For those who have not experienced a migraine, perhaps it would seem just another headache. But for someone like me who has suffered through migraines that will last over a week even with medication, I can definitely tell you that it's much more. The ache is not confined to the head; it's the whole experience. Nausea, sensitivity to light, and throbs so bad it makes simple tasks unbearable. It also comes with an emotional burden—the loneliness and frustration are pretty unbearable. Through the years, realizing how hormones are also implicated in triggering and exacerbating my migraines has helped change the game in my dealing with these episodes.

What are Hormonal Migraines?

Hormonal migraines are caused by fluctuations in estrogen and progesterone, the two main female hormones. These hormones are essential for the reproductive system, regulating menstrual cycles and pregnancy. They also have an effect on brain chemicals, such as serotonin and dopamine, which affect mood and pain perception. When hormone levels fluctuate, such as during menstruation, pregnancy, or menopause, they can destabilize the pathways in the brain, causing migraines.

According to Dr. Shivananda Pai, Consultant Neurology, migraines are more than a neurological disorder. "Migraines represent a complex interplay of genetic, environmental, and hormonal factors. In women, hormonal fluctuations are a critical trigger that amplifies sensitivity to pain," he explains. Hormonal headaches are particularly challenging because they are influenced by multiple life stages, from puberty to post-menopause. Common causes include:

• Menstrual periods: Estrogen levels significantly drop just before menstruation often triggers a migraine.
• Pregnancy: Hormones can act to relieve symptoms or aggravate them during different times of pregnancy.
• Menopause: The hormonal fluctuation during menopause can intensify a migraine, while some women tend to find relief.
• Hormonal therapies: Birth control and HRT tend to level off hormone balances in some individuals but will exacerbate a migraine in others.

Complex Role of Hormones in Women’s Neurological Health

Estrogen and Neurological Health

Estrogen, often called the "hormone of femininity", does more than regulate reproductive functions. It is a powerful influencer of brain health. Estrogen modulates the activity of neurotransmitters like serotonin, which regulates mood and pain perception, and dopamine, associated with reward and pleasure.

During stages of hormonal stability, like in pregnancy's latter months, women may have fewer migraines because of the steady elevation of estrogen. However, a sudden downfall in estrogen destabilizes these chemicals in the brain, sending a heightened sensitivity for migraine triggers.

Menstrual Migraines

The most common form of hormonal migraines is menstrual migraines, which occur in response to the steep decline in estrogen levels just before menstruation. These are typically more intense and less responsive to standard treatment. The timing of these migraines provides clear evidence of the role hormones play in neurological health.

Pregnancy and Hormonal Shifts

Pregnancy is a rollercoaster of hormones. Although many women experience relief from migraines as a result of the constantly elevated levels of estrogen, some women, particularly in the first trimester, worsen. This individual variability is a characteristic of hormonal migraine triggers.

Hormonal Therapies and Management of Migraine

Hormonal treatments, such as oral contraceptives and HRT, have had mixed reviews regarding their use in managing migraine. Some women fare better with the stabilization the treatment provides, whereas others suffer worsening symptoms. This will depend on the nature and dose of the hormones used.

Post-Menopause: Migraine Remission or Continued Struggles?

For most women, menopause brings relief from their migraines. The decline in frequency and severity often accompanies stability in hormone levels. Even so, the susceptibility remains with some towards other forms of triggers including stress and sleep deprivation, not to forget diet-related factors and continues the saga of migraines well after the menopausal stages.

Effect on Neurological Health Due to Hormonal Changes

The relationship of hormones to neurological health goes beyond migraines. Hormonal changes have profound effects on a woman's brain in general.

Mood Disorders: Estrogen helps stabilize mood by regulating serotonin. Its decline at menopause increases the risk of mood swings and depression.

Neurodegenerative Diseases: Estrogen is neuroprotective, stimulating the growth and repair of brain cells. Its absence in post-menopausal women has been associated with an increased risk of Alzheimer's disease and cognitive decline.

Multiple Sclerosis (MS): Hormonal cycles may affect the course of MS, a disease that occurs more frequently in women than in men. Estrogen's anti-inflammatory effects provide transient protection during pregnancy, reducing relapse rates in women with MS.

