Most people are aware of type 1 and type 2 diabetes, but did you know there is a type 3 diabetes as well! It is a more obscure term. Although it is not an accepted medical diagnosis, type 3 diabetes has been discussed in the literature as a possible relationship between insulin resistance in the brain and Alzheimer's disease. This link has been described to help explain how metabolic disorders impact brain health, causing cognitive decline and dementia.

What is Type 3 Diabetes?

Type 3 diabetes is more of a misnomer because it should not be confused with type 3c diabetes, which relates to pancreatic dysfunction. The term "type 3 diabetes," on the other hand, has been loosely used by some scientists to analogously propose that Alzheimer's disease is strongly implicated with insulin resistance in the brain.

This concept was conceptualized by Dr. Suzanne de la Monte and Dr. Jack Wands of Brown University in the year 2008. This hypothesis postulated that Alzheimer's disease may be called type 3 diabetes for it bears many similarities with glucose metabolism disorder type 2 diabetes. Their concept arises from the basic principle that insulin is fundamental to blood sugar regulation, but it is also the case with the brain. When brain cells become insulin-resistant, they lose access to glucose, impairing their function.

Research published in the Journal of Diabetes Science and Technology supports this hypothesis by indicating that insulin resistance can be a significant contributor to the occurrence of dementia, also referred to as Alzheimer's. The symptoms of memory loss and diminished reasoning are associated with impaired glucose metabolism in the body, especially in the cerebral tissue.

Symptoms of Type 3 Diabetes

Although type 3 diabetes is not a "medical term," its symptoms correlate well with Alzheimer's diseases that are known to reduce the ability to think in an efficient manner and bring down brain health. These signs are:

- Loss of memory, especially short-term.

- Poor judgment and judgment ability

- Failure in recognizing people or places familiar once.

- Failure in the process of reading, writing or processing numbers

- Anxiety, agitation, or mood changes.

- Disorganized thoughts or confusion

- Lack of impulse control

As the disease advances, patients may be afflicted with severe complications including an inability to swallow or control their bodily functions. In the final stages, most patients die from fatal complications such as aspiration pneumonia.

Causes of Type 3 Diabetes

This may not be well understood with regards to type 3 diabetes, or the exact link between insulin resistance and Alzheimer's disease. Some identified contributing factors include the following:

1. Insulin Resistance

Insulin acts as an important regulatory mechanism of brain functions such as memory and cognition. The reduction in insulin signaling may impair metabolism of brain cells, thus bringing about neurodegeneration.

2. Type 2 Diabetes

These diseases show a strong relationship and those individuals diagnosed with type 2 diabetes have double chances of getting Alzheimer's. In the two, the main causes can be chronic inflammation, oxidative stress, and a defect in glucose metabolism.

3. Environmental and Lifestyle Factors

Insulin resistance associated with obesity, stress, and an unhealthy diet is considered a cause that may increase the chances of Alzheimer's disease.

Researches in Frontiers in Neuroscience and The Lancet Neurology have also highlighted that drugs used for antidiabetic medication may be crucial for the prevention or at least slowing down the course of Alzheimer's.

Treatments for Type 3 Diabetes

In 2022, in a study in Pharmaceuticals, researchers studied biomarker uptake in brain regions implicated in the faulty uptake and metabolism of blood sugar in Alzheimer’s patients.

Emerging Therapies

Research into such treatments as intranasal insulin has also been promising. Intranasal delivery of insulin directly to the brain has been reported to enhance glucose uptake by brain cells, improve memory, and boost cognitive performance. While such clinical trials have been shown to be successful, additional research is needed for safety and efficacy.

Medications

For patients being aggressive or agitated, antipsychotic drugs may be prescribed; however, therapies such as cognitive rehabilitation as well as cognitive stimulation therapy serve to preserve memory and executive function.

Lifestyle Interventions

Diet, exercise, and stress management are critical in preventing and managing insulin resistance. A review in the Journal of Alzheimer's Disease also highlighted the benefits of Kirtan Kriya meditation, which can regulate genes involved in insulin and glucose metabolism, improve sleep, and reduce inflammation.

