Most people are aware of type 1 and type 2 diabetes, but did you know there is a type 3 diabetes as well! It is a more obscure term. Although it is not an accepted medical diagnosis, type 3 diabetes has been discussed in the literature as a possible relationship between insulin resistance in the brain and Alzheimer's disease. This link has been described to help explain how metabolic disorders impact brain health, causing cognitive decline and dementia.

What is Type 3 Diabetes?

Type 3 diabetes is more of a misnomer because it should not be confused with type 3c diabetes, which relates to pancreatic dysfunction. The term "type 3 diabetes," on the other hand, has been loosely used by some scientists to analogously propose that Alzheimer's disease is strongly implicated with insulin resistance in the brain.

This concept was conceptualized by Dr. Suzanne de la Monte and Dr. Jack Wands of Brown University in the year 2008. This hypothesis postulated that Alzheimer's disease may be called type 3 diabetes for it bears many similarities with glucose metabolism disorder type 2 diabetes. Their concept arises from the basic principle that insulin is fundamental to blood sugar regulation, but it is also the case with the brain. When brain cells become insulin-resistant, they lose access to glucose, impairing their function.

Research published in the Journal of Diabetes Science and Technology supports this hypothesis by indicating that insulin resistance can be a significant contributor to the occurrence of dementia, also referred to as Alzheimer's. The symptoms of memory loss and diminished reasoning are associated with impaired glucose metabolism in the body, especially in the cerebral tissue.

Symptoms of Type 3 Diabetes

Although type 3 diabetes is not a "medical term," its symptoms correlate well with Alzheimer's diseases that are known to reduce the ability to think in an efficient manner and bring down brain health. These signs are:

- Loss of memory, especially short-term.

- Poor judgment and judgment ability

- Failure in recognizing people or places familiar once.

- Failure in the process of reading, writing or processing numbers

- Anxiety, agitation, or mood changes.

- Disorganized thoughts or confusion

- Lack of impulse control

As the disease advances, patients may be afflicted with severe complications including an inability to swallow or control their bodily functions. In the final stages, most patients die from fatal complications such as aspiration pneumonia.

Causes of Type 3 Diabetes

This may not be well understood with regards to type 3 diabetes, or the exact link between insulin resistance and Alzheimer's disease. Some identified contributing factors include the following:

1. Insulin Resistance

Insulin acts as an important regulatory mechanism of brain functions such as memory and cognition. The reduction in insulin signaling may impair metabolism of brain cells, thus bringing about neurodegeneration.

2. Type 2 Diabetes

These diseases show a strong relationship and those individuals diagnosed with type 2 diabetes have double chances of getting Alzheimer's. In the two, the main causes can be chronic inflammation, oxidative stress, and a defect in glucose metabolism.

3. Environmental and Lifestyle Factors

Insulin resistance associated with obesity, stress, and an unhealthy diet is considered a cause that may increase the chances of Alzheimer's disease.

Researches in Frontiers in Neuroscience and The Lancet Neurology have also highlighted that drugs used for antidiabetic medication may be crucial for the prevention or at least slowing down the course of Alzheimer's.

Treatments for Type 3 Diabetes

In 2022, in a study in Pharmaceuticals, researchers studied biomarker uptake in brain regions implicated in the faulty uptake and metabolism of blood sugar in Alzheimer’s patients.

Emerging Therapies

Research into such treatments as intranasal insulin has also been promising. Intranasal delivery of insulin directly to the brain has been reported to enhance glucose uptake by brain cells, improve memory, and boost cognitive performance. While such clinical trials have been shown to be successful, additional research is needed for safety and efficacy.

Medications

For patients being aggressive or agitated, antipsychotic drugs may be prescribed; however, therapies such as cognitive rehabilitation as well as cognitive stimulation therapy serve to preserve memory and executive function.

Lifestyle Interventions

Diet, exercise, and stress management are critical in preventing and managing insulin resistance. A review in the Journal of Alzheimer's Disease also highlighted the benefits of Kirtan Kriya meditation, which can regulate genes involved in insulin and glucose metabolism, improve sleep, and reduce inflammation.

Can Type 3 Diabetes Be Prevented?

