Sleep changes as we age. When we were kids, we needed 10 to 12 hours of sleep, for teens it is eight to 10 and it decreases to seven to nine as we reach adulthood. But there is always a lack of urgency when it comes to sleep and young adults, many of whom prefer staying up and doing different activities. According to the Centre of Disease Control and Prevention, many national surveys show that about 37% of men, and 39% of people from the age of 45 to 64 reported not getting enough sleep.

Many people in America don't sleep the right amount. This means they either sleep too long or not long enough. But what happens to your body when you do not sleep enough? You just feel tired right? No, when you don't get this much sleep, your body can get stressed. This can make you more likely to get sick. A study published by the JAMA Network Open Sleep Trajectories and All-Cause Mortality Among Low-Income Adults showed that people who don't sleep the right amount have a higher chance of dying early. It's like your body needs that time to rest and fix itself. Without enough good sleep, things can start to go wrong. So, getting the right amount of sleep is super important for staying healthy.

How Was The Study Done?

Scientists wanted to see how sleep habits affect people's health over many years. They looked at almost 47,000 people who were between 40 and 79 years old. They asked them about their sleep habits when the study started, and then again, a few years later. The scientists wanted to see if people's sleep habits changed. They divided people into groups based on if they started with too much or too little sleep, and if their sleep changed over time. For example, some people started sleeping a lot but then started sleeping very little. This helped the scientists see how different sleep patterns affected people's health. They wanted to see the long-term effects of sleep.

The study found that people who had sleep habits that changed a lot had a higher risk of dying early. This means if you started sleeping too much and then switched to sleeping too little, or the other way around, you were more likely to die sooner. They also found that these people had a higher risk of heart problems. The risks were even higher for some groups of people, like white adults and people with higher incomes.

Sleep Deprivation And Its Effect On The Body

If you often doze off when you are sitting and reading, watching a movie, talking to someone, sitting quietly after lunch or even during a few minutes of traffic, you may be sleep deprived according to the National Heart, Lung, and Blood Institute. They explain how sleep deprivation can cause issues with learning, focusing and reacting to certain things. The symptoms of sleep deprivation in kids differ a little as they might be overly active and have trouble paying attention to certain things. If you are experiencing sleep issues, make sure to speak to a healthcare professional who will help you identify the issues and direct you towards the treatment or changes you must make. Here are some ways sleep helps your body.

Repairs Your Heart

Good sleep allows your heart and blood vessels to heal. This keeps them strong and healthy, reducing the risk of heart problems.

Controls Hunger

Sleep helps balance your hunger hormones, so you don't feel too hungry. This helps prevent eating too much and keeps your weight healthy.

Manages Blood Sugar

Proper sleep helps your body use insulin correctly. This lowers the chance of high blood sugar, which can lead to diabetes.

Supports Growth

Deep sleep releases growth hormones, helping kids and teens grow. It also repairs body tissues, which is important for everyone.

Boosts Immunity

When you sleep well, your body's defense system gets stronger. This helps you fight off germs and stay healthy.

For all major diseases, early detection is key to improving treatment outcomes. However, when it comes to rare diseases, it is unpredictable, making it more challenging to diagnose. In such a scenario, Artificial Intelligence (AI) is playing a major role -- from early diagnosis to treatment, said health experts on Rare Disease Day.

Rare Disease Day is annually observed on February 28 to raise awareness about the lesser-known conditions and the underlying challenges for people suffering from them.

While many of the rare disorders are genetic, they often also surface without any prior family history. In some cases, they are diagnosed in infancy, while in others the manifestation is years late.

The advanced AI technology is, however, now enabling clinicians to better understand the patients’ genetic profiles and patterns that were not clearer earlier. The technology is also paving the way for earlier and more accurate diagnoses, bringing hope to thousands of patients worldwide.

“AI is revolutionizing the fight against rare diseases by speeding up diagnosis, research, and development of treatments. Rare diseases often take years to diagnose because of the lack of data, overlapping symptoms, and unclear diagnosis,” Dr. Vinit Banga, Director, Neurology, Fortis Escorts Hospital, Faridabad, told HealthandMe.

“AI algorithms can process medical records, genetic information, and images to identify patterns that may escape human detection, allowing for earlier and more accurate diagnoses,” he added.

AI Simplifying Rare Disease Diagnoses, Drug development

In a February paper published in the journal Nature, researchers from the Shanghai Jiao Tong University in China presented an AI system called DeepRare -- a multi-agent system for rare disease differential diagnosis decision support, powered by large language models, integrating more than 40 specialized tools.

