Many of us may have taken ibuprofen, sometimes two pills at once, especially when we are struggling with menstrual cramps. Well, as good these pills may be in treating the pain, they are not recommended for your health, especially if you are someone who consumes it on a daily basis or frequently. Gastroenterologist Trisha Pasricha, MD, writes in The Washington Post about why should you avoid taking nonsteroidal anti-inflammatory drugs, or NSAIDs, such as ibuprofen, naproxen and aspirin.

What happens when you consume pain killers?

She writes that NSAIDs are great in treating short term pain. They comprise of a group of drugs that inhibit the production of prostaglandins, which serve as a variety of purposes in the body. Some of which also includes contracting the uterus during menses and regulating blood flow in our vessels.

While one to two doses every now and then is okay, following a regular dosage routine, which could range from several times a month, or twice in an hour or so could lead to health risk. NSAIDs are well known to increase intestinal permeability. This means, these painkillers could damage the lining of your gut.

A 2018 review by Ingvar Bjarnason et. al., also writes about how NSAIDs can reduce the blood flow in the tiny vessels that feeds our guts. It can also disrupt the intestinal cells forming a barrier between the outside world and your insides.

What can be done?

While people with conditions like migraines, chronic back pain or bad period cramps can find NSAIDs to be helpful. It is always advisable to have a chat with your physicians to explore NSAID alternatives.

Pasricha suggests acetaminophen.

However, if someone is in dire need of NSAID, her tip is to take the pill right at the start of your symptoms. She says that the drug can do a far better job at stopping things at the source than chasing after all prostaglandins.

Why is it a concern?

NSAIDs are available as over the counter drug, which means people do not need a prescription for it and can make medical decision about them without the guidance of a physician.

A 2018 study published in the Official Journal of the International Society for Pharmacoepidemiology by David W Kaufman, et.al., found that 15% of adult ibuprofen users in the US have exceeded the maximum recommended daily dose. The study also mentions that more than a third of ibuprofen users were taking other NSAIDs, like aspirin and naproxen, while consuming ibuprofen at the same time. Out of these, 61% did not realise that they were using NSAIDs.

Pasricha talks about how it ruptures the gut wall, as she herself has rushed to the hospital in the middle of the night "far more times than" she can count "to perform an emergency endoscopy on someone who was bleeding profusely from an ulcer caused by NSAID".

Another 2009 study published in the American Journal of Gastroenterology states that as many as 1 in 4 chronic NSAID users will get an ulcer and about 4% will bleed or rupture through the gut wall.

An older study from 2005 titled A quantitative analysis of NSAID-induced small bowel pathology by capsule enteroscopy, found that as 75 percent of people regularly using NSAIDs develop low-grade inflammation in their small bowels. NSAIDs can also lead to development of fatty liver disease. This happens because your gut lining becomes more permeable, more toxins and bacteria from the outside world enters your liver and leads to inflammation.

A 2011 study titled Haemoglobin decreases in NSAID users over time: an analysis of two large outcome trials, states that as many as 6% of people taking NSAIDs regularly have found their blood count dropping within a few months of starting the medicines, this suggests that this is due to the small, slow amount of bleeding in the gut overtime.

Bajau Sea Nomads have evolved beyond human limits. But how is that even possible? Remember Charles Darwin's theory of natural selection? The survival of the fittest? This is what kept the Bajau Sea Noamds going, and evolving.

The Bajau people are sea nomads who survive by collecting shellfish from the sea floor. They come from South-East Asia, and study shows that they have developed bigger spleen for diving. They are known as 'Sea Gypsies' and are known to hold their breath for over five minutes, whereas highly trained professionals can hardly hold their breath for three to four minutes. Bajau divers spend hours underwater for fishing. They are also the world's only community of self-sufficient sea nomads, reported The Guardian.

How The Bajau Sea Nomads Evolved: What Does The Study Say?

A study published in the academic journal Cell notes that the effect of their underwater lifestyle reflected on their biology. Their spleens were larger than those of other people from the region.

How The Bajau Sea Nomads Evolved: How Does A Spleen Work?

