Wegovy Users Maintain Weight Loss for 4 Years: Here's How It Works

Updated Dec 3, 2024 | 09:00 PM IST

SummaryWegovy, is primarily an antidiabetic medication used to treat Type 2 diabetes. People receiving weight-loss drug Wegrovy sustained weight loss for up to four years
wegovy

wegovy (Credit: Canva)

People receiving weight-loss drug Wegovy sustained weight loss for up to four years, shedding an average of 10% of their body weight in that time, as per a new study. Wegrovy is a brand that markets semaglutide injections, that have gained widespread attention for their weight-loss effects. The study also found that Semaglutide injections boost an individual's heart health, even when weight loss doesn't take place.

The study, called SELECT, was published in journal Nature Medicine. "At four years, we see ongoing benefits of semaglutide," said Cheng-Han Chen, MD, interventional cardiologist from Cardiologist, who was not involved in the research. Besides the weight loss, it also lead to a loss in cardiovascular outcomes.

The research was conducted on 17000 adults, who had obesity but did not have diabetes. Overall, people who received once-weekly injections of semaglutide lost on average 10.2% of their body weight over the course of four years. All of the study participants continued to lose weight for about 65 weeks, a year and three months, and then their weight remained at a stable level.

Were There Any Side Effects?

However, people's experience with the medication varied. Researchers found no unexpected safety issues with drug during trial. In fact, most the people who withdrew from the study were those who experienced the known symptsoms of the semaglutide injections like nausea, indigestion etc. This occurred mainly during the beginning of the study, as the dose of the medicine is increased to a maximally tolerated dose.

What Did The Results Say?

Of the people on the highest dose of Wegovy, 68% lost at least 5% of their body weight. This compared to 21% of people on the placebo. Additionally, of the total people on Wegovy about 23% lost at least 15% of their body weight. For those in the placebo group, only 1.7% lost that much body weight.

Semaglutide Shows Heart Benefits Beyond Weight Loss

Researchers found that even individuals who did not experience significant weight reduction while on the drug saw a reduced risk of major heart events. Recent analysis of the SELECT trial data revealed that semaglutide significantly lowers the risk of heart attack, stroke, and cardiovascular-related deaths in adults with obesity or those who are overweight. Notably, the results of this study lead the US FDA to approve Novo Nordisk's Wegovy for reducing heart-related risks in this group.

What Is Semaglutide?

Semglutide is the synthetic version of GLP-1—a natural hormone produced in the intestines that regulates blood sugar, appetite, and digestion. Now, every time you eat, your body produces various hormones, including GLP-1. These are called Post nutrition hormones, and help you absorb the energy you just consumed. GLP-1 travels to your pancreas, prompting it to produce insulin. It also travels to the hypothalamus in your brain, which gives you the feeling of being full or satiated. Ozempic imitates this hormone, thereby, silencing the food chatter in the brain. Interestingly, for some people this food chatter is really quiet ( people with low appetite) and for others it is an outburst, (people who generally binge eat.) So with Ozempic, silencing this self-talk in the brain, people tend to lose their appetite and eventually weight.

Are Their Any Side Effects Of Semaglutide?

Semaglutide, marketed under the brand name Wegovy, is primarily an antidiabetic medication used to treat Type 2 diabetes. It is also an anti-obesity drug used for long-term weight management. While it can be taken as a subcutaneous injection or orally, it has significant side effects. It primarily impacts your gastrointestinal tract and its side effects include constipation, nausea, abdominal pain, diarrhoea, and fatigue amongst others.

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Have Dense Breasts? What Women Should Know About Their Breast Cancer Risk

Updated Sep 5, 2026 | 03:00 PM IST

SummaryDense breast tissue can increase breast cancer risk and make some cancers harder to detect on mammograms, making personalised screening discussions important.
Have Dense Breasts? What Women Should Know About Their Breast Cancer Risk

Credit: AI

Many women may come across the term "breast density" following a mammogram, but not all of them fully understand what it implies. The fact that someone has dense breasts does not mean that they have cancer or that they will definitely get it.

