Wegovy Users Maintain Weight Loss for 4 Years: Here's How It Works

Updated Dec 3, 2024 | 09:00 PM IST

SummaryWegovy, is primarily an antidiabetic medication used to treat Type 2 diabetes. People receiving weight-loss drug Wegrovy sustained weight loss for up to four years
wegovy

wegovy (Credit: Canva)

People receiving weight-loss drug Wegovy sustained weight loss for up to four years, shedding an average of 10% of their body weight in that time, as per a new study. Wegrovy is a brand that markets semaglutide injections, that have gained widespread attention for their weight-loss effects. The study also found that Semaglutide injections boost an individual's heart health, even when weight loss doesn't take place.

The study, called SELECT, was published in journal Nature Medicine. "At four years, we see ongoing benefits of semaglutide," said Cheng-Han Chen, MD, interventional cardiologist from Cardiologist, who was not involved in the research. Besides the weight loss, it also lead to a loss in cardiovascular outcomes.

The research was conducted on 17000 adults, who had obesity but did not have diabetes. Overall, people who received once-weekly injections of semaglutide lost on average 10.2% of their body weight over the course of four years. All of the study participants continued to lose weight for about 65 weeks, a year and three months, and then their weight remained at a stable level.

Were There Any Side Effects?

However, people's experience with the medication varied. Researchers found no unexpected safety issues with drug during trial. In fact, most the people who withdrew from the study were those who experienced the known symptsoms of the semaglutide injections like nausea, indigestion etc. This occurred mainly during the beginning of the study, as the dose of the medicine is increased to a maximally tolerated dose.

What Did The Results Say?

Of the people on the highest dose of Wegovy, 68% lost at least 5% of their body weight. This compared to 21% of people on the placebo. Additionally, of the total people on Wegovy about 23% lost at least 15% of their body weight. For those in the placebo group, only 1.7% lost that much body weight.

Semaglutide Shows Heart Benefits Beyond Weight Loss

Researchers found that even individuals who did not experience significant weight reduction while on the drug saw a reduced risk of major heart events. Recent analysis of the SELECT trial data revealed that semaglutide significantly lowers the risk of heart attack, stroke, and cardiovascular-related deaths in adults with obesity or those who are overweight. Notably, the results of this study lead the US FDA to approve Novo Nordisk's Wegovy for reducing heart-related risks in this group.

What Is Semaglutide?

Semglutide is the synthetic version of GLP-1—a natural hormone produced in the intestines that regulates blood sugar, appetite, and digestion. Now, every time you eat, your body produces various hormones, including GLP-1. These are called Post nutrition hormones, and help you absorb the energy you just consumed. GLP-1 travels to your pancreas, prompting it to produce insulin. It also travels to the hypothalamus in your brain, which gives you the feeling of being full or satiated. Ozempic imitates this hormone, thereby, silencing the food chatter in the brain. Interestingly, for some people this food chatter is really quiet ( people with low appetite) and for others it is an outburst, (people who generally binge eat.) So with Ozempic, silencing this self-talk in the brain, people tend to lose their appetite and eventually weight.

Are Their Any Side Effects Of Semaglutide?

Semaglutide, marketed under the brand name Wegovy, is primarily an antidiabetic medication used to treat Type 2 diabetes. It is also an anti-obesity drug used for long-term weight management. While it can be taken as a subcutaneous injection or orally, it has significant side effects. It primarily impacts your gastrointestinal tract and its side effects include constipation, nausea, abdominal pain, diarrhoea, and fatigue amongst others.

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Hantavirus: How Andes Strain Spreads Between Humans; Why It’s Not Another Pandemic

Updated May 9, 2026 | 11:00 PM IST

SummaryThe Andes virus is a rare but highly dangerous pathogen of hantavirus, found primarily in Argentina and Chile. It is the only type of hantavirus known to man to spread among humans.
Hantavirus: How Andes Strain Spreads Between Humans; Why It’s Not Another Pandemic

Credit: AI generated image

While the confirmation of the Andes strain of hantavirus behind the outbreak aboard the cruise ship MV Hondius in the South Atlantic has raised significant concerns of human-to-human transmission, experts from the International Hantavirus Society, as well as the World Health Organization (WHO), stated that the situation does not raise the risk of a pandemic.

