A condition, known commonly as "black urine disease" or Alkaptonuria is a rare genetic disorder involving protein metabolism, and it has its root in the mutation of the homogentisate 1,2-dioxygenase gene, which in turn causes homogentisic acid accumulation in the body. The appearance of dark urine after exposure to air is due to this kind of accumulation; however, a variety of symptoms can be expected, such as joint stiffness, changes in pigmentation, and other long-term health complications. Although the prevalence has been estimated to be between 1 in 250,000 and 1 in 1 million people in the United States, its effects are indeed high on those affected.

Alkaptonuria is an autosomal recessive disease, meaning that the child must inherit a defective copy of the HGD gene from both parents. If both parents are carriers, their offspring have a 25% chance of inheriting two faulty genes and developing alkaptonuria. The condition is genetic but is often not diagnosed for years because it progresses slowly and its early symptoms appear to be harmless.

Symptoms of Alkaptonuria

The most characteristic and common initial symptom of alkaptonuria is dark urine. The reason for this is due to the fact that excess HGA is excreted in the urine and upon oxidation in the presence of air, it gives the urine a brown or black color. Though it is often considered cosmetic, the long-term accumulation of HGA within the connective tissues produces more complicated health problems.

Progressive joint pain and stiffness: The accumulation of HGA in cartilage leads to early-onset osteoarthritis, making movement increasingly difficult over time.

Skin and eye pigmentation changes: Affected individuals may develop bluish or grayish discoloration of the sclera (white part of the eye) and the skin, particularly in areas exposed to friction.

Cardiovascular and respiratory problems: With age, HGA accumulation can lead to valve calcifications in the heart and stiffening of connective tissues in the respiratory tract, which can cause problems in middle and old age.

Decreased mobility and spinal problems: The spine may become stiff and painful due to chronic cartilage degeneration.

These symptoms usually begin to manifest during adulthood, leading to severe complications in a person's 40s or 50s and significantly affecting the quality of their life.

How is Alkaptonuria Diagnosed?

Because of its rarity, alkaptonuria is often mistaken or overlooked early in life. However, there are several ways to confirm the condition:

Urine Testing: The gold standard in the diagnosis is the testing of urine samples for high levels of homogentisic acid via gas chromatography. In case of oxidation, which changes the color of urine to black, it is indicative of alkaptonuria.

Genetic Testing: Confirmatory genetic testing reveals mutations of the HGD gene to diagnose the condition conclusively.

Blood Tests: High levels of HGA in the blood can be used as further evidence.

Imaging Studies: X-rays and MRIs will expose cartilage and joint damage characteristic of alkaptonuria.

Management of Alkaptonuria: Is There A Cure?

At present, there is no cure for alkaptonuria; however, various treatment approaches can reduce its symptoms and slow the disease's progress:

Nitisinone Therapy: Nitisinone is a drug that inhibits the production of HGA. It has been shown to reduce HGA levels and slow tissue damage. However, it needs to be taken under close medical supervision because of potential side effects.

Low-Protein Diet: Since HGA is a byproduct of protein metabolism, reducing protein intake—especially foods rich in tyrosine and phenylalanine—may help decrease HGA production.

Pain Management: OTC pain relievers and anti-inflammatory medications can be used to relieve joint pain and stiffness.

Physical Therapy: Exercise regularly, as it may improve mobility and strengthen muscles, thus reducing strain on affected joints.

Surgical Interventions: Most people with alkaptonuria develop severe osteoarthritis necessitating joint replacement in their old age. Also, some may require heart valve replacement surgery if cardiovascular complications develop.

Life with Alkaptonuria

Although alkaptonuria is not fatal, it severely affects the quality of life. The progressive deterioration of the joints and associated symptoms can make everyday activities difficult, requiring lifestyle changes and medical interventions. The disease may cause premature aging of the joints, requiring walking aids and mobility assistance earlier than expected.

