What Is Type 3 Diabetes? Insulin Resistance In The Brain That Could Trigger Alzheimer’s
Most people are aware of type 1 and type 2 diabetes, but did you know there is a type 3 diabetes as well! It is a more obscure term. Although it is not an accepted medical diagnosis, type 3 diabetes has been discussed in the literature as a possible relationship between insulin resistance in the brain and Alzheimer's disease. This link has been described to help explain how metabolic disorders impact brain health, causing cognitive decline and dementia.
Type 3 diabetes is more of a misnomer because it should not be confused with type 3c diabetes, which relates to pancreatic dysfunction. The term "type 3 diabetes," on the other hand, has been loosely used by some scientists to analogously propose that Alzheimer's disease is strongly implicated with insulin resistance in the brain.
This concept was conceptualized by Dr. Suzanne de la Monte and Dr. Jack Wands of Brown University in the year 2008. This hypothesis postulated that Alzheimer's disease may be called type 3 diabetes for it bears many similarities with glucose metabolism disorder type 2 diabetes. Their concept arises from the basic principle that insulin is fundamental to blood sugar regulation, but it is also the case with the brain. When brain cells become insulin-resistant, they lose access to glucose, impairing their function.
Research published in the Journal of Diabetes Science and Technology supports this hypothesis by indicating that insulin resistance can be a significant contributor to the occurrence of dementia, also referred to as Alzheimer's. The symptoms of memory loss and diminished reasoning are associated with impaired glucose metabolism in the body, especially in the cerebral tissue.
Although type 3 diabetes is not a "medical term," its symptoms correlate well with Alzheimer's diseases that are known to reduce the ability to think in an efficient manner and bring down brain health. These signs are:
- Loss of memory, especially short-term.
- Poor judgment and judgment ability
- Failure in recognizing people or places familiar once.
- Failure in the process of reading, writing or processing numbers
- Anxiety, agitation, or mood changes.
- Disorganized thoughts or confusion
- Lack of impulse control
As the disease advances, patients may be afflicted with severe complications including an inability to swallow or control their bodily functions. In the final stages, most patients die from fatal complications such as aspiration pneumonia.
This may not be well understood with regards to type 3 diabetes, or the exact link between insulin resistance and Alzheimer's disease. Some identified contributing factors include the following:
Insulin acts as an important regulatory mechanism of brain functions such as memory and cognition. The reduction in insulin signaling may impair metabolism of brain cells, thus bringing about neurodegeneration.
These diseases show a strong relationship and those individuals diagnosed with type 2 diabetes have double chances of getting Alzheimer's. In the two, the main causes can be chronic inflammation, oxidative stress, and a defect in glucose metabolism.
Insulin resistance associated with obesity, stress, and an unhealthy diet is considered a cause that may increase the chances of Alzheimer's disease.
Researches in Frontiers in Neuroscience and The Lancet Neurology have also highlighted that drugs used for antidiabetic medication may be crucial for the prevention or at least slowing down the course of Alzheimer's.
In 2022, in a study in Pharmaceuticals, researchers studied biomarker uptake in brain regions implicated in the faulty uptake and metabolism of blood sugar in Alzheimer’s patients.
Emerging Therapies
Research into such treatments as intranasal insulin has also been promising. Intranasal delivery of insulin directly to the brain has been reported to enhance glucose uptake by brain cells, improve memory, and boost cognitive performance. While such clinical trials have been shown to be successful, additional research is needed for safety and efficacy.
Medications
For patients being aggressive or agitated, antipsychotic drugs may be prescribed; however, therapies such as cognitive rehabilitation as well as cognitive stimulation therapy serve to preserve memory and executive function.
Lifestyle Interventions
Diet, exercise, and stress management are critical in preventing and managing insulin resistance. A review in the Journal of Alzheimer's Disease also highlighted the benefits of Kirtan Kriya meditation, which can regulate genes involved in insulin and glucose metabolism, improve sleep, and reduce inflammation.
