Many of us may have taken ibuprofen, sometimes two pills at once, especially when we are struggling with menstrual cramps. Well, as good these pills may be in treating the pain, they are not recommended for your health, especially if you are someone who consumes it on a daily basis or frequently. Gastroenterologist Trisha Pasricha, MD, writes in The Washington Post about why should you avoid taking nonsteroidal anti-inflammatory drugs, or NSAIDs, such as ibuprofen, naproxen and aspirin.

What happens when you consume pain killers?

She writes that NSAIDs are great in treating short term pain. They comprise of a group of drugs that inhibit the production of prostaglandins, which serve as a variety of purposes in the body. Some of which also includes contracting the uterus during menses and regulating blood flow in our vessels.

While one to two doses every now and then is okay, following a regular dosage routine, which could range from several times a month, or twice in an hour or so could lead to health risk. NSAIDs are well known to increase intestinal permeability. This means, these painkillers could damage the lining of your gut.

A 2018 review by Ingvar Bjarnason et. al., also writes about how NSAIDs can reduce the blood flow in the tiny vessels that feeds our guts. It can also disrupt the intestinal cells forming a barrier between the outside world and your insides.

What can be done?

While people with conditions like migraines, chronic back pain or bad period cramps can find NSAIDs to be helpful. It is always advisable to have a chat with your physicians to explore NSAID alternatives.

Pasricha suggests acetaminophen.

However, if someone is in dire need of NSAID, her tip is to take the pill right at the start of your symptoms. She says that the drug can do a far better job at stopping things at the source than chasing after all prostaglandins.

Why is it a concern?

NSAIDs are available as over the counter drug, which means people do not need a prescription for it and can make medical decision about them without the guidance of a physician.

A 2018 study published in the Official Journal of the International Society for Pharmacoepidemiology by David W Kaufman, et.al., found that 15% of adult ibuprofen users in the US have exceeded the maximum recommended daily dose. The study also mentions that more than a third of ibuprofen users were taking other NSAIDs, like aspirin and naproxen, while consuming ibuprofen at the same time. Out of these, 61% did not realise that they were using NSAIDs.

Pasricha talks about how it ruptures the gut wall, as she herself has rushed to the hospital in the middle of the night "far more times than" she can count "to perform an emergency endoscopy on someone who was bleeding profusely from an ulcer caused by NSAID".

Another 2009 study published in the American Journal of Gastroenterology states that as many as 1 in 4 chronic NSAID users will get an ulcer and about 4% will bleed or rupture through the gut wall.

An older study from 2005 titled A quantitative analysis of NSAID-induced small bowel pathology by capsule enteroscopy, found that as 75 percent of people regularly using NSAIDs develop low-grade inflammation in their small bowels. NSAIDs can also lead to development of fatty liver disease. This happens because your gut lining becomes more permeable, more toxins and bacteria from the outside world enters your liver and leads to inflammation.

A 2011 study titled Haemoglobin decreases in NSAID users over time: an analysis of two large outcome trials, states that as many as 6% of people taking NSAIDs regularly have found their blood count dropping within a few months of starting the medicines, this suggests that this is due to the small, slow amount of bleeding in the gut overtime.

According to the Indian Council of Medical Research - National Cancer Registry Programme (ICMR-NCRP), India reports about 220,000 new cases every year, and the common treatment procedure for this disease is chemotherapy, which comes with profound fatigue, hair loss, nausea, compromised immunity, and nerve damage.

The University College London led the Optima trial, which studied over 4000 patients with the disease in different parts of the world, and a low score on the genomic test could be mediated with only hormone therapy.

The trial’s chief investigator and a professor of breast oncology at UCL, Professor Rob Stein, explains that the study used tumour biology to guide decisions instead of relying on traditional clinical procedures.

The research had 4,429 women participants above the age of 40 years with hormone-positive breast cancer. These patients were then divided into two groups based on the genomic test results by the researchers, and one group with a higher risk was given chemotherapy along with hormone therapy, while the others were only treated with hormone therapy.

What Is Breast Cancer?

Breast cancer refers to the uncontrolled growth of the cells that are found along the inner lining of breast tissue. This out-of-control growth of cells leads to the formation of tumours. The tumour can be “invasive”, meaning that it spreads to the nearby tissues outside the breast, or “in situ”, where the tumour does not spread outside the breast region.

