Most people are aware of type 1 and type 2 diabetes, but did you know there is a type 3 diabetes as well! It is a more obscure term. Although it is not an accepted medical diagnosis, type 3 diabetes has been discussed in the literature as a possible relationship between insulin resistance in the brain and Alzheimer's disease. This link has been described to help explain how metabolic disorders impact brain health, causing cognitive decline and dementia.

What is Type 3 Diabetes?

Type 3 diabetes is more of a misnomer because it should not be confused with type 3c diabetes, which relates to pancreatic dysfunction. The term "type 3 diabetes," on the other hand, has been loosely used by some scientists to analogously propose that Alzheimer's disease is strongly implicated with insulin resistance in the brain.

This concept was conceptualized by Dr. Suzanne de la Monte and Dr. Jack Wands of Brown University in the year 2008. This hypothesis postulated that Alzheimer's disease may be called type 3 diabetes for it bears many similarities with glucose metabolism disorder type 2 diabetes. Their concept arises from the basic principle that insulin is fundamental to blood sugar regulation, but it is also the case with the brain. When brain cells become insulin-resistant, they lose access to glucose, impairing their function.

Research published in the Journal of Diabetes Science and Technology supports this hypothesis by indicating that insulin resistance can be a significant contributor to the occurrence of dementia, also referred to as Alzheimer's. The symptoms of memory loss and diminished reasoning are associated with impaired glucose metabolism in the body, especially in the cerebral tissue.

Symptoms of Type 3 Diabetes

Although type 3 diabetes is not a "medical term," its symptoms correlate well with Alzheimer's diseases that are known to reduce the ability to think in an efficient manner and bring down brain health. These signs are:

- Loss of memory, especially short-term.

- Poor judgment and judgment ability

- Failure in recognizing people or places familiar once.

- Failure in the process of reading, writing or processing numbers

- Anxiety, agitation, or mood changes.

- Disorganized thoughts or confusion

- Lack of impulse control

As the disease advances, patients may be afflicted with severe complications including an inability to swallow or control their bodily functions. In the final stages, most patients die from fatal complications such as aspiration pneumonia.

Causes of Type 3 Diabetes

This may not be well understood with regards to type 3 diabetes, or the exact link between insulin resistance and Alzheimer's disease. Some identified contributing factors include the following:

1. Insulin Resistance

Insulin acts as an important regulatory mechanism of brain functions such as memory and cognition. The reduction in insulin signaling may impair metabolism of brain cells, thus bringing about neurodegeneration.

2. Type 2 Diabetes

These diseases show a strong relationship and those individuals diagnosed with type 2 diabetes have double chances of getting Alzheimer's. In the two, the main causes can be chronic inflammation, oxidative stress, and a defect in glucose metabolism.

3. Environmental and Lifestyle Factors

Insulin resistance associated with obesity, stress, and an unhealthy diet is considered a cause that may increase the chances of Alzheimer's disease.

Researches in Frontiers in Neuroscience and The Lancet Neurology have also highlighted that drugs used for antidiabetic medication may be crucial for the prevention or at least slowing down the course of Alzheimer's.

Treatments for Type 3 Diabetes

In 2022, in a study in Pharmaceuticals, researchers studied biomarker uptake in brain regions implicated in the faulty uptake and metabolism of blood sugar in Alzheimer’s patients.

Emerging Therapies

Research into such treatments as intranasal insulin has also been promising. Intranasal delivery of insulin directly to the brain has been reported to enhance glucose uptake by brain cells, improve memory, and boost cognitive performance. While such clinical trials have been shown to be successful, additional research is needed for safety and efficacy.

Medications

For patients being aggressive or agitated, antipsychotic drugs may be prescribed; however, therapies such as cognitive rehabilitation as well as cognitive stimulation therapy serve to preserve memory and executive function.

Lifestyle Interventions

Diet, exercise, and stress management are critical in preventing and managing insulin resistance. A review in the Journal of Alzheimer's Disease also highlighted the benefits of Kirtan Kriya meditation, which can regulate genes involved in insulin and glucose metabolism, improve sleep, and reduce inflammation.

Can Type 3 Diabetes Be Prevented?

Although type 3 diabetes is not officially recognized, its connection to Alzheimer’s disease underscores the importance of proactive measures for brain health. Some prevention strategies include:

1. Healthy Diet

Consuming a balanced diet rich in antioxidants, whole grains, and healthy fats may support brain health.