On the other hand, greater breast density can be linked to a higher risk of breast cancer and may also make it more difficult to detect certain cancers on a mammogram.

What Is Breast Density?

The breast density is the ratio of fibrous and glandular tissue to fatty tissue in the breast. Dense breast tissue is a normal variation and is especially frequent in younger women. It should be clear that women cannot tell themselves if their breast has dense tissue or not; it has to be assessed using breast imaging, typically a mammogram.

Breast density is usually divided into four types, going from almost all fatty tissue to very dense tissue, and women who have heterogeneously dense or extremely dense breasts are at a greater risk of developing breast cancer than women whose breasts are mainly fatty.

Also read: Alcohol-Linked Cancer Deaths Doubled In US: Colorectal Leads In Men, Breast Leads In Women

What Do Dense Breasts Indicate?

A major concern is that on a mammogram dense tissue appears white, just as many breast abnormalities—some of which are cancers—do too. This makes it harder for radiologists to spot certain abnormalities. Women need not be alarmed if their mammogram report states that their breasts are dense.

Breast density is just one of the factors to take into account when evaluating the risk of breast cancer; family history, age, past breast conditions, genetic mutations, hormonal factors, reproductive history, and lifestyle must also be considered.

It will depend on a woman's total risk level whether or not further screening is needed. Although mammography is still an important method of screening, in certain individual cases a doctor may suggest extra imaging, for example breast ultrasound or magnetic resonance imaging (MRI). Such tests are not required automatically for every woman who has dense breasts.

Also read: How Scientists Blocked Drug-Resistant Triple-Negative Breast Cancer With A Two-Step Drug Method

What Should Women Do?

Women should also know what is normal for their breasts. If a new lump is detected, there is a persistent change in the shape or size of the breast, the skin becomes dimpled, the nipple turns inwards, there is an unusual discharge from the nipple or there is ongoing discomfort, then it is advisable to have a healthcare professional look at it. Yet the majority of breast changes are not cancerous and symptoms by themselves are not enough to make a diagnosis.

Lifestyle plays a big role in maintaining breast health. One way of reducing the overall risk of breast cancer is to keep a healthy weight, remain physically active, limit alcohol intake, avoid tobacco, eat a well-balanced diet and stick to the recommended screening programmes.

Women must not regard breast density as a diagnosis. The main point is that women should not be afraid of dense breasts but should understand what this means for them. They must talk to their family doctor about their mammography report and their individual risk factors and then follow a screening programme suitable to their risk.

Breast density is therefore a valid reason for having a screening examination, not one for concern. By understanding breast density and talking to a breast specialist, women can make informed choices regarding screening and make sure that any potential abnormalities are assessed as early as possible.

By Dr. Meghal Sanghavi, Consultant Onco Surgeon, Wockhardt Hospital, Mumbai Central

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Teachers' Day 2026: How Teachers Shape Students’ Mental Health

Updated Sep 5, 2026 | 11:00 AM IST

SummaryTeachers can shape students’ mental health through supportive relationships, communication and safe classrooms. Research shows teacher well-being and experience can positively influence student well-being.
Teachers' Day 2026: How Teachers Shape Students’ Mental Health

Credit: AI Credited Image

Teachers are unarguably one of the most important influences during the early stages of a person's life. Along with learning and wisdom, teachers can also influence a child's or adolescent's mental health. Thus, they help shape students who are the future of any society or nation. This impactful profession and its contributions are celebrated worldwide, including in India.

The deteriorating mental health condition in students has escalated into a major global public health concern, heavily accelerated by academic pressure, systemic changes, and digital isolation. The World Health Organization (WHO), UNICEF, and Indian governmental bodies like NCERT have shared data that reveals a grim situation: there is a huge gap between the rising psychological distress among youth and the infrastructure available to support them.

