A recent study suggests that people who donate blood regularly may have genetic changes in their blood that could in fact reduce the risk of developing cancer. It is conducted by the researchers at the Francis Crick Institute, and the study has now provided new insights into how and why blood cancers develop. The study is published in the journal Blood and was conducted by the scientists from Heidelberg and the German Red Cross blood donation center. There is yet a need for further research to confirm these findings.

What Did The Study Find?

The researchers examined the blood of two groups of healthy male donors in their 60s:

• One group had donated blood three times a year for 40 years.
• The other group had donated only about five times in total.

The goal was to analyze genetic mutations in their blood and assess whether frequent donation had any impact on their genetic makeup.

How Can Blood Donation Affect Stem Cells?

As and when people age, their blood and other cells naturally develop mutations and some of them can also increase the risk of cancer. When anyone donates blood, his or her body compensates by producing new blood cells, which can influence the genetic diversity of stem cells in the bone marrow. The study also found that both groups had a similar number of mutations. For instance the frequent donors had 217 mutations, while the irregular donors had 212 mutations.

However, the nature of these mutations differed. In the frequent donors, 50% of the mutations were of a type not associated with a high risk of blood cancers, compared to only 30% in the irregular donors.

Further laboratory analysis showed that these specific mutations behaved differently from those linked to leukemia, a type of blood cancer. When human blood stem cells with these mutations were injected into mice, they were found to be highly effective at producing red blood cells, which is considered a positive outcome.

Dr. Hector Huerga Encabo, one of the study authors, emphasized that these mutations do not indicate an increased risk of leukemia. The findings suggest that regular blood donation may influence how stem cells evolve, but whether this translates into a lower cancer risk remains uncertain.

Read More: Who Can Donate Blood To Whom?

Limitations

One notable disadvantage is the "healthy-donor effect"—because blood donors are often healthier than the general population, their lower cancer risk could be unrelated to blood donation.

Dominique Bonnet, senior researcher and head of a stem-cell laboratory at the Francis Crick Institute, stressed the need for larger studies with female volunteers to confirm the findings.

Despite ongoing research into potential health benefits for donors, the primary goal of blood donation remains saving lives. NHS Blood and Transplant emphasized that while the study is interesting, further research is required to draw firm conclusions. The organization also noted that blood supplies are currently critically low and encouraged eligible individuals to donate.

Also Read: How Long After a Tattoo or Piercing Can I Donate Blood?

A mammogram is routinely used to detect early signs of breast cancer, but the imaging test may also provide clues about a woman’s cardiovascular health.

Cardiovascular disease is a major cause of death among women. Yet, experts say heart disease in women can be overlooked because symptoms and risk factors may differ from the patterns traditionally associated with men.

Why Heart Disease Can Be Missed In Women

Prof Rob Galloway of University Hospitals Sussex NHS Foundation Trust, writing in the Daily Mail, highlighted the need to identify cardiovascular disease in women earlier.

Citing a 2021 The Lancet study, he noted that women with cardiovascular disease remain “understudied, under-recognized, underdiagnosed, and undertreated.”

Galloway said he regularly sees women, particularly those in their 60s, arriving in emergency care with heart attacks after earlier symptoms were attributed to less serious causes.

“If that had been recognized, she could have been admitted, and if needed, had a stent (a mesh tube) inserted to open the artery before it was blocked,” he wrote.

“The truth is doctors are not as good as we should be at recognizing heart disease in women, or understanding their risk,” he added.

Heart Attack Symptoms May Look Different In Women

Women may experience heart attacks differently, with symptoms such as breathlessness, nausea, fatigue, or back, neck and jaw pain. Galloway also highlighted female-specific risk factors, which include:

• Preeclampsia or high blood pressure during pregnancy
• Gestational diabetes
• Premature menopause
• Polycystic ovary syndrome (PCOS)

He said these factors are not always routinely included when assessing a woman’s long-term cardiovascular risk.

What Can A Mammogram Reveal About Heart Risk?

