People receiving weight-loss drug Wegovy sustained weight loss for up to four years, shedding an average of 10% of their body weight in that time, as per a new study. Wegrovy is a brand that markets semaglutide injections, that have gained widespread attention for their weight-loss effects. The study also found that Semaglutide injections boost an individual's heart health, even when weight loss doesn't take place.

The study, called SELECT, was published in journal Nature Medicine. "At four years, we see ongoing benefits of semaglutide," said Cheng-Han Chen, MD, interventional cardiologist from Cardiologist, who was not involved in the research. Besides the weight loss, it also lead to a loss in cardiovascular outcomes.

The research was conducted on 17000 adults, who had obesity but did not have diabetes. Overall, people who received once-weekly injections of semaglutide lost on average 10.2% of their body weight over the course of four years. All of the study participants continued to lose weight for about 65 weeks, a year and three months, and then their weight remained at a stable level.

Were There Any Side Effects?

What Did The Results Say?

Of the people on the highest dose of Wegovy, 68% lost at least 5% of their body weight. This compared to 21% of people on the placebo. Additionally, of the total people on Wegovy about 23% lost at least 15% of their body weight. For those in the placebo group, only 1.7% lost that much body weight.

Semaglutide Shows Heart Benefits Beyond Weight Loss

Researchers found that even individuals who did not experience significant weight reduction while on the drug saw a reduced risk of major heart events. Recent analysis of the SELECT trial data revealed that semaglutide significantly lowers the risk of heart attack, stroke, and cardiovascular-related deaths in adults with obesity or those who are overweight. Notably, the results of this study lead the US FDA to approve Novo Nordisk's Wegovy for reducing heart-related risks in this group.

What Is Semaglutide?

Are Their Any Side Effects Of Semaglutide?

Semaglutide, marketed under the brand name Wegovy, is primarily an antidiabetic medication used to treat Type 2 diabetes. It is also an anti-obesity drug used for long-term weight management. While it can be taken as a subcutaneous injection or orally, it has significant side effects. It primarily impacts your gastrointestinal tract and its side effects include constipation, nausea, abdominal pain, diarrhoea, and fatigue amongst others.

A medical expert has revealed that you might be able to tell which winter illness you’re dealing with just by the type of cough you have. According to Dr. Rupa Parmar, a GP and medical director at Midland Health, coughing can present differently depending on whether you have a cold, flu, or COVID-19. During the winter months, certain infections become more common. Viruses spread more easily in cold weather, and spending more time indoors with others makes transmission more likely.

Still, it can be tricky to identify exactly what’s wrong because symptoms often overlap. Dr. Parmar advises: “There are some key differences between a cold, Covid, and flu that make it easier to tell them apart. But if you’re unsure, always check with your doctor. It’s better to be safe when it comes to your health.”

Cold and Flu

Dr. Parmar explained: “A cold usually causes a mild cough, while a flu cough is typically dry.” According to the NHS, cold symptoms develop gradually over two to three days. In contrast, flu symptoms “come on very quickly,” with a dry cough being a key sign.

Covid

Covid can also cause a dry cough, but it is usually persistent. Dr. Parmar said: “Covid tends to trigger a dry, continuous cough. Many people cough for over an hour at a time or have three or more coughing episodes in a single day.”

The NHS defines this as: “A new, continuous cough—meaning you’re coughing a lot for more than an hour or have three or more coughing episodes within 24 hours.”

What Is ‘Super Flu’?

NHS officials are warning that the UK may be facing an unusually severe flu season. Cases have started a month earlier than usual, driven by a stronger strain of the influenza A(H3N2) virus, sometimes being called “super flu.” Despite its intensity, vaccines remain effective against this strain, offering protection to those who get immunized.

Other Key Covid Symptoms

Other signs of Covid to watch for include:

• High temperature—you may feel hot, cold, shivery, or notice heat on your chest or back (you don’t always need a thermometer)
• Loss or change of smell or taste
• Shortness of breath
• Feeling very tired or drained
• Body aches
• Headache
• Sore throat
• Stuffy or runny nose
• Loss of apetite
• Diarrhea
• Nausea or vomiting

The NHS warns: “Covid symptoms can resemble those of other illnesses like colds or flu. Most people recover within a few weeks, but some may take longer. If you have a cough, pharmacists can offer guidance on treatment.”

If You Have Covid

The NHS advises staying at home and avoiding contact with others if you or your child:

• Have a high temperature
• Do not feel well enough to attend work, school, childcare, or daily activities
• You can resume normal activities once you feel better or no longer have a high temperature.

The much-feared “winter vomiting disease,” commonly known as norovirus, is once again spreading rapidly across the United States.

Norovirus is an extremely contagious stomach virus that triggers sudden and intense episodes of vomiting and diarrhea. Anyone who has had it knows how abruptly it strikes. You can feel normal one moment and then find yourself completely incapacitated by stomach distress the next. With the holiday season nearing and people gathering indoors, norovirus infections are climbing nationwide.

