Regular Blood Donation May Influence Cancer Risk

Updated Mar 12, 2025 | 11:00 PM IST

SummaryAs and when people age, their blood and other cells naturally develop mutations and some of them can also increase the risk of cancer. When anyone donates blood, his or her body compensates by producing new blood cells, which can influence the genetic diversity of stem cells in the bone marrow.
Can blood donation reduce cancer risk?

Credits: Canva

A recent study suggests that people who donate blood regularly may have genetic changes in their blood that could in fact reduce the risk of developing cancer. It is conducted by the researchers at the Francis Crick Institute, and the study has now provided new insights into how and why blood cancers develop. The study is published in the journal Blood and was conducted by the scientists from Heidelberg and the German Red Cross blood donation center. There is yet a need for further research to confirm these findings.

What Did The Study Find?

The researchers examined the blood of two groups of healthy male donors in their 60s:

  • One group had donated blood three times a year for 40 years.
  • The other group had donated only about five times in total.

The goal was to analyze genetic mutations in their blood and assess whether frequent donation had any impact on their genetic makeup.

How Can Blood Donation Affect Stem Cells?

As and when people age, their blood and other cells naturally develop mutations and some of them can also increase the risk of cancer. When anyone donates blood, his or her body compensates by producing new blood cells, which can influence the genetic diversity of stem cells in the bone marrow. The study also found that both groups had a similar number of mutations. For instance the frequent donors had 217 mutations, while the irregular donors had 212 mutations.

However, the nature of these mutations differed. In the frequent donors, 50% of the mutations were of a type not associated with a high risk of blood cancers, compared to only 30% in the irregular donors.

Further laboratory analysis showed that these specific mutations behaved differently from those linked to leukemia, a type of blood cancer. When human blood stem cells with these mutations were injected into mice, they were found to be highly effective at producing red blood cells, which is considered a positive outcome.

Dr. Hector Huerga Encabo, one of the study authors, emphasized that these mutations do not indicate an increased risk of leukemia. The findings suggest that regular blood donation may influence how stem cells evolve, but whether this translates into a lower cancer risk remains uncertain.

Read More: Who Can Donate Blood To Whom?

Limitations

One notable disadvantage is the "healthy-donor effect"—because blood donors are often healthier than the general population, their lower cancer risk could be unrelated to blood donation.

Dominique Bonnet, senior researcher and head of a stem-cell laboratory at the Francis Crick Institute, stressed the need for larger studies with female volunteers to confirm the findings.

Despite ongoing research into potential health benefits for donors, the primary goal of blood donation remains saving lives. NHS Blood and Transplant emphasized that while the study is interesting, further research is required to draw firm conclusions. The organization also noted that blood supplies are currently critically low and encouraged eligible individuals to donate.

Also Read: How Long After a Tattoo or Piercing Can I Donate Blood?

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Breastfeeding Can Help Prevent 400,000 Child and 140,000 Maternal Deaths Annually, Says WHO

Updated Aug 1, 2026 | 12:00 AM IST

Summary​The 2026 theme, "Breastfeeding for a Sustainable Start in Life: Strengthen What Works," focuses on tracking progress, evaluating impact, and scaling proven approaches that improve breastfeeding outcomes.
Breastfeeding Can Help Prevent 400,000 Child And 140,000 Maternal Deaths Annually, Says WHO

Credit: WHO

Breastfeeding is important not only for babies' health and nutrition but also for protecting mothers from serious diseases, the World Health Organization (WHO) said.

It urged governments to strengthen access to services and interventions that support breastfeeding as part of World Breastfeeding Week, observed annually from August 1–7.

The 2026 theme, "Breastfeeding for a Sustainable Start in Life: Strengthen What Works," focuses on tracking progress, evaluating impact, and scaling proven approaches that improve breastfeeding outcomes.

Breastfeeding Could Save Hundreds of Thousands of Lives

"Scaling up breastfeeding could prevent almost 400,000 child deaths and around 140,000 maternal deaths each year," said UNICEF Executive Director Catherine Russell and WHO Director-General Dr. Tedros Adhanom Ghebreyesus in a joint statement.

"Every US$1 invested in breastfeeding promotion generates an estimated US$59 in economic returns through lower health-care costs, improved cognitive development, higher educational attainment, and increased lifetime earnings," they added.

