Weight loss is usually considered a good thing, unexpected and extreme weight loss can be a sign of something in your body going very wrong. There could be some underlying issues that are causing your body to pull weight and nutrition from your muscles and body fat to keep you going. As you grow old, your limbs grow weaker, and same for your muscles, so you do lose some weight as you age, but losing a lot of it too quickly could be a sign of something much worse, Dementia. A recent study published in JAMA Network Open 2025 Cardiometabolic Trajectories Preceding Dementia in Community-Dwelling Older Individuals, has identified potential early indicators of dementia, including significant weight loss and specific digestive changes, appearing years before noticeable cognitive decline.

The study showed that people who later got dementia had their Body Mass Index, or BMI, go down faster than those who stayed healthy. BMI is a way to see if someone's weight is healthy for their height. This drop in BMI started happening many years before they were told they had dementia, sometimes as early as 11 years ago. Also, these people often started with a lower BMI to begin with. So, even though everyone's weight might change a little as they get older, the people who developed dementia had a much bigger and faster weight loss.

What Are Some Other Indicators Of Dementia?

Along with their BMI, the size of their waist also changed. People who ended up with dementia had smaller waist sizes, and this difference was noticeable about 10 years before they were diagnosed. This means that their bodies were changing in ways that showed up long before they or their doctors noticed any problems. So, not only was there weight loss, but also a loss of abdominal fat. This measurement is important because fat around the waist can be related to other health issues.

The study also found changes in their blood. Specifically, the "good" cholesterol, called HDL, went up in people who developed dementia. This increase happened about five years before they were diagnosed. It's tricky because HDL is usually seen as a good thing for your heart. But in this case, it seems like it might be a sign of changes happening in the brain. Scientists are still trying to understand why this happens.

Weight Loss Doesn’t Cause Dementia, Dementia Causes Weight Loss

When we see that people with dementia lose weight, it's easy to think that the weight loss is what caused dementia. But experts think it's the other way around. They call this "reverse causation." This means that the brain changes that cause dementia also cause people to lose weight. The brain changes can affect things like appetite, how the body uses food, and how people go about their daily lives. For example, people might forget to eat, have trouble making meals, or move around less.

While the study revealed a lot about different indicators of dementia and bodily changes, there are many limitations to the study. Everyone loses some weight as they get older. So, it's hard to know when weight loss is just a normal part of aging and when it's a sign of dementia. The study found that people with dementia lost weight faster, but it's still tricky to tell the difference in everyday life. Doctors need to look at other things, like memory tests, to figure out if someone's weight loss is a cause for concern.

If someone is losing weight without trying, and they're also having problems with their memory or thinking, it's important to talk to a doctor. It's not just about the weight loss; it's about the whole picture.

Water remains the most reliable and effective way to keep the body hydrated during hot weather. However, many people increasingly turn to energy drinks during long workdays or busy schedules, hoping to stay refreshed or energized.

Experts warn that relying on these drinks instead of water can create several health risks, particularly when temperatures are high.

Energy drinks are typically marketed as quick solutions for fatigue and low energy. They often contain high levels of caffeine, added sugars and stimulants that may temporarily increase alertness.

While this short term boost may seem appealing, experts say these drinks are not designed to support proper hydration. When consumed frequently, especially during summer, they can place extra strain on the body rather than helping it stay cool and hydrated.

Dr Arun Sachdeva, an Internal Medicine Specialist at Felix Healthcare in Bengaluru, explains that replacing water with energy drinks during hot weather can interfere with the body’s natural hydration balance.

According to him, excessive consumption of these beverages may contribute to both immediate and long term health concerns, particularly when the body is already losing fluids through sweating.

Higher Risk Of Dehydration

During summer, when sweating already causes significant water loss, this effect may make it harder for the body to maintain proper hydration.

When energy drinks replace water intake, the risk of dehydration increases. Common symptoms of dehydration include fatigue, dizziness, headaches and dry mouth. In more severe cases, dehydration can also affect concentration, physical performance and overall wellbeing.

Excessive Stress On The Heart

For people who already have high blood pressure or existing heart conditions, excessive intake of energy drinks could increase the risk of heart palpitations or irregular heart rhythms. Experts therefore recommend limiting the consumption of these beverages, particularly during periods of intense heat.

High Sugar And Empty Calories

Frequent spikes in blood sugar levels may gradually increase the risk of metabolic disorders. Over time, consistently high sugar consumption can contribute to health problems such as obesity and type 2 diabetes.

Therefore, doctors advise paying attention to sugar content in beverages, especially during hot weather when people tend to drink more fluids throughout the day.

Sleep Disruption And Energy Crashes

Instead of providing sustained energy, regular consumption of energy drinks may lead to temporary stimulation followed by sudden drops in energy levels.

This cycle can leave individuals feeling even more tired later in the day, creating a pattern where they rely on more caffeinated drinks to stay alert.

Kidney Health And Hydration

When the body does not receive enough water, the kidneys may struggle to function efficiently. Over time, poor hydration can increase the risk of kidney related problems and may affect the body’s ability to regulate fluid levels effectively.

Why Water Remains The Best Choice

Doctors emphasize that water remains the safest and most effective drink for maintaining hydration during summer. It helps regulate body temperature, supports organ function and replaces fluids lost through sweating without introducing excess caffeine, sugar or stimulants.

Energy drinks may occasionally provide a quick boost of alertness, but they should not be used as a substitute for water. Maintaining regular water intake throughout the day remains one of the simplest and most effective ways to support overall health during hot weather.

