People receiving weight-loss drug Wegovy sustained weight loss for up to four years, shedding an average of 10% of their body weight in that time, as per a new study. Wegrovy is a brand that markets semaglutide injections, that have gained widespread attention for their weight-loss effects. The study also found that Semaglutide injections boost an individual's heart health, even when weight loss doesn't take place.

The study, called SELECT, was published in journal Nature Medicine. "At four years, we see ongoing benefits of semaglutide," said Cheng-Han Chen, MD, interventional cardiologist from Cardiologist, who was not involved in the research. Besides the weight loss, it also lead to a loss in cardiovascular outcomes.

The research was conducted on 17000 adults, who had obesity but did not have diabetes. Overall, people who received once-weekly injections of semaglutide lost on average 10.2% of their body weight over the course of four years. All of the study participants continued to lose weight for about 65 weeks, a year and three months, and then their weight remained at a stable level.

Were There Any Side Effects?

What Did The Results Say?

Of the people on the highest dose of Wegovy, 68% lost at least 5% of their body weight. This compared to 21% of people on the placebo. Additionally, of the total people on Wegovy about 23% lost at least 15% of their body weight. For those in the placebo group, only 1.7% lost that much body weight.

Semaglutide Shows Heart Benefits Beyond Weight Loss

Researchers found that even individuals who did not experience significant weight reduction while on the drug saw a reduced risk of major heart events. Recent analysis of the SELECT trial data revealed that semaglutide significantly lowers the risk of heart attack, stroke, and cardiovascular-related deaths in adults with obesity or those who are overweight. Notably, the results of this study lead the US FDA to approve Novo Nordisk's Wegovy for reducing heart-related risks in this group.

What Is Semaglutide?

Are Their Any Side Effects Of Semaglutide?

Semaglutide, marketed under the brand name Wegovy, is primarily an antidiabetic medication used to treat Type 2 diabetes. It is also an anti-obesity drug used for long-term weight management. While it can be taken as a subcutaneous injection or orally, it has significant side effects. It primarily impacts your gastrointestinal tract and its side effects include constipation, nausea, abdominal pain, diarrhoea, and fatigue amongst others.

Brain health is often associated with old age, but according to neurologists, the foundation for healthy cognitive function is laid much earlier.

On World Brain Day, they warned that the 30s and 40s are a crucial period to protect the brain, as lifestyle habits and underlying health conditions can quietly affect memory, concentration, and overall cognitive health.

Brain Ages Alongside the Heart

Speaking to HealthandMe, Dr. Gurucharan Adoor, Neurologist, Apollo Hospitals Bannerghatta Road, Bengaluru, said brain health is closely linked to cardiovascular health. High blood pressure, high cholesterol, and elevated blood sugar can silently damage the brain years before noticeable symptoms appear.

His advice? Make preventive health checks a routine by monitoring blood pressure, blood glucose or HbA1c, cholesterol, weight, and waist circumference—especially for people with a family history of diabetes, stroke, or early heart disease.

Brain Fog A Warning Signal

Also read: Neurological Disorders Emerging As India's Next Major Public Health Challenge, Say Experts

Dr. Adoor said sleep is often the first thing people sacrifice during their busiest years, but the brain pays the price.

Irregular sleep schedules, untreated sleep apnea, and repeated nights of poor-quality sleep can lead to mental fatigue, difficulty concentrating, and persistent brain fog. If brain fog continues, he said, it should not be ignored, as it may indicate an underlying health issue that requires attention.

Dr. Bhushan Joshi, Consultant Neurologist, Manipal Hospital, Kharadi, Pune, told HealthandMe that he is "seeing more professionals in their 30s and 40s complaining of brain fog than ever before". According to him, hormonal changes and chronic inflammation are among the common but often overlooked causes.

Hormonal Changes Can Affect Cognitive Function

Dr. Joshi noted that hormonal fluctuations can significantly influence brain function. Women entering perimenopause may experience difficulty concentrating, while others may notice "word retrieval and short-term memory due to changing estrogen levels that influence brain function."

He added that it is not limited to women. Men also undergo age-related hormonal changes that can affect energy levels and cognitive performance. While these changes are often temporary, they can still be distressing.

Read More: Aspartame, Saccharin, Erythritol Linked To Faster Brain Ageing: Study

Chronic Inflammation May Reduce Mental Clarity

Dr. Joshi explained that chronic low-grade inflammation can also contribute to brain fog. Conditions such as obesity, diabetes, autoimmune diseases, and persistent infections can trigger inflammatory responses that interfere with the brain's ability to process information efficiently. In some people, inflammation has been linked to reduced attention, poor memory, and diminished mental clarity.

