People receiving weight-loss drug Wegovy sustained weight loss for up to four years, shedding an average of 10% of their body weight in that time, as per a new study. Wegrovy is a brand that markets semaglutide injections, that have gained widespread attention for their weight-loss effects. The study also found that Semaglutide injections boost an individual's heart health, even when weight loss doesn't take place.

The study, called SELECT, was published in journal Nature Medicine. "At four years, we see ongoing benefits of semaglutide," said Cheng-Han Chen, MD, interventional cardiologist from Cardiologist, who was not involved in the research. Besides the weight loss, it also lead to a loss in cardiovascular outcomes.

The research was conducted on 17000 adults, who had obesity but did not have diabetes. Overall, people who received once-weekly injections of semaglutide lost on average 10.2% of their body weight over the course of four years. All of the study participants continued to lose weight for about 65 weeks, a year and three months, and then their weight remained at a stable level.

Were There Any Side Effects?

What Did The Results Say?

Of the people on the highest dose of Wegovy, 68% lost at least 5% of their body weight. This compared to 21% of people on the placebo. Additionally, of the total people on Wegovy about 23% lost at least 15% of their body weight. For those in the placebo group, only 1.7% lost that much body weight.

Semaglutide Shows Heart Benefits Beyond Weight Loss

Researchers found that even individuals who did not experience significant weight reduction while on the drug saw a reduced risk of major heart events. Recent analysis of the SELECT trial data revealed that semaglutide significantly lowers the risk of heart attack, stroke, and cardiovascular-related deaths in adults with obesity or those who are overweight. Notably, the results of this study lead the US FDA to approve Novo Nordisk's Wegovy for reducing heart-related risks in this group.

What Is Semaglutide?

Are Their Any Side Effects Of Semaglutide?

Semaglutide, marketed under the brand name Wegovy, is primarily an antidiabetic medication used to treat Type 2 diabetes. It is also an anti-obesity drug used for long-term weight management. While it can be taken as a subcutaneous injection or orally, it has significant side effects. It primarily impacts your gastrointestinal tract and its side effects include constipation, nausea, abdominal pain, diarrhoea, and fatigue amongst others.

Prateek Yadav (38), the son of late Samajwadi Party founder Mulayam Singh Yadav, died due to a massive blockage in the blood vessels of the lungs, leading to a collapse of the heart and respiratory system, as revealed in the postmortem examination report.

According to the autopsy findings, the provisional cause of death was recorded as “cardiorespiratory collapse due to massive pulmonary thromboembolism.” In simple terms, doctors said a large blood clot had blocked blood flow to the lungs, causing his heart and breathing to fail.

What Is Pulmonary Thromboembolism?

An embolism is any object (clot, fat, air, tissue) traveling through the bloodstream that becomes stuck, blocking blood flow. A thromboembolism is a specific type of embolism where that travelling object is a piece of a blood clot (thrombus) that has broken off from its original site.

It is a life-threatening condition that happens when a blood vessel in the lungs is blocked by a blood clot.

The common symptoms may include:

• Difficulty in breathing
• Chest pain
• Cough up blood

The blood clot starts in a deep vein in the leg and travels to the lung in most cases. Rarely, the clot forms in a vein in another part of the body, noted Mayo Clinic. When a blood clot forms in one or more of the deep veins in the body, it is called a deep vein thrombosis or DVT.

Other symptoms of pulmonary embolism include:

• irregular heartbeat
• lightheadedness or dizziness
• excessive sweating
• fever
• leg pain or swelling, usually in the back of the lower leg
• clammy or discolored skin

Also read: Your Desk Jobs May Impact Fertility, Not Just Waistlines, Say Experts

Lung Infection Claims Life of Karnataka Minister

Meanwhile, Karnataka's Planning and Statistics Minister, D. Sudhakar (66), passed away after a prolonged battle with a lung infection.

The most common lung infections that people experience are pneumonia, bronchitis, tuberculosis, influenza-related infections, and severe viral illnesses.

Experts noted that these lung infections cause fluid or pus to fill the air sacs, which prevents oxygen from entering the bloodstream.

