People receiving weight-loss drug Wegovy sustained weight loss for up to four years, shedding an average of 10% of their body weight in that time, as per a new study. Wegrovy is a brand that markets semaglutide injections, that have gained widespread attention for their weight-loss effects. The study also found that Semaglutide injections boost an individual's heart health, even when weight loss doesn't take place.

The study, called SELECT, was published in journal Nature Medicine. "At four years, we see ongoing benefits of semaglutide," said Cheng-Han Chen, MD, interventional cardiologist from Cardiologist, who was not involved in the research. Besides the weight loss, it also lead to a loss in cardiovascular outcomes.

The research was conducted on 17000 adults, who had obesity but did not have diabetes. Overall, people who received once-weekly injections of semaglutide lost on average 10.2% of their body weight over the course of four years. All of the study participants continued to lose weight for about 65 weeks, a year and three months, and then their weight remained at a stable level.

Were There Any Side Effects?

What Did The Results Say?

Of the people on the highest dose of Wegovy, 68% lost at least 5% of their body weight. This compared to 21% of people on the placebo. Additionally, of the total people on Wegovy about 23% lost at least 15% of their body weight. For those in the placebo group, only 1.7% lost that much body weight.

Semaglutide Shows Heart Benefits Beyond Weight Loss

Researchers found that even individuals who did not experience significant weight reduction while on the drug saw a reduced risk of major heart events. Recent analysis of the SELECT trial data revealed that semaglutide significantly lowers the risk of heart attack, stroke, and cardiovascular-related deaths in adults with obesity or those who are overweight. Notably, the results of this study lead the US FDA to approve Novo Nordisk's Wegovy for reducing heart-related risks in this group.

What Is Semaglutide?

Are Their Any Side Effects Of Semaglutide?

Semaglutide, marketed under the brand name Wegovy, is primarily an antidiabetic medication used to treat Type 2 diabetes. It is also an anti-obesity drug used for long-term weight management. While it can be taken as a subcutaneous injection or orally, it has significant side effects. It primarily impacts your gastrointestinal tract and its side effects include constipation, nausea, abdominal pain, diarrhoea, and fatigue amongst others.

Inflammatory Bowel Disease (IBD) is no longer a rare disease in India. Over the last decade, gastroenterologists across the country have seen a steady rise in patients suffering from ulcerative colitis and Crohn’s disease, the two main forms of IBD.

Yet despite increasing numbers, awareness about the disease remains surprisingly poor. Many patients continue to suffer silently for years because their symptoms are misunderstood, ignored, or mistaken for other common intestinal illnesses.

What Is IBD?

IBD is a chronic inflammatory condition of the digestive tract caused by an abnormal immune response. Unlike routine stomach infections, it is not simply a “bad stomach” or food-related issue.

Patients commonly experience persistent diarrhea, blood in stools, abdominal pain, weight loss, fatigue, and loss of appetite. In children and young adults, it may also affect growth, nutrition, and quality of life.

Why Diagnosis Is Often Delayed

Unfortunately, in India, these symptoms are often initially treated as recurrent food poisoning, piles, irritable bowel syndrome, or intestinal infections. Many patients repeatedly receive antibiotics without proper evaluation.

Some even undergo unnecessary treatments before finally reaching a specialist. This delay in diagnosis can lead to severe complications, including intestinal strictures, fistulas, malnutrition, hospitalization, and the need for surgery.

IBD vs Intestinal Tuberculosis

One major reason for underdiagnosis is the overlap of symptoms with intestinal tuberculosis, which remains common in India. Distinguishing Crohn’s disease from intestinal TB can sometimes be extremely challenging, even for experienced doctors.

As a result, some patients are unnecessarily started on anti-tubercular therapy while their actual disease continues to progress silently.

Another important issue is stigma. Many patients hesitate to discuss bowel-related symptoms openly due to embarrassment. Young individuals, especially, may ignore rectal bleeding or chronic diarrhea for months, assuming it is temporary or stress-related. Social media misinformation and self-medication further worsen the problem.

When Should You Seek Medical Attention?