Winter Vomiting Disease In The US

Data from WastewaterSCAN, a program that tracks disease levels through municipal wastewater, shows that norovirus activity is currently classified as “high” across the U.S., with a sharp rise over the past three weeks. Marlene Wolfe, Ph.D., a professor at Emory University and director of WastewaterSCAN, told TODAY.com that the upward trend is clear and concerning.

At present, the highest levels are being recorded in the Midwest, the South, and the Northeast. States reporting notable spikes include Alabama, Connecticut, Florida, Indiana, Massachusetts, and Michigan.

In Bedford, Massachusetts, an elementary school shut down for two days this week after more than 130 students were absent with stomach-related symptoms, prompting officials to suspect a norovirus outbreak, according to NBC10 Boston. Cruise ships are also seeing a rise in outbreaks, with norovirus spreading quickly among passengers at sea.

This year’s increase appears to be arriving slightly earlier than usual and is likely linked to a newer strain of the virus, which drove a particularly severe 2024–2025 season. Last winter, norovirus cases reached their highest levels in more than a decade.

Norovirus GII.17 Variant

Since the early 2000s, most norovirus outbreaks have been linked to a strain known as GII.4, according to previous reports from NBC News. Roughly a decade ago, another strain called GII.17 first appeared in Asia and has expanded significantly in recent years. During the 2024–2025 season, GII.17 accounted for 75 percent of norovirus outbreaks in the U.S., compared with less than 10 percent in 2023, a CDC study found.

“When a new strain appears, it can spread very quickly,” Roberts says. “That is exactly what happened last year.”

Experts are unsure whether GII.17 spreads more easily than GII.4. However, they say more people may be vulnerable because they lack immunity to this newer variant.

Infection with norovirus does offer some level of immune protection, but it is incomplete, Schaffner explains.

“We do not know how long that immunity lasts,” Roberts says. “And it likely does not protect you against a different strain.”

If a large portion of the population is susceptible, the virus may have more opportunities to circulate widely. How this season unfolds remains uncertain.

Winter Vomiting Disease: Norovirus Symptoms

“This is not a subtle illness,” Roberts says. Symptoms typically appear suddenly, usually within 12 to 48 hours of exposure.

Some common signs of norovirus are:

• Vomiting
• Diarrhea
• Nausea
• Stomach pain and cramping

Some people may also experience a mild fever, chills, or headache, according to the CDC.

“The good news is that it does not usually last long,” Schaffner says. “Most people feel terrible for about two days, then recover.”

In most cases, symptoms resolve on their own within one to three days.

However, the virus can cause significant fluid loss, increasing the risk of dehydration. Certain groups face a higher risk of severe illness and hospitalization, including children under 5 and adults over 85.

Medical care should be sought if symptoms continue beyond a few days, if there is blood in vomit or stool, or if signs of dehydration appear, such as dizziness or dark urine, according to the Cleveland Clinic.

Winter Vomiting Disease: Norovirus Treatment

There is no medication that directly treats norovirus. Care focuses on managing symptoms through rest and fluid replacement, Roberts says. Drinks that replenish electrolytes can be helpful.

“It is better to take small sips,” Schaffner advises. “Drinking too much at once can make vomiting worse.”

In more serious cases, intravenous fluids may be necessary to prevent dehydration. Anyone with concerns should contact a health care provider, Schaffner adds.

There is currently no approved vaccine for norovirus, though a Moderna vaccine candidate is undergoing phase 3 clinical trials.

Winter Vomiting Disease: How Does Norovirus Spread?

“It is an especially troublesome virus because it spreads so easily and in so many ways,” Schaffner says. An infected person can release billions of virus particles through vomit or stool. “It only takes one to ten particles to cause an infection,” he notes. Norovirus usually spreads through the fecal-oral route, Roberts explains, when virus particles from feces make their way into the mouth, often via unwashed hands.

Some common ways how the virus spread are:

• Close contact with someone who is infected
• Touching contaminated surfaces and then touching the mouth
• Eating or drinking contaminated food or beverages
• Breathing in or swallowing particles released during vomiting

People are most contagious from the time symptoms begin until a few days after they feel better. However, the virus can continue to be shed in stool for up to two weeks after recovery, Roberts says.

Norovirus can survive on surfaces, objects, and foods for extended periods. Foods frequently linked to outbreaks include leafy greens, fresh produce, and shellfish, according to the CDC.

Does Hand Sanitizer Kill Norovirus?

Norovirus is especially difficult to eliminate. Alcohol-based hand sanitizers and cleaners are largely ineffective because the virus has a tough outer shell that alcohol cannot break down. “The only way to remove it from your hands is to physically wash it away,” Schaffner says. “Soap and water lift the virus off the skin and rinse it down the drain.”

