People receiving weight-loss drug Wegovy sustained weight loss for up to four years, shedding an average of 10% of their body weight in that time, as per a new study. Wegrovy is a brand that markets semaglutide injections, that have gained widespread attention for their weight-loss effects. The study also found that Semaglutide injections boost an individual's heart health, even when weight loss doesn't take place.

The study, called SELECT, was published in journal Nature Medicine. "At four years, we see ongoing benefits of semaglutide," said Cheng-Han Chen, MD, interventional cardiologist from Cardiologist, who was not involved in the research. Besides the weight loss, it also lead to a loss in cardiovascular outcomes.

The research was conducted on 17000 adults, who had obesity but did not have diabetes. Overall, people who received once-weekly injections of semaglutide lost on average 10.2% of their body weight over the course of four years. All of the study participants continued to lose weight for about 65 weeks, a year and three months, and then their weight remained at a stable level.

Were There Any Side Effects?

What Did The Results Say?

Of the people on the highest dose of Wegovy, 68% lost at least 5% of their body weight. This compared to 21% of people on the placebo. Additionally, of the total people on Wegovy about 23% lost at least 15% of their body weight. For those in the placebo group, only 1.7% lost that much body weight.

Semaglutide Shows Heart Benefits Beyond Weight Loss

Researchers found that even individuals who did not experience significant weight reduction while on the drug saw a reduced risk of major heart events. Recent analysis of the SELECT trial data revealed that semaglutide significantly lowers the risk of heart attack, stroke, and cardiovascular-related deaths in adults with obesity or those who are overweight. Notably, the results of this study lead the US FDA to approve Novo Nordisk's Wegovy for reducing heart-related risks in this group.

What Is Semaglutide?

Are Their Any Side Effects Of Semaglutide?

Semaglutide, marketed under the brand name Wegovy, is primarily an antidiabetic medication used to treat Type 2 diabetes. It is also an anti-obesity drug used for long-term weight management. While it can be taken as a subcutaneous injection or orally, it has significant side effects. It primarily impacts your gastrointestinal tract and its side effects include constipation, nausea, abdominal pain, diarrhoea, and fatigue amongst others.

Considered to be a key symbol of fertility and reproductive years, a woman's menstrual cycles are an integral and natural part of her life. However, they are more than just a monthly event, but instead a reflection of their hormonal, metabolic and even emotional health.

Due to genetics and other lifestyle factors, every woman experiences their cycle differently, which leaves many second-guessing about their hormonal balance, thyroid function, metabolic health, stress levels and even sleep quality.

Dr Archana Dhawan Bajaj, Gynaecologist and IVF Expert, Nurture exclusively tells Healthandme: "Knowing these patterns would guide people to understand when the changes are normal worry and when they are upheaval of a problem. Although the cycles vary among individuals, some features of such cycles are common between individuals, including the length of the cycle, flow, symptoms, as well as consistency, which are used to determine a normal state at various ages.

Here is what you should know and keep an eye out for during each phase:

The Early Years: Finding a Rhythm

Dr Maya PL Gade, Consultant, Gynaecology & Obstetrics at Kokilaben Hospital tells Healthandme: "In the first 2–3 years after menarche i.e. your first period, irregular cycles are common. Nearly 40–50 percent of adolescents do not ovulate consistently at first. The brain–ovarian hormonal axis is still maturing, so cycles may be longer than 35 days (than their typical 28 day monthly cycle) , bleeding may be heavy and cramps can feel intense.

Dr Rohan Palshetkar, Consultant IVF Specialist, Bloom IVF also warned that bleeding for more than 7–8 days continuously, soaking pads every 1–2 hours or going more than 90 days without a period may signal hormonal imbalance, clotting disorders, or conditions like PCOS.

He told Healthandme: "It is important to note that early teen cycles often happen without ovulation. For teenage girls, developing stable cycle will take some time due to ovaries adjusting to produce hormones. It is only in their late teens and early 20s that the girls will get the cycles more regular."

