For those who have not experienced a migraine, perhaps it would seem just another headache. But for someone like me who has suffered through migraines that will last over a week even with medication, I can definitely tell you that it's much more. The ache is not confined to the head; it's the whole experience. Nausea, sensitivity to light, and throbs so bad it makes simple tasks unbearable. It also comes with an emotional burden—the loneliness and frustration are pretty unbearable. Through the years, realizing how hormones are also implicated in triggering and exacerbating my migraines has helped change the game in my dealing with these episodes.

What are Hormonal Migraines?

Hormonal migraines are caused by fluctuations in estrogen and progesterone, the two main female hormones. These hormones are essential for the reproductive system, regulating menstrual cycles and pregnancy. They also have an effect on brain chemicals, such as serotonin and dopamine, which affect mood and pain perception. When hormone levels fluctuate, such as during menstruation, pregnancy, or menopause, they can destabilize the pathways in the brain, causing migraines.

According to Dr. Shivananda Pai, Consultant Neurology, migraines are more than a neurological disorder. "Migraines represent a complex interplay of genetic, environmental, and hormonal factors. In women, hormonal fluctuations are a critical trigger that amplifies sensitivity to pain," he explains. Hormonal headaches are particularly challenging because they are influenced by multiple life stages, from puberty to post-menopause. Common causes include:

• Menstrual periods: Estrogen levels significantly drop just before menstruation often triggers a migraine.
• Pregnancy: Hormones can act to relieve symptoms or aggravate them during different times of pregnancy.
• Menopause: The hormonal fluctuation during menopause can intensify a migraine, while some women tend to find relief.
• Hormonal therapies: Birth control and HRT tend to level off hormone balances in some individuals but will exacerbate a migraine in others.

Complex Role of Hormones in Women’s Neurological Health

Estrogen and Neurological Health

Estrogen, often called the "hormone of femininity", does more than regulate reproductive functions. It is a powerful influencer of brain health. Estrogen modulates the activity of neurotransmitters like serotonin, which regulates mood and pain perception, and dopamine, associated with reward and pleasure.

During stages of hormonal stability, like in pregnancy's latter months, women may have fewer migraines because of the steady elevation of estrogen. However, a sudden downfall in estrogen destabilizes these chemicals in the brain, sending a heightened sensitivity for migraine triggers.

Menstrual Migraines

The most common form of hormonal migraines is menstrual migraines, which occur in response to the steep decline in estrogen levels just before menstruation. These are typically more intense and less responsive to standard treatment. The timing of these migraines provides clear evidence of the role hormones play in neurological health.

Pregnancy and Hormonal Shifts

Pregnancy is a rollercoaster of hormones. Although many women experience relief from migraines as a result of the constantly elevated levels of estrogen, some women, particularly in the first trimester, worsen. This individual variability is a characteristic of hormonal migraine triggers.

Hormonal Therapies and Management of Migraine

Hormonal treatments, such as oral contraceptives and HRT, have had mixed reviews regarding their use in managing migraine. Some women fare better with the stabilization the treatment provides, whereas others suffer worsening symptoms. This will depend on the nature and dose of the hormones used.

Post-Menopause: Migraine Remission or Continued Struggles?

For most women, menopause brings relief from their migraines. The decline in frequency and severity often accompanies stability in hormone levels. Even so, the susceptibility remains with some towards other forms of triggers including stress and sleep deprivation, not to forget diet-related factors and continues the saga of migraines well after the menopausal stages.

Effect on Neurological Health Due to Hormonal Changes

The relationship of hormones to neurological health goes beyond migraines. Hormonal changes have profound effects on a woman's brain in general.

Mood Disorders: Estrogen helps stabilize mood by regulating serotonin. Its decline at menopause increases the risk of mood swings and depression.

Neurodegenerative Diseases: Estrogen is neuroprotective, stimulating the growth and repair of brain cells. Its absence in post-menopausal women has been associated with an increased risk of Alzheimer's disease and cognitive decline.

Multiple Sclerosis (MS): Hormonal cycles may affect the course of MS, a disease that occurs more frequently in women than in men. Estrogen's anti-inflammatory effects provide transient protection during pregnancy, reducing relapse rates in women with MS.

