Most people are aware of type 1 and type 2 diabetes, but did you know there is a type 3 diabetes as well! It is a more obscure term. Although it is not an accepted medical diagnosis, type 3 diabetes has been discussed in the literature as a possible relationship between insulin resistance in the brain and Alzheimer's disease. This link has been described to help explain how metabolic disorders impact brain health, causing cognitive decline and dementia.

What is Type 3 Diabetes?

Type 3 diabetes is more of a misnomer because it should not be confused with type 3c diabetes, which relates to pancreatic dysfunction. The term "type 3 diabetes," on the other hand, has been loosely used by some scientists to analogously propose that Alzheimer's disease is strongly implicated with insulin resistance in the brain.

This concept was conceptualized by Dr. Suzanne de la Monte and Dr. Jack Wands of Brown University in the year 2008. This hypothesis postulated that Alzheimer's disease may be called type 3 diabetes for it bears many similarities with glucose metabolism disorder type 2 diabetes. Their concept arises from the basic principle that insulin is fundamental to blood sugar regulation, but it is also the case with the brain. When brain cells become insulin-resistant, they lose access to glucose, impairing their function.

Research published in the Journal of Diabetes Science and Technology supports this hypothesis by indicating that insulin resistance can be a significant contributor to the occurrence of dementia, also referred to as Alzheimer's. The symptoms of memory loss and diminished reasoning are associated with impaired glucose metabolism in the body, especially in the cerebral tissue.

Symptoms of Type 3 Diabetes

Although type 3 diabetes is not a "medical term," its symptoms correlate well with Alzheimer's diseases that are known to reduce the ability to think in an efficient manner and bring down brain health. These signs are:

- Loss of memory, especially short-term.

- Poor judgment and judgment ability

- Failure in recognizing people or places familiar once.

- Failure in the process of reading, writing or processing numbers

- Anxiety, agitation, or mood changes.

- Disorganized thoughts or confusion

- Lack of impulse control

As the disease advances, patients may be afflicted with severe complications including an inability to swallow or control their bodily functions. In the final stages, most patients die from fatal complications such as aspiration pneumonia.

Causes of Type 3 Diabetes

This may not be well understood with regards to type 3 diabetes, or the exact link between insulin resistance and Alzheimer's disease. Some identified contributing factors include the following:

1. Insulin Resistance

Insulin acts as an important regulatory mechanism of brain functions such as memory and cognition. The reduction in insulin signaling may impair metabolism of brain cells, thus bringing about neurodegeneration.

2. Type 2 Diabetes

These diseases show a strong relationship and those individuals diagnosed with type 2 diabetes have double chances of getting Alzheimer's. In the two, the main causes can be chronic inflammation, oxidative stress, and a defect in glucose metabolism.

3. Environmental and Lifestyle Factors

Insulin resistance associated with obesity, stress, and an unhealthy diet is considered a cause that may increase the chances of Alzheimer's disease.

Researches in Frontiers in Neuroscience and The Lancet Neurology have also highlighted that drugs used for antidiabetic medication may be crucial for the prevention or at least slowing down the course of Alzheimer's.

Treatments for Type 3 Diabetes

In 2022, in a study in Pharmaceuticals, researchers studied biomarker uptake in brain regions implicated in the faulty uptake and metabolism of blood sugar in Alzheimer’s patients.

Emerging Therapies

Research into such treatments as intranasal insulin has also been promising. Intranasal delivery of insulin directly to the brain has been reported to enhance glucose uptake by brain cells, improve memory, and boost cognitive performance. While such clinical trials have been shown to be successful, additional research is needed for safety and efficacy.

Medications

For patients being aggressive or agitated, antipsychotic drugs may be prescribed; however, therapies such as cognitive rehabilitation as well as cognitive stimulation therapy serve to preserve memory and executive function.

Lifestyle Interventions

Diet, exercise, and stress management are critical in preventing and managing insulin resistance. A review in the Journal of Alzheimer's Disease also highlighted the benefits of Kirtan Kriya meditation, which can regulate genes involved in insulin and glucose metabolism, improve sleep, and reduce inflammation.

Can Type 3 Diabetes Be Prevented?

Although type 3 diabetes is not officially recognized, its connection to Alzheimer’s disease underscores the importance of proactive measures for brain health. Some prevention strategies include:

1. Healthy Diet

Consuming a balanced diet rich in antioxidants, whole grains, and healthy fats may support brain health.

2. Regular Exercise

Physical activity improves insulin sensitivity, reduces inflammation, and enhances overall metabolic health.

3. Stress Reduction

Mindfulness practices, including meditation, have been shown to lower stress levels, which can reduce the risk of cognitive decline.

The term type 3 diabetes brings out the complex relationship between metabolic disorders and brain health. Even though it is not a recognized medical condition, the concept emphasizes the crucial role of insulin in brain function and its possible contribution to Alzheimer's disease. Continued research will hopefully provide hope for therapies such as intranasal insulin and lifestyle modifications.

