The United Kingdom recently banned the sale of cigarettes to people under 18 years. One of the many reasons that it was banned was that it caused lung cancer. Alcohol also causes cancer, and we’ve known that for at least 37 years, since the World Health Organisation (WHO) first published findings in 1987. Yet sales remain strong.

What Exactly Is Alcohol? And Why Does It Sell So Much?

Alcohol is a chemical compound that typically refers to ethanol, the type found in alcoholic beverages like beer, wine, and spirits. It is produced through the fermentation of sugars by yeast, and when consumed, it acts as a depressant on the central nervous system. This intoxicating effect is the reason it sells so much.

What Does Alcohol Do To Your Brain?

Primarily, alcohol interferes with the brain's communication pathways. According to the National Institutes of Health (NIH), alcohol can also alter how the brain looks and functions. It disrupts the areas of the brain responsible for balance, memory, speech, and judgment, increasing the likelihood of injuries and other negative outcomes. Long-term alcohol consumption can permanently change neural pathways, leading to lasting cognitive and emotional effects.

Moreover, it is a proven fact that alcohol can worsen mood swings. Recent research shows that alcohol may exacerbate symptoms of bipolar disorder by destabilising mood, which impacts efficiency at work. Alcohol also affects conditions like depression and panic disorder, and can trigger impulsive behaviour. Additionally, alcohol has been shown to disrupt sleep patterns, making it harder to get restorative rest.

What Does Alcohol Do To Your Heart?

Alcohol, particularly heavy drinking, including heart conditions. Excessive alcohol intake can lead to high blood pressure, heart failure or stroke. Excessive drinking can also contribute to cardiomyopathy, a disorder that affects the heart muscle.

What’s more, alcohol can contribute to obesity and the long list of health problems that can go along with it. Alcohol is a source of excess calories and a cause of weight gain that can be harmful in the long term. The takeaway is what you probably already knew: If you choose to drink alcohol, stick to moderate levels of drinking, and don’t overdo it.

A baby boy in the United Kingdom was born twice—first in the womb and again at full term which was nothing short of an extraordinary medical feat that borders on the miraculous. Meet baby Rafferty Isaac, a symbol of survival, and his mother Lucy, whose determination and courage have moved the world.

For 32-year-old Lucy Isaac, a special needs teacher from Reading, her pregnancy journey took an unexpected turn during a routine ultrasound scan at 12 weeks. The scan revealed signs of ovarian cancer, a diagnosis that would terrify any expectant mother. Waiting to treat the cancer until after delivery was not an option, as the disease risked spreading rapidly. Yet performing conventional laparoscopic surgery during the second trimester was equally out of the question—her pregnancy had already advanced to the point where it complicated standard treatment approaches.

Time was running out. Lucy’s doctors at John Radcliffe Hospital in Oxford knew that urgent action was needed to save both mother and child. And so, they turned to an operation that had rarely been performed before—one that would test the limits of surgical precision and maternal strength.

What followed was a pioneering and high-risk five-hour surgery, led by consultant gynecological oncologist Dr. Hooman Soleymani Majd. The procedure involved temporarily removing Lucy’s womb—still carrying her unborn baby Rafferty—from her abdomen. This gave surgeons access to the cancerous tumors growing behind it. Wrapped in warm, sterile saline gauze to maintain body-like conditions, Lucy’s uterus remained connected to vital structures including the uterine artery, cervix, and umbilical cord, while two dedicated medics monitored Rafferty's heartbeat and temperature in real time.

For approximately two hours, Rafferty floated safely outside his mother’s body, held gently by doctors as his mother’s life hung in the balance. Her tumors, diagnosed as grade two, had already begun to invade surrounding tissues, complicating the delicate surgery even further. A surgical team of more than 15—consisting of surgeons, nurses, and anesthetists—worked in unison, navigating the tightrope between preserving life and preventing tragedy.

Despite the enormous risks, the surgery was a success. The tumors were removed, and the womb was carefully repositioned into Lucy’s body to allow the pregnancy to continue as naturally as possible.

