For those who have not experienced a migraine, perhaps it would seem just another headache. But for someone like me who has suffered through migraines that will last over a week even with medication, I can definitely tell you that it's much more. The ache is not confined to the head; it's the whole experience. Nausea, sensitivity to light, and throbs so bad it makes simple tasks unbearable. It also comes with an emotional burden—the loneliness and frustration are pretty unbearable. Through the years, realizing how hormones are also implicated in triggering and exacerbating my migraines has helped change the game in my dealing with these episodes.

What are Hormonal Migraines?

Hormonal migraines are caused by fluctuations in estrogen and progesterone, the two main female hormones. These hormones are essential for the reproductive system, regulating menstrual cycles and pregnancy. They also have an effect on brain chemicals, such as serotonin and dopamine, which affect mood and pain perception. When hormone levels fluctuate, such as during menstruation, pregnancy, or menopause, they can destabilize the pathways in the brain, causing migraines.

According to Dr. Shivananda Pai, Consultant Neurology, migraines are more than a neurological disorder. "Migraines represent a complex interplay of genetic, environmental, and hormonal factors. In women, hormonal fluctuations are a critical trigger that amplifies sensitivity to pain," he explains. Hormonal headaches are particularly challenging because they are influenced by multiple life stages, from puberty to post-menopause. Common causes include:

• Menstrual periods: Estrogen levels significantly drop just before menstruation often triggers a migraine.
• Pregnancy: Hormones can act to relieve symptoms or aggravate them during different times of pregnancy.
• Menopause: The hormonal fluctuation during menopause can intensify a migraine, while some women tend to find relief.
• Hormonal therapies: Birth control and HRT tend to level off hormone balances in some individuals but will exacerbate a migraine in others.

Complex Role of Hormones in Women’s Neurological Health

Estrogen and Neurological Health

Estrogen, often called the "hormone of femininity", does more than regulate reproductive functions. It is a powerful influencer of brain health. Estrogen modulates the activity of neurotransmitters like serotonin, which regulates mood and pain perception, and dopamine, associated with reward and pleasure.

During stages of hormonal stability, like in pregnancy's latter months, women may have fewer migraines because of the steady elevation of estrogen. However, a sudden downfall in estrogen destabilizes these chemicals in the brain, sending a heightened sensitivity for migraine triggers.

Menstrual Migraines

The most common form of hormonal migraines is menstrual migraines, which occur in response to the steep decline in estrogen levels just before menstruation. These are typically more intense and less responsive to standard treatment. The timing of these migraines provides clear evidence of the role hormones play in neurological health.

Pregnancy and Hormonal Shifts

Pregnancy is a rollercoaster of hormones. Although many women experience relief from migraines as a result of the constantly elevated levels of estrogen, some women, particularly in the first trimester, worsen. This individual variability is a characteristic of hormonal migraine triggers.

Hormonal Therapies and Management of Migraine

Hormonal treatments, such as oral contraceptives and HRT, have had mixed reviews regarding their use in managing migraine. Some women fare better with the stabilization the treatment provides, whereas others suffer worsening symptoms. This will depend on the nature and dose of the hormones used.

Post-Menopause: Migraine Remission or Continued Struggles?

For most women, menopause brings relief from their migraines. The decline in frequency and severity often accompanies stability in hormone levels. Even so, the susceptibility remains with some towards other forms of triggers including stress and sleep deprivation, not to forget diet-related factors and continues the saga of migraines well after the menopausal stages.

Effect on Neurological Health Due to Hormonal Changes

The relationship of hormones to neurological health goes beyond migraines. Hormonal changes have profound effects on a woman's brain in general.

Mood Disorders: Estrogen helps stabilize mood by regulating serotonin. Its decline at menopause increases the risk of mood swings and depression.

Neurodegenerative Diseases: Estrogen is neuroprotective, stimulating the growth and repair of brain cells. Its absence in post-menopausal women has been associated with an increased risk of Alzheimer's disease and cognitive decline.

Multiple Sclerosis (MS): Hormonal cycles may affect the course of MS, a disease that occurs more frequently in women than in men. Estrogen's anti-inflammatory effects provide transient protection during pregnancy, reducing relapse rates in women with MS.

"The intricate interplay between hormones and neurological health underscores the need for gender-specific treatment approaches," says Dr. Pai.

Managing Hormonal Migraines: Practical Strategies

While hormonal changes are inevitable, several strategies can help manage migraines effectively:

1. Tracking Your Cycle

Understanding your menstrual cycle can help identify patterns and predict when migraines might occur. This knowledge allows for preventive measures, such as scheduling medications or adjusting lifestyle habits.

2. Consulting Specialists

Working with a neurologist or gynecologist can help develop a personalized treatment plan. Options might include hormonal therapies, triptans, or preventive medications tailored to your specific needs.

3. Adopting a Healthy Lifestyle

A well-balanced diet, regular exercise, and stress management are all integral parts of managing migraines. For instance, magnesium-rich foods and hydration can help reduce the frequency and severity of attacks.