Although type 3 diabetes is not officially recognized, its connection to Alzheimer’s disease underscores the importance of proactive measures for brain health. Some prevention strategies include:
1. Healthy Diet
Consuming a balanced diet rich in antioxidants, whole grains, and healthy fats may support brain health.
2. Regular Exercise
Physical activity improves insulin sensitivity, reduces inflammation, and enhances overall metabolic health.
3. Stress Reduction
Mindfulness practices, including meditation, have been shown to lower stress levels, which can reduce the risk of cognitive decline.
The term type 3 diabetes brings out the complex relationship between metabolic disorders and brain health. Even though it is not a recognized medical condition, the concept emphasizes the crucial role of insulin in brain function and its possible contribution to Alzheimer's disease. Continued research will hopefully provide hope for therapies such as intranasal insulin and lifestyle modifications.
Credits: WWE
We have all heard about the benefits of using sunscreens, but how many of us actually follow it through? Especially among the men, there is a conventional belief that anything on their skin is not manly enough. But, what if I tell you that even someone as strong as John Cena recommends everyone to wear sunscreen? Would you still choose to not use it?
John Cena, actor and the WWE star has recently opened up about a past skin cancer diagnosis in an effort to bring attention to the important of wearing sunscreen. He told People that he grew up in Massachusetts in the 1970s and 80s, and "never" wore sunscreen. It was later in life when he moved to Florida, and there he "fell in love with the sun", but "neglected" to protect his skin and use sunscreen.
“I was stubborn. I didn’t want to have a routine and I also thought the problem would never reach me. And it’s one of those things where I had a ton of exposure with minimal protection and it caught up with me,” said Cena.
It was during one of his routine check-ups that made Cena to re-think to use sunscreen. “It wasn’t until I went to a dermatologist and got a skin checkup and had a cancerous spot removed from my right pec,” he said.
Cena is now also the face of a sunscreen brand with SPF 70. He revealed that he was "very lucky" to have a good dermatologist who help him face his fear around his diagnosis.
After the removal of first cancerous spot on Cena's chest, there was another. "A year later, I went back and had another spot removed close to my right shoulder. It shows up like a white polka dot on the side of my chest and on my shoulder. If you watch WWE, you’ll be able to see them," he said.
It was a shock to him, because he never saw being diagnosed with skin cancer coming. "Mind always goes to the worst case scenario," he said. However, it was the diagnosis that allow him to understand the importance of sunscreen that protects one's skin from sun's rays.
“I’m at a great space in my life where that’s now important to me. And I’m so grateful to be able to dodge those two bullets, but I wear them as a reminder of, ‘Hey man, you need to take the extra few seconds to protect yourself every day,’” he said.
ALSO READ: Does Sunscreen Block Your Body's Natural Vitamin D Production?
As per the Johns Hopkins Medicine, wearing sunscreen is the easiest and the best ways to protect your skin's appearance and health at any age. It recommends to use it regularly to prevent sunburn, skin cancer, and premature aging.
While everyone needs sun exposure to produce vitamin D, unprotected exposure to the sun's UV rays can cause damage to the eyes, skin, and the immune system.
To protect, apply 1 ounce of sunscreen throughout your body. To protect your face and neck, you will need about half a teaspoon of sunscreen.
Experts also believe that as long as the sunscreen is at least SPF 30 and is water-resistant, it does not matter what order you apply your skin care products. While some people find it is easiest to work with bare skin, some do it at the end.
"If you’re out there and you brush your teeth, at a young age you learned that going to the dentist when your teeth are in bad shape is bad because it’s painful. The same thing will happen if you don’t take care of your skin, and it’s actually easier than brushing your teeth. Because it’s not something you should exercise to just make you look more beautiful,” Cena said.
“It’s something you should exercise to allow you to be who you are for a longer period of time.”
