Many of us may have taken ibuprofen, sometimes two pills at once, especially when we are struggling with menstrual cramps. Well, as good these pills may be in treating the pain, they are not recommended for your health, especially if you are someone who consumes it on a daily basis or frequently. Gastroenterologist Trisha Pasricha, MD, writes in The Washington Post about why should you avoid taking nonsteroidal anti-inflammatory drugs, or NSAIDs, such as ibuprofen, naproxen and aspirin.

What happens when you consume pain killers?

She writes that NSAIDs are great in treating short term pain. They comprise of a group of drugs that inhibit the production of prostaglandins, which serve as a variety of purposes in the body. Some of which also includes contracting the uterus during menses and regulating blood flow in our vessels.

While one to two doses every now and then is okay, following a regular dosage routine, which could range from several times a month, or twice in an hour or so could lead to health risk. NSAIDs are well known to increase intestinal permeability. This means, these painkillers could damage the lining of your gut.

A 2018 review by Ingvar Bjarnason et. al., also writes about how NSAIDs can reduce the blood flow in the tiny vessels that feeds our guts. It can also disrupt the intestinal cells forming a barrier between the outside world and your insides.

What can be done?

While people with conditions like migraines, chronic back pain or bad period cramps can find NSAIDs to be helpful. It is always advisable to have a chat with your physicians to explore NSAID alternatives.

Pasricha suggests acetaminophen.

However, if someone is in dire need of NSAID, her tip is to take the pill right at the start of your symptoms. She says that the drug can do a far better job at stopping things at the source than chasing after all prostaglandins.

Why is it a concern?

NSAIDs are available as over the counter drug, which means people do not need a prescription for it and can make medical decision about them without the guidance of a physician.

A 2018 study published in the Official Journal of the International Society for Pharmacoepidemiology by David W Kaufman, et.al., found that 15% of adult ibuprofen users in the US have exceeded the maximum recommended daily dose. The study also mentions that more than a third of ibuprofen users were taking other NSAIDs, like aspirin and naproxen, while consuming ibuprofen at the same time. Out of these, 61% did not realise that they were using NSAIDs.

Pasricha talks about how it ruptures the gut wall, as she herself has rushed to the hospital in the middle of the night "far more times than" she can count "to perform an emergency endoscopy on someone who was bleeding profusely from an ulcer caused by NSAID".

Another 2009 study published in the American Journal of Gastroenterology states that as many as 1 in 4 chronic NSAID users will get an ulcer and about 4% will bleed or rupture through the gut wall.

An older study from 2005 titled A quantitative analysis of NSAID-induced small bowel pathology by capsule enteroscopy, found that as 75 percent of people regularly using NSAIDs develop low-grade inflammation in their small bowels. NSAIDs can also lead to development of fatty liver disease. This happens because your gut lining becomes more permeable, more toxins and bacteria from the outside world enters your liver and leads to inflammation.

A 2011 study titled Haemoglobin decreases in NSAID users over time: an analysis of two large outcome trials, states that as many as 6% of people taking NSAIDs regularly have found their blood count dropping within a few months of starting the medicines, this suggests that this is due to the small, slow amount of bleeding in the gut overtime.

When people think of Alzheimer's specifically, memory loss is usually the first thing that comes to mind — forgetting recent conversations, repeating questions, struggling to recall familiar names. But Alzheimer's rarely announces itself through memory alone. It can also show up in how a person communicates, makes decisions, behaves, and manages the everyday tasks that once came naturally. People often mistake dementia and Alzheimer's for the same thing; however, dementia is not a single disease but a broad term for a decline in memory, thinking, and reasoning severe enough to interfere with daily life. Alzheimer's disease is the most common cause of dementia, accounting for a majority of cases.

Signs Families Often Misread

These early changes are easy to misattribute. A person who withdraws from social life may seem to be "losing interest." Someone who grows irritable may be written off as difficult or set in their ways. A family member who lets bills slide may appear distracted rather than unwell. Only when such shifts persist and clearly depart from a person's usual character do they warrant closer attention.

Communication And Language

Difficulty finding a familiar word now and then is normal. But losing the thread of a conversation, or struggling to express thoughts that once came easily, is different — and when this worsens over time, it's often family and friends who notice first.

Judgement And Everyday Decision-Making

Independence can erode quietly. Someone who has handled the household finances for decades may start making uncharacteristic decisions or find bills confusing. Following a familiar recipe, managing medication schedules, or planning a routine outing may become surprisingly hard. Family members frequently pick up on these lapses in judgement before they notice any memory trouble at all.

Behaviour And Personality

A once-sociable person may pull back from hobbies and company. Others may become anxious, suspicious, or emotionally distant in ways that feel out of character. These shifts can be hard for loved ones to make sense of — especially when they seem intentional — but they often reflect real changes in how the brain is processing and responding to the world, not a change in who someone chooses to be.

Daily Functioning

There's a meaningful difference between misplacing your keys occasionally and repeatedly leaving objects in strange places with no memory of how they got there. Likewise, forgetting one appointment is ordinary; missing commitments again and again despite reminders is not. Trouble navigating familiar streets, preparing a simple meal, or keeping up with personal care can point to a broader change in cognitive function.

Not A Diagnosis In Itself

None of these changes automatically means Alzheimer's. Many have other causes — some of them treatable — which is exactly why a medical assessment matters: it helps identify what's actually going on and whether further evaluation is needed.

What helps: Patterns, Not Incidents

For families, tracking patterns is far more useful than reacting to isolated moments. When did the changes start? How often do they happen? Are they starting to affect independence? This kind of observation gives doctors much more to work with than a single anecdote.

