Weight loss is usually considered a good thing, unexpected and extreme weight loss can be a sign of something in your body going very wrong. There could be some underlying issues that are causing your body to pull weight and nutrition from your muscles and body fat to keep you going. As you grow old, your limbs grow weaker, and same for your muscles, so you do lose some weight as you age, but losing a lot of it too quickly could be a sign of something much worse, Dementia. A recent study published in JAMA Network Open 2025 Cardiometabolic Trajectories Preceding Dementia in Community-Dwelling Older Individuals, has identified potential early indicators of dementia, including significant weight loss and specific digestive changes, appearing years before noticeable cognitive decline.

The study showed that people who later got dementia had their Body Mass Index, or BMI, go down faster than those who stayed healthy. BMI is a way to see if someone's weight is healthy for their height. This drop in BMI started happening many years before they were told they had dementia, sometimes as early as 11 years ago. Also, these people often started with a lower BMI to begin with. So, even though everyone's weight might change a little as they get older, the people who developed dementia had a much bigger and faster weight loss.

What Are Some Other Indicators Of Dementia?

Along with their BMI, the size of their waist also changed. People who ended up with dementia had smaller waist sizes, and this difference was noticeable about 10 years before they were diagnosed. This means that their bodies were changing in ways that showed up long before they or their doctors noticed any problems. So, not only was there weight loss, but also a loss of abdominal fat. This measurement is important because fat around the waist can be related to other health issues.

The study also found changes in their blood. Specifically, the "good" cholesterol, called HDL, went up in people who developed dementia. This increase happened about five years before they were diagnosed. It's tricky because HDL is usually seen as a good thing for your heart. But in this case, it seems like it might be a sign of changes happening in the brain. Scientists are still trying to understand why this happens.

Weight Loss Doesn’t Cause Dementia, Dementia Causes Weight Loss

When we see that people with dementia lose weight, it's easy to think that the weight loss is what caused dementia. But experts think it's the other way around. They call this "reverse causation." This means that the brain changes that cause dementia also cause people to lose weight. The brain changes can affect things like appetite, how the body uses food, and how people go about their daily lives. For example, people might forget to eat, have trouble making meals, or move around less.

While the study revealed a lot about different indicators of dementia and bodily changes, there are many limitations to the study. Everyone loses some weight as they get older. So, it's hard to know when weight loss is just a normal part of aging and when it's a sign of dementia. The study found that people with dementia lost weight faster, but it's still tricky to tell the difference in everyday life. Doctors need to look at other things, like memory tests, to figure out if someone's weight loss is a cause for concern.

If someone is losing weight without trying, and they're also having problems with their memory or thinking, it's important to talk to a doctor. It's not just about the weight loss; it's about the whole picture.

The NHS has released an alert for people taking a widely prescribed medication used by millions across the UK. Diabetes rates are at an all-time high, with the latest data showing more than 5.8 million people currently living with the condition.

Diabetes UK estimates that around 4.6 million people have already been diagnosed. At the same time, close to 1.3 million people are believed to have Type 2 diabetes without knowing it. The number of cases continues to climb, with figures from 2023–24 showing an increase of 185,034 compared to the previous year.

What Is Metformin Used For?

Metformin is most commonly prescribed for people with Type 2 diabetes. It helps lower and stabilise blood sugar levels and is often the first medicine recommended, alongside changes to diet and physical activity. According to Healthline, it is not used to treat Type 1 diabetes.

What Is Diabetes?

Diabetes is a condition where blood sugar levels become too high. There are three main types. Type 1 diabetes cannot be prevented and is usually diagnosed in childhood. Type 2 diabetes can sometimes be prevented or managed through lifestyle changes such as healthier eating, regular exercise, and weight loss. Gestational diabetes develops during pregnancy. People with Type 1 diabetes need insulin for life, while many with Type 2 or gestational diabetes may manage their condition through lifestyle changes and, in some cases, medication.

Metformin Warning: NHS Issues Alert

The NHS says that people taking metformin should be aware of certain symptoms. Information published on the NHS website lists six common side effects of the medicine. These include:

• feeling sick
• being sick
• diarrhoea
• stomach pain
• loss of appetite
• a metallic taste in the mouth

The NHS also notes that metformin can increase the risk of vitamin B12 deficiency. Some people may experience low blood sugar, but this usually happens only when metformin is taken alongside other diabetes medicines such as insulin or gliclazide.