So far, eight cases have been reported, including three deaths. The WHO has also confirmed that six cases have tested positive for the Andes virus, which can spread from person to person, through PCR testing.

The International Hantavirus Society, in a statement, warned that the virus differs significantly from most other hantaviruses because it can spread between people.

Founded in 2001, the Hantavirus Society is a global organization of scientists, clinicians, and researchers focused on studying hantaviruses, including their ecology, pathogenesis, and prevention.

“The virus on board the MV Hondius is the Andes strain of hantavirus. It is serious,” said the WHO DG in an open statement on the social media platform X.

However, the WHO and the members of the Hantavirus Society maintained that the current outbreak is not another COVID-19 outbreak.

So, first, let us understand all about the Andes Virus.

What Is Andes Virus

The Andes virus is a rare but highly dangerous pathogen of hantavirus, found primarily in Argentina and Chile. It is the only type of hantavirus known to man to spread among humans.

Unlike many hantaviruses seen in Europe, Asia, and North America, which are typically transmitted from infected rodents to humans, the Andes virus has repeatedly shown evidence of person-to-person spread.

As per experts, transmission usually occurs in situations involving prolonged or close contact. But how close is a question that has been recurring. The Hantavirus Society answers this.

“Over the past decades, multiple outbreak investigations, household clusters, nosocomial events, and genomic analyses have provided convincing evidence that ANDV can be transmitted between individuals under specific close-contact conditions. These may include household exposure, intimate contact, caregiving without suitable personal protective equipment, and prolonged exposure in poorly ventilated or crowded settings,” it said.

Pointing out decades of outbreak investigations, hospital clusters, and genetic studies, experts emphasized: “Human-to-human transmission of Andes virus should no longer be considered hypothetical”.

The scientists stressed that current evidence does not suggest the virus spreads easily through casual community interaction in the way diseases like measles, influenza, or COVID-19 do.

Also Read: Hantavirus Outbreak: How MV Hondius Passengers Will Be Screened And Evacuated

Andes Virus: High Fatality Rate A Concern

But the Andes virus is associated with hantavirus pulmonary syndrome (HPS) — a severe respiratory illness that can rapidly become fatal. Reported fatality rates range from 20% to 40%, depending on the outbreak setting, quality of medical care, and surveillance capacity.

Recent surveillance data highlight the seriousness of the disease:

  • Argentina reported 86 confirmed hantavirus cases in 2025, including 28 deaths.
  • Chile reported 35 confirmed cases, including 7 deaths.
Although annual case numbers remain relatively low, experts caution that this mainly reflects the rarity of exposure to infected rodents — not the absence of transmission risk once a human infection occurs.

Why Continuous Monitoring Is Important?

The first major indication of person-to-person transmission emerged during the 1996 El Bolsón/Esquel outbreak. More recently, the 2018–2019 Epuyén outbreak infected 34 people after a single index case attended crowded social gatherings while symptomatic.

Strict public health interventions — including isolation, quarantine, and active contact tracing — reduced transmission.

Read More: Hantavirus: Israel Confirms 1st Case as UK, Spain Probe Suspected Infections; Should You Be Worried?

The Hantavirus Society noted that a confined environment aboard the MV Hondius means that passengers and crew may still be within the virus’s incubation period.

The scientists thus warned, "A negative PCR test shortly after exposure does not necessarily rule out future infection.” They recommend “ongoing monitoring, repeat testing where necessary, and antibody testing for close contacts”.

Experts are also examining whether transmission could occur during early or minimally symptomatic stages, rather than only after obvious illness begins.

