Most people are aware of type 1 and type 2 diabetes, but did you know there is a type 3 diabetes as well! It is a more obscure term. Although it is not an accepted medical diagnosis, type 3 diabetes has been discussed in the literature as a possible relationship between insulin resistance in the brain and Alzheimer's disease. This link has been described to help explain how metabolic disorders impact brain health, causing cognitive decline and dementia.

What is Type 3 Diabetes?

Type 3 diabetes is more of a misnomer because it should not be confused with type 3c diabetes, which relates to pancreatic dysfunction. The term "type 3 diabetes," on the other hand, has been loosely used by some scientists to analogously propose that Alzheimer's disease is strongly implicated with insulin resistance in the brain.

This concept was conceptualized by Dr. Suzanne de la Monte and Dr. Jack Wands of Brown University in the year 2008. This hypothesis postulated that Alzheimer's disease may be called type 3 diabetes for it bears many similarities with glucose metabolism disorder type 2 diabetes. Their concept arises from the basic principle that insulin is fundamental to blood sugar regulation, but it is also the case with the brain. When brain cells become insulin-resistant, they lose access to glucose, impairing their function.

Research published in the Journal of Diabetes Science and Technology supports this hypothesis by indicating that insulin resistance can be a significant contributor to the occurrence of dementia, also referred to as Alzheimer's. The symptoms of memory loss and diminished reasoning are associated with impaired glucose metabolism in the body, especially in the cerebral tissue.

Symptoms of Type 3 Diabetes

Although type 3 diabetes is not a "medical term," its symptoms correlate well with Alzheimer's diseases that are known to reduce the ability to think in an efficient manner and bring down brain health. These signs are:

- Loss of memory, especially short-term.

- Poor judgment and judgment ability

- Failure in recognizing people or places familiar once.

- Failure in the process of reading, writing or processing numbers

- Anxiety, agitation, or mood changes.

- Disorganized thoughts or confusion

- Lack of impulse control

As the disease advances, patients may be afflicted with severe complications including an inability to swallow or control their bodily functions. In the final stages, most patients die from fatal complications such as aspiration pneumonia.

Causes of Type 3 Diabetes

This may not be well understood with regards to type 3 diabetes, or the exact link between insulin resistance and Alzheimer's disease. Some identified contributing factors include the following:

1. Insulin Resistance

Insulin acts as an important regulatory mechanism of brain functions such as memory and cognition. The reduction in insulin signaling may impair metabolism of brain cells, thus bringing about neurodegeneration.

2. Type 2 Diabetes

These diseases show a strong relationship and those individuals diagnosed with type 2 diabetes have double chances of getting Alzheimer's. In the two, the main causes can be chronic inflammation, oxidative stress, and a defect in glucose metabolism.

3. Environmental and Lifestyle Factors

Insulin resistance associated with obesity, stress, and an unhealthy diet is considered a cause that may increase the chances of Alzheimer's disease.

Researches in Frontiers in Neuroscience and The Lancet Neurology have also highlighted that drugs used for antidiabetic medication may be crucial for the prevention or at least slowing down the course of Alzheimer's.

Treatments for Type 3 Diabetes

In 2022, in a study in Pharmaceuticals, researchers studied biomarker uptake in brain regions implicated in the faulty uptake and metabolism of blood sugar in Alzheimer’s patients.

Emerging Therapies

Research into such treatments as intranasal insulin has also been promising. Intranasal delivery of insulin directly to the brain has been reported to enhance glucose uptake by brain cells, improve memory, and boost cognitive performance. While such clinical trials have been shown to be successful, additional research is needed for safety and efficacy.

Medications

For patients being aggressive or agitated, antipsychotic drugs may be prescribed; however, therapies such as cognitive rehabilitation as well as cognitive stimulation therapy serve to preserve memory and executive function.

Lifestyle Interventions

Diet, exercise, and stress management are critical in preventing and managing insulin resistance. A review in the Journal of Alzheimer's Disease also highlighted the benefits of Kirtan Kriya meditation, which can regulate genes involved in insulin and glucose metabolism, improve sleep, and reduce inflammation.

Can Type 3 Diabetes Be Prevented?

Although type 3 diabetes is not officially recognized, its connection to Alzheimer’s disease underscores the importance of proactive measures for brain health. Some prevention strategies include:

1. Healthy Diet

Consuming a balanced diet rich in antioxidants, whole grains, and healthy fats may support brain health.

