Diabetes insipidus (DI) is a rare medical condition that disrupts the body's ability to regulate water, resulting in excessive thirst and an unusually high volume of urine. This condition affects the kidneys' ability to concentrate urine and causes individuals to produce between 3 and 20 quarts of dilute, colourless urine daily, compared to an average of 1 to 2 quarts. It is pertinent to note that DI is not related to diabetes mellitus, which disrupts the body's insulin production.

Types Of Diabetes Insipidus

This condition results from damage to the hypothalamus or pituitary gland, which impairs the production or release of vasopressin, a hormone responsible for water retention. When vasopressin levels are inadequate, the kidneys fail to conserve water, leading to excessive urination. It can result from Brain injuries or surgeries, tumours, infections or inflammation and aneurysms.

Nephrogenic Diabetes Insipidus

This type occurs when the kidneys fail to respond to vasopressin, causing excessive fluid loss. Common triggers include chronic kidney disease, and electrolyte imbalances, such as high calcium or low potassium levels. Additionally, medications like lithium

and urinary tract blockages can also cause Nephrogenic DI.

Gestational Diabetes Insipidus

A rare condition seen only during pregnancy, this occurs when the placenta produces an enzyme that breaks down vasopressin or increases prostaglandin levels, reducing kidney sensitivity to the hormone. Symptoms of this are usually mild and often resolve postpartum but can recur in future pregnancies.

Symptoms And Warning Signs

• Severe thirst, often leading to the consumption of over a gallon of water daily
• Frequent urination (polyuria), sometimes exceeding 20 quarts per day
• Nighttime urination and bed-wetting
• Weakness, muscle pain, and preference for cold drinks

In severe cases, dehydration may develop, manifesting as fatigue, dizziness, dry mouth, confusion, nausea, or fainting. Infants and children with DI may exhibit crankiness, poor feeding, slow growth, fever, or vomiting.

Causes And Risk Factors

DI stems from issues with vasopressin production or response. Central DI arises from damage to brain structures, while nephrogenic DI relates to kidney dysfunction. Risk factors include:

- Genetic mutations affecting water regulation

- Certain medications like diuretics or lithium

- Metabolic disorders that alter calcium or potassium levels

- Brain injuries or surgeries

Diagnosis And Testing

Diagnosing DI involves a combination of medical history, physical exams, and specialized tests:

- Urinalysis: Evaluates urine concentration and glucose levels to distinguish DI from diabetes mellitus.

- Blood tests: Check electrolyte, glucose, and vasopressin levels.

- Water deprivation test: Measures changes in weight, blood sodium, and urine concentration during fluid restriction.

- MRI: Detects abnormalities in the hypothalamus or pituitary gland.

- Genetic screening: Identifies inherited risk factors.

Although DI is rare, affecting about 1 in 25,000 people, early diagnosis and targeted treatment can significantly improve quality of life. Researchers continue to explore its causes and treatments to better support those living with this challenging condition.

Oral Rehydration Solution (ORS) is one of the simplest yet most effective life-saving solutions that every household should keep readily available, doctors said on World ORS Day.

Observed every year on July 29, World ORS Day raises awareness about the importance of ORS—a scientifically formulated mix of glucose and electrolytes, including sodium and potassium—that helps prevent and treat dehydration caused by diarrhea, vomiting, fever, heat, and excessive sweating.

First introduced in 1969, ORS has transformed the treatment of dehydration worldwide. Since 2003, the World Health Organization (WHO) and UNICEF have recommended a low-osmolarity ORS formula, which improves fluid absorption and reduces the need for intravenous fluids. Today, ORS remains the gold standard for preventing and treating dehydration, particularly in children and people living in resource-limited settings.

ORS Prevents Dehydration, It Doesn't Treat the Illness

Dr. Ranjana Bhatt, Associate Director - Internal Medicine, Paras Health, Panchkula, told HealthandMe that ORS is not a medicine that cures the underlying illness but is designed to prevent and correct dehydration.

Dehydration occurs when the body loses more water and electrolytes than it takes in, most commonly due to diarrhea or vomiting. It can develop rapidly, especially in young children, older adults, and people with chronic illnesses.

Why ORS Works Better Than Water

ORS works through a well-established biological process in the small intestine. It contains the right balance of glucose and sodium, which are absorbed together through special proteins called sodium-glucose cotransporters (SGLTs). As sodium enters the bloodstream, water follows, allowing the body to rehydrate efficiently.

This mechanism makes ORS more effective than plain water—and often more effective than many commercial sports drinks—for replacing lost fluids and electrolytes quickly and safely.