Normal Menstrual Cycle: According to Dr Bajaj, a normal cycle can be between 21 and 45 days. During bleeding, flow can be light, heavy, and cramps, mood swings, or even fatigue may accompany the adaptation of the organism to the hormonal changes.

Abnormal Menstrual Cycle: The expert explained: "Extensive bleeding, which needs the replacement of sanitary items every hour to two hours, long than seven or eight days, excruciating pain, or lack of periods in several months could be a sign of hormonal imbalance, thyroid complications, or polycystic ovarian syndrome."

20s and Early 30s: The Stable Phase

Talking about the post-teenager phase, Dr Gade said: "For many women, this is when cycles become more predictable, typically every 21–35 days, with 3–7 days of bleeding. Ovulation is more regular and PMS patterns are clearer. However, this is also the stage where lifestyle has a strong impact."

"Fertility is also at its peak in the 20s and early 30s, making it easy for women in this age group to become pregnant. With childbirth and breastfeeding, the chances of cycle alteration, its flow and length are high," Dr Palshetkar added.

Dr Gade also noted that high stress, poor sleep, intense exercise, crash dieting, thyroid disorders, or PCOS can disrupt ovulation and any sudden irregularity in this decade is often the body’s early warning system. A consistently painful period is also not “normal”, it may point to endometriosis or adenomyosis, both of which are frequently underdiagnosed,"

Keeping this in mind, it is essential for girls in their 20s and early 30s to track their period for regularity and flow, Dr Palshetkar advised.

Normal Menstrual Cycle: Dr Bajaj told this publication: "The average period to undergo a cycle is 21 to 35 days at an average of three to seven days with a moderate flow. The symptoms can be mild and include bloating, cramps or breast tenderness that can be easily treated."

Abnormal Menstrual Cycle: Talking about abnormal alterations, the gynaecologist said: "Excessive menstrual bleeding, cramps that impair normal life or inter-menstrual bleeding may be some of the early signs of endometriosis, fibroids, hormonal disruption or chronic stress."

Late 30s to 40s: The Hormonal Transition

Dr Gade explained: "Fertility begins to decline gradually after 35 due to reduced ovarian reserve. Cycles may shorten initially because ovulation happens slightly earlier. As women move into perimenopause, a transition that can last 4–8 years, hormone levels fluctuate unpredictably. Estrogen doesn’t simply drop; it rises and falls unevenly.

"This explains why many women notice heavier bleeding, clotting, worsening PMS, new-onset anxiety, sleep disturbances or cycles that skip months and then return. Studies suggest that up to 90 percent of women experience noticeable cycle changes during this phase.

"Importantly, very heavy bleeding at this stage should not be ignored. It can sometimes be linked to fibroids, endometrial thickening, or other structural changes in the uterus."

Moreover, Dr Palshetkar also warned: "For some, there is a noticeable and increasing gap between periods before menopause. Fertility decline is a reality in the age group, though it is not impossible to get pregnant.

Normal Menstrual Cycle: Dr Bajaj elaborated to Healthandme: "The hormonal shifts at this age may make the cycles a bit shorter or longer. Flow can either become thicker or thinner and premenstrual symptoms can be more pronounced as the body slowly transitions into perimenopause."

Abnormal Menstrual Cycle: Additionally, she said: "Very heavy bleeding, very prolonged intervals between the periods, bleeding following intercourse or sudden spotting between menstruation may be considered an issue, as these can be indicators of hormonal disorders, the presence of fibroids, or other gynecological problems."

Menopause: A New Baseline

Ultimately, Dr Gade detailed: "Menopause is diagnosed after 12 consecutive months without a period, with the average age globally around 50–51 years. Hormone levels stabilize at lower levels, and while periods stop, symptoms like hot flashes, vaginal dryness, bone density changes, and metabolic shifts may appear."

