What Is Type 3 Diabetes? Insulin Resistance In The Brain That Could Trigger Alzheimer’s

Updated Dec 3, 2024 | 06:13 PM IST

SummaryDid you know type 3 diabetes, linked to insulin resistance in the brain, is associated with Alzheimer’s disease? It highlights how metabolic disorders can affect memory, cognition, and brain health.
What Is Type 3 Diabetes? Insulin Resistance In The Brain That Could Trigger Alzheimer’s

What Is Type 3 Diabetes? Insulin Resistance In The Brain That Could Trigger Alzheimer’s

Most people are aware of type 1 and type 2 diabetes, but did you know there is a type 3 diabetes as well! It is a more obscure term. Although it is not an accepted medical diagnosis, type 3 diabetes has been discussed in the literature as a possible relationship between insulin resistance in the brain and Alzheimer's disease. This link has been described to help explain how metabolic disorders impact brain health, causing cognitive decline and dementia.

What is Type 3 Diabetes?

Type 3 diabetes is more of a misnomer because it should not be confused with type 3c diabetes, which relates to pancreatic dysfunction. The term "type 3 diabetes," on the other hand, has been loosely used by some scientists to analogously propose that Alzheimer's disease is strongly implicated with insulin resistance in the brain.

This concept was conceptualized by Dr. Suzanne de la Monte and Dr. Jack Wands of Brown University in the year 2008. This hypothesis postulated that Alzheimer's disease may be called type 3 diabetes for it bears many similarities with glucose metabolism disorder type 2 diabetes. Their concept arises from the basic principle that insulin is fundamental to blood sugar regulation, but it is also the case with the brain. When brain cells become insulin-resistant, they lose access to glucose, impairing their function.

Research published in the Journal of Diabetes Science and Technology supports this hypothesis by indicating that insulin resistance can be a significant contributor to the occurrence of dementia, also referred to as Alzheimer's. The symptoms of memory loss and diminished reasoning are associated with impaired glucose metabolism in the body, especially in the cerebral tissue.

Symptoms of Type 3 Diabetes

Although type 3 diabetes is not a "medical term," its symptoms correlate well with Alzheimer's diseases that are known to reduce the ability to think in an efficient manner and bring down brain health. These signs are:

- Loss of memory, especially short-term.

- Poor judgment and judgment ability

- Failure in recognizing people or places familiar once.

- Failure in the process of reading, writing or processing numbers

- Anxiety, agitation, or mood changes.

- Disorganized thoughts or confusion

- Lack of impulse control

As the disease advances, patients may be afflicted with severe complications including an inability to swallow or control their bodily functions. In the final stages, most patients die from fatal complications such as aspiration pneumonia.

Causes of Type 3 Diabetes

This may not be well understood with regards to type 3 diabetes, or the exact link between insulin resistance and Alzheimer's disease. Some identified contributing factors include the following:

1. Insulin Resistance

Insulin acts as an important regulatory mechanism of brain functions such as memory and cognition. The reduction in insulin signaling may impair metabolism of brain cells, thus bringing about neurodegeneration.

2. Type 2 Diabetes

These diseases show a strong relationship and those individuals diagnosed with type 2 diabetes have double chances of getting Alzheimer's. In the two, the main causes can be chronic inflammation, oxidative stress, and a defect in glucose metabolism.

3. Environmental and Lifestyle Factors

Insulin resistance associated with obesity, stress, and an unhealthy diet is considered a cause that may increase the chances of Alzheimer's disease.

Researches in Frontiers in Neuroscience and The Lancet Neurology have also highlighted that drugs used for antidiabetic medication may be crucial for the prevention or at least slowing down the course of Alzheimer's.

Treatments for Type 3 Diabetes

In 2022, in a study in Pharmaceuticals, researchers studied biomarker uptake in brain regions implicated in the faulty uptake and metabolism of blood sugar in Alzheimer’s patients.

Emerging Therapies

Research into such treatments as intranasal insulin has also been promising. Intranasal delivery of insulin directly to the brain has been reported to enhance glucose uptake by brain cells, improve memory, and boost cognitive performance. While such clinical trials have been shown to be successful, additional research is needed for safety and efficacy.

Medications

For patients being aggressive or agitated, antipsychotic drugs may be prescribed; however, therapies such as cognitive rehabilitation as well as cognitive stimulation therapy serve to preserve memory and executive function.

