Drug abuse is a serious problem, which is capable of not only causing death to the one using it, but create a havoc in the lives of those who are associated with that person too. There have been plenty cases, whether it is Matthew Perry or the recent death of Liam Payne, which is in trial currently.

It is also a problem in the US and is emerging as one of the health concerns that could destroy families and society. One of the most alarming aspects of drug abuse is also its impact on public safety as well as increased crime rates. Drugs also take a heavy toll on healthcare systems as emergency departments frequently encounter cases of drug overdoses, which puts the burden on medical professional who have the strain the limited resources available.

There are also long-term health impact due to drug abuse, which includes organ damage, infectious disease, mental health disorders and rise in healthcare cost.

Are there any specific drugs which are most abused in US?

Yes. There are commonly used drugs, which also includes prescribed painkillers like oxycodone, hydrocodone, and fentanyl, as well as illicit substances like heroin. As per recent data, opioid abuse has also reached alarming levels which has affected millions of Americans.

Here are the most abused drugs in the US:

Stimulants

They are used to increase alertness, attention, and energy. They also have a high potential for abuse due to the euphoric and performance enhancing effects. Cocaine and methamphetamine are notable stimulants frequently abused in the US. As per 2019 data, 10.3 million people reported to misuse stimulants in the previous year.

Depressants

These substances are used to slow down brain activity and induce relaxation. Benzodiazepines is one of the commonly prescribed medicine. Around 4.8 million individuals in the US have misused this drug.

Other misused drugs and its affects on the health:

Opioids:

It could lead to slow breathing and heart rate. It can also increase the risk of overdose and respiratory failure, constipation and a weakened immune system.

Stimulants:

It can elevate heart rate and blood pressure. It could also increase body temperate and lead to an irregular heartbeat. Furthermore, one can experience loss of appetite and weight loss.

Cannabis:

This can alter perception and coordination. People who consume it often have red eyes and a dry mouth. This can increase appetite, sometimes the "munchies" can reach to a point of no return and it could impair memory and cognitive function.

Benzodiazepines:

It could lead to sedation and drowsiness and an impaired coordination and balance. There also could be memory problems and confusion, along with respiratory depression, when combined with other depressant substance.

Alcohol:

This could lead to slurred speech, impaired condition, poor judgment and decision-making, liver damage and cirrhosis and an increased risk of accidents and injuries, which is the 3rd most leading cause of death in the US.

Additional Negative Impact: Social and psychological

Substance abuse impairs job performance and reliability, leading to frequent absenteeism, reduced productivity, and even job loss. This further leads to financial instability, strained relationships, and a cycle of dependency.

A Doppler test is a specialized type of ultrasound that uses sound waves to measure blood flow through blood vessels rather than simply creating images of organs and tissues. Unlike a regular ultrasound, which produces pictures of internal structures, a Doppler ultrasound shows how blood moves through arteries and veins, helping doctors detect circulation problems.

While commonly associated with pregnancy, Doppler ultrasound is also used to investigate conditions such as leg pain, swelling, varicose veins, blood clots, peripheral artery disease, and stroke risk. Understanding when this test is needed can help detect serious conditions early and guide timely treatment.

Why Is Doppler Ultrasound Important During Pregnancy?

During pregnancy, a Doppler ultrasound is often recommended in high-risk cases to assess blood flow between the mother, placenta, and baby.

"It helps doctors monitor whether the fetus is receiving adequate oxygen and nutrients, making it especially important in pregnancies complicated by high blood pressure, diabetes, fetal growth restriction, or previous pregnancy-related complications," Dr. Vandana Mittal, Principal Consultant, Obstetrics and Gynecology, Paras Health Panchkula, told HealthandMe.

Dr. Vandana Jain, Principal Consultant - Obstetrics, Gynecology, Infertility & Advanced Laparoscopic Surgery, Yashoda Medicity, added that the test is commonly recommended in high-risk pregnancies, including fetal growth restriction, preeclampsia, hypertension, gestational diabetes, oligohydramnios, multiple pregnancies, and decreased fetal movements.

"By evaluating how effectively oxygen and nutrients are reaching the baby, the test helps detect signs of fetal compromise at an early stage, enabling timely monitoring, appropriate medical intervention, and informed decisions regarding the timing and mode of delivery."

By identifying potential issues early, Doppler studies help doctors monitor pregnancies more closely and intervene when necessary. However, the test is performed only for specific medical indications and is not a replacement for routine pregnancy ultrasounds.

What Other Conditions Can a Doppler Ultrasound Detect?

