Diabetes insipidus (DI) is a rare medical condition that disrupts the body's ability to regulate water, resulting in excessive thirst and an unusually high volume of urine. This condition affects the kidneys' ability to concentrate urine and causes individuals to produce between 3 and 20 quarts of dilute, colourless urine daily, compared to an average of 1 to 2 quarts. It is pertinent to note that DI is not related to diabetes mellitus, which disrupts the body's insulin production.

Types Of Diabetes Insipidus

This condition results from damage to the hypothalamus or pituitary gland, which impairs the production or release of vasopressin, a hormone responsible for water retention. When vasopressin levels are inadequate, the kidneys fail to conserve water, leading to excessive urination. It can result from Brain injuries or surgeries, tumours, infections or inflammation and aneurysms.

Nephrogenic Diabetes Insipidus

This type occurs when the kidneys fail to respond to vasopressin, causing excessive fluid loss. Common triggers include chronic kidney disease, and electrolyte imbalances, such as high calcium or low potassium levels. Additionally, medications like lithium

and urinary tract blockages can also cause Nephrogenic DI.

Gestational Diabetes Insipidus

A rare condition seen only during pregnancy, this occurs when the placenta produces an enzyme that breaks down vasopressin or increases prostaglandin levels, reducing kidney sensitivity to the hormone. Symptoms of this are usually mild and often resolve postpartum but can recur in future pregnancies.

Symptoms And Warning Signs

• Severe thirst, often leading to the consumption of over a gallon of water daily
• Frequent urination (polyuria), sometimes exceeding 20 quarts per day
• Nighttime urination and bed-wetting
• Weakness, muscle pain, and preference for cold drinks

In severe cases, dehydration may develop, manifesting as fatigue, dizziness, dry mouth, confusion, nausea, or fainting. Infants and children with DI may exhibit crankiness, poor feeding, slow growth, fever, or vomiting.

Causes And Risk Factors

DI stems from issues with vasopressin production or response. Central DI arises from damage to brain structures, while nephrogenic DI relates to kidney dysfunction. Risk factors include:

- Genetic mutations affecting water regulation

- Certain medications like diuretics or lithium

- Metabolic disorders that alter calcium or potassium levels

- Brain injuries or surgeries

Diagnosis And Testing

Diagnosing DI involves a combination of medical history, physical exams, and specialized tests:

- Urinalysis: Evaluates urine concentration and glucose levels to distinguish DI from diabetes mellitus.

- Blood tests: Check electrolyte, glucose, and vasopressin levels.

- Water deprivation test: Measures changes in weight, blood sodium, and urine concentration during fluid restriction.

- MRI: Detects abnormalities in the hypothalamus or pituitary gland.

- Genetic screening: Identifies inherited risk factors.

Although DI is rare, affecting about 1 in 25,000 people, early diagnosis and targeted treatment can significantly improve quality of life. Researchers continue to explore its causes and treatments to better support those living with this challenging condition.

This Is Endometriosis, a 2024 intimate, expressive film by Georgie Wileman and Matt Houghton won a BAFTA Award 2026 for Best British Short Film. This 19.27 minute long film shows how Georgie was robbed of her time due to endometriosis. The film sets in present-day narrative with memories from her past.

Endometriosis is a condition, that Georgie notes is often dismissed by many doctors as just "painful periods". However, her film portrays how truly disabling this medical condition. It is a condition in which cell similar to the lining of the uterus or the endometrium, grow outside the uterus. It affects 1 in 10 born with a uterus and could cause pain, often "worse than the last stages of child labour", notes thisiseno.com, the official website of the short film. Around 190 million people worldwide are impacted by the condition, however, what the film points out is how "dangerously underfunded, under researched and misinformed" doctors continue to remain despite the condition being so widespread.

Read: A Woman Lost Her Ovary To Endometriosis Surgery After Receiving An Ultimatum From Gynecologist

A Film That Documents Personal Struggle

Georgie, while accepting the award wore a symbolic blood-red gown. She said, "It was surreal and beautiful. Knowing how much this win would mean to the [endometriosis] community made it an emotional moment."

She points out that it is more than just a "painful period" and that "It is a full body disease. It important for people to understand the severity of the pain – it’s widely considered to be worse than childbirth." What is shocking is that it takes an average of eight to 10 years to be diagnosed.

