People receiving weight-loss drug Wegovy sustained weight loss for up to four years, shedding an average of 10% of their body weight in that time, as per a new study. Wegrovy is a brand that markets semaglutide injections, that have gained widespread attention for their weight-loss effects. The study also found that Semaglutide injections boost an individual's heart health, even when weight loss doesn't take place.

The study, called SELECT, was published in journal Nature Medicine. "At four years, we see ongoing benefits of semaglutide," said Cheng-Han Chen, MD, interventional cardiologist from Cardiologist, who was not involved in the research. Besides the weight loss, it also lead to a loss in cardiovascular outcomes.

The research was conducted on 17000 adults, who had obesity but did not have diabetes. Overall, people who received once-weekly injections of semaglutide lost on average 10.2% of their body weight over the course of four years. All of the study participants continued to lose weight for about 65 weeks, a year and three months, and then their weight remained at a stable level.

Were There Any Side Effects?

What Did The Results Say?

Of the people on the highest dose of Wegovy, 68% lost at least 5% of their body weight. This compared to 21% of people on the placebo. Additionally, of the total people on Wegovy about 23% lost at least 15% of their body weight. For those in the placebo group, only 1.7% lost that much body weight.

Semaglutide Shows Heart Benefits Beyond Weight Loss

Researchers found that even individuals who did not experience significant weight reduction while on the drug saw a reduced risk of major heart events. Recent analysis of the SELECT trial data revealed that semaglutide significantly lowers the risk of heart attack, stroke, and cardiovascular-related deaths in adults with obesity or those who are overweight. Notably, the results of this study lead the US FDA to approve Novo Nordisk's Wegovy for reducing heart-related risks in this group.

What Is Semaglutide?

Are Their Any Side Effects Of Semaglutide?

Semaglutide, marketed under the brand name Wegovy, is primarily an antidiabetic medication used to treat Type 2 diabetes. It is also an anti-obesity drug used for long-term weight management. While it can be taken as a subcutaneous injection or orally, it has significant side effects. It primarily impacts your gastrointestinal tract and its side effects include constipation, nausea, abdominal pain, diarrhoea, and fatigue amongst others.

Irritable Bowel Syndrome (IBS) is a common but often overlooked gastrointestinal disorder; as a result, IBS is very prevalent, with less than 15% being diagnosed.

Individuals frequently experience recurrent symptoms such as bloated abdomen, abdominal pain, gas, diarrhea, or constipation, and normalize these symptoms over time or attribute them to "something they ate" or everyday stresses. Therefore, IBS remains undiagnosed for many years.

Why Diagnosis Is Often Delayed

One reason for this delay in being diagnosed is that the symptoms occur intermittently. It is also important to note that the presentation of these symptoms is inconsistent and unpredictable; there may be episodes where the IBS can last many days, and then completely resolve, thus providing a false sense of relief. Therefore, many individuals choose to delay consulting with a physician due to their belief that the symptoms they are experiencing are not serious.

Stigma Around Digestive Health

Another contributing factor is that there is still a degree of reluctance or discomfort associated with discussing problems related to the gastrointestinal tract openly; this only further complicates under-reporting statistics.

A ‘Functional’ Disorder Adds to Confusion

Finally, IBS is a functional disorder. Therefore, routine diagnostic testing will not reveal any visible abnormalities. Many patients may assume that the symptoms they are experiencing are not "real" or are not significant enough to warrant seeking medical attention, even though the discomfort they experience can be quite significant and affect their daily lives.

If you continually ignore symptoms of IBS, it will hurt your quality of life, productivity, and mental health. If you have persistent discomfort, you are likely to develop anxious feelings about eating, socializing, and travelling. Furthermore, if you don't manage your symptoms, you may experience a combination of untreated IBS with one or more other illnesses that are either gastrointestinal or metabolic; consequently, establishing the correct diagnosis for your IBS will be increasingly difficult as time goes on.

Why Early Action Matters

It is of the utmost importance to identify and respond to early warning signs of IBS as quickly as possible. A thorough evaluation can rule out other illnesses and provide a pathway for appropriate management, including dietary modifications, stress management techniques, and, if necessary, medical treatment.

Once you address your IBS, you will experience better control of your symptoms and eliminate the long-term consequences of IBS, both physically and psychologically.

India has long been considered a low-incidence country for colorectal cancer, but that picture is changing fast. Based on current trends, India could see a sharp rise in colorectal cancer cases and deaths by 2035, driven largely by rapid urbanization and the widespread adoption of westernized lifestyles. The burden is expected to hit urban populations hardest, making timely awareness and screening no longer optional, but essential.

A Younger Face On An Older Disease

Perhaps the most alarming shift is who is getting diagnosed. Over the past decade, there has been a worrying increase in colorectal cancer among younger Indians, patients in their 40s and 50s who would not traditionally have been considered high risk. Clinical observations suggest that as many as one in five colorectal cancer patients today falls into this younger age group.

What makes this particularly concerning is not just the frequency, but the severity. These younger patients are presenting with more node-positive disease and poorer tumor histology than their older counterparts. The cancer is often more aggressive and more advanced at the time of diagnosis, a direct consequence of delayed recognition and a lack of awareness among younger demographics.

Symptoms That Are Too Often Dismissed

The red flags for colorectal cancer are not subtle. Rectal bleeding, persistent abdominal discomfort, pain, and a noticeable change in bowel habits are the most common warning signs. In some cases, patients may present with bowel obstruction. And yet, these symptoms are routinely dismissed, mistaken for hemorrhoids, acidity, or irritable bowel syndrome, until the disease has progressed significantly.