Ongoing research will continue to work on improving the treatment options by focusing on gene therapy and alternative enzyme replacement therapies. However, because of its rarity, the clinical trials and research remain sparse.

As genetic research advances, more hope for better management and possible curative approaches for alkaptonuria exists. Scientists are searching extensively for enzyme replacement therapies and innovative drugs that can target the root cause of the disorder. Being aware and being diagnosed early helps individuals better their condition and ultimately have better long-term health outcomes.

Alkaptonuria is a striking example of how one gene mutation can have widespread effects on the body. Though still a rare and often misunderstood condition, growing awareness and advances in treatment are paving the way for better care. If you or a loved one suspect symptoms of alkaptonuria, it is essential to seek early diagnosis and medical guidance to manage the disease effectively and preserve quality of life.

Many women may come across the term "breast density" following a mammogram, but not all of them fully understand what it implies. The fact that someone has dense breasts does not mean that they have cancer or that they will definitely get it.

On the other hand, greater breast density can be linked to a higher risk of breast cancer and may also make it more difficult to detect certain cancers on a mammogram.

What Is Breast Density?

The breast density is the ratio of fibrous and glandular tissue to fatty tissue in the breast. Dense breast tissue is a normal variation and is especially frequent in younger women. It should be clear that women cannot tell themselves if their breast has dense tissue or not; it has to be assessed using breast imaging, typically a mammogram.

Breast density is usually divided into four types, going from almost all fatty tissue to very dense tissue, and women who have heterogeneously dense or extremely dense breasts are at a greater risk of developing breast cancer than women whose breasts are mainly fatty.

Also read: Alcohol-Linked Cancer Deaths Doubled In US: Colorectal Leads In Men, Breast Leads In Women

What Do Dense Breasts Indicate?

A major concern is that on a mammogram dense tissue appears white, just as many breast abnormalities—some of which are cancers—do too. This makes it harder for radiologists to spot certain abnormalities. Women need not be alarmed if their mammogram report states that their breasts are dense.

Breast density is just one of the factors to take into account when evaluating the risk of breast cancer; family history, age, past breast conditions, genetic mutations, hormonal factors, reproductive history, and lifestyle must also be considered.

It will depend on a woman's total risk level whether or not further screening is needed. Although mammography is still an important method of screening, in certain individual cases a doctor may suggest extra imaging, for example breast ultrasound or magnetic resonance imaging (MRI). Such tests are not required automatically for every woman who has dense breasts.

Also read: How Scientists Blocked Drug-Resistant Triple-Negative Breast Cancer With A Two-Step Drug Method

What Should Women Do?

Women should also know what is normal for their breasts. If a new lump is detected, there is a persistent change in the shape or size of the breast, the skin becomes dimpled, the nipple turns inwards, there is an unusual discharge from the nipple or there is ongoing discomfort, then it is advisable to have a healthcare professional look at it. Yet the majority of breast changes are not cancerous and symptoms by themselves are not enough to make a diagnosis.

Lifestyle plays a big role in maintaining breast health. One way of reducing the overall risk of breast cancer is to keep a healthy weight, remain physically active, limit alcohol intake, avoid tobacco, eat a well-balanced diet and stick to the recommended screening programmes.

Women must not regard breast density as a diagnosis. The main point is that women should not be afraid of dense breasts but should understand what this means for them. They must talk to their family doctor about their mammography report and their individual risk factors and then follow a screening programme suitable to their risk.

Breast density is therefore a valid reason for having a screening examination, not one for concern. By understanding breast density and talking to a breast specialist, women can make informed choices regarding screening and make sure that any potential abnormalities are assessed as early as possible.

By Dr. Meghal Sanghavi, Consultant Onco Surgeon, Wockhardt Hospital, Mumbai Central

Teachers are unarguably one of the most important influences during the early stages of a person's life. Along with learning and wisdom, teachers can also influence a child's or adolescent's mental health. Thus, they help shape students who are the future of any society or nation. This impactful profession and its contributions are celebrated worldwide, including in India.

