We all enjoy a good slushie every now and then. While they do not add any great nutritional value to our meal, they are a delightful snack made with shredded ice and sugar. To make them more accessible to people who cannot or do not wish to have sugar, there are many sugar free options to pick from. However, a recent study has revealed that sugar-free slushies containing glycerol, which is a sugar alcohol used to maintain their icy texture, can cause severe health problems in young children. The study was published in the journal Archives of Disease in Childhood, it explains that having these sugar free slushies can lead to children having a condition called "glycerol intoxication syndrome". In this condition there is a rapid drop in blood sugar, reduced consciousness, and a buildup of acid in the blood.

Rapid Onset of Symptoms

Kids who drank slushies with glycerol got sick very quickly. Within an hour, they started showing serious symptoms. Their blood sugar would plummet, sometimes dangerously low. Many became confused or lost consciousness, and some even had seizures. Doctors studied 21 children who got sick from these drinks between 2018 and 2024. Most of these kids were very young, seven years old or younger. By the time they got to the hospital, many were in bad shape, either unconscious or barely awake. This quick reaction time makes it especially scary, as parents might not realize the slushy is the cause right away. It's important to recognize these signs fast.

Why is Glycerol Harmful?

According to WebMD Glycerol is a type of naturally occurring alcohol, and it's used in lots of food products. You might find it in protein bars, diet foods, and even sugar-free candies. In slushies, it plays a key role in keeping the drink icy. Usually, slushies use tons of sugar to stop them from freezing completely. But because people are trying to cut back on sugar, companies are using glycerol instead. This is especially true in places with "sugar taxes," where sugary drinks cost more. So, to make sugar-free versions, they add glycerol. This switch means more kids are being exposed to this ingredient, which can be harmful to them.

What Does Glycerol Damage Children's Health?

The study explains that little kids are more at risk from glycerol because their bodies are still growing and developing. Their tiny bodies and young metabolisms might not be able to handle glycerol as well as adults' bodies can. This means that even a small amount can cause a big problem. Also, the amount of glycerol in a slushy can vary, and it's hard to know exactly how much is safe. Factors like how fast they drink it, if they've eaten recently, or if they've been exercising can also make a difference. Even the standard size of a slushy drink can be too much for a small child. This makes it hard to give a safe dose.

Health authorities in the UK and Ireland have already started warning about glycerol in slushies. They suggest that kids under four shouldn't have them at all, and older kids should only have one at most. But doctors are worried that these warnings might not be enough. They point out that it's hard to know how much glycerol is actually in each drink, making it difficult to give safe advice. Parents are being told to be very careful and consider avoiding these drinks altogether for young children. In the US, glycerol is approved for use in food, but parents should still be aware of the potential risks. More research is needed to understand the full impact.

Oral cancer cases are on the rise because of tobacco chewing, smoking, alcohol consumption, poor oral hygiene, and delayed medical attention. Many people ignore small red or white patches, which are early warning signs of cancer and should never be overlooked. There is an average delay of six months in cancer diagnosis, which is the reason patients are diagnosed with stage 3 and 4 cancers.

Dr Prathamesh Pai, Senior Consultant Head and Neck Surgical Oncologist, Gleneagles Hospital, Parel, Mumbai, explained the difference between red and white patches in the mouth and what they may indicate about your health.

Red vs White Patches in the Mouth

White patches inside the mouth are called leukoplakia, while red patches are known as erythroplakia. Both can occur on the tongue, gums, inner cheeks, or floor of the mouth. Though both need equal attention, red patches are more dangerous, with a higher risk of being cancerous in comparison to white patches. Red patches in the mouth indicate severe abnormal cellular changes, which can develop into precancerous conditions or cancer. Around 60% to 80% of erythroplakias are diagnosed as early-stage cancer on biopsy.

What is erythroplakia?

Erythroplakia is a fiery red, well-defined patch in the mouth. These lesions are velvety in appearance. They often appear on the floor of the mouth or the retromolar trigone (the area behind the wisdom teeth). Red patches often go unreported, as they are mistaken for traumatic mouth ulcers caused by hard foods or dental irritation.

If a red patch does not heal within two to three weeks, it should raise concerns about cancer. Besides the duration, patches that bleed on touch, are painful while eating, are associated with a burning sensation, difficulty swallowing, loosening of teeth, or voice changes should be investigated. Tobacco users should be even more mindful. Ignoring persistent red or white patches can allow the disease to progress silently.

So, make sure to seek immediate help and consult a doctor. For anyone presenting with red or white patches, the doctor will carry out a physical oral examination and a biopsy, in which a small tissue sample is taken from the patch for evaluation. A CT scan and MRI may also be advised, depending on the location of the patch and other clinical features.

Why early detection of cancer matters

Remember, early detection of cancer is curable. Treatment is also less extensive, often involving minor intraoral surgery and preservation of speech and swallowing functions. As the cancer stage advances, surgery may require the removal of parts of the cheek, jaw, or tongue, as well as postoperative radiotherapy. This affects the face and neck and hampers important functions such as eating, speaking, and swallowing. This has major implications for quality of life. Treatment can also be a financial burden, especially for younger patients.

Take charge of your life. Lead a happy, healthy life. Avoid tobacco, alcohol, and other addictions. Visit your dentist regularly and maintain good oral hygiene. Prevention is better than cure. In the case of any non-healing ulcers in the mouth, swelling in the neck, altered speech or swallowing, or altered bowel habits for more than two weeks despite treatment, do visit a doctor. Remember, early detection of cancer is curable.

