Migraines In Women: How Hormones Influence Neurological Health
For those who have not experienced a migraine, perhaps it would seem just another headache. But for someone like me who has suffered through migraines that will last over a week even with medication, I can definitely tell you that it's much more. The ache is not confined to the head; it's the whole experience. Nausea, sensitivity to light, and throbs so bad it makes simple tasks unbearable. It also comes with an emotional burden—the loneliness and frustration are pretty unbearable. Through the years, realizing how hormones are also implicated in triggering and exacerbating my migraines has helped change the game in my dealing with these episodes.
Hormonal migraines are caused by fluctuations in estrogen and progesterone, the two main female hormones. These hormones are essential for the reproductive system, regulating menstrual cycles and pregnancy. They also have an effect on brain chemicals, such as serotonin and dopamine, which affect mood and pain perception. When hormone levels fluctuate, such as during menstruation, pregnancy, or menopause, they can destabilize the pathways in the brain, causing migraines.
According to Dr. Shivananda Pai, Consultant Neurology, migraines are more than a neurological disorder. "Migraines represent a complex interplay of genetic, environmental, and hormonal factors. In women, hormonal fluctuations are a critical trigger that amplifies sensitivity to pain," he explains. Hormonal headaches are particularly challenging because they are influenced by multiple life stages, from puberty to post-menopause. Common causes include:
Estrogen, often called the "hormone of femininity", does more than regulate reproductive functions. It is a powerful influencer of brain health. Estrogen modulates the activity of neurotransmitters like serotonin, which regulates mood and pain perception, and dopamine, associated with reward and pleasure.
During stages of hormonal stability, like in pregnancy's latter months, women may have fewer migraines because of the steady elevation of estrogen. However, a sudden downfall in estrogen destabilizes these chemicals in the brain, sending a heightened sensitivity for migraine triggers.
The most common form of hormonal migraines is menstrual migraines, which occur in response to the steep decline in estrogen levels just before menstruation. These are typically more intense and less responsive to standard treatment. The timing of these migraines provides clear evidence of the role hormones play in neurological health.
Pregnancy is a rollercoaster of hormones. Although many women experience relief from migraines as a result of the constantly elevated levels of estrogen, some women, particularly in the first trimester, worsen. This individual variability is a characteristic of hormonal migraine triggers.
Hormonal treatments, such as oral contraceptives and HRT, have had mixed reviews regarding their use in managing migraine. Some women fare better with the stabilization the treatment provides, whereas others suffer worsening symptoms. This will depend on the nature and dose of the hormones used.
For most women, menopause brings relief from their migraines. The decline in frequency and severity often accompanies stability in hormone levels. Even so, the susceptibility remains with some towards other forms of triggers including stress and sleep deprivation, not to forget diet-related factors and continues the saga of migraines well after the menopausal stages.
The relationship of hormones to neurological health goes beyond migraines. Hormonal changes have profound effects on a woman's brain in general.
Mood Disorders: Estrogen helps stabilize mood by regulating serotonin. Its decline at menopause increases the risk of mood swings and depression.
Neurodegenerative Diseases: Estrogen is neuroprotective, stimulating the growth and repair of brain cells. Its absence in post-menopausal women has been associated with an increased risk of Alzheimer's disease and cognitive decline.
Multiple Sclerosis (MS): Hormonal cycles may affect the course of MS, a disease that occurs more frequently in women than in men. Estrogen's anti-inflammatory effects provide transient protection during pregnancy, reducing relapse rates in women with MS.
"The intricate interplay between hormones and neurological health underscores the need for gender-specific treatment approaches," says Dr. Pai.
While hormonal changes are inevitable, several strategies can help manage migraines effectively:
Understanding your menstrual cycle can help identify patterns and predict when migraines might occur. This knowledge allows for preventive measures, such as scheduling medications or adjusting lifestyle habits.
Working with a neurologist or gynecologist can help develop a personalized treatment plan. Options might include hormonal therapies, triptans, or preventive medications tailored to your specific needs.
A well-balanced diet, regular exercise, and stress management are all integral parts of managing migraines. For instance, magnesium-rich foods and hydration can help reduce the frequency and severity of attacks.
For people with severe or frequent migraines, preventive medications, such as beta-blockers or CGRP inhibitors, may be prescribed. These medications stabilize brain activity and therefore reduce the chances of migraine during hormonal fluctuations.
Techniques like yoga, meditation, and biofeedback can enhance wellness and reduce the debilitating effects of stress-one of the most common migraine triggers.