People troubled by increasing forgetfulness are being advised to have their vitamin levels checked, as a shortage of one essential nutrient can cause symptoms that closely resemble dementia. According to the NHS, a deficiency in a key vitamin may lead to neurological issues that affect the nervous system, including problems with memory.

As per Mirror, Dr Eric Berg, DC, has also drawn attention to what he calls the “leading vitamin deficiency that mimics dementia,” identifying vitamin B12 as a major concern. Adequate levels of this nutrient are vital because it helps form red blood cells that carry oxygen through the body, supports DNA production and regulation, and converts food into usable energy.

Dr Berg, well known for promoting healthy ketosis and intermittent fasting, is the author of the bestselling book The Healthy Keto Plan and runs Dr Berg Nutritionals. He has since moved away from clinical practice to focus on sharing health information through online platforms.

Why Is Vitamin B12 Important?

Vitamin B12 is essential for the healthy functioning of the central nervous system and plays a key role in maintaining clear thinking and memory. When levels drop, people may experience weakness, numbness, difficulty walking, nausea, unintended weight loss, irritability, extreme tiredness, and a fast or irregular heartbeat.

Bones, hair, skin, and nails may also suffer. Dr Berg explains: “Vitamin B12 is essential for normal brain function. Without it, symptoms similar to dementia can develop. This vitamin is mainly found in animal-based foods, although some microbes can produce it. Low intake of animal products is the most common reason for vitamin B12 deficiency.”

Research suggests that low B12 levels can impair nerve function and may contribute to conditions such as dementia, peripheral neuropathy, or subacute combined degeneration. A deficiency can also interfere with DNA synthesis and cause homocysteine levels to rise.

What Does The NHS Say?

On its official website, the NHS states: “Most cases of vitamin B12 or folate deficiency can be treated easily and effectively, so complications are uncommon. However, complications may sometimes occur, particularly if the deficiency has been present for a long time. If neurological problems develop, they can occasionally be permanent.”

The NHS explains that a lack of vitamin B12 may lead to neurological symptoms such as:

• vision problems
• memory loss
• pins and needles
• loss of physical coordination (ataxia), which can affect speech or walking
• damage to parts of the nervous system (peripheral neuropathy), especially in the legs

A study published in 2020 found a “clear association between low vitamin B12 levels and progressive cognitive impairment.” Researchers added that more large-scale studies are needed to confirm these findings and to see whether correcting the deficiency can slow cognitive decline.

More than one in ten older adults are estimated to have low vitamin B12 levels. In addition to memory problems, a deficiency may cause other neurological and psychological symptoms, including:

• confusion
• difficulty with thinking and reasoning
• tingling or numbness in the hands and feet
• poor balance and coordination
• fatigue
• weakness
• vision disturbances
• peripheral neuropathy affecting the nervous system
• depression, anxiety, paranoia, and delusions
• incontinence
• loss of taste and smell

Can A Vitamin B12 Deficiency Be Treated?

If a vitamin B12 deficiency is diagnosed, treatment usually involves high-dose supplementation, either through injections or oral supplements. GPs may arrange regular blood tests to monitor B12 levels over time.

As per The Mirror, the longer the deficiency goes untreated, the higher the risk of permanent damage. That said, it is often reversible, with many people noticing marked improvement within three to six months. Other signs of vitamin B12 deficiency may include:

• numbness, tingling, and pins and needles in the arms and legs
• pale skin
• unsteady walking or balance problems
• a rapid heartbeat
• shortness of breath
• a swollen tongue

“As we get older, HCL levels naturally decline. They can also drop if you take antacids or medications like Metformin. Interestingly, acid reflux can actually be a sign of low HCL, and antacids may worsen the problem. Betaine hydrochloride is one way to support normal stomach acidity.”

What Else Is Worth Being Aware Of?

Deficiencies in other nutrients may also cause symptoms that resemble dementia. Dr Berg highlights vitamin B1, which is often linked to high sugar and carbohydrate intake. Zinc deficiency, sometimes related to phytic acid found in grains, and low vitamin D levels due to limited sun exposure, may also play a role. “Nutrient deficiencies can shrink the hippocampus, which is linked to Alzheimer’s disease,” Dr Berg said.

The NHS has released fresh guidance on how to manage flu symptoms, setting out four simple steps that could help people recover faster. Influenza, commonly known as flu, is a highly contagious viral illness that affects the respiratory system, including the nose, throat, and lungs. It is marked by a sudden onset of fever, muscle aches, headaches, a persistent dry cough, and extreme tiredness, making it far more serious than the common cold.

Recent data from NHS England shows that in the first week of January, an average of 2,924 hospital beds across England were taken up by patients with flu. This figure reflects a nine per cent increase compared with the previous week.

With flu cases continuing to climb, the NHS has shared several important steps that people can follow to help support a quicker recovery.

NHS Shares Four Steps To Tackle Flu Symptoms 2026

In a recent update, NHS England warned that social gatherings during Christmas and New Year may have led to a resurgence of winter illnesses. NHS national medical director Professor Meghana Pandit said: “It is clear that the pressure on the NHS this winter is far from easing, with hospitals once again seeing a rise in patients admitted with flu and other respiratory viruses last week.

