A recent study suggests that people who donate blood regularly may have genetic changes in their blood that could in fact reduce the risk of developing cancer. It is conducted by the researchers at the Francis Crick Institute, and the study has now provided new insights into how and why blood cancers develop. The study is published in the journal Blood and was conducted by the scientists from Heidelberg and the German Red Cross blood donation center. There is yet a need for further research to confirm these findings.

What Did The Study Find?

The researchers examined the blood of two groups of healthy male donors in their 60s:

• One group had donated blood three times a year for 40 years.
• The other group had donated only about five times in total.

The goal was to analyze genetic mutations in their blood and assess whether frequent donation had any impact on their genetic makeup.

How Can Blood Donation Affect Stem Cells?

As and when people age, their blood and other cells naturally develop mutations and some of them can also increase the risk of cancer. When anyone donates blood, his or her body compensates by producing new blood cells, which can influence the genetic diversity of stem cells in the bone marrow. The study also found that both groups had a similar number of mutations. For instance the frequent donors had 217 mutations, while the irregular donors had 212 mutations.

However, the nature of these mutations differed. In the frequent donors, 50% of the mutations were of a type not associated with a high risk of blood cancers, compared to only 30% in the irregular donors.

Further laboratory analysis showed that these specific mutations behaved differently from those linked to leukemia, a type of blood cancer. When human blood stem cells with these mutations were injected into mice, they were found to be highly effective at producing red blood cells, which is considered a positive outcome.

Dr. Hector Huerga Encabo, one of the study authors, emphasized that these mutations do not indicate an increased risk of leukemia. The findings suggest that regular blood donation may influence how stem cells evolve, but whether this translates into a lower cancer risk remains uncertain.

Read More: Who Can Donate Blood To Whom?

Limitations

One notable disadvantage is the "healthy-donor effect"—because blood donors are often healthier than the general population, their lower cancer risk could be unrelated to blood donation.

Dominique Bonnet, senior researcher and head of a stem-cell laboratory at the Francis Crick Institute, stressed the need for larger studies with female volunteers to confirm the findings.

Despite ongoing research into potential health benefits for donors, the primary goal of blood donation remains saving lives. NHS Blood and Transplant emphasized that while the study is interesting, further research is required to draw firm conclusions. The organization also noted that blood supplies are currently critically low and encouraged eligible individuals to donate.

Also Read: How Long After a Tattoo or Piercing Can I Donate Blood?

Bollywood actor Varun Dhawan recently opened up about the diagnosis of his 2-year-old daughter with Developmental Dysplasia of the Hip.

Varun, who welcomed his daughter Lara in 2024 along with his wife, Natasha Dalal, shared that the condition affected her ability to walk and run normally.

In a recent episode of Be A Man, Yaar!, Varun noted that the toddler’s condition was diagnosed when she was around one-and-a-half years old.

"My daughter was diagnosed with DDH, in which the hip slips out of the hip socket. Ek pair lamba chota hojaata hai jiski wajah se walk tedi hojaati hai (One leg becomes shorter than the other, which causes an uneven limp while walking). You can't walk or run properly," he said.

The Badrinath Ki Dulhania actor noted that Lara did not need surgery, but underwent a procedure that put her hip back.

“But she had to be in a spica cast. That means she had to be in a cast for 2.5 months. Which is extremely difficult. To put her under anesthesia, and then she woke up in a cast. Now the cast is out,” he said, adding that the baby is now in recovery.

The Border 2 actor said he chose to speak about Lara’s diagnosis to raise awareness among parents. He urged them to closely observe their children’s movements and consult a paediatrician if they notice anything unusual.

Also read: US FDA Approves Drug To Treat Rare Childhood Syndrome

What Is DDH? How Can It Be Diagnosed?

The UK NHS explains that Developmental dysplasia of the hip (DDH) is a condition where the "ball and socket" joint of the hip does not properly form in babies and young children.

The congenital multifactoral disease has about a 30 per cent increased risk if a family member is affected.

The hip joint typically connects the thigh bone (femur) to the pelvis. Its upper end, called the femoral head, is shaped like a ball and fits into a cup-like socket in the hip.

However, in children born with DDH, this socket is not deep enough to securely hold the femoral head, resulting in an unstable joint.

Also read: Child Deaths Fall In India Since 2000 But Progress Slows, Says UN Report

In more severe cases, the ball can slip out of the socket completely, leading to dislocation.

DDH may affect 1 or both hips, and is more common in:

• girls
• firstborn children
• families where there have been childhood hip problems
• babies born in the breech position

While some babies born with a dislocated hip will show no outward signs, common signs to look includes:

• Legs of different lengths
• Uneven skin folds on the thigh
• Less mobility or flexibility on one side
• Limping, toe walking, or a waddling gait

DDH: Is The Condition Treatable

Early detection is helpful and boosts treatment. When detected at birth, DDH can usually be corrected with the use of a harness or brace.

In cases where the hip is not dislocated at birth, the condition may not be noticed until the child begins walking. In such cases, treatment may be more complicated, with less predictable results.

Many women silently accept certain health issues as a normal part of life. However, many of these symptoms, such as painful menses and fatigue, can indicate underlying medical conditions that need attention. So, women shouldn’t neglect their health and seek timely help. Dr Payal Narang, Consultant Obstetrician & Gynaecologist, Motherhood Hospital, Pune, in an interview with Health and Me, spoke about the health problems that women often normalise, but that can become catastrophic in the long run.

