People receiving weight-loss drug Wegovy sustained weight loss for up to four years, shedding an average of 10% of their body weight in that time, as per a new study. Wegrovy is a brand that markets semaglutide injections, that have gained widespread attention for their weight-loss effects. The study also found that Semaglutide injections boost an individual's heart health, even when weight loss doesn't take place.

The study, called SELECT, was published in journal Nature Medicine. "At four years, we see ongoing benefits of semaglutide," said Cheng-Han Chen, MD, interventional cardiologist from Cardiologist, who was not involved in the research. Besides the weight loss, it also lead to a loss in cardiovascular outcomes.

The research was conducted on 17000 adults, who had obesity but did not have diabetes. Overall, people who received once-weekly injections of semaglutide lost on average 10.2% of their body weight over the course of four years. All of the study participants continued to lose weight for about 65 weeks, a year and three months, and then their weight remained at a stable level.

Were There Any Side Effects?

What Did The Results Say?

Of the people on the highest dose of Wegovy, 68% lost at least 5% of their body weight. This compared to 21% of people on the placebo. Additionally, of the total people on Wegovy about 23% lost at least 15% of their body weight. For those in the placebo group, only 1.7% lost that much body weight.

Semaglutide Shows Heart Benefits Beyond Weight Loss

Researchers found that even individuals who did not experience significant weight reduction while on the drug saw a reduced risk of major heart events. Recent analysis of the SELECT trial data revealed that semaglutide significantly lowers the risk of heart attack, stroke, and cardiovascular-related deaths in adults with obesity or those who are overweight. Notably, the results of this study lead the US FDA to approve Novo Nordisk's Wegovy for reducing heart-related risks in this group.

What Is Semaglutide?

Are Their Any Side Effects Of Semaglutide?

Semaglutide, marketed under the brand name Wegovy, is primarily an antidiabetic medication used to treat Type 2 diabetes. It is also an anti-obesity drug used for long-term weight management. While it can be taken as a subcutaneous injection or orally, it has significant side effects. It primarily impacts your gastrointestinal tract and its side effects include constipation, nausea, abdominal pain, diarrhoea, and fatigue amongst others.

Yoga can act as a "polypill" by addressing multiple underlying factors that contribute to lifestyle diseases, according to Dr. Rima Dada, Professor at the All India Institute of Medical Sciences (AIIMS), who has been studying yoga and its impact on lifestyle disorders for the past 20 years.

Speaking about her research, Dr. Rima said yoga is a profound science, technology, and art of living that can tackle factors that set the stage for a wide range of diseases.

Yoga May Benefit Multiple Health Conditions

According to Dr. Rima, yoga can help address conditions including hypertension,

• coronary artery disease,
• polycystic ovarian syndrome (PCOS),
• unexplained male factor infertility,
• primary open-angle glaucoma,
• autoimmune diseases,
• rheumatoid arthritis,
• Alzheimer's disease.

• accelerated ageing,
• shorter telomeres,
• persistent activation of the hypothalamic-pituitary-adrenal axis,
• a dysregulated immune system,
• high levels of stress and anxiety,
• inflammation,
• oxidative stress.

Yoga's For Oxidative Stress And Inflammation

Also read: Yoga Enriches Every Aspect of Life, From Fitness to Inner Peace, Says PM Modi

Dr. Rima said evidence-based studies conducted by her team have shown that yoga addresses these underlying factors.

According to the findings, yoga reduces oxidative stress by increasing the expression of various antioxidants. It also improves mitochondrial health and reduces free radicals produced as by-products of ATP production.

The studies further showed that inflammation decreases because the expression of genes coding for anti-inflammatory factors increases, while the expression of genes that promote inflammation declines.

Yoga May Support Brain Health

The research also found that yoga increases the expression of genes involved in DNA repair. In addition, yoga promotes parasympathetic dominance, resulting in increased rest, repair, and digestion.

Dr. Rima said yoga also positively modulates the epigenome and increases the expression of factors beneficial for overall health. She noted that yoga promotes brain health, improves mental well-being, and enhances the production of factors associated with neurogenesis in key areas of the brain. These changes may help improve memory and build emotional resilience.

Gut-Brain Axis and Immune Health

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Dr. Rima said yoga has also been shown to improve gut microbial flora, helping maintain the integrity of the gut-brain axis.