"The intricate interplay between hormones and neurological health underscores the need for gender-specific treatment approaches," says Dr. Pai.

Managing Hormonal Migraines: Practical Strategies

While hormonal changes are inevitable, several strategies can help manage migraines effectively:

1. Tracking Your Cycle

Understanding your menstrual cycle can help identify patterns and predict when migraines might occur. This knowledge allows for preventive measures, such as scheduling medications or adjusting lifestyle habits.

2. Consulting Specialists

Working with a neurologist or gynecologist can help develop a personalized treatment plan. Options might include hormonal therapies, triptans, or preventive medications tailored to your specific needs.

3. Adopting a Healthy Lifestyle

A well-balanced diet, regular exercise, and stress management are all integral parts of managing migraines. For instance, magnesium-rich foods and hydration can help reduce the frequency and severity of attacks.

4. Exploring Preventive Therapies

For people with severe or frequent migraines, preventive medications, such as beta-blockers or CGRP inhibitors, may be prescribed. These medications stabilize brain activity and therefore reduce the chances of migraine during hormonal fluctuations.

5. Mind-Body Techniques

Techniques like yoga, meditation, and biofeedback can enhance wellness and reduce the debilitating effects of stress-one of the most common migraine triggers.

Research that was once in its embryonic stage continues to shed more light on the role of hormones in migraines and other neurological conditions. Further breakthroughs in genetic testing might enable doctors to predict, at least in a way, how an individual would react to hormonal therapies. The importance of gender-specific approaches is gradually being realized, which involves differentiating between the plight of women with migraines from others.

As Dr. Pai puts it, "Empowering women with knowledge about the hormonal underpinnings of migraines can lead to better, more personalized care. With the right strategies, migraines can be effectively managed, allowing women to lead fuller, healthier lives.

Migraines are not headaches; they are a complex neurological condition that deeply impacts the lives of millions of women. Understanding the role of hormones in triggering and exacerbating migraines is a vital step toward better management and relief.

Awareness, proactive care, and advances in medical research can help women regain their lives from the grip of hormonal migraines. Whether tracking cycles, adopting healthier habits, or seeking tailored medical care, every step taken toward understanding and managing migraines is a step toward empowerment.

Dr Shivananda Pai is a Consultant Neurology at KMC Hospital Dr B R Ambedkar Circle in Mangalore, India.

Brandes JL. The Influence of Estrogen on Migraine: A Systematic Review. JAMA. 2006;295(15):1824–1830. doi:10.1001/jama.295.15.1824

Sacco S, Ricci S, Degan D, Carolei A. Migraine in women: the role of hormones and their impact on vascular diseases. J Headache Pain. 2012 Apr;13(3):177-89. doi: 10.1007/s10194-012-0424-y. Epub 2012 Feb 26. PMID: 22367631; PMCID: PMC3311830.

For most working professionals, Parkinson’s disease still feels like something that happens much later in life. It’s not something people in their 30s or even early 40s actively think about. But this scenario is changed with early onset Parkinson’s disease (EOPD). This can affect people between the ages of 21 and 50.

The problem is not just the condition itself, but how it subtly integrates into everyday life. Despite this shift, early symptoms in working professionals often go unnoticed or are misattributed to stress, fatigue, or demanding work schedules.

What Is Early-Onset Parkinson’s Disease?

Parkinson’s disease is a neurological condition that affects movement and coordination due to a reduction in dopamine-producing cells in the brain. When it occurs between the ages of 21 and 50, it is referred to as early-onset Parkinson’s disease (EOPD). In younger individuals, the condition often develops slowly and remains mild in the beginning, which makes it harder to recognize. The exact cause may involve a mix of genetic factors and environmental triggers.

Symptoms can include both movement and non-movement changes. Movement-related symptoms may involve muscle stiffness, slowed movements, mild balance issues, tremors at rest, while non-movement symptoms such as constipation, unexplained pain, sexual dysfunction, and sleep disturbances like insomnia may appear early.

In day-to-day life, these changes often show up subtly as slight hand shaking at rest, taking longer to complete routine tasks, stiffness in the neck or shoulders, a softer or less expressive voice, and disturbed sleep patterns, signs that are easy to overlook or dismiss.

