Drug abuse is a serious problem, which is capable of not only causing death to the one using it, but create a havoc in the lives of those who are associated with that person too. There have been plenty cases, whether it is Matthew Perry or the recent death of Liam Payne, which is in trial currently.

It is also a problem in the US and is emerging as one of the health concerns that could destroy families and society. One of the most alarming aspects of drug abuse is also its impact on public safety as well as increased crime rates. Drugs also take a heavy toll on healthcare systems as emergency departments frequently encounter cases of drug overdoses, which puts the burden on medical professional who have the strain the limited resources available.

There are also long-term health impact due to drug abuse, which includes organ damage, infectious disease, mental health disorders and rise in healthcare cost.

Are there any specific drugs which are most abused in US?

Yes. There are commonly used drugs, which also includes prescribed painkillers like oxycodone, hydrocodone, and fentanyl, as well as illicit substances like heroin. As per recent data, opioid abuse has also reached alarming levels which has affected millions of Americans.

Here are the most abused drugs in the US:

Stimulants

They are used to increase alertness, attention, and energy. They also have a high potential for abuse due to the euphoric and performance enhancing effects. Cocaine and methamphetamine are notable stimulants frequently abused in the US. As per 2019 data, 10.3 million people reported to misuse stimulants in the previous year.

Depressants

These substances are used to slow down brain activity and induce relaxation. Benzodiazepines is one of the commonly prescribed medicine. Around 4.8 million individuals in the US have misused this drug.

Other misused drugs and its affects on the health:

Opioids:

It could lead to slow breathing and heart rate. It can also increase the risk of overdose and respiratory failure, constipation and a weakened immune system.

Stimulants:

It can elevate heart rate and blood pressure. It could also increase body temperate and lead to an irregular heartbeat. Furthermore, one can experience loss of appetite and weight loss.

Cannabis:

This can alter perception and coordination. People who consume it often have red eyes and a dry mouth. This can increase appetite, sometimes the "munchies" can reach to a point of no return and it could impair memory and cognitive function.

Benzodiazepines:

It could lead to sedation and drowsiness and an impaired coordination and balance. There also could be memory problems and confusion, along with respiratory depression, when combined with other depressant substance.

Alcohol:

This could lead to slurred speech, impaired condition, poor judgment and decision-making, liver damage and cirrhosis and an increased risk of accidents and injuries, which is the 3rd most leading cause of death in the US.

Additional Negative Impact: Social and psychological

Substance abuse impairs job performance and reliability, leading to frequent absenteeism, reduced productivity, and even job loss. This further leads to financial instability, strained relationships, and a cycle of dependency.

Researchers have recently found that looking closely at the shape of the main buttock muscle, called the gluteus maximus, gives important clues about a person's health. This muscle shape reflects key changes linked to how we age, our lifestyle choices, and medical problems like diabetes.

This new study, done by a team at the University of Westminster, is unique because, unlike older research that only measured how big the muscle was, the team used advanced 3D mapping to show exactly where and how the muscle shape was changing.

These shifts, either the muscle shrinking (atrophy) or becoming inflamed, are connected to things like being frail, the amount of time someone sits each day, fat storage and diabetes risk.

How Do Muscle Changes Indicate Diabetes Risk?

the research analysed a large dataset, looking at over 61,000 MRI scans taken from the large U.K. Biobank health database.

Along with the MRI images, the dataset also included detailed information on 86 different factors for each person, including their medical history, body measurements, and what kind of lifestyle they led.

By putting all this data together, the team was able to figure out which specific factors were strongly linked to changes in the shape of the buttock muscle over time.

The analysis revealed strong connections between muscle shape and certain health factors:

Fitness

People who were considered fitter, meaning they reported doing more vigorous physical activity and had a stronger hand grip, tended to have a greater gluteus maximus shape. This often means the muscle was larger and more defined.

Aging and Frailty

On the other hand, factors like getting older, being generally frail (weak), and spending many hours sitting were all linked to muscle thinning or shrinkage. This suggests that a lack of use and the natural process of aging reduce the muscle's size and fullness.

How Gender Affects Muscle Responses

A very important discovery was that the gluteal muscles don't change in the same way for men and women, especially when they are dealing with a disease. For example, men who were considered frail showed more shrinkage (thinning) in their gluteus maximus compared to women who were also frail.

When the researchers examined Type 2 diabetes, the difference was even more noticeable: diabetic men showed clear muscle thinning (reduced muscle mass), while diabetic women often showed enlarged muscle mass.

This larger appearance in women is likely due to fat building up within the muscle tissue, rather than the muscle itself growing stronger. These differences strongly suggest that the body's biological response to diseases like Type 2 diabetes may be completely different between men and women.

What Does Your Glute Shape Reveal About Health??

The researchers conclude that the shape of the buttocks, rather than simply its size, is more closely connected to fundamental metabolic changes happening in the body. Because the gluteus maximus is one of the largest muscles in the body, its health plays a crucial role in overall metabolic health.

These findings suggest that tracking gluteal muscle shape could potentially become a new way to monitor metabolic health and disease risk.

