Many of us may have taken ibuprofen, sometimes two pills at once, especially when we are struggling with menstrual cramps. Well, as good these pills may be in treating the pain, they are not recommended for your health, especially if you are someone who consumes it on a daily basis or frequently. Gastroenterologist Trisha Pasricha, MD, writes in The Washington Post about why should you avoid taking nonsteroidal anti-inflammatory drugs, or NSAIDs, such as ibuprofen, naproxen and aspirin.

What happens when you consume pain killers?

She writes that NSAIDs are great in treating short term pain. They comprise of a group of drugs that inhibit the production of prostaglandins, which serve as a variety of purposes in the body. Some of which also includes contracting the uterus during menses and regulating blood flow in our vessels.

While one to two doses every now and then is okay, following a regular dosage routine, which could range from several times a month, or twice in an hour or so could lead to health risk. NSAIDs are well known to increase intestinal permeability. This means, these painkillers could damage the lining of your gut.

A 2018 review by Ingvar Bjarnason et. al., also writes about how NSAIDs can reduce the blood flow in the tiny vessels that feeds our guts. It can also disrupt the intestinal cells forming a barrier between the outside world and your insides.

What can be done?

While people with conditions like migraines, chronic back pain or bad period cramps can find NSAIDs to be helpful. It is always advisable to have a chat with your physicians to explore NSAID alternatives.

Pasricha suggests acetaminophen.

However, if someone is in dire need of NSAID, her tip is to take the pill right at the start of your symptoms. She says that the drug can do a far better job at stopping things at the source than chasing after all prostaglandins.

Why is it a concern?

NSAIDs are available as over the counter drug, which means people do not need a prescription for it and can make medical decision about them without the guidance of a physician.

A 2018 study published in the Official Journal of the International Society for Pharmacoepidemiology by David W Kaufman, et.al., found that 15% of adult ibuprofen users in the US have exceeded the maximum recommended daily dose. The study also mentions that more than a third of ibuprofen users were taking other NSAIDs, like aspirin and naproxen, while consuming ibuprofen at the same time. Out of these, 61% did not realise that they were using NSAIDs.

Pasricha talks about how it ruptures the gut wall, as she herself has rushed to the hospital in the middle of the night "far more times than" she can count "to perform an emergency endoscopy on someone who was bleeding profusely from an ulcer caused by NSAID".

Another 2009 study published in the American Journal of Gastroenterology states that as many as 1 in 4 chronic NSAID users will get an ulcer and about 4% will bleed or rupture through the gut wall.

An older study from 2005 titled A quantitative analysis of NSAID-induced small bowel pathology by capsule enteroscopy, found that as 75 percent of people regularly using NSAIDs develop low-grade inflammation in their small bowels. NSAIDs can also lead to development of fatty liver disease. This happens because your gut lining becomes more permeable, more toxins and bacteria from the outside world enters your liver and leads to inflammation.

A 2011 study titled Haemoglobin decreases in NSAID users over time: an analysis of two large outcome trials, states that as many as 6% of people taking NSAIDs regularly have found their blood count dropping within a few months of starting the medicines, this suggests that this is due to the small, slow amount of bleeding in the gut overtime.

Think being in great shape and having a “normal” BMI gives men a good shot at fertility? Think again.

While fertility is usually seen as a women's issue, it's increasingly becoming a men's problem too. Sperm counts worldwide have dropped by more than half since 1973, and the decline has been speeding up in recent years. Now, a new study in Denmark just found something that should worry a lot of men.

Researchers looked at over a thousand young men and measured their actual body fat, not just their BMI. What they found was surprising. Men with a "normal" BMI but slightly higher body fat had noticeably lower sperm counts than leaner men in the same weight range.

The Numbers Don't Lie

Men with 20 to 24 percent body fat had sperm counts that were 23 percent lower than the leanest group. This gap showed up even among men who were considered to be of normal weight.

In other words, you could look completely fine, weigh the "right" amount for your height, and still be carrying extra fat that's actually messing with your hormones.

That's because body fat doesn't just sit there. It changes your hormone levels. The study, published in the journal Human Reproduction, found higher body fat was linked to lower testosterone, along with shifts in a few other hormones tied to reproduction.

“Higher body fat percentage was associated with poor semen characteristics and impaired reproductive hormone levels but not with testicular volume,” said the team from Aarhus University, Denmark.

The researchers noted that a higher percentage of adipose tissue might adversely affect semen production and hormonal balance.

Why Muscle Might Matter More Than Weight

It may not really be about losing weight at all. Other studies focus on muscle weight. Muscles may not be just something that makes you look good; they actually work like a hormone-producing organ in your body.

A 2025 study published in Frontiers in Endocrinology examined 823 semen analyses and concluded that assessing fat distribution, rather than obesity alone, could provide additional information about male reproductive health.

So for men thinking about having kids someday, hitting the gym and building muscle might do more for fertility than just watching the number on the scale go down.

What About Weight-Loss Drugs?

Even as many people now are on GLP-1 drugs like Ozempic and Wegovy for weight loss, the question is: do these drugs help or hurt fertility? The early research is actually reassuring.

A review presented at recent ENDO 2026 examined five randomized clinical trials and found no bad effects on hormones, sex drive, or sperm quality in men taking these drugs. However, doctors are worried about men who lose weight too fast and lose muscle along with the fat.