Lifestyle Interventions

Diet, exercise, and stress management are critical in preventing and managing insulin resistance. A review in the Journal of Alzheimer's Disease also highlighted the benefits of Kirtan Kriya meditation, which can regulate genes involved in insulin and glucose metabolism, improve sleep, and reduce inflammation.

Can Type 3 Diabetes Be Prevented?

Although type 3 diabetes is not officially recognized, its connection to Alzheimer’s disease underscores the importance of proactive measures for brain health. Some prevention strategies include:

1. Healthy Diet

Consuming a balanced diet rich in antioxidants, whole grains, and healthy fats may support brain health.

2. Regular Exercise

Physical activity improves insulin sensitivity, reduces inflammation, and enhances overall metabolic health.

3. Stress Reduction

Mindfulness practices, including meditation, have been shown to lower stress levels, which can reduce the risk of cognitive decline.

The term type 3 diabetes brings out the complex relationship between metabolic disorders and brain health. Even though it is not a recognized medical condition, the concept emphasizes the crucial role of insulin in brain function and its possible contribution to Alzheimer's disease. Continued research will hopefully provide hope for therapies such as intranasal insulin and lifestyle modifications.

End of Article

Ebola Outbreak: Why African Countries Are Disproportionately Impacted By The Disease?

Updated Sep 17, 2025 | 11:42 AM IST

SummaryEbola persists as an endemic in parts of Africa due to more than its pathology, it thrives on fragile health systems, resource shortages, poor medical staffing, and deep community distrust rooted in conflict. Unlike wealthier nations with strong infrastructure, these regions face recurring outbreaks, where systemic gaps turn crises into catastrophes.
Ebola Outbreak: Why African Countries Are Disproportionately Impacted By The Disease?

Credits: Canva

The recent outbreak of Ebola Virus Disease, with confirmed 81 cases have brought this question again to the world: Why are African countries disproportionately impacted by Ebola Outbreaks?

The Ebola Virus Disease (EVD) outbreaks have periodically occurred in affected regions of West and sub-Saharan Africa since the emergence of EVD in 1976. It continues to remain endemic in these regions to this day, whereas, it has been eradicated from other areas.

To understand why certain regions are disproportionately impacted, we must understand these followings.

Pathology Of The Virus

Ebola’s incubation period can last from 2 to 21 days, but transmission begins only when symptoms appear. Once it strikes, the disease moves swiftly. Without supportive care, like IV fluids, antibiotics, dialysis, or specialized infection control, the fatality rate can soar up to 70% in places like Liberia, Sierra Leone, and Guinea. Compare that to the 2014 Ebola scare in the United States: nine cases, just one death, and zero spread beyond the initial outbreak. The contrast underscores a painful truth, Ebola is not only a medical problem but also a systemic one.

The Lack Of Resources

In countries like the US, hospitals are equipped with rehydration tools, multiple blood pressure medications, and well-trained doctors. They also have strict infection control systems to prevent the disease from moving beyond hospital walls.

In contrast, in many West African facilities, even the most basic supplies can run out. During the 2014 West Africa outbreak, some hospitals stocked just one type of blood pressure drug, hardly enough to save lives when patients’ bodies responded differently.

Also Read: Ebola Outbreak Update: Vaccines Continue To Arrive As Congo Yet Again Becomes Disease Hotspot

The disparity in staffing is equally grim. The US has about 245 doctors for every 100,000 people. Liberia, Sierra Leone, and Guinea? Just 1.4, 2.2, and 10 per 100,000, respectively, notes University of Michigan's School of Public Health. In a disease outbreak where immediate and skilled intervention can mean the difference between containment and chaos, this shortage is devastating.

Violence and Distrust: The Invisible Enemy

But Ebola doesn’t just thrive on weak health systems, it feeds on broken trust. Many African nations hardest hit by Ebola have been scarred by years of civil conflict. Public health systems, roads, and communications were already fragile before the virus appeared. In Sierra Leone, Guinea, and Liberia, the memory of political violence and neglect fueled deep distrust of governments and outsiders.

During the 2014–2016 epidemic, attacks on doctors and aid workers became common. Rumors spread faster than the virus: some communities believed Ebola was a foreign invention, others feared that medical workers were spreading it deliberately. When burial traditions, like washing and touching the dead, were discouraged by officials, resistance turned violent, noted the report by University of Michigan. Cultural clashes and misinformation made every effort to contain the disease harder, often putting lives at even greater risk.

