Wegovy Users Maintain Weight Loss for 4 Years: Here's How It Works

Updated Dec 3, 2024 | 09:00 PM IST

SummaryWegovy, is primarily an antidiabetic medication used to treat Type 2 diabetes. People receiving weight-loss drug Wegrovy sustained weight loss for up to four years
wegovy

wegovy (Credit: Canva)

People receiving weight-loss drug Wegovy sustained weight loss for up to four years, shedding an average of 10% of their body weight in that time, as per a new study. Wegrovy is a brand that markets semaglutide injections, that have gained widespread attention for their weight-loss effects. The study also found that Semaglutide injections boost an individual's heart health, even when weight loss doesn't take place.

The study, called SELECT, was published in journal Nature Medicine. "At four years, we see ongoing benefits of semaglutide," said Cheng-Han Chen, MD, interventional cardiologist from Cardiologist, who was not involved in the research. Besides the weight loss, it also lead to a loss in cardiovascular outcomes.

The research was conducted on 17000 adults, who had obesity but did not have diabetes. Overall, people who received once-weekly injections of semaglutide lost on average 10.2% of their body weight over the course of four years. All of the study participants continued to lose weight for about 65 weeks, a year and three months, and then their weight remained at a stable level.

Were There Any Side Effects?

However, people's experience with the medication varied. Researchers found no unexpected safety issues with drug during trial. In fact, most the people who withdrew from the study were those who experienced the known symptsoms of the semaglutide injections like nausea, indigestion etc. This occurred mainly during the beginning of the study, as the dose of the medicine is increased to a maximally tolerated dose.

What Did The Results Say?

Of the people on the highest dose of Wegovy, 68% lost at least 5% of their body weight. This compared to 21% of people on the placebo. Additionally, of the total people on Wegovy about 23% lost at least 15% of their body weight. For those in the placebo group, only 1.7% lost that much body weight.

Semaglutide Shows Heart Benefits Beyond Weight Loss

Researchers found that even individuals who did not experience significant weight reduction while on the drug saw a reduced risk of major heart events. Recent analysis of the SELECT trial data revealed that semaglutide significantly lowers the risk of heart attack, stroke, and cardiovascular-related deaths in adults with obesity or those who are overweight. Notably, the results of this study lead the US FDA to approve Novo Nordisk's Wegovy for reducing heart-related risks in this group.

What Is Semaglutide?

Semglutide is the synthetic version of GLP-1—a natural hormone produced in the intestines that regulates blood sugar, appetite, and digestion. Now, every time you eat, your body produces various hormones, including GLP-1. These are called Post nutrition hormones, and help you absorb the energy you just consumed. GLP-1 travels to your pancreas, prompting it to produce insulin. It also travels to the hypothalamus in your brain, which gives you the feeling of being full or satiated. Ozempic imitates this hormone, thereby, silencing the food chatter in the brain. Interestingly, for some people this food chatter is really quiet ( people with low appetite) and for others it is an outburst, (people who generally binge eat.) So with Ozempic, silencing this self-talk in the brain, people tend to lose their appetite and eventually weight.

Are Their Any Side Effects Of Semaglutide?

Semaglutide, marketed under the brand name Wegovy, is primarily an antidiabetic medication used to treat Type 2 diabetes. It is also an anti-obesity drug used for long-term weight management. While it can be taken as a subcutaneous injection or orally, it has significant side effects. It primarily impacts your gastrointestinal tract and its side effects include constipation, nausea, abdominal pain, diarrhoea, and fatigue amongst others.

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AI Enabling Faster And Earlier Cancer Detection In India

Updated May 20, 2026 | 01:00 PM IST

Summary​Use of AI is not without challenges: knowledge of proper tools and applications is critical. Results can not be relied upon blindly, and an expert is very critical of their analysis. Sometimes there may be an improper result that needs to be filtered out.
AI Enabling Faster And Earlier Cancer Detection In India

Credit: AI generated image

Everyone knows that when cancer is detected early, cure rates are far superior, side effects are much less, and treatment expenses are also less.