"Post-menopause, a woman’s reproductive health sees a significant decline of estrogen levels, fertility, and inability to produce any eggs. However, it still sees noticeable hormonal fluctuations and resultant health troubles.

"Facing PMS-like symptoms like mood swings and irritability is not uncommon. Medical attention is required when women notice severe pain or very heavy bleeding at

any age after menopause.

"The changes and evolution in the menstrual cycles are proof of her complete health during the course of the life she lives. And it impacts the way she lives or can live through her lifetime," Dr Palshetkar added.

Normal Menstrual Cycle: Lastly, Dr Bajaj said: "Prior to menopause, the cycles can become irregular since of the hormonal fluctuations and some symptoms like hot flushes, sleeping problems or mood swings can appear."

Abnormal Menstrual Cycle: While she noted that slight spotting is possible post-menopause due to fluctuations in estrogen and progesterone levels, the expert advised: "Post-menopausal vaginal bleeding is regarded as abnormal and needs to be medically examined because it may be due to underlying health conditions that must be addressed."

Reducing mother-to-child HIV transmission, also called vertical transmission, to zero is crucial to achieve the end AIDS target by 2030 in India, in line with the UN Sustainable Development Goals, said experts.

At the 17th National Conference of the AIDS Society of India (ASICON 2026), health officials and experts together deliberated on the progress made in the country against HIV and also called for a stronger last-mile effort to eliminate AIDS from the country.

While India has made a major reduction in vertical HIV transmission, with just 0.7 percent of infant diagnoses. But the experts stressed the need to further reduce it to zero.

From 25 percent in 2020, the vertical transmission of HIV has come down to 11.75 percent in 2023, according to Dr. Glory Alexander, President of AIDS Society of India (ASI).

“Before treatments were available to prevent vertical transmission, the risk of a newborn acquiring HIV in India ranged from 15 percent to 45 percent. The risk was nearly 45 percent among infants who were breastfed,” Dr. Alexander said.

She attributed the reduction to the introduction of antiretroviral therapy (ART) and implementation of HIV prevention and treatment guidelines.

"The government has successfully reduced the rate of infant HIV diagnosis (risk of a child getting infected with HIV due to vertical transmission) to 0.71 percent. We need to further reduce it to zero to eliminate vertical transmission of HIV,” Dr. Alexander added.

Intensifying Last-Mile Approach

India reportedly has 27-29 million pregnancies every year.

As per the latest National AIDS Control Organization (NACO) report, 83 percent of all pregnant women are tested for HIV, and 78 percent of all pregnant women are tested for syphilis in India.

“Out of an estimated 19,000 pregnant women who might be living with HIV in India, over 16,000 were reached by the government-run program and linked to services -- half of them were newly diagnosed with HIV,” Dr. Alexander said.

NACO runs 794 antiretroviral therapy centers across the country and provides free HIV treatment to 18 lakhs people with HIV.

NACO's over 700 “Suraksha Sewa Kendras” also provide preventive services for people who are at risk of acquiring HIV.

Dr. Ishwar Gilada, Emeritus President of AIDS Society of India (ASI), called India's progress "commendable."

"But to end AIDS, the last mile approach has to be accelerated and intensified manifold,” the expert said.

Increase HIV Testing Manifold

Dr. Gilada stressed the need to "ensure that all key populations know their status, and those with HIV are linked to treatment, care, and support services and remain virally suppressed".

If a person with HIV is virally suppressed, then there is zero risk of any further HIV transmission, as per the WHO, he added.

Indian data shows 9-43 times higher HIV rates (as compared to the general population) among key populations, such as men who have sex with men, transgender people, sex workers, people who inject drugs, among others.

These key populations are hard to reach, which warrants community-led and science-backed approaches, said Dr. Gilada.

Reducing Advanced HIV Disease

Despite commendable progress in India’s HIV response, there is a huge number of cases of advanced HIV disease (AHD) -- about one third of all people living with HIV in the country, the experts said.