The good news is that treatment options for IBD have improved tremendously. Modern therapies, including biologic medications, advanced endoscopy, nutritional therapy, and personalized treatment strategies, now allow many patients to live completely normal and productive lives. Early diagnosis is the key.

Persistent bowel symptoms lasting more than a few weeks should never be ignored, especially if associated with bleeding, weight loss, anemia, or nighttime symptoms.

India urgently needs greater public awareness about IBD. Equally important is timely referral to gastroenterologists and access to proper diagnostic facilities such as colonoscopy, imaging, and histopathology. IBD is not merely a stomach problem — it is a lifelong immune-mediated disease that requires understanding, long-term care, and compassionate management.

A few months ago, a successful 36-year-old corporate executive sat across from me and said, “Doctor, I thought I had time. Nobody told me fertility could decline this fast.” A week later, I met a 27-year-old woman with severe PCOS who assumed she would face infertility in the future, when in reality, early intervention could significantly improve her chances of natural conception.

These conversations have become increasingly common in my practice and reflect an important reality: women today are more educated, financially independent, and health-conscious than ever before, yet fertility awareness remains surprisingly low. Fertility challenges in India are hard on the couple, especially on the woman, sadly, because of family expectations, interference, unconscious and conscious biases, and social stigma.

Infertility: A Growing Concern

Globally, infertility affects nearly one in six people during their reproductive years. In India alone, an estimated 15–20 million couples struggle with infertility. Studies suggest that infertility prevalence in India ranges between 4% and 17%, with urban areas showing a steady rise. Delayed marriages, late pregnancies, stress, obesity, sedentary lifestyles, environmental pollution, and hormonal disorders such as PCOS are major contributors.

One of the biggest misconceptions women have is that fertility remains stable until menopause. Biologically, this is simply not true. Female fertility peaks during the 20s. A healthy woman in her twenties has roughly a 25–30% chance of conceiving each month naturally.

By the early thirties, this falls to around 20%, and after the age of 35, fertility declines more rapidly because both the number and quality of eggs decrease significantly. By the age of 40, the monthly chance of natural conception may drop below 10%.

Understanding Ovarian Reserve

Unlike men, women are born with all the eggs they will ever have. As age advances, ovarian reserve naturally diminishes. This decline cannot be reversed by fitness, good looks, supplements, or expensive wellness treatments. While healthy living certainly improves reproductive health, it cannot stop the biological aging of the ovaries.

In modern India, many women are delaying pregnancy due to career aspirations, financial planning, late marriages, or simply the desire to achieve personal goals first. While these are valid choices, fertility awareness must become part of those decisions. Assisted reproductive technologies such as IVF have created a perception that pregnancy can be achieved at any age. However, even IVF success rates decline significantly with advancing maternal age because egg quality remains the most critical factor.

How Lifestyle Choices Affect Fertility

Lifestyle has emerged as a major fertility influencer. Smoking, vaping, obesity, excessive alcohol intake, poor sleep, chronic stress, and lack of physical activity negatively affect reproductive health. Environmental toxins deserve special attention. Exposure to plastics, pesticides, industrial pollutants, and endocrine-disrupting chemicals is increasingly being linked to declining fertility in both men and women. Fertility specialists across India are also reporting

worsening sperm quality, highlighting that infertility is not solely a female issue. Male factors contribute to nearly 40–50% of infertility cases.

The encouraging news is that timely lifestyle changes can make a meaningful difference. Maintaining a healthy weight, exercising regularly, consuming a balanced diet, reducing processed foods, improving sleep quality, and managing stress through yoga or mindfulness can support fertility and overall reproductive health.

Why Early Fertility Testing Matters

Women should also become proactive about fertility assessment. Simple investigations such as Anti-Müllerian Hormone (AMH) testing, pelvic ultrasound for ovarian reserve, thyroid evaluation, vitamin D levels, and screening for PCOS can provide valuable information. A semen analysis for the male partner remains an essential component of infertility evaluation.

So when should a woman seek medical help? Women below 35 should consult a fertility specialist if pregnancy has not occurred after one year of regular unprotected intercourse. For women above 35, evaluation should begin after six months. Immediate consultation is advisable for women with irregular periods, endometriosis, PCOS, recurrent miscarriages, pelvic infections, or a family history of early menopause. There is a possibility of preserving eggs or embryos for women and couples who do not want to get pregnant before the age of 34 years. But that also needs to be done in a timely manner.

