A recent study suggests that people who donate blood regularly may have genetic changes in their blood that could in fact reduce the risk of developing cancer. It is conducted by the researchers at the Francis Crick Institute, and the study has now provided new insights into how and why blood cancers develop. The study is published in the journal Blood and was conducted by the scientists from Heidelberg and the German Red Cross blood donation center. There is yet a need for further research to confirm these findings.

What Did The Study Find?

The researchers examined the blood of two groups of healthy male donors in their 60s:

• One group had donated blood three times a year for 40 years.
• The other group had donated only about five times in total.

The goal was to analyze genetic mutations in their blood and assess whether frequent donation had any impact on their genetic makeup.

How Can Blood Donation Affect Stem Cells?

As and when people age, their blood and other cells naturally develop mutations and some of them can also increase the risk of cancer. When anyone donates blood, his or her body compensates by producing new blood cells, which can influence the genetic diversity of stem cells in the bone marrow. The study also found that both groups had a similar number of mutations. For instance the frequent donors had 217 mutations, while the irregular donors had 212 mutations.

However, the nature of these mutations differed. In the frequent donors, 50% of the mutations were of a type not associated with a high risk of blood cancers, compared to only 30% in the irregular donors.

Further laboratory analysis showed that these specific mutations behaved differently from those linked to leukemia, a type of blood cancer. When human blood stem cells with these mutations were injected into mice, they were found to be highly effective at producing red blood cells, which is considered a positive outcome.

Dr. Hector Huerga Encabo, one of the study authors, emphasized that these mutations do not indicate an increased risk of leukemia. The findings suggest that regular blood donation may influence how stem cells evolve, but whether this translates into a lower cancer risk remains uncertain.

Read More: Who Can Donate Blood To Whom?

Limitations

One notable disadvantage is the "healthy-donor effect"—because blood donors are often healthier than the general population, their lower cancer risk could be unrelated to blood donation.

Dominique Bonnet, senior researcher and head of a stem-cell laboratory at the Francis Crick Institute, stressed the need for larger studies with female volunteers to confirm the findings.

Despite ongoing research into potential health benefits for donors, the primary goal of blood donation remains saving lives. NHS Blood and Transplant emphasized that while the study is interesting, further research is required to draw firm conclusions. The organization also noted that blood supplies are currently critically low and encouraged eligible individuals to donate.

Also Read: How Long After a Tattoo or Piercing Can I Donate Blood?

When one thinks about cancer, the first thing that comes to mind is a mass of irregular cells growing wildly. But what is a tumour? It is much more than mere cancer cells surrounded by an extensive network of blood vessels, immune cells and various supporting cells. This is the tumour microenvironment.

One of the key residents of the tumour microenvironment is the cancer-associated fibroblast (CAF), which attracts increasing interest of cancer researchers due to the fact that such cells may affect tumour growth, metastasis and therapy response.

Normal fibroblasts have a supportive function in maintaining tissue integrity through the production of collagen and other structural components. However, when cancer arises, some fibroblasts located in or near the tumour acquire an additional function and become activated. Such activated fibroblasts are called CAFs.

How CAFs May Help Cancer Grow And Spread

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CAF involvement could be likened to that of a helper to the tumour. These cells are able to modify the stroma around the cancer cells and thereby facilitate growth and invasion into adjacent tissue. CAFs are also capable of releasing factors that facilitate angiogenesis as well as the behaviour of cancer cells. Evidence exists of a correlation between CAF involvement and tumour progression and metastasis in various types of cancer.

Perhaps more significantly, CAFs can affect the immune response of the body. The immune system in humans is able to detect and target foreign bodies including cancer cells. However, some forms of CAFs play a role in ensuring an immunosuppressed environment that makes it difficult for the immune cells to interact effectively with the tumour cells. This could explain the wide variation in immunotherapy response among patients and different tumour types.

The involvement of CAFs in treatment resistance is another issue that must be considered. Cancer-associated fibroblasts are known to remodel the extracellular matrix, an environment where cells are surrounded by proteins, and generate signals that help cancer cells resist stress induced by chemo and targeted therapy. CAFs therefore make treatment difficult for certain tumours.

Could CAFs Become A New Target For Cancer Treatment?

This field of study is especially important when considering that cancer treatments are becoming increasingly personalized. Today, oncologists take into consideration such features of cancer as genetic mutation, its stage and molecular profile. Tomorrow, taking into account tumor microenvironment can give them additional knowledge on how to treat a specific type of cancer.

But there is one major issue to be taken into consideration: CAFs are not one homogenous group of cells. There can be many types of CAFs that have very different functions, sometimes even opposing. Some of them contribute to tumor growth and some may hinder it. Thus, simply killing all fibroblasts will hardly help. Instead, there are studies on how to selectively target tumor promoting CAFs and how to reprogram them. Several such methods have already been tested clinically.