The World Health Organization (WHO) defines AHD as a CD4 count less than 200 cells per cubic millimeter/ or WHO stage 3/4 in adults/adolescents, and all children less than 5 years old.

It indicates a severely weakened immune system, high mortality risk, and vulnerability to infections like TB and cryptococcal meningitis.

AHD cases in India are majorly among those who are HIV infected but are not on lifesaving antiretroviral treatment.

"This could be because HIV infection is undiagnosed in people until they present with opportunistic infections to healthcare centers, or they were not able to adhere to the treatment for a range of reasons,” said Dr Trupti Gilada, Joint Secretary, AIDS Society of India (ASI).

TB, which is preventable and treatable, is the most common opportunistic infection among people with HIV.

Another concern is the rising antimicrobial resistance in HIV patients. Studies show that people with HIV are 2-3 times more likely to get drug-resistant forms of TB.

Just few days ago, the world witnessed a personal documentary film bagging BAFTA Award 2026. The film is titled This Is Endometriosis. The film is a personal story of director Georgie Wileman, who was diagnosed with the condition a decade after she had first shown her symptoms. The film brings the attention back on dismissal of women's pain, which has been normalized for ages.

This is not the only instance of women's pain being dismissed. Instagram and other social media platforms are flooded with women sharing their experiences of getting intrauterine contraceptive device or an IUD inserted without anesthesia. The pain is debilitating.

Another report, from India's capital city by PARI (People's Archive of Rural India) mentions a case of Deepa (name changed) who had a copper-T (IUD) inserted, right after her C-section. After two years, she experienced menstrual irregularities and heavy bleeding. She visited several doctors, one of whom, even dismissed it as just weakness, while prescribing calcium and iron tablets for her. In other instances, her copper-T could not be located, until she got an X-ray done, which noted: 'The copper-T is seen in situ in hemipelvis region.' The PARI report quotes West Delhi-based gynecologist Dr Jyotsna Gupta, "There are high chances that a copper-T may get tilted if it is inserted soon after delivery or a C-section.This is because in both cases the uterus cavity is enlarged then, and takes time to set itself to normal. While it is doing so, the inserted copper-T may change its axis and get tilted. It may also get displaced or get tilted if a woman experiences severe cramps during menstruation.”

The report also quotes ASHA worker Sushila Devi saying that they hear many women complaining about copper-T. "Many times, they tell us that it has 'reached their stomach' and they want to get it removed." However, like this case, in many other cases too, their pain is often ignored.

When Health and Me spoke to Dr Archana Dhawan Bajaj, gynecologist and Delhi-based IVF specialist, she said that physical pain and emotional distress in women is often normalized because the system "assumes that women's bodies are always in a state of flux and therefore leads to many women being undiagnosed or dismissed and delayed for treatment of a serious nature."

Dr Sonu Taxak, who is a senior IVF Consultant and Director at Yellow Fertility also told Health and Me that historically, women's symptoms were poorly studied, so for any pain, "hormonal fluctuation became a convenient explanation".

Read: The Hidden Cost of Extreme Fitness On Women’s Bodies | Women's Day Special

Women Bodies Are Meant To Bear Pain

A popular monologue from Fleabag says, "Women are born with pain built in." The powerful monologue is a reminder of how women carry pain and are often unheard so much so that society makes a woman believe that she is meant to bear it. While there is no scientific evidence that verifies that women have a higher pain tolerance than men (British Journal of Anaesthesia, 2013), historically their pain have been ignored. Dr Taxak points out that research consistently shows women’s pain is more likely to be dismissed as emotional or anxiety-related. "While awareness is improving, unconscious bias still exists. Pain should be evaluated based on clinical evidence, not gender-based perception."

A Guardian report from 2020 talks about how women are shamed for asking for painkillers. The report mentions Kate, who was in a 26-hour labor and when she asked for epidural, she was denied it. "The first time the midwives said I wasn't far enough along. The second time, they said I didn't need it. Finally, they said I was too far along."