Research that was once in its embryonic stage continues to shed more light on the role of hormones in migraines and other neurological conditions. Further breakthroughs in genetic testing might enable doctors to predict, at least in a way, how an individual would react to hormonal therapies. The importance of gender-specific approaches is gradually being realized, which involves differentiating between the plight of women with migraines from others.
As Dr. Pai puts it, "Empowering women with knowledge about the hormonal underpinnings of migraines can lead to better, more personalized care. With the right strategies, migraines can be effectively managed, allowing women to lead fuller, healthier lives.
Migraines are not headaches; they are a complex neurological condition that deeply impacts the lives of millions of women. Understanding the role of hormones in triggering and exacerbating migraines is a vital step toward better management and relief.
Awareness, proactive care, and advances in medical research can help women regain their lives from the grip of hormonal migraines. Whether tracking cycles, adopting healthier habits, or seeking tailored medical care, every step taken toward understanding and managing migraines is a step toward empowerment.
Dr Shivananda Pai is a Consultant Neurology at KMC Hospital Dr B R Ambedkar Circle in Mangalore, India.
Brandes JL. The Influence of Estrogen on Migraine: A Systematic Review. JAMA. 2006;295(15):1824–1830. doi:10.1001/jama.295.15.1824
Sacco S, Ricci S, Degan D, Carolei A. Migraine in women: the role of hormones and their impact on vascular diseases. J Headache Pain. 2012 Apr;13(3):177-89. doi: 10.1007/s10194-012-0424-y. Epub 2012 Feb 26. PMID: 22367631; PMCID: PMC3311830.
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Iron deficiency is one of the most common nutritional problems among women, but in the juggle between professional and household responsibilities, a majority of women tend to ignore their health. However, the detecting the mild symptoms in the beginning can help boost treatment and improve quality of life for women, said experts, while stressing the need for timely screening, ahead of International Women's Day.
International Women's Day is observed globally on March 8 every year.
According to health experts, in a month, around 5 out of 10 women between the ages of 30 and 45 visit doctors with complaints such as persistent weakness, headaches, and tiredness. These symptoms are often linked to iron deficiency and put women at risk of developing anemia.
“Iron deficiency is a matter of concern among women, because the symptoms, such as fatigue and weakness, are neglected until the condition becomes serious,” said Dr. Upasana Garg, Regional Technical Chief, Apollo Diagnostic Mumbai.
Dr. Garg said iron deficiency can be detected through simple blood tests that will be advised by the expert and will play a pivotal role in early diagnosis and timely treatment.
These include tests for
Anemia is a major public health concern, mainly affecting young children, pregnant and postpartum women, and menstruating adolescent girls and women.
The World Health Organization (WHO) estimates that 40 percent of all children aged 6–59 months, 37 percent of pregnant women, and 30 percent of women 15–49 years of age worldwide are affected by anemia.
Anemia occurs when there isn’t enough hemoglobin in the body to carry oxygen to the organs and tissues.
In severe cases, anemia can cause poor cognitive and motor development in children. It can also cause problems for pregnant women and their babies. It is often caused by a lack of iron in the blood.
“Iron is a necessary mineral which helps the body to produce hemoglobin, a protein in red blood cells that carries oxygen to different parts of the body. When the body does not have enough iron, it is unable to produce healthy red blood cells. This condition is known as iron deficiency or iron deficiency anemia,” said Dr. Ritu Agrawal, Gynecologist, Zynova Shalby Hospital, Mumbai.
Dr. Agrawal said that women are more likely to experience iron deficiency when compared to men.
The major reason is blood loss during menstruation, and women who have heavy periods are at a higher risk.
During pregnancy, when the body needs extra iron to support the growing baby, the risk of anemia increases in the mother.
Other factors include poor diet, skipping meals, and not eating enough iron-rich foods.
The common symptoms of anemia in women include:
constant tiredness,
weakness,
pale skin,
shortness of breath,
dizziness,
headaches,
hair fall
difficulty concentrating
frequent infections due to reduced immunity
Dr. Agrawal said that 50 percent of women tend to ignore early symptoms of anemia.
“In a month, around 5 out of 10 women between the ages of 30–45 visit with complaints such as persistent weakness, headaches, and tiredness, which are often linked to iron deficiency and put them at risk of developing anemia. If iron deficiency is not treated in time, it can lead to several health complications,” she added.
Severe anemia can also lead to heart-related problems, such as irregular heartbeat or shortness of breath.
The experts noted that detecting iron deficiency on time and initiating immediate treatment is necessary for women's better health.