Tucked just beside the stomach, the spleen is roughly the size of a fist and usually flies under the radar. Its everyday job is to filter old red blood cells from the blood. But under the right conditions, it can also act like a built-in oxygen reserve.

This hidden ability is especially important for the Bajau people, often called “sea nomads,” who live across parts of the southern Philippines, Indonesia and Malaysia. Numbering roughly a million, the Bajau have relied almost entirely on the ocean for generations.

“For possibly thousands of years, they have been living on houseboats, travelling from place to place in the waters of South-East Asia and visiting land only occasionally,” said Melissa Ilardo from the University of Copenhagen, speaking to the BBC’s Inside Science. “Everything they need, they get from the sea.”

Read: A Genetic Disorder Caused This Indonesian Tribe To Have Sparkling Blue Eyes

How The Bajau Sea Nomads Have Evolved?

The Bajau are known for their extraordinary free-diving abilities. When diving in the traditional way, they spend up to eight hours a day at sea, with around 60 percent of that time underwater. Individual dives can last anywhere from 30 seconds to several minutes, often reaching depths of more than 70 metres.

What makes this even more remarkable is the equipment. Many Bajau divers use little more than a wooden mask or simple goggles and a weight belt. No oxygen tanks, no wetsuits, no modern diving aids.

This lifestyle prompted researchers to ask whether the Bajau body has adapted over time to support such extreme breath-hold diving.

According to Dr Ilardo, the spleen was an obvious place to look. Humans, like many marine mammals, have a natural “dive response” that kicks in when we hold our breath and submerge ourselves in water, especially cold water.

“When this response is triggered, your heart rate slows down,” she explained. “Blood vessels in your arms and legs constrict to preserve oxygen-rich blood for vital organs like the brain and heart.”

The final part of this response involves the spleen.

How The Bajau Sea Nomads Evolved: An enlarged Spleen Boosts Oxygen

The spleen acts as a reservoir for oxygenated red blood cells. When it contracts during a dive, it releases these cells into the bloodstream, giving the body a temporary oxygen boost.

“It’s like a biological scuba tank,” Dr Ilardo said.

For people like the Bajau, who dive repeatedly every day, this spleen contraction can make a crucial difference, helping them stay underwater longer and recover faster between dives.

In short, what seems like an ordinary organ plays an extraordinary role, revealing how the human body can adapt in remarkable ways to extreme environments.

One child in India dies every nine minutes from an infection caused by antibiotic-resistant bacteria, as it becomes one of the top 10 global public health threats, experts warn.

Dr HB Veena Kumari of the Department of Neuromicrobiology, National Institute of Mental Health and Neurosciences, claims: "The Covid-19 pandemic has significantly contributed to rising antimicrobial resistance. The World Health Organisation projects that 10 million deaths will occur annually by 2025."

According to the National Foundation for Infectious Diseases, antibiotic resistance occurs when bacteria in the body learns to withstand and remain unaffected by the medicines (antibiotics) meant to kill them.

In such cases, doctors have to switch to different antibiotics, but these backup medicines might not work as well or might cause more side effects. Additionally, infections may also worsen over time as bacteria can become resistant to all available drugs.

Alarmingly is that these tough, drug-resistant bacteria can spread from one person to another, both in hospitals and at home.

According to Dr TS Balganesh, Gangagen Biotechnologies, nearly 36 percent of haemodialysis patients die from fatal infections, which is second only to cardiovascular diseases as a cause of death.

He tells Deccan Herald: "The risk for infective endocarditis in haemodialysis patients is approximately 18 times higher than in the general population and up to 58 percent of these episodes are caused by a bacteria named 'S aureus', with an in-hospital mortality of more than 50 percent."

What Does WHO Say?

One out of every six serious infections confirmed in labs worldwide last year could not be killed by the antibiotics meant to treat them.

Between 2018 and 2023, the problem of antibiotics failing (called resistance) got much worse. For many common types of germs, resistance went up by 5% to 15% every year. The growing inability of these essential medicines to work is a huge threat to people everywhere.

