Algerian Olympic boxer Imane Khelif, who won the gold medal in the women's 66kg boxing category at the 2024 Paris Olympics, has found herself in the middle of a gender-related debate. Reports accessed by French journalist Djaffar Ait Aoudia, as published in Reduxx, brought to light medical findings about Khelif's biological status, revealing that Khelif has "testicles" and an XY chromosome arrangement, thus confirming as 'biologically male'.

According to this report, Khelif has a medical condition known as 5-alpha reductase deficiency (5-ARD), a rare difference in sex development (DSD). Medical documents, allegedly from collaborations between France’s Kremlin-Bicêtre Hospital and Algeria’s Mohamed Lamine Debaghine Hospital, were reportedly compiled in June 2023. These reports outline that Khelif has internal testes and other characteristics atypical for female development.

An MRI and chromosomal tests confirmed the absence of a uterus and the presence of internal male reproductive organs. Furthermore, her testosterone levels were consistent with typical male ranges.

What are DSD?

DSD comprise the group of congenital conditions characterized by lack of typical sex development. In most cases, DSD can be identified in prenatal development due to interactions between complex genetic factors and hormone signals. Sometimes, people use the older term and refer to DSD as "intersex," while at other times they use some precise vocabulary to describe a given condition.

But first, what is 'Sex' and 'Gender'?

The terms "sex" and "gender" tend to be used almost interchangeably; however, they refer to two different things. "Sex" generally relates to the physical qualities determined by genetics and hormone influence, whereas "gender" refers to a human being's identity and social construction. DSD conditions can usually obscure the distinctions that are typical for sex, making talk around these terms particularly tricky.

DSD: Shattering genetic factors, Sex hormones and Genitalia

Genetic Factors

The genetic factors form the core of DSD conditions. Normally, a human being has 46 chromosomes, two of which decide the sex of the individual-the X and Y chromosomes. In most females, two X chromosomes are found, but in most males, an X and a Y chromosome are found. DSD can cause variations in such chromosomal patterns and hence sometimes lead to incongruity between chromosomal sex and physical attributes.

Sex Hormones

Sex hormones, including androgens in males and estrogens in females, determine body development both in fetal life and at puberty. Such hormones are produced in gonads, which could be either testes in a male or ovaries in a female, as prescribed by the genetic pattern. Hormonal pathways may therefore get affected in DSD such that sexual characteristics might appear in an atypical fashion.

Body Parts of Reproduction

DSD may result in the combination of male and female reproductive structures or in reproductive parts not typical male or female. A few have mixed genitals, but others may have typical genitals yet possess an unusual chromosomal setup that reveals itself at puberty or even later.

DSDs are as diverse as are the individuals affected by them. For example, some can be mentioned to be the following:

- In this case, one finds an individual with an XY chromosome yet having female-like external genitals.

- In other words, one has XX chromosomes but with male-like genitals.

- One can still have both ovarian and testicular tissues, meaning in such a case, you are likely to have genitals which might be a mix of a male and female.

- Some individuals have normal sex organs but an atypical arrangement of chromosomes, meaning changes in physical development over time.

The Cleveland Clinic notes that "intersex" has been the term used for decades in describing DSDs; however, terminology may vary among individuals and cultures. Some people with DSD prefer terms like 'differences' instead of 'disorders', arguing that DSD is just a variation in biological development.

According to a report in The Independent, "If I showed you pictures of my patients without any clothes on, you would say, well, these are females that I'm looking at," said Prof Højbjerg Gravholt, professor of genetic endocrinology in Denmark and works with patients who have differences in sex development.

He mentions that physical characteristics, hormonal profiles, or chromosomes cannot determine a person's sex uniquely. DSD in the lives of many presents the message that sex is not a biological category but rather a spectrum molded by genetic and hormonal diversity.

What Causes Disorders of Sex Development?

DSDs are caused by variations in genes that control sexual development or altered response to hormones such as those found in CAH. CAH presents as a result of excess androgen production with the development of male characteristics. Another type of DSD is the AIS where the body system is unable to respond to the presence of androgens thereby modifying physical development.

Is there a Treatment for DSD?

According to Cleveland Clinic, treatment of DSD is given based on the severity of the symptoms. These can vary from:

-Hormonal therapy for puberty and other conditions that may arise in connection with DSD, including osteoporosis.