There is one important point that this research gives to patients: cancer is not just a mass of aberrant cells. Cancer is an ecosystem where cancer cells constantly interact with their environment.

Understanding this ecosystem might someday help oncologists tackle the mechanisms of tumor survival and resistance to therapy- and maybe make current cancer treatments more efficient.

By Dr Pritam Kalaskar, Director, Co-founder and Medical Oncologist- M|O|C Cancer Care, India

Obesity is often associated with obstructive sleep apnea or OSA. Extra body fat is a key risk factor. Still, it is a mistake to think OSA only happens when someone is heavy. Many people who have a normal weight may not connect their symptoms to a sleep issue.

They can go for years without a proper diagnosis. Research also makes it clear that OSA can show up in people who are not obese. Risk may be more than weight-dependent and include factors such as upper airway anatomy, age, sex, family history, and others.

How Airway Anatomy Can Increase The Risk

Weight is only part of the story. The jaw, the palate, the tongue, and the passages in the upper throat can affect what happens during sleep. The airway can narrow or collapse more easily for some people. A person may not be big in body size but can have a tight or smaller upper airway.

They might have a jaw that drops back. Other facial and skull features can also increase the likelihood of OSA. Your nose problems, smoking, drinking and other unwholesome activities on Sunday could also be factors.

Also read: ‘Feels Like I’m A Few Days From Death’: Olympic Sprinter Beth Dobbin Says She Is Bedbound 22 Hours A Day

Why Age And Menopause Matter

Age matters too. With time, muscle tone can change. The way the airway works can also shift. As a result, the upper airway may be more likely to collapse during sleep. For women, the risk may also shift around menopause and after it. This is why OSA should not be treated as a problem that only affects overweight men.

The symptoms should be taken seriously, not the scale. Signs such as loud snoring or snoring often, pauses seen in breathing, waking up suddenly and feeling short of breath, or choking during sleep can all call for assessment. Morning headaches can occur as well. Day-to-day problems like poor focus, irritability, and being very sleepy in the daytime are common clues. Some people do not report classic sleepiness. They may mainly notice restless sleep or ongoing tiredness during the day without a clear reason

How Doctors Assess Sleep Apnoea

A clinician should look at more than BMI. They can start with symptoms, a sleep history, neck size, what the upper airways look like, and any related health issues. If obstructive sleep apnoea is a real concern, a sleep test can show whether breathing problems happen during sleep.

The main point is this: a person can be slim and still have sleep apnoea. Deciding on testing should follow the full clinical picture, not body weight by itself. When this is remembered, some people may get help sooner, instead of having their tiredness written off as stress, bad sleep, or just normal fatigue.

A patient suffering from a rare tumour involving the sciatic nerve has made a good recovery following a successful robotic-assisted sciatic nerve schwannoma resection, marking an important milestone in advanced, minimally invasive surgical care.

Sciatic nerve schwannomas are uncommon, benign tumours that develop from the cells surrounding a nerve. Because the sciatic nerve is responsible for important motor and sensory functions of the lower limb, surgery in this region can be technically challenging. The key objective is to remove the tumour while preserving the functioning nerve fibres and minimizing the risk of neurological complications.

How Robotic Technology Can Aid Complex Surgery

The patient underwent robotic-assisted surgery under the care of a multidisciplinary surgical team. The use of robotic technology provided enhanced visualization and precise control of surgical instruments, allowing meticulous dissection around the affected nerve.

For the patient, the successful procedure meant not only removal of the tumour but also the prospect of returning to normal daily activities with preservation of neurological function.

Whenever the doctor operates on a tumour involving an important nerve, their priority is to achieve complete and safe tumour removal while protecting the nerve and its function. Robotic assistance can offer greater precision and visualization in carefully selected cases.

Following the procedure, the patient was closely monitored for neurological recovery and postoperative complications. The patient is doing well and recovering satisfactorily, providing an encouraging outcome following this complex surgical intervention.

How Minimally Invasive Techniques May Benefit Patients

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The case demonstrates how advances in surgical technology can translate into meaningful benefits for patients. Robotic-assisted surgery, when used in appropriately selected cases, can support surgeons in performing delicate procedures with enhanced precision while potentially reducing tissue trauma and facilitating recovery.

For patients diagnosed with nerve tumours, early evaluation and appropriate treatment planning are important. Symptoms can vary depending on the location and size of the tumour and may include pain, tingling, numbness, or weakness in the affected limb. Detailed imaging and neurological assessment help specialists determine the most appropriate treatment strategy.

The successful outcome reflects the importance of combining experienced surgical expertise, advanced technology, and patient-centred care. For this patient, the journey from diagnosis to successful tumour removal and recovery offers an encouraging example of what modern surgical care can achieve.

By Dr. S.K. Bala, Consultant Department of Surgical Oncology & Advanced Robotic Surgery, CMRI, CK Birla Hospitals, Kolkata