According to the Mayo Clinic, a Doppler ultrasound can help diagnose:

• Blood clots
• Venous insufficiency, where poorly functioning vein valves cause blood or fluid to pool in the legs
• Heart valve defects and congenital heart disease
• Arterial occlusion (blocked arteries)
• Peripheral artery disease
• Aneurysms
• Carotid artery stenosis, which increases stroke risk

How Doppler Ultrasound Can Help People With Leg Pain

Dr. Jain said Doppler ultrasound is also commonly advised for patients with suspected Deep Vein Thrombosis (DVT), peripheral arterial disease, carotid artery narrowing, or chronic venous insufficiency.

"It is commonly advised for patients with suspected Deep Vein Thrombosis (DVT), peripheral arterial disease, carotid artery narrowing, or chronic venous insufficiency," she told HealthandMe.

The expert added that people with persistent leg pain while walking, unexplained swelling, non-healing wounds, or symptoms of poor circulation may require a Doppler evaluation.

Recently, gastroenterologist Dr. Pal Manickam highlighted the importance of Doppler ultrasound during a podcast discussion. He urged people not to ignore sudden leg pain or swelling, noting that these symptoms could indicate deep vein thrombosis (DVT) and require prompt evaluation.

How Is a Doppler Test Done?

The procedure is painless, non-invasive, and usually takes 30 to 60 minutes, depending on the area being examined. It is also radiation-free.

A Doppler ultrasound is performed by a trained sonographer using a hand-held device called a transducer. The transducer sends sound waves into the body and measures how they bounce off moving blood cells, allowing the machine to assess blood flow in real time.

For years, excess weight has been considered one of the biggest risk factors for fatty liver disease. However, doctors are now seeing a growing number of Indians being diagnosed with Grade-1 fatty liver despite having a normal or only slightly elevated body mass index (BMI).

The emerging pattern is challenging the long-held belief that only people with obesity are at risk. Ahead of the World Hepatitis Day, observed every year on July 28, the health experts said it highlights the need to look beyond the number on the weighing scale, as excess abdominal fat, insulin resistance, poor diet, sedentary lifestyles, and genetic predisposition are increasingly being linked to early liver damage.

Hidden Metabolic Problems, Not Just Obesity

Speaking to HealthandMe, Dr. Pankaj Sharma, Director of Dept. Robotics, Bariatric, Laparoscopic and General Surgery, Fortis Hospital, Shalimar Bagh, said the trend reflects the rise of hidden metabolic problems rather than visible obesity.

"Many Indians develop excess fat around internal organs even when their BMI is within the normal range. Sedentary lifestyles, processed foods, sugary drinks, poor sleep and insulin resistance all contribute to fat accumulation in the liver. Grade-1 fatty liver is often the body's first signal that metabolic health is beginning to suffer," he said.

The doctors highlighted that many Indians develop visceral fat despite having a normal BMI, making them vulnerable to metabolic disorders. This means a healthy weight alone does not always translate to a healthy liver.

Also read: 1 In 4 Diabetic Patients in India Suffer from Liver Fibrosis, Finds Lancet Study

Fatty Liver Can Affect Fertility Too

The effects of fatty liver may extend beyond liver health, said Dr. Shobha Gupta, Medical Director and Infertility Specialist at Mother's Lap IVF Centre, Pitampura, New Delhi. She noted that metabolic disorders are increasingly affecting fertility in younger adults.

"Fatty liver is often part of a larger metabolic imbalance. In women, it may coexist with insulin resistance and PCOS, affecting ovulation, while in men, poor metabolic health can compromise sperm quality. Improving metabolic fitness before conception can support both fertility and a healthier pregnancy," she told HealthandMe.

Doctors also recommend assessing liver and overall metabolic health early during fertility treatment.

Is the Condition Reversible?

The experts emphasized that Grade-1 fatty liver is one of the few lifestyle-related conditions that can often be reversed if detected early.

"Instead of waiting for symptoms, people should pay attention to routine health check-ups, stay physically active and make sustainable lifestyle changes. Prevention is always easier than treating advanced liver disease," Dr. Sharma said.

Doctors recommend regular exercise, a balanced diet, maintaining a healthy waistline, and controlling blood sugar and cholesterol to prevent further liver damage.

What Is Grade-1 Fatty Liver?

Read More: NAFLD to MASLD: Experts Explain Why This Common Yet Dangerous Liver Condition Got Renamed

Grade-1 fatty liver, also known as mild steatosis, is the earliest and usually reversible stage of fatty liver disease. In this stage, about 5-10% of the liver contains excess fat.

If left untreated, the disease can progress to liver fibrosis, where scar tissue gradually replaces healthy liver tissue due to chronic inflammation. Advanced fibrosis can eventually lead to irreversible liver damage (cirrhosis), increasing the risk of liver failure and liver cancer.

Grade-1 Fatty Liver: Key Symptoms

The doctors warned that liver disease often remains unnoticed until it has significantly progressed. But some people may experience:

• Fatigue
• Discomfort in the upper right abdomen
• High triglyceride levels
• Unexplained weight gain
• Impaired blood sugar control

Grade-1 Fatty Liver: How Is It Diagnosed?

