People receiving weight-loss drug Wegovy sustained weight loss for up to four years, shedding an average of 10% of their body weight in that time, as per a new study. Wegrovy is a brand that markets semaglutide injections, that have gained widespread attention for their weight-loss effects. The study also found that Semaglutide injections boost an individual's heart health, even when weight loss doesn't take place.

The study, called SELECT, was published in journal Nature Medicine. "At four years, we see ongoing benefits of semaglutide," said Cheng-Han Chen, MD, interventional cardiologist from Cardiologist, who was not involved in the research. Besides the weight loss, it also lead to a loss in cardiovascular outcomes.

The research was conducted on 17000 adults, who had obesity but did not have diabetes. Overall, people who received once-weekly injections of semaglutide lost on average 10.2% of their body weight over the course of four years. All of the study participants continued to lose weight for about 65 weeks, a year and three months, and then their weight remained at a stable level.

Were There Any Side Effects?

What Did The Results Say?

Of the people on the highest dose of Wegovy, 68% lost at least 5% of their body weight. This compared to 21% of people on the placebo. Additionally, of the total people on Wegovy about 23% lost at least 15% of their body weight. For those in the placebo group, only 1.7% lost that much body weight.

Semaglutide Shows Heart Benefits Beyond Weight Loss

Researchers found that even individuals who did not experience significant weight reduction while on the drug saw a reduced risk of major heart events. Recent analysis of the SELECT trial data revealed that semaglutide significantly lowers the risk of heart attack, stroke, and cardiovascular-related deaths in adults with obesity or those who are overweight. Notably, the results of this study lead the US FDA to approve Novo Nordisk's Wegovy for reducing heart-related risks in this group.

What Is Semaglutide?

Are Their Any Side Effects Of Semaglutide?

Semaglutide, marketed under the brand name Wegovy, is primarily an antidiabetic medication used to treat Type 2 diabetes. It is also an anti-obesity drug used for long-term weight management. While it can be taken as a subcutaneous injection or orally, it has significant side effects. It primarily impacts your gastrointestinal tract and its side effects include constipation, nausea, abdominal pain, diarrhoea, and fatigue amongst others.

PMOS is often discussed mainly in connection with periods, hormonal changes and pregnancy. However, women’s health is much broader than fertility. Changes linked to hormonal health can also influence weight, energy levels, skin, hair, metabolism and emotional well-being.

This is why women should not focus only on whether their periods are regular or whether they are planning a pregnancy. Looking at overall health can help identify concerns early and support better long-term well-being.

PMOS can affect more than periods

Changes in the menstrual cycle may be one of the first signs that something needs attention, but they are not the only concern. Women may also notice changes in weight, acne, hair growth or hair thinning, tiredness and mood.

Persistent or unusual changes should not be ignored, even if a woman is not planning to have children. Speaking to a healthcare professional can help identify the possible cause and decide whether further evaluation is needed.

Also read: Ozempic, Wegovy & PMOS: How GLP-1 Drugs Are Changing PMOS Treatment?

Think beyond fertility

Fertility is an important part of women’s health, but it should not be the only focus. Women should also pay attention to their overall metabolic health, including blood pressure, blood sugar, cholesterol and weight when appropriate.

A balanced diet, regular physical activity, adequate sleep and maintaining a healthy weight can support better health. Medical care should also take into account age, lifestyle, family history and existing health conditions.

Mental health matters too

Hormonal and reproductive health concerns can affect emotional well-being. Worries about periods, weight, appearance or future fertility may contribute to stress, anxiety or low mood. Women should feel comfortable discussing these concerns with their doctor. Mental health is an important part of overall health and should be addressed along with physical symptoms.

How can women take better care of their health?

Women can start by tracking changes in their menstrual cycle and paying attention to other symptoms. Regular physical activity, nutritious food, adequate sleep and stress management can support overall well-being.

Those planning pregnancy should discuss their plans with a doctor in advance. However, even women who are not planning pregnancy should continue regular health monitoring.