Although type 3 diabetes is not officially recognized, its connection to Alzheimer’s disease underscores the importance of proactive measures for brain health. Some prevention strategies include:

1. Healthy Diet

Consuming a balanced diet rich in antioxidants, whole grains, and healthy fats may support brain health.

2. Regular Exercise

Physical activity improves insulin sensitivity, reduces inflammation, and enhances overall metabolic health.

3. Stress Reduction

Mindfulness practices, including meditation, have been shown to lower stress levels, which can reduce the risk of cognitive decline.

The term type 3 diabetes brings out the complex relationship between metabolic disorders and brain health. Even though it is not a recognized medical condition, the concept emphasizes the crucial role of insulin in brain function and its possible contribution to Alzheimer's disease. Continued research will hopefully provide hope for therapies such as intranasal insulin and lifestyle modifications.

Tobacco use remains a global epidemic and one of the leading preventable causes of death worldwide. Despite a strong desire among many users to quit, relapse rates remain alarmingly high. A new study by researchers at the All India Institute of Medical Sciences (AIIMS), New Delhi, suggests that yoga could be a valuable tool in helping people quit tobacco.

Yoga Shows Promise for Tobacco Cessation

To evaluate the effectiveness of yoga in tobacco cessation, researchers led by Dr Gautam Sharma, Department of Cardiology and Centre for Integrative Medicine and Research, AIIMS, conducted a meta-analysis of five randomized controlled trials (RCTs) published up to September 2024.

The review included adults aged 18 years and older who used any form of tobacco, excluding vaping products. Participants were randomly assigned to yoga either as a standalone intervention or alongside conventional cessation treatments.

The primary outcome assessed was the 7-day point prevalence abstinence (7PPA), a standard measure of smoking cessation. Secondary outcomes included quality of life, depression, anxiety, and mood states.

The findings suggest that “yoga may serve as a moderately effective intervention for tobacco cessation, with an estimated effectiveness of around 50 per cent”, the team said in the paper.

Also read: Yoga May Boost Fertility And Hormonal Health In Women With PCOS

How Yoga May Help People Quit Tobacco

Researchers found that active yoga styles such as Hatha, Vinyasa, and Iyengar yoga improved abstinence rates by helping reduce stress, depression, and negative emotions often associated with tobacco withdrawal.

Pranayama, or yogic breathing exercises, was found to reduce cravings and negative affect, making it easier for participants to cope with withdrawal symptoms.

The review also highlighted the importance of addressing psychological factors linked to tobacco addiction, including perceived stress, anxiety, depression, and emotional distress—all of which are known contributors to relapse.

While some studies reported stronger psychological benefits than others, overall evidence suggests yoga may support emotional well-being during the quitting process.

Yoga and Tobacco Addiction

Also read: Yoga Shows Promise for Anxiety Relief And Seizure Control In Epilepsy, Claims Study

Researchers believe yoga may help manage tobacco addiction through several biological mechanisms.

Nicotine stimulates nicotinic cholinergic receptors in the brain, triggering the release of neurotransmitters that produce pleasurable and rewarding effects. During withdrawal, stress-related hormones increase, leading to anxiety, cravings, and emotional discomfort.

Yoga appears to counter these effects by shifting the body from a state of sympathetic nervous system dominance ("fight or flight") to parasympathetic dominance ("rest and digest").

Read More: India Launches New Yoga Protocols To Fight Diabetes, High BP, Asthma

This shift may reduce activity in the hypothalamic-pituitary-adrenal (HPA) axis, lower cortisol levels, and decrease stress hormone production, helping individuals better manage cravings and withdrawal symptoms.

The team also noted that controlled breathing techniques can significantly influence emotional regulation, with voluntary breath control accounting for substantial variations in emotional states such as anger, fear, and joy.

India alone has more than 270 million active tobacco users. Given the widespread use of smokeless tobacco in the region—and the limited effectiveness of standard cessation medications for these users—yoga could offer an accessible, culturally familiar, and low-cost complementary approach, the researchers stressed.

While the results are encouraging, researchers also cautioned that larger and more standardized studies are needed.

Every day, hospitals care for patients whose survival depends on a simple yet irreplaceable resource—donated blood. A mother experiencing severe bleeding after childbirth, a child with thalassemia requiring regular transfusions, a cancer patient undergoing chemotherapy, or a victim of a road traffic accident may all rely on timely access to safe blood.