Management of iron deficiency includes
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American TV personality Oprah Winfrey turned heads at the Paris Fashion Week with her slim figure and sparked talks on the popular weight-loss drug Ozempic.
The now viral videos show Oprah, 72, in jeans and a jacket. Usually seen in parted hair, Oprah also resorted to a ponytail and was wearing tinted sunglasses.
While several netizens expressed concerns about her health, others also spoke about the effects of Ozempic, widely used for weight loss.
“What in the Ozempic Oprah is going on here?”, wrote a user.
“I'm afraid Oprah may OD on Ozempic. Welfare check, please!” another added.
People also commented on the seemingly bigger head and frail body.
“Her head looks way too big for her body. Is it Ozempic or Oprah?” wrote a user.
“She looked good, but she seemed frail,” the netizens said, while another stated, “But having a head that big still is crazy”.
The video also showed Gayle King, another TV host and a longtime friend of Oprah, with a lean figure. Gayle, 71, also rocked a warm-brown look, paired with a fitted top and a black leather jacket.
Oprah has openly shared the use of a GLP-1 agonist for weight loss. However, she never mentioned any brand names.
“One of the things that I realized the very first time I took a GLP-1 was that all these years I thought that thin people just had more willpower, they ate better foods, they were able to stick to it longer, they never had a potato chip, and then I realized the very first time I took the GLP-1 that, 'Oh, they're not even thinking about it. They're only eating when they're hungry, and they're stopping when they're full,” Oprah said in a podcast early in 2025.
In 2023, speaking to People, she said she uses the weight-loss medication as a tool to quiet the food noise.
“I now use it as I feel I need it, as a tool to manage not yo-yoing. It quiets the food noise,” she had told the publication.
In an Instagram post in February 2026, Oprah also showcased her strength training evolution, highlighting the benefits of daily workouts for bone health and her impressive plank progress.
She told her fans that while in 2024, she struggled to hold a plank for more than 10 seconds, now she manages to do a 1-minute plank routine.
While Ozempic was originally developed and FDA-approved as an injectable medication to help manage type 2 diabetes, it has gained immense popularity for its ability to produce significant weight loss.
The drug is popular for its active ingredient, semaglutide, which works by mimicking a hormone that regulates blood sugar and appetite.
However, there are several concerns over its side effects. The loss of lean mass, which includes muscle, has emerged as the biggest concern.
Studies have proven that it provides significant weight loss and also reduces major cardiovascular risks and boosts kidney health, among others.
However, common side effects include:
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She wakes before dawn, packs lunches, manages households, holds careers together, and still finds time to ask everyone else, "Are you okay?" The Indian woman is, in every sense, the backbone of her family. And yet, in giving so much of herself to others, she often becomes the last person she takes care of.
This International Women's Day, that needs to change.
Cancer remains one of the gravest health threats facing Indian women today.
Breast cancer has become the most frequently diagnosed cancer among Indian women — and unlike in Western countries, it is striking women in their 30s and 40s, at the very peak of their lives.
Cervical cancer, though almost entirely preventable, continues to claim thousands of lives every year — not because medicine has failed, but because awareness has.
Ovarian cancer, often called the "silent killer," is frequently caught only at advanced stages, making early vigilance all the more critical.
Thyroid cancer is emerging as a cancer that disproportionately affects women — occurring nearly three times more often in women than men. The good news is that it is also one of the most treatable cancers when detected early.
Women who notice a lump or swelling in the neck, unexplained hoarseness, or difficulty swallowing should not dismiss these signs.
A simple ultrasound and blood test can go a long way in ruling out — or catching — a problem early. The truth, however, is not bleak — it is urgent.
Most cancers, when found at an early stage, are highly treatable. Women above 40 should schedule regular clinical breast examinations and mammography.
Cervical cancer screening through a Pap smear or HPV test, starting as early as age 25–30, can detect precancerous changes before they ever become cancer. These tests are quick, safe, and available — what they need most is for women to simply show up.
Prevention, too, begins with everyday choices. Avoiding tobacco in all its forms — cigarettes, gutka, paan — is the single most powerful step. Regular physical activity, a diet rich in fruits and vegetables, maintaining a healthy weight, limiting alcohol, and getting the "HPV vaccine" (ideally between ages 9 and 14) can dramatically reduce cancer risk.
And perhaps just as importantly: listen to your body. An unusual lump, unexplained bleeding, or a symptom that won't go away is not something to push aside for later. Later can cost everything.
A healthy woman builds a healthy family — and a healthy nation. This Women's Day, let's give every woman around us the most meaningful gift possible: the reminder that her health is not selfish, it is essential.
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