Usually, the “in situ” type of tumour is non-cancerous and non-life-threatening. However, in the case of invasive tumours, the cancerous cell mass can spread to the lymph nodes and further metastasise, that is, spread to other body parts. About 80% times the breast cancer cases are invasive. Hence, upon noticing symptoms like lumps, changes in breast shape, or abnormal nipple discharge, you must promptly consult a doctor.

While both men and women can develop it, in 99% of cases of breast cancer, women are seen to be affected by it. Only 0.5 to 1% of men are affected due to this condition. Furthermore, the condition is mostly prevalent in women aged 50 or older.

After the advent of Ozempic-like drugs, the treatment of obesity has completely changed. Millions of people throughout the world use the medication either for obesity or diabetes. Although there were always concerns among medical professionals that the medication not only reduces fat but also lean muscle, which in turn leads to health loss, as muscle is very important to long-term health.

Now, a new study presented at the European Atherosclerosis Society (EAS) Congress 2026 claims that this vital minus point of the drug, causing lean fat loss, can be mended by pairing it with exercise. The study suggests that combining the drug with exercise can lead to better fat loss, while the muscle will also stay protected. Though the study was done on animals, further research on humans is required.

The researchers studied mice with obesity, insulin resistance, fatty liver disease, and atherosclerosis. The animals were divided into groups and given semaglutide. After 14 weeks, it was found that the drug alone reduced fat by 31 percent but also caused muscle loss, while when the medication was given with exercise, it caused fat loss by 45 percent, and lean mass loss was minimal.

How Does Ozempic Function?

The first thing to remember here is that Ozempic is a brand-name medicine that contains semaglutide as its active ingredient. Semglutide is the synthetic version of GLP-1, a natural hormone produced in the intestines that regulates blood sugar, appetite, and digestion. Now, every time you eat, your body produces various hormones, including GLP-1. These are called post-nutrition hormones and help you absorb the energy you just consumed.

GLP-1 travels to your pancreas, prompting it to produce insulin. It also travels to the hypothalamus in your brain, which gives you the feeling of being full or satiated. Ozempic imitates this hormone, thereby silencing the food chatter in the brain. Interestingly, for some people this food chatter is really quiet ( people with low appetite), and for others it is an outburst (people who generally binge eat). So with Ozempic, silencing this self-talk in the brain, people tend to lose their appetite and eventually weight.

However, it is important to note that losing weight includes not just fat but muscle as well. Losing too much muscle can lead to reduced strength and a shorter life span. Notably, records show that most people who start taking them stop them at 12 weeks; therefore, it is important for some but not for others.

Ice cream is a sweet and delicious dessert loved and enjoyed by millions every day, and summers without this soothing treat are unimaginable, but some get a sharp stabbing pain after they have it. This headache is brain freeze, and it can reveal a lot about your health condition.

Amaal Starling, a neurologist at the Mayo Clinic in Minnesota, in the US, says, "Ice cream headache is very, very common." She added, "It's harmless, it comes, and it goes."

What Is Brain Freeze?

Scientists refer to brain freeze or ice cream headache as a cold-stimulus headache. According to the researchers, the reason for this condition is "rapid cooling at the roof of the mouth, or even in the very back of the throat". This cooling causes the blood vessels to shrink quickly after they return to their normal state. Which is the source of pain?

Why Do Some People Get These Ice Cream Headaches?

The research indicates that brain freeze seems to run in families. Though it also gets affected by your non-ice cream headaches, as people with migraines tend to feel far worse pain in brain freeze than others.

What Are The Common Headaches?

Stress Headaches

Stress headaches, also known as tension headaches, usually feel like a tight band squeezing your head. They are commonly caused by long working hours, lack of sleep, dehydration, or anxiety. However, these headaches generally go away with simple fixes, like rest, water, and relaxation techniques like yoga or meditation.

Migraines

Migraines often cause throbbing pain on one side of the head, along with nausea, vomiting, or sensitivity to light and sound. Some people also experience visual disturbances known as ‘auras’, flashes of light or zigzag patterns, before the headache even begins. They can last for hours or even days and may seriously impact the quality of life. Unlike stress headaches, migraines often need specific medication and lifestyle management.

When Do Headaches Mean Something More Serious?

Not every headache is about stress or migraines. Sometimes, a headache is a warning siren for something far more dangerous. Headaches can also indicate conditions such as high blood pressure, brain infections, stroke, or tumours. The red flags to look out for include:

• Sudden, severe headache (often described as the ‘worst headache of your life’)
• Headaches with vomiting, vision loss, or confusion
• Headaches after a head injury
• Headaches that worsen over time
• Headaches linked with fever or neck stiffness