Diagnosis of cancer depends upon carrying out various tests and then their analysis to reach a conclusion.

How AI Supports Cancer Diagnosis

These tests are radiological, like Chest X-ray, CT scans, MRI, Mammography, etc., and in histopathology, analysis of tissue, be it a small biopsy, large specimen handling, or Frozen Section. AI is empowered with large data to suggest and analyze minute patterns that are difficult for a human mind to comprehend, supported by machine learning.

With the use of AI in the analysis of radiological data, it points out suspicious changes (data is fed into its memory), but they are not very clearly visible to the human eye. Hence, it alerts the radiologist to have a close look at that and enhances accuracy and reduces the chances. It is the radiologist who takes the final call because it has to be correlated with the patient’s clinical findings and other information from other investigations of the patient.

Early detection of breast cancer has received a big boost from the integration of AI in the analysis of mammography data. Similar applications are also used by pathologists when they are examining the tissues because the final diagnosis of cancer can be obtained on histopathology only.

Challenges In The Use Of AI

Use of AI is not without challenges: knowledge of proper tools and applications is critical. Results can not be relied upon blindly, and an expert is very critical of their analysis. Sometimes there may be an improper result that needs to be filtered out.

It's time to accept that AI is present and not the future, and we need to learn, adapt, and use it to the benefit of mankind. India is making great strides in AI, and many startups have also come up that are doing a great job.

The real strength of AI in the care of cancer mainly lies in its ability to support the doctors in making faster, sharper, and more well-informed decisions. It can also reduce delay in diagnostics, improve efficiency of screening, and help in detecting cancers at a stage where outcomes of treatment are much better.

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Extreme Summer Heat, Pollution Can Take A Toll On Your Eyes: Here’s How To Stay Protected

Updated May 20, 2026 | 01:35 PM IST

SummaryThe India Meteorological Department (IMD) has issued an orange alert for Delhi until May 25, cautioning residents about prolonged heatwaves and excessive heat conditions expected over six consecutive days.
Extreme Summer Heat, Pollution Can Take A Toll On Your Eyes: Here’s How To Stay Protected

Credit: AI generated image

Amid rising summer temperatures, along with pollution, eye specialists today warned that the heat and dust can add stress on the eyes, leading to dryness, allergies, infections, and irritation.

Delhi witnessed its first official heatwave day of the month on Tuesday, as scorching sunshine and dry winds pushed temperatures beyond 45°C across several parts of the city.

The India Meteorological Department (IMD) warned that conditions are likely to worsen over the coming days, with temperatures expected to rise to nearly 46°C on May 20.

The weather department has also issued an orange alert for Delhi until May 25, cautioning residents about prolonged heatwaves and excessive heat conditions expected over six consecutive days.

Allergies, Dryness, and Infections Common In Summer

Speaking to HealthandMe, Dr. Bhavatharini M, Senior Consultant Ophthalmologist at Dr. Agarwal's Eye Hospital, said that summer conditions can significantly impact eye health.

“Summer places added stress on the eyes, particularly in cities like New Delhi where heat, dust, and pollution are significant factors,” she said.

Dr. Bhavatharini explained that common concerns during the season include dryness caused by increased tear evaporation while

  • watching screens,
  • allergies triggered by environmental irritants,
  • UV-related damage,
  • infections linked to swimming in poorly maintained pools.
Also read: What Is Favipiravir? COVID-Era Antiviral Now Used In Hantavirus Response In UK

Dr. Kalpana R, Senior Consultant, Ophthalmology at SIMS Hospital, also warned of problems that affect the eyes during this season, such as

  • allergies,
  • dryness,
  • seasonal infections,
  • viral and bacterial infections,
  • swimming pool infections,
  • migraine headaches.

She stressed the importance of maintaining proper hydration and following a balanced, nutritious diet to support eye health during the hotter months.