Can Type 3 Diabetes Be Prevented?

Although type 3 diabetes is not officially recognized, its connection to Alzheimer’s disease underscores the importance of proactive measures for brain health. Some prevention strategies include:

1. Healthy Diet

Consuming a balanced diet rich in antioxidants, whole grains, and healthy fats may support brain health.

2. Regular Exercise

Physical activity improves insulin sensitivity, reduces inflammation, and enhances overall metabolic health.

3. Stress Reduction

Mindfulness practices, including meditation, have been shown to lower stress levels, which can reduce the risk of cognitive decline.

The term type 3 diabetes brings out the complex relationship between metabolic disorders and brain health. Even though it is not a recognized medical condition, the concept emphasizes the crucial role of insulin in brain function and its possible contribution to Alzheimer's disease. Continued research will hopefully provide hope for therapies such as intranasal insulin and lifestyle modifications.

Summer can be difficult for the eyes, often in ways people do not immediately notice. Most of the attention during this season goes to drinking enough water, avoiding heat, and protecting the skin. Eye care usually comes much later, often only after discomfort begins. Long hours in the sun, dry surroundings, heat, and outdoor exposure can all leave the eyes feeling uneasy, especially over repeated days.

“During the summer season, we commonly see an increase in patients presenting with ocular surface discomfort, including dryness, itching, redness, burning sensation, and watering. Prolonged exposure to heat, ultraviolet radiation, dust, and air-conditioned environments can disturb the normal tear film and aggravate underlying allergic or dry eye conditions. In some cases, repeated eye rubbing and poor hygiene may also increase the risk of secondary irritation or infection. Timely preventive care and early attention to persistent symptoms are important to avoid worsening of these seasonal eye concerns,” says Dr Niteen Dedhia, Medical Director, Ojas Maxivision Super Specialty Eye Hospitals.

When heat and dehydration begin to show in your eyes

A common experience during summer is that the eyes simply do not feel as comfortable as they usually do. There may be a slight burning sensation, or the eyes may feel tired much earlier in the day, especially after being outdoors or spending hours in cooled indoor spaces. With the body losing fluids more quickly in hot weather, the eyes can also feel the effects. Many people do not immediately connect this discomfort to dehydration, but it plays a bigger role than expected. Added screen time indoors only makes this more noticeable.

Dust, sweat, and allergies adding to irritation

During summer, the eyes are exposed to many small everyday irritants. Dust on the roads, dry wind, pollution, and even sweat can all add to the discomfort. In some people, this shows up as itching, mild redness, or watering that keeps returning. Rubbing the eyes may feel like the easiest response, but it often makes the irritation worse. If this continues for days, even a minor problem can start feeling quite troublesome.

Sunlight and its hidden impact on eye comfort

Spending time in strong sunlight can be more exhausting for the eyes than most people realise. It is not just the brightness — by the end of the day, the eyes may feel heavy, watery, or unusually sensitive to light. Many people wear sunglasses, but not every pair is suitable for eye protection. Dark lenses may reduce glare, but that does not always mean they are blocking harmful rays. This is one reason discomfort can continue even when someone feels they have protected their eyes properly.

Small habits that make a noticeable difference

Managing summer eye discomfort does not require anything complicated. Staying well hydrated throughout the day helps more than most people expect. Using good-quality sunglasses, limiting time in the harsh afternoon sun, and simply rinsing the eyes after coming back from outside can ease a lot of irritation. Clean habits also matter in day-to-day care. Using your own towel, avoiding frequent hand contact with the eyes, and stepping away from screens occasionally can all help reduce strain and irritation.

Most people treat heartburn the way they treat a bad day: they reach for an antacid and move on. But for some patients, that familiar burning sensation is not just a digestive nuisance. It can be an early sign of something far more serious. A type of cancer called gastroesophageal junction (GEJ) adenocarcinoma develops quietly at the point where the food pipe meets the stomach, and it is frequently mistaken for routine acidity—until it is not.

Dr Ankit Jain, Senior Consultant, Medical Oncology, at Indraprastha Apollo Hospitals, in an interaction with Health and Me, spoke about the difference between cancer and heartburn symptoms.

