A recent study suggests that people who donate blood regularly may have genetic changes in their blood that could in fact reduce the risk of developing cancer. It is conducted by the researchers at the Francis Crick Institute, and the study has now provided new insights into how and why blood cancers develop. The study is published in the journal Blood and was conducted by the scientists from Heidelberg and the German Red Cross blood donation center. There is yet a need for further research to confirm these findings.

What Did The Study Find?

The researchers examined the blood of two groups of healthy male donors in their 60s:

• One group had donated blood three times a year for 40 years.
• The other group had donated only about five times in total.

The goal was to analyze genetic mutations in their blood and assess whether frequent donation had any impact on their genetic makeup.

How Can Blood Donation Affect Stem Cells?

As and when people age, their blood and other cells naturally develop mutations and some of them can also increase the risk of cancer. When anyone donates blood, his or her body compensates by producing new blood cells, which can influence the genetic diversity of stem cells in the bone marrow. The study also found that both groups had a similar number of mutations. For instance the frequent donors had 217 mutations, while the irregular donors had 212 mutations.

However, the nature of these mutations differed. In the frequent donors, 50% of the mutations were of a type not associated with a high risk of blood cancers, compared to only 30% in the irregular donors.

Further laboratory analysis showed that these specific mutations behaved differently from those linked to leukemia, a type of blood cancer. When human blood stem cells with these mutations were injected into mice, they were found to be highly effective at producing red blood cells, which is considered a positive outcome.

Dr. Hector Huerga Encabo, one of the study authors, emphasized that these mutations do not indicate an increased risk of leukemia. The findings suggest that regular blood donation may influence how stem cells evolve, but whether this translates into a lower cancer risk remains uncertain.

Read More: Who Can Donate Blood To Whom?

Limitations

One notable disadvantage is the "healthy-donor effect"—because blood donors are often healthier than the general population, their lower cancer risk could be unrelated to blood donation.

Dominique Bonnet, senior researcher and head of a stem-cell laboratory at the Francis Crick Institute, stressed the need for larger studies with female volunteers to confirm the findings.

Despite ongoing research into potential health benefits for donors, the primary goal of blood donation remains saving lives. NHS Blood and Transplant emphasized that while the study is interesting, further research is required to draw firm conclusions. The organization also noted that blood supplies are currently critically low and encouraged eligible individuals to donate.

Also Read: How Long After a Tattoo or Piercing Can I Donate Blood?

Sepsis that happened by a lick from a pet dog led to a woman losing all four of her limbs. Health and Me had previously reported that a Birmingham based woman, 56-year-old pharmacy worker Manjit Sangha caught sepsis from the lick of her pet dog. She spent her night in coma in the hospital and had to lose all her limbs. This happened because bacteria from dog's lick entered her body through a cut or a scratch. This led to sepsis, where the immune system's reaction to infection damaged the body's own tissues and organs.

This has brought a lot of attention on what sepsis is and what are the symptoms one must be aware of. As per the Sepsis Alliance, one must know about TIME to be aware of sepsis.

Unique Symptoms of Sepsis

TIME stands for temperature, infection, mental decline and extremely ill. If you notice these symptoms, rush to the hospital.

• T for Temperature: If you notice your body temperature rising or falling
• I for Infection: If you see signs or symptoms of any infection
• M for Mental Decline: If you feel confused, sleepy and difficult in rising
• E for Extremely Ill: If you feel severe pain, discomfort, shortness of breath

Unique Symptoms Of Sepsis: What To Know About Temperature

Your body temperature normally stays steady at about 98.6°F (37°C), with small changes based on activity, surroundings, and time of day. A reading of 100°F (37.7°C) or higher is considered a fever. During infection, the body often heats up to help fight germs. However, some people experience an unusual drop in temperature instead. Because of this, both a spike and a fall in temperature can be warning signs of sepsis.

Unique Symptoms of Sepsis: How To Know If You Have An Infection?