Fast forward to January: after weeks of recovery and cautious monitoring, Lucy gave birth to a healthy baby boy, Rafferty Isaac, weighing 6 pounds 5 ounces. For Lucy and her husband Adam, who had undergone a kidney transplant just two years prior, the moment was deeply emotional.

“To finally hold Rafferty in our arms after everything we have been through was the most amazing moment,” said Adam, reflecting on the turbulent journey they had braved together.

Surgeon Dr. Majd, who had only performed the procedure a handful of times before, described the experience as one of the most emotional moments in his career. “It felt as if I had met him previously,” he said, referring to the rare encounter during surgery. Baby Rafferty’s safe arrival symbolized not just survival but a second chance at life.

What Is the Rare Surgery Doctors Performed?

The medical term for the procedure is extra-corporeal uterine surgery, an extremely rare and delicate operation that involves temporarily removing the uterus while preserving fetal life. Though rare, the surgery exemplifies the potential of maternal-fetal medicine when facing dual life-threatening conditions.

Throughout the procedure, maintaining the uterine temperature and blood supply was crucial to preventing fetal distress. The uterus was kept wrapped in warm sterile gauze, and medics ensured constant circulation through the uterine artery. Fetal heart monitoring continued throughout. The team used surgical planning strategies usually reserved for complex oncological operations, paired with advanced obstetric care.

This case also sheds light on how high-risk pregnancies can be managed innovatively through a multidisciplinary approach. It required not only gynecologic oncology but also obstetrics, neonatology, anesthesiology, and surgical nursing teams working seamlessly together.

Lucy considers herself incredibly lucky that her ovarian cancer was detected so early, even before symptoms appeared. Ovarian cancer often goes undetected until its later stages, making early diagnosis critical. According to statistics, approximately 7,000 women in the UK are diagnosed with ovarian cancer each year, and survival rates improve significantly with early intervention.

Baby Rafferty, now eleven weeks old, is thriving—a joyful reminder of how hope, medical innovation, and human courage can intersect to create what some might call a miracle. His story also serves as a beacon of possibility for expectant mothers facing complex diagnoses.

The latest annual report on cancer in the United States is a combination of good news and concern. While overall death rates from cancer continue to decline, an unexpected and troubling trend is emerging — more women are being diagnosed with cancer every year.

Published on April 21, 2025, in the journal Cancer, the 2024 Annual Report to the Nation on the Status of Cancer presents a complex image of progress and disparity. A collaborative effort of the National Cancer Institute (NCI), Centers for Disease Control and Prevention (CDC), American Cancer Society (ACS), and North American Association of Central Cancer Registries (NAACCR), the report provides a complete picture of U.S. cancer incidence and death trends between 2001 and 2022.

One of the brightest findings in the report is that cancer mortality rates have been falling steadily for men and women since 2001. The decline continued even in the early years of the COVID-19 pandemic.

The American Cancer Society credits this decline to a 32% reduction in cancer death rates between 1991 and 2019. This has meant an estimated 3.5 million deaths from cancer prevented, thanks to earlier diagnosis, changes in lifestyle, and medical advances.

Clerk of court records show this progress has included the decline of lung cancer death — one of the major factors in cancer-related deaths. The mortality rates among other smoking-associated cancers have significantly decreased as a direct result of declining smoking incidence over the years.

Better screening procedures have had a significant bearing on lowering death due to cancer. For instance:

Mortality from colorectal cancer has fallen by 52% in adults aged 50–75 years, largely as a result of regular screening.

Deaths from breast cancer have fallen by some 40% since the use of mammography became more common.

These results highlight the effectiveness of early diagnosis in enhancing survival and reducing disease burden.

Prevention Through Lifestyle Changes

As treatment advances are making front-page news, the report insists on the critical importance of prevention. Anti-smoking campaigns have dramatically reduced prevalence from more than 40% in the 1960s to only 14% nowadays, leading to important declines in tobacco-related cancers.

Public health initiatives urging healthier eating, more exercise, and weight control have also played a role in reducing risk. Remarkably, as many as 40% of cancers have been estimated to be preventable by such changes in lifestyle.