Prof Galloway suggested that routine breast screening could potentially offer another opportunity to identify cardiovascular risk.

When blood vessels are damaged, calcium can accumulate in their walls. Mammograms can sometimes detect calcium deposits in the arteries of the breast, known as breast arterial calcification (BAC).

BAC is different from calcium buildup in the coronary arteries, but its presence has been associated with a higher risk of cardiovascular events such as heart attack and stroke. Some radiologists may therefore flag the finding to the treating doctor.

Could AI Detect Heart Risk From Mammograms?

Prof Galloway also discussed the potential role of artificial intelligence in identifying and measuring breast arterial calcification.

A European Heart Journal study used AI to assess mammograms from over 123,500 US women. Compared with no calcification, mild breast arterial calcification was linked to a 30% higher cardiovascular event risk, moderate to 75–80% higher risk, and severe to roughly three times higher risk.

The association persisted even after researchers accounted for established cardiovascular risk factors such as obesity and smoking.

Could Mammograms Become A Cardiovascular Screening Tool?

Prof Galloway said that the potential advantage is that the mammogram has already been performed for breast screening. If arterial calcification is identified, that information could potentially be included with the screening result and prompt a broader cardiovascular risk assessment.

Depending on the woman's overall risk, doctors could then consider measures such as more intensive management of blood pressure or cholesterol.

A coronary artery calcium scan is another way to assess calcium buildup in the arteries supplying the heart. It uses a CT scan to detect and measure coronary artery calcium and can help inform cardiovascular risk assessment in appropriate patients.

There are many patients with CKD and CKD touches more than just the kidneys. CKD also influences parts of the body and as kidney function falls changes in the body can affect the brain. This may raise the chance of memory problems trouble concentrating and other types of impairment. For people living with CKD, those whose disease is advanced protecting cognitive health can become an important part of overall care.

CKD can arise from causes with diabetes as a leading one. In some groups diabetes accounts for than half of CKD cases. When diabetes meets CKD, the risk of vascular disease rises. This disease builds fatty deposits inside blood vessels. If those vessels feed the brain blood flow can drop. Reduced brain blood flow can lead to problems and raise the risk of dementia.

Waste Build-Up And Electrolyte Changes May Affect Thinking

Another important factor is the build‑up of waste in the blood. Healthy kidneys waste and excess substances. When CKD lowers kidney function these substances linger. The lingering waste can disturb brain function. Symptoms may include trouble paying attention, slower thinking, confusion or memory problems.

Electrolyte disturbances can also play a role especially when CKD changes the balance of minerals in the body.

Hyponatremia or abnormally low levels of sodium in the blood is relatively common in people with CKD. It can disturb brain function.

Depending on severity and how fast it appears hyponatremia can cause confusion, difficulty concentrating, drowsiness and in cases more serious neurological symptoms.

Also read: Diabetes Linked To 55% Risk Of Kidney Disease, Heart Failure Or Death Within 10 Years: Study

How Dialysis And Treatment History Can Influence Cognitive Health

Treatment‑related factors may also be relevant for some patients.

In the past dialysis patients who received aluminium‑containing medicines, such as some antacids or phosphate‑binding preparations faced a risk of aluminium build‑up. High levels of aluminium were linked to problems, including cognitive impairment. Today dialysis practices and medicines have cut this risk dramatically so aluminium is now an issue rather than a common cause of cognitive problems in dialysis patients.

Why Early Recognition Of Cognitive Changes Matters

As CKD moves forward into advanced stages the risk of cognitive impairment grows. Many factors can act together: disease, metabolic and electrolyte changes, anaemia, inflammation, heart complications and the build‑up of toxins that healthy kidneys would normally flush away.

Not every person with CKD will develop dementia. Cognitive changes should not be brushed off as normal ageing. New problems, with memory, concentration orientation or daily tasks need to be talked about with a doctor.

Early recognition is important because some of these factors can be treated or reversed.

Keeping diabetes and blood pressure under control managing heart risk factors correcting electrolyte imbalances and getting kidney care all help protect both kidney and brain health.