2. Regular Exercise

Physical activity improves insulin sensitivity, reduces inflammation, and enhances overall metabolic health.

3. Stress Reduction

Mindfulness practices, including meditation, have been shown to lower stress levels, which can reduce the risk of cognitive decline.

The term type 3 diabetes brings out the complex relationship between metabolic disorders and brain health. Even though it is not a recognized medical condition, the concept emphasizes the crucial role of insulin in brain function and its possible contribution to Alzheimer's disease. Continued research will hopefully provide hope for therapies such as intranasal insulin and lifestyle modifications.

Doctors are reporting a change in the way the flu is presenting as a new strain spreads across the UK. Hospital admissions linked to the flu rose sharply at the beginning of the year, with an average of 2,924 people a day admitted by January 4. Four hospital trusts have declared critical incidents, citing ongoing and intense pressure on services. These include three trusts in Surrey and one in Kent.

Surrey Heartlands Trust said winter pressures had been made worse by a rise in flu and norovirus cases. NHS national medical director Professor Meghana Pandit said the situation remains difficult, with hospitals seeing another increase in patients admitted with flu and other respiratory infections last week.

She said it is still vital for people to seek medical help when needed and reminded the public that there are many chances to get vaccinated against flu. Health Secretary Wes Streeting also stressed that flu can be dangerous, especially for older adults, young children, and those with existing health problems. He urged everyone who qualifies to get their flu vaccine as soon as possible, calling it the best form of protection.

Doctors Report Unusual Symptoms As New Flu Strain Spreads Across The UK

Doctors say this latest flu strain appears to be causing different symptoms. The virus, known as subclade K, is a variant of the A H3N2 type of influenza.

Dr Mark Loafman told NBC Chicago that many patients are experiencing much higher fevers than usual. He said the fever can last five to seven days, which is longer than people typically expect and is a cause for concern.

In some cases, doctors say the fever does not respond well to common medicines such as paracetamol or ibuprofen. Lung specialist Dr Juanita Mora said this strain is linked to very high temperatures, a severe and persistent cough with heavy phlegm, vomiting, diarrhoea, and widespread joint and muscle pain.

Doctors have also noticed a rise in stomach-related symptoms, including nausea and vomiting, often referred to as gastrointestinal or GI issues. Dr Loafman said that, based on what doctors are seeing, adults infected with the subclade K strain seem to be showing more signs of GI illness than usual.

According to the NHS, flu symptoms usually appear suddenly and tend to be much more severe than those of a common cold. While most people start to recover within about a week, the illness can feel particularly harsh while it lasts.

Key Symptoms of Flu

The main symptoms usually begin abruptly and include:

• A sudden high temperature of 38C or higher
• Body aches affecting muscles and joints
• Extreme tiredness or exhaustion
• A dry cough
• A sore throat
• Headaches
• Problems sleeping
• Reduced appetite
• Nausea, vomiting, or diarrhoea, which are more common in children

How To Treat Flu at Home

Most people can deal with flu symptoms at home without needing to see a doctor. The NHS advises the following self-care measures:

• Rest and Sleep: Allow your body time and energy to fight off the infection.
• Stay Warm: Use extra layers or blankets to maintain body warmth.
• Hydration: Drink plenty of fluids to prevent dehydration. Your urine should be pale yellow or clear.
• Pain Relief: Paracetamol or ibuprofen can help reduce fever and ease aches. Avoid taking combination flu medicines alongside paracetamol tablets, as this can lead to taking too much.
• Sore Throat Relief: Gargle with salt water if you are an adult, or have hot drinks such as lemon and honey to ease discomfort.

People across the UK are being urged to follow basic safety steps as concerns grow over so-called “evolving” bacteria. A few decades ago, antibiotics were routinely prescribed for a wide range of illnesses and minor infections.

Today, many GPs are far more cautious about giving them out, largely because of the steady rise in bacteria that no longer respond to treatment. Figures from the UK Health Security Agency show that close to 400 antibiotic-resistant infections are being recorded every week in England.

What Are Antibiotic-Resistant Infections?

According to the World Health Organisation (WHO), antibiotic-resistant infections develop when bacteria change over time and stop responding to the medicines meant to kill them. As a result, infections that were once easy to treat become much harder, and in some cases impossible, to cure. This can lead to serious illness, longer hospital stays, and a higher risk of death.

While antibiotic resistance can occur naturally, the WHO warns that misuse and overuse of antibiotics in both humans and animals greatly speeds up the process. This allows resistant bacteria, often referred to as “superbugs,” to survive, multiply, and spread more easily.