2. Regular Exercise

Physical activity improves insulin sensitivity, reduces inflammation, and enhances overall metabolic health.

3. Stress Reduction

Mindfulness practices, including meditation, have been shown to lower stress levels, which can reduce the risk of cognitive decline.

The term type 3 diabetes brings out the complex relationship between metabolic disorders and brain health. Even though it is not a recognized medical condition, the concept emphasizes the crucial role of insulin in brain function and its possible contribution to Alzheimer's disease. Continued research will hopefully provide hope for therapies such as intranasal insulin and lifestyle modifications.

It is Monday morning and your alarm rings at 6am. You hit snooze at least twice and feel why weekends are so short. A little bit rewind to two days back, Friday night after work, you did some binge watching and slept till noon on Saturday and again woke up late on Sunday. By evening, you finally felt like a human and again in a few hours, Monday came in. Your body, still confused, groggy, and also a slightly resentful. You feel like you are jetlagged even though you have not even boarded a flight.

This is not laziness or poor discipline, this is social jetlag. Many Indians are living through it. Many of us have two sleep times. One for weekdays and one for the weekends and if you are on a roaster, then your sleeping time adjusts according to your off-days. But the truth is you are not sleeping enough at least for the five days you work and make up for it on your off days. This is what scientists call a social jet lag and it is raising long-term health risks.

What Exactly Is Social Jetlag?

A 2012 study by Till Roenneberg explains that the term 'social jetlag' refers to the mismatch between your biological clock and your social clock. Your biological clock is governed by circadian rhythms, internal processes that decide when you feel sleepy or alert. Your social clock is set by work timings, school schedules, household responsibilities, and social expectations.

Most people sleep earlier and wake up earlier on weekdays because they have to. On weekends, they sleep later and wake up later to recover lost sleep. Researchers describe this as similar to flying across time zones and back every week, except your environment does not change. The sun rises at the same time, but your sleep does not.

Studies suggest that nearly 80 percent of people experience some degree of irregular sleep by shifting sleep times between weekdays and weekends. This pattern has become common due to artificial lighting, late-night screen exposure, and work schedules that are misaligned with natural circadian preferences.

Modern Life Makes It Worse, Here's Why

Artificial light has quietly changed how humans interact with night and day. Evening exposure to bright lights from phones, televisions, and laptops delays the body’s internal clock. This makes it harder to fall asleep early, even when you need to wake up early the next morning.

Over time, this weakens the natural cues that tell the body when it is time to rest and when it is time to be active. Researchers note that this effect creates more late chronotypes, people who naturally feel alert later at night. Unfortunately, most school and office schedules still reward early risers.

The result is a repeated pattern of sleep restriction during weekdays and catch-up sleep on weekends. Unlike travel jetlag, which resolves once the body adjusts to a new light-dark cycle, social jetlag does not correct itself. The solar cycle stays the same, while sleep timing keeps shifting back and forth.

Light is the primary driver of circadian rhythm. In the morning, exposure to sunlight tells the brain to stop producing melatonin, the hormone that makes us sleepy so we feel alert and ready for the day. By evening, melatonin production rises, pushing us toward rest. Night shifts turn this cycle upside down. Instead of winding down, the body is forced to stay active at the very hours it is wired for repair and recovery.

This constant mismatch creates what scientists call 'social jetlag. Your body never gets used to it, because it runs on an internal clock and this is why despite working the same shifts for years, you feel confused.

Indians Are Sleeping Way Less

Data from India paints a worrying picture. A nationwide LocalCircles survey found that 55 percent of Indians get less than six hours of uninterrupted sleep each night. This is an increase from 50 percent the year before, showing that sleep deprivation is getting worse, not better.

Among the reasons cited were late bedtimes combined with early household responsibilities, frequent nighttime awakenings, environmental noise, mosquitoes, and medical conditions like sleep apnea. Even those who spend enough time in bed often experience fragmented sleep.

Wearable sleep data tells a similar story. Fitbit’s global sleep analysis placed Indians as the second most sleep-deprived population after Japan. On average, Indians sleep just over seven hours a night, nearly 50 minutes less than users in the UK and significantly less than Americans. Indians also get the lowest amount of REM sleep globally, a stage critical for memory, emotional regulation, and mental health.