Small Lifestyle Changes Key

The good news: Simple daily habits can support long-term brain health. Regular physical activity—whether it's walking, cycling, dancing, or strength training several times a week—improves blood flow to the brain, boosts mood, and supports healthy ageing.

Dr. Adoor also recommends limiting unnecessary screen time, taking regular breaks from phones and digital devices, and focusing on one task at a time to reduce mental overload.

When Should You See A Doctor?

Occasionally feeling mentally sluggish is common, but worsening memory problems or cognitive changes that begin interfering with work or daily life should not be ignored, Dr. Joshi said.

He added that these symptoms may stem from treatable conditions such as thyroid disorders, vitamin deficiencies, anxiety, or depression, making timely medical evaluation important.

Insufficient sleep can impact the brain. A good night's sleep allows the brain to repair and even recharge. Poor sleep over time can increase the risk of several neurological disorders and affect overall brain health.

This article helps to understand how poor sleep can take a toll on neurological health. Read on to know more about this and get a sound sleep at night.

Currently, due to hectic schedules, people are now sacrificing sleep to meet work deadlines, study longer, or spend more time on screens. Missing a few hours of sleep once in 2-3 months is harmless.

However, chronic sleep deprivation can not only cause irritation and weight gain but also neurological issues. During sleep, the brain processes memories, repairs nerve cells, regulates emotions, and clears waste products that accumulate throughout the day.

When sleep is disturbed on a regular basis, there can be a risk of neurological problems over time.

How Poor Sleep Affects The Brain

Also read: The Silent Impact of Stress On Your Brain: How Chronic Stress Affects Memory, Focus, And Mental Health

If you are one of those who is unable to get a sound sleep at night, then beware. If you are a night owl, then you will have to ensure you sleep well now.

Sleep helps the brain store and organise new information. Lack of sleep can make it difficult to concentrate, learn new skills, and remember important details. Many will also experience poor decision-making.

Poor sleep, especially when associated with conditions like sleep apnoea, can increase blood pressure and reduce oxygen supply, raising the risk of stroke in the near future.

Long-term sleep deprivation may reduce the brain's ability to clear harmful proteins such as beta-amyloid, which are linked to Alzheimer's disease and other forms of dementia.

People who sleep too little or have poor-quality sleep can also suffer from constant headaches and migraine attacks. In people living with epilepsy, inadequate sleep is a common trigger for seizures. Poor sleep increases the risk of anxiety, depression, irritability, and emotional stress.

Tips For Better Brain Health Through Sleep

It is necessary to get at least 7-9 hours of sleep per day. Maintain a consistent sleep and wake-up schedule.

Avoid screens, caffeine, and heavy meals before hitting the sack. Exercise regularly but avoid intense workouts late at night.

Keep your bedroom quiet, cool, and dark so that you can sleep better. Seek help from the doctor if you snore loudly, stop breathing during sleep, or feel excessively sleepy during the day.

So, just like a balanced diet, exercise, and staying stress-free by doing yoga and meditation, getting a good night’s sleep is also important. Sleep well and prevent any neurological issues.

In today's fast-paced world, stress has become an unavoidable part of life. While short-term stress can help us stay alert and respond to challenges, prolonged or chronic stress can have a significant impact on brain health.

On the occasion of World Brain Day, it is important to raise awareness about how unmanaged stress can silently affect memory, concentration, emotional well-being, and overall quality of life.

How Chronic Stress Affects the Brain

When the body is under constant stress, it releases higher levels of cortisol, commonly known as the stress hormone. Persistently elevated cortisol can interfere with the normal functioning of the brain, particularly areas responsible for learning, memory, and decision-making.

Individuals may experience forgetfulness, difficulty concentrating, reduced productivity, irritability, anxiety, and disturbed sleep. If left unaddressed, chronic stress may also increase the risk of depression and other mental health disorders.

How to Protect Your Brain from Stress

The good news is that the brain has an incredible ability to recover when stress is managed effectively. Adopting healthy lifestyle habits such as regular physical activity, adequate sleep, mindfulness practices, balanced nutrition, and maintaining meaningful social connections can significantly reduce stress levels and protect brain function. It is equally important to recognize when stress becomes overwhelming and seek timely professional support.

Prioritize Brain Health

Brain health is just as important as heart health, and taking care of our mental well-being should never be overlooked. This World Brain Day, let us prioritize stress management as an essential part of a healthy lifestyle. By identifying the early signs of chronic stress and making positive lifestyle changes, we can preserve memory, improve focus, enhance emotional resilience, and ensure a healthier brain for years to come.