The role of teachers in youth mental health is a topic that the study "A Shelter for the Heart: The Impact of Teacher Quality on Students' Mental Health" has thoroughly analyzed. The research, published in the journal Health Economics in 2026, was conducted in China and included 3,529 Grade 7 students, 86 classrooms, and 43 schools throughout the country. The study examines the impact of teacher quality, proxied by teacher experience, on student mental health.

How Do Teachers Protect Students' Mental Health?

According to the study, the role of the head teacher is particularly important to a student's mental well-being. While subject teachers are primarily responsible for learning, the study emphasizes that experienced teachers might do more than improve grades—they may also help protect students' mental health.

The study finds that the more experienced head teachers tended to build stronger teacher–student relationships, communicate more with parents, and create more supportive classroom environments. They were less likely to ignore or isolate struggling students and more likely to try to help them. All in all, the researchers concluded that school environments play an important role in determining adolescents’ mental health.

Mental Health On Location And Gender

The study “A study on mental health of students teacher in relation to their achievement in education psychology” by researchers at Tamil Nadu Teachers Education University, Chennai, found significant differences in mental health based on gender and location, with female and rural student-teachers reporting better mental health than their male and urban counterparts.

Teacher Distress Linked To Student Mental Health

A 2024 study published in BMC Psychology by researchers from McMaster University, the University of Sydney, the University of Johannesburg and the Hospital for Sick Children examined the relationship between teacher distress and student mental health. The researchers analysed data from 23,568 students and 1,478 teachers across 268 schools in Ontario, Canada. The researchers suggested that supporting teachers’ mental health and creating safer school environments could also benefit students’ well-being.

A 2019 study published in the Journal of Affective Disorders by researchers led by Stephen Harding also suggested that better teacher well-being was associated with better student well-being, highlighting the potential importance of supporting teachers’ mental health within schools.

Teachers Day 2026

Teachers’ Day 2026 in India is celebrated on September 5 to honour the contribution of teachers and educators. The day marks the birth anniversary of Dr. Sarvepalli Radhakrishnan, India’s first Vice President and second President, who was a distinguished philosopher, scholar and teacher. Since 1962, his birthday has been observed as Teachers’ Day in India. The occasion recognises teachers’ role in shaping students’ knowledge, character, confidence and well-being, while inspiring future generations to learn, grow and contribute to society.

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5 Important Differences Between Living And Deceased Organ Donation

Updated Sep 5, 2026 | 09:00 AM IST

SummaryDeceased organ donation can help bridge India’s severe organ shortage, while live donation offers another vital transplant pathway, each with distinct processes, possibilities, and limitations.
Organ Donation

Credits: Canva

Deceased organ donation covers our organ needs. In India, we are woefully short of organs such as kidneys and livers in cases of liver and kidney failure that need to be transplanted.

Deceased donation, as the name sounds, is a donation by people who are brain dead, whose family has now accepted and has willingly donated their organs for the benefit of the rest of the world.

Live donation, on the other hand, is a donation by living or emotionally related individuals who want to donate a kidney to a diseased patient. A live donation is usually transplanted immediately. It's done in the same centre, and both are done together, as the harvesting of the organ from the donor and transplantation are done simultaneously.

On the other hand, a deceased organ from a cadaveric donor may be harvested in a different geographical location and may be transported over time and over a lot of distance to another centre.

Deceased donation can be done for organs that cannot be transplanted by live donation, which are so consequential to a human body, such as the heart, lungs, and pancreas. They are very vital and cannot be transplanted from a live patient to another.

In a deceased organ donation, we can even donate tissues such as the cornea, skin, and blood vessels, which are required as a part of donation, as a part of other organ donation transplant programmes or, for example, in giving vision to people who have a white cornea or corneal opacity.

These are a few differences between live and deceased or cadaveric donation.

Dr. Vikram Shah Batra, Director - Urology, Kidney Transplant and Uro Oncology, Max Super Speciality Hospital, Dwarka

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