Many of us may have taken ibuprofen, sometimes two pills at once, especially when we are struggling with menstrual cramps. Well, as good these pills may be in treating the pain, they are not recommended for your health, especially if you are someone who consumes it on a daily basis or frequently. Gastroenterologist Trisha Pasricha, MD, writes in The Washington Post about why should you avoid taking nonsteroidal anti-inflammatory drugs, or NSAIDs, such as ibuprofen, naproxen and aspirin.

What happens when you consume pain killers?

She writes that NSAIDs are great in treating short term pain. They comprise of a group of drugs that inhibit the production of prostaglandins, which serve as a variety of purposes in the body. Some of which also includes contracting the uterus during menses and regulating blood flow in our vessels.

While one to two doses every now and then is okay, following a regular dosage routine, which could range from several times a month, or twice in an hour or so could lead to health risk. NSAIDs are well known to increase intestinal permeability. This means, these painkillers could damage the lining of your gut.

A 2018 review by Ingvar Bjarnason et. al., also writes about how NSAIDs can reduce the blood flow in the tiny vessels that feeds our guts. It can also disrupt the intestinal cells forming a barrier between the outside world and your insides.

What can be done?

While people with conditions like migraines, chronic back pain or bad period cramps can find NSAIDs to be helpful. It is always advisable to have a chat with your physicians to explore NSAID alternatives.

Pasricha suggests acetaminophen.

However, if someone is in dire need of NSAID, her tip is to take the pill right at the start of your symptoms. She says that the drug can do a far better job at stopping things at the source than chasing after all prostaglandins.

Why is it a concern?

NSAIDs are available as over the counter drug, which means people do not need a prescription for it and can make medical decision about them without the guidance of a physician.

A 2018 study published in the Official Journal of the International Society for Pharmacoepidemiology by David W Kaufman, et.al., found that 15% of adult ibuprofen users in the US have exceeded the maximum recommended daily dose. The study also mentions that more than a third of ibuprofen users were taking other NSAIDs, like aspirin and naproxen, while consuming ibuprofen at the same time. Out of these, 61% did not realise that they were using NSAIDs.

Pasricha talks about how it ruptures the gut wall, as she herself has rushed to the hospital in the middle of the night "far more times than" she can count "to perform an emergency endoscopy on someone who was bleeding profusely from an ulcer caused by NSAID".

Another 2009 study published in the American Journal of Gastroenterology states that as many as 1 in 4 chronic NSAID users will get an ulcer and about 4% will bleed or rupture through the gut wall.

An older study from 2005 titled A quantitative analysis of NSAID-induced small bowel pathology by capsule enteroscopy, found that as 75 percent of people regularly using NSAIDs develop low-grade inflammation in their small bowels. NSAIDs can also lead to development of fatty liver disease. This happens because your gut lining becomes more permeable, more toxins and bacteria from the outside world enters your liver and leads to inflammation.

A 2011 study titled Haemoglobin decreases in NSAID users over time: an analysis of two large outcome trials, states that as many as 6% of people taking NSAIDs regularly have found their blood count dropping within a few months of starting the medicines, this suggests that this is due to the small, slow amount of bleeding in the gut overtime.

Headaches are one of the most common health complaints and are often caused by stress, lack of sleep, dehydration, excessive screen time, skipped meals, or other lifestyle factors. While most headaches are benign, experts said that frequent or unusual headaches should not be ignored, as they may signal an underlying medical condition that requires evaluation.

The experts told HealthandMe that paying attention to changes in headache frequency, pattern, and associated symptoms can help identify when medical attention is necessary.

Increasing Frequency Is a Warning Sign

According to Dr. Rajneesh Kummar, Vice Chairman & Unit Head, Neurology, Max Super Speciality Hospital, Dwarka, one of the most common concerns is increasing frequency.

“If someone who previously experienced occasional headaches starts getting them several times a week or finds that painkillers are needed more often than before, it is worth getting evaluated,” he told HealthandMe.

“People should seek medical attention if they have headaches more than 10 to 15 days a month, if the headaches are getting worse, or if they are beginning to interfere with work, daily activities, or quality of life,” added Dr. Praveen Gupta, Chairman, MAIINS, Marengo Asia Hospitals, Gurugram. He also noted that medication-overuse headaches can result from taking painkillers regularly, leading to a cycle of recurrent pain.

Also read: Shingles Vaccine May Help Fight Dementia, Suggest Studies

Watch For Changes In Headache Pattern

A change in the pattern of headaches should not be ignored. Dr. Kummar said a headache that feels different from what a person has experienced in the past, particularly after the age of 50, deserves medical attention. Headaches that wake a person from sleep, are worse in the early morning, or are associated with vomiting should also be assessed further.

Dr. Gupta advised prompt medical evaluation for people over the age of 50 who develop a new type of headache. He also recommends seeing a doctor if a person has a history of cancer, a weakened immune system, or develops a headache after a head injury.

