People receiving weight-loss drug Wegovy sustained weight loss for up to four years, shedding an average of 10% of their body weight in that time, as per a new study. Wegrovy is a brand that markets semaglutide injections, that have gained widespread attention for their weight-loss effects. The study also found that Semaglutide injections boost an individual's heart health, even when weight loss doesn't take place.

The study, called SELECT, was published in journal Nature Medicine. "At four years, we see ongoing benefits of semaglutide," said Cheng-Han Chen, MD, interventional cardiologist from Cardiologist, who was not involved in the research. Besides the weight loss, it also lead to a loss in cardiovascular outcomes.

The research was conducted on 17000 adults, who had obesity but did not have diabetes. Overall, people who received once-weekly injections of semaglutide lost on average 10.2% of their body weight over the course of four years. All of the study participants continued to lose weight for about 65 weeks, a year and three months, and then their weight remained at a stable level.

Were There Any Side Effects?

What Did The Results Say?

Of the people on the highest dose of Wegovy, 68% lost at least 5% of their body weight. This compared to 21% of people on the placebo. Additionally, of the total people on Wegovy about 23% lost at least 15% of their body weight. For those in the placebo group, only 1.7% lost that much body weight.

Semaglutide Shows Heart Benefits Beyond Weight Loss

Researchers found that even individuals who did not experience significant weight reduction while on the drug saw a reduced risk of major heart events. Recent analysis of the SELECT trial data revealed that semaglutide significantly lowers the risk of heart attack, stroke, and cardiovascular-related deaths in adults with obesity or those who are overweight. Notably, the results of this study lead the US FDA to approve Novo Nordisk's Wegovy for reducing heart-related risks in this group.

What Is Semaglutide?

Are Their Any Side Effects Of Semaglutide?

Semaglutide, marketed under the brand name Wegovy, is primarily an antidiabetic medication used to treat Type 2 diabetes. It is also an anti-obesity drug used for long-term weight management. While it can be taken as a subcutaneous injection or orally, it has significant side effects. It primarily impacts your gastrointestinal tract and its side effects include constipation, nausea, abdominal pain, diarrhoea, and fatigue amongst others.

India’s growing dependence on quick, over-the-counter remedies has drawn fresh concern from a senior orthopaedic and sports surgeon in New Delhi. In a recent Instagram video, Dr Obaidur Rahman of Dr Ram Manohar Lohia Hospital warned that the country’s casual use of a common antibiotic is undermining its effectiveness and pushing India closer to a major public health challenge. His message, shared through a post and video, called attention to an urgent issue that often goes unnoticed in everyday medical choices.

What Is Azithromycin?

Azithromycin, sold under brand names such as Zithromax, Azee and Zmax, is a macrolide antibiotic prescribed for various bacterial infections. It works by slowing the growth of harmful bacteria. It does not help with viral illnesses like the common cold or flu, according to MedlinePlus.

Azithromycin Is Being Used “More Than Toffee or Roti”

Dr Rahman explained that one particular antibiotic has become so familiar in Indian homes that many people take it without a second thought. He noted that families frequently reach for this medicine to treat colds, coughs and mild fevers, despite the fact that most of these illnesses are viral. Because antibiotics do not work on viruses, this habit has increased unnecessary exposure and created ideal conditions for resistance to form.

In his post, he described the extent of the overuse by saying that the tablet is consumed even more commonly than basic household foods. This pattern, he said, has quietly pushed India into a vulnerable zone.

Azithromycin Antibiotic Resistance: Azithromycin Losing Power Against Key Bacteria

The antibiotic at the center of his warning is Azithromycin, a drug often prescribed for sore throats and upper respiratory tract infections. Dr Rahman noted that it was once effective against Mycoplasma Pneumonia, a bacterium responsible for pneumonia in adults and children.

He pointed out that this is no longer the case. According to him, India now shows an alarming 80 to 90 percent resistance to Azithromycin when treating infections caused by this bacterium. A medicine that once addressed a wide range of respiratory problems is no longer reliable for many patients.

Azithromycin: Antibiotic Resistance Already Reaching Clinics

Dr Rahman said that antibiotic resistance is not an abstract idea but something he encounters in his orthopaedic practice. He has seen cases where routine antibiotics fail entirely, leaving patients with few options. When commonly used drugs stop working, he added, treatment becomes more complicated, more expensive, and sometimes impossible.

His concern is that if such misuse continues unchecked, India could face a situation where even simple infections become difficult to manage.

The surgeon urged people to avoid taking antibiotics without proper medical advice. Most seasonal respiratory infections resolve on their own, and unnecessary drugs only add to the resistance problem. He encouraged viewers to share the information, especially with those who often purchase antibiotics over the counter.

Azithromycin Warning: Why This Warning Matters Now

Dr Rahman, who works at PGIMER and RML Hospital and specialises in bone, joint and sports injury care, said his experience treating a large volume of patients has made the issue impossible to ignore. He believes that without immediate changes in how antibiotics are used, India risks losing access to medicines that save lives in emergencies.

His message acts as a reminder that antibiotic resistance does not appear suddenly. It builds slowly through small, routine choices. And, as he warns, the cost of ignoring these early signs may be far greater than most people realise.