Other Factors That Can Affect Sperm Health

Body composition is only one factor linked to male reproductive health. Lifestyle factors such as smoking, heavy alcohol use, cannabis use, obesity and anabolic steroid use have also been associated with poorer sperm health.

Heat exposure may also affect sperm production. Regular use of saunas and hot tubs has been studied as a potential risk factor, while prolonged heat exposure from devices such as laptops placed directly on the lap has also raised concerns.

Disney star Debby Ryan has opened up about living with a “life-altering” brain injury that left her with “hellish” migraines.

Appearing on a web series, the 33-year-old Ryan said she has also suffered five concussions and revealed the “fringe science treatment” that helped her recover.

“The brain injuries make things significantly worse,” the Disney Channel alum said.

“I had a pretty crazy life-altering brain injury a few years ago, and I was out of commission for, like, six months. And I went to this neurological rehab,” Ryan shared. “[I] went and did this fringe science treatment that was, like, really sci-fi and crazy. … That kind of got me back online, but there were some things that just did not come back.”

According to Ryan, her first four concussions stemmed from blunt-force injuries, while her most recent concussion was caused by “sustained shaking over, like, a minute of time.”

How The Injury Changed Her Life

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Ryan said her life changed significantly after the injury. “There’s sort of pre-incident Debby and post-incident Debby,” she said.

She said that because of her migraines and brain injuries, she sometimes thinks better with her eyes closed, as the world can feel too bright and loud.

“Quite often the world is really loud. It’s really too bright, it’s too — there’s a lot going on,” she explained. “The visual data that I’m taking in can be so distracting.”

Ryan said she feels “very fortunate” that her “amazing” support system helped her deal with the aftermath of her latest concussion.

“[They] reminded me who I am and was and also held a lot of space for that to change — potentially permanently — and love me through that,” she said.

Ryan acknowledged that it must also have been difficult for her loved ones to process the changes.

How Does A Traumatic Brain Injury Affect You?

Cleveland Clinic explains that a traumatic brain injury (TBI) occurs when a sudden external force injures the brain. TBIs can range from mild to severe and may affect thinking, movement, memory, behavior and emotions.

Symptoms can include headaches, confusion, memory problems and mood or behavioral changes. Some people can also experience longer-term problems that affect their daily lives.

Types Of Traumatic Brain Injuries

There are two broad types of TBI:

• Penetrating TBI: This occurs when an object pierces the skull and enters the brain tissue, damaging part of the brain. It may also be called an open TBI.
• Blunt or closed TBI: This occurs when a forceful impact causes the brain to bounce or twist inside the skull.

According to the American Headache Society, post-traumatic headache is one of the most debilitating symptoms following a concussion.

Post-traumatic headache typically develops within seven days of a concussion or regaining consciousness after the injury. It can present in different ways but often resembles migraine in its symptoms and duration.

In some cases, these headaches can become persistent or chronic.

For years, doctors believed that menopause was the big trigger for heart-related changes in women. Turns out, that might not be the full story.

A new study, published in the journal Hypertension, found that something called pulse pressure starts rising in women as early as their late 30s. That's way earlier than the time most women hit menopause.

What Is Pulse Pressure?

Pulse pressure is just the gap between the two numbers you see in a blood pressure reading. The top one and the bottom one. As we age, this gap tends to widen. And when it widens too much, it's usually a sign that the aorta, the body's biggest blood vessel, is getting stiffer.

A stiffer aorta means your heart has to work harder to pump blood around your body. Over time, that extra strain adds up.

What Did The Study Find

Researchers looked at data from more than 9,500 people, over 6,500 women and around 3,000 men, all part of the Framingham Heart Study. This is one of the longest-running heart health studies in the world, and the participants were tracked across three health checkups over 14 years.

What they found was interesting. Pulse pressure hits its lowest point and then starts climbing about ten years earlier in women than in men. For women, this shift happens in the late 30s. For men, it's usually the late 40s. And by the time women reach around 60, their pulse pressure is consistently higher than men's.

This pattern showed up even when a woman went through menopause. Early, late, right on time, didn't matter. The rise in pulse pressure followed the same timeline regardless.

Gary F Mitchell, one of the researchers on the Framingham Heart Study, said the team was genuinely caught off guard by this. Menopause timing, it seems, wasn't the main thing driving the change; something else was clearly at play too.

"To our huge surprise, our results suggest that factors other than the timing of the final menstrual period were likely involved in the accelerated increase in pulse pressure in women after midlife," he noted.

Why This Actually Matters

Elevated pulse pressure isn't just a random number on a report. It's linked to a higher risk of heart disease, dementia, and even kidney disease. It can also make managing high blood pressure trickier, since some medications don't work as well once arteries get stiffer.

The bigger takeaway from this study is pretty simple. Women's heart health might need attention way earlier than we've been taught to think. Instead of waiting until menopause to start paying attention to cardiovascular health, doctors might need to start the conversation years earlier, around the late 30s.

So, if you're a woman in your 30s reading this, this isn't meant to scare you. It's just a reminder that heart health isn't something to put off until your 40s or 50s. A basic check on your pulse pressure now might tell you more than you'd expect.