Pregnancy After 35: Understanding the Risks

Pregnancy after 35 is increasingly common and often successful, but it carries higher risks. These include miscarriage, gestational diabetes, hypertension, chromosomal abnormalities such as Down syndrome, preterm birth, and a greater likelihood of cesarean delivery. Fortunately, with early prenatal care and appropriate monitoring, most women can still achieve healthy pregnancy outcomes.

The most important message I would like every young woman to understand is this: fertility is not just about becoming pregnant—it is about understanding your reproductive timeline before biology begins making decisions on your behalf. Women today plan their education, careers, finances, and investments meticulously. Fertility deserves the same foresight.

Awareness in your twenties may protect your choices in your thirties. In reproductive health, knowledge is not just for power but also for exploring possibilities and making the right decisions.

When a woman who maintains a healthy lifestyle, exercises regularly, follows a balanced diet, and never skips her annual health screenings, but is still diagnosed with breast cancer, it sends shockwaves far beyond her personal circle.

Each such case, particularly when it involves a celebrity or influencer, often sparks anxiety and a flood of questions for oncologists, with one concern standing out above all: if someone so health-conscious can develop breast cancer, is anyone truly safe?

The fear is natural. Yet, doctors consistently emphasize that regular screening, timely medical attention, and early detection remain the strongest tools in successfully treating breast cancer and helping patients lead healthy, cancer-free lives.

Can a Healthy Lifestyle Guarantee Protection?

Science does not have a precise answer for who is immune to breast cancer and who is not. What we do know is that a healthy lifestyle and consistent monitoring lower risk and improve outcomes compared to those who discover the condition at Stage 2 or beyond.

Women deal with a myriad of hormone-related issues. When combined with BRCA1 and BRCA2 gene mutations, inherited genetic changes that significantly raise the risk of breast and ovarian cancers, and external environmental factors, the likelihood of breast cancer incidence increases.

There is a caveat. The proactiveness of health-conscious individuals helps keep many hormonal issues in check. Which means, when cancer does develop, it is more likely to be detected early, enabling better treatment and improved clinical outcomes.

When Did You Last Examine Yourself?

This is for every woman over 20; if you spend 10 minutes once a month for self-examination, it can go a long way in catching a major risk early.

Examine your breasts a few days after your period, feeling for any lump or thickness in the breast or underarm area. Use a mirror to check for changes in size, shape, contour, skin redness, or dimpling. Persistent pain beyond your period, nipple inversion, soreness, or discharge are signs to take the next step: a mammogram and specialist consultation.

Mammogram Is A Non-Negotiable

Mammograms use X-rays to detect even the tiniest growths, and the frequency of the test depends on age and risk factors.

The first segment is those between the ages of 40 - 49: In most cases, women up to the age of 50 are recommended annual tests, but it is critical for those with dense breast tissue or a family history of breast cancer. Discuss with your doctor if you require a bi-annual mammogram.

The second category is between the ages of 50 - 75, and annual mammograms are a nonnegotiable. Given the higher incidence, Bi-annual tests are increasingly being advised by specialists.

The third segment is the High-risk category with detected BRCA mutation, family history, and prior breast biopsies. Screening for this segment begins around 30 and may include MRI alongside mammography and a personalized screening plan considering the criticality.

Hidden Threats in Everyday Life

Urban living brings a certain level of carcinogenic exposure through smoking, chemicals in food and cosmetics, air pollution, and industrial toxins, all of which elevate the risk. Chronic stress, an output of corporate and city life, compounds the burden further. This is precisely where being healthy and fit matters most. Conscious lifestyle choices help women respond to the condition better than those without them.

Bringing in a change, however, requires a domino effect; one woman who gets screened encourages another, and slowly a larger community begins to speak openly about cancer, ask questions, and seek answers without fear of judgment.

The discomfort of a mammogram lasts only seconds. The consequences of a late-stage diagnosis last far longer.