Plastics are everywhere today. It is woven into our clothes, tucked into children's toys, used in food containers, and found in almost every household products. A new analysis has raised concerns about the chemicals used to make these products and the health hazards due to constant exposure.

According to an investigation reported by CNN, nearly 93% of known plastic chemicals used in everyday products were classified as posing a high risk to human health. The analysis looked at plastics used in food-contact materials, toys, clothing and textiles, household products, and hygiene and medical products.

Also Read: Delhi HC Backs Reproductive Autonomy For Women With Disabilities: When Is Hysterectomy Medically Necessary?

The findings highlight how widespread exposure to hazardous chemicals can affect our health and how much remains unknown about their long-term effects.

Exposure To Plastic Chemicals

A researcher at Environmental Justice Foundation, Naima Fenderl’s Poison Plastics: How Chemicals in Everyday Plastics are Harming Your Health released recently and revealed astounding facts about plastic chemicals.

She said, “We looked at what these plastic chemicals can do to the body along with exposure levels to calculate overall health risk.” The analysis found that:

• Nearly 92% of chemicals in food-related plastics were considered high risk.
• Almost 89% of children's toys contained high-risk plastics.
• Around 93% of textiles and clothing involved dangerous chemicals.
• More than 92% of common household products contained high-risk chemicals.
• Nearly 93% of hygiene and medical plastics contained potentially dangerous chemicals.

The chemicals are not necessarily the plastic itself. Many are additives that are used to make plastics flexible, durable, heat-resistant, or less likely to catch fire.

Also read: Botox And Fillers: UK Watchdog Says Clinics Should Check Mental Health Before Injecting

Health Problems Caused By Plastic Chemicals

Some plastic chemicals have been linked to cancer, genetic changes and problems affecting the hormonal, reproductive and organ systems. Among the chemicals of concern are bisphenols, phthalates, and PFAS, which can be used in different plastic products.

Some of these chemicals can interfere with the body's endocrine system, which controls hormones involved in metabolism, reproduction, growth, and development.

The concern is important for children and during pregnancy because hormonal systems and organ development may be more vulnerable to certain chemical exposures.

The report also highlighted the challenge of lack of sufficient data to certainly assess health risks posed by these plastic chemicals. Almost 80% of the 3,552 chemicals in plastics people often use everyday lacked sufficient data to understand health risks.

“We simply do not have a clue what harm those chemicals might be causing us and our kids,” Dr. Philip Landrigan, director of the Global Observatory on Planetary Health and the Program for Global Public Health and the Common Good at Boston College told CNN.

He added, “We don’t even know the names or composition of a lot of the chemicals that are in consumer products — the chemical industry presumably has that information, but it’s not publicly available.”

Microplastics Are Part Of The Problem Too

Chemical exposure is only one part of the plastic problem. Tiny plastic particles, known as microplastics, and even smaller nanoplastics, can also enter our bodies through food and water.

University of Columbia released an analysis of plastic bottled water based on a laser-based highly sensitive imaging technique. It found an average of around 240,000 plastic particles per litre, with most nanoplastics.

These particles can come from the bottle, the cap, manufacturing, and handling. Opening and closing the bottle repeatedly can also create friction between the cap and bottle neck, releasing tiny plastic fragments.

Larger particles are generally expected to pass through the digestive system. But nanoplastics are small enough to cross biological barriers.

Research has found that plastic particles can reach the circulatory system and other tissues, but scientists still do not know exactly which particles cross these barriers most easily, how much accumulates in the body or what level of exposure causes harm.

What Is The Solution?

Quitting using plastic entirely is not practical for most people. Instead, reducing avoidable exposure could be a sensible approach.

Avoid heating food in plastic containers, particularly when the container is not designed for high temperatures. Using glass or stainless steel for hot food and drinks can also reduce reliance on plastic food-contact materials.

Filtration or boiling of drinking water may help reduce some microplastics. But doctors believe that heat may only alter some plastic particles, not destroy them completely.