Symptoms That Need Immediate Medical Attention

The neurologists highlight several "red flag" symptoms that require urgent medical assessment. They advised immediate consultation if a headache is accompanied by

• weakness on one side of the body,
• difficulty speaking,
• double vision,
• confusion, seizures,
• loss of consciousness,
• Numbness
• balance problems

Read More:Sepsis: India Joins Global Trial To Screen Newborns For Deadly Drug-Resistant Infections

Not Every Headache Is a Brain Tumor

Dr. Kummar stated that many people worry that every headache is related to a brain tumor or another serious brain disorder. Fortunately, this is rarely the case.

However, persistent or unusual headaches should not be self-diagnosed, and timely consultation helps identify the cause and ensures appropriate treatment before the problem begins affecting quality of life, the expert said.

Early Diagnosis Key

Dr. Gupta told HealthandMe that early diagnosis can help manage common neurological disorders such as migraines, cluster headaches, and chronic tension-type headaches. A thorough history, neurological examination, and imaging studies, when appropriate, can help determine the cause.

The experts emphasize that if headaches are becoming more frequent, changing in patterns, or affecting daily life, it is time to consult a neurologist. Early diagnosis can provide relief, prevent complications, and improve overall quality of life.

Several recent studies suggest that older adults who receive the shingles vaccine may be less likely to develop dementia, a condition affecting more than 57 million people worldwide.

Shingles is a painful viral infection caused by the reactivation of the varicella-zoster virus (VZV), which can remain dormant after chickenpox and later trigger a blistering rash and severe nerve pain.

Shingrix Vaccine And Reduced Dementia Risk

A June 2026 study published in the Annals of Internal Medicine suggests that one in 17 dementia cases could potentially be prevented through shingles vaccination.

Researchers at Brown University found that older adults who received the recombinant shingles vaccine (Shingrix) after a stay in a skilled nursing facility had a 24% lower risk of being diagnosed with dementia over four years than those who were not vaccinated.

The study analyzed Medicare and health records from more than 500,000 adults aged 66 and older admitted to skilled nursing facilities. Researchers compared those who received at least one dose of Shingrix with those who remained unvaccinated.

“A lot of previous studies with similar results focused on an older vaccine,” said study author Kaley Hayes, an assistant professor at Brown University’s School of Public Health.

“This study looks at the newest vaccine only in an older, vulnerable adult population who were not up to date with shingles vaccination and are at a very clear clinical point in care: entering a skilled nursing facility.”

The findings add to growing evidence linking shingles vaccination with a lower risk of dementia.

Also read: How To Spot Leptospirosis, Dengue, Malaria During Monsoons? Early Symptoms Not To Neglect

How Does The Vaccine Protect The Brain?

Researchers believe the vaccine may help protect the brain by preventing shingles and the inflammation caused by the virus.

Shingles can cause a “war zone” of inflammation in the brain, said Dr. Jennifer Pauldurai, the medical director of the Inova Brain Health and Memory Disorders Program in Northern Virginia, NBC News reported.

It’s not that the shingles vaccine itself is a “magic pill,” Pauldurai said.

Rather, the vaccine guards against the disease, which is known to disrupt brain health.

Evidence from Wales, Australia, and Canada

The latest findings add to a growing body of international research.

A study involving more than 282,000 older adults in Wales, published in Nature in 2025, found shingles vaccination was associated with a 3.5% lower absolute risk of dementia over seven years.

Another study of more than 101,000 older adults in Australia, published in the Journal of the American Medical Association in 2025, found vaccine eligibility was associated with a 1.8% lower dementia risk over 7.4 years.

Similarly, a study involving more than 232,000 older adults in Canada, published in The Lancet Neurology in 2026, linked shingles vaccine eligibility to a 2% lower dementia risk over 5.5 years.

Read More: Sepsis: India Joins Global Trial To Screen Newborns For Deadly Drug-Resistant Infections

Shingles: Early Warning Signs

After a person recovers from chickenpox, the VZV virus remains dormant in nerve cells and can become active again years or even decades later, particularly when the immune system weakens.

Older adults and people with weakened immune systems are at the highest risk of developing shingles.

According to the NHS, shingles often starts with:

• Burning, tingling, itching, or pain on one side of the body
• Headache or feeling generally unwell
• A blistering rash that develops within a few days, most commonly on the chest or abdomen

When To See A Doctor

Seek prompt medical attention if:

• The rash appears on or near the eye
• The pain is severe or rapidly spreading
• You have a weakened immune system
• You are pregnant
• Symptoms are worsening quickly

From bone smashing to black market peptides, the modern push to “optimize” the male body increasingly runs through human endocrinology, often without a doctor anywhere in the loop.

A Trend That Outgrew Its Origins

Looksmaxxing began on incel forums that blamed romantic failure on fixed facial geometry. That ideology has since spread to TikTok and Instagram, stripped of some of its uglier language but keeping its core premise: a man’s body can and should be engineered, whatever the cost. What started as a fringe belief system now functions as mainstream influencer content with millions of followers.

