Drug abuse is a serious problem, which is capable of not only causing death to the one using it, but create a havoc in the lives of those who are associated with that person too. There have been plenty cases, whether it is Matthew Perry or the recent death of Liam Payne, which is in trial currently.

It is also a problem in the US and is emerging as one of the health concerns that could destroy families and society. One of the most alarming aspects of drug abuse is also its impact on public safety as well as increased crime rates. Drugs also take a heavy toll on healthcare systems as emergency departments frequently encounter cases of drug overdoses, which puts the burden on medical professional who have the strain the limited resources available.

There are also long-term health impact due to drug abuse, which includes organ damage, infectious disease, mental health disorders and rise in healthcare cost.

Are there any specific drugs which are most abused in US?

Yes. There are commonly used drugs, which also includes prescribed painkillers like oxycodone, hydrocodone, and fentanyl, as well as illicit substances like heroin. As per recent data, opioid abuse has also reached alarming levels which has affected millions of Americans.

Here are the most abused drugs in the US:

Stimulants

They are used to increase alertness, attention, and energy. They also have a high potential for abuse due to the euphoric and performance enhancing effects. Cocaine and methamphetamine are notable stimulants frequently abused in the US. As per 2019 data, 10.3 million people reported to misuse stimulants in the previous year.

Depressants

These substances are used to slow down brain activity and induce relaxation. Benzodiazepines is one of the commonly prescribed medicine. Around 4.8 million individuals in the US have misused this drug.

Other misused drugs and its affects on the health:

Opioids:

It could lead to slow breathing and heart rate. It can also increase the risk of overdose and respiratory failure, constipation and a weakened immune system.

Stimulants:

It can elevate heart rate and blood pressure. It could also increase body temperate and lead to an irregular heartbeat. Furthermore, one can experience loss of appetite and weight loss.

Cannabis:

This can alter perception and coordination. People who consume it often have red eyes and a dry mouth. This can increase appetite, sometimes the "munchies" can reach to a point of no return and it could impair memory and cognitive function.

Benzodiazepines:

It could lead to sedation and drowsiness and an impaired coordination and balance. There also could be memory problems and confusion, along with respiratory depression, when combined with other depressant substance.

Alcohol:

This could lead to slurred speech, impaired condition, poor judgment and decision-making, liver damage and cirrhosis and an increased risk of accidents and injuries, which is the 3rd most leading cause of death in the US.

Additional Negative Impact: Social and psychological

Substance abuse impairs job performance and reliability, leading to frequent absenteeism, reduced productivity, and even job loss. This further leads to financial instability, strained relationships, and a cycle of dependency.

The brain is a crucial component of the human body. It is an integral part of the whole system, but when the body ages, the brain does too. The brain is the organ that plays a big role in the aging process. The brain protein is an important component of the body, and can positively impact inflammation, memory decline, and other age-related changes.

A recent study conducted by PLOS Biology claims that the brain protein Menin loss can be crucial to inflammation, memory decline, and other age-related changes. The researchers in the study used mice as test subjects and tried to restore the very protein in them, which worked marvelously; aging conditions were completely reversed.

The study found that aging can be highly influenced by the hypothalamus, a strong brain region that regulates metabolism, hormones, body temperature, sleep, and stress responses. According to the researchers, the hypothalamus is a central command centre for aging.

The research was done by Lige Leng and colleagues at Xiamen University in China and mainly focused on the Menin. They intended to see what the impact would be if someone lost this very important protective protein. The study on mice shows that when Menin levels drop in the hypothalamus, it causes faster aging.

The study specifically used young mice and reduced menin levels; as a result, they faced brain inflammation, thinning skin, lower bone mass, impaired balance, memory problems, and a shorter lifespan. Thus, the conclusion of the research was that menin is likely to act as an anti-aging component in the body.

How Much Protein Do You Really Need?

Your protein needs aren’t one-size-fits-all. They depend on several factors: your weight, age, physical activity, body composition goals, and overall health status.

The Recommended Dietary Allowance (RDA) for the average adult is 0.36 grams per pound (0.8 grams per kilogram) of body weight. This amount is to meet basic nutritional needs in most sedentary adults.