Why Ebola Persists

Ebola remains endemic in parts of Africa because it is more than a virus, it’s a reflection of the gaps in public health, governance, and community trust. The combination of limited resources, dangerously low numbers of medical staff, fragile infrastructures, and deep-seated distrust creates a cycle where each outbreak threatens to become a catastrophe.

Until these systems are rebuilt, hospitals resourced, communities engaged, and trust restored, Ebola will continue to lurk, waiting for its next chance to reemerge.

End of Article

What Is Babesia That Could Block Your Lyme Disease Recovery?

Updated Sep 17, 2025 | 11:26 AM IST

SummaryA Lyme disease look-alike and spread by the same tick, but this could be the reason why your Lyme disease is not recovering. It may not be Lyme disease to begin with, it could be Babesia. What is it? How is it different from Lyme disease? How can one treat it? All answers lie here. Read on.
What Is Babesia That Could Block Your Lyme Disease Recovery?

Credits: Canva

Lyme disease is often described as a medical puzzle. Many patients expect recovery after treatment, but for some, lingering symptoms like fatigue, sweats, palpitations, or breathing difficulties, continue to disrupt daily life. Increasingly, researchers and practitioners are recognizing that a hidden co-infection may be responsible: Babesia.

Though transmitted by the same ticks that spread Lyme disease, Babesia is a parasite rather than a bacterium. This means that while standard antibiotics for Lyme may clear Borrelia burgdorferi (the Lyme-causing bacteria), they do not affect Babesia. If left untreated, the infection can stall or even derail recovery.

What Is Babesia?

Alexis Chesney, MS, ND, LAc, who is also a naturopathic physician, acupuncturist, author, and educator specializing in Lyme and vector-borne disease, writes that Babesia is a malaria-like parasite that invades red blood cells, belonging to the phylum Apicomplexa.

Also Read: Ebola Outbreak Update: Vaccines Continue To Arrive As Congo Yet Again Becomes Disease Hotspot

First described in the late 19th century, it has since been identified in multiple species, with Babesia microti and Babesia duncani being most common in the U.S. The Centers for Disease Control and Prevention (CDC) recently reported a rise in cases across the Northeast and upper Midwest, even declaring Vermont, New Hampshire, and Maine as endemic states.

The parasite is transmitted by the blacklegged tick (Ixodes scapularis) in the East and Midwest, and Ixodes pacificus in the West. Transmission can occur within 36 hours of tick attachment, making timely removal critical.

How Babesia Blocks Lyme Recovery

Lyme disease is caused by bacteria, while Babesia is a protozoan parasite. The difference is crucial: antibiotics like doxycycline or ceftriaxone, typically prescribed for Lyme, have no effect on Babesia. When this parasitic infection is overlooked, patients often remain sick despite completing Lyme treatment.

This overlap of infections is common in regions where both pathogens circulate. Patients coinfected with Babesia and Lyme may experience a tougher, more prolonged illness, with night sweats, air hunger (difficulty breathing at rest), and palpitations serving as hallmark clues that Lyme alone isn’t to blame.

Symptoms to Watch

Babesia symptoms can vary widely, from mild to life-threatening. Common complaints include:

  • Excessive sweating or night sweats
  • Crushing fatigue
  • Shortness of breath or “air hunger”
  • Heart palpitations or chest pain
  • Headaches and joint aches

In severe cases, particularly in older adults, immunocompromised individuals, or those without a spleen, Babesia may cause hemolytic anemia, kidney problems, and organ stress.

Diagnosis

Because symptoms overlap with Lyme disease, Babesia often goes undiagnosed without specific testing. Traditional options include:

Blood smear (Giemsa-stained): A classic but limited method, as only a tiny fraction of red blood cells may show parasites in early or chronic cases.

PCR testing: Detects Babesia DNA with high sensitivity in acute infections.

FISH (fluorescence in situ hybridization): A more advanced method that detects Babesia RNA, distinguishing between live and dead parasites and proving especially valuable in chronic disease.

Accurate testing is critical, as untreated Babesia can persist and block progress against Lyme.

