People receiving weight-loss drug Wegovy sustained weight loss for up to four years, shedding an average of 10% of their body weight in that time, as per a new study. Wegrovy is a brand that markets semaglutide injections, that have gained widespread attention for their weight-loss effects. The study also found that Semaglutide injections boost an individual's heart health, even when weight loss doesn't take place.

The study, called SELECT, was published in journal Nature Medicine. "At four years, we see ongoing benefits of semaglutide," said Cheng-Han Chen, MD, interventional cardiologist from Cardiologist, who was not involved in the research. Besides the weight loss, it also lead to a loss in cardiovascular outcomes.

The research was conducted on 17000 adults, who had obesity but did not have diabetes. Overall, people who received once-weekly injections of semaglutide lost on average 10.2% of their body weight over the course of four years. All of the study participants continued to lose weight for about 65 weeks, a year and three months, and then their weight remained at a stable level.

Were There Any Side Effects?

What Did The Results Say?

Of the people on the highest dose of Wegovy, 68% lost at least 5% of their body weight. This compared to 21% of people on the placebo. Additionally, of the total people on Wegovy about 23% lost at least 15% of their body weight. For those in the placebo group, only 1.7% lost that much body weight.

Semaglutide Shows Heart Benefits Beyond Weight Loss

Researchers found that even individuals who did not experience significant weight reduction while on the drug saw a reduced risk of major heart events. Recent analysis of the SELECT trial data revealed that semaglutide significantly lowers the risk of heart attack, stroke, and cardiovascular-related deaths in adults with obesity or those who are overweight. Notably, the results of this study lead the US FDA to approve Novo Nordisk's Wegovy for reducing heart-related risks in this group.

What Is Semaglutide?

Are Their Any Side Effects Of Semaglutide?

Semaglutide, marketed under the brand name Wegovy, is primarily an antidiabetic medication used to treat Type 2 diabetes. It is also an anti-obesity drug used for long-term weight management. While it can be taken as a subcutaneous injection or orally, it has significant side effects. It primarily impacts your gastrointestinal tract and its side effects include constipation, nausea, abdominal pain, diarrhoea, and fatigue amongst others.

The brain is a crucial component of the human body. It is an integral part of the whole system, but when the body ages, the brain does too. The brain is the organ that plays a big role in the aging process. The brain protein is an important component of the body, and can positively impact inflammation, memory decline, and other age-related changes.

A recent study conducted by PLOS Biology claims that the brain protein Menin loss can be crucial to inflammation, memory decline, and other age-related changes. The researchers in the study used mice as test subjects and tried to restore the very protein in them, which worked marvelously; aging conditions were completely reversed.

The study found that aging can be highly influenced by the hypothalamus, a strong brain region that regulates metabolism, hormones, body temperature, sleep, and stress responses. According to the researchers, the hypothalamus is a central command centre for aging.

The research was done by Lige Leng and colleagues at Xiamen University in China and mainly focused on the Menin. They intended to see what the impact would be if someone lost this very important protective protein. The study on mice shows that when Menin levels drop in the hypothalamus, it causes faster aging.

The study specifically used young mice and reduced menin levels; as a result, they faced brain inflammation, thinning skin, lower bone mass, impaired balance, memory problems, and a shorter lifespan. Thus, the conclusion of the research was that menin is likely to act as an anti-aging component in the body.

How Much Protein Do You Really Need?

Your protein needs aren’t one-size-fits-all. They depend on several factors: your weight, age, physical activity, body composition goals, and overall health status.

The Recommended Dietary Allowance (RDA) for the average adult is 0.36 grams per pound (0.8 grams per kilogram) of body weight. This amount is to meet basic nutritional needs in most sedentary adults.

However, experts suggest that physically active people often need more, anywhere from 0.54 to 0.9 grams per pound (1.2–2 grams per kilogram) per day. Athletes may even require higher amounts to support muscle repair and performance.