Also read: From Insulin Resistance to Fertility: Understanding the Metabolic Side of PCOS

Tips for long-term health

• Keep track of menstrual changes and other symptoms.

• Maintain a balanced and nutritious diet.

• Stay physically active.

• Prioritise good sleep and stress management.

• Monitor blood pressure, blood sugar and cholesterol when advised.

• Do not ignore persistent hormonal or menstrual changes.

• Discuss fertility plans early with a healthcare professional.

• Pay attention to mental and emotional health.

PMOS should not be viewed only through the lens of periods or pregnancy. Women’s health also includes metabolic, hormonal, physical and emotional well-being. By looking beyond fertility, monitoring health regularly and making healthy lifestyle choices, women can take better care of themselves at every stage of life.

As men enter their 40s, paying attention to prostate health becomes increasingly important. The prostate is a small gland located just below the urinary bladder and surrounding the urethra. It plays an important role in the male reproductive system.

With advancing age, the prostate may undergo changes. One of the most common conditions is benign prostatic hyperplasia (BPH), a non-cancerous enlargement of the prostate. Although BPH is not cancer, it can cause troublesome urinary symptoms and significantly affect quality of life.

Prostate cancer is another important condition that men should be aware of, particularly as they grow older or if they have certain risk factors, such as a family history of prostate cancer.

Warning Signs Men Should Not Ignore

Urinary symptoms can have several causes, but persistent or worsening changes should not simply be attributed to ageing.

1. Frequent Urination

Needing to urinate more frequently than usual, particularly waking up several times at night to pass urine, may be associated with prostate enlargement or other urinary conditions. Repeated nighttime urination can also interfere with sleep and daily activities.

2. Difficulty Starting Urination

Hesitancy, difficulty initiating the urinary stream, a weak or interrupted flow, or needing to strain to urinate can occur when an enlarged prostate obstructs the urethra.

3. Feeling of Incomplete Bladder Emptying

If you frequently feel that your bladder has not emptied completely after urination, it is important to seek medical evaluation. Persistent incomplete emptying can sometimes lead to complications such as urinary retention or recurrent urinary infections.

Also read: Urine Leakage When You Cough, Sneeze Or Exercise? It Could Be Pelvic Floor Dysfunction, Say Experts

4. Urinary Urgency

A sudden, strong and difficult-to-control urge to urinate may indicate a prostate or bladder-related problem. Urgency, particularly when accompanied by increased frequency or leakage, deserves medical attention.

5. Blood in the Urine or Semen

Blood in the urine (haematuria) or semen (haematospermia) should never be ignored. Although infections, inflammation and other benign conditions can cause these symptoms, they may occasionally be associated with more serious urinary or reproductive tract disorders. Medical evaluation is therefore important.

6. Persistent Pelvic, Back or Hip Pain

Persistent pain in the pelvis, lower back, hips, or discomfort associated with urination should be assessed by a doctor, especially when it is unexplained or accompanied by other urinary symptoms.

When Should You See a Urologist?

Not every urinary symptom indicates prostate cancer. Conditions such as BPH, urinary tract infections, prostatitis, bladder disorders and certain medications can also cause similar symptoms. However, persistent, recurrent or progressively worsening urinary symptoms should not be self-diagnosed or dismissed as a normal part of ageing. Men in their 40s and beyond should consider discussing their prostate health with a urologist, particularly if they have:

• Persistent urinary symptoms
• A family history of prostate cancer
• A previous elevated PSA level
• Other risk factors for prostate cancer
• Blood in the urine or semen
• Persistent pelvic or lower back symptoms

Also read: Prostate Cancer: What's Fact, What's Fiction

Depending on the individual's age, symptoms, medical history and risk factors, evaluation may include a clinical examination, urine tests, PSA blood test, ultrasound or other appropriate imaging and, when indicated, further prostate assessment.