Late nights at the office, quick dinners made from instant noodles or packaged snacks and constant deadline pressure are often treated as normal parts of professional life, but doctors say these habits may gradually affect kidney health.

Nephrologists report that routine health screenings are increasingly detecting early signs of kidney stress in people in their late 20s to 30s, even among those without traditional risk factors such as diabetes, smoking or a family history of kidney disease.

According to nephrologist Dr Kristin George, some patients show warning indicators such as elevated creatinine levels, high blood pressure or traces of protein in the urine.

Creatinine is a waste product filtered out by the kidneys and rising levels may indicate that the organs are not removing waste as efficiently as they should.

Doctors say that when lifestyle patterns are examined more closely, prolonged work stress, sedentary routines, irregular meals and frequent late-night snacking often emerge as common factors.

Kidney Disease Is A Growing Global Concern

Chronic kidney disease, or CKD, involves the gradual loss of kidney function over time and can eventually lead to kidney failure if it is not detected early.

Health experts warn that CKD could become one of the leading causes of death globally in the coming decades. Diabetes and hypertension account for a large proportion of cases and according to the International Society of Nephrology these two conditions combined contribute to nearly two-thirds of chronic kidney disease cases worldwide.

Doctors also note that prolonged stress may indirectly increase these risks because long-term elevations in stress hormones such as cortisol can raise blood pressure and disrupt metabolic balance.

Processed Foods And Late-Night Eating

Late-night meals frequently include instant noodles, chips, processed meats or packaged snacks, many of which contain significant amounts of sodium.

Sodium helps regulate fluid balance, but excessive intake forces the kidneys to work harder to maintain stable blood pressure. The World Health Organization estimates that most adults consume nearly twice the recommended daily sodium intake, largely because of processed foods.

Doctors say that consistently high salt intake can gradually increase blood pressure and place additional strain on kidney function.

Sedentary Work And Poor Hydration

Hydration habits and prolonged sitting are additional concerns among office workers. Many professionals rely heavily on coffee, energy drinks or sugary beverages during long workdays, often replacing plain water as the main source of fluid intake.

While moderate caffeine consumption is generally considered safe, relying mainly on caffeinated drinks can contribute to mild dehydration, which may affect blood circulation through the kidneys and increase the likelihood of kidney stones.

At the same time, many corporate jobs require employees to remain seated for extended periods. Sedentary routines have been linked to obesity, impaired glucose metabolism and high blood pressure, all of which are major contributors to kidney disease.

Early Signs Often Go Unnoticed

Kidney disease often develops silently in its early stages, which means many people remain unaware of the problem until significant damage has occurred.

Early kidney dysfunction may progress quietly for years before symptoms appear, and by the time signs such as swelling, fatigue or changes in urination become noticeable, kidney function may already be reduced.

Doctors therefore recommend periodic screening tests, including serum creatinine measurements, estimated glomerular filtration rate (eGFR) tests and urine albumin tests, which can detect early signs of kidney damage.

Small Changes Can Make A Difference

Health experts say that protecting kidney health often begins with small lifestyle changes. Reducing processed food consumption, limiting excessive salt intake, staying adequately hydrated and maintaining regular sleep schedules can all support kidney function.

Taking short movement breaks during long work hours and managing stress through regular physical activity or relaxation techniques may also help reduce the long-term strain that modern work routines place on the body.

Doctors emphasise that kidney disease usually develops gradually, which means recognising and adjusting everyday habits early may help many young professionals protect their kidney health.

Heart disease remains the leading cause of death in India, often affecting people nearly a decade earlier than in Western populations.

Recent cholesterol management recommendations from the American Heart Association (AHA) and related global guidelines emphasize aggressive control of LDL cholesterol — the so-called “bad cholesterol.” For Indians, these recommendations carry particular importance.

Studies consistently show that South Asians have a higher tendency for premature coronary artery disease. Even individuals who appear relatively lean may have underlying metabolic risk factors such as insulin resistance, abdominal obesity, and elevated triglycerides. Because of this inherent susceptibility, the same cholesterol levels that may appear “borderline” in Western populations can translate into a significantly higher cardiovascular risk in Indians.

What Does The New Guidelines Say

The newer guidelines shift the focus away from merely treating cholesterol numbers to assessing an individual’s overall cardiovascular risk.

Factors such as diabetes, smoking, blood pressure, family history of early heart disease, and age are considered together. If a person falls into a higher-risk category, doctors now recommend lowering LDL cholesterol more aggressively than before.

For people who already have established heart disease, the goal is particularly strict. LDL cholesterol is ideally reduced to levels below 55 mg/dL. Achieving such targets often requires not only lifestyle changes but also medications such as statins, and in some cases, newer therapies that further lower cholesterol levels.

How Indians Can Prevent Heart Disease

For Indians without diagnosed heart disease, prevention becomes the key message. Regular screening after the age of 30–35 years is increasingly advisable, especially if there is a family history of heart disease or diabetes. Diet also plays a central role: reducing trans fats, limiting refined carbohydrates, increasing fibre intake, and maintaining a healthy body weight can significantly influence cholesterol levels.

Equally important is regular physical activity. Even 30 minutes of brisk walking most days of the week can improve lipid profiles and reduce cardiovascular risk.

The key takeaway is simple: Indians develop heart disease earlier and often at lower cholesterol levels.

The newer AHA recommendations reinforce the need for earlier screening, individualized risk assessment, and more proactive cholesterol management to prevent future heart attacks.