We all enjoy a good slushie every now and then. While they do not add any great nutritional value to our meal, they are a delightful snack made with shredded ice and sugar. To make them more accessible to people who cannot or do not wish to have sugar, there are many sugar free options to pick from. However, a recent study has revealed that sugar-free slushies containing glycerol, which is a sugar alcohol used to maintain their icy texture, can cause severe health problems in young children. The study was published in the journal Archives of Disease in Childhood, it explains that having these sugar free slushies can lead to children having a condition called "glycerol intoxication syndrome". In this condition there is a rapid drop in blood sugar, reduced consciousness, and a buildup of acid in the blood.

Rapid Onset of Symptoms

Kids who drank slushies with glycerol got sick very quickly. Within an hour, they started showing serious symptoms. Their blood sugar would plummet, sometimes dangerously low. Many became confused or lost consciousness, and some even had seizures. Doctors studied 21 children who got sick from these drinks between 2018 and 2024. Most of these kids were very young, seven years old or younger. By the time they got to the hospital, many were in bad shape, either unconscious or barely awake. This quick reaction time makes it especially scary, as parents might not realize the slushy is the cause right away. It's important to recognize these signs fast.

Why is Glycerol Harmful?

According to WebMD Glycerol is a type of naturally occurring alcohol, and it's used in lots of food products. You might find it in protein bars, diet foods, and even sugar-free candies. In slushies, it plays a key role in keeping the drink icy. Usually, slushies use tons of sugar to stop them from freezing completely. But because people are trying to cut back on sugar, companies are using glycerol instead. This is especially true in places with "sugar taxes," where sugary drinks cost more. So, to make sugar-free versions, they add glycerol. This switch means more kids are being exposed to this ingredient, which can be harmful to them.

What Does Glycerol Damage Children's Health?

The study explains that little kids are more at risk from glycerol because their bodies are still growing and developing. Their tiny bodies and young metabolisms might not be able to handle glycerol as well as adults' bodies can. This means that even a small amount can cause a big problem. Also, the amount of glycerol in a slushy can vary, and it's hard to know exactly how much is safe. Factors like how fast they drink it, if they've eaten recently, or if they've been exercising can also make a difference. Even the standard size of a slushy drink can be too much for a small child. This makes it hard to give a safe dose.

Health authorities in the UK and Ireland have already started warning about glycerol in slushies. They suggest that kids under four shouldn't have them at all, and older kids should only have one at most. But doctors are worried that these warnings might not be enough. They point out that it's hard to know how much glycerol is actually in each drink, making it difficult to give safe advice. Parents are being told to be very careful and consider avoiding these drinks altogether for young children. In the US, glycerol is approved for use in food, but parents should still be aware of the potential risks. More research is needed to understand the full impact.

A sugar naturally found in red meat may help explain why beef and lamb have long been linked to type 2 diabetes, according to a large new study presented at the European Association for the Study of Diabetes’ Annual Meeting in Milan.

Researchers tracked nearly 90,000 adults with no history of diabetes or cancer through NutriNet-Sante, a long-running French health study, according to a release from the European Association for the Study of Diabetes (EASD). Over a median follow-up of 7.2 years, 966 participants developed type 2 diabetes.

The focus was a sugar called N-glycolylneuraminic acid, or Neu5Gc, found mainly in beef and lamb. People with the highest intake of meat-derived Neu5Gc had a 63% higher risk of developing type 2 diabetes than those with the lowest intake, the EASD reported. The risk rose steadily with intake: the second-highest group already carried a 41% higher risk.

“This is a relative risk: people in the top fifth of meat-derived Neu5Gc intake had a 63% higher risk than those in the bottom fifth, after accounting for many other factors,” said lead author Dr. Leopold Fezeu of Universite Sorbonne Paris Nord told Medical News Today. “It does not mean that 63% of high consumers will develop diabetes.”

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Why Scientists Suspect Inflammation

Most mammals produce Neu5Gc naturally, but humans lost that ability after an ancient genetic mutation, according to the EASD. The sugar can still enter the body through food and get absorbed into human tissue. Because the body doesn’t recognise Neu5Gc as its own, the immune system may treat it as foreign, producing antibodies against it in a prolonged immune response called xenosialitis, previously linked to cardiovascular disease and cancer.

“Our findings support chronic inflammation as a specific mechanism linking red meat consumption with T2D, partly beyond the amount of red meat a person eats and partly independent of body fat,” Fezeu said.

What Are The Key Findings?

Not just weight: Notably, obesity accounted for only about 13% of the link between Neu5Gc intake and diabetes risk, the EASD reported, suggesting the sugar’s effects may extend beyond weight gain alone.

Dairy showed no link: Despite also containing Neu5Gc, dairy products showed no association with diabetes risk, likely because cow’s milk contains far smaller amounts than red meat.

An important caveat

When researchers additionally adjusted for total red meat intake, the Neu5Gc-diabetes link weakened and was no longer statistically significant, though it pointed the same direction.