It is important to understand that an elevated PSA level does not automatically mean prostate cancer. PSA can increase for several reasons, including benign prostate enlargement, inflammation, infection and other prostate-related conditions. Your urologist can interpret the PSA result in the context of your overall risk profile and determine whether further evaluation is required.

Early Detection Can Make a Difference

Maintaining prostate health is an important part of overall men's health. A healthy lifestyle—including maintaining a healthy body weight, exercising regularly, eating a balanced diet, limiting tobacco and maintaining good metabolic health—can contribute to overall well-being.

Most importantly, know what is normal for you and pay attention to changes in your urinary or sexual health.

Urinary problems are not something men should simply accept as an inevitable consequence of ageing. Early medical evaluation can identify the underlying cause, provide appropriate treatment and, when necessary, help detect serious prostate conditions at an earlier stage.

Takeaway for Men Over 40

Don't ignore changes in your urinary habits. Don't self-medicate. Don't assume it's just ageing. If urinary symptoms persist or worsen, consult a urologist for appropriate evaluation and personalized advice. Your prostate health is an important part of your overall health—start paying attention to it today.

When people think of Alzheimer's specifically, memory loss is usually the first thing that comes to mind — forgetting recent conversations, repeating questions, struggling to recall familiar names. But Alzheimer's rarely announces itself through memory alone. It can also show up in how a person communicates, makes decisions, behaves, and manages the everyday tasks that once came naturally. People often mistake dementia and Alzheimer's for the same thing; however, dementia is not a single disease but a broad term for a decline in memory, thinking, and reasoning severe enough to interfere with daily life. Alzheimer's disease is the most common cause of dementia, accounting for a majority of cases.

Signs Families Often Misread

These early changes are easy to misattribute. A person who withdraws from social life may seem to be "losing interest." Someone who grows irritable may be written off as difficult or set in their ways. A family member who lets bills slide may appear distracted rather than unwell. Only when such shifts persist and clearly depart from a person's usual character do they warrant closer attention.

Communication And Language

Difficulty finding a familiar word now and then is normal. But losing the thread of a conversation, or struggling to express thoughts that once came easily, is different — and when this worsens over time, it's often family and friends who notice first.

Judgement And Everyday Decision-Making

Independence can erode quietly. Someone who has handled the household finances for decades may start making uncharacteristic decisions or find bills confusing. Following a familiar recipe, managing medication schedules, or planning a routine outing may become surprisingly hard. Family members frequently pick up on these lapses in judgement before they notice any memory trouble at all.

Behaviour And Personality

A once-sociable person may pull back from hobbies and company. Others may become anxious, suspicious, or emotionally distant in ways that feel out of character. These shifts can be hard for loved ones to make sense of — especially when they seem intentional — but they often reflect real changes in how the brain is processing and responding to the world, not a change in who someone chooses to be.

Daily Functioning

There's a meaningful difference between misplacing your keys occasionally and repeatedly leaving objects in strange places with no memory of how they got there. Likewise, forgetting one appointment is ordinary; missing commitments again and again despite reminders is not. Trouble navigating familiar streets, preparing a simple meal, or keeping up with personal care can point to a broader change in cognitive function.

Not A Diagnosis In Itself

None of these changes automatically means Alzheimer's. Many have other causes — some of them treatable — which is exactly why a medical assessment matters: it helps identify what's actually going on and whether further evaluation is needed.

What helps: Patterns, Not Incidents

For families, tracking patterns is far more useful than reacting to isolated moments. When did the changes start? How often do they happen? Are they starting to affect independence? This kind of observation gives doctors much more to work with than a single anecdote.

How families respond matters too. Correcting or criticising someone for changes they can't control tends to breed frustration on both sides. A patient, supportive approach protects their dignity while making it easier to get them the care they need.

Alzheimer's, in short, is not only a disease of memory. Its earliest clues can surface in conversation, judgement, behaviour, or the small routines of daily life. Recognising these signs isn't about assuming the worst — it's about noticing when something is genuinely different, and knowing when that difference is worth a doctor's opinion.

By Dr. Tanushree Chawla, Neurologist, PB Health