Using the specialized tools and knowledge sources, the agentic AI system generates ranked diagnostic hypotheses for rare diseases. Each of the tools was also accompanied by reasoning that links the conclusions to verifiable medical evidence.

Similarly, Harvard University-based researchers in a paper also published in the Nature journal in 2025 described an AI tool called PopEVE, which can identify genetic variants most likely to cause severe disease or death.

The model was able to identify more than 100 novel alterations responsible for undiagnosed, rare genetic diseases.

"AI is cutting short the diagnostic odyssey from years to weeks. Large-scale genomic projects help create a vital reference architecture for India and the global community,” Dr. Sudheendra Rao N R, MBBS, PhD, Scientific Advisor, Organization for Rare Diseases India, told HealthandMe.

By integrating deep phenotyping with AI, clinicians can decipher unknown genetic variants and accelerate the development of both repurposed and next-generation precision-therapies, the expert added.

AI can also help researchers identify new drug targets for the treatment of rare conditions.

Dr. Banga said that AI is also instrumental in accelerating drug development by processing enormous amounts of biomedical data to discover new targets for drugs and repurpose existing ones. Importantly, AI is cutting down on time and expenses.

“Machine learning algorithms enable the prediction of patient responses to particular treatments, making it possible to develop personalized treatment strategies,” the expert said.

Further, AI-enabled infrastructure is helping to achieve geographic neutrality, delivering the same caliber of healthcare screening to rural villages and Tier-3 cities as to Tier-1 hubs, ensuring a high-quality healthcare gateway that is no longer defined by where the patient lives.

Moreover, AI-based platforms bring together researchers from across the globe, making it easier to share data.

What Is A Rare Disease

The World Health Organization (WHO) defines a rare disease as an often debilitating, chronic, or degenerative condition affecting 1 or fewer per 1,000 population.

Rare diseases do not have epidemiological data, are at high risk of misdiagnosis, and often also lack effective treatments.

According to the WHO ICD-11 (International Classification of Diseases), there are over 5,500 rare diseases. It also assigns unique identifiers (URIs) to them for better tracking.

There are estimated to be over 7,000 distinct rare diseases affecting more than 300 million people globally.

Do you know that congenital hypothyroidism, a rare disability, affects about 1 in 2,500–3,000 newborns globally, but in India, the incidence is higher -- approximately 1 in 1,000 births.

India records nearly 26 million births annually, with an estimated 10,000 babies born each year with Congenital Hypothyroidism.

This means 27 babies are born every day in India, with the condition that more than one is born every hour. Early treatment within the first 2 weeks of life can ensure normal brain development, while delayed treatment can reduce IQ by 30–50 points.

Congenital Hypothyroidism (CH) is a condition present at birth in which a baby’s thyroid gland does not produce enough thyroid hormone.

The thyroid is a small gland located in the neck. It produces a hormone called thyroxine (T4), which is essential for brain development, growth, and overall body metabolism. The thyroid hormone is especially important in the first few weeks of life.

The thyroid hormone helps in:

• Brain development
• Physical growth
• Bone development
• Muscle strength
• Energy regulation

If a baby does not receive enough thyroid hormones soon after birth, it can lead to permanent intellectual disability and growth problems.

The good news is that congenital hypothyroidism is easily detectable and completely treatable if identified early.

What Causes Congenital Hypothyroidism? What Are The Symptoms?

Congenital Hypothyroidism may occur because:

• The thyroid gland is completely absent
• The thyroid gland is underdeveloped
• The gland is present but does not function properly
• Rarely, the baby cannot produce or use the thyroid hormone correctly

One of the biggest challenges with Congenital Hypothyroidism is that most babies look completely normal at birth.

However, over time, some signs may appear:

• Excessive sleepiness
• Poor feeding
• Constipation
• Prolonged jaundice (yellowing of skin and eyes)
• Hoarse cry
• Large tongue
• Puffy face
• Cold or dry skin
• Slow growth

How Is Congenital Hypothyroidism Detected?

1. Newborn Screening Test (Heel-Prick Test)

• This is the most important test.
• A few drops of blood are taken from the baby’s heel.
• It is usually done 48–72 hours after birth, but can be done soon after birth on the cord blood, too.
• Test measures Thyroid Stimulating Hormone (TSH).
• If TSH levels are high, it suggests that the thyroid is not functioning properly.
• This test is simple, safe, quick, and affordable

2. Confirmatory Blood Tests

If the screening test is abnormal, the doctor will order:

• Serum TSH test
• Free T4 (thyroxine) level
• High TSH and low T4 confirm the diagnosis

3. Thyroid Scan

In some cases, imaging tests are needed. The ultrasound of the neck (less accurate) and Nuclear Medicine Thyroid scan (more accurate) may be done to check whether the gland is absent, small, or misplaced. However, treatment should not be delayed while waiting for imaging.