(Credit-Canva)
Just as your habits say a lot about you, the way you sleep also shows a part of you. Everyone has their own way of sleeping, whether it is sleeping on their belly, or being in the habit of needing space when they sleep etc. However, there's a less common position that's been named after a dinosaur: the "T-rex." Imagine a T-rex with its tiny arms pulled close to its chest; that's the position we're talking about. People who sleep this way bend their wrists and bring their hands near their body. It might look a little funny, but for them, it's the most comfortable way to fall asleep and stay asleep all night long.
Experts also believe that when you bend your wrists and bring them close, you're actually relaxing some of the muscles in your arms and hands. Think of it like a gentle hug for your own body. When your arms are straight, those muscles are a little tense. However, when you bend them, they relax, which can feel really good, especially when you're trying to fall asleep. While there is no substantial evidence of how the T-rex position affects your behavior, a similar sleeping position, which is the fetal position, is said to be comforting with arms and feet drawn close to chest like a fetus in the womb. The Sleep Foundation tells that over 60% of adults sleep in this position. It was also hypothesized that people who sleep this way are more anxious and emotional.
Sleeping with your wrists bent all night can cause problems. Mayo Clinic explains that your wrists have nerves, arteries, and tendons running through them, and when you bend them for too long, you put pressure on these delicate structures. This pressure can lead to aches and pains in your wrists and even your elbows. You might also feel numbness or tingling in your hands. If you keep sleeping this way night after night, you could develop conditions like carpal tunnel syndrome or tendonitis, which are painful and can make it hard to use your hands. So, while it's comfy, it's important to be aware of the potential issues.
Completely eliminating a comfortable sleeping position can be challenging. Instead, focus on mitigating the potential problems. Here are some strategies as per WebMD
Using a body pillow can provide a sense of security and reduce the need to tuck your arms tightly. Weighted blankets can help alleviate anxiety and promote relaxation, potentially lessening the urge for the T-rex position.
Practicing meditation and deep breathing techniques can help manage stress and reduce the likelihood of reverting to the T-rex position. Taking a few minutes to relax and breathe deeply before bed can make a big difference. These practices can help you unwind and prepare for a restful night.
Regularly stretching your wrists and arms in the opposite direction of the bent position each morning can help alleviate pain and numbness. Simple stretches, like rotating your wrists or extending your arms, can help improve flexibility and reduce discomfort. Doing these stretches regularly can prevent long-term problems and keep your wrists healthy and strong.
Image Credits: Canva
World Autism Awareness Day commemorates the period set aside to develop insight and promote solutions for those with autism spectrum disorder (ASD). Although the classic therapies of applied behavior analysis (ABA), speech therapy, and occupational therapy have been the standard intervention for autism, there has been an increasing interest in a different method: play therapy. Advoctates purport that play therapy stimulates a child's intrinsic method of acquiring knowledge, supporting communication, interpersonal skills, and emotional balance more effectively than can often be provided by mainstream interventions. Is play therapy the secret ingredient of autism intervention?
Autism Spectrum Disorder (ASD) impacts a child's capacity to communicate, socialize, and use imaginative play. Compared to neurotypical children, autistic children tend to have difficulties with pretend play and usually have a strong interest in particular activities. With these difficulties in mind, therapeutic interventions that address their needs are highly important. One of these interventions is play therapy, which is a structured but fun means of helping autistic children acquire vital life skills.
Play is the language of children, being a universal way of communication and learning. The Association for Play Therapy (APT) describes play therapy as the "systematic use of a theoretical model to establish an interpersonal process wherein trained play therapists use the therapeutic powers of play to help clients prevent or resolve psychosocial difficulties and achieve optimal growth and development." (APT, 2021).
In autistic children, play therapy provides a fun and organized setting to understand feelings, rehearse social interactions, and improve communication. A professional therapist helps the child progress through play-based strategies that promote self-expression and establish healthy relationships with parents, siblings, and friends.