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Can Thalassemia Affect Brain Health? Experts Explain

Updated May 8, 2026 | 09:14 PM IST

SummaryThalassemia is not only a physical health condition, but also an emotional and psychological challenge. Thalassemia may indirectly affect brain development in children, as well as cause mental health issues like anxiety and depression.
Can Thalassemia Affect Brain Health? Experts Explain

Credit: AI generated image

While thalassemia is known widely as a blood disorder, its impact can extend far beyond anemia and transfusions, said experts on World Thalassemia Day today.

World Thalassemia Day is observed every year on May 8 to raise awareness about the inherited blood disorder caused by faulty genes.

The disorder, which often requires blood transfusions every fortnight, affects approximately 1.3 million people living with severe forms of thalassemia worldwide. About 1.5 percent of the global population is carriers, and the disease claims nearly 11,000 lives annually.

Speaking to HealthandMe, health experts raised concerns about the growing mental health and neurological challenges faced by patients, especially children and young adults living with the condition.

Dr. Praveen Gupta, Chairman – Marengo Asia International Institute of Neuro & Spine (MAIINS), Gurugram, shared that repeated blood transfusions are important and save the lives of thalassemia patients, but long-term transfusion therapy can potentially lead to neurological complications if not properly monitored.

“Chronic transfusions can cause iron overload, which is the accumulation of iron in critical organs such as the brain, and may impact cognitive and psychological function, as well as mood,” Dr. Gupta explained.

He added that "changes in oxygen supply and related complications may make patients more vulnerable to headaches, lethargy, or even undetected brain injury".

However, experts stress that most neurological complications can be prevented through multidisciplinary care, iron chelation therapy, and regular monitoring.

Can Thalassemia Affect Brain Development in Children?

The expert stated that thalassemia may also indirectly affect brain development in children, particularly when severe anemia continues for long periods and limits oxygen supply to the growing brain.

Dr. Gupta noted that poor oxygenation, nutritional deficiencies, iron overload from repeated transfusions, and metabolic complications may affect:

  • Cognitive function
  • Learning ability
  • Attention span
  • Overall neurodevelopment
  • Early warning signs may include:
  • Delayed speech
  • Difficulty concentrating
  • Poor school performance
  • Frequent headaches
  • Irritability
  • Developmental delays
“The good news is that with timely diagnosis, frequent transfusion support, iron chelation therapy, nutrition, and neurological monitoring, most children with thalassemia can grow into healthy, productive adults,” he told HealthandMe.

Also read: World Thalassemia Day 2026: Why Screening Before Marriage Or Pregnancy Is Important

Early Signs Parents Should Not Ignore

Dr. Vipin Khandelwal, Sr. Consultant Paediatric Haemato Oncology & BMT at Apollo Hospitals Navi Mumbai, told HealthandMe that thalassemia affects the blood’s ability to carry oxygen, and prolonged disruption can impact growth, immunity, bone health, and learning abilities.

“The early signs of thalassemia are often subtle, which is why many families miss them until anemia becomes severe,” he said.

Parents should watch for persistent symptoms such as:

  • Unusual tiredness
  • Pale appearance
  • Poor appetite
  • Difficulty gaining weight
  • Delayed growth
  • Delayed walking or speech
  • Reduced stamina
  • Bone pain
  • Recurrent weakness
“In older children and adolescents, delayed puberty, bone pain, reduced stamina, or recurrent weakness should not be ignored,” Dr. Khandelwal added.

He stressed that while thalassemia is inherited, many serious complications can be prevented with early diagnosis, regular check-ups, timely transfusions, and proper iron monitoring.

Why Depression and Anxiety Are Common Among Thalassemics?

Read More: Hantavirus Updates Of The Day: 8 May 2026 - US CDC Classifies Outbreak As 'Level 3' Emergency

Further, the experts also highlighted risk of anxiety, stress, low self-esteem, and depression among people with thalassemia who face lifelong blood transfusions, frequent hospital visits, leading to physical fatigue, and fear of complications. Over time, these challenges may increase, many often go unnoticed or untreated.

Dr. Roshan Dikshit, Senior Consultant, Haematology & Bone Marrow Transplant at Aakash Healthcare, told HealthandMe that thalassemia is not only a physical health condition, but also an emotional and psychological challenge. He stressed the need to provide mental support to thalassemic patients.

