An unusual medical condition has caught the attention of doctors and the public. Argyria, a rare disorder caused by the accumulation of silver in the body, has left people with a permanent gray or blue-gray skin tone. Though such a transformation might seem like a scene from a science fiction movie, it is very real—and the effects are long-lasting.

In this article, we shall look at the causes, symptoms, diagnosis, and treatment of argyria. We shall also address its risks, preventive measures, and new research on the condition.

Argyria is a condition resulting from the long-term accumulation of silver in the human body, leading to the permanent discoloration of skin, eyes, and other tissues especially when exposed to sunlight. This condition results primarily from the overexposure to silver particles due to occupation or ingestion of compounds containing silver.

A case that gained much attention was that of an 84-year-old man in Hong Kong, whose ashen color complexion resulted from his exposure to silver. This man had initially been admitted to the hospital upon noticing a change in his skin color. Through further analysis, silver granules were identified within his skin tissues, blood vessels, and sweat glands. His blood tests revealed that his serum silver concentration was 40 times higher than normal, and he was diagnosed with argyria. Although he claimed to have no direct exposure to silver, the case revealed the hidden dangers of silver accumulation in the body.

How Does Silver Accumulate in the Body?

Most frequently, argyria is caused due to the ingestion and inhalation of silver or a compound containing the metal. As the silver particulates enter through the bloodstream in such cases, silver deposits in nearly all tissues- skin, liver, kidneys, lungs, spleen, or even the brain.

The commonest symptom presenting in argyria is, of course when silver accumulates in the skin. Light-exposure to silver triggers a form of photoreduction with the ultraviolet components of sunlight to take on a tinge of bluish or even grayish skin. This has also been implicated in other sites, including those in the fingernails and gums, plus the eyes of some patients who develop this. Internal organs sometimes take on blueish tinges, such as the liver or spleen but only through X-rays or another medical imaging modalities.

Who Is Likely to Get Argyria?

Argyria is currently an infrequent disease, though historically, the prevalence was more pronounced. This is mainly because during the 19th century, most people had intensive exposure to silver. Some common uses of silver during the same period were its application in various industries like mining and processing and as medication. The present leading causes of argyria include:

Ingestion of Colloidal Silver

Colloidal silver is a liquid solution that has tiny particles of silver, which is mostly sold as a dietary supplement. Those who ingest colloidal silver for purported health benefits—used allegedly to boost the immune system to treat everything from diabetes and cancer—risk argyria. The use of colloidal silver has not been supported by scientific research; experts in health also warn consumers from using such.

Work Exposure

People working in silver-related industries like silver mining, manufacturing, or jewelry making. If the workers have an extended exposure to silver particles suspended in the air or deposited on the skin.

Prolonged use of medication that contains silver compounds as a component. An example of such medication is eyedrops or nasal sprays. Silver accumulation in the body may occur with a prolonged duration of medication use.

Genetic predisposition

Some rare genetic factors may predispose a few people to the condition.

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Symptoms of Argyria

The main symptom of argyria is the gradual appearance of bluish-gray or grayish discoloration of the skin, mainly in areas exposed to sunlight. The color change is permanent and may cause psychological distress in most patients. Other symptoms of argyria include:

• As silver builds up in the body, fingernails may darken.
• Dark spots may appear on the skin, especially in skin areas that receive regular exposure to sunlight.
• The whites of the eyes (sclera) turn a bluish-gray color.
• In some cases, argyria patients may report mild symptoms including stomach discomfort, fatigue, or headaches.
• Over time, internal organ damage such as the liver, spleen, and kidneys may occur due to silver buildup; however, these symptoms are not always observable.

The condition is not fatal, but the symptoms may be uncomfortable, and the discoloration is permanent.

How is Argyria Diagnosed?

Argyria is usually established by a case history, medical examination, and laboratory tests. A crucial diagnostic method is to undertake a biopsy on the affected areas of the skin, which, in turn can show silver particles in the tissue. Blood examination can also tell the concentration level of silver inside the blood of the patient after the diagnosis. After establishing this diagnosis, another step is toward the cause or reason behind deposition of silver.

Treatment and Management

Currently, there is no treatment for argyria. The coloration due to the condition is irreversible. However, there are several measures to help manage the appearance of the condition:

• Regular application of sunscreen can prevent the coloration from worsening since exposure to UV rays accelerates the photoreduction process.
• Though not universally successful, some patients have undergone laser therapy to minimize the appearance of the coloration, though success varies.
• Many individuals use makeup to cover the grayish tint of their skin and restore a more natural appearance.
• Some topical treatments, such as 5% hydroquinone, may help lighten the skin and reduce the appearance of the discoloration.

In addition to cosmetic treatments, it is essential for individuals to avoid further exposure to silver or silver-containing compounds to prevent the condition from worsening.

Is Argyria Preventable?

Preventing argyria is largely about avoiding unnecessary exposure to silver. If you are taking dietary supplements or medications that contain silver, consult with your healthcare provider to explore alternative options. People who work with silver should ensure that their workplace adheres to safety regulations, such as the Occupational Safety and Health Administration’s (OSHA) exposure limits for silver dust.