"What may initially appear as a routine cough, fever, or chest infection can progress to severe pneumonia, respiratory failure, sepsis, or permanent lung damage,” Dr. Vikas Mittal, Director - Pulmonologist, CK Birla Hospital, Delhi, told HealthandMe.

Warning signs include

• worsening breathlessness,
• persistent fever,
• chest pain,
• bluish lips,
• confusion,
• falling oxygen levels should never be ignored.

Dr. Nikhil Rajvanshi, Consultant - Paediatric Pulmonology, Rainbow Hospital, Delhi, told HealthandMe that children may be more at risk of pulmonary infections as they can become dangerous quickly because their lungs and immune systems are still developing.

Common illnesses such as bronchiolitis, pneumonia, influenza, and other viral infections may rapidly lead to breathing difficulty, low oxygen levels, dehydration, and respiratory distress. Infants, premature babies, malnourished children, and those with asthma or congenital disorders are at higher risk of complications.

The experts called for

• early medical evaluation
• timely treatment
• vaccination
• good hygiene practices,
• quit smoking,
• maintaining immunity.

US President Donald Trump's attempt to clarify the meaning of "sea" while discussing drug smuggling has again raised concerns of dementia.

While the 79-year-old President rambled between “sea and see” in the middle of discussing drug problems in the US, social media went rife with the rumor of his cognitive decline.

"Drugs coming by sea meaning coming by water. A lot of people don’t know what I mean by sea. They think I mean vision. I’m talking about sea like the sea," he said. He was speaking at the White House, while hosting law enforcement officials for a dinner in the Rose Garden in celebration of National Police Week.

His comments were called out by social media as his apparently worsening cognitive capabilities.

"When he says 'a lot of people' he means 'me.' His cognitive issues are a crisis," one social media user declared, while another admitted, "He’s getting worse."

Trump has spoken on sea and see, during a maternal healthcare event last week, where he also referred to himself as the “father of fertility.”

Earlier, speaking at the White House Small Business Summit, Trump said he has taken the Montreal Cognitive Assessment three times and “aced each one,” claiming a doctor told him it was the first time they had seen a perfect score, The Daily Beast reported.

The US President said he answered the test questions easily, suggesting he is cognitively in good condition—a claim that critics have repeatedly questioned.

“The first question is very easy,” he said. “You have a lion, a bear, an alligator, and a—what’s another good…? A squirrel. Which is the squirrel?” He added that the difficulty increases as the test progresses. “By the time you get to the middle, they’re very tough.”

However, the test’s creator, Canadian neurologist Ziad Nasreddine, has challenged Trump’s claims. “It wasn’t designed to be a test of IQ,” he told nine.com.au. “It was designed to assess normal cognitive performance.”

Experts Claim Trump's Mental Health Is Deteriorating

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A group of medical experts, including neurologists, psychiatrists, and other physicians, has sounded the alarm over what they’ve described as Trump’s deteriorating mental health.

The experts have not specifically examined Trump face-to-face. But, they analyzed Trump's statements and behaviors over the past year, and stated that he’s “mentally unfit” and must be removed from office “with the greatest urgency” amid the escalating tension around the world, according to their statement published in The BMJ.

“It is our professional opinion that they (Trump's statements) reflect a rapidly worsening, reality-untethered, increasingly dangerous decline,” the experts said.

They also listed some of Trump’s observable serious medical issues, such as “Marked deterioration in cognitive functioning, evidenced by disorganized and tangential speech, rambling digressions, factual confusions, unexplained sudden changes of course in strategic matters, both national and international, episodes of apparent somnolence during critical public proceedings.”

Read More:PCOD vs PCOS vs PMOS: Why The Condition’s Name Has Changed Over Time

What The White House Says

The White House has continued to say that Trump remains in strong health.

In October 2025, White House physician Captain Sean Barbabella said the president “continues to demonstrate excellent overall health,” AOl.com reported.