Clinicians split the practice into softmaxing (sleep, skincare, fitness, mostly harmless) and hardmaxxing, which branches into two wings: mechanical (bone smashing, jaw implants, leg lengthening) and pharmaceutical (unsupervised testosterone, anabolic steroids, SARMs, and peptides marketed as growth hormone substitutes). The pharmaceutical wing is growing fastest, and it sits squarely in endocrinology’s territory.

What These Drugs Actually Do

The body regulates testosterone through a feedback loop running from the hypothalamus to the pituitary to the testes. Flood that system with outside testosterone or anabolic steroids, and it shuts down its own production, taking fertility down with it. SARMs were built to act on muscle and bone while sparing the prostate, but none are approved for human use, and the versions sold online are unregulated and inconsistently dosed. Peptides like ibutamoren (MK-677) stimulate the body’s own growth hormone release. The mechanism sounds gentler, but few have completed real clinical trials for the uses they are marketed for.

The Documented Harms

Anabolic steroids:

● Testicular atrophy and infertility from HPG axis suppression

● Gynecomastia, from testosterone converting to estrogen

● Hepatotoxicity, especially with oral forms

● Psychiatric effects at high doses, including mood instability

SARMs:

● Liver injury, including cholestatic jaundice in black market cases

● Dose-dependent suppression of natural testosterone production

● Elevated liver enzymes, reduced HDL cholesterol

Across the board:

● Elevated hematocrit, raising clotting risk if unmonitored

● Adrenal suppression and disruption of corticosteroid and DHEAS production: exogenous androgens interfere with the hypothalamic-pituitary-adrenal axis, blunting the adrenal gland’s output of cortisol and dehydroepiandrosterone sulphate (DHEAS). The result is impaired stress response, fatigue, and hormonal dysregulation that persists well after the substance is stopped.

● Elevated blood pressure and increased cardiac sympathetic drive: anabolic agents raise systolic pressure and heighten sympathetic nervous system activity in the heart, accelerating resting heart rate and increasing myocardial oxygen demand. Over time, this contributes to left ventricular hypertrophy and raises the risk of arrhythmia.

● Unreliable contents: labels rarely match what is actually in the product, and contamination or substitution is common enough that toxicology reports periodically turn up drugs users never intended to take.

The Mechanical Risks

Bone smashing has no basis in orthopedic science. Bone remodels under sustained load, not blunt trauma, which produces fractures, hematomas, and sometimes permanent damage. Cosmetic jaw implants and leg lengthening are legitimate procedures in the right clinical context, but carry the same surgical risks, infection, nerve damage, long recovery, without the medical justification that normally accompanies them.

The pharmaceutical track carries its own structural toll: supraphysiological androgen levels accelerate calcification in tendons and menisci, reducing their elasticity and load-bearing capacity. Meniscal and tendon calcinosis increases the risk of tears and joint instability, often in the absence of any acute injury. Athletes who stop using these compounds may find the damage is already done.

A related danger runs alongside both tracks. Some men adopt extreme dieting, dehydration, or fasting protocols purely to sharpen jaw and cheekbone definition before photos. The behavior carries the same physical risks as any restrictive eating disorder, yet it rarely gets recognized or treated as one, since it is framed online as discipline rather than disorder.

Why Now

Gallup polling found that roughly a quarter of young American men report frequent loneliness, a notably higher rate than young women. Online communities built around appearance fill that gap with something that looks like belonging, even though the content itself runs on comparison and self-criticism.

TikTok’s own data illustrate how fast the trend has moved: searches for bone smashing and related terms ran in the hundreds of thousands per day in early 2026 and climbed into the millions within a month, before the platform restricted the content. Marketing has kept pace too: one UK survey found nearly a third of 16 to 25-year-olds see SARM ads on social media weekly.

What Legitimate Treatment Looks Like

TRT for confirmed hypogonadism, diagnosed through repeat morning bloodwork and monitored over time, is genuinely effective medicine. That is a different undertaking entirely from a eugonadal man sourcing hormones or peptides online to chase a feeling, with no diagnosis and no monitoring. The same distinction applies to surgery: a qualified surgeon’s evaluation is not the same as a procedure booked off a forum recommendation.

The Bottom Line

None of this is an argument against fitness or grooming, and most softmaxxing is harmless. The danger lies in a narrower set of behaviors: fracturing healthy bone, importing unregulated hormones, chasing a standard that keeps moving regardless of what is achieved.

Endocrinologists studying this are not against masculinity or ambition about one’s appearance. They are arguing that hormonal systems deserve the same evidence-based caution as any other organ system, and that distinction matters more now that these behaviors are still treated as cultural curiosities rather than the clinical concerns they actually are. A blood test and a doctor’s judgment remain better tools than a forum thread and a vial of unknown origin.