How To Prevent Eye Health In Scorching Summers

Dr. Bhavatharini advised people to take simple preventive measures, such as wearing UV-protective sunglasses, staying well-hydrated, avoiding rubbing their eyes, and using protective goggles while swimming.

“Persistent redness, irritation, or blurred vision should not be ignored and warrants timely evaluation by your eye specialist,” she added.

Dr. Kalpana further recommended wearing protective eyewear outdoors to shield the eyes from harmful UV rays and glare.

People travelling on bikes should wear helmets with visors to reduce exposure to dust and pollution, while swimmers should use swimming goggles to prevent infections and injuries associated with pool water.

For allergies, she advised people not to rub their eyes even if they experience itching.

“Just as a home remedy, you can use an ice pack over the closed eyelids or splash cold water over the closed eyelids to get some immediate relief,” she told HealthandMe.

Avoid Self-Medication

The experts also warned against self-medication in case of eye infections.

“And for viral infections and bacterial infections, if you feel that you get a sticky discharge and redness, you must immediately go to an ophthalmologist and get it treated. Never use over-the-counter medicines for any of your infections,” Dr. Kalpana said.

She added that people with common cold symptoms should wear masks and avoid touching commonly used surfaces if they have signs of an eye infection, as infections can spread through secretions.

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Kim Kardashian Says She Takes 35 Supplements Daily, Suffers From 'Pill Fatigue'

Updated May 20, 2026 | 10:06 AM IST

Summary The 45-year-old reality star Kim Kardashian revealed that her family, including her mother, Kris Jenner, and sisters, regularly use DEXA scans to monitor bone density.
Kim Kardashian Says She Takes 35 Supplements Daily, Suffers From 'Pill Fatigue'

Credit: Kim Kardashian/X

American TV personality Kim Kardashian has opened up about the steps she takes to care for her health, including taking 35 supplements daily.

Speaking on a podcast, the 45-year-old mother admitted she suffers from “pill fatigue.”

“I take probably 35 supplements a day,” the reality star revealed. “I spread them out three times a day.”

The mother of four said she struggles particularly with fish oil supplements because of their lingering taste, and even wished there were an IV drip alternative available.

“I thought, ‘Okay, I can't do this fish oil anymore. I have pill fatigue. I have to stop these fish oil [supplements], and I got my bloodwork, and it was so evident that I stopped and I had to start again,” Kim said.

“I wish there was like an IV drip (for fish oil) I could do every day, and I would just do it on my way to work,” she added.

Kardashian Family Uses DEXA Scans

Also read: Amy Schumer Opens Up On Side Effects After “Botched” Colonoscopy And Weight Loss Journey

Further, Kim revealed that her family, including her mother, Kris Jenner, and sisters, regularly use DEXA scans to monitor bone density.

A DEXA scan (Dual-Energy X-ray Absorptiometry) is an imaging test that uses low-frequency X-rays to measure bone density and analyze total body composition, including lean muscle, fat mass, and visceral fat.

“I actually know a portable DEXA scan person that comes in a van, and you lie down,” she shared.

“Each one of my sisters and my mom — we all live in the same gated community — so we have the van drive by, and we all jump in the van, and you just lie down, and it scans your body maybe like three minutes. And it tells you all about your bone density.”

Kardashian also said she undergoes yearly scans with her family and is continuing to explore new wellness tools.

Kim's Diagnosis With Brain Aneurysm

Kim has also been diligent about monitoring her health in recent years. In a November 2025 episode of The Kardashians, she revealed that doctors had discovered a small aneurysm in her brain.

At the time, Kim explained that the aneurysm — a balloon-like bulge in a blood vessel in the brain — could be linked to the stress she had experienced over the years. She said her divorce from Kanye West, the responsibilities of being a single mother of four, her multiple business ventures, and studying law had all contributed to immense stress.

Shortly before that episode aired, Kim also discussed the aneurysm during an appearance on Good Morning America.

“It's just a good measure to go; make sure that you always check everything,” Kim said. “Health is wealth, and you just have to be careful with everything that you do.”

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