A doctor has highlighted a common kitchen spice that may work just as effectively as omeprazole in relieving heartburn, acid reflux, and indigestion. Omeprazole is often prescribed for these conditions as a Proton Pump Inhibitor (PPI), helping to reduce the amount of acid produced in the stomach.

About 15% of the UK population takes a PPI like omeprazole. In England alone, over 73 million PPI prescriptions were issued in 2022–23, with omeprazole among the most commonly prescribed.

What Is Omeprazole Used For?

Omeprazole is a drug that lowers the amount of acid the stomach produces. Part of a class of medicines called proton pump inhibitors (PPIs), it is used to treat and prevent a range of acid-related problems, as per Mayo Clinic.

The length of treatment with omeprazole, as advised by your doctor, depends on the condition being treated and the prescribed dosage. Following your healthcare provider’s instructions and completing the full course of medication, even if symptoms improve, is important.

However, long-term use of omeprazole can increase the risk of various health issues, making regular consultations with your GP important, reports the Mirror. Prolonged acid suppression and changes in gut bacteria caused by extended use can result in several complications.

Lower stomach acid can reduce the body’s ability to absorb key nutrients, potentially causing deficiencies in magnesium, vitamin B12, calcium, and iron. Long-term use may also raise the risk of bone fractures and kidney problems. Other possible issues include growths in the stomach, dementia, and liver or heart problems.

Suppressing stomach acid, which normally kills harmful bacteria, can make the body more prone to infections such as community-acquired pneumonia or Clostridioides difficile infection, which causes severe diarrhoea and stomach pain.

Omeprazole Alternative: What Is The Spice, And How Can It Help?

Experts suggest that one kitchen spice could match omeprazole’s effectiveness while avoiding its health risks. Dr Michael Ruscio, DC, DNM, says curcumin, the active compound in turmeric, may be “just as effective,” according to research.

Dr Ruscio, a naturopathic practitioner, clinical researcher, and author, has published work in peer-reviewed medical journals. He is the Chief Health Officer and Head of Research at RIFM, and Founder and CEO of DrRuscio.com.

In a YouTube video for his 145k subscribers, Dr Ruscio explained that curcumin may help manage heartburn and acid reflux without relying on PPIs. He said: “Let me show you an important study demonstrating the power of anti-inflammatory interventions. You’ve probably heard of curcumin, this anti-inflammatory spice. A 2023 randomized control trial compared omeprazole to curcumin at two grams per day for one month.”

Quoting the study, “Curcumin and omeprazole showed similar effectiveness for functional dyspepsia,” a term covering symptoms like fullness, GORD, and indigestion. Dr Ruscio added, “It’s remarkable that curcumin, which also has benefits such as reducing joint pain, can be as effective as omeprazole. And it doesn’t carry the long-term risks of acid suppression that come with omeprazole.”

Curcumin’s anti-inflammatory and antioxidant properties may reduce oesophageal inflammation caused by stomach acid. Animal studies suggest it can protect the stomach lining from damage caused by certain medications and other irritants.

What Did The Study's Findings Reveal?

The referenced research, published in BMJ Journals as “Curcumin and proton pump inhibitors for functional dyspepsia: a randomized, double-blind controlled trial,” found that a daily dose of curcumin provided relief from functional dyspepsia symptoms comparable to omeprazole.

No significant side effects were observed, though liver function tests showed some decline in overweight participants taking curcumin. The researchers noted limitations including the short study period and lack of long-term data.

They concluded, “This multicentre randomized controlled trial provides strong evidence for treating functional dyspepsia.”

Functional dyspepsia, or chronic indigestion, occurs as persistent or recurring discomfort in the upper abdomen. Symptoms may include bloating, burping, nausea, or feeling full too quickly, often signaling issues in the oesophagus, stomach, or duodenum.

Despite promising results, it is essential to consult your doctor before making major changes to your diet or replacing prescribed medication with supplements. A discussion with your GP can help identify the most effective approach to managing your health.

What Else Is Curcumin Good For?

Curcumin is a powerful antioxidant that neutralizes free radicals, which can damage cells and contribute to ageing and illnesses like heart disease and cancer. Studies suggest it may relieve symptoms of osteoarthritis and rheumatoid arthritis, easing joint pain, stiffness, and inflammation.

Some research indicates curcumin may be as effective as certain nonsteroidal anti-inflammatory drugs (NSAIDs) for pain relief.

It may also support brain health by raising levels of brain-derived neurotrophic factor (BDNF), a hormone important for memory and learning. Researchers are investigating its potential to protect cognitive function with age and against conditions like Alzheimer’s.

Additionally, curcumin’s anti-inflammatory and antioxidant effects, along with possible benefits for cholesterol and blood pressure, may reduce the risk of heart disease.