Social jetlag is especially pronounced among adolescents and young adults. Research consistently shows that teenagers naturally shift toward later sleep and wake times due to developmental changes. However, early school start times force them to wake up before their biological clocks are ready.

Late chronotypes accumulate sleep debt during the week and try to repay it on weekends. This pattern has been linked to higher body mass index, metabolic issues, daytime sleepiness, and poorer academic performance. Living against the clock, researchers suggest, may be quietly contributing to the rising burden of obesity and mental health concerns.

In India, academic pressure, coaching classes, screen use, and reduced parental control over sleep schedules only amplify this misalignment.

Social Jet Lag Is Not Just About Feeling Tired, It Has Grave Health Impact

Hormones take the first hit. Our body gets confused on how to regulate melatonin, which is a sleep hormone and cortisol, which is the wake up hormone. It also reduces appetite suppressing hormone leptin, while turning up the hunger hormone ghrelin. This is why you feel the midnight munchies. Chronic sleep deprivation could also lead to prediabetics, as increasing sugar cravings make it difficult for people to prioritize healthy eating.

Studies have associated it with increased risks of obesity, metabolic syndrome, and mental health disorders. It has also been linked to lower productivity, reduced concentration, and mood disturbances.

Addressing social jetlag requires more than sleep tips. Experts suggest later school start times, flexible work hours, reduced evening light exposure, and greater awareness of circadian health. Small changes, like maintaining similar sleep timings on weekdays and weekends, can help, but they cannot fully solve a systemic problem.

Until then, millions of Indians will continue waking up exhausted, wondering why rest feels so elusive.

Delhi's air quality index (AQI) remained in the 'very poor' category on Wednesday, as the city's average AQI stood at 329 as of 7am. The Central Pollution Control Board (CPCB) data in all stations, though, showed that it was below the 'severe' range, with some locations in the 'poor' range too.

Delhi has not yet experienced the cold wave this season, however, the city is still covered with smog, and the air quality continues to threaten people's health. The Delhi winters haven't peaked yet, so what made the pollution so worse already? Gufran Beig, Chair Professor at National Institute of Advanced Studies, IISC-Campus and Founder Project Director SAFAR, writes for Indian Express that while the AQI right now may be 'very poor', "It will return, playing hide-and-seek for at least another month".

No Buffer To Protect Public Health From Delhi's Air Pollution

He says that the wind speed across Delhi and its wider airshed "dropped close to zero". This means "nothing was coming in and nothing was going out". He also noted that stubble burning in the neighboring state is not the problem, rather Delhi is choking on its own emission. He explains that the vertical dispersion was restricted by a shallow inversion layer, which was approximately 500 to 700 metres deep. Which means, emission from a fixed point sources linger where they released, and it creates a localized pollution hotspot instead of spreading, because there was almost no wind.

He explained that the atmosphere here has temporarily lost its capacity to clean itself. Even if this is for couple of days, this has become very apparent in Delhi. "When the air stands still, stagnation sets in, ventilation collapses, and the system is left with no buffer to protect public health. When the weather naps, there is nowhere left to hide. Yet, we continue to blame the weather instead of our emissions," he writes.

Read: AQI Explained: It’s Not Temperature, As Delhi CM Says, Here’s What the Air Quality Index Really Means

Could There Be A Solution?

Beig writes that if Delhi is able to cut its local pollution by 50 per cent, the pollution too could drop by 50 per cent. The emission should happen across the airshed. However, the focus should be for a long-term action on the source of emission and not short-term optics like cloud seeding, smog towers, water sprinkling or air purifiers.

In fact, as per a study published in Sustainability (MDPI), an open access journal, which mapped Delhi's air quality between 1990 to 2022 and found that transports emit around 10 to 30% of pollution, whereas agricultural residue burning, which is a seasonal source of pollution leads to less than 3% of pollution, whereas firecrackers, another seasonal source, leads to less than 1% of pollution.

Pollution's Impact On Health

However, despite the global studies highlighting the country's ever-growing pollution problem, the Centre stated that "there is no conclusive data available in the country to establish direct correlation if death/disease exclusively due to air pollution."

The study estimated: “1·5 million deaths occurred annually due to long-term exposure to PM2·5 in India every year in excess of the 5 μg/m3 that is recommended by the WHO ambient air quality guidelines.”