"Recognizing the early signs of dehydration, such as excessive thirst, dry mouth, dizziness, reduced urination, and unusual fatigue, and starting ORS promptly can prevent serious complications. On ORS Day, we encourage every family to make ORS a household essential and use it appropriately while seeking timely medical care whenever symptoms are severe or persistent," Dr. Bhatt said.

Why Every Household Should Keep ORS

Dr. Amit Prakash Singh, Consultant - Internal Medicine, CK Birla Hospital, Delhi, told HealthandMe that ORS is one of the simplest, most affordable, and most effective ways to prevent dehydration.

"ORS is accessible for almost everyone, and the product is recommended by the World Health Organization to start treating dehydration caused by diarrhea at home. Having ORS packets at home enables treating dehydration without going to the doctor first and potentially avoiding hospitalization," he said.

When Should You Use ORS?

Besides diarrhea, ORS can help replace fluids and electrolytes lost due to:

• Fever-related dehydration
• Vomiting and gastroenteritis
• Heat exhaustion and heatstroke
• Heavy sweating after strenuous exercise
• Hangovers caused by dehydration
• Viral illnesses such as dengue
• Dehydration in older adults and people with chronic illnesses.

"ORS is not just for diarrhea. Whenever there is a lot of fluid loss or electrolyte loss, ORS can be used. ORS can be consumed for vomiting due to gastroenteritis, food poisoning, or viral infection (provided the person can sip small amounts repeatedly)," Dr. Singh said.

ORS Is Not A Cure

Doctors caution that ORS only replaces lost fluids and electrolytes—it does not treat the underlying disease.

It may help prevent dehydration after fever, vomiting, or excessive sweating, but it is not a treatment for abdominal pain, acidity, indigestion, constipation, gastritis, or irritable bowel syndrome (IBS). Persistent or severe symptoms should always be evaluated by a healthcare professional, Dr Singh said.

How To Identify Original ORS

When buying ORS, check the following:

• Look for packaging that states "WHO Recommended Formula." Any other mark or logo may not indicate a WHO-recommended ORS formulation.
• Read the label carefully. Some products may be marketed as "Ready-to-Serve Fruit Beverage" or carry a disclaimer such as: "This is only a trademark and does not represent its true nature. Not a WHO Oral Rehydration Salts." These products are not WHO-recommended ORS.
• Check the ingredients. Genuine ORS should contain glucose, sodium, and potassium in the recommended proportions.

Liver disease is unusual among serious conditions in that it can progress significantly without producing symptoms that would prompt most people to seek medical attention. Hepatitis, which is inflammation of the liver, is the most common starting point for that progression.

It may be caused by viral infections including Hepatitis B and Hepatitis C, excessive alcohol consumption, fatty liver disease, certain medications, or autoimmune conditions. In many cases, the person carrying it feels entirely well while damage accumulates over months and years.

How Chronic Inflammation Causes Lasting Liver Damage

The liver does regenerate, but that capacity has limits. When inflammation persists, healthy liver cells are progressively replaced by scar tissue, a process called fibrosis.

Continued scarring eventually produces cirrhosis, where the liver loses its structural integrity and its ability to perform the functions the body depends on it for, such as processing toxins, producing proteins involved in blood clotting, regulating metabolism, and supporting digestion. At this stage, the damage is largely irreversible.

The timeline from hepatitis to cirrhosis typically spans years or even decades, which is precisely what makes delayed diagnosis so consequential. Each year of untreated inflammation is a year of accumulated scarring.

By the time cirrhosis produces obvious symptoms such as jaundice, abdominal swelling from fluid accumulation, internal bleeding from enlarged veins in the oesophagus, cognitive changes from toxin build-up, kidney involvement, the disease has already reached an advanced stage. Cirrhosis also carries a significantly elevated risk of liver cancer.

Also read: Smoking, Diabetes, High Blood Pressure May Fuel the Most Dangerous Type of Artery Plaque, Study Finds

Early Detection Can Prevent Disease Progression

The clinical picture is meaningfully better when liver disease is identified early. Effective antiviral medications can control chronic Hepatitis B and cure most cases of Hepatitis C, substantially reducing the risk of progression.

Fatty liver disease, when caught before significant fibrosis has occurred, can often be reversed through weight management, blood sugar control, reduced alcohol intake, and consistent physical activity. These interventions are accessible, evidence-based changes that work when applied before the disease has advanced.