However, experts suggest that physically active people often need more, anywhere from 0.54 to 0.9 grams per pound (1.2–2 grams per kilogram) per day. Athletes may even require higher amounts to support muscle repair and performance.

Certain groups, such as pregnant or breastfeeding individuals, older adults, and people recovering from illness or injury, also have increased protein needs. For example, during pregnancy, the recommendation rises to about 0.5 grams per pound (1.1 grams per kilogram).

According to the World Health Organization (WHO), tobacco use kills over 8 million people globally each year, including non-smokers exposed to second-hand smoke.

India continues to face a massive burden of tobacco addiction. Cigarettes, bidis, gutka, pan masala and khaini continue to affect millions, including young adults. This year’s WHO theme- “Unmasking the Appeal: Countering Nicotine and Tobacco Addiction” focuses on how flavoured products, attractive packaging and social media marketing are making nicotine products appealing to the younger generation.

Tobacco damages nearly every organ in the body. It is strongly linked to cancers of the mouth, throat, voice box, lungs, food pipe and bladder. In India, oral cancer remains one of the commonest cancers, largely driven by smokeless tobacco use. Tobacco also increases the risk of heart attacks, strokes, chronic lung disease, infertility and poor immunity.

Many people mistakenly believe that e-cigarettes and vaping are “safe alternatives.” However, e-cigarettes still contain addictive nicotine and harmful chemicals that can damage the lungs and cardiovascular system. They may also act as a gateway to conventional tobacco use among teenagers and young adults. Recognising these risks, India banned the production, sale and advertisement of e-cigarettes under the Prohibition of Electronic Cigarettes Act, 2019.

The encouraging fact is that quitting works at any age. Within weeks of stopping tobacco, blood pressure and lung function begin to improve, while long-term risks of cancer and heart disease reduce significantly.

Simple Steps To Quit Tobacco

* Fix a quit date and inform family and friends.

* Identify triggers such as stress, tea, alcohol or social gatherings.

* Avoid keeping tobacco products nearby.

* Stay physically active and hydrated.

* Seek professional counselling if cravings are severe.

* Nicotine replacement therapy or prescribed medications may help selected individuals.

* Remember that relapses can happen and restarting the quit journey is still progress.

World No Tobacco Day is not just about awareness but is a call to action. Choosing to quit today may be the single most important decision for a healthier and longer life.

(Dr Akshat Malik, Senior Consultant, Head & Neck Oncology, Apollo Hospital, Delhi)

According to the Indian Council of Medical Research - National Cancer Registry Programme (ICMR-NCRP), India reports about 220,000 new cases every year, and the common treatment procedure for this disease is chemotherapy, which comes with profound fatigue, hair loss, nausea, compromised immunity, and nerve damage.

The University College London led the Optima trial, which studied over 4000 patients with the disease in different parts of the world, and a low score on the genomic test could be mediated with only hormone therapy.

The trial’s chief investigator and a professor of breast oncology at UCL, Professor Rob Stein, explains that the study used tumour biology to guide decisions instead of relying on traditional clinical procedures.

The research had 4,429 women participants above the age of 40 years with hormone-positive breast cancer. These patients were then divided into two groups based on the genomic test results by the researchers, and one group with a higher risk was given chemotherapy along with hormone therapy, while the others were only treated with hormone therapy.

What Is Breast Cancer?

Breast cancer refers to the uncontrolled growth of the cells that are found along the inner lining of breast tissue. This out-of-control growth of cells leads to the formation of tumours. The tumour can be “invasive”, meaning that it spreads to the nearby tissues outside the breast, or “in situ”, where the tumour does not spread outside the breast region.

Usually, the “in situ” type of tumour is non-cancerous and non-life-threatening. However, in the case of invasive tumours, the cancerous cell mass can spread to the lymph nodes and further metastasise, that is, spread to other body parts. About 80% times the breast cancer cases are invasive. Hence, upon noticing symptoms like lumps, changes in breast shape, or abnormal nipple discharge, you must promptly consult a doctor.

While both men and women can develop it, in 99% of cases of breast cancer, women are seen to be affected by it. Only 0.5 to 1% of men are affected due to this condition. Furthermore, the condition is mostly prevalent in women aged 50 or older.