The study noted that every 10μg/m³ increase in annual PM2·5 concentration was associated with an 8.6 pc higher risk of all-cause mortality.

Using India’s National Ambient Air Quality Standards, researchers estimate that about 3.8 million deaths between 2009 and 2019 were linked to PM2.5 exposure. When WHO guidelines were applied, the number rose sharply to 16.6 million, nearly one-fourth of all deaths in the country. The analysis relied on advanced causal methods and high-resolution models that mapped district-level PM2.5 exposure across India, while accounting for factors such as socioeconomic status, age distribution, and indoor air pollution.

Norovirus, often called the “stomach flu” or “winter vomiting illness,” is currently circulating in California and across the United States. Health experts say proper cleaning and disinfecting can slow its spread. These precautions matter because norovirus is extremely contagious and there is no specific treatment for it, according to the Centers for Disease Control and Prevention.

Between August 1 and November 13, health officials recorded 153 norovirus outbreaks across 14 states. The CDC defines an outbreak as two or more similar illnesses linked to suspected or lab-confirmed norovirus cases. Although California is not among the states reporting outbreaks, CDC data shows a noticeable rise in positive norovirus tests throughout November across the western US.

What Is Norovirus?

Norovirus is described as a “highly contagious” virus that causes vomiting, diarrhea, and stomach cramps, according to the California Department of Public Health. It leads to acute gastroenteritis, which means inflammation of the stomach or intestines, and affects people of all ages, the CDC said.

Despite its nickname, norovirus has nothing to do with influenza. The flu is caused by the influenza virus, not norovirus, the agency clarified.

Winter Vomiting Disease: How Does The Stomach Bug Spread?

Norovirus spreads easily from person to person, especially while someone is actively sick, according to the California Department of Public Health. Symptoms usually last one to three days, but a person can still spread the virus for up to two days after they start feeling better.

The virus is present in vomit and stool and can spray into the air or settle on nearby surfaces. It can survive for weeks on uncleaned items such as countertops, phones, and doorknobs, the department said.

“You can get sick after touching or caring for someone who is sick, or after touching or eating something that is contaminated,” the department noted.

Norovirus spreads quickly in crowded or enclosed settings, including schools, child care facilities, hospitals, nursing homes, jails, and cruise ships.

According to state and federal health officials, the most common ways people catch norovirus include:

• Touching, caring for, or sharing food with someone who has norovirus
• Eating or drinking contaminated food or beverages, including undercooked shellfish like oysters
• Touching a contaminated surface and then touching your mouth before washing your hands
• Sharing a toilet or bathroom with someone who is sick
• Swallowing contaminated water, including water from swimming pools or recreational areas
• Cleaning up vomit or diarrhea without protective gear, such as gloves or a face mask

Do You Need To Disinfect After Norovirus?

“If you or someone in your household has norovirus, it’s important to clean and disinfect areas where vomiting or diarrhea occurred,” the California Department of Public Health advised. Cleaning with soap and water removes germs, while disinfecting kills those that remain.

You can use commercial disinfectants, but it’s important to read the label and make sure norovirus is listed among the germs it targets. You can also check the Environmental Protection Agency’s registration number and confirm it appears on the EPA’s List G, which includes products proven effective against norovirus.

Another option is making a bleach solution at home. The US Department of Agriculture recommends mixing 5 to 25 tablespoons of household bleach with one gallon of water. This solution should be used only on hard or nonporous surfaces and applied with a spray bottle or disposable mop, sponge, or paper towel. Let it sit for about five minutes before wiping it away.

The USDA also advises paying close attention to frequently touched items such as doorknobs, handles, and remote controls. Many disinfectant wipes do not fully kill norovirus, the agency warned.

How To Disinfect After Norovirus?

The CDC recommends wearing rubber or disposable gloves while cleaning. Use paper towels to wipe the affected area completely, then place the towels in a plastic trash bag. The California Department of Public Health also suggests wearing a face mask.

After disinfecting, clean the area again with soap and water, the CDC said. Keep in mind that vomit can aerosolize the virus, meaning surfaces several feet away may also be contaminated, according to the USDA.

Once you’re done, throw away the gloves and mask, then take out the trash, the California Department of Public Health advised.