She shares being "bed-bound for three months" when she was only 13. She said it first got "really bad" and she was not believed for long time. "It took me a long time to even believe myself. I was just so angry at my body for not working."

While she had been in and out of wheelchair, she was not formally diagnosed with endometriosis until she was 26, and then at 29, she was diagnosed with its 'sister disease' adenomyosis. She has undergone seven surgeries for her endometriosis and a hysterectomy for adenomyosis.

Read: Keltie Knight Was Gaslit By Doctors For Years Before Getting A Hysterectomy

In 2020, after years of feeling dismissed by doctors and watching her condition be misunderstood in the media, she decided she had had enough. That frustration pushed her to tell the story herself.

“It began as a photography project,” Wileman says. “And it meant a lot to people because, for the first time, they felt their experiences were being shown truthfully.”

But she soon realized that still images could only go so far. “There’s only so much a photograph can capture,” she adds.

Why Does It Take So Long For An Endometriosis Diagnosis?

A study published in Obstetrics and Gynecology journal looks at the factors of what leads to such a delay in endometriosis diagnosis. Researchers identified that factors include normalization of menstrual pain, the diversity of symptoms, and a lack of training and prompt referrals among healthcare professionals lead to this delay.

At an individual level, the researchers found that many women struggled to tell the difference between “normal” period pain and something more serious. A common belief was that painful periods were simply part of being a woman and had to be endured. As a result, many relied on self-care measures and delayed seeking medical help, which likely pushed back the timeline for an endometriosis diagnosis.

On an interpersonal level, stigma played a powerful role. Menstrual problems were often seen as too private or embarrassing to talk about. At the same time, society’s tendency to normalize period pain meant that symptoms were minimized, both by those experiencing them and by people around them. This silence and normalization further contributed to delayed diagnoses.

Barriers also existed within the healthcare system itself. Some participants said their general practitioners dismissed their concerns or appeared unfamiliar with endometriosis. Healthcare professionals involved in the study acknowledged gaps in their own training and pointed out the lack of clear clinical guidelines for diagnosing the condition.

Doctors also noted that endometriosis symptoms can overlap with other disorders, making it harder to identify. Diagnosis is particularly challenging because there is no simple, noninvasive test that can confirm the condition with certainty. Delays in referrals were common. One contributing factor was the widespread belief that laparoscopic surgery is the only definitive way to diagnose endometriosis. Some healthcare providers also questioned how useful a formal diagnosis would be, which further slowed the process.

Dr Sophie Davenport, a doctor in England who conducted the research as part of her Master of Public Health dissertation, emphasized that the problem is layered and requires solutions at multiple levels.

“The key highlights of the data are that delays to diagnosis exist throughout the journey,” she explained. “We need to address these at different levels — from society understanding what ‘normal’ menstruation looks like and being open about menstrual problems, to clinicians being well educated, up to date on how endometriosis presents and diagnosed, and truly listening when patients say their periods aren’t normal.”

Squirrels could be natural hosts of the mpox virus (MPXV) -- that causes monkeypox disease -- according to a recent study by German researchers.

The team from the Helmholtz Institute for One Health (HIOH) identified the fire-footed rope squirrel (Funisciurus pyrropus) as a likely natural reservoir of the MPXV.

The study published in the journal Nature revealed that sooty mangabeys – a primate found in West Africa -- can contract mpox by eating infected squirrels. The disease may present mild lesions, but it can also cause more severe skin lesions or even be fatal.

"Identifying the animal sources of the virus and the exposure routes that lead to inter-species transmission are key steps towards understanding spillover mechanisms and developing effective prevention measures to mitigate the risk of transmission to humans," said Livia V. Patrono, one of the senior authors at HIOH.

Squirrels Suspected MPXV Hosts

While squirrels have long been suspected as potential reservoirs for MPXV, their role was confirmed after an investigation of an mpox outbreak among wild sooty mangabeys (Cercocebus atys) in Côte d'Ivoire.

During the outbreak, reported in early 2023, nearly one-third of the primates showed clinical signs of disease, and four infants died.

The team conducted viral genome sequencing and found that the infected monkeys carried a virus that was nearly identical to an MPXV strain identified in a fire-footed rope squirrel found dead 12 weeks earlier nearby.