“There may be differences between sources, or other components of red meat may contribute,” Fezeu said, meaning the study can’t fully separate Neu5Gc’s effect from red meat generally.

What comes next

Since the study is observational, it cannot prove Neu5Gc causes diabetes. Fezeu’s team plans to measure antibodies against Neu5Gc directly and study how it interacts with iron in red meat.

“Future research should explore whether reducing exposure to meat-derived Neu5Gc, for example by favoring poultry or plant-based proteins over beef and lamb... could help prevent T2D,” Fezeu said.

As we brace ourselves for another bout of winter, we can’t help but feel wary about the changes the dip in temperature brings on our mood and mental well-being. You are not imagining winter depression when you start to feel sudden loss of joy.

Seasonal depression is more than feeling gloomy. You may no longer enjoy the activities you once relished, like listening to music, exercising or meeting friends. This isn’t just another effect of winter. Experts have designated a term for it: anhedonia.

Anhedonia refers to the loss of pleasure or interest in something you once enjoyed. It is one of the symptoms of depression, including seasonal affective disorder (SAD). Unlike sadness, anhedonia can render someone feeling disconnected with or indifferent towards things they once enjoyed.

A person experiencing anhedonia may still participate in activities they enjoy but will no longer reap emotional rewards from it.

“Anhedonia is not the kind of sadness where you’re feeling down but still have moments of enjoyment,” Dr Deeksha Kalra, Associate Consultant, Psychiatry, Artemis Hospital, Gurugram, explained to HealthandMe.

Dr Samant Darshi, Consultant Psychiatrist and Neuromodulation Expert at Yatharth Hospitals, told us, “While sadness entails the state of feeling unhappy about something, anhedonia pertains to the lack of enjoyment.”

Dr Kalra said, during SAD, anhedonia may be experienced during the affected season like winter.

“This can happen at the same time as low mood, but it can also be one of the clearest symptoms. In SAD, these changes are usually present during the affected season and resolve with the resolution of the depressive episode. So anhedonia is about muted pleasure, not just feeling sad,” Dr Kalra explains.

Effects Of Winter On Pleasure And Motivation

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Changes that come with SAD, a type of depressive phase, usually pertains to specific seasons, like mostly winter. Due to less duration of daylight, the body’s internal clock, known as circadian rhythm, may get affected. Along with circadian rhythm, poor diet, irregular sleep pattern and limited physical activity can also contribute to SAD.

This could cause one to feel difficult to initiative activities they enjoy as they no longer feel motivated, affecting the brain reward system.

“Seasonal affective disorder (SAD) causes disturbance of mood, sleep, energy, and motivation. Activities which were pleasurable before become less rewarding because of this. The changes in daylight hours may affect the body clock or the physiological processes related to mood control. The decrease in energy and motivation makes doing the activity even harder and less pleasurable,” said Dr Darshi.

Dr Kalra explains that there are a lot of phases to experiencing ‘enjoyment’. It involves identifying something rewarding, anticipating it, experiencing pleasure and learning from the experience. Depression can affect all these phases, making previously enjoyable activities feel less rewarding.

“Brain networks including the striatum and nucleus accumbens, contribute to the valuation of rewarding experiences and the motivation of behavior. When their responses are dulled and something that was once naturally rewarding may not have the same emotional resonance,” she says.

Dopamine’s Role In SAD

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Dopamine is a neurotransmitter in the brain responsible for motivation, rewards, learning, and directing behaviour as per goals. When we talk about SAD and anhedonia, dopamine comes into the picture as it is related to motivation and rewards.

Dr Kalra explained, “Dopamine is involved in motivation, reward anticipation, learning and determining the value of pursuing something. That’s why dopamine has been looked at when researchers have investigated anhedonia and low motivation.”

But doctors say that anhedonia is not characterised by shortage of dopamine. According to research, SAD has been reported to affect dopamine signalling, including lower dopamine transporter availability in the striatum during symptomatic depression.

Dr Darshi also emphasises that dopamine is only a part of the process.

He said, “Studies concerning depression and anhedonia indicate that changes in the activity of dopamine result in the decrease in motivation and reward sensitivity. However, anhedonia encompasses many brain processes.”

SAD And Anticipatory Pleasure

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Anhedonia makes one indifferent by directly affecting the anticipatory pleasure mechanism. Anticipatory pleasure is the excitement one feels before an event. Consummatory pleasure is the enjoyment experienced while the event is in progress.

“Anhedonia can affect the anticipatory pleasure you feel when you look forward to something and the consummatory pleasure you experience when it actually happens. Someone might know that a favorite meal, holiday or meeting with friends should be enjoyable but feel little excitement beforehand. The pleasure might also feel weaker than expected when the event happens,” Dr Kalra explains.

Not Everyone May Experience Same SAD Symptoms

Everyone with SAD experiences anhedonia in different ways. While some may lose interest and pleasure, others may withdraw socially, sleep excessively, eat more, feeling more tired among other symptoms.