Impact of COVID-19 on Cancer Care

The report isn't afraid of the pandemic disruption to healthcare services. Cancer rates fell significantly in 2020, not as a result of genuine falls in disease but as a result of postponements in screening and diagnosis. By 2021, figures bounced back, suggesting that normal healthcare access resumed.

This volatility unearthed the compelling necessity for unwavering continuity of access to cancer care during even public health emergencies. The states exhibited uniform trends in the 2020 decline, apart from differing policy responses to COVID-19.

Why More Women Are Getting Diagnosed?

Even with the encouraging news on cancer mortality, concerning is the fact that cancer incidence in women has been increasing steadily. Between 2003 and 2021, the number of new cases in women ticked up slightly each year — except for a temporary decrease in 2020, when it happened during the pandemic. A number of explanations are probably to blame:

1. Obesity-Related Cancers Are on the Rise

The report identifies an increasing number of cancers associated with obesity, many of which disproportionately affect women. These include:

• Breast cancer in women
• Uterine (endometrial) cancer
• Pancreatic cancer
• Colon and rectal cancer
• Kidney and liver cancers

Rates of obesity have been consistently rising in the U.S., and women tend to experience distinctive metabolic and hormonal alterations (e.g., post-menopause) that can make them more susceptible to these cancers.

2. Enhanced Screening and Awareness

In part, the increase may be an artifact of better screening and female health awareness. More detection of early-stage cancer such as breast and cervical cancer — particularly in women who receive regular healthcare — is a healthy trend, albeit one that can temporarily boost incidence rates.

3. Environmental and Hormonal Factors

Endocrine-disrupting chemicals, hormone replacement therapy, and chronic exposure to estrogen (resulting from delayed childbearing or lower pregnancy rates) can cause elevated risk for specific cancers in women, such as breast and uterine cancer.

4. Racial and Ethnic Disparities in Cancer Diagnosis

The report points out that American Indian and Alaska Native women now have the highest cancer rate among all racial and ethnic female populations. This may be attributed to various factors — such as limited access to preventive care, socioeconomic challenges, environmental exposure, and genetic susceptibility.

Is There A Gender Disparities in Cancer Care?

The growing incidence of cancer among women underscores the necessity for gendered approaches to cancer prevention. While deaths are declining — a testament to progress — further action must be taken to:

• Combat the epidemic of obesity
• Provide access to early detection and treatment for all
• Target special hormonal and environmental risk factors in women

Healthcare systems need to respond to this changing environment with a comprehensive, integrated, and preventive strategy for cancer control that involves women from all walks of life.

The 2024 Annual Report on Cancer presents a reassuring vision of gradual reductions in cancer deaths due to decades of research, public health efforts, and medical progress. Yet the simultaneous increase in cancer incidence among women requires closer scrutiny.

Why your body’s real age might be older or younger than the number on your birthday cake. Aging is a natural part of life, but what if your body is aging faster than it should? While your birth date gives you a chronological age, your biological age tells a more nuanced, and often more accurate, story about how well or poorly your body is holding up. In recent years, scientists have emphasized the significance of biological age as a powerful indicator of health risks, longevity, and overall physiological decline.

Chronological age is simple it’s the number of years you’ve been alive. Biological age, on the other hand, measures how your body functions on a cellular and molecular level. It considers markers like DNA methylation, telomere length, and inflammation, offering a clearer picture of your physical health.

For example, someone may be 45 years old chronologically but have a biological age closer to 55 due to poor lifestyle choices, chronic stress, or disease. Conversely, a person in their 60s who leads a healthy life might have the biological age of someone in their 40s.

Emerging research confirms that biological age is a stronger predictor of mortality and disease than chronological age, especially in critically ill patients. This insight is shifting the healthcare paradigm toward personalized, preventative strategies that focus on biological aging.

Role of Biomarkers in Biological Aging

To determine biological age, researchers assess various biomarkers, each offering a snapshot of different aspects of aging.

Telomere Length: Telomeres are protective caps at the ends of chromosomes. They shorten each time a cell divides, and when they become critically short, cells either stop functioning or die. Accelerated telomere shortening is linked with premature aging and age-related diseases.