Certain groups, such as pregnant or breastfeeding individuals, older adults, and people recovering from illness or injury, also have increased protein needs. For example, during pregnancy, the recommendation rises to about 0.5 grams per pound (1.1 grams per kilogram).

According to the World Health Organization (WHO), tobacco use kills over 8 million people globally each year, including non-smokers exposed to second-hand smoke.

India continues to face a massive burden of tobacco addiction. Cigarettes, bidis, gutka, pan masala and khaini continue to affect millions, including young adults. This year’s WHO theme- “Unmasking the Appeal: Countering Nicotine and Tobacco Addiction” focuses on how flavoured products, attractive packaging and social media marketing are making nicotine products appealing to the younger generation.

Tobacco damages nearly every organ in the body. It is strongly linked to cancers of the mouth, throat, voice box, lungs, food pipe and bladder. In India, oral cancer remains one of the commonest cancers, largely driven by smokeless tobacco use. Tobacco also increases the risk of heart attacks, strokes, chronic lung disease, infertility and poor immunity.

Many people mistakenly believe that e-cigarettes and vaping are “safe alternatives.” However, e-cigarettes still contain addictive nicotine and harmful chemicals that can damage the lungs and cardiovascular system. They may also act as a gateway to conventional tobacco use among teenagers and young adults. Recognising these risks, India banned the production, sale and advertisement of e-cigarettes under the Prohibition of Electronic Cigarettes Act, 2019.

The encouraging fact is that quitting works at any age. Within weeks of stopping tobacco, blood pressure and lung function begin to improve, while long-term risks of cancer and heart disease reduce significantly.

Simple Steps To Quit Tobacco

* Fix a quit date and inform family and friends.

* Identify triggers such as stress, tea, alcohol or social gatherings.

* Avoid keeping tobacco products nearby.

* Stay physically active and hydrated.

* Seek professional counselling if cravings are severe.

* Nicotine replacement therapy or prescribed medications may help selected individuals.

* Remember that relapses can happen and restarting the quit journey is still progress.

World No Tobacco Day is not just about awareness but is a call to action. Choosing to quit today may be the single most important decision for a healthier and longer life.

(Dr Akshat Malik, Senior Consultant, Head & Neck Oncology, Apollo Hospital, Delhi)

According to the Indian Council of Medical Research - National Cancer Registry Programme (ICMR-NCRP), India reports about 220,000 new cases every year, and the common treatment procedure for this disease is chemotherapy, which comes with profound fatigue, hair loss, nausea, compromised immunity, and nerve damage.

The University College London led the Optima trial, which studied over 4000 patients with the disease in different parts of the world, and a low score on the genomic test could be mediated with only hormone therapy.

The trial’s chief investigator and a professor of breast oncology at UCL, Professor Rob Stein, explains that the study used tumour biology to guide decisions instead of relying on traditional clinical procedures.

The research had 4,429 women participants above the age of 40 years with hormone-positive breast cancer. These patients were then divided into two groups based on the genomic test results by the researchers, and one group with a higher risk was given chemotherapy along with hormone therapy, while the others were only treated with hormone therapy.

What Is Breast Cancer?

Breast cancer refers to the uncontrolled growth of the cells that are found along the inner lining of breast tissue. This out-of-control growth of cells leads to the formation of tumours. The tumour can be “invasive”, meaning that it spreads to the nearby tissues outside the breast, or “in situ”, where the tumour does not spread outside the breast region.

Usually, the “in situ” type of tumour is non-cancerous and non-life-threatening. However, in the case of invasive tumours, the cancerous cell mass can spread to the lymph nodes and further metastasise, that is, spread to other body parts. About 80% times the breast cancer cases are invasive. Hence, upon noticing symptoms like lumps, changes in breast shape, or abnormal nipple discharge, you must promptly consult a doctor.

While both men and women can develop it, in 99% of cases of breast cancer, women are seen to be affected by it. Only 0.5 to 1% of men are affected due to this condition. Furthermore, the condition is mostly prevalent in women aged 50 or older.