Despite medical advances, blood remains unique. It cannot be manufactured or artificially replicated. It can only come from healthy individuals who choose to donate. This makes blood donation one of the most vital contributions a person can make to healthcare and society.

It is important to understand that the impact of a single donation extends far beyond what most people imagine.

One Donation, Multiple Patients

When a person donates whole blood, it is separated into components—red blood cells, platelets, and plasma. Each component serves a different purpose. Red blood cells carry oxygen and are essential in treating anemia and blood loss. Platelets help control bleeding and are critical for patients undergoing chemotherapy. Plasma contains proteins and clotting factors required for managing bleeding disorders.

Because these components can be used independently, a single donation has the potential to benefit multiple patients with different medical conditions. One act of donation can therefore support several lives.

Why Blood Supply Must Be Continuous

A common misconception is that blood is needed only during emergencies or disasters. In reality, the demand for blood is constant. Patients with chronic conditions such as thalassemia require regular transfusions throughout their lives. Cancer treatments, major surgeries, organ transplants, complicated pregnancies, and trauma care all depend on a steady and reliable blood supply.

Unlike many medical resources, blood components have limited shelf lives. Platelets can only be stored for a few days, and red blood cells have a defined storage period. This means blood stocks must be continuously replenished. A stable blood supply cannot be created overnight—it depends on regular and voluntary donations throughout the year.

The Importance Of Voluntary Donors

The safest and most reliable blood supply comes from voluntary donors who give blood without expectation of reward. However, maintaining this supply is an ongoing challenge. It requires not only recruiting new donors but also encouraging previous donors to return.

Many individuals who donate once do not return, often due to lack of awareness, time constraints, or fading motivation. Yet every regular donor begins as a first-time donor. A positive first donation experience plays a key role in building long-term commitment.

Hospitals, workplaces, and community organizations play a crucial role in promoting donation through awareness campaigns, outreach programs, and well-organized blood donation drives. Sustained engagement is essential to ensure that donors remain connected to this life-saving cause.

What Motivates People To Donate

Blood donation is not just a medical act—it is a powerful expression of social responsibility. Most donors never meet the individuals they help, yet they donate willingly to support someone in need. This anonymous act of giving reflects compassion, empathy, and a shared sense of humanity.

People are motivated to donate for many reasons. Some are driven by altruism and the desire to help others. Others are influenced by personal experiences, community values, or encouragement from family and peers. Awareness campaigns and social engagement can also play a significant role in shaping attitudes towards donation.

Understanding these motivations is important because it helps design more effective strategies to encourage both first-time and repeat donors.

Addressing Common Concerns

Despite its importance, many eligible individuals hesitate to donate due to fear or uncertainty. Concerns about pain, weakness, or safety are common. However, blood donation is a carefully regulated process conducted by trained healthcare professionals.

Donors undergo screening to ensure that the procedure is safe for both themselves and the recipient. The donation itself takes only a short time, and most people can resume normal activities soon afterward. Efforts to improve donor comfort and reduce anxiety have further enhanced the overall donation experience.

For many first-time donors, the greatest takeaway is a sense of satisfaction and pride in having contributed to saving lives.

Every First-Time Donor Matters

One of the greatest challenges in maintaining a stable blood supply is ensuring a continuous flow of new donors. As regular donors age or become ineligible, new volunteers are needed to sustain the system.

Encouraging first-time donors is therefore critical. With the right experience and awareness, a first-time donor can become a lifelong contributor, potentially helping dozens of patients over the years. Simple follow-up communication and continued engagement can significantly improve donor retention.

Families, educational institutions, workplaces, and healthcare providers all have a role to play in encouraging individuals to take this first step.

A Gift That Saves and Sustains Lives

Blood is more than a medical resource—it is a gift that cannot be bought, manufactured, or stored indefinitely. It represents hope, survival, and the generosity of one human being towards another.

Behind every successful surgery, every recovering patient, and every saved life, there is often an unseen donor whose contribution made that outcome possible.

A single donation may take only a few minutes, but its impact extends far beyond a single individual. It supports families, strengthens healthcare systems, and builds a culture of care and compassion within communities.