Many women are shamed for asking for epidural, or are often scared. Yashasvi Arora (name changed) delivered her baby in January 2025 in a Delhi hospital said that her mother had told her to not opt for epidural as it causes chronic back problems that linger throughout one's life. However, science finds no such evidence of any claim. While back pain is common, but it does not stay forever, as notes Cleveland Clinic.

"Childbirth pain has been culturally romanticized as something to 'endure'. But medically, an epidural is a safe and evidence-based pain relief option. Choosing comfort does not diminish strength, It reflects informed decision-making," says Dr Taxak.

Pop culture plays a significant role in romanticization of labor pain. An advertisement by Indira IVF opens with a woman in labor pain, sweating and screaming and in the next scene, she says, "This is my life's best moment". Dr Archana says, "Pain relief (i.e., epidurals) becomes defined as a form of weakness because society favors natural childbirth as a true "test of endurance." Additionally, society often manifests culture as a glorified sacrifice made by the mother and that to ask for help is a sign of failure."

The cycle of pain does not end there, women are also shamed for postpartum, with many, especially men on the internet claiming that it is not a real thing. A new trend of 'Last Generation of the Innocent Mother' has taken over the internet that glorifies mothers who did not express their problems or were often shamed for it. However, the reality is quite different from what trends on the internet.

Read: Navigating Postpartum: The Emotional and Physical Impact on New Mothers

“I am a very positive person. I know I can handle anything. So, when my friends would tell me their stories of postpartum, I would tell myself that I could handle it. I could talk myself out of it. But to my surprise, it was very difficult. My body and my mind went through so much,” says Akanksha Thapliyal, 34 from Siliguri, a creative consultant, who became a mother at 33. Thapliyal shares that there were days when she would just cry, without even knowing the reason. At times, everyone felt like her enemy, including her husband.

A mother from East Tennessee, Tiffany Toombs Clevinger, now 39, shares she was 37 when she had her baby and her first feeling was, “Oh no, what did we just do?” She was in disbelief and did not know what to do to take care of her child.

Both mothers struggled with breastfeeding and Thapliyal also complained of pain while feeding her child. However, her mother told her that it was normal. The reality is, it was not.

"Postpartum depression is often underdiagnosed because symptoms are normalized or overlooked. While mild discomfort in breastfeeding could occur initially, persistent or severe pain is not normal," points out Dr Taxak.

Pain And Discomfort Exist Only For Men

Birth control pill is often the burden on women, and when the idea of male contraception was first discussed in 1970s, the research came to a halt. The pill never made it to market. In November 2016, Susan Scutti reported in CNN that the study was cut short due to the side effects of the pill. The report Male birth control shot found effective, but side effects cut the study short. Another report by NPR titled Male Birth Control Study Killed After Men Report Side Effects also seconded the claim.

Read: Explained: The History Of Birth Control Pills And Other Alternative

While for women, those who are on birth control pills are prone to headaches, breast tenderness, acne, nausea, weight gain, irregular menstruation, mood changes, and decreased libido.

Dr Archana explains, the disparity of how women and men are treated medically in terms of contraceptive responsibility remains pervasive due to long-standing societal and medical expectations. "Trials for male contraceptives are often stopped due to the mildly adverse effects of men, while women have been expected to suffer similar or perhaps even more serious effects for a much longer period. Ultimately this further illustrates the gendered tolerance men have witnessed in the medical world, wherein the discomfort of women is often treated as 'the norm,' while any form of adverse side effect for men exhibits heightened scrutiny and ultimately leads to decisions to cease the trials."

Listening To Women's Pain

With such instances, it becomes more so important on International Women's Day on how much of women's pain is still being normalized instead of treated. For decades, medicine and society have often asked women to tolerate discomfort quietly.

International Women’s Day, at its core, is about recognizing women’s voices and experiences. In healthcare, that means something very practical: believing women when they say something is wrong. Because sometimes, the most powerful step toward better care is not a new technology or treatment. It is simply listening.