"The intricate interplay between hormones and neurological health underscores the need for gender-specific treatment approaches," says Dr. Pai.

Managing Hormonal Migraines: Practical Strategies

While hormonal changes are inevitable, several strategies can help manage migraines effectively:

1. Tracking Your Cycle

Understanding your menstrual cycle can help identify patterns and predict when migraines might occur. This knowledge allows for preventive measures, such as scheduling medications or adjusting lifestyle habits.

2. Consulting Specialists

Working with a neurologist or gynecologist can help develop a personalized treatment plan. Options might include hormonal therapies, triptans, or preventive medications tailored to your specific needs.

3. Adopting a Healthy Lifestyle

A well-balanced diet, regular exercise, and stress management are all integral parts of managing migraines. For instance, magnesium-rich foods and hydration can help reduce the frequency and severity of attacks.

4. Exploring Preventive Therapies

For people with severe or frequent migraines, preventive medications, such as beta-blockers or CGRP inhibitors, may be prescribed. These medications stabilize brain activity and therefore reduce the chances of migraine during hormonal fluctuations.

5. Mind-Body Techniques

Techniques like yoga, meditation, and biofeedback can enhance wellness and reduce the debilitating effects of stress-one of the most common migraine triggers.

Research that was once in its embryonic stage continues to shed more light on the role of hormones in migraines and other neurological conditions. Further breakthroughs in genetic testing might enable doctors to predict, at least in a way, how an individual would react to hormonal therapies. The importance of gender-specific approaches is gradually being realized, which involves differentiating between the plight of women with migraines from others.

As Dr. Pai puts it, "Empowering women with knowledge about the hormonal underpinnings of migraines can lead to better, more personalized care. With the right strategies, migraines can be effectively managed, allowing women to lead fuller, healthier lives.

Migraines are not headaches; they are a complex neurological condition that deeply impacts the lives of millions of women. Understanding the role of hormones in triggering and exacerbating migraines is a vital step toward better management and relief.

Awareness, proactive care, and advances in medical research can help women regain their lives from the grip of hormonal migraines. Whether tracking cycles, adopting healthier habits, or seeking tailored medical care, every step taken toward understanding and managing migraines is a step toward empowerment.

Dr Shivananda Pai is a Consultant Neurology at KMC Hospital Dr B R Ambedkar Circle in Mangalore, India.

Brandes JL. The Influence of Estrogen on Migraine: A Systematic Review. JAMA. 2006;295(15):1824–1830. doi:10.1001/jama.295.15.1824

Sacco S, Ricci S, Degan D, Carolei A. Migraine in women: the role of hormones and their impact on vascular diseases. J Headache Pain. 2012 Apr;13(3):177-89. doi: 10.1007/s10194-012-0424-y. Epub 2012 Feb 26. PMID: 22367631; PMCID: PMC3311830.

As men step into their 50s and beyond, prostate health becomes an essential part of overall wellbeing. The gland naturally undergoes changes with age, many of which are not cancerous but can still cause discomfort, disrupt daily routines, and affect long-term health. Awareness, early screening, and preventive habits play a crucial role in staying ahead of potential problems.

Why the Prostate Changes With Age

One of the most common age-related concerns is benign prostate hyperplasia (BPH), a non-cancerous enlargement of the prostate. This happens due to hormonal shifts that cause the gland to grow slowly over time.

“Most men assume urinary symptoms are just a normal part of aging, but that mindset often delays treatment,” says Dr. Vineet Malhotra, Director and Founder, VNA Hospital. “BPH itself is not dangerous, but if ignored, it can seriously affect quality of life and even lead to complications.”

A larger prostate can press against the urethra, causing symptoms such as:

• Frequent urination
• Weak or interrupted urine flow
• Difficulty starting to urinate
• A feeling of incomplete bladder emptying
• Waking up multiple times at night to urinate

These symptoms often creep up gradually, making them easy to dismiss until they start interfering with sleep, work, or general comfort.

The Importance of Screening for Prostate Cancer

While BPH is not cancer, men must remain vigilant about prostate cancer, especially because its risk rises with age.