How families respond matters too. Correcting or criticising someone for changes they can't control tends to breed frustration on both sides. A patient, supportive approach protects their dignity while making it easier to get them the care they need.

Alzheimer's, in short, is not only a disease of memory. Its earliest clues can surface in conversation, judgement, behaviour, or the small routines of daily life. Recognising these signs isn't about assuming the worst — it's about noticing when something is genuinely different, and knowing when that difference is worth a doctor's opinion.

By Dr. Tanushree Chawla, Neurologist, PB Health

For decades, childhood vaccination was one of the clearest public health success stories in Europe. But a new study published in The Lancet Regional Health—Europe, suggests that progress has started to slip, and in some countries, it has slipped quite noticeably.

The research led by a team from the Università Cattolica del Sacro Cuore in Rome looked at vaccination coverage across seven different vaccines in European Union countries, tracking data all the way from 1980 to 2024. What it found was not a sudden collapse, but something arguably more concerning: a slow, steady stall that has crept in over the last few years without much attention.

Which Childhood Vaccine Rates Dropped?

According to the research, recent declines were most widespread for vaccines against

• Hemophilus influenzae type b
• polio,
• hepatitis B
• diphtheria-tetanus-pertussis.

Where the Decline Is Happening

Since 2019, sixteen countries have seen vaccination rates drop for four or more of the vaccines studied. Bulgaria, Cyprus, Ireland, the Netherlands, Romania, and Sweden stood out in particular, with all seven vaccines showing a downward trend in recent years.

The pattern wasn't uniform everywhere, though. Germany and Spain saw declines in five of the seven vaccines, while France and Italy told a more mixed story, with four vaccines improving even as three others slipped.

At the higher end, Luxembourg and Portugal managed to maintain at least 95 percent coverage across all seven vaccines, a benchmark most countries are still trying to reach. Romania, on the other hand, fell below 80 percent, making it the lowest performer in the study.

Why This Is Happening Now

According to the researchers, the timing of this decline is not a coincidence. Most of it began somewhere between 2019 and 2022, a period that overlaps almost exactly with the Covid-19 pandemic and its aftermath. Routine vaccination services were widely disrupted during that time, and the study suggests that many countries simply haven't fully recovered since.

There's also a broader factor at play: vaccine hesitancy, which researchers describe as a growing contributor to the decline, separate from any pandemic-related disruption. In other words, this isn't only about missed appointments during lockdowns. It also reflects a shift in how some parents and communities are approaching vaccination altogether.

What This Means Going Forward

Vaccination remains one of the most effective tools available for preventing serious childhood diseases, and researchers are clear about what's at stake if this trend continues. A sustained drop in coverage doesn't just affect individual children; it also weakens herd immunity, making entire communities more vulnerable to diseases that had largely been kept under control for years.

The study was direct about what needs to happen next, stating that international, national, and community-level action will be necessary to reverse these trends. Without it, the progress that took decades to build could continue to erode, quietly, one missed vaccination at a time.

Think being in great shape and having a “normal” BMI gives men a good shot at fertility? Think again.

While fertility is usually seen as a women's issue, it's increasingly becoming a men's problem too. Sperm counts worldwide have dropped by more than half since 1973, and the decline has been speeding up in recent years. Now, a new study in Denmark just found something that should worry a lot of men.

Researchers looked at over a thousand young men and measured their actual body fat, not just their BMI. What they found was surprising. Men with a "normal" BMI but slightly higher body fat had noticeably lower sperm counts than leaner men in the same weight range.

The Numbers Don't Lie

Men with 20 to 24 percent body fat had sperm counts that were 23 percent lower than the leanest group. This gap showed up even among men who were considered to be of normal weight.

In other words, you could look completely fine, weigh the "right" amount for your height, and still be carrying extra fat that's actually messing with your hormones.

That's because body fat doesn't just sit there. It changes your hormone levels. The study, published in the journal Human Reproduction, found higher body fat was linked to lower testosterone, along with shifts in a few other hormones tied to reproduction.

“Higher body fat percentage was associated with poor semen characteristics and impaired reproductive hormone levels but not with testicular volume,” said the team from Aarhus University, Denmark.

The researchers noted that a higher percentage of adipose tissue might adversely affect semen production and hormonal balance.

Why Muscle Might Matter More Than Weight

It may not really be about losing weight at all. Other studies focus on muscle weight. Muscles may not be just something that makes you look good; they actually work like a hormone-producing organ in your body.

A 2025 study published in Frontiers in Endocrinology examined 823 semen analyses and concluded that assessing fat distribution, rather than obesity alone, could provide additional information about male reproductive health.

So for men thinking about having kids someday, hitting the gym and building muscle might do more for fertility than just watching the number on the scale go down.

What About Weight-Loss Drugs?

Even as many people now are on GLP-1 drugs like Ozempic and Wegovy for weight loss, the question is: do these drugs help or hurt fertility? The early research is actually reassuring.

A review presented at recent ENDO 2026 examined five randomized clinical trials and found no bad effects on hormones, sex drive, or sperm quality in men taking these drugs. However, doctors are worried about men who lose weight too fast and lose muscle along with the fat.

Other Factors That Can Affect Sperm Health

Body composition is only one factor linked to male reproductive health. Lifestyle factors such as smoking, heavy alcohol use, cannabis use, obesity and anabolic steroid use have also been associated with poorer sperm health.

Heat exposure may also affect sperm production. Regular use of saunas and hot tubs has been studied as a potential risk factor, while prolonged heat exposure from devices such as laptops placed directly on the lap has also raised concerns.