For those who have not experienced a migraine, perhaps it would seem just another headache. But for someone like me who has suffered through migraines that will last over a week even with medication, I can definitely tell you that it's much more. The ache is not confined to the head; it's the whole experience. Nausea, sensitivity to light, and throbs so bad it makes simple tasks unbearable. It also comes with an emotional burden—the loneliness and frustration are pretty unbearable. Through the years, realizing how hormones are also implicated in triggering and exacerbating my migraines has helped change the game in my dealing with these episodes.

What are Hormonal Migraines?

Hormonal migraines are caused by fluctuations in estrogen and progesterone, the two main female hormones. These hormones are essential for the reproductive system, regulating menstrual cycles and pregnancy. They also have an effect on brain chemicals, such as serotonin and dopamine, which affect mood and pain perception. When hormone levels fluctuate, such as during menstruation, pregnancy, or menopause, they can destabilize the pathways in the brain, causing migraines.

According to Dr. Shivananda Pai, Consultant Neurology, migraines are more than a neurological disorder. "Migraines represent a complex interplay of genetic, environmental, and hormonal factors. In women, hormonal fluctuations are a critical trigger that amplifies sensitivity to pain," he explains. Hormonal headaches are particularly challenging because they are influenced by multiple life stages, from puberty to post-menopause. Common causes include:

• Menstrual periods: Estrogen levels significantly drop just before menstruation often triggers a migraine.
• Pregnancy: Hormones can act to relieve symptoms or aggravate them during different times of pregnancy.
• Menopause: The hormonal fluctuation during menopause can intensify a migraine, while some women tend to find relief.
• Hormonal therapies: Birth control and HRT tend to level off hormone balances in some individuals but will exacerbate a migraine in others.

Complex Role of Hormones in Women’s Neurological Health

Estrogen and Neurological Health

Estrogen, often called the "hormone of femininity", does more than regulate reproductive functions. It is a powerful influencer of brain health. Estrogen modulates the activity of neurotransmitters like serotonin, which regulates mood and pain perception, and dopamine, associated with reward and pleasure.

During stages of hormonal stability, like in pregnancy's latter months, women may have fewer migraines because of the steady elevation of estrogen. However, a sudden downfall in estrogen destabilizes these chemicals in the brain, sending a heightened sensitivity for migraine triggers.

Menstrual Migraines

The most common form of hormonal migraines is menstrual migraines, which occur in response to the steep decline in estrogen levels just before menstruation. These are typically more intense and less responsive to standard treatment. The timing of these migraines provides clear evidence of the role hormones play in neurological health.

Pregnancy and Hormonal Shifts

Pregnancy is a rollercoaster of hormones. Although many women experience relief from migraines as a result of the constantly elevated levels of estrogen, some women, particularly in the first trimester, worsen. This individual variability is a characteristic of hormonal migraine triggers.

Hormonal Therapies and Management of Migraine

Hormonal treatments, such as oral contraceptives and HRT, have had mixed reviews regarding their use in managing migraine. Some women fare better with the stabilization the treatment provides, whereas others suffer worsening symptoms. This will depend on the nature and dose of the hormones used.

Post-Menopause: Migraine Remission or Continued Struggles?

For most women, menopause brings relief from their migraines. The decline in frequency and severity often accompanies stability in hormone levels. Even so, the susceptibility remains with some towards other forms of triggers including stress and sleep deprivation, not to forget diet-related factors and continues the saga of migraines well after the menopausal stages.

Effect on Neurological Health Due to Hormonal Changes

The relationship of hormones to neurological health goes beyond migraines. Hormonal changes have profound effects on a woman's brain in general.

Mood Disorders: Estrogen helps stabilize mood by regulating serotonin. Its decline at menopause increases the risk of mood swings and depression.

Neurodegenerative Diseases: Estrogen is neuroprotective, stimulating the growth and repair of brain cells. Its absence in post-menopausal women has been associated with an increased risk of Alzheimer's disease and cognitive decline.

Multiple Sclerosis (MS): Hormonal cycles may affect the course of MS, a disease that occurs more frequently in women than in men. Estrogen's anti-inflammatory effects provide transient protection during pregnancy, reducing relapse rates in women with MS.

"The intricate interplay between hormones and neurological health underscores the need for gender-specific treatment approaches," says Dr. Pai.

Managing Hormonal Migraines: Practical Strategies

While hormonal changes are inevitable, several strategies can help manage migraines effectively:

1. Tracking Your Cycle

Understanding your menstrual cycle can help identify patterns and predict when migraines might occur. This knowledge allows for preventive measures, such as scheduling medications or adjusting lifestyle habits.

2. Consulting Specialists

Working with a neurologist or gynecologist can help develop a personalized treatment plan. Options might include hormonal therapies, triptans, or preventive medications tailored to your specific needs.

3. Adopting a Healthy Lifestyle

A well-balanced diet, regular exercise, and stress management are all integral parts of managing migraines. For instance, magnesium-rich foods and hydration can help reduce the frequency and severity of attacks.

