Most people are aware of type 1 and type 2 diabetes, but did you know there is a type 3 diabetes as well! It is a more obscure term. Although it is not an accepted medical diagnosis, type 3 diabetes has been discussed in the literature as a possible relationship between insulin resistance in the brain and Alzheimer's disease. This link has been described to help explain how metabolic disorders impact brain health, causing cognitive decline and dementia.

What is Type 3 Diabetes?

Type 3 diabetes is more of a misnomer because it should not be confused with type 3c diabetes, which relates to pancreatic dysfunction. The term "type 3 diabetes," on the other hand, has been loosely used by some scientists to analogously propose that Alzheimer's disease is strongly implicated with insulin resistance in the brain.

This concept was conceptualized by Dr. Suzanne de la Monte and Dr. Jack Wands of Brown University in the year 2008. This hypothesis postulated that Alzheimer's disease may be called type 3 diabetes for it bears many similarities with glucose metabolism disorder type 2 diabetes. Their concept arises from the basic principle that insulin is fundamental to blood sugar regulation, but it is also the case with the brain. When brain cells become insulin-resistant, they lose access to glucose, impairing their function.

Research published in the Journal of Diabetes Science and Technology supports this hypothesis by indicating that insulin resistance can be a significant contributor to the occurrence of dementia, also referred to as Alzheimer's. The symptoms of memory loss and diminished reasoning are associated with impaired glucose metabolism in the body, especially in the cerebral tissue.

Symptoms of Type 3 Diabetes

Although type 3 diabetes is not a "medical term," its symptoms correlate well with Alzheimer's diseases that are known to reduce the ability to think in an efficient manner and bring down brain health. These signs are:

- Loss of memory, especially short-term.

- Poor judgment and judgment ability

- Failure in recognizing people or places familiar once.

- Failure in the process of reading, writing or processing numbers

- Anxiety, agitation, or mood changes.

- Disorganized thoughts or confusion

- Lack of impulse control

As the disease advances, patients may be afflicted with severe complications including an inability to swallow or control their bodily functions. In the final stages, most patients die from fatal complications such as aspiration pneumonia.

Causes of Type 3 Diabetes

This may not be well understood with regards to type 3 diabetes, or the exact link between insulin resistance and Alzheimer's disease. Some identified contributing factors include the following:

1. Insulin Resistance

Insulin acts as an important regulatory mechanism of brain functions such as memory and cognition. The reduction in insulin signaling may impair metabolism of brain cells, thus bringing about neurodegeneration.

2. Type 2 Diabetes

These diseases show a strong relationship and those individuals diagnosed with type 2 diabetes have double chances of getting Alzheimer's. In the two, the main causes can be chronic inflammation, oxidative stress, and a defect in glucose metabolism.

3. Environmental and Lifestyle Factors

Insulin resistance associated with obesity, stress, and an unhealthy diet is considered a cause that may increase the chances of Alzheimer's disease.

Researches in Frontiers in Neuroscience and The Lancet Neurology have also highlighted that drugs used for antidiabetic medication may be crucial for the prevention or at least slowing down the course of Alzheimer's.

Treatments for Type 3 Diabetes

In 2022, in a study in Pharmaceuticals, researchers studied biomarker uptake in brain regions implicated in the faulty uptake and metabolism of blood sugar in Alzheimer’s patients.

Emerging Therapies

Research into such treatments as intranasal insulin has also been promising. Intranasal delivery of insulin directly to the brain has been reported to enhance glucose uptake by brain cells, improve memory, and boost cognitive performance. While such clinical trials have been shown to be successful, additional research is needed for safety and efficacy.

Medications

For patients being aggressive or agitated, antipsychotic drugs may be prescribed; however, therapies such as cognitive rehabilitation as well as cognitive stimulation therapy serve to preserve memory and executive function.

Lifestyle Interventions

Diet, exercise, and stress management are critical in preventing and managing insulin resistance. A review in the Journal of Alzheimer's Disease also highlighted the benefits of Kirtan Kriya meditation, which can regulate genes involved in insulin and glucose metabolism, improve sleep, and reduce inflammation.

Can Type 3 Diabetes Be Prevented?

Although type 3 diabetes is not officially recognized, its connection to Alzheimer’s disease underscores the importance of proactive measures for brain health. Some prevention strategies include:

1. Healthy Diet

Consuming a balanced diet rich in antioxidants, whole grains, and healthy fats may support brain health.

2. Regular Exercise

Physical activity improves insulin sensitivity, reduces inflammation, and enhances overall metabolic health.

3. Stress Reduction

Mindfulness practices, including meditation, have been shown to lower stress levels, which can reduce the risk of cognitive decline.

The term type 3 diabetes brings out the complex relationship between metabolic disorders and brain health. Even though it is not a recognized medical condition, the concept emphasizes the crucial role of insulin in brain function and its possible contribution to Alzheimer's disease. Continued research will hopefully provide hope for therapies such as intranasal insulin and lifestyle modifications.