What are the symptoms that working professionals may miss?

1. Symptoms Overlap With Lifestyle Issues: In fast-paced work environments, fatigue, body aches, and sleep disturbances are common. Early Parkinson’s symptoms, such as stiffness, low energy, or poor sleep, are often dismissed as burnout or long working hours.

2. Lack of Awareness in Younger Age Groups: Both patients and even healthcare providers may not immediately suspect Parkinson’s in someone in their 30s or 40s. This leads to delays in seeking medical advice and diagnosis.

3. Absence of Classic Tremors Initially: Tremors are widely recognized as a hallmark of Parkinson’s, but they may not appear in the early stages. Instead, symptoms like reduced arm swing while walking or slight slowness in movements may be present but overlooked.

4. Attribution to Mental Health or Stress: Subtle changes such as anxiety, low mood, or difficulty concentrating can be early indicators. However, these are often attributed to workplace stress rather than a neurological cause.

5. Gradual Onset of Symptoms: Parkinson’s develops slowly. Changes in handwriting, posture, or speech may happen over time, making them difficult to notice unless specifically looked for.

How Can Parkinson’s Be Diagnosed and Managed?

Because early signs are often overlooked, the condition is often recognized only when it begins to affect daily life. Diagnosis typically involves a detailed assessment along with blood tests and imaging, such as MRI, and in some cases, specialized scans like a dopamine transporter (DAT) scan may also be advised to support the diagnosis.

Management focuses on improving quality of life through physical therapy to support movement and balance, occupational therapy to make daily activities easier, and speech therapy to address communication changes. In more severe cases, deep brain stimulation (DBS) surgery may be considered to help manage symptoms more effectively.

Parkinson’s at a younger age is often easy to overlook, especially when early signs blend into everyday stress and fatigue. Paying closer attention to overall well-being can help. Staying physically active, following a balanced diet, maintaining good sleep habits, and managing stress levels all play an important role in supporting brain health. Being mindful of small but persistent changes and not brushing them off as routine can go a long way in ensuring timely attention and better long-term.

World Parkinson’s Day is observed every year on April 11 to raise awareness about the progressive, neurodegenerative movement disorder caused by the loss of dopamine-producing brain cells.

People suffering from Parkinson’s face problems in motor movement, tremors, stiffness, and impaired balance. As symptoms progress, people may have difficulty walking, talking, or completing other simple tasks.

The condition primarily affects people over 60, but is now increasingly being seen in young adults. Apart from motor loss, the disease also causes cognitive decline, depression, anxiety, and swallowing problems.

World Parkinson's Day 2026: Origin

Parkinson's Day is observed on the day that marks the birthday of James Parkinson (born in 1755). The London-based doctor was the first to describe Parkinson as a medical condition in 1817, in his famous ‘Essay on the Shaking Palsy’. In 1997, the day was officially established by the European Parkinson’s Disease Association.

World Parkinson's Day 2026: Theme

The theme of World Parkinson's Day 2026 is "Bridge the Care Gap." It reflects a critical challenge that persists despite advances in medical research: many people living with Parkinson's still lack consistent access to specialist care, affordable treatment, and integrated support systems.

The day also aims to raise awareness about neurodegenerative diseases by educating the public about Parkinson's symptoms, causes, and available care.

Global Burden of Parkinson’s

Parkinson's disease affected 11.9 million people in 2021 and will affect 25.2 million people globally by 2050, representing an alarming 112 per cent rise.

According to a 2025 study released by The BMJ, this rise is mainly due to population aging and hence ranks as one of the most rapidly growing neurological disorders based on prevalence and disability. This alarming increase necessitates immediate global health interventions, research innovation, and policy reform to counteract its effects on people and health systems globally.

In addition, lifestyle differences, genetic susceptibility, and environmental exposures can also lead to regional variation in prevalence.

What Happens To Your Brain In Parkinson's Disease?

Parkinson's Disease affects various brain regions, but the primary symptoms arise from the degeneration of neurons in the substantia nigra, a region near the brain's base. This area is crucial for producing dopamine, a chemical messenger essential for smooth and purposeful movement. Research indicates that by the time Parkinson's symptoms become evident, patients have typically lost 60 to 80% or more of these dopamine-producing neurons.