When an infection stays in one area, its symptoms usually match the site involved. A urinary tract infection may cause burning while urinating or frequent urges, pneumonia can bring cough and chest pain, and an infected cut may show redness or pus.

Read: Where You Get Your Rabies Shot Matters: Doctor Explains Why Rabies Vaccines Should Not Be Given In Buttocks

If the infection spreads through the body, broader symptoms like fever, tiredness, and body aches can appear. In some cases, an infection may not cause obvious symptoms at all. This is especially important to remember after surgery, medical procedures, skin injuries, or close contact with someone who is sick.

Unique Symptoms of Sepsis: What To Look Out For Mental Decline?

Sepsis can also alter how the brain functions. Some people, particularly older adults, may not develop the usual infection symptoms. Instead, they might suddenly become confused or show a sharp worsening of existing dementia. Marked drowsiness or unusual sleepiness is another common sign.

Unique Symptoms of Sepsis: Signs That You Are Extremely Ill

Many sepsis survivors recall feeling sicker than ever before. They describe overwhelming symptoms such as the most severe sore throat or abdominal pain they had experienced, along with a frightening sense that they might not survive.

Unique Symptoms Of Sepsis In Children

Unique Symptoms Of Sepsis In Adults

• High blood cell count
• Immature white blood cells in circulation
• Elevated plasma C-reactive protein
• Elevated procalctonin (PCT)
• Low blood pressue
• Low central venous or mixed venous oxygen saturation
• High cardiac index
• Low oxygen level
• Low urine output
• High creatinine in the blood
• Coagulation or clotting abnormalities
• Absent bowel sounds
• Low platelets in blood
• High bilirubin levels
• High lactate in blood
• Decreased capillary filling or mottling

Mounjaro, a popular weight loss drug that helped many lose weight, however, in this one case, a woman, who was on the same drug noticed something different. While she lost weight, she noticed that her breasts continued to grow. The 30-year-old Tianna Moon of East Anglia, a region in eastern England first realized something was not normal with her chest in 2024. This was when she started to use Mounjaro.

She was losing weight, but her breasts continued to grow. This is when Moon's doctor diagnosed her with a rare disease call gigantomastia, which causes breast tissue to grow rapidly and in excess.

Also Read: 15 States Sue Trump Administration Over Revised Vaccine Schedule

Woman Lost Weight On Mounjaro But Her Breasts Didn't Stop Growing: What Happened To Her?

Moon said that the doctors had thought that she had macromastia, a less severe, however, a similar condition. "But when I broke down medical history, the weight loss on Mounjaro and the increased growth and side effects, he was point-blank like, 'This is gigantomastia'," she said.

Moon also told that her breasts currently weight 39 lbs, which is approximately 20 per cent of her overall body weight.

Moon also said that while her large breasts are "normal" at this point in her life, she said the rare condition still comes with challenges.

"The side effects are having numb arms quite a lot and having quite severe indentations on my shoulders. I have some light scarring under my breasts where bras have rubbed and ripped the skin open."

She also said that laying on her back is something she cannot do for a long time, as it restricts the amount of airflow she can get in. She also said that when she goes out she tries to make her breasts look smaller than they are and strap them up. "I [still] get stares and double takes."

Also Read: Wegovy And Ozempic Will Cost Less In 2027, Novo Nordisk Slashes Weight Loss Drugs Prices By Half

Woman Lost Weight On Mounjaro But Her Breasts Didn't Stop Growing: What Is Gigantomastia?

As per Cleveland Clinic, it is a rare condition where your breasts become excessively large. It can also cause pain, infection, discomfort and issues with body image. It is also known as breast hypertrophy where one experiences rapid and disproportionate breast growth. The speed with which the breasts grow could vary depending on the person. It could take a few weeks to over several years. The tissue is almost never benign.

Gigantomastia is characterized by:

• Breasts that have an excess of at least 5 pounds of breast tissue.
• Extra breast tissue that equals more than 3% of your total body weight.