"President Trump’s sharpness, unmatched energy, and historic accessibility stand in stark contrast to what we saw during the last administration when Democrats and other lunatics intentionally covered up Joe Biden’s serious mental and physical decline from the American people,” White House spokesman Davis Ingle was quoted as saying to The Daily Beast.

From Polycystic Ovarian Disease (PCOD) to Polycystic Ovary Syndrome (PCOS) and now Polyendocrine Metabolic Ovarian Syndrome (PMOS) — confused about what the changing terminology means for women’s health and treatment?

What was once seen mainly as a reproductive or ovarian disorder is now being recognized as a complex hormonal and metabolic condition that can affect everything from periods and fertility to weight, insulin resistance, heart health, skin, and mental well-being.

To better understand the distinction between the three, let’s look at how the condition has evolved.

The condition, involving irregular periods, infertility, excess facial hair, and enlarged ovaries containing multiple cysts, was first identified as an ovarian or reproductive disorder in the 1930s by American gynecologists Dr. Irving Stein and Dr. Michael Leventhal. It became known as Stein-Leventhal Syndrome.

Over the years, the term PCOD became widely used, especially in countries like India. The name focused mainly on the presence of multiple ovarian cysts seen on ultrasound scans. It was considered a “disease” affecting ovulation and fertility.

Further, in the 1980s and 1990s, experts discovered that the condition involved hormonal imbalances, insulin resistance, weight gain, diabetes risk, and heart health concerns, among others.

Because it affected multiple body systems, PCOS became the medically preferred global term. The word “syndrome” was used to describe a group of related symptoms rather than a single disease.

However, many experts argued that the name still overemphasized ovarian cysts and fertility, and in 2012, the US National Institutes of Health (NIH) officially recommended changing the name, saying it was misleading because:

• Not all women with the condition have cysts
• Ovarian cysts alone are not enough for diagnosis
• The name ignores the metabolic and hormonal aspects

In 2026, global experts publishing in The Lancet proposed the new name -- PMOS – for the condition affecting more than 170 million women worldwide.

The new term PMOS acknowledges that the condition involves:

• Endocrine health
• Metabolic health
• Reproductive health
• Dermatological health
• Psychological health.

What Does PMOS Mean?

Also read: PCOS Is Now PMOS: What The Name Change Means For Millions Of Women

The new name aims to explain the condition more accurately and comprehensively.

Polyendocrine means it affects multiple hormones in the body.

Metabolic refers to issues linked to weight, insulin, blood sugar, and heart health.

Ovarian highlights its impact on ovulation and reproductive health.

Syndrome refers to a group of symptoms occurring together.

In simple terms, PMOS is a hormonal and metabolic condition that can affect periods, fertility, skin, mood, weight, and long-term health.

What The Name Change Means For Women

Speaking to HealthandMe, Dr Monika Bhatia Director — Obstetrics & Gynaecology Robotic and Laparoscopic Surgeon Cloudnine Group of Hospitals, said that the earlier name was misleading because the "cysts" in PCOS are not real cysts — they are simply small, arrested follicles.

While the name has changed, the message remains the same.

“Behind every diagnosis is a woman trying to understand her body, hormones, emotions, and health. While this condition may affect periods, fertility, metabolism, skin, weight, or mental well-being differently, one thing remains common — it is manageable with the right guidance,” she said.

The core treatment stays the same as the guidelines for treatment have not changed, but the approach becomes wider.

“So instead of just treating the periods, PMOS is now managed as a whole-body condition involving a multidisciplinary team”.

Will there be any change to evaluation?

Dr Muskaan Chhabra, Fertility Specialist, Birla Fertility & IVF, Lajpat Nagar, told HealthandMe that the new name –PMOS- correctly acknowledges that this is a multisystem condition involving complex interactions between insulin, androgens, and neuroendocrine hormones.

In PMOS, the ovaries are one of several systems involved rather than the primary site of the problem.

This “opens the door to more comprehensive clinical evaluation, earlier and more accurate diagnosis, and treatment approaches that address the full hormonal and metabolic picture rather than a narrow reproductive one,” Dr Muskaan said. It will also “drive more integrated and personalized care”.