What Is the Gastroesophageal Junction, and Why Does It Matter?

The gastroesophageal junction is simply the meeting point between the oesophagus and the stomach. When stomach acid repeatedly irritates this area over months or years, the lining can begin to change at a cellular level. This change, known as Barrett’s oesophagus, is a precancerous condition that often develops silently in people with chronic acid reflux. If left undetected, it can progress to GEJ adenocarcinoma. The tricky part is that this cancer does not behave exactly like oesophageal cancer or stomach cancer. It sits between the two, and that makes both diagnosis and treatment more nuanced.

Signs That Go Beyond Ordinary Heartburn

Heartburn is common across India, yet certain symptoms should not be brushed aside as routine acidity. If any of the following are present, a doctor’s visit should not be delayed:

1. Difficulty swallowing that starts with solid foods and gradually worsens
2. Unintended weight loss with no clear explanation
3. Chest or upper abdominal pain that does not improve with antacids
4. Unusual fatigue or anaemia, especially without another known cause
5. Blood in vomit or black, tarry stools

These are not panic triggers; they are signals worth investigating promptly.

The Case for Timely Screening

For patients over 40 with long-standing reflux, obesity, a smoking history, or a family history of upper digestive cancers, a baseline endoscopy is a reasonable and potentially life-saving step. GEJ adenocarcinoma caught early is far more treatable than the same cancer found at an advanced stage. The window for early detection exists, but it requires action before symptoms become severe. Persistent reflux deserves more than a repeat prescription. Sometimes, it deserves a closer look.

India is taking significant steps to enhance its vaccination strategy, with a special focus on adults, particularly those aged 55 and above, said Dr. N K Arora, Member of the National Technical Advisory Group on Immunisation in India (NTAGI), as part of the World Immunization Week.

NTAGI is the highest advisory body on immunization in the country, which consists of independent experts who provide recommendations on vaccines after reviewing data on disease burden, efficacy, and cost-effectiveness of vaccines.

In an exclusive interaction with HealthandMe, Dr. Arora shared that the country “is in the process of establishing priority pathogens and vaccines aimed at the adult population”.

This initiative will target those above the age of 55 or 60 to tackle infections that are particularly serious in older individuals, especially those living with chronic conditions like diabetes, hypertension, and cancer.

“The process has started. This year, we will be moving in that direction,” said Dr. Arora.

HPV Vaccination: A Milestone in Preventing Cervical Cancer

The expert lauded the introduction of the HPV vaccine for young girls. Dr. Arora highlighted the critical importance of this initiative, given India’s status as the country with the highest number of cervical cancer cases globally.

"Cervical cancer is preventable by the HPV vaccine, and we are now in the fortunate position of having a domestically manufactured vaccine," he explained.

The first round of vaccinations has already commenced, and Dr. Arora urged the media and public to dispel any misinformation surrounding the vaccine to ensure its success.

An Indigenous Dengue Vaccine

Further, the vaccine expert highlighted the potential introduction of an indigenous dengue vaccine, currently undergoing trials.

“The trials will take at least two and a half years, which means by the end of 28, we will have the results,” Dr. Arora said.

He emphasized the severity of dengue when it turns from a mild illness into a severe one, particularly among young adults.

The dengue vaccine, being developed indigenously, is expected to play a crucial role in protecting the 10-20 age group, who are most susceptible to severe dengue cases.

“We are waiting for the results of the trials, and once the vaccine is recommended by the NTAGI, the system will be ready to adopt it,” said Dr. Arora.

Also read: World Immunization Week: Vaccines Are Like Insurance, They’re Safe—Take Them, Says Dr NK Arora | Exclusive

India In The Forefront of Vaccine R&D

Dr. Arora stated that India, known as the pharmacy of the world, is playing a significant role in the global vaccine landscape.

“One feels very proud to be an Indian as every vaccine administered in India is made in India,” he said, noting that India also "provides two-thirds of the global vaccine supply".

This achievement positions India as a global leader in vaccine research and development, contributing substantially to global health initiatives.

"These initiatives are vital for the future of public health in India," Dr. Arora said.