According to her, this supports the secretion of factors that help maintain immune, endocrine, and mental health.

Yoga Is An Entire Lifestyle

Emphasizing that yoga extends beyond physical postures, Dr. Rima said it is an entire lifestyle that includes diet, asanas, pranayama and dhyana.

She said yoga and asanas help bring the body into proper geometry and alignment, while also improving flexibility, range of motion and neuromuscular coordination.

This alignment, she explained, enables more effective breathing. Nasal inhalation and exhalation activate certain areas of the brain that promote a state of relaxed wakefulness.

Yoga Is The Need of The Day

Dr. Rima said effective breathing increases blood flow to the brain and raises nitric oxide levels, which help improve circulation while reducing inflammation and oxidative stress.

"Thus, yoga is a polypill and is the need of the day," she said.

Heavy menstrual bleeding caused by fibroids and other gynecological conditions is a major but often overlooked contributor to anemia among Indian women, said Dr. Roma Sinha, Chief Gynecologist and Director of Gynecological Robotic Surgery at Apollo Hospitals, Hyderabad, today.

Speaking at the Times Network India Health Summit 2026 at Hyderabad, Dr. Sinha highlighted how many women normalize excessive menstrual bleeding and delay seeking medical attention, often leading to severe anemia and a reduced quality of life.

Fibroids And Heavy Bleeding Behind Anemia

According to Dr. Sinha, it is not uncommon for women to visit her clinic with hemoglobin levels as low as five or six grams per deciliter.

"Most of the time, it is not nutritional anemia. Women lose so much blood during their menstrual cycles that they are unable to rebuild their hemoglobin levels," she said.

While national programs such as Anemia Mukt Bharat focus heavily on pregnant women, Dr. Sinha pointed out that anemia occurring during other stages of a woman's life often goes unnoticed.

She said many women learn from family members and friends that heavy bleeding is "normal" and simply continue to suffer without seeking treatment.

Also read: Violence Against Doctors Is A National Concern, Says IMA Dilip P. Bhanushali

Fatigue And Poor Quality Of Life

Beyond the underlying disease, Dr. Sinha emphasized the impact heavy menstrual bleeding has on women's daily lives.

"Many women think they are tired because of stress, work, or family responsibilities. But often it is low hemoglobin and iron deficiency causing that fatigue," she said.

The expert noted that a simple hemoglobin test can help diagnose anemia, yet many women continue to prioritize the health of their families over their own well-being.

Lack of Awareness

Dr. Sinha identified lack of awareness and negligence as two major reasons why women delay medical consultations.

"Heavy bleeding occurs only for a few days every month, so women tend to tolerate it and move on. Many don't realize that it is treatable and that ignoring it can lead to dangerously low hemoglobin levels," she said.

The expert stressed the need for greater public awareness and open conversations about menstrual health.

"It should not be a taboo to talk about heavy menstrual bleeding," she added.

Surgery Not The Only Treatment Option

Read More: Childhood Obesity Is A 'Do or Die' Crisis, Experts Warn

A common fear among women, Dr. Sinha said, is surgery. Many patients avoid consultations because they assume treatment will automatically mean a hysterectomy —the surgical removal of the uterus— after which pregnancy is impossible, the top gynecologist said. However, she clarified that surgery is not the only option available for fibroids.

"Fibroids are largely benign tumors. Women today have choices, including medical management, non-invasive treatments, myomectomy, or hysterectomy, depending on their individual needs and preferences," she said.

The expert added that modern technologies such as robotic surgery have significantly improved outcomes for women requiring treatment.

Dr. Sinha also highlighted long-term research conducted on women who underwent robotic surgery for fibroids.

"We followed patients for ten years and found that 86.3 per cent conceived and delivered successfully after surgery," she said.

The findings, she noted, should reassure younger women concerned about fertility after fibroid treatment.

Early Diagnosis

Read To Know: AI Cannot Replace Doctors, It Can Only Complement, Says Dr Santosh Sivaranjani

While early detection cannot eliminate fibroids completely, Dr. Sinha said it can prevent severe anemia and improve overall quality of life. "Current treatments can control symptoms and act as bridge therapies, helping women avoid complications and delay more definitive treatment when appropriate," she explained.