Further, the team analyzed fecal samples from the mangabeys. A sample collected eight weeks before the outbreak's onset contained DNA from both the virus and the rope squirrel. This provided strong evidence of interspecies transmission at that moment.

Sooty mangabeys have been previously observed catching and eating fire-footed rope squirrels, which provide a direct route for the transmission of viruses.

Mpox Continues To Spread Globally

Although mpox is no longer a public health emergency, outbreaks of clade I and clade II strains of the mpox virus are continuing in many countries around the world, especially in Africa.

Last week, Madagascar announced the country's first death from mpox, a 3-year-old girl from the island nation’s eastern city of Toamasina.

The WHO has also confirmed that two cases of the recombinant strain – combining genomic elements of clades Ib and IIb of the monkeypox virus (MPXV) – have been identified to date: one in the United Kingdom and one in India.

Mpox is an infectious disease caused by the monkeypox virus (MPXV), part of the Orthopoxvirus genus, which also includes the virus that causes smallpox.

It spreads through close physical contact, including sexual contact, and in some cases through contaminated materials or respiratory droplets.

Symptoms typically include fever, swollen lymph nodes, rash, and/or lesions.

The global health body has also urged all countries to “remain alert to the possibility of MPXV genetic recombination.” It has also urged for continued epidemiological surveillance, sequencing, vaccination of at-risk groups, and infection prevention and control measures.

An international group of scientists has created an artificial intelligence tool that can estimate a woman’s likelihood of developing breast cancer within the next four years.

The AI tool, known as the BRAIx risk score, analyzes mammogram images to generate an individualized risk assessment and flag women who may face a higher chance of developing the disease.

It may not only show the current risk but also predict the future risk, enabling early detection and treatments for a better outcome.

According to the findings published in The Lancet Digital Health journal, nearly one in 10 women ranked in the top 2 percent of risk by the AI tool were diagnosed with breast cancer within four years. This was despite previously receiving a clear screening result.

“These risk scores enable future development of personalized screening pathways to transform population breast cancer screening and save lives,” said corresponding author Helen M. L. Frazer of the University of Melbourne.

Frazer noted that identifying women who appear cancer-free but carry very high risk -- comparable to those with inherited BRCA1 or BRCA2 mutations -- will unravel both hereditary and non-hereditary causes of breast cancer.

From one-size-fits-all screening to personalization

Breast cancer screening programs have significantly lowered mortality rates -- by roughly 40-50 percent among women aged 50 to 74. However, most screening systems still apply the same approach to all women, regardless of individual risk.

Traditional screening tools use genetics, breast density, and questionnaires to estimate breast cancer risk. On the other hand, new AI-based screening tools, such as BRAIx personalizes screening by gathering information already present in breast scan images to better identify who is at higher risk.

“Our results show that conventional mammographic density is a far weaker predictor of breast cancer risk than the BRAIx risk score, even for interval cancers,” the researchers said in the paper. Interval cancers are aggressive tumors diagnosed after a negative mammogram.

The BRAIx Tool

The BRAIx risk score was developed using mammograms from nearly 400,000 women. To prove its efficacy, the AI tool was tested on data from almost 96,000 women from Australia and then confirmed in an independent Swedish population of over 4,500 women.

The findings showed that:

• The BRAIx risk score estimated breast cancer risk more accurately than the traditional risk factors, such as breast density, country of birth, and even family history.

• For the top 2 percent of women with the highest BRAIx risk score, the probability of a cancer diagnosis within 4 years was 9.7 percent -- a risk level exceeding that typically seen in women with inherited BRCA1 or BRCA2 mutations.

The BRAIx risk score can:

• Make breast screening more personalised,
• Improve early cancer detection,
• Reduce false alarms,
• Save lives without increasing costs

Global Breast Cancer Burden

Breast cancer continues to be the most common cancer among women worldwide.

A recent study published in The Lancet Oncology journal predicted that the number of new cases of the deadly disease will reach more than 3.5 million globally in 2050 -- rising by a third from 2.3 million in 2023.

Annual deaths from the disease will also rise by 44 percent -- from around 764,000 to 1.4 million.

However, not smoking, getting sufficient physical activity, lowering red meat consumption, and having a healthy weight can help prevent over a quarter of healthy years lost to illness and premature death from breast cancer.