑related blindness still need access to surgery.

As of now, statistical models predict that the global coverage of cataract surgery is set to increase by about 8.4 percent this decade. However, progress needs to accelerate sharply to meet the World Health Assembly target of a 30 percent increase by 2030.

Devora Kestel, Director, WHO Department of Noncommunicable Diseases and Mental Health: "Cataract surgery is one of the most powerful tools we have to restore vision and transform lives. When people regain their sight, they regain independence, dignity, and opportunity."

The literature review, which analyzed reports from 68 country estimates for 2023 and 2024 shows that the African Region faces the greatest gap, with three in four people who need cataract surgery remaining untreated.

Additionally, women are disproportionately affected across all regions, consistently experiencing lower access to care than men.

Researchers noted that the gap in access to surgery was mostly due to long-standing structural barriers, including shortages and unequal distribution of trained eye-care professionals, high out-of-pocket costs, long waiting times and limited awareness or demand for surgery, even where services exist.

In addition, while age is the primary risk factor for cataract, other contributors such as prolonged UV-B exposure, tobacco use, corticosteroid use and diabetes can accelerate its development.

What Is A Cataract?

Most cataracts develop slowly and don't disturb eyesight early on. But with time, cataracts will eventually affect vision. Symptoms of cataracts include:

• Clouded, blurred or dim vision.
• Trouble seeing at night.
• Sensitivity to light and glare.
• Need for brighter light for reading and other activities.
• Seeing "halos" around lights.
• Frequent changes in eyeglass or contact lens prescription.
• Fading or yellowing of colors.
• Double vision in one eye.

At first, stronger lighting and eyeglasses can help deal with cataracts. But if impaired vision affects usual activities, cataract surgery might be needed. Surgery is generally a safe, effective procedure.

Can Rising Pollution Levels In India Worsen Eye Health?

The doctors confirmed that most cases now appear with patients who have allergies, dryness, burning sensations and excessive watering in the eyes. The pollution is not only affecting children, but adults are also equally impacted.

Dr Ikeda Lal, Senior Cornea, Cataract and Refractive Surgery Specialist at Delhi Eye Centre and Sir Ganga Ram Hospital told PTI: "Every year after Diwali, we brace for a rise in eye complaints. The number of patients complaining of itching, redness, and irritation has gone up by almost 50-60 per cent."

A study from 2022 published in the International Journal of Environmental Research and Public Health notes the adverse effects of air pollution on the eyes. Air pollution is a mix of complex gas-phase pollutants and particles that are disbursed into the atmosphere and are harmful.

It comprises:

• Sulfur dioxide
• Nitrogen dioxide
• Carbon dioxide
• Nitrogen monoxide
• Carbon monoxide
• Nitrogen oxides
• Particulate matter 2.5 or PM2.5
• Particulate matter 10 or PM10

Air pollution is known to cause cardiovascular disorders, respiratory tract problems, ocular disease, neurologic disease, cancer, and even death, notes the study.

In terms of its impact on the eyes, the pollutants usually work as irritants, which can cause inflammation and irritation in the eyes.

The cornea is the most sensitive structure in the human body due to its innervation in the ocular surface, which makes it extremely sensitive to environmental agents. The pollutants could thus cause conjunctivitis, which could become a frequent problem.

In addition to that, household pollution could also produce volatile organic compounds; for instance, formaldehyde could cause DNA damage in animal cells, and its carcinogenicity has been assessed by many studies too.

People around the world frequently worry about aging, worrying about physical decline, illness, and a loss of independence s they grow older.

However, researchers at the NYU School of Global Public Health have found that women who worry over their declining health may actually speed up the aging process due to the related-psychological stress.

Mariana Rodrigues, a PhD student at NYU School of Global Public Health and the first author of the study, said: "Our research suggests that subjective experiences may be driving objective measures of aging. Aging-related anxiety is not merely a psychological concern, but may leave a mark on the body with real health consequences."

"We know from previous research that anxiety, depression, and mental health in general are associated with a number of physical health outcomes, but until now researchers haven’t focused on whether there is a correlation between worrying about aging and the process of aging itself.

“Women in midlife may also be multiple in roles, including caring for their aging parents. As they see older family members grow older and become sick, they may worry about whether the same thing will happen to them".

After analyzing data from 726 women, the researchers while worrying about declining health, had the strongest associations with biological aging, anxiety about declining attractiveness and fertility were not significantly associated with it.

They theorized that this may be because research shows that health-related concerns are more common and persist over time, while worries about beauty and reproductive health may fade with age.

“Aging is a universal experience,” said Rodrigues. “We need to start a discourse about how we as a society—through our norms, structural factors, and interpersonal relationships—address the challenges of aging.”

Warning Signs You May Be Aging Faster

• Constant fatigue and loss of energy: Everyday tasks feel harder, and the body tires more quickly than before.
• Skin and hair changes: Reduced collagen and keratin production leads to sagging, wrinkles, and thinning or loss of hair.
• Cognitive decline: Memory lapses, difficulty in planning, and problems with calculations may point to aging-related changes in the brain as grey matter begins to shrink.
• Chronic conditions: Lifestyle diseases like diabetes and hypertension are often tied to aging, linked to reduced insulin production and thicker, slower blood flow.

Can Premature Aging Be Prevented?

Excessive exposure to the sun speeds up skin aging, a process known as photoaging. This alone causes about 90% of the visible changes we see in skin, such as wrinkles, age spots, and rough texture. UV rays also damage cells, which raises the risk of skin cancer.

Blue light and infrared light: The remaining 10% of skin damage comes from high-energy visible (blue) light and infrared light. Blue light comes from the sun and also from screens, while infrared is the heat we feel. These don’t raise cancer risk but they do weaken collagen and elasticity, making skin sag sooner.

Other lifestyle factors that speed up aging include:

• Smoking: Nicotine toxins break down collagen and elastin, causing sagging skin, wrinkles, and a hollow look.
• Poor diet: Diets high in sugar and refined carbs may speed up aging, while diets rich in fruits and vegetables help protect the skin.
• Alcohol: Heavy drinking dehydrates and damages skin over time.
• Lack of sleep: Poor or insufficient sleep has been linked to faster cellular aging.
• Chronic stress: High cortisol levels from stress reduce substances like collagen and hyaluronic acid that keep skin smooth and firm.