Health Benefits for Babies and Mothers

The experts noted that breastfeeding is one of the simplest and most powerful ways to protect a child's health. It provides infants and young children with essential nutrition, boosts immunity, helps protect against serious illnesses, and supports cognitive development.

For mothers, breastfeeding also offers significant health benefits by reducing the risk of noncommunicable diseases such as breast and ovarian cancers, and type 2 diabetes.

Global Breastfeeding Rates Have Improved

The WHO said breastfeeding rates have improved globally due to sustained investments in policies and programs supporting mothers and families.

Exclusive breastfeeding during the first six months increased from around 37 per cent in 2012 to more than 47 per cent today. Over the past five years, the prevalence of breastfeeding up to two years of age has risen from 38 per cent to 50 per cent.

Progress Remains Uneven

Despite these gains, the WHO said many countries continue to lag behind global targets.

"Coverage of services supporting breastfeeding remains low, policies are inconsistently enforced, and service quality is often inadequate, especially in low-income, fragile, and humanitarian settings," the WHO said.

The agency noted that cost-effective interventions include skilled breastfeeding support within health systems, community-based counselling, maternity protection policies, and protection from the exploitative marketing of commercial milk formulas.

WHO, UNICEF Call for Stronger Support

WHO and UNICEF called on governments, health systems, workplaces, communities, civil society organizations, and families to strengthen the "Warm Chain of Support" for breastfeeding.

During World Breastfeeding Week, the agencies urged countries to:

  • Strengthen health systems to provide quality breastfeeding support for mothers and newborns.
  • Expand community-based counselling and peer support programs.
  • Fully implement and enforce the International Code of Marketing of Breast-milk Substitutes.
  • Invest in paid maternity leave and supportive workplace policies.
  • Integrate breastfeeding interventions into antenatal, perinatal, and postnatal health-care services.
  • Sustain breastfeeding support in humanitarian and fragile settings.

"Breastfeeding is vital. By investing in proven solutions, we can give every child the best possible start in life and ensure every mother gets the care and services she needs," the agencies said.

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What Is Driving India's High Burden Of Childhood Cancers?

Updated Jul 31, 2026 | 09:56 PM IST

SummaryIn most children, cancer develops because of genetic changes that occur during early development. These changes are usually not linked to lifestyle factors or inherited from parents.
What Is Driving India's High Burden Of Childhood Cancers?

Credit: iStock

A new study published in The Lancet Regional Health–Southeast Asia has found that India accounts for 68% of all childhood cancer cases in the SAARC region.

While the country's large child population contributes to the high numbers, experts say underdiagnosis and incomplete cancer registration may mean the actual burden is even greater.

An international team of researchers, including from the US, India, and Canada, estimated that nearly 37,700 children aged up to 14 years were diagnosed with cancer across South Asia in 2022, with 17,700 deaths reported. India alone accounted for an estimated 25,939 cases and 12,028 deaths.

The researchers noted that because cancer registration remains incomplete, particularly in rural areas, the true number of childhood cancer cases in India could exceed 50,000 annually.

India's Large Child Population Drives Numbers

India is home to more than 380 million children, accounting for nearly 69% of the child population in the SAARC region. This naturally contributes to the country's higher share of childhood cancer cases and deaths.

However, experts emphasize that population size is only part of the explanation. Delayed diagnosis, limited access to specialized treatment, and gaps in cancer registration continue to affect both disease estimates and patient outcomes.

Leukemia Most Common Cancer

Dr. Narendra Agrawal, a leading Hematologist and Bone Marrow Transplant Physician and Senior Consultant and Unit Head of Haemato-Oncology at Rajiv Gandhi Cancer Institute & Research Centre, told HealthandMe that childhood cancer remains a major public health concern in India.

"Current estimates suggest that around 70,000–80,000 children and adolescents develop cancer each year, although the exact number remains uncertain due to expanding cancer registration systems". The most common childhood cancers in India include:

  • Leukemia
  • Lymphomas
  • Brain tumors
  • Bone tumors

What Causes Childhood Cancer?

Unlike many adult cancers, most childhood cancers do not have a clearly identifiable or preventable cause. Dr. Agrawal explained that, in most children, cancer develops because of genetic changes that occur during early development. These changes are usually not linked to lifestyle factors or inherited from parents.