Which Antibiotics Are People Becoming Resistant To?

The WHO's latest report is the most detailed look yet at this issue. It reports on how much resistance exists across 22 different antibiotics, which include common drugs used to treat everyday illnesses. The report focused on eight common types of bacteria that cause things like:

• Urinary tract infections (UTIs)
• Stomach and intestinal infections
• Dangerous blood infections
• Gonorrhoea

Additionally, Dr Obaidur Rahman of Dr Ram Manohar Lohia Hospital has also warned that the country’s casual use of Azithromycin, sold under brand names such as Zithromax, Azee and Zmax, has worsened its effectiveness and pushed India closer to a major public health challenge.

A drug often prescribed for sore throats and upper respiratory tract infections, Dr Rahman noted that Azithromycin was once effective against Mycoplasma Pneumonia, a bacterium responsible for pneumonia in adults and children.

READ MORE: India’s New Antibiotic in 30 Years Offers Hope Against Antibacterial-Resistant Infections

However, this is no longer the case as India now shows an alarming 80 to 90 percent resistance to the drug when treating infections caused by this bacterium. A medicine that once addressed a wide range of respiratory problems is no longer reliable for many patients.

The surgeon has since urged people to avoid taking antibiotics without proper medical advice. Most seasonal respiratory infections resolve on their own, and unnecessary drugs only add to the resistance problem.

Supreme Court on Friday declared the right to menstrual health as part of the right to life under Article 21 of the Constitution. The court issued a slew of directions to ensure that every school provides biodegradable sanitary napkins free of cost to adolescent girls. The guidelines also ensured that schools must be equipped with functional and hygienic gender-segregated toilets. The Court directed the pan-India implementation of the Union's national policy, 'Menstrual Hygiene Policy for School-going Girls' in schools for adolescent girl children from Classes 6-12.

Read: Menopause Clinics Explained: Latest Launch By Maharashtra And Kerala Government

Supreme Court Declares Menstrual Hygiene As Part Of Right To Life: Here Are the Directions

A bench comprising Justice JB Pardiwala and Justice R Mahadevan passed the following directions:

• All States/UT must ensure that every school, whether government-run or privately managed, in both urban and rural areas, is provided with functional gender segregated toilets with usable water connectivity.
• All existing or newly constructed toilets in schools shall be designed, constructed and maintained to ensure privacy and accessibility, including by catering to needs of children with disabilities.
• All school toilets must be equipped with functional washing facilities and soap and water available at all times.
• All states/UTs must ensure that every school, whether government-run or privately managed, in both urban and rural areas, provide oxo-biodegradable sanitary napkins manufactured in compliance with the ASTM D-6954 standards free of cost. Such sanitary napkins must be made readily accessible to girl students, preferably within toilet premises through sanitary napkin vending machines or, where not visible, at a designated place.
• All States/UTs must ensure that every school, whether government-run or privately managed, in both urban and rural areas establish menstrual hygiene management corners. It must be equipped with spare innerwears, uniforms, disposable pads and other necessary materials to address menstrual urgency.

The court also issued directions for the disposal of sanitary waste. Justice Pardiwala said, "This pronouncement is not just for stakeholders of the legal system. It is also meant for classrooms where girls hesitate to ask for help. It is for teachers who want to help but are restrained due to a lack of resources. And it is for parents who may not realise the impact of their silence and for society to establish its progress as a measure in how we protect the most vulnerable. We wish to communicate to every girlchild who may have become a victim of absenteeism because her body was perceived as a burden when the fault is not hers."

Read: Menstrual Cups To Replace Sanitary Napkins In Karnataka Government Schools

Why Is This Judgment So Important?

In India, menstruation is still seen as taboo. In fact, there is a lot of shame around it. Menstrual shame is the deeply internalized stigma, embarrassment, and negative perception surrounding menstruation, which causes individuals to feel unclean, or "less than" for a natural biological process. This judgment thus is an effort to do away with the shame rooted in cultural, social, and religious taboos, which is often the reason why many girls drop out, or due to lack of awareness, develop health adversities.