“Frequent hospital visits, lifelong blood transfusions, fear of complications, and social limitations can increase the risk of anxiety, stress, and depression, especially among teenagers and young adults,” said Dr. Roshan Dikshit, Senior Consultant, Haematology & Bone Marrow Transplant at Aakash Healthcare.

According to Dr. Dikshit, many patients struggle with:

  • Low self-esteem
  • Isolation
  • Emotional fatigue.

Importantly, these emotional challenges often go unnoticed.

“Mental health support should be considered an essential part of thalassemia care. Counseling, family support, social acceptance, and open communication can significantly improve a patient’s emotional well-being and quality of life,” he said.

He also emphasized that early psychological intervention can help patients cope better with the disease and reduce the long-term mental health burden associated with chronic illness.

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Can Children Develop Eye Infections While Swimming?

Updated May 9, 2026 | 07:00 AM IST

SummaryChlorine in swimming pools can cause irritation in the eyes.
Eye infections

Conjunctivitis can spread in shared water. (Photo credit: AI generated)

For most children, a swimming pool is all about fun: summer afternoons, splashing around, and playing with friends. It feels harmless, even healthy, and in many ways, it is. But over time, a small pattern has started to show up. Parents notice it after a swimming session: red eyes, constant rubbing, and sometimes complaints of burning or discomfort that were not there before. It does not always seem serious in the beginning, which is probably why it gets ignored. Still, it keeps happening often enough to be worth paying attention to.

In an interview with Health and Me, Dr Neeraj Sanduja, Director, Viaan Eye & Retina Centre, Gurugram, explained how swimming pool time could be giving your children eye infections.

What’s Really Causing the Problem

It is easy to assume the water is the issue, but that is only part of it. Most pools are treated with chlorine, which is necessary to keep them clean. The problem starts when chlorine mixes with other things that end up in the water: sweat, dirt, and even small amounts of urine. That mix creates compounds that can irritate the eyes.

Children are more likely to be affected because they spend more time in the water and often open their eyes while swimming. The natural layer that protects the eyes gets disturbed, and that is when the redness or burning starts. In some cases, it is not just irritation. If the pool is not maintained properly, there is also a risk of infections. Conjunctivitis, for example, can spread quite easily in shared water.

What Parents Usually Notice First

The signs are not always dramatic. In fact, they are easy to miss at first. A child may come back with slightly red eyes and say they sting a bit or keep rubbing them without thinking much of it. Sometimes there is watering that does not settle quickly.

If it is just mild irritation, it usually improves within a few hours. But if the redness stays, or there is itching, swelling, or discharge, it is likely to be something more than just chlorine exposure. That is usually the point at which it needs attention.

Small Things That Actually Help

The good part is that this is mostly preventable. Swimming goggles make a difference. Not everyone likes wearing them, especially younger children, but they do help keep the eyes protected. A proper fit matters; otherwise, water still gets in.

Rinsing the face and eyes with clean water after getting out of the pool is another simple step. It helps wash away whatever is left behind. Also, children tend to rub their eyes when they feel discomfort. That only makes things worse. It is a small habit, but one that needs to be corrected gently. And then there is the pool itself. A clean-looking pool is not always a safe one. Maintenance matters more than appearance.

When It Shouldn’t Be Ignored

Most of the time, these issues settle quickly, but not always. If the same problem keeps coming back after every swim, or if the symptoms last beyond a day, it is better to get it checked. Waiting it out does not always help. Children may not always explain clearly what they are feeling. So, small changes, like avoiding light or blinking more than usual, can be signs that something is not right.

Finding the Right Balance

Swimming is still one of the best activities for children. It keeps them active, helps them relax, and is something they genuinely enjoy. The idea is not to stop it, just to be a little more careful. A few small steps can go a long way in preventing discomfort later. And once that becomes part of the routine, the experience stays what it is meant to be: fun, safe, and worry-free.

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