Most people are aware of type 1 and type 2 diabetes, but did you know there is a type 3 diabetes as well! It is a more obscure term. Although it is not an accepted medical diagnosis, type 3 diabetes has been discussed in the literature as a possible relationship between insulin resistance in the brain and Alzheimer's disease. This link has been described to help explain how metabolic disorders impact brain health, causing cognitive decline and dementia.

What is Type 3 Diabetes?

Type 3 diabetes is more of a misnomer because it should not be confused with type 3c diabetes, which relates to pancreatic dysfunction. The term "type 3 diabetes," on the other hand, has been loosely used by some scientists to analogously propose that Alzheimer's disease is strongly implicated with insulin resistance in the brain.

This concept was conceptualized by Dr. Suzanne de la Monte and Dr. Jack Wands of Brown University in the year 2008. This hypothesis postulated that Alzheimer's disease may be called type 3 diabetes for it bears many similarities with glucose metabolism disorder type 2 diabetes. Their concept arises from the basic principle that insulin is fundamental to blood sugar regulation, but it is also the case with the brain. When brain cells become insulin-resistant, they lose access to glucose, impairing their function.

Research published in the Journal of Diabetes Science and Technology supports this hypothesis by indicating that insulin resistance can be a significant contributor to the occurrence of dementia, also referred to as Alzheimer's. The symptoms of memory loss and diminished reasoning are associated with impaired glucose metabolism in the body, especially in the cerebral tissue.

Symptoms of Type 3 Diabetes

Although type 3 diabetes is not a "medical term," its symptoms correlate well with Alzheimer's diseases that are known to reduce the ability to think in an efficient manner and bring down brain health. These signs are:

- Loss of memory, especially short-term.

- Poor judgment and judgment ability

- Failure in recognizing people or places familiar once.

- Failure in the process of reading, writing or processing numbers

- Anxiety, agitation, or mood changes.

- Disorganized thoughts or confusion

- Lack of impulse control

As the disease advances, patients may be afflicted with severe complications including an inability to swallow or control their bodily functions. In the final stages, most patients die from fatal complications such as aspiration pneumonia.

Causes of Type 3 Diabetes

This may not be well understood with regards to type 3 diabetes, or the exact link between insulin resistance and Alzheimer's disease. Some identified contributing factors include the following:

1. Insulin Resistance

Insulin acts as an important regulatory mechanism of brain functions such as memory and cognition. The reduction in insulin signaling may impair metabolism of brain cells, thus bringing about neurodegeneration.

2. Type 2 Diabetes

These diseases show a strong relationship and those individuals diagnosed with type 2 diabetes have double chances of getting Alzheimer's. In the two, the main causes can be chronic inflammation, oxidative stress, and a defect in glucose metabolism.

3. Environmental and Lifestyle Factors

Insulin resistance associated with obesity, stress, and an unhealthy diet is considered a cause that may increase the chances of Alzheimer's disease.

Researches in Frontiers in Neuroscience and The Lancet Neurology have also highlighted that drugs used for antidiabetic medication may be crucial for the prevention or at least slowing down the course of Alzheimer's.

Treatments for Type 3 Diabetes

In 2022, in a study in Pharmaceuticals, researchers studied biomarker uptake in brain regions implicated in the faulty uptake and metabolism of blood sugar in Alzheimer’s patients.

Emerging Therapies

Research into such treatments as intranasal insulin has also been promising. Intranasal delivery of insulin directly to the brain has been reported to enhance glucose uptake by brain cells, improve memory, and boost cognitive performance. While such clinical trials have been shown to be successful, additional research is needed for safety and efficacy.

Medications

For patients being aggressive or agitated, antipsychotic drugs may be prescribed; however, therapies such as cognitive rehabilitation as well as cognitive stimulation therapy serve to preserve memory and executive function.

Lifestyle Interventions

Diet, exercise, and stress management are critical in preventing and managing insulin resistance. A review in the Journal of Alzheimer's Disease also highlighted the benefits of Kirtan Kriya meditation, which can regulate genes involved in insulin and glucose metabolism, improve sleep, and reduce inflammation.

Can Type 3 Diabetes Be Prevented?

Although type 3 diabetes is not officially recognized, its connection to Alzheimer’s disease underscores the importance of proactive measures for brain health. Some prevention strategies include:

1. Healthy Diet

Consuming a balanced diet rich in antioxidants, whole grains, and healthy fats may support brain health.

2. Regular Exercise

Physical activity improves insulin sensitivity, reduces inflammation, and enhances overall metabolic health.

3. Stress Reduction

Mindfulness practices, including meditation, have been shown to lower stress levels, which can reduce the risk of cognitive decline.

The term type 3 diabetes brings out the complex relationship between metabolic disorders and brain health. Even though it is not a recognized medical condition, the concept emphasizes the crucial role of insulin in brain function and its possible contribution to Alzheimer's disease. Continued research will hopefully provide hope for therapies such as intranasal insulin and lifestyle modifications.

