People receiving weight-loss drug Wegovy sustained weight loss for up to four years, shedding an average of 10% of their body weight in that time, as per a new study. Wegrovy is a brand that markets semaglutide injections, that have gained widespread attention for their weight-loss effects. The study also found that Semaglutide injections boost an individual's heart health, even when weight loss doesn't take place.

The study, called SELECT, was published in journal Nature Medicine. "At four years, we see ongoing benefits of semaglutide," said Cheng-Han Chen, MD, interventional cardiologist from Cardiologist, who was not involved in the research. Besides the weight loss, it also lead to a loss in cardiovascular outcomes.

The research was conducted on 17000 adults, who had obesity but did not have diabetes. Overall, people who received once-weekly injections of semaglutide lost on average 10.2% of their body weight over the course of four years. All of the study participants continued to lose weight for about 65 weeks, a year and three months, and then their weight remained at a stable level.

Were There Any Side Effects?

What Did The Results Say?

Of the people on the highest dose of Wegovy, 68% lost at least 5% of their body weight. This compared to 21% of people on the placebo. Additionally, of the total people on Wegovy about 23% lost at least 15% of their body weight. For those in the placebo group, only 1.7% lost that much body weight.

Semaglutide Shows Heart Benefits Beyond Weight Loss

Researchers found that even individuals who did not experience significant weight reduction while on the drug saw a reduced risk of major heart events. Recent analysis of the SELECT trial data revealed that semaglutide significantly lowers the risk of heart attack, stroke, and cardiovascular-related deaths in adults with obesity or those who are overweight. Notably, the results of this study lead the US FDA to approve Novo Nordisk's Wegovy for reducing heart-related risks in this group.

What Is Semaglutide?

Are Their Any Side Effects Of Semaglutide?

Semaglutide, marketed under the brand name Wegovy, is primarily an antidiabetic medication used to treat Type 2 diabetes. It is also an anti-obesity drug used for long-term weight management. While it can be taken as a subcutaneous injection or orally, it has significant side effects. It primarily impacts your gastrointestinal tract and its side effects include constipation, nausea, abdominal pain, diarrhoea, and fatigue amongst others.

Skin breakouts are often common occurrences during the monsoon season, but not all outbreaks of bumps that occur during this period are traditional cases of acne.

The combination of humidity along with sweat and sebum production makes the skin susceptible to different skin conditions, making it easy to mistake fungal acne for a regular one.

While acne and fungal acne may appear almost identical, the factors that trigger them are not the same. Identifying the right condition early makes it easier to choose the most appropriate treatment and maintain healthier skin in the long run.

How Monsoon Weather Triggers Different Breakouts?

It is quite common to experience frequent breakouts during monsoon season. This usually happens due to the accumulation of humid conditions, sweat, and increased oil production.

When sweat mixes with sebum, dead skin cells and skincare products, pores may become clogged, which eventually results in acne. At the same time, the environment also supports the growth of Malassezia, a yeast that naturally lives on the skin.

When it grows excessively, it can trigger fungal acne, medically known as Malassezia folliculitis. Since both conditions tend to flare up during the rainy season, they are frequently confused with one another.

Also read: Besides Sunscreen, What Everyday Habits Can Help Reduce Sun Exposure And Skin Damage?

Acne vs. Fungal Acne: A Closer Look at the Differences

There are several indications which one may use to differentiate between normal acne and fungal acne. Regular acne mostly develops as a combination of blackheads, whiteheads, inflamed pimples, and sometimes painful cysts.

On the other hand, fungal acne presents itself in the form of tiny bumps that usually appear itchy and develop in clusters. These bumps commonly occur on the forehead, chest, shoulders and upper back, especially in areas where sweat tends to collect.

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Choosing the Right Treatment Path

Since regular acne and fungal acne occur due to different reasons, they also require different treatment approaches. Although proper skin care can help in reducing the possibilities of outbreaks, it does not entirely prevent breakouts.

Over-the-counter acne products are usually intended to unclog the pores and control the growth of bacteria causing acne; however, they do not work on fungal infections. In fact, in some cases, using the wrong products can even worsen irritation or allow the breakouts to persist.

Therefore, always consult a dermatologist for targeted skin issues, particularly when acne scars are also a concern. In such situations, many experts may suggest modern treatments such as Harmony XL Pro for personalised results.

This multi-application platform combines numerous energy-based technologies to address specific acne-related concerns and is also used in a variety of aesthetic procedures such as acne-scar removal and overall skin rejuvenation.

Small Changes That Support Healthier Skin

A minimal skincare routine can go a long way during the monsoon. Always start with a gentle cleansing after excessive sweating. Choose non-comedogenic moisturisers and make sure not to apply multiple oily or occlusive products that could result in clogged pores.

If you develop a breakout, do not pick or squeeze the acne, as doing so can increase inflammation and the risk of scarring.

In the end, recognising whether a breakout is regular acne or a fungal one is the first step towards appropriate treatment. Although both conditions become more common during humid weather, they are not managed in the same way.