Screening is where early identification happens. Blood tests measuring liver enzymes and imaging studies can detect liver inflammation and early fibrosis well before symptoms appear.

For individuals with diabetes, obesity, a family history of liver disease, a history of blood transfusions, or other known risk factors, periodic liver assessment is a practical and important part of routine care rather than an optional precaution.

Also read: IIT Delhi, AIIMS Develop First Hindi Music Therapy for Stroke Patients: How Survivors Find Their Voice

Who Should Get Screened And Why It Matters

The pattern that gastroenterologists consistently encounter is patients presenting with advanced liver disease who had risk factors identifiable years earlier. Hepatitis B and C are both detectable through simple blood tests.

Fatty liver shows up clearly on ultrasound. The window for effective intervention exists, and it is considerably wider earlier in the disease than most people assume when they have never been tested.

This draws attention to a disease that carries a substantial global burden but remains widely undertreated because it does not announce itself. For anyone with known risk factors, or who has never had their liver function assessed, the appropriate response to that is a conversation with a physician, before symptoms, rather than after.

By Dr. Saswata Chatterjee, Senior Consultant – Gastroenterology, CMRI Hospital

Smoking, diabetes, high blood pressure, high cholesterol, and obesity have always been recognized as major risk factors for heart disease.

New research has emerged saying these preventable conditions may do more harm than simply contribute to plaque buildup in the arteries. They may also encourage the formation of the most dangerous type of plaque, the kind that is most likely to rupture and trigger a massive heart attack.

The findings, presented at the European Society of Cardiology (ESC) Congress 2026, show that people with a greater number of modifiable cardiovascular risk factors were more likely to have widespread coronary plaque.

They may also have unstable and vulnerable plaques that can suddenly rupture, disrupting blood flow to the heart.

More Risk Factors = More Dangerous Plaques

Researchers analyzed coronary artery imaging data to understand how both modifiable and non-modifiable cardiovascular risk factors affect the characteristics of plaque.

The study found that patients with a higher burden of modifiable risk factors had plaques distributed across all three major coronary arteries.

More importantly, these individuals were more likely to develop lipid-rich plaques with thin fibrous caps, a trait of vulnerable plaques that are more likely to rupture.

On the other hand, people whose risk profile was dominated by non-modifiable factors, such as age or genetics, tended to have more stable plaque types.

"Our findings suggest that modifiable cardiovascular risk factors are associated not only with a greater amount of coronary plaque but also with more vulnerable plaque characteristics that are linked to future heart attacks," the researchers said.

Also read: ICMR Study Highlights India’s Silent Cholesterol Crisis: 9 In 10 Adults Have At Least One Abnormal Blood Lipid

Why Vulnerable Plaque Is Especially Dangerous?

Some plaques gradually harden and remain relatively stable for years, causing slow narrowing of the arteries. Others contain large amounts of fat covered by a very thin protective layer known as a fibrous cap.

These unstable plaques can rupture unexpectedly, prompting blood clots to form and suddenly block an artery, leading to a heart attack or stroke.

According to the researchers, individuals with multiple preventable cardiovascular risk factors were significantly more likely to have these high-risk plaques.

Also read: Risks Of Plastic Pollution: Study Finds Microplastics In Heart Arteries Can Cause Severe Heart Attacks

Smoking, Diabetes And high Blood Pressure Pose High Risk

Smoking chronically damages the inner lining of blood vessels, making it easier for cholesterol deposits to accumulate while also promoting inflammation and blood clot formation.

High blood pressure places constant stress on artery walls, accelerating plaque development and increasing the likelihood of rupture.

When several of these risk factors occur together, their harmful effects can compound, increasing both the quantity of plaque and likelihood to rupture.

Also read: Vapers & Smokers Have Equally Poor Physical Fitness & Blood Vessel Health, Study Finds

What Is Atherosclerosis?

Atherosclerosis is a chronic condition in which fatty deposits made up of cholesterol, inflammatory cells, calcium, and other substances accumulate inside artery walls.

Over time, these deposits narrow the arteries and reduce blood flow to vital organs. The condition often develops silently over decades before causing symptoms.

If a plaque ruptures, a blood clot can rapidly block blood flow, resulting in a heart attack or stroke. Smoking, diabetes, high blood pressure, obesity, and elevated LDL ("bad") cholesterol are among its leading preventable causes.

The researchers said the study highlights the importance of early identification and management of modifiable cardiovascular risk factors through smoking cessation, blood pressure control, diabetes management, cholesterol-lowering treatment, regular physical activity, a healthy diet, and maintaining a healthy weight.