Additionally, individuals with Parkinson’s disease experience a reduction in nerve endings that produce norepinephrine, a neurotransmitter responsible for regulating many involuntary bodily functions, such as heart rate and blood pressure. This loss may account for some non-movement-related symptoms of Parkinson’s, such as fatigue and fluctuations in blood pressure.

How to Prevent Parkinson's

Though there is no cure for Parkinson's disease yet, studies indicate that some lifestyle elements have the potential to shape its incidence and progression.

• Physical Activity – Engaging in regular exercise has been linked to a reduced risk of Parkinson’s, potentially due to its neuroprotective effects.
• Diet and Nutrition – A balanced diet rich in antioxidants, omega-3 fatty acids, and plant-based nutrients may support brain health.
• Environmental Factors – Exposure to pesticides, heavy metals, and air pollution has been associated with an increased risk, suggesting a need for improved public health measures.

Indian Actress Dipika Kakkar, battling liver cancer, underwent another surgery last month for a 1.3 cm cyst that reappeared.

Best known for her role as Simar Bhardwaj in the hit TV show Sasural Simar Ka, Dipika underwent a major tumour-removal surgery in June 2025. She also undertook chemotherapy

In her latest vlog, Dipika shared that the unexpected recurrence has left her feeling anxious and overwhelmed as doctors evaluate the next course of treatment.

"The recurrence that happened with the 1.3 cm cyst has shaken me. I am a little scared now that it shouldn't happen again. I have started dieting, but I feel anxious," she said.

HealthandMe spoke to health experts to understand why cysts recur in liver cancer patients and how it's important to keep monitoring them.

According to health experts, a biannual liver scan is imperative, and it can detect signs of cysts.

“Simple cysts less than 2-3 Cm can be observed with repeat scans every 6 months to 1 year. Suspicious or malignant cysts need surgical resection and oncological treatment based on the histopathology and patient condition,” Dr Manjunath NML, Sr Consultant, Surgical Oncology and Robotic Surgeon, HCG Cancer Hospital, K R Road, Bengaluru.

What Are Liver Cysts? How It's Linked To Cancer

Liver cysts are like bags that are filled with fluid. They are usually not cancer. Most people who have liver cysts do not get cancer.

However, just because one has a cyst, it does not mean it's cancer.

“Cysts in the liver are typically harmless and unrelated to liver cancer. However, unusual types of cysts may suggest malignant changes that need further examination, particularly among risk groups,” Dr. Govind Nandakumar, Consultant – Gastrointestinal Surgery, Manipal Hospitals Hebbal, told HealthandMe.

The experts noted that cases of recurring cysts related to liver cancer are uncommon. But they occur because of

• the presence of cancerous cells,
• regrowth of the organ,
• chronic conditions like cirrhosis.

Also read: 1 In 4 Diabetic Patients in India Suffer from Liver Fibrosis, Finds Lancet Study

Are There Early Warning Signs Patients Should Watch For?

Many liver cysts do not cause any problems in the early stages. That is why regular check-ups with a doctor are important. If a cyst grows or becomes problematic, symptoms may begin to appear. These can include

• abdominal pain,
• bloating,
• nausea,
• weight loss,
• yellowing of the skin,
• fatigue.

Is Recurrent Cysts A Cause Of Worry?

Recurrent cysts can be effectively managed and treated over time. The recurrence does not necessarily imply the progression of the condition itself; however, more tests may be required to determine whether cysts are malignant or benign.

“Cysts with thick walls, septations inside, and solid components in them are more likely to be cancerous. If the cysts are large, they cause symptoms like pain, distension, and obstruction of the bowel or biliary tract,” Dr Manjunath said.

The experts explained that diagnosis can be achieved by scans like ultrasonography, Computerized Tomography CT or Magnetic Resonance Imaging (MRI). Suspicious cysts must be checked via biopsy to confirm malignancy.

While suspicious or malignant cysts require surgical resection and oncological treatment, symptomatic cysts, even if benign, may also require removal.

However, if a liver cyst is detected without suspicious features and is asymptomatic, it usually does not require any intervention, Dr. Manjunath noted.