“Prostate cancer in early stages is usually silent,” explains Dr. Malhotra. “That is exactly why screening becomes so important once men cross 50.”

Two common screening tools include:

• PSA (Prostate-Specific Antigen) test
• Digital Rectal Examination (DRE)

These tests help detect abnormalities long before symptoms appear. Early detection not only improves treatment outcomes but also prevents unnecessary anxiety or uncertainty.

Men should also stay alert for red-flag symptoms, including persistent pelvic pain, unexplained weight loss, blood in urine or semen, and sudden urinary changes.

Lifestyle Choices That Support Prostate Health

Beyond medical screening, everyday habits have a strong influence on prostate wellbeing.

Dr. Malhotra emphasizes the role of lifestyle:

“A balanced diet, regular exercise, and maintaining a healthy weight can significantly reduce inflammation and support better prostate function.”

Healthy habits that help include:

• A diet rich in antioxidants (tomatoes, berries, leafy greens)
• Omega-3 sources like fatty fish and walnuts
• Limiting alcohol and caffeine
• Staying well-hydrated
• Avoiding smoking
• Regular physical activity

These choices not only support the prostate but also improve urinary health and hormonal balance.

Since stress can worsen urinary symptoms, incorporating yoga, meditation, or deep-breathing practices also makes a noticeable difference.

Breaking the Silence Around Prostate Health

One of the biggest challenges is the reluctance many men feel when discussing urinary or sexual symptoms.

“Men often suffer quietly because these issues feel too personal,” says Dr. Malhotra. “But silence delays diagnosis and treatment. Open conversations can literally save lives.”

Families, caregivers, and partners can play a supportive role by encouraging early checkups and normalizing discussions around prostate health.

The Bottom Line: Proactive Care Matters

With rising life expectancy and a more active older population, prioritizing prostate health is no longer optional—it’s essential.

Early diagnosis, informed decision-making, and evidence-backed treatments give men the chance to maintain independence, comfort, and quality of life well into their later years.

As Dr. Malhotra puts it, “Prostate health is not just a medical concern—it’s a foundation for staying energetic, confident, and healthy as you age.”

Crossing 40 often brings subtle but noticeable changes in how your body feels and functions. Many people brush off early signs like morning stiffness, reduced flexibility, or frequent bathroom visits, not realizing these are part of natural age-related changes. These shifts primarily affect the bones, joints, and urinary system, areas that quietly define everyday comfort.

According to Dr. Aashish Chaudhry, Managing Director & Head, Orthopedics & Joint Replacement, Aakash Healthcare, these changes are expected but shouldn’t be ignored. “After 40, the body’s regenerative capacity slows down, particularly in bones and joints. Being aware of these changes helps in early prevention and better long-term outcomes,” he says.

Bone Health: Slower Regeneration and Higher Risk of Fractures

Bone density gradually declines with age due to hormonal changes. Women experience a drop in estrogen, and men see reduced testosterone levels—both crucial for supporting bone formation.

“Lower hormone levels weaken the natural bone-building cycle,” explains Dr. Chaudhry. “This increases the risk of fractures and even slows down healing when injuries occur.”

Key concerns include:

• Reduced bone density
• Higher risk of osteoporosis
• Slower fracture recovery

To counter this, weight-bearing exercises and strength training are crucial. A diet rich in calcium, vitamin D, and protein supports bone metabolism and maintains strength.

Joint Health: Wear, Tear, and Early Stiffness

Years of repetitive movements, combined with declining collagen production, make joints more vulnerable. Cartilage becomes less elastic, leading to stiffness, reduced mobility, and the early onset of osteoarthritis.

“Many people notice joint pain but assume it's just fatigue,” says Dr. Chaudhry. “In reality, early joint wear can be detected and managed much earlier with the right interventions.”

What contributes to joint discomfort after 40?

• Natural wear and tear
• Reduced cartilage elasticity
• Slower lubrication of joint spaces
• Early degenerative changes

Flexibility-focused exercises like yoga or stretching, along with anti-inflammatory foods such as leafy greens, berries, nuts, and omega-3 sources, can ease stiffness and protect long-term mobility.