Epigenetic Clocks: These tools, including DNAmAge, Hannum, PhenoAge, and GrimAge, measure changes in DNA methylation—chemical modifications that influence gene expression. PhenoAge and GrimAge, in particular, closely correlate with telomere length and can predict disease onset and lifespan with remarkable accuracy.

Inflammation Markers: Chronic low-grade inflammation, also known as “inflammaging,” is a key driver of age-related disorders. Blood levels of C-reactive protein (CRP) and various cytokines can reveal how inflamed—and therefore how aged—the body really is.

These biomarkers collectively help gauge the true biological toll life has taken on the body, far beyond what a birth certificate can tell you.

Health Risks of Premature Biological Aging

Biological age has real-world health consequences. Individuals whose biological age outpaces their chronological age are at higher risk for chronic diseases, including cardiovascular conditions, cancer, and neurodegenerative disorders.

Heart Disease and Cancer: Aging naturally compromises the cardiovascular system. But accelerated aging, especially in the presence of risk factors like obesity, diabetes, or hypertension, hastens this decline. Likewise, age-related changes such as inflammation, mitochondrial dysfunction, and cellular senescence create fertile ground for cancer development.

Cancer Survivors and Cardiovascular Risks: Cancer therapies, particularly in older adults, may further accelerate biological aging. Studies show that survivors over age 65 face increased cardiovascular risks, often surpassing cancer as the leading cause of death in this group.

Signs to Watch For You Aging Faster Than You Should

While diagnostic tools can assess biological age in a clinical setting, your body often sends early warning signals of premature aging. If you’re noticing these signs, it may be time to reassess your health habits.

1. Sun-Damaged Skin

Excessive UV exposure breaks down collagen and elastin, leading to sagging skin, fine lines, and pigmentation issues. Skin that appears leathery, paper-thin, or mottled may signal underlying cellular damage.

2. Stiff Joints

Unexplained joint pain or reduced flexibility in your 30s or 40s can reflect early cartilage wear—an age-related phenomenon that may be sped up by sedentary habits or inflammation.

3. Early Hearing Loss

Hearing changes are expected with age, but if you're experiencing diminished hearing sensitivity before age 60, noise-induced damage from headphones, loud environments, or machinery could be aging your auditory system prematurely.

4. Accelerated Hair Loss

While graying and thinning are normal, sudden shedding—especially after stress—may be linked to hormone shifts or inflammatory processes that mimic aging.

5. Weak Immune Function

If you frequently catch infections or struggle to recover, your immune system might be aging faster than it should. Chronic stress and poor nutrition can accelerate immune aging, raising susceptibility to disease.

6. Cognitive Fog and Memory Lapses

Occasional forgetfulness is normal, but persistent memory problems or reduced focus in midlife may be signs of neurobiological aging driven by poor sleep, stress, or lack of mental stimulation.

7. Bruising Easily

Thinning skin and fragile capillaries increase bruising with age, but if it’s happening too frequently—or suddenly—it might reflect premature structural breakdown of connective tissues.

8. Irregular Menstrual Cycles

Hormonal shifts that occur in perimenopause usually start in the 40s. But if you’re seeing major menstrual changes in your 30s, early menopause or ovarian aging could be to blame.

Can You Reverse or Slow Down Biological Aging?

The good news: biological age is modifiable. Interventions that reduce oxidative stress, improve metabolic health, and lower inflammation can reverse certain signs of accelerated aging.

Nutrition: Diets high in fresh produce, lean protein, and healthy fats combat inflammation and support cellular health. Reducing sugar and refined carbohydrates may also protect your skin and brain.

Exercise: Regular physical activity boosts cardiovascular health, builds muscle mass, and slows telomere shortening.

Sleep and Stress Management: Prioritizing deep, restful sleep and adopting stress-relief techniques like mindfulness and therapy can positively impact your biological age.

Preventive Healthcare: Getting regular screenings and addressing metabolic conditions early on helps keep your biological age aligned with or younger than your chronological one.