Drug abuse is a serious problem, which is capable of not only causing death to the one using it, but create a havoc in the lives of those who are associated with that person too. There have been plenty cases, whether it is Matthew Perry or the recent death of Liam Payne, which is in trial currently.

It is also a problem in the US and is emerging as one of the health concerns that could destroy families and society. One of the most alarming aspects of drug abuse is also its impact on public safety as well as increased crime rates. Drugs also take a heavy toll on healthcare systems as emergency departments frequently encounter cases of drug overdoses, which puts the burden on medical professional who have the strain the limited resources available.

There are also long-term health impact due to drug abuse, which includes organ damage, infectious disease, mental health disorders and rise in healthcare cost.

Are there any specific drugs which are most abused in US?

Yes. There are commonly used drugs, which also includes prescribed painkillers like oxycodone, hydrocodone, and fentanyl, as well as illicit substances like heroin. As per recent data, opioid abuse has also reached alarming levels which has affected millions of Americans.

Here are the most abused drugs in the US:

Stimulants

They are used to increase alertness, attention, and energy. They also have a high potential for abuse due to the euphoric and performance enhancing effects. Cocaine and methamphetamine are notable stimulants frequently abused in the US. As per 2019 data, 10.3 million people reported to misuse stimulants in the previous year.

Depressants

These substances are used to slow down brain activity and induce relaxation. Benzodiazepines is one of the commonly prescribed medicine. Around 4.8 million individuals in the US have misused this drug.

Other misused drugs and its affects on the health:

Opioids:

It could lead to slow breathing and heart rate. It can also increase the risk of overdose and respiratory failure, constipation and a weakened immune system.

Stimulants:

It can elevate heart rate and blood pressure. It could also increase body temperate and lead to an irregular heartbeat. Furthermore, one can experience loss of appetite and weight loss.

Cannabis:

This can alter perception and coordination. People who consume it often have red eyes and a dry mouth. This can increase appetite, sometimes the "munchies" can reach to a point of no return and it could impair memory and cognitive function.

Benzodiazepines:

It could lead to sedation and drowsiness and an impaired coordination and balance. There also could be memory problems and confusion, along with respiratory depression, when combined with other depressant substance.

Alcohol:

This could lead to slurred speech, impaired condition, poor judgment and decision-making, liver damage and cirrhosis and an increased risk of accidents and injuries, which is the 3rd most leading cause of death in the US.

Additional Negative Impact: Social and psychological

Substance abuse impairs job performance and reliability, leading to frequent absenteeism, reduced productivity, and even job loss. This further leads to financial instability, strained relationships, and a cycle of dependency.

Worldwide, more than 57 million people live with dementia, experiencing symptoms such as short-term memory loss, difficulty finding words, confusion about time or place, trouble with complex tasks, and changes in mood or personality. Around 10 million new cases are diagnosed every year.

Recent studies suggest that the average lifetime risk of developing dementia after age 55 is about 42%.

A new study has found that maintaining healthy blood pressure, controlling blood sugar, and avoiding smoking during middle age could significantly reduce the risk of developing dementia.

People who maintained these three health measures between the ages of 48 and 68 lived, on average, nearly 13 additional years without dementia, according to the study published in the journal Neurology Open Access.

"Our findings argue that people need to actively avert these factors in midlife as a strategy for preserving brain health for more than a decade," said study senior investigator Josef Coresh, Professor in the Department of Population Health at NYU Langone.

"Discovering new ways to delay dementia is crucial with 42% of Americans at risk for developing the condition at any time after age 55," he added.

How Was the Study Conducted?

Researchers analyzed data from the Atherosclerosis Risk in Communities (ARIC) Study, an ongoing community-based study that began in 1986. It has tracked participants for decades, measuring midlife vascular risk factors and the development of dementia.

The analysis included 12,409 adults with an average age of 56, all of whom were free of dementia at the start of the study. Researchers assessed three key risk factors:

• High blood pressure
• Diabetes
• Smoking

• 3,008 people developed dementia.
• 5,238 died without developing dementia.

Key Findings

Researchers also examined how midlife cardiovascular risk factors affected dementia-free survival across different demographic groups.

Among participants with all three risk factors:

• Women lived an average of 18.1 years without developing dementia, compared with 16.6 years for men.
• White participants lived an average of 19.6 years without dementia, compared with 16.0 years for Black participants.

"Hopefully, these results will encourage people to stop smoking and watch their vascular health closely from age 48 on."

What Is Dementia?

Dementia is an umbrella term for a significant decline in mental function that interferes with daily life. It commonly affects memory, thinking, and reasoning abilities and is caused by underlying conditions such as Alzheimer's disease or vascular dementia.

While there is currently no cure, the WHO says up to 45 per cent of dementia risk can be prevented or delayed by addressing modifiable risk factors such as tobacco and alcohol use, physical inactivity, social isolation, air pollution, and noncommunicable diseases (NCDs), including high blood pressure and diabetes.

Through the first quarter of the twenty-first century, it has been clear that the global menace of infectious diseases has become very different in terms of their causal factors and predictability.

A 2022 review in Nature Reviews Microbiology by Princeton professors Rachel Baker and Jessica Metcalf aptly pointed out how climate change, urbanization, and wider travel and trade determine when, where, and how outbreaks of infections happen. Examples of such outbreaks are numerous globally, viz. SARS, H1N1, MERS, Ebola, Zika, and COVID-19 outbreaks. It has also been realized by biomedical scientists that more than half of all known pathogenic diseases have at some point been worsened by climate-change-related events.