Male infertility remains a topic rarely discussed, often overshadowed by social pressures and hesitation. Yet, it contributes to nearly half of all cases where couples struggle to conceive. Among the many causes, varicocele stands out as one of the most silent and underrecognised conditions, affecting a significant number of men in India.

With male reproductive health still a taboo, countless men remain unaware of their condition for years. Fertility tests often reveal the issue only after prolonged delays, adding emotional stress for couples. We got in touch with Dr. Suparna Bhattacharya, Fertility Specialist, Nova IVF Fertility, Kolkata, who told us more about the same.

What Is a Varicocele?

A varicocele occurs when the veins in the scrotum become enlarged, similar to varicose veins in the legs. These weakened, dilated veins disrupt blood flow to the testicles, causing a gradual rise in temperature that negatively affects sperm production and quality. Most men experience no pain, which is why the condition is often undetected, earning it the label of a “silent” problem. In many cases, it is discovered only during routine infertility evaluations.

Why It’s a Common Yet Ignored Cause of Male Infertility

Varicocele is particularly concerning because it often goes untreated, leading to more serious reproductive consequences. Dr. Suparna Bhattacharya said, “The condition may not produce noticeable symptoms—no pain, no swelling—yet internally, impaired blood flow and heat buildup gradually reduce sperm count, motility, and quality. Research shows varicocele accounts for a large proportion of male infertility cases, and the condition is largely reversible if identified early.”

A lack of awareness, coupled with the common misconception that infertility is primarily a female issue, often delays evaluation of the male partner. Many men only undergo semen analysis or scrotal ultrasound after significant time has passed.

Can Surgery Restore Fertility?

The encouraging news is that varicocele is one of the few male infertility issues that can be effectively treated with surgery. Varicocelectomy, the most common procedure, involves tying off the affected veins while preserving normal blood flow. This helps cool the scrotum and allows sperm production to return to healthier levels.

Dr. Suparna Bhattacharya told us that post-surgery, many men experience notable improvements in sperm count and motility within six months. For couples, this can mean natural conception without advanced fertility treatments. Correcting varicocele can also improve sperm DNA integrity, enhancing the success rates of procedures like IVF or ICSI.

Potential Consequences of Untreated Varicocele

Not all varicoceles require surgery, especially if mild or asymptomatic. However, undetected or significant varicoceles can progressively impair sperm quality and, in some cases, lead to testicular atrophy. Delayed diagnosis can reduce the likelihood of natural conception as men age.

When Should You See a Doctor?

Men who have been trying to conceive for over a year should undergo a comprehensive fertility check-up. A simple semen analysis and physical examination are often sufficient to detect most varicoceles. “Early intervention is crucial, particularly for those hoping for natural conception or planning to start a family,” said Dr. Suparna Bhattacharya

Promoting awareness about male reproductive health is just as important as educating women on fertility. Varicocele is a silent, yet easily treatable, condition. Timely diagnosis and treatment can restore fertility and reduce the emotional and financial strain on couples. The first step toward healthier, happier families is acknowledging the issue, seeking treatment, and discussing it openly.

Anyone who relies on ibuprofen, naproxen or ordinary-strength aspirin for pain or arthritis has been advised to be cautious, after an NHS doctor raised concerns about the risks of long-term use. Dr Mark Porter, a GP known for his appearances on The One Show, said many people do not realise these medicines can lead to stomach ulcers and internal bleeding.

He noted that bleeding in the stomach or upper gut is a serious medical emergency. An audit led by researchers at the University of Oxford shows that this type of bleeding leads to at least 60,000 hospital admissions each year, and about one in ten patients does not survive to return home.

NHS Doctors Issue Warning for Anyone Using Ibuprofen, Naproxen or Aspirin

Dr Porter referenced a report published in the journal Gut, which compared outcomes from 2007 and 2022. The data revealed how many people who suffered gut bleeds were taking medicines, both prescribed and over the counter, that could trigger or worsen the problem.

As per Times,, he said that nearly half of the 5,141 patients analysed in the audit had been taking some type of drug that increases the chance of bleeding. These included low-dose aspirin, clopidogrel and anticoagulants such as warfarin and apixaban. In addition, one in fourteen patients had been using a non-steroidal anti-inflammatory drug (NSAID) like ibuprofen, naproxen or normal-dose aspirin, which are commonly used to relieve pain and treat arthritis.

Why NSAIDs Can Be More Dangerous Than People Realise

Dr Porter said many people who take low-dose aspirin or blood thinners to lower the risk of stroke, heart attack or blood clots know that these medicines carry a bleeding risk. The concern is that far fewer people understand that NSAIDs can be just as harmful for some individuals. According to him, NSAIDs are responsible for about a third of all NHS hospital admissions linked to adverse drug reactions. These admissions take up roughly one in five hospital beds. Beyond gut bleeding, NSAIDs can also raise the chance of heart attacks, strokes and kidney problems.