The deteriorating mental health condition in students has escalated into a major global public health concern, heavily accelerated by academic pressure, systemic changes, and digital isolation. The World Health Organization (WHO), UNICEF, and Indian governmental bodies like NCERT have shared data that reveals a grim situation: there is a huge gap between the rising psychological distress among youth and the infrastructure available to support them.

The role of teachers in youth mental health is a topic that the study "A Shelter for the Heart: The Impact of Teacher Quality on Students' Mental Health" has thoroughly analyzed. The research, published in the journal Health Economics in 2026, was conducted in China and included 3,529 Grade 7 students, 86 classrooms, and 43 schools throughout the country. The study examines the impact of teacher quality, proxied by teacher experience, on student mental health.

How Do Teachers Protect Students' Mental Health?

According to the study, the role of the head teacher is particularly important to a student's mental well-being. While subject teachers are primarily responsible for learning, the study emphasizes that experienced teachers might do more than improve grades—they may also help protect students' mental health.

The study finds that the more experienced head teachers tended to build stronger teacher–student relationships, communicate more with parents, and create more supportive classroom environments. They were less likely to ignore or isolate struggling students and more likely to try to help them. All in all, the researchers concluded that school environments play an important role in determining adolescents’ mental health.

Mental Health On Location And Gender

The study “A study on mental health of students teacher in relation to their achievement in education psychology” by researchers at Tamil Nadu Teachers Education University, Chennai, found significant differences in mental health based on gender and location, with female and rural student-teachers reporting better mental health than their male and urban counterparts.

Teacher Distress Linked To Student Mental Health

A 2024 study published in BMC Psychology by researchers from McMaster University, the University of Sydney, the University of Johannesburg and the Hospital for Sick Children examined the relationship between teacher distress and student mental health. The researchers analysed data from 23,568 students and 1,478 teachers across 268 schools in Ontario, Canada. The researchers suggested that supporting teachers’ mental health and creating safer school environments could also benefit students’ well-being.

A 2019 study published in the Journal of Affective Disorders by researchers led by Stephen Harding also suggested that better teacher well-being was associated with better student well-being, highlighting the potential importance of supporting teachers’ mental health within schools.

Teachers Day 2026

Teachers’ Day 2026 in India is celebrated on September 5 to honour the contribution of teachers and educators. The day marks the birth anniversary of Dr. Sarvepalli Radhakrishnan, India’s first Vice President and second President, who was a distinguished philosopher, scholar and teacher. Since 1962, his birthday has been observed as Teachers’ Day in India. The occasion recognises teachers’ role in shaping students’ knowledge, character, confidence and well-being, while inspiring future generations to learn, grow and contribute to society.

Deceased organ donation covers our organ needs. In India, we are woefully short of organs such as kidneys and livers in cases of liver and kidney failure that need to be transplanted.

Deceased donation, as the name sounds, is a donation by people who are brain dead, whose family has now accepted and has willingly donated their organs for the benefit of the rest of the world.

Live donation, on the other hand, is a donation by living or emotionally related individuals who want to donate a kidney to a diseased patient. A live donation is usually transplanted immediately. It's done in the same centre, and both are done together, as the harvesting of the organ from the donor and transplantation are done simultaneously.

On the other hand, a deceased organ from a cadaveric donor may be harvested in a different geographical location and may be transported over time and over a lot of distance to another centre.

Deceased donation can be done for organs that cannot be transplanted by live donation, which are so consequential to a human body, such as the heart, lungs, and pancreas. They are very vital and cannot be transplanted from a live patient to another.

In a deceased organ donation, we can even donate tissues such as the cornea, skin, and blood vessels, which are required as a part of donation, as a part of other organ donation transplant programmes or, for example, in giving vision to people who have a white cornea or corneal opacity.

These are a few differences between live and deceased or cadaveric donation.

Dr. Vikram Shah Batra, Director - Urology, Kidney Transplant and Uro Oncology, Max Super Speciality Hospital, Dwarka