Doctors may diagnose fatty liver using a combination of:

• Blood tests, including liver enzymes (ALT and AST)
• Lipid profile
• Blood sugar tests
• Ultrasound
• CT or MRI scan
• FibroScan.

For decades, fluoride has been the gold standard in oral care. It promotes remineralization, strengthens enamel, and has played a central role in reducing dental caries worldwide. But as oral care science advances, a question has emerged: can we do more?

Research suggests we can. One of the most promising developments in preventive oral care is the use of arginine, a naturally occurring amino acid, alongside fluoride. Together, they offer a dual-action approach that not only repairs weakened enamel but also helps create the optimal oral environment to prevent future damage.

To understand why this matters, it helps to look at how far oral care has come. For decades, the message was straightforward -- brush twice a day, use fluoride toothpaste, limit sugar. While that foundational advice still holds, the science of oral health has moved well beyond the basics. We now understand that dental care is not simply a matter of sugar and bacteria; it is a dynamic, multifactorial process driven by the interplay between acid-producing microorganisms, saliva, diet and the delicate balance between demineralization and remineralization on the tooth surface.

When pathological factors such as acidogenic bacteria and frequent sugar intake outweigh protective factors, enamel begins to weaken. This understanding has prompted researchers to explore ingredients that do not just protect teeth passively but actively support the mouth's natural defense mechanisms.

Arginine And Fluoride: How The Dual-action Approach Works

Arginine is a semi-essential amino acid found naturally in dietary proteins and in human saliva. In the oral cavity, it plays a unique and important role. It serves as fuel for beneficial bacteria that help keep the mouth's pH balanced.

Arginine acts like a prebiotic for the mouth, nourishing the good bacteria while making it harder for harmful ones to thrive. Research has shown that caries-free individuals tend to have significantly higher levels of arginine-metabolizing activity in their saliva and plaque compared to those with active cavities.

Fluoride and arginine work through distinct but highly complementary mechanisms. Fluoride promotes the uptake of calcium and phosphate into weakened enamel, forming a more acid-resistant mineral structure.

Arginine, on the other hand, addresses the root cause of enamel damage (the acidic environment created by cariogenic bacteria) by modulating plaque pH and supporting a healthier oral microbiome. When combined, these two ingredients offer a dual-action approach: fluoride repairs and strengthens the enamel surface, while arginine creates the favorable conditions that help sustain that repair over time.

Clinical evidence supports this synergy. A comparative in vitro study published in Cureus (2024) found that the combination of arginine with fluoride demonstrated superior remineralisation potential compared to established agents such as Bioactive Glass and CPP-ACP technology used individually. Similarly, research published in the Journal of Dental Research demonstrated that fluoride and arginine together synergistically suppressed Streptococcus mutans, a key caries-causing bacterium, while enriching health-associated species within dental biofilms.

A clinical study conducted by Cantore et al confirmed that toothpaste containing 1.5% arginine and 1000ppm fluoride significantly increased oral ammonia concentration, an indicator of active pH buffering. A study done by Fatima et al demonstrated the shift in the oral microbiome toward a healthier composition. In short, the arginine-fluoride combination works with the mouth’s chemistry and biology to give better Enamel remineralization than Fluoride alone.

However, while the evidence supporting this dual-action approach continues to grow, not all products reflect the same level of clinical validation.

Why Science-backed Formulations Matter?

In a market crowded with oral care products making various claims, consumers need to look beyond marketing language and understand the science behind what they use. Not all ingredient combinations are created equal, and not every claim is supported by rigorous clinical evidence.

The arginine-fluoride combination is backed by a substantial body of peer-reviewed research -- from laboratory studies and in situ models to randomized clinical trials. As a consensus report published in the International Journal of Clinical Pediatric Dentistry notes, several clinical studies using 1.5% arginine combined with fluoride3 have provided robust evidence for its use in preventing dental caries and supporting enamel health.

Choosing oral care products grounded in clinical evidence is not just a matter of efficacy; it is a matter of trust. When an ingredient's benefits are validated through independent, published research, consumers can make more informed choices about their oral health.

The Takeaway

Fluoride remains a cornerstone of oral care. But the science has moved forward, and so should our approach to strengthening teeth. Arginine represents a significant advance, not as a replacement for fluoride, but as a powerful complement that addresses oral health at both the chemical and microbial levels. By choosing formulations that combine arginine with fluoride, consumers can benefit from an approach that goes beyond surface-level protection, one that actively supports the mouth's natural ability to repair, strengthen and defend itself against decay.

As oral care continues to evolve, the future will be defined not by single-ingredient solutions, but by science-led formulations that work with the body’s natural biology. The combination of arginine and fluoride is a step in that direction.