Weight loss is usually considered a good thing, unexpected and extreme weight loss can be a sign of something in your body going very wrong. There could be some underlying issues that are causing your body to pull weight and nutrition from your muscles and body fat to keep you going. As you grow old, your limbs grow weaker, and same for your muscles, so you do lose some weight as you age, but losing a lot of it too quickly could be a sign of something much worse, Dementia. A recent study published in JAMA Network Open 2025 Cardiometabolic Trajectories Preceding Dementia in Community-Dwelling Older Individuals, has identified potential early indicators of dementia, including significant weight loss and specific digestive changes, appearing years before noticeable cognitive decline.

The study showed that people who later got dementia had their Body Mass Index, or BMI, go down faster than those who stayed healthy. BMI is a way to see if someone's weight is healthy for their height. This drop in BMI started happening many years before they were told they had dementia, sometimes as early as 11 years ago. Also, these people often started with a lower BMI to begin with. So, even though everyone's weight might change a little as they get older, the people who developed dementia had a much bigger and faster weight loss.

What Are Some Other Indicators Of Dementia?

Along with their BMI, the size of their waist also changed. People who ended up with dementia had smaller waist sizes, and this difference was noticeable about 10 years before they were diagnosed. This means that their bodies were changing in ways that showed up long before they or their doctors noticed any problems. So, not only was there weight loss, but also a loss of abdominal fat. This measurement is important because fat around the waist can be related to other health issues.

The study also found changes in their blood. Specifically, the "good" cholesterol, called HDL, went up in people who developed dementia. This increase happened about five years before they were diagnosed. It's tricky because HDL is usually seen as a good thing for your heart. But in this case, it seems like it might be a sign of changes happening in the brain. Scientists are still trying to understand why this happens.

Weight Loss Doesn’t Cause Dementia, Dementia Causes Weight Loss

When we see that people with dementia lose weight, it's easy to think that the weight loss is what caused dementia. But experts think it's the other way around. They call this "reverse causation." This means that the brain changes that cause dementia also cause people to lose weight. The brain changes can affect things like appetite, how the body uses food, and how people go about their daily lives. For example, people might forget to eat, have trouble making meals, or move around less.

While the study revealed a lot about different indicators of dementia and bodily changes, there are many limitations to the study. Everyone loses some weight as they get older. So, it's hard to know when weight loss is just a normal part of aging and when it's a sign of dementia. The study found that people with dementia lost weight faster, but it's still tricky to tell the difference in everyday life. Doctors need to look at other things, like memory tests, to figure out if someone's weight loss is a cause for concern.

If someone is losing weight without trying, and they're also having problems with their memory or thinking, it's important to talk to a doctor. It's not just about the weight loss; it's about the whole picture.

The ancient practice of yoga may help improve fertility and hormonal health in women with Polycystic Ovary Syndrome (PCOS), now renamed Polyendocrine Metabolic Ovarian Syndrome (PMOS), according to three studies led by researchers at the All India Institute of Medical Sciences (AIIMS), New Delhi.

PCOS is a multifactorial condition affecting millions of women and involves a complex interplay of reproductive, metabolic, and psychological factors that can significantly impact quality of life.

The condition can increase the risk of serious health complications, including heart disease, diabetes, hypertension, infertility, and, in some cases, cancer.

The studies, led by Dr. Rima Dada, Professor at the Laboratory for Molecular Reproduction and Genetics, Department of Anatomy, AIIMS Delhi, recommend lifestyle modifications, including yoga, as a primary approach to managing the condition.

“Yoga presents a comprehensive strategy for addressing PCOS, targeting hormonal imbalances, OS, mitochondrial function, metabolic syndrome, microRNA regulation, cellular longevity, and mental well‑being. It exemplifies the potential of mind‑body medicine in the treatment of complex disorders,” the researchers said, in the papers.

The papers were published in the Journal of Ayurveda and Integrative Medicine, The International Journal of Ayurveda Research and the International Journal of Yoga.

Yoga Led To Improvements In Hormonal Balance

The three studies involved more than 100 women and followed participants for up to 12 weeks. Participants practiced Asanas (physical postures), Pranayama (breathing techniques), and Dhyana (meditation) for 90 minutes a day, five days a week. The results showed significant improvements across multiple health parameters.

Women with PCOS who participated in the yoga intervention demonstrated significant reductions in:

• Anti-Müllerian Hormone (AMH)
• Luteinizing Hormone (LH)
• Testosterone levels

Also read: Yoga Shows Promise for Anxiety Relief And Seizure Control In Epilepsy, Claims AIIMS Study

“This hormonal balance has led to the restoration of menstrual cycles and improvements in hirsutism and acne, resulting in enhancements in physical appearance and psychological well-being,” the researchers stated.