In a recent video, a neurosurgeon listed things he would start doing if he had to work on his brain health, ‘rebuilding it’, from scratch. Many people are focusing on health and bringing about a change in their life so that their health doesn’t suffer. If you wish to do the same but do not know where to start from, Dr Jay Jagannathan, MD, from Jay Jagannathan, MD, explains five easy steps with which you can start.

Your brain health is affected by many things around you, your habits, your diet, who you spend your time with etc. In the video Dr Jaggannath listed 5 things he would start doing if he had to start working on his brain health from the beginning.

In the caption he explained, “After years in neurosurgery, I’ve learned this: Your brain doesn’t need perfection — it needs consistency, balance, and protection. And the biggest changes often come from the simplest habits.”

5 Ways To Rebuild Your Brain Health

five key steps they would take to completely reset and improve their brain health. These strategies focus on combining strict discipline with intentional rest and mindful activities, recognizing the direct connection between physical habits and mental performance.

Sleep Schedule Discipline

The first and most critical step is maintaining strict sleep schedule discipline. This means committing to getting at least six to eight hours of quality sleep every single night without fail. If the individual has a very early start to their day, they must prioritize going to bed much earlier to ensure they meet this crucial rest quota. Prioritizing consistent sleep is essential for the brain to consolidate memories and perform necessary repairs.

Prioritize Strength Training

The second action involves incorporating regular, low-grade resistance (strength) training into the weekly routine. This exercise is especially important for people who spend long hours on their feet, like surgeons. Committing to low-grade resistance training for at least two to three days per week is considered extremely vital because physical strength and exercise directly support better circulation and overall body health, which feeds directly into improved brain function.

Embrace Regular Meditation and Mind-Body Connection

The neurosurgeon stressed the importance of dedicated time for regular meditation. They pointed out that a strong mind-body interface is crucial for endurance and clarity, particularly in demanding fields like surgery. Therefore, engaging in mindful practices such as yoga or meditation is necessary to establish and maintain that vital connection, allowing the brain and body to work together harmoniously and manage high stress levels.

Avoiding Burnout Cycles

The fourth piece of advice is to actively and consciously avoid burnout cycles. Burnout is a dangerous state of chronic stress that can severely damage both the brain's structure and its ability to function effectively. This strategy requires setting firm boundaries and intentionally managing one's workload and stress levels to prevent ever reaching a point of complete mental and physical exhaustion.

Skip the "Hero" Lifestyle

Finally, the fifth point is to firmly reject the "hero lifestyle" of skipping rest. This is the common, misguided habit of trying to power through intense work periods by constantly sacrificing necessary sleep and rest days. The neurosurgeon advises against this trend, asserting that continuous rest and consistent recovery are not optional but are absolutely non-negotiable for achieving and maintaining sustained high performance and long-term brain health.

With different careers come different work expectations. Some jobs have routine day shifts with regular working hours, popularly known as the ‘9-5’. While other jobs require round-the-clock service. However, did you know what shifts you chose to do have an effect on your health as well?

Ranking the best to worst shifts, Dr Sudhir Kumar, a Hyderabad-based neurologist, recently made a post on his social media platform. He explained that the way you schedule your work shifts can have a major impact on your long-term health. The ideal work schedule is one that matches your body's natural clock. Below is a ranking of three common shift types, based on their effects on your health.

Day Shifts: The Healthiest Option

Why Day Shifts are Best for Your Body

Working during the day perfectly matches your circadian rhythm, or internal clock. Your body is naturally built to be awake when it's light and rest when it's dark, allowing vital processes like hormone production and cell repair to function efficiently and keep your system stable.

Benefits of a Stable Schedule

Day shifts allow for quality, full sleep, which is crucial for long-term health. Workers face a lower risk of serious issues like obesity, diabetes, high blood pressure, and heart disease. This stable routine also lowers the risk of depression, anxiety, and certain cancers, making it the healthiest choice.

Fixed Night Shifts: Acceptable but Not Ideal

Partial Adaptation to Night Work

If night work is unavoidable, a consistent fixed night shift is superior to a constantly changing schedule. The benefit is that the body can establish a slightly more consistent sleep routine over time, allowing for a better partial adjustment to the reversed daytime sleep schedule than an erratic one.

Significant Remaining Health Risks

However, stable night shifts still cause chronic misalignment with the natural day-night cycle. This leads to higher long-term risks of metabolic disorders, insulin resistance, and mood problems. Additionally, it disrupts social and family life, contributing to ongoing sleep deprivation and substantial health risks.

Rotating Shifts: The Worst for Health

Maximum Disruption to the Body Clock

Constantly changing shifts are the most harmful because the internal clock cannot adapt to the varying schedule. This causes the maximum possible circadian rhythm disruption, confusing the body about when it should be awake, resting, or performing essential processes.

Increased Risk of Serious Illness

This chaotic schedule is linked to severe sleep issues and unhealthy fluctuations in stress hormones. This increases the risk of serious illnesses, including cardiovascular disease, diabetes, and mood disorders. Rapid shifts, like moving from night to morning duty, dangerously increase fatigue, raising the risk of accidents.

Final Ranking for Long-Term Health

At the end of the post Dr Kumar reiterated that the best to worst working hours for your body.

• Day Shift (Best)
• Fixed Night Shifts (Moderate Risk)
• Rotating Shifts (Worst Risk)

While there are ways to manage your health around your working hours, it is important to make sure you give your body as much stability as possible. Make sure you speak to a healthcare professional and build a routine that will help your body maintain its level of functioning while also keeping your health in check.