However, the NHS warns that there are other, more serious side effects. In two situations, patients are advised to contact their GP “straight away,” while one requires calling 999 “now.”

Metformin Serious Side Effects

According to the NHS, serious side effects are uncommon and affect fewer than 1 in 10,000 people. However, medical help should be sought immediately by calling a doctor or dialling 111 if:

you feel generally unwell with extreme tiredness, fast or shallow breathing, feeling cold, and a slow heartbeat

the whites of your eyes turn yellow, or your skin becomes yellow, which may be harder to notice on brown or black skin, as this can indicate liver problems

Metformin Serious Allergic Reaction

In rare cases, metformin can cause a severe allergic reaction known as anaphylaxis. The NHS advises calling 999 immediately if:

• your lips, mouth, throat, or tongue suddenly swell
• you are breathing very quickly or struggling to breathe, including wheezing or feeling as though you are choking
• your throat feels tight or you have difficulty swallowing
• your skin, tongue, or lips turn blue, grey, or pale, which may be easier to spot on the palms or soles in people with darker skin
• you suddenly feel confused, very drowsy, or dizzy
• someone collapses and cannot be woken
• a child becomes limp, floppy, or unusually unresponsive, with difficulty holding up their head or focusing

The NHS adds that you or the affected person may also develop a rash that is swollen, raised, itchy, blistered, or peeling. These signs point to a serious allergic reaction and may require urgent hospital treatment.

The public is being advised to limit close contact with others if they experience flu or Covid symptoms, as the NHS braces for a challenging winter ahead. A mutated, or “drifted”, version of the H3N2 flu strain is fuelling a faster and earlier rise in infections and hospital admissions in 2025. Dr Conall Watson, Consultant Epidemiologist at the UK Health Security Agency, has urged those who are eligible to get vaccinated at the earliest.

He said there are also everyday precautions that can help protect others, especially during the festive season. “If you have symptoms of flu or Covid-19, such as a high temperature, cough, or feeling tired or achy, you should try to reduce contact with other people, particularly those who are more vulnerable. Regular handwashing and good ventilation indoors both make a difference. If you need to go out while unwell, wearing a face covering is worth considering,” he added.

This guidance becomes even more important in the run-up to Christmas, when families tend to gather and older relatives, who face a higher risk of serious illness, are often present.

Flu Symptoms 2025: Less Obvious Symptoms People Often Miss

While many flu symptoms are widely recognised, some are less commonly associated with the illness. The NHS lists ten typical flu symptoms, which often appear suddenly.

Among these, three signs that people may overlook are trouble sleeping, a reduced appetite, and feeling unusually tired or drained. During the busy weeks leading up to Christmas, these symptoms can easily be dismissed as stress or exhaustion rather than flu.

Flu Symptoms 2025: Full List of Common NHS-Listed Signs

The remaining seven symptoms listed by the NHS include a sudden high temperature, body aches, a dry cough, sore throat, headache, diarrhoea or stomach pain, and feeling sick or being sick.

At the same time, the NHS is dealing with added pressure from a surge in winter viruses alongside a five-day strike by resident doctors, previously known as junior doctors. Health leaders and the Government have called on doctors to withdraw the strike, which ministers have described as reckless and irresponsible given the strain on services.

Flu Symptoms 2025: NHS Under Pressure as Winter Challenges Mount

Home Secretary Shabana Mahmood, as per The Independent, said that strikes within the NHS “undoubtedly” put lives at risk. Speaking to Sky News’ Sunday Morning With Trevor Phillips, she said, “We want to ensure the NHS is supported through a difficult winter and this flu outbreak we are currently seeing. It is important that everyone understands what is at stake.”

She also pointed to a difference between the position taken by resident doctors’ leadership and the views of individual doctors, noting that the situation remains sensitive as the NHS navigates one of its most demanding winter periods.

Flu Symptoms 2025: Who Can Still Get Vaccinated?

The NHS provides the flu vaccine free of charge to groups considered most at risk of serious illness. This includes people aged 65 and above, those with certain long-term health conditions, and pregnant women, as per the official NHS website.

The offer also extends to care home residents, carers who look after older or disabled individuals or receive a carer’s allowance, and people living with someone who has a weakened immune system. Frontline health and social care workers are also eligible and can usually receive the vaccine through their employer.