4. Exploring Preventive Therapies

For people with severe or frequent migraines, preventive medications, such as beta-blockers or CGRP inhibitors, may be prescribed. These medications stabilize brain activity and therefore reduce the chances of migraine during hormonal fluctuations.

5. Mind-Body Techniques

Techniques like yoga, meditation, and biofeedback can enhance wellness and reduce the debilitating effects of stress-one of the most common migraine triggers.

Research that was once in its embryonic stage continues to shed more light on the role of hormones in migraines and other neurological conditions. Further breakthroughs in genetic testing might enable doctors to predict, at least in a way, how an individual would react to hormonal therapies. The importance of gender-specific approaches is gradually being realized, which involves differentiating between the plight of women with migraines from others.

As Dr. Pai puts it, "Empowering women with knowledge about the hormonal underpinnings of migraines can lead to better, more personalized care. With the right strategies, migraines can be effectively managed, allowing women to lead fuller, healthier lives.

Migraines are not headaches; they are a complex neurological condition that deeply impacts the lives of millions of women. Understanding the role of hormones in triggering and exacerbating migraines is a vital step toward better management and relief.

Awareness, proactive care, and advances in medical research can help women regain their lives from the grip of hormonal migraines. Whether tracking cycles, adopting healthier habits, or seeking tailored medical care, every step taken toward understanding and managing migraines is a step toward empowerment.

Dr Shivananda Pai is a Consultant Neurology at KMC Hospital Dr B R Ambedkar Circle in Mangalore, India.

Brandes JL. The Influence of Estrogen on Migraine: A Systematic Review. JAMA. 2006;295(15):1824–1830. doi:10.1001/jama.295.15.1824

Sacco S, Ricci S, Degan D, Carolei A. Migraine in women: the role of hormones and their impact on vascular diseases. J Headache Pain. 2012 Apr;13(3):177-89. doi: 10.1007/s10194-012-0424-y. Epub 2012 Feb 26. PMID: 22367631; PMCID: PMC3311830.

William, the Prince of Wales, has yet again voiced out concerns about mental health in males, which is often a neglected topic. He also opened up about his emotional struggles and urged men to speak out to normalize the issue.

Speaking to BBC Radio 1, William said it has taken a " long time” for him to understand his “emotions”.

"Learn to love yourself and understand yourself. I take a long time trying to understand my emotions and why I feel like I do, and I feel like that's a really important process to do every now and again, to check in with yourself and work out why you're feeling like you do," said the Prince of Wales.

He emphasized the "need for more male role models" who can speak about their mental health publicly.

"We need more male role models out there, talking about it and normalizing it, so that it becomes second nature to all of us."

"It's OK to ask for support, ask a mate, reach out," said William.

It is not the first time that the Prince has spoken about mental health. Earlier, he stated that people must "relax a little bit and be able to talk about our emotions because we're not robots".

Men And Mental Health

Compared to women, men are known to be less likely to seek help for mental health issues. Driven by stigma, reluctance to seek help, and societal pressures regarding masculinity, men are also more likely to die by suicide.

As per a recent study by The Institute for Health Metrics and Evaluation, University of Washington, US, males die from suicide at twice the rate of females. Their attempts also result in death three times more often than female attempts.

A 2020 paper by the World Health Organization (WHO) identified self-reliance, difficulty in expressing emotions, and self-control as the key sociocultural barriers to men’s help-seeking about masculinity norms.

The National Institute of Mental Health attributed genes, a family history of depression, environmental stress, including financial problems, the loss of a loved one, work problems, a difficult relationship, a major life change, or a stressful situation as major reasons for a decline in mental health in men. Medical conditions like diabetes, heart disease, or cancer are also known to raise the risk of depression in men.

Further, substance use, loneliness, and shame are also contributing factors to the elevated suicide rates among men.

While men and women develop most of the same mental disorders, their symptoms may be different. Some common symptoms among men include:

Anger, irritability, or aggressiveness

Prominent changes in mood, energy level, or appetite

Difficulty sleeping or sleeping too much

Difficulty concentrating, feeling restless, or on edge

Misuse of alcohol, drugs, or both

Many packaged baby foods marketed as healthy may contain hidden sugars and ultra-processed ingredients that can shape a child’s taste preferences and long-term health.

Brightly packaged baby cereals, fruit pouches, snack puffs and flavored yoghurts use “natural”, “organic” and “doctor recommended” labels to advertise their nutritional value and reassure parents.

“What shocked me was the top ingredient in 71% of these baby foods wasn’t a fruit or vegetable, it was one or more additives,” said Dunford, who is also a consultant at The George Institute for Global Health.

However, packaged baby food is instead packed with artificial additives and highly processed components such as carrageenan, xanthan and guar gum.

Why Ultra Processed Baby Foods?

The majority of packaged baby foods are classified as ultraprocessed because they undergo extensive industrial manufacturing and contain ingredients rarely found in a home kitchen.