Benefits Beyond Hormones

The studies also found that yoga helped regulate cellular oxidative stress, offering protection against DNA damage and epigenetic changes. Researchers also reported improvements in several metabolic markers, including reductions in:

• Glucose
• Fructose
• D-ribose
• Xanthine
• Cholesterol
• Triglycerides
• Body weight

These findings highlight yoga's potential to address key mechanisms underlying PCOS and support its use as a cost-effective, non-pharmacological, and sustainable therapy for managing the condition.

The studies also found that yoga helped alleviate symptoms of depression among women with PCOS, suggesting it may serve as an effective complementary therapy in managing the condition.

Researchers concluded that regular yoga practice could help prevent, delay, and manage PCOS symptoms.

Read More: India Launches New Yoga Protocols To Fight Diabetes, High BP, Asthma

What Is PCOS?

PCOS is a complex lifestyle disorder that appears to primarily affect the ovaries but is increasingly recognized as a systemic condition affecting multiple organs and body systems.

If not diagnosed and managed early, it can contribute to serious health complications, including non-alcoholic fatty liver disease (NAFLD), cardiovascular disease, hypertension, and Alzheimer's disease.

While treatments such as anti-androgen medications, insulin-sensitizing agents, and fertility therapies remain important, experts note that PCOS also has a strong psychosomatic component that can benefit from lifestyle and mind-body interventions.

From PCOS to PMOS

PCOS affects more than 170 million women worldwide. In May, it was officially renamed Polyendocrine Metabolic Ovarian Syndrome (PMOS).

The new name reflects a major shift in understanding the condition—from a predominantly gynecological disorder to a complex multisystem condition affecting several aspects of health. The term PMOS acknowledges that the condition affects:

• Endocrine health
• Metabolic health
• Reproductive health
• Dermatological health
• Psychological health

Back pain is one of the most common health complaints worldwide, affecting a large proportion of adults at some point in their lives. In most cases, it is caused by benign musculoskeletal issues such as muscle strain, poor posture, or disc-related problems, and it tends to improve with rest, physiotherapy, or simple medication. However, not all back pain originates from the spine. In some situations, pain felt in the lower back or flank region may be linked to underlying kidney conditions, including kidney cancer. As renal cell carcinoma often progresses silently in its early stages, symptoms may be delayed, making it important to recognise when back pain is unusual.

Why Kidney Cancer Can Cause Back Pain

Dr Raj Nagarkar, Chief Surgical Oncologist at HCG Manavata Cancer Centre, Nashik, said, "The kidneys are located deep in the upper abdomen, on either side of the spine, just below the rib cage. When a tumour develops in this region, it can cause pain through several mechanisms. As the tumour grows, it may stretch the kidney’s outer fibrous capsule, leading to a persistent, dull ache in the flank area between the ribs and hip. In some cases, fragile tumour blood vessels may bleed internally or form clots that obstruct urine flow, resulting in sudden, sharp pain that can resemble renal colic. Larger tumours may also press on surrounding nerves or structures, producing discomfort that may be mistaken for back or abdominal pain."

Unlike musculoskeletal pain, which typically improves with movement or rest, kidney-related pain is often constant, may worsen at night, and does not respond well to routine pain relief or physiotherapy.

Red Flags When Back Pain Needs Further Diagnosis

While back pain alone is rarely a sign of kidney cancer, certain accompanying symptoms should raise concern. One of the most important warning signs is blood in the urine, which may appear pink, red, or dark brown and can sometimes be intermittent. Persistent flank pain associated with a palpable mass under the ribs may indicate more advanced disease. Unexplained weight loss, ongoing fatigue, or a general sense of weakness can reflect systemic illness. Some patients may experience intermittent fever without infection, new-onset high blood pressure, or swelling in the legs and ankles due to impaired venous drainage. Anaemia-related symptoms such as dizziness, breathlessness, or pallor may also be present. When back pain persists beyond a few weeks and is accompanied by any of these features, further medical evaluation is strongly recommended.

Differentiating Musculoskeletal Back Pain from Kidney Cancer Pain

It is also important to distinguish kidney-related pain from common musculoskeletal back pain. Mechanical back pain is usually localised to the lower back, may radiate to the legs, and often begins after physical strain or injury. It tends to improve with rest, heat application, or physiotherapy. In contrast, kidney cancer pain is typically one-sided, located higher in the flank below the ribs, and develops gradually without a clear trigger. It is often persistent, may disturb sleep, and is not relieved by standard pain management approaches. Unlike spinal pain, it is more likely to be associated with systemic symptoms such as haematuria, weight loss, or fatigue.