“SAD doesn’t affect everybody in exactly the same way any more than depression is a single biological process. Different people can experience different combinations of changes in mood regulation, circadian rhythms, sleep, appetite and energy and reward processing,” says Dr Kalra.

She also said that multiple symptoms may interact. For example, poor sleep could result into daytime sluggishness, making energetic activities less tempting.

Dr Darshi explained, “Individuals with SAD have different presentations since biology, genetics, circadian rhythm, and psychology are unique for each person. Some individuals have disturbances in reward and motivation, whereas others have sleep disturbances or carbohydrate cravings, or even fatigue. Symptoms might be overlapping and are a reflection of various underlying mechanisms.”

Female breast cancer was the most commonly diagnosed cancer among women in India in 2024, with an estimated 237,231 new cases and 96,100 deaths, according to the International Agency for Research on Cancer (IARC).

Despite the importance of early detection, screening uptake remains low. Experts say India needs better access to screening and approaches tailored to age, breast density and individual risk.

Dr. Sandeep Nayak, Chairman of Oncology at MACS-Renova Oncology Institute, KIMS Hospital, Bengaluru, told HealthandMe that population-wide screening remains a distant goal, with opportunistic screening still the norm.

“Because of this, applying blanket Western guidelines is ineffective. We need a pragmatic, age-stratified approach to imaging: utilizing breast ultrasound (USG) for women aged 35 to 45—where dense breast tissue severely limits mammogram sensitivity—and reserving routine mammography for women above 50, where tissue density decreases and diagnostic yield peaks,” he said.

Why Is Breast Cancer Still Diagnosed Late in India?

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“The alarming epidemiological paradox is that while our incidence is a third of Western nations, our death rate already surpasses theirs. The issue is not that this cancer has an aggressive biology in India; it is the timeline of discovery,” said Dr. Navin Gnanasekaran, Head of Clinical Services, Radiology and Interventional Radiology for the Apollo Group Chennai Region.

Dr. Gnanasekaran said more than 60% of breast cancers in the United States are diagnosed while still localized, with five-year survival exceeding 90%. In India, many cases are detected after the cancer has spread beyond the breast, contributing to a five-year survival rate of 66.4%, he said.

India introduced population-based screening for common noncommunicable diseases in 2016 under the National Program for Prevention and Control of Cancer, Diabetes, Cardiovascular Diseases and Stroke (NPCDCS), launched in 2010. The program includes breast cancer screening among women aged 30 and above.

However, National Family Health Survey-5 (NFHS-5) data show that only 0.9% of women aged 30–49 had ever undergone a breast examination for cancer detection. Dr. Gnanasekaran placed the median age of breast cancer onset in India at around 45.

Should Mammograms Start at 40—or Later?

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Experts differ when routine mammography should begin and whether breast density should influence imaging choices.

Dr. Gnanasekaran recommended digital mammography every two years for women aged 40–60. He proposed linking screening reminders to Ayushman Bharat Health Account (ABHA) IDs, deploying mobile mammography units in rural areas and using validated artificial intelligence (AI) to help interpret scans.

Dr. Nayak recommended ultrasound for women aged 35–45 and routine mammography for those above 50.

Dense breast tissue can make some cancers harder to detect on mammograms. Women at high genetic risk, including those with BRCA mutations or a strong family history, may need earlier surveillance, potentially including contrast-enhanced breast MRI in their late 20s or early 30s, depending on individual risk.

Dr. Gnanasekaran stressed that screening must be supported by accessible diagnostic and treatment services, including timely biopsies.

Is Mammography Safe, and Can It Miss Cancer?

Mammography can miss some cancers, particularly in women with dense breasts. Ultrasound may be added for dense breasts or specific concerns, while MRI is generally used for women at higher risk or in selected situations.

Dr. Garvit Chitkara, Associate Director of Breast Surgical Oncology and Oncoplasty at Nanavati Max Institute of Cancer Care, Mumbai, said the radiation risk from mammography is low, while false-positive results can lead to additional tests.

“At the recommended intervals, mammography does not meaningfully raise your cancer risk. The more real downsides are occasional false alarms that lead to extra tests, which is a reason to have it done at a good centre and discuss any call-back with your doctor,” he told HealthandMe.

A normal mammogram should not be used to dismiss a persistent lump or other breast symptoms. Women experiencing changes should seek medical evaluation even if their most recent screening result was normal.

Which Breast Changes Should You Never Ignore?

Many breast lumps are benign, including cysts and fibroadenomas, but touch alone cannot reliably distinguish a harmless lump from cancer.

“Any new lump, or a lump that is changing in size or feel, should be examined by a doctor. A quick check usually settles it and gives you peace of mind,” Dr. Chitkara said.

Persistent redness, itching or skin thickening, breast dimpling, puckering, an orange-peel texture, nipple retraction or unusual nipple discharge should also be evaluated.

Early breast cancer is often painless. Women should not wait for pain before seeking medical attention.