New Delhi's weather is fluctuating sharply, with Western Disturbances driving bouts of intense heat and sudden pre-monsoon showers. The city is currently hovering in the mid-30s°C but is also bracing for a return to scorching heat, with maximum temperatures forecast to climb into the low to mid-40s°C this week.

Such weather fluctuations can play a significant role in triggering migraine attacks, said Dr. Vivek Kumar, Principal Director - Neurology, Max Super Speciality Hospital, Patparganj.

Weather Factors That Can Trigger Migraines

Speaking to HealthandMe, Dr. Vivek noted that many components of weather are reported to affect migraine. These include:

• Barometric pressure
• Humidity
• Temperature
• Seasons

Dr. Kumar explained that a drop in atmospheric pressure, often seen before storms, can create a pressure imbalance between the environment and the sinuses or inner ear, stimulating nerves and leading to headaches.

"Rapid temperature changes, as well as exposure to extreme heat or cold, can also trigger migraine episodes," he said.

Similarly, both high humidity and very dry air have been associated with the onset of migraine symptoms. Bright sunlight and intense sun exposure, particularly when reflected off surfaces such as snow or water, are also recognized migraine triggers.

Also read: Global Temperatures Likely To Stay Near Record Levels For Next Five Years: WMO

How Does The Weather Trigger Migraines?

According to Dr. Kumar, weather changes can affect brain chemistry by influencing serotonin levels, a neurotransmitter involved in migraine development. They may also contribute to inflammation or pressure differences within the sinuses.

Further, the expert noted that seasonal transitions can be particularly challenging.

"Spring and summer may trigger migraines because of heat and allergens, while winter's cold and dry air can also contribute to headaches and sinus discomfort," he said.

Notably, weather is often only one factor among several. Allergies during spring or viral illnesses during autumn may also combine with environmental changes to trigger headaches, Dr. Kumar stressed.

Migraine Vs Sinus Headache

Read More: What Can You Learn About Your Health From Ice Cream Headaches?

Migraine is also frequently mistaken for a sinus headache because the symptoms often overlap.

Dr. Kumar noted that migraine attacks can cause forehead and facial pressure, as well as nasal congestion or a runny nose. Unlike migraine, however, sinus infections may be accompanied by fever.

He explained that migraine can activate nerves in the face, a phenomenon known as cranial autonomic activation, which can create sensations of nasal blockage and congestion.

While weather changes are difficult to avoid, monitoring weather forecasts may help people prepare for potential triggers. Preventive treatment may also reduce sensitivity to environmental changes and allow greater freedom in daily activities.

Tips To Prevent Migraine

Dr. Kumar advised:

• Keeping a migraine diary for at least 90 days to help identify specific weather-related patterns associated with attacks.
• Treating migraine attacks early when weather-related triggers are suspected. Early treatment can shorten the duration of an attack and prevent symptoms from becoming severe.
• Maintaining adequate hydration, particularly during hot weather or physical activity. Carrying water when outdoors can help compensate for fluid loss through sweating.
• For those sensitive to bright sunlight, staying indoors during peak daylight hours may be beneficial. When outdoor exposure is unavoidable, protective sunglasses or hats can help reduce glare and light sensitivity.

Pancreatic cancer is one of the most feared diseases, and it causes thousands of lives to be wasted away due to this fatal disease. According to the Population-Based Cancer Registries (PBCRs) managed by the Indian Council of Medical Research (ICMR) and the IARC Global Cancer Observatory (GLOBOCAN), about 22,982 Indians have pancreatic cancer every year.

On the other hand, the American Cancer Society's US SEER Pancreatic Cancer Stat Facts shows the annual number of cases is 67,530. Thus, any lead to resisting cancer is good news for the world. Recently, a research team from Stony Brook Medicine and Luisa Escobar-Hoyos of Yale School of Medicine, led by Kenneth Shroyer and Natalia Marchenko, found an important fact to fight the fatal disease.

The study investigated the role of Keratin 17 (K17) and found that the protein can be a driver of chemoresistance to gemcitabine. It is often used to treat various types of cancer. The study shows that the K17 can act as a target for the development of novel treatments.

They discovered that the protein is a key driver of chemoresistance to gemcitabine, an agent used to treat a wide range of cancers, including advanced tumors of the pancreas, lungs, and breast.

How New Pancreatic Cancer Drug Daxorrasib Can Help You?

Daxaronrasib is a daily oral pill that has demonstrated statistically significant and clinically meaningful improvements in progression-free survival (PFS) and overall survival (OS) compared with standard intravenous chemotherapy.

Described as a multi-selective inhibitor of RAS(ON) proteins, it is the first investigational drug in a new class of RAS inhibitors designed to target a broad spectrum of cancer-causing RAS mutations.

The drug works by blocking KRAS signalling proteins that drive tumor growth.

Read More: New Pancreatic Cancer Drug Daxaronrasib May Benefit Patients With Lung And Ovarian Tumors Too

Daraxonrasib is the first drug. It works by pairing up with a protein called cyclophilin A inside cells, acting like a molecular glue, glomming onto the mutated protein.

Pancreatic cancer is considered one of the most RAS-dependent cancers, with more than 90 per cent of patients carrying tumours driven by RAS protein mutations. Similar RAS-targeting drugs are also being developed for pancreatic, lung, and colon cancers.

The findings were presented at a plenary session of the American Society of Clinical Oncology’s meeting in Chicago on May 31 and simultaneously published in the New England Journal of Medicine.