Why Is Antibiotic Resistance Dangerous?

The biggest risk linked to these “superbugs” is that they are much harder to treat because standard antibiotics no longer work against them. Infections caused by resistant bacteria can lead to serious complications, including pneumonia and bloodstream infections, which can be life-threatening if not controlled quickly.

In a post shared on X, the UKHSA said: “Bacteria are evolving against antibiotics, with nearly 400 new resistant infections appearing each week in England.” NHS guidance has also warned that several bacteria have already developed resistance as a result of antibiotic overuse. These include MRSA, Clostridium difficile, and the bacteria linked to multidrug-resistant tuberculosis.

A major concern is that this growing trend could eventually lead to new strains of bacteria that cannot be treated with any existing antibiotics.

How To Reduce The Risk Of Antibiotic-Resistant Infections?

According to UKHSA advice, people can play a role in slowing the spread of resistant bacteria by following a few simple precautions in daily life. These include:

• Returning unused antibiotics to a pharmacy so they can be disposed of safely and do not contribute to resistance in the environment
• Practising safe sex, particularly to reduce the spread of infections such as gonorrhoea, which is becoming harder to treat
• Staying up to date with vaccinations, which can help prevent infections in the first place
• Talking to a healthcare professional before taking antibiotics, as they are not always necessary
• Washing hands thoroughly and staying at home when feeling unwell to avoid spreading infection

Many people rely on over-the-counter medicines, but a pharmacist has recently cautioned against the frequent use of some well-known remedies. Occasional indigestion or heartburn is common, but if these symptoms keep returning, there are important health points to be aware of to avoid creating bigger problems.

A pharmacist who goes by Pharmacist Anum on TikTok has shared a warning for people who regularly turn to these treatments. She explained that using certain medications too often can lead to complications, and said it is crucial for people to understand the risks before depending on them long term.

Health Warning For Taking Indigestion Medicines

This is not the first time she has offered such guidance. Only a few weeks earlier, she highlighted key concerns around taking excessive amounts of paracetamol. In her recent video, Pharmacist Anum said: “If you’re taking over-the-counter medicines without being properly checked, you could actually be doing more harm than good. The first group of medicines I’m talking about are those used for indigestion.

“Think about products like Gaviscon, Rennies, and esomeprazole. These are easy to buy over the counter in the UK and, for most people, they are safe when used for a short time.

“Problems arise when people start depending on them, taking them several times a week or even more often. If that sounds familiar, I would urge you to speak to your GP so they can look into what’s really causing your symptoms. Using these medicines too much can raise the risk of side effects and may also hide symptoms of a more serious issue.” In the same video, she also spoke about the risks linked to overusing common painkillers. She added that there are specific things people should understand about indigestion treatments.

What To Do If You Take Indigestion Medicines

Taking indigestion medicines too often, including antacids and proton pump inhibitors (PPIs), can conceal serious health problems and may lead to notable side effects. These can include kidney-related issues, such as stones or damage, as well as electrolyte imbalances, including low sodium or potassium levels.

Using the recommended dose for a short period is generally safe, but long-term use can interfere with normal digestion and may even lead to dependency. This is why it is important to seek medical advice if symptoms continue, so the underlying cause can be identified.

If you have been using these medications for an extended period, or even for years, it is important to speak with your doctor. A discussion about the risks and benefits can help determine whether there may be another health issue behind your symptoms.

What The NHS Says

According to the NHS website: “Always follow the instructions provided with Gaviscon or the guidance given by your doctor. The dose you need depends on the type of Gaviscon you are using.

“If you experience occasional mild heartburn or indigestion, take Gaviscon only when needed. If heartburn or indigestion is frequent, Gaviscon can be taken up to four times a day.

“The most effective times to take it are after meals and before bedtime, whether or not symptoms are present, as discomfort often worsens during these periods.

“If you have been taking Gaviscon for more than seven days and still feel uncomfortable or in pain, speak to your doctor. If you have used Gaviscon regularly over a long time, consult your doctor before stopping, as stopping suddenly may cause symptoms to return.” Further details are available on the NHS website.

Disclaimer: This article is for general information only and is not a substitute for professional medical advice, diagnosis, or treatment. Always follow the instructions on medication labels and consult a qualified healthcare professional or your GP before starting, stopping, or changing any medication. If symptoms persist, worsen, or recur frequently, seek medical advice promptly.