Paying attention to symptoms such as itching, the pattern of the bumps and how the skin responds to treatment can make a meaningful difference.

By Dr. Anwesha Poddar, Dermatologist, Dr. Anwesha Poddar Skin, Laser & Hair Clinic

People think of menopause as just hot flashes and irregular periods, but menopause is more than that.

Perimenopause and menopause can bring a host of emotional and cognitive shifts for many women, including mood swings, anxiety, easily irritated, trouble sleeping, or having what some refer to as “brain fog.”

What Is Perimenopause?

Perimenopause is the period leading up to menopause that can last anywhere from two to eight years. This is when hormonal changes take place, especially a drop in estrogen.

These hormonal changes also impact neurotransmitters like serotonin and dopamine that are essential for mood, memory, sleep and emotional wellness.

Consequently, a woman can suffer from forgetfulness, lack of concentration, mental tiredness, low energy levels, dry skin, loss of libido and less productivity.

Brain Fog During Menopause

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Brain fog can be a frustrating and overwhelming experience during menopause, particularly if a woman is juggling her career, family, ageing parents and personal obligations.

Many women suffer from anxiety symptoms, even if they have no mental health background. Hormonal changes, poor sleep and stress can exacerbate these symptoms.

But not all symptoms are due to the menopause or "normal ageing". Thyroid disorders, vitamin deficiencies, depression and other medical problems can have similar symptoms.

Therefore, if symptoms start to impact life, work, relationships or emotional wellbeing, it is important to seek medical advice and have a proper health check-up.

How To Manage It?

Management is often comprehensive, and may involve lifestyle modifications. Regular exercise, balanced nutrition, stress management and healthy sleep patterns.

In a few instances, you may additionally be suggested to take Menopausal Hormone Therapy (MHT). As more research is done and preparations of lower doses and greater safety, earlier misconceptions about hormone therapy are gradually decreasing.

Medically, women can make a difference in their quality of lives and manage menopause with greater physical, mental and emotional wellness with early recognition and timely intervention.

By Dr. Nidhi Sharma Chauhan, Gynaecologist, Saifee Hospital

Everyone knows that using sunscreen is one of the most important steps for protecting the skin from harmful sun rays, but dermatologists explain that it isn't the only thing you should do to keep your skin healthy. Other daily routines are also important for minimizing sun damage and maintaining healthy skin over time.

Protecting The Skin Barrier

Skin is a protective barrier for the body but constant exposure to the sun, pollution, heat and unhealthy lifestyle habits can make this barrier vulnerable.

Once the skin barrier is damaged, the skin is more susceptible to tanning, pigmentation, dryness, sun ageing and other sun damage.

Moisturising Supports Skin Health

Using a moisturiser every day is a very simple, yet effective habit. A good moisturiser is one that doesn't contain any scents and will support the barrier function of the skin, thereby preventing unwanted water loss from the skin.

Wet and plump skin is resistant to the environment and sun's rays.

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Antioxidants Help Fight Sun Damage

Antioxidants are also a best practice for dermatologists. Antioxidants prevent the damage to skin cells by free radicals created by UV exposure, pollution etc.

This protection can help minimize issues like hyperpigmentation, uneven skin tone and premature ageing. Consuming foods that contain antioxidants (such as fruits, vegetables and nuts) can help keep skin healthy on the inside.

Stay Hydrated For Healthier Skin

Next, hydration is crucial. It's important to keep drinking enough water all day long to keep the skin supple and to allow the skin to repair itself. Moisture also contributes to skin's healing from environmental stress.

Physical Sun Protection Matters

Sun protection is also of great importance. Wearing hats or caps, using umbrellas, and wearing clothing that protects against the sun's rays can minimize direct exposure to the sun.

All these are simple actions that serve as a physical barrier and prevent sunburn and long term damage to the skin, particularly between 10 a.m. and 4 p.m. These simple steps provide a physical barrier and reduce the risk of sunburn and chronic skin damage, particularly in the peak hours of 10 a.m. to 4 p.m.

Also read: Dermatologist Reveals What To Add And Remove From Skincare Routine For Season Change

Gut Health And Skin Connection

Another focus has been on the connection between gut health and healthy skin, as experts recognize how crucial the role of the gut is in maintaining healthy skin.

Probiotics can potentially improve the gut-skin axis and aid in the healing process and alleviate inflammation in the body. The better the gut environment, the better the skin will be able to recover and the less the exposure to the sun will age the skin.

Collagen May Support Skin Repair

Some people can use collagen supplements as an added benefit. Collagen is involved in supporting the dermis, the skin's structural component. Keeping collagen high can help promote skin repair and healing mechanisms.

Doctors say while sunscreen is important, long-term skin protection can be achieved through a variety of healthy habits, proper nutrition, hydration and physical sun protection measures, which must be followed daily.

Dr. Pravin Banodkar Senior Consultant Dermatologist Saifee Hospital