Play therapy is especially effective for children with ASD because it works within their natural learning and interaction style. It offers a low-stress, safe space in which children can:
Because autistic children tend to interact with play differently—e.g., becoming fixated on the components of a toy instead of the object as a whole or having difficulty with pretend play—therapists employ systematic methods to enable them to connect with their environment and the individuals in it.
Play therapy involves a variety of methods adapted to a child's individual needs. Some of the most useful types for autistic children are:
CCPT emphasizes establishing a nonjudgmental and accepting environment in which children are able to express themselves spontaneously. The therapist becomes the facilitator, with the child selecting activities of play while being treated with empathy and acceptance. This creates an atmosphere of safety and trust, with children able to explore their emotions and build up social skills organically.
Unlike CCPT, structured play therapy involves specific activities designed to target particular developmental goals. These sessions help autistic children develop essential skills in a step-by-step manner, ensuring they feel comfortable and supported.
CBPT is an integration of cognitive behavioral therapy (CBT) with play therapy to assist children in identifying and managing their emotions. CBPT is particularly beneficial for children experiencing anxiety, frustration, or challenges with the adaptation to new circumstances.
Play therapy allows autistic children to exercise verbal and nonverbal communication. By means of spoken language, gestures, or interactive stories, children become more at ease with self-expression.
Through play with a guide, children exercise basic social skills like turn-taking, sharing, and reading body language. These social skills enable them to develop more positive relationships with family members and peers.
Play therapy provides a secure environment where children can experiment and learn to deal with their feelings. Therapists can demonstrate skills like deep breathing or the use of a "calm-down" toy to assist children in dealing with frustration and stress.
Structured play activities encourage children to think creatively, adapt to new scenarios, and develop planning skills. This can be particularly helpful in improving their ability to adjust to changing routines or social expectations.
By providing a playful and interactive setting, play therapy makes autistic children less apprehensive about social interactions and new experiences. Gradually, this increases their confidence and readiness to interact with the world around them.
Including therapeutic play activities at home can further increase the advantages of professional play therapy. Some ideas include:
Obstacle Course: Create an indoor obstacle course with pillows, chairs, and painter's tape. Have your child jump, spin, and crawl through the various sections to promote coordination and sensory integration.
Tilt a Ball: Cut a hole at the bottom of a cardboard box to make a basic ball maze. Have your child tilt the box to direct the ball through the maze to develop hand-eye coordination.
Free the Animals: Secure plastic toy animals with painter’s tape and have your child peel them off to strengthen fine motor skills.
Clay Sculpting: Use therapy putty or clay to model different shapes or animals, enhancing dexterity and creativity.
Scavenger Hunt: Create a themed scavenger hunt to encourage problem-solving and exploration.
Ribbon Wand Dancing: Place ribbons on wooden spoons and invite dancing to music, enhancing gross motor skills and sensory awareness.
Row, Row, Row Your Boat: A cooperative game wherein children rock back and forth as they sing, enhancing cooperative play and rhythmic movement.
Parent participation is essential to the success of play therapy. By attending therapy sessions and applying learned skills in everyday life, parents can support gains and create further opportunities for development. Parents are frequently taught by therapists to use play-based strategies to facilitate communication, emotional control, and social interaction within the home environment.
When selecting a play therapist, keep the following in mind:
Credentials: Seek professionals who hold a psychology, social work, or counseling degree, and play therapy certifications (e.g., Registered Play Therapist, RPT).
Experience: Opt for a therapist experienced in treating autistic children, as they will have in-depth knowledge of ASD-specific issues.
Approach: Talk to various therapy approaches to select the one that will best suit your child's needs and personality.
To ensure maximum returns from play therapy, parents can:
Play therapy is an effective intervention for autistic children, providing a natural and fun means of establishing communication, social, and emotional skills. With the help of trained therapists and the integration of play-based strategies at home, parents can facilitate their children in acquiring key life skills in a fun and nurturing environment. Consulting professional services and remaining actively engaged in the therapy process ensures that autistic children get the assistance they require to flourish.
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