As the 2026-27 flu season begins in the US, doctors are reminding people that influenza can cause more than just cough, fever and a runny nose. Symptoms can come on suddenly and affect the entire body, with some patients also developing gastrointestinal symptoms.

During the 2025-2026 flu season, influenza caused at least 32 million illnesses, 390,000 hospitalizations and 24,000 deaths in the US, according to preliminary data from the Centers for Disease Control and Prevention (CDC).

According to the World Health Organization, from February through August 2026, influenza A(H1N1)pdm09, A(H3N2) and influenza B viruses circulated across regions. Influenza A viruses predominated in most regions, while influenza B dominated in Northern and Western Africa, North America and Eastern Asia.

While it is too early to know what the season ahead will look like, knowing the range of flu symptoms can help people recognize the infection. These include the classic symptoms of sudden fever, chills, body aches and extreme fatigue, as well as vomiting and diarrhea in some children.

Flu Symptoms Can Come On Suddenly

Also read: WHO Sets 2027 Flu Vaccine Strains; US States Can Now Order Free COVID Shots For Kids

Influenza commonly affects the nose, throat and lungs, but its symptoms can be widespread.

The most common symptoms include:

• Fever

• Chills

• Body aches

• Extreme fatigue

• Headache

• Sore throat

• Runny or stuffy nose

• Cough

Family physician Carlos Galindo at Texas Health Family Care said fever, chills and body aches are the classic flu combination. People may also develop a sore throat, runny nose and headache, according to the American Medical Association.

Unlike the gradual tiredness that can accompany a cold, flu-related fatigue can be intense.

Galindo described it as significant lethargy and malaise, with some patients feeling completely drained.

Watch For Severe Body Aches And Fatigue

One of the key features doctors want people to recognize is how quickly influenza can make someone feel unwell.

Family physician Christopher Zipp of Atlantic Health in Morristown, New Jersey, said flu symptoms can develop over just a few hours, with fever, chills and body aches appearing suddenly.

However, flu symptoms can overlap with those of other respiratory infections, so symptoms alone cannot always confirm that someone has influenza.

Read More: Fall Vaccines 2026: US Doctors Issue COVID, Flu And RSV Jab Guidance

Children Can Have Vomiting And Diarrhea

Flu symptoms can also differ between children and adults. While fever, chills, body aches and respiratory symptoms are common, children may also develop gastrointestinal symptoms such as vomiting and diarrhea.

These symptoms can occur alongside cough, sore throat or other signs of respiratory infection.

When Can Flu Become Serious?

For most people, influenza is an unpleasant but temporary illness. However, it can sometimes lead to complications such as pneumonia and hospitalization, particularly in people with underlying health conditions.

Symptoms that become severe or worsen rather than improve warrant medical attention, especially among people at higher risk of complications.

In the US, many flu cases are seen between January and March, although influenza can circulate outside the peak season as well.

Doctors generally recommend flu vaccination around September or October to build protection before activity increases. It takes about two weeks for the body to develop protection after vaccination. Flu vaccination has been shown to reduce flu-related doctor visits by about 40% to 60%.

A mammogram is routinely used to detect early signs of breast cancer, but the imaging test may also provide clues about a woman’s cardiovascular health.

Cardiovascular disease is a major cause of death among women. Yet, experts say heart disease in women can be overlooked because symptoms and risk factors may differ from the patterns traditionally associated with men.

Why Heart Disease Can Be Missed In Women

Prof Rob Galloway of University Hospitals Sussex NHS Foundation Trust, writing in the Daily Mail, highlighted the need to identify cardiovascular disease in women earlier.

Citing a 2021 The Lancet study, he noted that women with cardiovascular disease remain “understudied, under-recognized, underdiagnosed, and undertreated.”

Galloway said he regularly sees women, particularly those in their 60s, arriving in emergency care with heart attacks after earlier symptoms were attributed to less serious causes.

“If that had been recognized, she could have been admitted, and if needed, had a stent (a mesh tube) inserted to open the artery before it was blocked,” he wrote.

“The truth is doctors are not as good as we should be at recognizing heart disease in women, or understanding their risk,” he added.

Also read: New Breast Cancer Guidelines Recommend Mammograms Every Two Years for Women

Heart Attack Symptoms May Look Different In Women

Women may experience heart attacks differently, with symptoms such as breathlessness, nausea, fatigue, or back, neck and jaw pain. Galloway also highlighted female-specific risk factors, which include:

• Preeclampsia or high blood pressure during pregnancy
• Gestational diabetes
• Premature menopause
• Polycystic ovary syndrome (PCOS)

He said these factors are not always routinely included when assessing a woman’s long-term cardiovascular risk.

What Can A Mammogram Reveal About Heart Risk?

Read More: World Heart Day: You Feel Healthy. But Plaque May Already Be Building In Your Arteries In Your 20s

Prof Galloway suggested that routine breast screening could potentially offer another opportunity to identify cardiovascular risk.

When blood vessels are damaged, calcium can accumulate in their walls. Mammograms can sometimes detect calcium deposits in the arteries of the breast, known as breast arterial calcification (BAC).