-Genital reconstruction or modification surgery. Most of the surgeries are irreversible and thus left until the patient is capable of giving consent. For the very mild cases of DSD, no treatment is necessary and the individual may lead an untreated life.

Is It Possible to Prevent DSD?

Currently, DSDs can't be prevented. What is not well understood at present is the complex gene interactions that drive the development of human sex. No method has been developed that can predict or avoid DSDs in future offspring. That unpredictability reflects the normal variation in human biology.

Having a morning coffee to start your day, or a midday coffee to keep your day going, is the best feeling. It energizes you and helps you get through the day. But have you ever noticed how you are left with sour notes in your mouth and a foul smell. Does that mean you have bad hygiene or is it an indicator that you should not be having coffee?

The answer is neither, it is due to some compounds in the coffee. You may have noticed that this is the case with many other strong-tasting foods like garlic, onions, boiled chicken and other dairy products. The Mayo Clinic explains that food particles breakdown around your teeth leads to more bacteria and causes a bad smell. These foods enter the blood stream after you ingest, get carried to your lungs and affect one’s breath.

While it may seem like a minor issue, it can be noticeable to others and make us feel self-conscious. So, it's important to understand why coffee causes bad breath and what we can do to get rid of it.

Why Does Coffee Make Our Breath Smell

When coffee beans are roasted, they release certain chemicals that contain sulfur. According to MedlinePlus these sulfur compounds are a big reason why coffee makes your breath smell bad. Think of it like the smell of rotten eggs, but much milder. Coffee is also acidic, which means it can change the pH balance in your mouth, making it easier for bacteria to grow.

When bacteria grow, they release even more smelly sulfur compounds. On top of that, coffee can dry out your mouth. Caffeine acts a little like a dehydrating agent, and coffee also contains tannins, which stop your mouth from making enough saliva. Saliva helps wash away bacteria and food particles, so when your mouth is dry, these things stay around and cause bad breath.

How To Fix This Issue?

The best way to avoid coffee breath is to make some smart choices about how you drink your coffee. Experts suggest drinking black coffee, without any milk or sugar, is better for your breath. Milk and sugar can feed the bacteria in your mouth, making the smell worse. If you must add flavor, try stirring your coffee with a cinnamon stick or a vanilla bean. These natural flavorings can add a nice taste without causing bad breath. If you need a sweetener, try using sugar substitutes instead of regular sugar. If you have to use dairy, whole milk or half and half are better than skim milk, as skim milk contains more sugar.

If you're willing to try something other than coffee, there are some good alternatives that can still give you a caffeine boost. High-caffeine black tea or chai tea can provide a similar pick-me-up without the strong coffee smell.

Whether you drink coffee or not, good oral hygiene is essential for fresh breath. The sulfur compounds, acidity, and tannins in coffee can all contribute to bad breath. So, it's important to brush your teeth twice a day, floss regularly, and use mouthwash. If you drink coffee, you might need to pay extra attention to your oral hygiene

Democratic Senator Cory Booker completed the longest speech in America's history, which lasted for 25 hours. How did he prepare for it? To endure standing and talking for 25 hours takes a lot of preparation and strategy. So, what did Cory Booker do to ensure he maintained his body's energy and hydration levels?

Starting from a few days leading to the big day of the speech, he started for days leading up to the speech, limiting both food and water intake. His primary concern was to avoid the need of a bathroom break. This would mean that you would yield the floor, and end his historic speech in between.

Booker abstained food to eliminate the risk of digestion-related discomforts like bloating or hunger pangs mid-speech. Medical experts however suggest that this approach has downsides, such as muscle fatigue and electrolyte imbalances.

Mental and Physical Conditioning

Booker is also known for his dedication to fitness. He has relied on his physical endurance to sustain himself through the speech. His preparation also showed that his training for marathon in ways have helped him. As per reports, he used breathing techniques and mindfulness to maintain focus and combat fatigue.

Furthermore, his heart rate was tracked by his Oura ring, which shot up to over 100 bears per minute at one point. This prolonged elevated heart rate indicated the physical strain his body was under. This was similar to what happens during an extended physical activity.