Argyria is a rare but serious condition that can have a significant impact on an individual’s appearance and well-being. Although modern exposure to silver is less common than in previous centuries, certain lifestyle choices, such as using colloidal silver as a supplement or working in silver industries, still pose a risk. Understanding the causes, symptoms, and prevention of argyria is key to minimizing its impact on health. Although it has no known cure, precautions and proper remedies can be availed to lessen the impact brought about by the condition.

Argyria an unrecognized cause of cutaneous pigmentation in Indian patients. Indian J Dermatol Venereol Leprol. 2013

ARGYRIA. JAMA Network. 1937

Argyria. The New England Journal of Medicine. 2025

India has reported its second human fatality due to highly pathogenic avian influenza (HPAI) or bird flu, marking the first such death in four years. While bird flu infections in humans are rare, they are highly lethal, with a fatality rate of one in two cases. The most recent victim was a two-year-old girl from Palnadu, Andhra Pradesh, who passed away in mid-March after being hospitalized for over 10 days at the All India Institute of Medical Sciences (AIIMS), Mangalgiri.

The pathogen responsible for the infection and subsequent deaths was confirmed only on 31 March, following a survey by the Indian Council of Medical Research-National Institute of Virology (ICMR-NIV). According to details shared by the state government, the child, who had a habit of consuming raw chicken, was admitted to the hospital on 4 March with symptoms including fever, breathlessness, nasal discharge, seizures, diarrhea, and reduced feeding. Two days before falling ill, she had reportedly consumed raw chicken. She succumbed to the infection 12 days later.

In a statement issued on Wednesday, the state government noted that no abnormal cases of respiratory infections had been identified in the ongoing survey. However, surveillance will continue for the next two weeks, with testing arranged for any suspected cases. Union health ministry officials stated that, based on data from the Integrated Disease Surveillance Programme (IDSP), no unusual surge in influenza-like illness (ILI) or severe acute respiratory illness (SARI) cases has been observed in the district in recent weeks.

A national joint outbreak response (NJOR) team has been deployed to conduct an epidemiological investigation and provide assistance to the state.

3 States Impacted By Bird Flu

This year, outbreaks of HPAI—also known as Influenza A virus subtype H5N1 or bird flu—have been reported in Maharashtra, Karnataka, and Andhra Pradesh. The trend follows a similar pattern observed in 2024, when states such as Jharkhand and Kerala, along with the aforementioned three states, recorded widespread H5N1 infections in poultry, prompting authorities to cull thousands of birds.

The Union government emphasized that "human-to-human transmission of the H5N1 virus is uncommon, and the risk of any other epidemiologically linked case being reported is assessed to be low."

India's first recorded human infection of the H5N1 influenza virus occurred in 2021 when an 18-year-old boy in Haryana succumbed to the infection within days of contracting it.

In May last year, Australia reported its first human infection with H5N1, stating that the patient had acquired the virus in India. Towards the end of 2024, the deaths of four big cats—three tigers and a leopard—were attributed to H5N1 infection.

Oxytocin, commonly referred to as the "love hormone" because it is involved in bonding and social behavior, is now being investigated for its surprise effect on pregnancy. Although oxytocin is traditionally linked to childbirth, milk letdown during lactation, and emotional bonding, recent findings indicate that this hormone can possibly delay early pregnancy. A study on mice conducted recently has helped explain how the hormone can stop embryonic growth, which may provide new understanding of human fertility and pregnancy.

In a few mammals, such as marsupials, bats, and more than 130 others, a process called "diapause" takes place. This is a natural biological phenomenon that sees embryos suspend their development in order to wait until the right conditions prevail for pregnancy to resume. Although very uncommon and hard to monitor in human beings, clinical experience from in vitro fertilization clinics indicates that human embryos might at times show delayed implantation. One highly documented case in 1996 showed that an embryo implanted in a uterus was in a suspended state for five weeks before implantation took place.

The new research by scientists at the NYU Grossman School of Medicine investigated oxytocin's possible role in inducing this pause in pregnancy. Their results indicate that oxytocin could be a major player in controlling diapause in mice, and they raise questions about its possible role in human pregnancies.

Oxytocin-Induced Pregnancy Pause

To study the impact of oxytocin on pregnancy, scientists tested female mice who had recently given birth by letting them be mated while still lactating. The research revealed that nursing females had pregnancies that lasted about a week longer than those of the non-nursing mice. Since the normal pregnancy in mice takes only 19 to 21 days, this postponement is a drastic halt to embryonic development.

The research team then sought to determine how this pause occurred. Using optogenetics, a technique that enables the activation of specific neurons through light stimulation, they artificially triggered the release of oxytocin in pregnant mice. After five days of oxytocin stimulation, the researchers examined the mice’s uteruses and found that five out of six had embryos in a dormant state, indicative of diapause. Conversely, pregnant mice that were not administered oxytocin stimulation did not exhibit any indication of developmental arrest.