There are different types of gigastomastia:

• Juvenile gigantomastia: This type happens during puberty.
• Gestational gigantomastia: This is when gigantomastia occurs during pregnancy.
• Drug-induced gigantomastia (or medication-induced): This happens after taking certain drugs.
• Idiopathic gigantomastia: This is when the cause of gigantomastia is unknown or can't be determined. Idiopathic gigantomastia is the most common type.

Moon is now considering a breast reduction surgery. She has for now set up an account on OnlyFans. “I might as well try and reap the benefits of my medical condition rather than the negatives," she said.

The recent launch of the indigenous Td vaccine in India by Union Health Minister JP Nadda will boost immunity and reduce the risk of tetanus and diphtheria in children and adults, said health experts.

Union Health Minister JP Nadda formally launched the indigenously manufactured Td vaccine in Himachal Pradesh last week.

With the launch, the Tetanus Toxoid (TT) vaccine has been replaced with the Tetanus and adult diphtheria (Td) vaccine in India’s immunization program for all age groups, including pregnant women.

The move comes amid increasing numbers of cases of diphtheria amongst older age groups. Tetanus and diphtheria can lead to hospitalizations or even cause death. The Td vaccine will help to decrease diphtheria outbreaks.

“In keeping with global practice, India has shifted from TT, which covers for tetanus, to Td, which covers for both tetanus and diphtheria. This vaccine is indigenously manufactured and is expected to significantly reduce the risk of both these diseases in older children as well as adults,” Dr. Rajeev Jayadevan, Ex-President of IMA Cochin and Convener of the Research Cell, Kerala, told HealthandMe.

What Is The Td Vaccine?

The Td vaccine, indigenously manufactured at the Central Research Institute (CRI), Kasauli in Himachal Pradesh, is a combination of tetanus and diphtheria with a lower concentration of diphtheria antigen (d), and is recommended for older children and adults.

The use of Td, instead of TT, is recommended during pregnancy to protect against maternal and neonatal tetanus and diphtheria during prenatal care.

Vaccination during pregnancy also serves to boost immunity and increase the duration of protection in pregnant women who have not received the full set of recommended booster doses.

The Td is a safe vaccine, and 133 countries are currently using it.

The Health Ministry, in a statement, said that the Central Research Institute will supply 55 lakh doses to the UIP by April 2026, with production expected to scale up progressively in subsequent years to further strengthen the Universal Immunization Program in India.

“India’s indigenous Td vaccine rollout marks a significant milestone in strengthening the nation’s immunization program by enhancing self-reliance, affordability, and supply stability,” Dr. Neha Rastogi, Senior Consultant - Infectious Diseases, Fortis Gurugram, told HealthandMe.

“Locally produced vaccines reduce dependency on imports, ensuring uninterrupted protection for adolescents and adults against tetanus and diphtheria. This initiative supports wider coverage, faster distribution to remote regions, and improved public health preparedness,” she added.

Tetanus And Diphtheria: Disease burden In India

As per the National Health Profile 2022, India has reported 1,586 cases and 22 deaths due to diphtheria in 2020, and 3,677 cases and 47 deaths in 2021.

Around 10 Indian states report the majority (84 per cent) of the cases.

As of 21 June 2024, Orissa has also reported six deaths and 21 suspected diphtheria cases. There has been more than 90 percent coverage of diphtheria vaccination in birth cohorts since 2014, but gaps in booster dose coverage are widely prevalent.

Plugging of gaps in the routine immunization, coupled with inclusion of booster doses in the national data on diphtheria vaccination, is the need of the hour.

“Diphtheria is one of the most dangerous infectious diseases known to man; it spreads easily through the respiratory route. It can cause death due to the bacterial toxin affecting the heart (Myocarditis). It is vaccine-preventable, but the immunity fades over time,” Dr. Jayadevan said.

Therefore, the Td booster shots at ages 10 and 16 are essential to maintain protection. Similarly, pregnant women should receive two doses to protect both mother and child.

Given the recent outbreaks of diphtheria in India and elsewhere, this transition is a public health priority, the expert said.