The message is simple: if you are eligible, consider donating. Your one unit of blood may help many—and could make the difference between life and loss for someone in need.

Extremes of heatwaves and ozone pollution are intensifying, increasing heart- and lung disease-related deaths in India, according to a new study.

Heatwaves are associated with heat stress, dehydration, heat exhaustion, heatstroke, and cardiovascular strain, while ground-level ozone is a harmful air pollutant linked to heart and lung diseases and increased mortality.

Researchers from the Indian Institute of Technology (IIT), Kharagpur, found that surface ozone levels reach 85–110 micrograms per cubic meter (μg/m³) in northern India during heatwaves—far exceeding the World Health Organization (WHO) guideline of 70 μg/m³.

The study found that heatwaves significantly intensify exposure to toxic ground-level ozone, a harmful air pollutant linked to heart and lung diseases and increased mortality.

“In 2024 alone, ozone exposure during heatwaves was associated with 15,615 deaths from ischemic heart disease and another 10,898 deaths from chronic obstructive pulmonary disease (COPD),” said researchers Parambat Sangeetha of Kerala University of Fisheries and Ocean Studies and Jayanarayanan Kuttippurath of IIT Kharagpur in the paper.

Overall, ozone exposure during heatwave conditions was associated with more than 26,500 deaths in 2024, according to the study published in npj Clean Air. Before heatwave conditions, ozone exposure was linked to 490 deaths from ischemic heart disease and 342 deaths from COPD.

Why Ozone Levels Rise During Heatwaves

Surface ozone is not released directly into the atmosphere. Instead, it forms when sunlight triggers chemical reactions among existing pollutants—a process that accelerates during periods of extreme heat.

“Ozone is very harmful, while NO₂ (nitrogen dioxide) and HCHO (formaldehyde) directly damage the respiratory system,” the authors said.

How the Study Was Conducted

For the study, researchers combined two decades of temperature records from the India Meteorological Department (IMD) with satellite observations and global weather datasets to track ozone levels and the gases responsible for its formation.

Heatwaves between 2004 and 2024 were identified using standard temperature thresholds. The team identified 188 heatwave events over the two-decade period, with the most severe years—2010, 2016, 2019, and 2024—occurring after strong El Niño episodes.

The Western Himalayas recorded the sharpest long-term increase in ozone levels, exceeding WHO guidelines by 115 percent in 2024.

The researchers concluded that “coupled heat–ozone extremes are intensifying, requiring urgent integrated climate–air quality policy action.”

Regions Most Affected

Severe heatwave conditions predominantly affect:

• Jammu
• Rajasthan
• Gujarat
• Madhya Pradesh
• Punjab
• Haryana
• Chandigarh
• Uttar Pradesh
• Delhi
• Himachal Pradesh
• Vidarbha
• Maharashtra

The heatwave belt often expands further into:

• Uttarakhand
• Odisha
• Chhattisgarh
• Bihar

Impact on Lung and Heart Health

The study noted that chronic obstructive pulmonary disease (COPD) is highly sensitive to changes in temperature, humidity, and air quality.

Dr. Amit Kumar Mandal, Senior Director of Pulmonology at Paras Health, explained that extreme heat combined with pollution places significant stress on multiple organs.

“People often think heatwaves only affect the skin or cause dehydration, but when extreme heat combines with high pollution levels, the body starts functioning as if it is constantly under attack,” he told HealthandMe.

“The lungs are forced to work harder to filter hot, polluted air, while the heart simultaneously struggles to regulate body temperature. This invisible overload can quietly trigger inflammation, breathing distress, sudden BP fluctuations, and cardiac strain, even in people who otherwise consider themselves healthy.”

Warning Signs to Watch For

The expert noted that early symptoms are often subtle and may go unnoticed. Common symptoms seen during heatwave and pollution episodes include:

• Persistent tiredness
• Irritability
• Disturbed sleep
• Headaches
• Chest heaviness
• Unusual breathlessness

How to Reduce Health Risks

Recommended precautions include:

• Staying hydrated
• Avoiding direct sunlight during peak afternoon hours
• Wearing light cotton clothing
• Using masks in polluted areas
• Maintaining proper indoor ventilation.