Nutrient Deprivation

Medical professionals also emphasized the importance of proper hydration and electrolyte balance before prolonged physical exertion. Booker, however did the opposite, he actually reduced his water intake to avoid urination. This also led to cramping, which is a common symptom of dehydration. Without adequate fluid intake, his muscles lacked the necessary hydration to function efficiently, leading to tightness and discomfort.

Experts also noted that fasting for days before the event likely caused a depletion of glycogen stores, the body’s primary energy reserve. Without sufficient carbohydrates or fats for energy, Booker would have relied on sheer willpower and metabolic efficiency to sustain his performance.

ALSO READ: Senator Cory Booker's Longest Speech In History Criticizes Trump's Health Policy, Details Inside

How His Body Reacted?

Booker admitted to experiencing muscle cramps toward the end of his speech. These were likely due to prolonged standing and dehydration. Medical professionals warn that such extreme dehydration could have caused more severe issues, such as kidney problems, urinary tract infections, or even fainting.

Despite completing his speech, Booker struggled to sleep afterward. His mind remained active, and his body, still processing the stress and exhaustion, made it difficult for him to rest. He reported feeling “loopy” after reaching home, a symptom often associated with extreme fatigue and sleep deprivation.

Experts recommend gradually replenishing fluids and nutrients after extreme exertion. Booker took steps in this direction by consuming a banana and drinking water post-speech. Doctors suggest that an ideal recovery diet should include electrolyte-rich fluids, easily digestible foods like rice or broth, and a slow reintroduction of solid meals to restore depleted energy reserves.

Standing for prolonged periods can lead to blood pooling in the lower extremities, which may cause dizziness or fainting. Additionally, resisting the urge to urinate for such an extended period could have long-term repercussions for bladder health. Given his fitness level, Booker is expected to recover fully, but his speech took a clear toll on his body.

Aging is a natural process that comes with time. Everyone has to age, but it is a scary concept for many to accept. Kids growing up to be adults, adults reaching middle age and so on and forth. Many things change about you when you age. You will be wiser and have a lot more experience. However, there are many other changes that our bodies go through when we age. Women especially are discouraged to speak about their struggles and the way they are affected by the changes in their body. However, speaking about these things can help you not only prepare, but also learn more about how to avoid and get ahead of certain things

What Unexpected Changes Occur In Women

There are a few common things that most of us expect as we age. For example, weight gain with age, decline in muscle mass, risk of heart diseases and diabetes. However, there are many unexpected changes that also happen.

Pelvic Changes

Even after your bones stop growing as a teenager, your pelvis keeps getting wider. This happens in both men and women, but it's especially important for women. A 2022 study published in Anthropol Anz. explains that during pregnancy, your pelvis changes even more. It widens and tilts forward to get ready for your baby to be born. Your body makes these changes to make childbirth easier. While the ligaments around your pelvis stretch, the actual shape of the bone doesn't change.

Heart Health

While women who do not drink alcohol and smoke are less likely to develop heart diseases, research has shown, menopausal women are more likely to develop cardiovascular issues. A 2021 study published in the Oxidative Medicine and Cellular Longevity showed that estrogen has a protective effect on the cardiovascular system. The lack of estrogen that happens with menopause can trigger heart issues for them.

Women Shrink More

When you're a kid, you get taller. But as you get older, you start to get shorter. This happens to everyone, but women tend to lose more height than men. This is because men usually have more muscle and stronger bones. A study published in the American Journal of Epidemiology showed that women start losing height around age 30, and it keeps happening as they get older. So, you might find yourself a little shorter as you age, and need help reaching high shelves.

Vaginal pH self regulates

Your vagina is very good at cleaning itself. It has a natural balance called pH, which is usually a little acidic. A 2021 review in the Diagnostics explains that this acidic balance helps keep bad germs away. Your vagina doesn't need harsh soaps or douches to stay clean. These can mess up the natural balance and cause problems. Warm water and gentle cleansers are usually enough to keep the outside clean. Your body knows how to take care of the inside.

Different Response To Stressful Situations

We all have our own different ways of dealing with fear. While some people shut down, others can be quick. However, research shows that there may be a biological factor in this. A 2019 study published in the European journal of neuroscience explains that women's brains seem to process fear differently than men's, which might explain why they're more prone to anxiety disorders. Scientists are now studying this to find better ways to help.