People receiving weight-loss drug Wegovy sustained weight loss for up to four years, shedding an average of 10% of their body weight in that time, as per a new study. Wegrovy is a brand that markets semaglutide injections, that have gained widespread attention for their weight-loss effects. The study also found that Semaglutide injections boost an individual's heart health, even when weight loss doesn't take place.

The study, called SELECT, was published in journal Nature Medicine. "At four years, we see ongoing benefits of semaglutide," said Cheng-Han Chen, MD, interventional cardiologist from Cardiologist, who was not involved in the research. Besides the weight loss, it also lead to a loss in cardiovascular outcomes.

The research was conducted on 17000 adults, who had obesity but did not have diabetes. Overall, people who received once-weekly injections of semaglutide lost on average 10.2% of their body weight over the course of four years. All of the study participants continued to lose weight for about 65 weeks, a year and three months, and then their weight remained at a stable level.

Were There Any Side Effects?

What Did The Results Say?

Of the people on the highest dose of Wegovy, 68% lost at least 5% of their body weight. This compared to 21% of people on the placebo. Additionally, of the total people on Wegovy about 23% lost at least 15% of their body weight. For those in the placebo group, only 1.7% lost that much body weight.

Semaglutide Shows Heart Benefits Beyond Weight Loss

Researchers found that even individuals who did not experience significant weight reduction while on the drug saw a reduced risk of major heart events. Recent analysis of the SELECT trial data revealed that semaglutide significantly lowers the risk of heart attack, stroke, and cardiovascular-related deaths in adults with obesity or those who are overweight. Notably, the results of this study lead the US FDA to approve Novo Nordisk's Wegovy for reducing heart-related risks in this group.

What Is Semaglutide?

Are Their Any Side Effects Of Semaglutide?

Semaglutide, marketed under the brand name Wegovy, is primarily an antidiabetic medication used to treat Type 2 diabetes. It is also an anti-obesity drug used for long-term weight management. While it can be taken as a subcutaneous injection or orally, it has significant side effects. It primarily impacts your gastrointestinal tract and its side effects include constipation, nausea, abdominal pain, diarrhoea, and fatigue amongst others.

We often assume that having a “normal weight” automatically means being healthy. While body weight is an important parameter, it represents only a small part of overall health. True health is far more complex than what a number on the weighing scale can convey.

Understanding The Limitations Of BMI

Body Mass Index (BMI) is widely used to classify individuals based on their weight relative to height. However, it does not differentiate between fat and muscle. As a result, someone may fall within the normal BMI range yet still have high body fat and low muscle mass, a condition known as “normal weight obesity.” Such individuals may appear healthy but remain at risk for metabolic disorders.

Why Is Body Composition Important?

Body composition analysis offers deeper insight by evaluating fat, muscle mass, and their distribution in the body. A combination of low muscle mass and excess body fat, especially around internal organs, can increase disease risk, even when overall weight appears normal.

The role of fat distribution:

All body fat is not the same. Where fat is stored matters significantly. The waist-to-height ratio is now considered a more reliable indicator than BMI, as it reflects fat distribution. A ratio above 0.5 is associated with a higher risk of conditions such as type 2 diabetes, cardiovascular diseases, and even increased mortality.

Looking beyond numbers:

Health cannot be defined by numbers alone. Factors like physical activity, nutrition, stress levels, and sleep quality play an equally critical role. Even individuals with a normal weight can experience poor metabolic health due to inadequate sleep or chronic stress.

The bigger perspective:

Good health is not just about appearance or weight, it is the result of multiple factors working together. It reflects a balance between internal processes and external lifestyle choices.

In essence, being of normal weight does not necessarily mean being healthy. To truly stay well, it is important to look beyond weight and consider the broader picture of health.

Tattoos have long raised health concerns. While they are generally safe when done under proper hygienic conditions, they still pose risks related to safety, the introduction of foreign substances into the body, and potential long-term effects, including cancer.

However, contrary to previously known health risks, a study has claimed that tattoos can actually prevent the risk of the deadliest form of skin cancer – melanoma.

The findings led by researchers from the Huntsman Cancer Institute at the University of Utah in the US showed that having two or more tattoo sessions decreased the risk of both invasive and in situ melanoma. In situ melanoma means the cancer cells remain on the skin’s surface and are more easily removed.

“We see people with two, three, and four tattoo sessions having decreasing risk, and that’s a stronger pattern than the increased risk with just one session,” said Jennifer Doherty, a researcher at Huntsman Cancer Institute.