Children are included too. A nasal spray version of the flu vaccine is offered to children aged two and three, as well as school-going children from reception through to year 11.

This is because children tend to catch and spread flu more easily. Vaccinating them not only protects their own health but also helps reduce the risk for vulnerable people around them who could become seriously ill.

Delhi residents continue to struggle with deteriorating air quality, which is taking a visible toll on overall health. The Air Quality Index (AQI) across Delhi NCR crossed 400 on December 15, 2025, placing it firmly in the ‘hazardous’ category. With breathing outdoor air becoming increasingly difficult, many people are turning to air purifiers for relief, both at home and in offices. Yet a common concern persists. Are air purifiers truly safe, or do they come with hidden drawbacks? And can excessive use cause problems of its own? We got in touch with Dr Aditya Nag, Assistant Professor, Department of Respiratory Medicine, NIIMS Medical College and Hospital, to know more about the same.

What Is An Air Purifier?

An air purifier, often referred to as an air filtration system, is designed to clean indoor air by filtering out harmful particles and pollutants. It works by pulling in air from the room, passing it through layers of filters, and releasing cleaner air back into the space. These devices are widely used in homes and offices to create a healthier and more breathable environment.

Also Read: Highly Contagious And Hard To Kill Winter Vomiting Disease Is Spreading In The US, Here's How To Avoid It

Dr Aditya Nag said, “Air purifiers are particularly helpful in removing dust, pollen, pet hair, mould spores, and other microscopic particles that can trigger allergies or worsen respiratory conditions. Their internal filters trap these pollutants, helping improve indoor air quality. In simple terms, they aim to make the air inside cleaner, safer, and easier to breathe.”

Are Air Purifiers Safe To Use?

Air purifiers rely on fans to draw air through one or more filters that capture pollutants before circulating cleaner air back into the room. They come in many forms, from portable units that can be shifted between rooms to wall-mounted models. There are also compact desktop versions and even wearable purifiers available today.

According to our health expert, air purifiers are generally safe and effective at improving indoor air quality, provided the right type is chosen and maintained properly. Models that use True HEPA filters and do not produce ozone are considered the safest. However, ozone-generating purifiers, certain UV-C devices without adequate shielding, and units with poorly maintained filters can release harmful by-products. These secondary pollutants may irritate the lungs and airways. This is why it is important to check safety certifications, replace filters on time, and avoid technologies known to emit ozone.

Overusing Air Purifiers Is Bad For Lungs?

Our expert points out that running an air purifier nonstop on high settings in tightly sealed rooms can reduce indoor humidity levels significantly. This drop in moisture can be uncomfortable for the respiratory system. “While clean air is important, the lungs function best when the air also has enough moisture,” he explains.

Very dry indoor air can irritate the nose, throat, and airways, leading to symptoms such as dryness, scratchy throat, persistent dry cough, burning eyes, and even frequent nosebleeds, especially in the morning.

Dr Nag stresses that air purifiers remain extremely useful, particularly for children, older adults, and people with asthma or allergies. The key is balanced use. He advises switching to auto mode instead of running turbo mode all the time, avoiding completely sealed rooms, and maintaining indoor humidity between 40 and 60 percent. This can be done with a humidifier or simple home measures.

Is It Safe to Sleep Near an Air Purifier?

Many people place air purifiers in their bedrooms, often close to the bed, which raises questions about safety during sleep. According to our expert, sleeping near an air purifier is generally safe and can even be beneficial, as long as basic precautions are followed.

Most modern air purifiers, especially those equipped with HEPA filters, are built for continuous use and operate quietly enough for bedrooms. By reducing allergens and airborne particles overnight, they may help improve sleep quality, particularly for people with allergies or breathing issues.

What To Look For In An Air Purifier?

When choosing an air purifier, it is important to look for models with True HEPA (H13 or H14) filters and activated carbon layers for effective removal of particles and odours. Check whether the purifier is suitable for your room size by reviewing its CADR, or Clean Air Delivery Rate. Noise levels are another key factor, especially if the device will be used in a bedroom.

It is also wise to consider the cost and frequency of filter replacement. Be cautious of purifiers that rely on ozone-producing ionisers or certain UV features. A reliable air purifier should offer multi-stage filtration, cover the intended space efficiently, and operate quietly without compromising safety.