When Should Treatment Start?

Treatment should begin as early as possible -- ideally within the first 14 days of life. Starting treatment within the first two weeks allows normal brain development.

Delaying treatment increases the risk of permanent intellectual disability.

Doctors will monitor:

• TSH levels
• T4 levels
• Baby’s growth and development

Initially, blood tests are done every 2–4 weeks, then less frequently as the child grows. Proper follow-up ensures the dose remains correct. Some babies may need treatment for life.

In certain cases, doctors may reassess thyroid function after 3 years of age to see whether the condition is temporary or permanent. Most children who receive early and proper treatment grow up with completely normal intelligence and physical development.

Can Congenital Hypothyroidism Be Prevented? Why Early Screening Is So Important

Most cases cannot be prevented. However:

• Universal newborn screening can prevent intellectual disability
• Ensuring adequate iodine intake during pregnancy helps reduce risk
• The key is early detection—not prevention

A baby with Congenital Hypothyroidism may look perfectly healthy. Without screening, diagnosis may be delayed until symptoms appear—by then, brain development may already be affected.

With early testing the diagnosis is simple; treatment is affordable; and outcome is excellent. But without testing:

• Intellectual disability can occur
• Growth may be affected
• The child may require lifelong support

Congenital Hypothyroidism is one of the most preventable causes of intellectual disability in children. A small heel-prick test in the first few days of life can protect your baby’s brain forever.

If you are expecting a baby or have a newborn, speak to your doctor about newborn thyroid screening.

Early diagnosis. Simple treatment. Normal life.

Prime Minister Narendra Modi today launched the nationwide Human Papillomavirus (HPV) vaccination campaign for girls aged 14 years from Rajasthan's Ajmer.

The initiative marks a decisive step towards eliminating cervical cancer through timely HPV vaccination. Cervical cancer remains the second most common cancer among women in India. Nearly 80,000 new cases and over 42,000 deaths are reported annually in the country.

"Today, I have had the opportunity to launch the HPV vaccine campaign from Ajmer. This campaign is an important step towards empowering women and daughters of this country,” PM Modi said.

“For us, this was a sensitive issue tied to the insult of our sisters and daughters, one that made them ill. That is why we resolved it at a crucial turning point in their mission,” he added.

The World Health Organization has also lauded India's mission to launch the HPV vaccine and prevent the risk of cervical cancer.

“We are leaving no stone unturned to ensure that the daughters of the country are healthy and prosperous. The objective of this initiative is the prevention of cervical cancer," the Prime Minister, earlier wrote in a post on social media platform X.

The HPV Vaccination Campaign

The nationwide program, based on expert recommendations of the National Technical Advisory Group on Immunization (NTAGI), will target girls aged 14 years.

At 14, the HPV vaccine offers maximum preventive benefit, well before potential exposure to the virus.

"By prioritizing prevention at the right age, the program is expected to provide lifelong protection and significantly reduce the future burden of cervical cancer in the country," the government said.

“The HPV vaccine works best at 9-14 years, before exposure, and when the immune response is strongest. Studies show effectiveness is highest in younger age groups and decreases with age,” Dr. Parmod Kumar, Associate Professor in Medical Oncology, AIIMS Jodhpur, shared on X.

Vaccination under the national program will be voluntary and free of cost.

The HPV vaccination will be conducted exclusively at designated government health facilities, including Ayushman Arogya Mandirs (Primary Health Centers), Community Health Centers, Sub-District and District Hospitals, and Government Medical Colleges.

Cervical Cancer Burden In South East Asia

Despite being preventable, cervical cancer continues to claim the life of a woman every two minutes globally, and the WHO South-East Asia Region bears nearly one-quarter of the global burden.

Dr. Catharina Boehme, Officer-in-Charge, WHO South-East Asia, stated that the introduction of HPV vaccination at a national scale in India "will have a far-reaching impact". It will accelerate progress not only for the country, but for the region and the world, she said.

“This landmark step, led at the highest level of government, reflects India’s strong commitment to protecting adolescent girls from cervical cancer," said Dr. Boehme.

With today’s milestone, nine of the 10 countries in the Region now include HPV vaccination in their national immunization programs.

The WHO global targets for 2030 include vaccinating 90 percent of girls by age 15, screening 70 percent of women by ages 35 and 45, and ensuring 90 percent of women with pre-cancer and invasive cancer receive appropriate treatment.