Urinary Changes: More Common Than You Think

While both men and women experience changes in urinary patterns, men often notice symptoms more prominently due to prostate enlargement. A bigger prostate narrows the urinary passage, causing:

• Frequent urination
• Weak urinary stream
• Urgency or incomplete emptying
• Night-time urination

Women, on the other hand, may struggle with pelvic floor weakness, leading to leakage or urgency.

Dr. Chaudhry notes, “These symptoms are common after 40, but they shouldn’t be normalized. Early evaluation can prevent chronic discomfort.”

Hydration remains essential. Cutting back on caffeine, alcohol, and salty foods can also lighten urinary symptoms and prevent kidney irritation.

Lifestyle Adaptations That Make a Real Difference

Shifting from reactive to preventive care is key after 40. The goal isn’t to stop ageing—it's to age comfortably and confidently.

What helps:

• Strength and mobility exercises
• Pelvic floor training
• Maintaining a healthy weight
• Regular health screenings (bone density, kidney tests, prostate evaluation)
• Stress management through yoga, meditation, or deep breathing
• Consistent sleep routines to support tissue repair

“Think of this stage as preparing your body for the next decades,” says Dr. Chaudhry. “With the right lifestyle adjustments, most people can maintain excellent mobility and function well into older age.”

After the Thanksgiving, on Friday, the Food and Drug Administration (FDA)'s top vaccine regulator, Vinay Prasad made a clam that shocked the public-health established. "For the first time, the US FDA will acknowledge that COVID-19 vaccines have killed American children," he wrote in a leaked email to his staff, as reported by The Atlantic and The Washington Post.

The agency has identified that at least 10 children died after getting COVID shots.

The email has been perceived by physicians as a "threat". A response from 12 former FDA commissioners, published in The New England Journal of Medicine on Wednesday, called Prasad's memo "a threat to evidence-based vaccine policy and public health security". All of the potential vaccine related deaths reported to government were already reviewed by the agency's staff, and had reached "different conclusions", wrote the former commissioners.

Elsewhere, doctors and scientists have declared that there are no evidence that links COVID-19 vaccines to deaths in children. The commissioners have claimed that in an attempt to deliberately bring evidence, Prasad and his colleagues had engaged in an "evidence-manufacturing mission", a "dumpster dive" for shoddy data, or worse, a campaign of lying.

Prasad is one of several public health officials who, under Robert F. Kennedy Jr.’s leadership, have been steadily chipping away at public trust in vaccines. So far, he has not provided evidence to back his claims, and his estimate of vaccine-related deaths may be exaggerated. The memo’s intense language and focus on political complaints also cast doubt on his assertions.

However, something that cannot be ignored is that fact that his memo may have provoked people to deny even the possibility of COVID-vaccine-related deaths. The Atlantic notes that "the idea that mRNA-based shots have, tragically, killed a very small number of children is not far-fetched." The article written by Benjamin Mazer, a physician who specializes in pathology and laboratory, notes that the this does not imply a "catastrophic threat to public health" as tens of millions of doses of the same vaccines have saved young people.

Understanding the Debate Of Vaccine-Linked Deaths

Public-health experts agree that COVID vaccines, like all medical treatments, can cause side effects. Myocarditis, a rare heart inflammation seen mostly in adolescent boys and young men after mRNA shots, remains the most discussed risk. Although usually mild and far less severe than virus-induced myocarditis, a few deaths have been documented worldwide, including isolated cases in the U.S., South Korea, and two American teenagers described in a peer-reviewed report.

These findings fuel ongoing debate about whether extremely rare vaccine-related deaths are being overlooked. Some scientists, including Paul Offit and Michael Osterholm, say the evidence does not prove the vaccines caused these deaths, noting that population-level studies show no rise in mortality after vaccination. Others argue that well-investigated autopsy-confirmed cases should be taken seriously rather than dismissed outright.

Experts such as Krutika Kuppalli, as cited by Mazer, emphasize that even if deaths occur, they are so uncommon they do not appear statistically, while the benefits, significantly reduced COVID mortality, are unmistakable. However, individual cases still raise questions on health authorities and the stricter standards of proofs they have applied when vaccines were involved to create a room for skepticism.

The concern is that rare side effects of vaccines could go undiscovered and not that vaccinations are inherently harmful.