BAC is different from calcium buildup in the coronary arteries, but its presence has been associated with a higher risk of cardiovascular events such as heart attack and stroke. Some radiologists may therefore flag the finding to the treating doctor.

Could AI Detect Heart Risk From Mammograms?

Prof Galloway also discussed the potential role of artificial intelligence in identifying and measuring breast arterial calcification.

A European Heart Journal study used AI to assess mammograms from over 123,500 US women. Compared with no calcification, mild breast arterial calcification was linked to a 30% higher cardiovascular event risk, moderate to 75–80% higher risk, and severe to roughly three times higher risk.

The association persisted even after researchers accounted for established cardiovascular risk factors such as obesity and smoking.

Could Mammograms Become A Cardiovascular Screening Tool?

Prof Galloway said that the potential advantage is that the mammogram has already been performed for breast screening. If arterial calcification is identified, that information could potentially be included with the screening result and prompt a broader cardiovascular risk assessment.

Depending on the woman's overall risk, doctors could then consider measures such as more intensive management of blood pressure or cholesterol.

A coronary artery calcium scan is another way to assess calcium buildup in the arteries supplying the heart. It uses a CT scan to detect and measure coronary artery calcium and can help inform cardiovascular risk assessment in appropriate patients.

One may dismiss a recurring ache in the calf or thigh while walking may as a muscle problem, especially if it settles after sitting or resting. But leg pain that repeatedly appears while walking and eases after resting can sometimes be due to a circulation problem called peripheral artery disease (PAD).

The condition occurs when arteries that carry blood to the legs become narrow, usually because of atherosclerosis, which is the buildup of fatty deposits inside blood vessels. PAD can be a major sign that the same process is also affecting arteries in the heart and brain, signalling a major cardiovascular risk.

Women May Overlook The Symptoms

PAD can be difficult to identify as it comes with ordinary symptoms that could be tied to ageing or injury.

Women may neglect it as they may experience less obvious symptoms, including leg fatigue or weakness rather than cramping. This is because the condition is affected by ageing, fitness, or a musculoskeletal issue.

Apart from pain during walking, possible symptoms include:

• Coldness in one foot or leg
• Numbness or weakness
• Changes in the colour of the skin
• Shiny skin or loss of hair on the legs
• Slow-growing toenails
• Sores on the feet or legs that heal slowly
• Pain in the feet or toes, particularly at rest in more advanced disease

Some people may have no noticeable symptoms, which can allow PAD to progress without being recognised, leading to serious complications.

Also read: Pomegranate Compound Improves Heart Function By Up To 80% In Early Heart Failure Study

Canada Is Focusing On PAD

The disease has prompted a new Canadian National Action Plan for Peripheral Artery Disease, developed by vascular medicine experts with the Canadian Society of Vascular Medicine and Prevention.

The plan calls for greater public awareness, early diagnosis, better access to ankle-pressure testing, supervised exercise programmes and specialised care for people with PAD.

The Canadian authors also said that PAD can be difficult to diagnose in rural and remote communities and among Indigenous Peoples and other underprivileged populations, where access to preventive care and vascular specialists may be limited.

Delayed diagnosis can mean that people are only identified after complications like non-healing wounds or in severe cases, amputation.

Also read: 100% Blockage At 18, 25% Patients Under 40: On World Heart Day, Cardiologists Reveal An Alarming Heart Attack Pattern

PAD Is Linked To Heart Attack And Stroke

PAD happens when narrow and blocked arteries reduce the blood flow to the legs. When the muscles need more oxygen during walking or exercise, the reduced circulation can lead to uncomfortable pain.

This symptom is called intermittent claudication. The pain usually develops in the calf, thigh or buttocks while walking. It subsides or improves after sitting down or resting the legs.

But not everyone experiences this symptom. Some may instead face tiredness in the legs, weakness, numbness or just discomfort, making it easier to dismiss the symptom.

The arteries in the legs are not isolated from the rest of the circulatory system. PAD is usually caused due to atherosclerosis, the same underlying process that could lead to thinner arteries supplying blood to the heart and brain.

As a result, having PAD can indicate a higher risk of heart attack, stroke and other cardiovascular complications. PAD risk increases with age, but several other lifestyle factors can contribute. These include:

• Smoking
• Diabetes
• High blood pressure
• High cholesterol
• Family history of vascular disease

Diabetes is most likely to contribute to PAD because persistently high blood sugar can damage blood vessels and increase the risk of atherosclerosis.

When To Seek Medical Intervention?

If leg pain or unusual tiredness keeps interrupting your life, it is worth getting evaluated, particularly if you have diabetes, smoke or have high blood pressure or cholesterol.

Doctors may assess circulation using an ankle-brachial index (ABI), which compares blood pressure in the ankle with blood pressure in the arm.

Treatment may include lifestyle changes like increasing physical activity, quitting smoking and medicines to manage cholesterol, blood pressure, and blood clotting risk. Severe blockages may also require medical procedures.