Who Is at Higher Risk?

Certain individuals are at higher risk of developing kidney cancer and should be particularly attentive to persistent flank pain. Risk factors include smoking, which significantly increases exposure to kidney-damaging toxins, obesity, long-standing hypertension, chronic kidney disease or dialysis, and a family history of kidney cancer or genetic conditions such as von Hippel-Lindau disease. Occupational exposure to industrial chemicals like trichloroethylene or cadmium may also contribute to risk. When multiple risk factors are present, even mild or persistent symptoms should not be ignored.

Diagnosing Kidney Cancer

If warning signs are suspected, doctors typically begin evaluation with simple and non-invasive tests. A urine analysis can detect microscopic or visible blood, while blood tests help assess kidney function, anaemia, and calcium levels. Imaging plays a crucial role, with ultrasound often used as the first-line investigation, followed by a contrast-enhanced CT scan for detailed evaluation of tumour size and spread. In selected cases, a biopsy may be performed, although it is not always required before treatment.

Treatment and Outcomes

Treatment outcomes for kidney cancer have improved significantly in recent years. In early-stage disease, partial nephrectomy allows removal of the tumour while preserving healthy kidney tissue, often using minimally invasive or robotic techniques that support faster recovery. In more advanced cases, targeted therapies and immunotherapy help control disease progression and improve quality of life, with many patients able to maintain daily activities during treatment. For small, slow-growing tumours in selected individuals, active surveillance may be an appropriate option.

Listening to the Warning Signs

While most back pain is benign and related to musculoskeletal causes, persistent or unusual pain, especially when accompanied by symptoms such as blood in the urine, unexplained weight loss, or systemic changes, should not be ignored. Kidney cancer often develops silently, and early signs can be subtle. Unlike muscular pain, which is typically movement-related and self-limiting, kidney-related pain is deeper, more persistent, and often associated with other warning features.

Vanessa Trump, the former wife of Donald Trump Jr., has announced that she is beginning the second stage of her breast cancer treatment.

In an Instagram post, Trump said she has spent the past four weeks recovering from surgery.

She said she was “grateful to be healing and moving forward.” “Sending love, strength, and hope to everyone fighting this battle,” she wrote.

The 48-year-old mother of five first revealed her breast cancer diagnosis in late May, saying she was working closely with her medical team to develop a treatment plan.

However, Vanessa Trump has not disclosed the type of breast cancer she has been diagnosed with or provided details about the next phase of her treatment.

What Is Breast Cancer?

Breast Cancer occurs when abnormal cells in the breast grow uncontrollably, often beginning in the milk ducts or lobules. It remains the most commonly diagnosed cancer among women worldwide.

Breast cancer is also the leading cause of cancer mortality among women worldwide and the most common cancer diagnosed overall, accounting for approximately 2.3 million new cases and 670,000 deaths annually, according to the World Health Organization.

Also read: Can Wegovy Improve Survival In Breast Cancer Patients? This Study Suggests It Could

Every year, breast cancer accounts for about 30% of all new cancer cases in US women. The average risk of a woman in the US developing breast cancer sometime in her life is about 13 per cent.

A recent study published in The Lancet Oncology projected that global breast cancer cases could rise to more than 3.5 million annually by 2050.

Major Lifestyle Risk Factors

In 2023, 28 percent of the global breast cancer burden (6.8 million years of healthy life lost to disability, illness, and early death) was linked to six potentially modifiable risk factors.

These include:

• High red meat consumption
• Tobacco use and second-hand smoke exposure
• High blood sugar levels
• High body mass index (BMI)
• Excessive alcohol use
• Low physical activity

Breast cancer patients who are also obese or have type 2 diabetes experience more aggressive cancer growth and worse outcomes. Prior studies have shown that weight loss treatment and surgery following a breast cancer diagnosis are associated with improved heart health and increased survival.

Tips For Maintaining Breast Health

Regular checkups are the cornerstone of early breast cancer detection.

According to the World Health Organization (WHO), early identification of breast abnormalities greatly increases the chances of effective treatment and survival.

• Women who ignore screenings may face delayed diagnosis, which can complicate treatment.
• Schedule regular mammograms and clinical breast exams
• Perform monthly self-examinations
• Know your family medical history
• Maintain a healthy weight and active lifestyle
• Pay attention to hormonal health
• Watch for physical changes such as persistent pain, swelling, or skin dimpling.