Treatment Approaches

Conventional treatment generally involves a combination of atovaquone and azithromycin for 7–10 days in mild to moderate cases. More severe or persistent infections may require longer regimens, sometimes with alternative drugs like clindamycin and quinine. However, treatment failures and drug resistance have been reported.

Naturopathic and integrative therapies are increasingly used alongside pharmaceuticals. Herbs such as Cryptolepis sanguinolenta, Artemisia annua (Sweet Annie), Polygonum cuspidatum (Japanese Knotweed), and Scutellaria baicalensis (Chinese skullcap) have shown anti-Babesia activity in laboratory studies. These botanicals not only target parasites but also support the immune system, reduce inflammation, and protect red blood cells.

Some practitioners also use anti-biofilm agents like serrapeptase or lumbrokinase to break down protective barriers that Babesia forms, making antimicrobial treatment more effective.

Why Awareness Matters

As Babesia spreads to new geographic regions, it is critical for healthcare providers to recognize its role in chronic illness. Ignoring Babesia may leave patients trapped in a cycle of incomplete Lyme recovery, chasing symptoms without lasting relief. A thorough approach that screens for co-infections and treats them comprehensively is essential.

For patients struggling with ongoing fatigue, sweats, or unexplained heart and lung symptoms after Lyme treatment, the missing piece could be Babesia. Recognizing and addressing this stealth parasite may be the key to finally breaking through to recovery.

End of Article

Cleaning VS Smoking: What Is Worse For Your Lungs? Study Reveals The Surprising Answer To Declining Lung Function

Updated Sep 17, 2025 | 05:00 AM IST

SummaryCleaning is not just to make sure that your space looks presentable, it is also about your health. Our parents taught us to clean our personal spaces to ensure we remain healthy. But what if the healthy habit is the reason behind our health decline? A study shows cleaning may be detrimental to your lungs
Cleaning VS Smoking: What Is Worse For Your Lungs? Study Reveals The Surprising Answer To Declining Lung Function

Smoking is one of the leading causes for lung diseases for people, but did you know a simple hygiene habit could actually be worse than that? While cleaning is a necessary part of your home and living, could cleaning be the reason behind your declining lung health?

A 2018 study from Norway published in the American Thoracic Society's American Journal of Respiratory and Critical Care Medicine, suggests that the answer is yes, especially for women. Scientists followed over 6,000 people for 20 years and found that regular exposure to common cleaning products can be very harmful to their lungs.

The study compared the decline in lung function among women who cleaned regularly—at least once a week—to that of women who did not. The results were shocking: the damage was so significant that it was like smoking a pack of cigarettes every day for 20 years. Interestingly, the researchers did not find the same negative effects on men in the study.

What Cleaning Products Are Causing Harm To Your Lungs?

The study found that women who regularly cleaned, whether at home or as a job, had a faster decline in their lung function compared to women who didn't clean. This decline was measured by how much air they could breathe out in one second.

The main culprits are harsh cleaning chemicals like ammonia and bleach. These chemicals can irritate and damage the delicate lining inside your airways. Over time, this damage can lead to serious health problems such as asthma, chronic airway obstruction (which makes it hard to breathe), and long-term inflammation.

According to cancer experts at Moffitt Cancer Center, this type of continuous inflammation could even cause changes in your cells that might increase your risk for cancer.

Scientists believe the decline in lung function is caused by the irritation that most cleaning chemicals create in the airways. Over time, this constant irritation can lead to permanent changes in the lungs. The study also found that women who cleaned regularly were more likely to have asthma. Interestingly, this negative effect was not seen in men who participated in the study.

Simple Changes for Safer Cleaning

The good news is that you can protect yourself by making a few simple changes to how you clean. According to the Moffitt Cancer Center, you can incorporate these tips while cleaning.

Go Natural

Whenever you can, choose natural cleaning products instead of harsh chemicals. A simple mix of vinegar and water works great for many surfaces. For tough scrubbing jobs, use everyday items you already have, like salt or a steel wool pad, to get the job done safely.

Wear a Mask

Protect your lungs from harmful fumes by wearing a mask while you clean. A mask helps filter out tiny particles from cleaning sprays and powders, so you don’t breathe them in. This is a simple but very effective step to keep your airways healthy.

Ventilate the Area

Always make sure to open windows and doors when you're cleaning. Letting fresh air in helps push chemical fumes and other pollutants out of your home. This prevents them from building up in the air you're breathing and reduces the health risks associated with them.

End of Article