The NHS will not be automatically inviting all men above a certain age to check for prostate cancer, unlike the approach for some other cancers. The UK National Screening Committee has suggested that the prostate-specific antigen (PSA) test should only be actively offered to men carrying the BRCA gene mutation, which increases their risk. Still, men can request a PSA test from their GP in certain situations.

Olympic cycling hero Sir Chris Hoy, who has received a terminal diagnosis, is among those campaigning for men with known risk factors to be invited for a PSA test at a certain age, even if they do not have any symptoms.

Prostate Cancer Screening: What Is The PSA Test?

A prostate-specific antigen (PSA) test checks the level of PSA in your blood. PSA is a protein produced by the prostate, a small gland in the male reproductive system located just below the bladder. The prostate produces the fluid part of semen.

The NHS says the test might be suggested if you notice symptoms that could point to prostate cancer, such as:

• urinating more often than usual, feeling a sudden urge to pee, or waking up frequently at night to urinate
• blood in your urine
• difficulty getting or maintaining an erection

However, for most men, urinary symptoms are caused by something other than cancer.

A PSA test is usually carried out at a hospital or GP surgery by a nurse or other healthcare professional. Men are asked to avoid certain activities for 48 hours before the test, as these can temporarily raise PSA levels and affect the result. Activities to avoid include anything that leaves you out of breath, like strenuous exercise.

If a man’s PSA level comes back high, they may be offered a repeat test to see if the levels remain raised. If they do, the GP may refer them to a specialist for further investigations, such as a biopsy or an MRI scan.

Prostate Cancer Screening: Why Is The PSA Screening So Controversial?

PSA levels can rise for many reasons, including minor infections, and around 75% of men with a raised PSA do not have prostate cancer. A high reading can lead to referrals for unnecessary biopsies or MRI scans, or treatment for tumours that might never have caused harm.

The PSA test can also miss aggressive cancers. Research has shown that roughly 15% of men with a normal PSA result may actually have prostate cancer.

Prostate Cancer Screening: Who Can Currently Get The PSA Test?

Routine PSA testing is not offered as standard on the NHS. You might be offered a test if a doctor suspects symptoms that could indicate prostate cancer. Men undergoing treatment for a prostate condition may be offered regular PSA checks to monitor how treatment is progressing.

Men aged 50 and over can request a PSA test from their GP, even without symptoms. Campaigners say many men are unaware that they are at higher risk of prostate cancer and should be actively encouraged to think about having a PSA check.

Prostate Cancer Screening: Who Else Could Get It?

If the UK National Screening Committee’s recommendation is approved by the Government next year, men with the BRCA gene mutation could also be invited for a PSA test. Men who think a family member might have had the BRCA gene mutation can request a genetic test on the NHS to find out.

Alzheimer's disease is the most common cause of dementia. As you may know, It is a physical illness that causes the brain to gradually stop functioning correctly, leading to a decline in memory and thinking skills. Alzheimer’s is not just a condition that affects not only memory but also many aspects of daily life, including behavior patterns, routines, and speech.

According to Alzheimer’s Society, the disease is affecting more people than ever: roughly one million people in the UK currently have dementia, a figure expected to rise significantly by 2050.

Catching Alzheimer's early is key to ensuring patients and caregivers receive the right medical care and support. One of the best ways to spot the beginning of mental decline is by noticing changes in how a person uses language and speaks.

5 Speech Clues That May Signal Early Alzheimer's

New speech problems are often one of the first indicators of the disease. Here are five subtle signs to watch out for:

Pauses, Hesitations, and Vagueness

People often have trouble finding the exact word they want to use. This causes them to stop frequently, leading to long pauses and hesitations while speaking. When they can't remember the word, they might use very general words like "thing," or they will try to describe what the forgotten word is, they will describe the forgotten word instead of saying it directly.

Using Incorrect but Related Words

A person might replace the correct word with one that is somehow connected to it. For instance, if they mean to say "fork," they might mistakenly say "spoon" because both are common eating tools. In the very early stages, they might use a general category word, like saying "animal" instead of the specific word, "cat."

Talking About a Task Instead of Doing It

When someone needs to start a task, they may struggle to begin or complete it. Instead of discussing the actual steps needed, they talk about their feelings. They might say, "I used to be able to do this easily," or "I don't think I can manage it now," showing worry or doubt instead of focusing on the job at hand.

Less Word Variety

The person's language starts to sound much simpler and less colourful. They tend to stick to basic, common words and may repeat the same verbs and adjectives over and over again. They also use connecting words like "the," "and," or "but" very often to link their basic sentences, making their speech sound repetitive.

Trouble Finding Words in Groups (Categorization)

It becomes difficult for them to quickly name things that belong to a specific category. For example, if asked to name five types of food, different parts of the body, or words starting with the letter 'P,' they struggle. This challenge becomes noticeably harder and more frustrating as the disease progresses.

Why Early Detection Matters

While everyone forgets a word now and then, Persistent and worsening problems with memory, fluency, and varied language could be an early sign of Alzheimer's.

Age is the biggest factor for Alzheimer's risk, with the chance doubling every five years after age 65. However, the disease can affect people under 65 (early-onset Alzheimer's). Spotting these speech changes early is especially crucial for people who are already at a higher risk, such as those with Down Syndrome.