“The colder weather is also bringing more vulnerable patients to A&E with breathing difficulties, along with an increase in injuries caused by slips and falls in icy conditions, making this an exceptionally demanding period.”

According to the Mirror, she added: “Staff continue to work extremely hard, with teams across the country doing everything possible to ensure patients receive the care they need. It remains important for people to seek care as usual, and there are still many opportunities to get vaccinated and protect yourself against flu.”

Flu Symptoms 2026

The NHS says flu symptoms tend to appear suddenly and may include:

• A high temperature that comes on quickly
• Aches and pains throughout the body
• Feeling very tired or exhausted
• A dry, persistent cough
• A sore throat
• Headaches
• Trouble sleeping
• Loss of appetite
• Diarrhoea or stomach pain
• Feeling sick or being sick

Children may experience similar symptoms, but they can also have earaches and may appear more tired or less active than usual.

Flu Symptoms 2026: NHS Advice

The NHS states: “If you have flu, there are steps you can take to help yourself recover more quickly.”

• Rest and get plenty of sleep
• Keep yourself warm
• Use paracetamol or ibuprofen to reduce fever and ease aches and pains
• Drink plenty of fluids to prevent dehydration, aiming for urine that is pale yellow or clear

Flu Symptoms 2026: When To Seek Help?

You should contact NHS 111 or arrange an urgent GP appointment if you or your child have flu symptoms and:

• You are concerned about your baby’s or child’s condition
• You are aged 65 or over
• You are pregnant
• You have a long-term health condition, such as diabetes or a problem affecting the heart, lungs, kidneys, brain, or nerves
• You have a weakened immune system, for example due to chemotherapy or HIV
• Your symptoms have not improved after seven days
• You develop sudden chest pain
• You have trouble breathing
• You begin coughing up large amounts of blood

Cipla, a global name in inhalation therapies, has announced the launch of Afrezza, the world’s only rapid-acting inhaled insulin, in India. The drug is approved for adults with type 1 and type 2 diabetes to help manage high blood sugar levels and represents a notable change in how insulin can be delivered in a country facing a growing diabetes crisis.

For many patients, injecting insulin during long workdays or in public spaces can be uncomfortable or inconvenient. While insulin injections are widely used, awareness around inhaled insulin remains limited. Below, we explain how inhaled insulin works and what it means for people living with diabetes.

What Is Inhaled Insulin?

Inhaled insulin is a fast-acting form of insulin that is taken as a fine powder through an inhaler. Instead of being injected, it is breathed into the lungs, where it is quickly absorbed into the bloodstream to manage blood sugar spikes that occur after meals. This makes it a needle-free option for adults with type 1 or type 2 diabetes.

It begins working very rapidly, often just before or at the start of a meal, and exits the body sooner than injectable insulin. Because of this, it may lower the risk of insulin stacking and offers greater flexibility around mealtimes. Afrezza is currently the main FDA-approved inhaled insulin available.

How To Use Inhaled Insulin?

The insulin comes as a dry powder and is taken using a small, discreet inhaler with single-use cartridges available in 4, 8, and 12-unit doses. It has been approved by the FDA for adults with type 1 and type 2 diabetes to help control blood sugar rises after meals. “Its absorption into the bloodstream is faster than injectable rapid-acting insulins such as lispro or aspart,” said Dr Hetashvi Gondaliya, as reported by The Indian Express.

How Does Inhaled Insulin Work For Diabetic People?

Before starting inhaled insulin, patients are required to undergo lung function tests. The insulin itself is identical to the insulin used in injections. What differs is the way it enters the body.

In simple terms, the insulin is not new, only the method of delivery is. Once inhaled, it is absorbed through the lungs, passes into the bloodstream, and helps control the rise in blood sugar levels that happens after eating.

Is Inhaled Insulin Better Than Injectable Insulin?

Inhaled insulin is not necessarily better for everyone, but it offers an alternative to injections. It works faster to control post-meal blood sugar levels and may appeal to people who dislike needles. However, it is less efficient than injected insulin, requires a specific inhaler, and is not suitable for all patients.

Studies show that blood sugar control is similar to injectable insulin, but inhaled insulin must still be used along with long-acting basal insulin. It is best viewed as an option rather than a replacement.

Is Inhaled Insulin Suitable For All Diabetic Patients?

According to the National Institutes of Health, inhaled insulin is not appropriate for everyone. It may be considered for adults with type 1 or type 2 diabetes who want a needle-free option or need rapid control of blood sugar after meals.

However, it is not recommended for people who smoke or have smoked in the past six months, or for those with lung conditions such as asthma, COPD, or bronchitis. It is also not approved for children or pregnant women. Lung health and ongoing insulin needs must be carefully evaluated before starting this treatment.

Always consult your doctor before switching to or starting inhaled insulin. Your healthcare provider can help determine whether it is safe and suitable for you based on your medical history and lung health.