Rather than using whole, simple foods, many manufacturers rely on heavy processing steps that strip away natural nutrients.

Key Indicators of Ultra Processed Food

Refined Bases: Many ready-to-eat snacks, like puffs, use refined starches and flours as their primary ingredients instead of whole grains.

Not Real Whole Fruit: Many brands often claim whole fruit however; they only provide taste and sweetness without the beneficial fiber and nutrients of the original fruit.

Hidden Sugars and Fillers: Products like flavored cereals frequently contain maltodextrin, added sugars and flavor enhancers to improve palatability.

Industrial Additives: To ensure shelf stability and consistent texture, these foods are often loaded with stabilizers, preservatives, and emulsifiers.

Which Additives That Parents Should Know About?

Even when a product claims to have "no added sugar," it can still be packed with sweeteners. Manufacturers frequently use fruit juice concentrates, corn syrup solids and glucose-based ingredients to enhance flavor.

These concentrated sugars train a baby’s developing palate. Early exposure to intense sweetness can create a lifelong preference for sugary foods, increasing the risk of poor dietary habits in adulthood.

2. "Natural Flavors"

The term "natural flavor" is often misunderstood. While the origin of the flavor must be a natural source, the final additive is often heavily modified in a laboratory.

These substances are engineered to make processed food taste more appealing than it naturally would, which can distort a child's appreciation for the taste of whole, fresh foods.

3. Stabilizers and Gums

To ensure a product looks perfect after sitting on a shelf for months, companies add stabilizers and industrial gums.

These additives create a permanent, uniform texture that prevents the food from separating or changing consistency during storage.

How To know If Baby Food Is Ultra Processed?

Hidden sweeteners: Sweeteners like dextrose, glucose syrup, malt extract, and corn solids are just fancy names for Sugar.

Go For Shorter lists: Avoid long lists of chemical sounding names.

Why Does Early Nutrition Matter?

Nutritious food: Babies require high nourished foods high in vitamins, minerals, healthy fats, and proteins rather than just calories.

Freshness: Fresh consistently provide higher levels of essential nutrients compared to any packaged or processed product.

Palate Programming: This stage establishes a child’s lifelong food habits. Processed baby foods can systematically eliminate whole food choices by training the child to prefer artificial textures and flavors.

Adulthood: Early nutrition is a key pillar of foundational health; the quality of food a baby eats now sets the biological template for their health in adulthood.

How To Give Baby Nutritional Food?

Natural Choices: Simple combinations such as mashed fruits, steamed vegetables, dal, khichdi, and curd provide essential nutrients without artificial components.

Minimal Processing: If buying packaged, choose single-ingredient products, plain vegetable purees or unsweetened cereals to avoid hidden flavors.

NOTE: A shorter ingredient list is always the safest and healthiest choice for your child.

Endometriosis is traditionally defined by the presence of tissue similar to the lining of the uterus, the endometrium growing in locations where it doesn't belong, such as the fallopian tubes, ovaries and pelvic cavity.

Since this tissue is hormonally responsive, it bleeds and causes inflammation during a menstrual cycle.

While experts have long categorized this as a condition solely affecting women, rare clinical cases have shattered this assumption and revealed that the biological blueprint for endometriosis exists in the male body

as well.

What Causes Endometriosis?

• Retrograde menstruation: Fallopian tubes and into the pelvic cavity instead of out of the body. These cells may stick themselves to the inner pelvic lining and organs from where they multiply.

• Transformed peritoneal cells. Hormones or immune factors might transform cells that line the inner side of the abdomen, called peritoneal cells, into cells that are like those that line the inside of the uterus.

• Embryonic cell changes. Hormones such as estrogen may transform embryonic cells in the earliest stages of development into endometrial-like cell growths during puberty.

• Surgical scar complication. Endometrial cells may attach to scar tissue from a cut made during surgery to the stomach area, such as a C-section.

• Endometrial cell transport. The blood vessels or tissue fluid system may move endometrial cells to other parts of the body.

• Immune system condition. A problem with the immune system may make the body unable to recognize and destroy endometriosis tissue.

What Are Symptoms Of Endometriosis?

• Severe Abdominal Pain
• Bloating
• Painful periods
• Pain with sex
• Pain with bowel movements or urination.
• Excessive bleeding
• Infertility
• Fatigue
• Diarrhea
• Constipation
• Nausea

How Does Endometriosis Develop In Men?

They help in the formation of the uterus, cervix, fallopian tubes and upper vagina. However, men develop the Anti Mullerian Hormone, also known as AMH which regresses the formation of these ducts.

Men can develop the ducts when exposed to estrogen. Typically, those who are undergoing prostate cancer treatment, hormone replacement therapy or suffering from obesity take estrogen.

Consistent exposure to estrogen can actually transform those inactive cells or remnants of Mullerian Ducts into endometriosis tissues and pave the way for the development of the disease.

How Common Is Endometriosis?

While the disease is almost diagnosed in women, documented cases in men confirm that they hold the biological potential to develop endometriosis.