As a result, research on climate-disease links has surged since the recent pandemic.

Evidence supporting this climate-disease relationship is also abundant in the Indian context. A major example is our experience with dengue infections, which are clearly losing their seasonal predictability. Contrary to its usual temporal link with the monsoon, India has encountered an unusually early transmission in 2026, with nearly 7,000 cases reported by end-February, as per the National Center for Vector-Borne Diseases Control data. The vector has also expanded its geographical distribution, for example into Himalayan towns such as Darjeeling over the past decade.

Meanwhile, the Integrated Disease Surveillance Program in India also reports bimodal waves of influenza transmission and infections with respiratory syncytial virus (RSV) surge during the monsoon. These provide evidence that overlapping and compressed disease seasons are becoming more common.

Warming temperatures and erratic rainfall alter mosquito breeding cycles and pathogen incubation periods, while floods can create sudden transmission spikes in a population. On the other hand, rapid urbanization increases overlap among human, animal, and vector habitats. India is expected to have an urban population of close to 600 million by 2031. This will further intensify livestock density, land-use change, and human-wildlife contact, raising the risk of zoonotic spillovers.

As is evident globally now, global travel and trade will carry the pathogens across borders way faster than health systems can respond. Thus, reactive outbreak responses, of testing, isolating, and reporting only after cases show a surge, are strategically too slow. However, genomic and wastewater surveillance offer scalable alternatives. For example, such efforts in India could detect SARS-CoV-2 variants in sewage much before case counts rose in a population.

Similar experience has been gathered in cities like Bengaluru, wherein wastewater monitoring could track influenza and RSV circulation independent of individual testing. Artificial intelligence and machine learning models further add to the forecasting capacity. Modelling climate, land-use, and animal-movement data can flag likely zoonotic spillover risks well before an outbreak begins.

India's national zoonotic disease prioritization exercise and state-level One Health pilot studies in Gujarat and Rajasthan show that human, veterinary, and environmental data must be integrated. Such interdisciplinary cohort research, tracking populations across seasons and geolocations, can achieve usable forecasts integrating discrete data. Thus, building such predictive, One Health-oriented research and surveillance infrastructure will be imperative for India to achieve optimal pandemic preparedness.

It has been long suspected that Western diets could contribute to the risk of colorectal cancer. The theory may finally have a clearer scientific explanation.

A new study suggests that gut bacteria can convert compounds produced by high-fat, low-fibre diets into cancer-causing chemicals. The research sheds light on how unhealthy eating habits may lead to cancerous tumour growth in colon in the long term.

What Did The Study Find?

Published in the journal Gut, the research was led by Dr. Annika Osswald (first author) and Dr. Soeren Ocvirk (corresponding author), along with a large team of international scientists.

The collaboration included researchers from Technical University of Munich (TUM), Germany, German Institute of Human Nutrition (DIfE), RWTH Aachen University, Freie Universität Berlin, University Hospital of Regensburg, and other institutions.

Researchers found that a western-style diet, which is commonly high in red and processed meat, saturated fats, refined carbohydrates and ultra-processed foods, significantly changes the composition of the gut microbiome.

These altered bacteria then modify bile acids in ways that promote inflammation and create an environment that accommodates the development of colorectal cancer tumours.

According to the researchers, diet alone is not the only factor. The trillions of microbes living in the intestine determine how food is processed, producing metabolites that can either protect the gut or damage it.

The study found that specific bacterial groups transformed bile acids into compounds that stimulated tumour growth in the colon.

This provides one of the strongestt explanations yet for why western dietary patterns have consistently been associated with higher risk of colorectal cancer.

"Our findings highlight the critical interaction between diet, gut microbes and cancer biology," the researchers noted, adding that targeting the microbiome could become a future strategy for preventing colorectal cancer.

Also read: Why English Actor Peter Duncan Is Advocating For Focal Therapy After His Prostate Cancer Treatment?

Negative Effects Of Western Diet

A western diet typically includes:

• High amounts of processed and red meat
• Fried foods and saturated fats
• Sugary drinks and desserts
• Refined grains
• Low intake of fruits, vegetables, legumes and whole grains

Previous research has repeatedly linked this eating pattern with obesity, diabetes, heart disease and colorectal cancer, but scientists have long found it challenging to explain the exact cause until now.

Also read: AI-Powered Blood Test Detects Liver Cancer Across Diverse Populations, Shows Promise In Earlier Diagnosis

Importance Of Gut Microbiome

The human gut is home to trillions of bacteria that help digest food, regulate immunity and produce beneficial compounds like fatty acids.

A fibre-rich diet supports good bacteria that reduce inflammation, whereas diets high in fat and processed foods can cause microbial imbalance.

The new findings suggest this imbalance changes how bile acids are metabolised, increasing the production of molecules capable of damaging the colon and supporting cancer growth in the long run.

Also read: WHO Cancer Agency Flags 3 Common Medicines As Carcinogenic: What It Means For Millions Of Patients

Colorectal Cancer Is Rising Among Younger Adults

Earlier research has linked harmful gut bacteria, including toxin-producing E. coli, with DNA damage that may begin early in life and contribute to the rise of colorectal cancer among younger people.

However, the latest findings do not prove diet alone causes cancer. Genetics, obesity, physical inactivity, sedentary life, smoking and alcohol consumption also influence risk.

However, they say maintaining a fibre-rich diet with fruits, vegetables, legumes and whole grains may help preserve a healthier gut microbiome and lower long-term colorectal cancer risk.