In further confirmation of their research findings, the scientists administered oxytocin to early-stage mouse embryos in the laboratory setting. They detected identical cellular alteration related to diapause, implying that oxytocin has a direct influence on suspended embryonic development.

How Oxytocin Affects Embryonic Development?

The research showed that oxytocin slows down the process through which embryonic cells convert genetic information into proteins. This process, essential for growth and development of the cell, is copying DNA instructions into RNA, which then guides protein synthesis. By suppressing this process, oxytocin puts the embryo into suspended animation.

Interestingly, scientists also learned that embryos without oxytocin receptors were still able to enter diapause, suggesting that more than one biological pathway is used to trigger the pause. Still, having working oxytocin receptors seemed to increase the embryo's chances of surviving the halted state. When oxytocin receptors in the embryos were deactivated, survival rates while in diapause fell to 11% from 42%.

Implications for Human Fertility and Pregnancy

Although this research is in its infancy, it presents exciting possibilities for human fertility studies. A better grasp of the role oxytocin plays during early pregnancy may lead to significant advances in treating unexplained infertility and recurrent miscarriage. If human embryos can enter a state of diapause, further study could reveal how hormonal or environmental influences are responsible for early pregnancy loss.

Also, these discoveries may have greater implications outside pregnancy. As oxytocin is implicated in cell survival, researchers now want to know if what it does in diapause can help understand how to keep nerve cells from dying in the developing nervous system. What stops cells from dying early on might help neurobiology and regenerative medicine advance.

Even with these thrilling findings, much remains to be answered. How long can diapause be in various species, including humans? What are other biochemical signals that cooperate with oxytocin to control embryonic development? And might this information one day lead to targeted fertility treatments or interventions?

More studies are needed to uncover these secrets. As researchers learn more about the multifaceted functions of oxytocin, its image as just the "love hormone" is changing. This potent molecule seems to play a much more intricate function in reproductive biology than has been known, and it may play a role not only in when life starts, but in when it temporarily gets suspended.

Oxytocin's role in pregnancy is turning out to be more complex than originally thought. Though still a primary force behind labor and maternal attachment, it has also recently been found to retard embryonic development, which could have far-reaching consequences for reproductive science. As more research unfolds, the hormone could provide new insights into fertility, enhance IVF success, and even prevent early miscarriage. The possibility of oxytocin-based fertility therapies is an exciting one, and future research will be important to determine how this information can be translated to human pregnancy.

A study published in the New England Journal of Medicine has listed five key factors that impact the longevity of individuals. The research tracked participants for up to 47 years, assessing how five specific factors influenced their risk of death, longevity, and the number of healthy years they could gain by altering these habits. The conclusions of this study were based on data analyzed from over two million adults aged 18 and above across 39 countries.

Five Factors That Influence Longevity

• High blood pressure
• High cholesterol
• Diabetes
• Smoking
• Bodyweight, including being overweight and underweight

Women Could Add 14 Years To Their Lives

As per the researchers, women who didn't have these five risk factors at age 50 could potentially add more than 14 years to their lives, and men could gain almost 12 additional years. Men were most affected by these factors as those with all five faced a 94% chance of dying before 90, while their counterparts without these issues had just a 68% chance. Women with all five risk factors at age 50 had an 88% chance of dying before 90, whereas those without these problems had a 53% chance.

Diabetes Is The Main Factor

Out of all the factors, cholesterol was the least impactful of all. As per the study, people who lowered their cholesterol levels could only add 1.2 extra healthy years to their lifespan. On the contrary, individuals who quit smoking could potentially extend their lives by up to six years. Women who do not have diabetes could gain an extra 6.4 years, while men without the condition might see an increase of 5.8 years. Even a slight reduction in blood pressure could lead to an additional 1.8 healthy years, and achieving a normal BMI could contribute an extra 2.6 years, with variations depending on the region.

Importance Of Lifestyle Changes

The study reinforces the importance of lifestyle modifications in extending a healthy lifespan. The researchers noted that small but consistent changes in daily habits could significantly impact longevity. For example, maintaining an optimal weight through a balanced diet and regular physical activity helps control blood pressure, diabetes, and cholesterol levels, reducing overall health risks.

Smoking cessation emerged as the most crucial lifestyle change that could dramatically influence lifespan. Quitting smoking, even later in life, significantly reduces the risk of cardiovascular diseases, lung disorders, and certain cancers, contributing to longer and healthier lives. Similarly, diabetes management through dietary changes, regular exercise, and proper medical intervention plays a vital role in preventing complications and enhancing longevity.

Regional And Gender-Based Differences

The study also highlighted variations in longevity gains based on gender and geographical regions. For instance, men were more susceptible to the adverse effects of these five risk factors than women. This disparity could be attributed to lifestyle differences, genetic predisposition, or healthcare access.

Additionally, in certain countries with high obesity rates, maintaining a normal BMI was one of the most significant contributors to longevity. Meanwhile, in regions with lower tobacco consumption, factors like high blood pressure and diabetes had a more prominent role in affecting lifespan.