Stomach Symptoms Can Worsen With Long-Term Use

People who already struggle with heartburn or indigestion often notice that occasional ibuprofen or aspirin makes their symptoms worse. Dr Porter explained that, when taken frequently or over long periods, these medicines can do much more damage. Their effect on prostaglandins, which helps ease pain, also weakens the stomach’s natural defences against its own acids. This can lead to irritation, ulcers, bleeding and in some cases, a perforation.

He added that although the overall risk for most people is small, doctors have become more aware of these dangers. As a result, NSAID use has fallen in many countries over the past 25 years. Even so, these drugs are still widely prescribed, especially for older adults. Some estimates suggest that nearly one in five people over 65 has taken at least one course in the past year.

Why Protective Medicines Do Not Remove All Risks

Doctors often prescribe antacid medicines such as omeprazole alongside stronger NSAIDs like naproxen to help protect the stomach. Dr Porter clarified that these medicines lower the risk of bleeding, but they do not remove it fully. He said certain groups should be particularly careful.

These include people on low-dose aspirin or similar drugs like clopidogrel, anyone taking anticoagulants such as warfarin or apixaban, those who often have indigestion or heartburn, anyone with a history of stomach or duodenal ulcers, people living with heart failure or chronic kidney disease, and adults over 65 who are not taking stomach-protective medication.

Aspirin Should Not Be Taken Casually

Dr Porter added that one painkiller should never be taken without a doctor’s instruction. He said he would avoid using aspirin for day-to-day discomfort unless advised by a medical professional. For issues such as a hangover, a headache or a sore knee, paracetamol is usually safer than ibuprofen, although it may not offer the same level of relief. An occasional NSAID is unlikely to cause harm for most people, as long as they are not in a high-risk group. However, anyone who needs pain relief often, whether daily or several times a week, should speak to their GP to decide on a safer plan.

Dr Porter offered one final piece of advice. While vomiting blood is an obvious emergency, an earlier sign of slow bleeding in the upper gut can be easy to miss. Black, tar-like stools, known as melena, should never be ignored. Anyone who notices this should seek medical help without delay.

Blood pressure shifts throughout the day in a steady rhythm shaped by hormones, activity, and the body’s internal clock. Doctors call this the circadian pattern of blood pressure. It helps the body prepare for wakefulness, support daytime tasks, and recover during sleep.

While this rise and fall is normal, the timing of these changes matters, especially for people with hypertension or heart conditions. Dr Sunil Rana, Associate Director and Head of Internal Medicine (Unit III), Asian Hospital, explains how these variations unfold across a typical day.

Why Blood Pressure Peaks in the Early Morning

In a normal cycle, the highest readings appear between six in the morning and nine in the morning. This is the point when the body shifts from sleep to wakefulness. Hormones such as cortisol and adrenaline surge during these hours. They raise the heart rate and tighten blood vessels to help the body feel alert.

Dr Sunil Rana said, “This rise is natural, yet it carries added importance for people with hypertension, diabetes, sleep disorders, or heart disease. During these early hours, the risk of heart attack, stroke, and other vascular complications is known to be higher because the body is under greater strain.”

How Daytime Habits Shape Midday and Afternoon Readings

After the morning peak, blood pressure usually settles into a moderate range through the late morning and early afternoon. Daily tasks like walking, working, travel, and problem-solving maintain a steady level. At the same time, several routine triggers can push these numbers higher. Mental stress, dehydration, caffeine, skipped meals, and long periods of sitting often raise readings through the day.

Dr Sunil Rana, told us that people who face chronic stress, irregular work hours, or disrupted eating patterns tend to see wider swings. Toward late afternoon, blood pressure usually dips slightly as the body begins to wind down. However, heavy meals, alcohol, emotional tension, or intense workouts in the evening can cause short-lived spikes.

Why Blood Pressure Falls at Night?

During sleep, the body enters a quieter phase known as nocturnal dipping, where blood pressure typically drops by ten to twenty percent. This drop gives the heart and blood vessels a chance to rest. The dip is an important part of cardiovascular recovery.

Dr Sunil Rana said, “Not everyone experiences this nightly reduction. People with kidney disease, diabetes, sleep apnea, or autonomic dysfunction may show little or no dip at night, which is linked to a greater risk of long-term heart problems. Irregular sleep routines, late-night screen use, and chronic insomnia can also disrupt this natural decline and keep nighttime readings higher than expected.”

Factors That Influence These Daily Changes

The steepness of these fluctuations differs from person to person. Age, lifestyle, food habits, alcohol, smoking, weight, and stress all play a part. Night-shift workers may show the reverse pattern, with pressure rising at night instead of morning. Medication timing also shapes the curve, especially in people who take antihypertensive drugs.

Doctors often advise checking blood pressure at different times of the day, including early morning and before bedtime, to understand a person’s individual rhythm more clearly.

Understanding that blood pressure is naturally highest in the early morning helps in planning treatment and daily routines. It guides medication timing, supports healthier morning habits, and strengthens long-term control. It also helps people at higher risk take steps to protect their heart during the hours when it needs the most support.