But “this isn’t a black and white case of ‘get more tattoos, and you could lower your risk of melanoma,’” said Rachel McCarty, post-doctoral scientist at the International Agency for Research on Cancer.

Also read: Shocking! Man Gets A Tattoo On His Neck; Months Later, Flesh Turns Black And Rots Away

How Tattoos Can Prevent Melanoma

The researchers noted that the beneficial effects may be because people with several tattoos are more cautious with sun safety and take better care of their skin.

Tattoos could also form a physical barrier that blocks ultraviolet radiation or cause an immune response against precancerous cells, the researchers explained in the paper.

McCarty said those with tattoos should continue making informed decisions about skin protection.

“Tattoo artists already advise their clients to wear sunscreen and sun protection to prevent tattoos from fading,” McCarty said.

“We know wearing sunscreen is an important safety step for everyone, even without tattoos. But it’s also important for those with tattoos to take extra precautions to prevent any additional harmful components from forming in the skin when pigments break down from UV exposure.”

The researchers have called for more studies to understand the beneficial effects of tattoos.

An earlier project from Doherty’s team and a Swedish study both suggest that tattooing could be connected to an increased risk of certain blood cancers. The study also indicated a greater cancer risk for those with larger tattoos.

What Is Melanoma?

Melanoma is a serious type of skin cancer that develops in melanocytes, the cells responsible for producing melanin, the pigment that gives skin its color. While it can occur anywhere on the skin, it often develops on areas exposed to the sun, such as the face, arms, back, and legs.

Melanoma can also appear in less-exposed areas, like the soles of the feet, palms, or under the nails, particularly in individuals with darker skin tones. Although rare, melanoma may develop in the eyes, mouth, or internal organs.

The condition can be life-threatening if it spreads to other parts of the body, but early detection significantly increases the chances of successful treatment. It is often linked to excessive ultraviolet (UV) radiation from the sun or tanning beds, though genetic predisposition and family history also play roles.

Symptoms Of Melanoma

The primary sign of melanoma is a new or changing mole, freckle, or skin lesion. The "ABCDE rule" helps identify suspicious moles:

• Asymmetry: One half does not match the other.
• Border: Irregular or scalloped edges.
• Color: Multiple shades or unusual colors like red, white, or blue.
• Diameter: Larger than 6 mm (about the size of a pencil eraser).
• Evolving: Changes in size, shape, or color.

The 28 to 35-year-old age group in urban India now experiences lifestyle diseases because people now live their lives incorrectly instead of aging at a higher rate. Diabetes, high blood pressure, fatty liver, and PCOD have become routine in those under 40, developing these conditions without showing any symptoms.

Hidden Metabolic Risks

A normal BMI no longer guarantees good health. The visceral fat around organs leads to both inflammation and metabolic dysfunction. Chronic stress increases cortisol levels, resulting in insulin resistance, while people who sleep less than six hours experience further metabolic disruptions. Skipping regular check-ups leads to delayed detection of health problems.

Women’s Health And Preventive Screening

PCOS is a silent condition affecting almost 20 percent of urban Indian females. Regular consultations, including HPV vaccination, Pap smear, and hormonal evaluation, are essential.

After 25, routine tests that include fasting sugar, HbA1c, lipid profile, liver enzymes, thyroid function, Vitamin D, and B12 help detect risk early. A whole abdomen ultrasound helps detect fatty liver and silent organ damage early.

The process of detecting medical conditions at an early stage enables doctors to reverse the health issue, but patients who receive it late need permanent treatment.

Clean Eating: Trend vs Truth

The "clean eating" trend needs proper representation because it exists through incorrect information. In reality, traditional Indian dishes, such as dal, chawal, and sabzi, provide complete nutritional value. Quinoa and kale do not show any advantages over each other.

The "healthy" packaged snacks, such as multigrain biscuits and protein bars, exist mainly as marketing tools. People accept ultra-processed foods because cloud kitchens and delivery services make these foods available for consumption at home. Hidden ingredients like maida, refined oils, and excess sugar are present in everyday foods such as bread, biscuits, mithai, and even packaged atta.

The Way Forward

There is no superfood or perfect diet. Supplements cannot replace nutrition. Whole foods, home-cooked meals, timely screening, and consistent habits remain the foundation of good health. Turning 30 does not have to feel like 50, but it requires awareness and intentional choices starting now.