Recognized Risk Factors

Although the causes of most childhood cancers remain unclear, some well-established risk factors include:

  • Ionizing radiation: High-dose exposure before birth or during childhood increases the risk of leukemia and certain other cancers.
  • Genetic syndromes: Conditions such as Down syndrome, Li-Fraumeni syndrome, and neurofibromatosis increase susceptibility to specific childhood cancers.
  • Certain infections: Epstein–Barr virus (EBV) is associated with some lymphomas, HIV increases lymphoma risk, and chronic hepatitis B infection raises the risk of liver cancer.
  • Environmental and parental exposures: Tobacco smoke, certain chemicals, pesticides, and some occupational exposures have been investigated as possible risk factors, although evidence remains inconclusive.

Challenges Beyond Disease Burden

Dr. Agrawal said India's substantial childhood cancer burden is largely driven by its population size. However, improving outcomes requires addressing several systemic challenges.

Key issues include:

  • Delayed diagnosis
  • Limited access to specialized pediatric oncology services in some regions
  • Treatment abandonment
  • Incomplete cancer registration
According to the expert, overcoming these barriers is essential to ensuring earlier diagnosis, better treatment access, and more accurate estimates of childhood cancer across the country.

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Lung Nodule on CT Scan? Doctors Explain When You Should Worry

Updated Aug 1, 2026 | 09:00 AM IST

SummaryA lung nodule on a CT scan is usually harmless. Experts explain common causes, cancer risk factors, warning signs, and why timely evaluation prevents unnecessary anxiety and enables early detection.
Lung Nodule on CT Scan? Doctors Explain When You Should Worry

Credit: AI Generated Image

A small spot on a lung CT scan can be alarming, with many people immediately fearing the worst. However, doctors say that a lung nodule is a common finding and, in most cases, is not cancer. On , specialists explain what lung nodules are, why they appear, which features may warrant closer evaluation, and how timely diagnosis can help detect serious conditions early and prevent unnecessary anxiety.

Dr. Gyanendra Agrawal, Senior Director - Interventional Pulmonology & Pulmonary Intensive Care, Max Super Speciality Hospital, Noida, told Health and me, "It is essential to talk about one of the most serious concerns of the patients who have undergone a CT scan on World Lung Cancer Day, oftentimes linked with the description of a spot/nodule found in the lungs. Some people see this term in the report and are gripped by fear; unfortunately, not all spots in the lung signify lung cancer."

According to Dr. Vinayak Maka, Senior Oncologist, Department of Oncology, Ramaiah Memorial Hospital, "A lung nodule is a small, round or oval-shaped growth in the lung, typically less than 3 cm in size, most often discovered incidentally during a chest X-ray or CT scan done for an unrelated reason."

Also Read: Rare Tick-Borne Bourbon Virus Detected In New York For The First Time

Notably, nodules are extremely common; many people carry one without ever knowing it, and without it causing any symptoms. They can form due to a wide range of causes, including old infections, inflammation, scar tissue, or benign growths. In a smaller proportion of cases, a nodule may represent an early cancerous growth, which is why understanding its characteristics matters.

"A lung nodule finding on a CT scan often triggers panic, but the reality is reassuring: over 95% of lung nodules are benign, arising from old infections, scars, or inflammation. Still, understanding when a nodule warrants concern can be lifesaving." Dr. Vinayak Maka added.

What Determines Risk?

Size is the key factor when assessing a lung nodule, alongside the patient's overall health. Nodules smaller than 6 mm have a very low cancer risk (under 1%) and usually only need routine follow-up. Those measuring 6–8 mm carry a slightly higher risk (1–2.5%) and are typically monitored with a repeat CT scan after 6–12 months.

On the other hand, Dr. Shyam Krishnan, Lead Consultant, Clinical & Interventional Pulmonology, CMRI (CK Birla Hospitals), Kolkata, told Health and me, "This World Lung Cancer Day, my message is simple. Do not ignore the shadow on your scan — but do not be paralysed by it either. Get it checked by people who can tell you exactly what it is. In lung cancer, a precise and early answer is the single most powerful thing we have. And that answer is now closer, gentler, and faster than most people realise."

Finding a lung nodule does not automatically mean a diagnosis of lung cancer. Experts stress that the size, appearance, and a person's medical history all play a role in determining the next steps.

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