The message from clinicians is unambiguous – never ignore these symptoms, regardless of age.

Who Is At Highest Risk?

While colorectal cancer can affect anyone, certain individuals carry a substantially higher risk and should be especially vigilant. These include those with a family history of colorectal or uterine cancer, patients with inflammatory bowel disease, individuals with multiple gastrointestinal polyps, and those with features suggestive of hereditary cancer syndromes.

For anyone with a relevant family history, specialists strongly advise seeking a formal genetic risk assessment. Early identification of hereditary risk can be lifesaving, and the conversation with a doctor should not be delayed.

Screening: The Most Powerful Tool Available

The most effective way to defeat cancer is to detect it early, ideally before it becomes cancer at all.

While routine population-level colorectal cancer screening is not yet standard practice in India, advanced diagnostic tools are increasingly available at quaternary care centers. These include colonoscopy, fecal occult blood testing, CT colonography, flexible sigmoidoscopy, double-contrast barium enema, and DNA stool testing. Importantly, these methods can identify precancerous polyps before malignant transformation, providing an opportunity to intervene well before a cancer develops.

In Western countries, organized screening programs have already demonstrated meaningful reductions in colorectal cancer mortality. The tools are now available in India; what is needed is the awareness and urgency to use them.

Treatment Has Never Been More Sophisticated

For those who do receive a colorectal cancer diagnosis, the landscape of treatment has transformed dramatically over the past two decades. Leading oncology centers in India now follow a personalized, multidisciplinary approach combining surgery, combination chemotherapy, radiation where indicated, and biomarker-guided targeted therapies tailored to each patient's tumor profile.

In metastatic disease, targeted therapies designed around tumor characteristics and biomarkers have revolutionized outcomes. Minimally invasive techniques, including laparoscopic surgery and advanced robotic surgical systems such as the Da Vinci Xi, have made recovery faster, less painful, and significantly shorter, improving quality of life alongside survival rates.

Even Metastatic Disease Is Not A Death Sentence

Advanced or metastatic colorectal cancer does not mean the end of hope. With modern chemotherapy and immunotherapy protocols, many patients with liver or lung metastases are being successfully downstaged, allowing surgical intervention that was previously not possible.

Specialized centres in India are now performing high volumes of parenchyma-sparing, image-guided liver resections for colorectal liver metastasis, with outcomes comparable to the best institutions globally.

The Way Forward

The priorities are clear: build awareness around symptoms, promote regular screening among high-risk individuals, and ensure that those diagnosed, at any stage, have access to specialized, multidisciplinary care.

Colorectal cancer, even when diagnosed late, is increasingly a beatable disease. The combination of early detection, advanced treatment, and the right medical expertise means that for a growing number of patients, a return to normal life is not just possible, it is the expectation.

Colorectal Cancer is not only one of the most common and deadly cancers, but is also one of the most preventable ones.

Unlike many other cancers, patients have a clear window of opportunity to stop it before it even begins. Almost always, these cancers start as small growths called polyps or precancerous lesions on the inner lining of the colon or rectum.

There is a long interval of time before polyps develop into cancer. During this time, they can be removed if they are identified. If a doctor removes a precancerous polyp during a routine screening, they would not only have nipped the cancer in the bud, but would have also prevented it from occurring.

However, there is a persistent taboo surrounding discussing bowel movements and other risk factors, and public understanding of its symptoms and crucial screening procedures frequently lags.

Dr Jeremy Clark, a consultant general surgeon specializing in colorectal diseases at Nuffield Health in Brighton, has underscored five critical warning signs the public must recognize, The Independent reported.

1. Blood in stool

“Passing blood when you go to the toilet is a worrying feature that you should flag to your GP,” Clark said, adding that the color can vary from bright red to almost black.

“If you see blood in the stools, particularly darker-colored blood or blood that’s actually mixed in with the stools, just once, and it’s significant, that should be reported to your doctor straight away. Don’t wait for that to keep on happening,” he added.

2. Changes in Bowel Habits

Dr. Clark stated that although more constipation may not be a risk factor, any sudden changes in bowel movements that last for a couple of weeks and do not go back to normal must be checked.

“If your bowels go from working once a day like clockwork, and then suddenly you’re going two or three times a day, and the bowels are a bit looser, that’s something that needs to be looked into,” the expert added.

3. Abdominal pain

Dr Clark highlighted that bowel cancers can cause abdominal pain, even in the initial days.

4. Bloatedness

The feeling of being 'quite often’ bloated may also indicate that something is going wrong in the bowel, Dr. Clark said.

5. Unexplained weight loss

Bowel cancers can impact digestion and cause weight loss

Dr Clark said that as these symptoms are common with other conditions, such as hemorrhoids or irritable bowel syndrome (IBS), people often ignore or easily dismiss these symptoms. He urged patients not to ignore and visit their doctor if they notice any of these symptoms.

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What Is Colorectal Cancer?

The American Cancer Society notes that colorectal cancer is a cancer that starts in the colon or the rectum. Colorectal cancer impacts around 1.9 million people every year, noted the World Health Organization (WHO) as per its 2022 data.

It is a disease of the large bowel and a type of cancer that originates from the rectum or colon. A person's colon, cecum, rectum, and anus make up the large intestine.

According to experts, if you are above 45 years of age or have high-risk factors, you need to take the initiative to be screened.

The FIT (Fecal Immunochemical Test) is a simple, non-invasive at-home stool test kit that can collect a small sample of your feces, which can then be tested.

“If it comes back as positive, that means there is blood in your stools which needs to be investigated,” Clark said, adding that the next step is typically the Colonoscopy – the gold standard.