'Don't Ignore Heavy Bleeding'

In her message to women, Dr. Sinha urged them to listen to their bodies and seek help when they notice abnormal menstrual bleeding.

"If you feel your periods are heavier than normal, don't ignore it. Get a simple hemoglobin test and consult a gynecologist," she said.

Dr. Sinha also called on families, particularly men, to support women in seeking care and to pay attention when they complain of persistent fatigue or excessive menstrual bleeding.

Violence against healthcare professionals is no longer just a workplace issue but a national concern that threatens the very foundation of India's healthcare system, said Dr Dilip Bhanushali, Immediate Past National President of the Indian Medical Association (IMA), at the ongoing Times Network India Health Summit 2026 in Hyderabad.

Addressing a session on Building Trust in Healthcare: Addressing Violence Against Healthcare Professionals, the expert highlighted the alarming rise in attacks on doctors, nurses, and other healthcare workers, calling for urgent legal reforms, stronger security measures, and a renewed effort to rebuild trust between patients and medical professionals.

Over 60% Healthcare Workers Face Violence

Drawing attention to the scale of the problem, the Dr Dilip said studies show that more than 60 per cent of healthcare workers in India have experienced some form of violence, with verbal abuse being the most common. Emergency departments continue to be among the most vulnerable areas for such incidents.

"Behind every statistic is a doctor who went home shaken, a nurse who cried silently after a night shift, or a medical student questioning their future in the profession," he said.

The growing normalization of violence against healthcare workers, he warned, is one of the most worrying aspects of the crisis.

Doctors Become Targets When Outcomes Go Wrong

Dr. Dilip noted that while doctors are often celebrated when treatments succeed, they frequently become targets when outcomes are unfavorable despite their best efforts.

"Medicine is not mathematics. Not every illness can be cured, not every complication can be predicted, and not every life can be saved," he said.

While emphasizing that accountability and transparency are essential when mistakes occur, the expert stressed that violence can never be justified. "A complication is not necessarily misconduct, and a bad outcome is not necessarily a crime," he added.

Trust Is The Oxygen of Healthcare

Also read: Childhood Obesity Is A 'Do or Die' Crisis, Experts Warn At Times Network India Health Summit 2026

Calling trust the foundation of effective healthcare delivery, Dr. Dilip said the erosion of trust between patients and doctors has serious consequences for the entire healthcare ecosystem.

"Without trust, every prescription is questioned, every diagnosis is doubted, and every conversation becomes a confrontation," he noted.

The Indian Medical Association has consistently maintained that violence against healthcare workers is not merely an attack on an individual doctor but on the healthcare system itself, he added.

Demand for Stronger Laws and Faster Justice

The IMA leader reiterated the association's long-standing demand for a comprehensive central law to protect healthcare personnel and institutions.

While acknowledging that several states have enacted legislation against violence towards healthcare workers, they argued that enforcement remains inconsistent.

The association is seeking stricter penalties, mandatory registration of cases, speedy investigations, and time-bound prosecution of offenders.

"Laws on paper alone cannot protect healthcare workers. Enforcement is equally important," Dr. Dilip said.

Hospitals Must Be Designated Safe Zones

Read More: Times Now Health Summit 2026: AI Cannot Replace Doctors, It Can Only Complement, Says Dr Santosh Sivaranjani

Beyond legislation, Dr Dilip said called for practical measures to improve safety within healthcare facilities.

Recommendations included regular security audits, adequate CCTV coverage, trained security personnel, emergency response systems, and controlled-access areas within hospitals.

"No healthcare professional should fear for their safety while caring for patients," he said.

"The future of healthcare cannot be built on fear; it must be built on trust," Dr Dilip said.

Healthcare professionals, he added, continue to serve despite long hours, emotional strain, and personal sacrifices, and deserve both protection and respect.

"Protect the healer, and you protect healing itself," Dr Dilip said.

The ongoing Times Now India Health Summit 2026 – South Edition in Hyderabad is bringing together leading voices from government, medicine, research, and the healthcare industry to discuss the future of India's healthcare system.

The summit featured renowned doctors, policymakers, hospital leaders, researchers, and healthcare innovators, with discussions spanning preventive healthcare, artificial intelligence, women's health, public health policy, and medical innovation.