Read more: Three Health Checks Every Woman Should Do Each Month, According To Experts

Women often juggle multiple responsibilities that include work, family, and household duties and neglect their own health. They are busy due to professional and personal life commitments and often fail to go for regular health check-ups. Moreover, they also experience menstrual problems and ignore symptoms such as painful periods, constant fatigue, heavy menstrual bleeding, and urinary leakage after childbirth. Women should consult a doctor instead of normalising these symptoms, which can delay diagnosis and treatment of important health issues. Paying attention to these signs and seeking medical advice can help women maintain better health and quality of life.

Concerning symptoms that women shouldn’t ignore at all

1. Painful menses that can interfere with the daily routine: Many women believe that severe menstrual pain is a natural part of having periods. Period pain is unavoidable. While mild cramps can be common, intense pain that interferes with daily activities may indicate conditions such as endometriosis, fibroids, or hormonal imbalance that need prompt treatment. Persistent pain should be evaluated by a doctor.
2. Fatigue: Feeling tired sometimes is normal, especially due to hectic schedules or traveling. However, constant fatigue that does not improve with rest may raise the chances of anemia, thyroid problems, nutritional deficiencies, or even stress. So, beware and pay attention to the symptoms.
3. Heavy menstrual bleeding: So, if bleeding lasts more than 7-8 days, requires frequent pad changes, or causes weakness and dizziness, it can be due to hormonal imbalance or fibroids. Heavy bleeding can also increase the risk of anemia if left untreated. So, address this problem with the help of an expert.
4. Urinary leakage after childbirth: Urinary leakage after childbirth is a concerning problem quietly accepted by women due to fear of being ridiculed, embarrassment, judgment, or shame. This can take a toll on the woman’s emotional well-being. She will avoid socializing due to the fear of leakage. It is commonly seen in a large number of women because of weakened pelvic floor muscles after childbirth. Various options, such as pelvic floor exercises, physiotherapy, and medical guidance, can help women to manage this condition and improve their quality of life.

Women, listening to the body, don’t just Google and try any remedies on your own. It is necessary to follow expert-recommended guidelines for tackling these problems.

Long considered a standard tool for assessing body weight, Body Mass Index (BMI) may not be as reliable as once believed. A new study shows that relying on BMI can incorrectly classify people as overweight or obese.

When a team of Italian researchers used the gold standard technique of dual-energy X-ray absorptiometry (DXA) to measure body fat in the general population, they found that the traditional WHO-approved BMI classification system misidentified a significant number of people as having overweight or obesity.

How Is The BMI Wrong?

A total of 1,351 adults of mixed gender aged between 18 and 98 years were checked for their body weight using the DXA system.

The results, published in the journal Nutrients, revealed that more than one-third (34 percent) of those with obesity defined by BMI had been misclassified and should be in the overweight category.

For those with an overweight BMI, DXA showed that more than half – 53 percent – had been misclassified – three quarters of those misclassified fall into the normal weight category, while the other quarter should have been classified as having obesity.

The DXA analysis found that the prevalence of overweight and obesity across the cohort was around 37 percent overall (23.4 percent overweight, and 13.2 percent obesity, compared to 26.2 percent and 14.1 percent with BMI).

“In the past few years, there has been a lot of criticism of the BMI system due to its inability to accurately capture body fat percentage or distribution, to correctly categorise weight status based on adiposity,” said Professor Marwan El Ghoch, of the Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena, Italy.

Also read: Your BMI Does Not Reflect Your Health: New Study Warns How It Misses A Key Health Aspect

Despite these concerns, BMI as a weight classification system continues to be used in the general population in primary healthcare (i.e., general practitioners) and non-clinical (i.e., policy and health insurance) settings, he added.

The researchers urged revising public health guidelines to consider combining direct body composition or their surrogate measures, such as skinfold measurement or body circumference, with the waist-to-height ratio, with BMI, while assessing weight status in the general population.

Waist-to-Height Ratio May Be More Accurate: The India Story

In January 2025, India revamped its obesity guidelines, and the new approach focused on abdominal obesity and comorbid diseases, rather than just BMI.

According to the redefining team, it was essential to move beyond BMI-only approaches to tackle the ever-growing number of people related to other major health risks. They stated that while BMI can be a screening tool, obesity must be defined by body fat.

“BMI should be used for screening purposes, but obesity should be confirmed ideally by a measure of body fat wherever feasible, or another measure such as waist circumference, WHR, or Waist-to-height ratio,” Dr. Naval Vikram, Professor of Medicine, at AIIMS, New Delhi, was quoted as saying to IANS at the time.

Also read: 41 million children aged 5-19 living with high BMI in India: Study

What Do The New Guidelines Say

It recognizes abdominal fat — closely linked to insulin resistance — as a key factor in the diagnosis. It integrates the presence of comorbidities — such as diabetes and cardiovascular disease — into the diagnostic process.

The revised guidelines also introduce a two-stage classification system, addressing both generalized and abdominal obesity.

Stage 1 Obesity: Increased adiposity (BMI > 23 kg/m²) without apparent effects on organ functions or routine daily activities.

Stage 2 Obesity: Advanced state of obesity with increased BMI more than 23 kg/2, and abdominal adiposity; excess Waist Circumference or Waist-to-Height Ratio.