4. Exploring Preventive Therapies

For people with severe or frequent migraines, preventive medications, such as beta-blockers or CGRP inhibitors, may be prescribed. These medications stabilize brain activity and therefore reduce the chances of migraine during hormonal fluctuations.

5. Mind-Body Techniques

Techniques like yoga, meditation, and biofeedback can enhance wellness and reduce the debilitating effects of stress-one of the most common migraine triggers.

Research that was once in its embryonic stage continues to shed more light on the role of hormones in migraines and other neurological conditions. Further breakthroughs in genetic testing might enable doctors to predict, at least in a way, how an individual would react to hormonal therapies. The importance of gender-specific approaches is gradually being realized, which involves differentiating between the plight of women with migraines from others.

As Dr. Pai puts it, "Empowering women with knowledge about the hormonal underpinnings of migraines can lead to better, more personalized care. With the right strategies, migraines can be effectively managed, allowing women to lead fuller, healthier lives.

Migraines are not headaches; they are a complex neurological condition that deeply impacts the lives of millions of women. Understanding the role of hormones in triggering and exacerbating migraines is a vital step toward better management and relief.

Awareness, proactive care, and advances in medical research can help women regain their lives from the grip of hormonal migraines. Whether tracking cycles, adopting healthier habits, or seeking tailored medical care, every step taken toward understanding and managing migraines is a step toward empowerment.

Dr Shivananda Pai is a Consultant Neurology at KMC Hospital Dr B R Ambedkar Circle in Mangalore, India.

Brandes JL. The Influence of Estrogen on Migraine: A Systematic Review. JAMA. 2006;295(15):1824–1830. doi:10.1001/jama.295.15.1824

Sacco S, Ricci S, Degan D, Carolei A. Migraine in women: the role of hormones and their impact on vascular diseases. J Headache Pain. 2012 Apr;13(3):177-89. doi: 10.1007/s10194-012-0424-y. Epub 2012 Feb 26. PMID: 22367631; PMCID: PMC3311830.

For the first time, the number of centenarians in Japan has exceeded 100,000. According to the latest figures from the health ministry, the country now has 107,677 people aged 100 and above, of whom 88% are women.

The oldest woman is Kishimoto Fuyo, a 114-year-old from Kyoto City, while the oldest man is Kato Hikaru, a 112-year-old from Kumamoto.

Health Minister Kenichiro Ueno told reporters he was “delighted that so many people are living long, healthy and active lives”. Citing progress in medicine and technology behind the long life, Ueno also warned about the challenge of maintaining a sustainable social security system.

Why Is Japan A Super-Ageing Society?

The long lives of Japanese people may be attributed to several factors, including genetics, a healthy diet and an active lifestyle.

The island nation’s cuisine predominantly consists of fish, vegetables and rice, with less saturated fat than many Western diets. Older people also regularly walk, use public transport, cycle and stretch.

However, Japan’s ageing population is linked to two major demographic trends: low birth rates and longer life expectancy.

Fertility falling below the replacement level means fewer younger people are entering the population, while improvements in healthcare allow people to live longer.

To curb the falling fertility rates, the government in 2023 launched programs aimed at increasing the birth rate, including a 3.5-trillion-yen (US$22.5 billion) increase in family-policy spending.

However, the country's total fertility rate still dropped to a record low of 1.14 in 2025, far below the 2.1 children needed to maintain the current population.

On the other hand, there were 153 people aged 100 or older when centenarian surveys began in 1963. The number exceeded 1,000 in 1981 and surpassed 10,000 in 1998, according to the Health and Welfare Ministry.

Also read: Unusually High Cancer-Fighting Immune Cells Could Explain Why Some People Live Beyond 100: Study

What Are The Challenges Of A Super-Ageing Society?

The World Health Organization defines “super-ageing” societies as countries where more than 20% of the population is aged 65 or older.

As the proportion of older adults grows relative to the working-age population, population ageing can place pressure on healthcare systems, economies and social support structures. It can also contribute to challenges such as pension pressures, labor shortages and increasing demand for long-term care.

An ageing population can increase the need for continuous medical care, caregiving and social support, due to

• Chronic disease burden of heart disease, diabetes, cancer and cognitive
• Resource strain, where Hospitals and nursing homes face shortages of specialized geriatric care personnel and integrated support services.
• Social isolation, where loss of community engagement and inadequate public transportation or age-friendly housing can increase vulnerability.
• Elder mistreatment: Social and family abuse, alongside systemic ageism, can undermine the dignity and safety of older citizens.

Read More: Normal Ageing or Alzheimer's? Doctors Explain Six Key Differences to Watch For'

Ageing Is Becoming A Global Challenge

Japan’s demographic shift is part of a broader global trend. According to WHO, by 2030, one in six people worldwide will be aged 60 or older. The number of people aged 60 and above is projected to rise from 1 billion in 2020 to 1.4 billion by 2030.

By 2050, the global population aged 60 and older is expected to reach 2.1 billion. The number of people aged 80 or older is also expected to triple between 2020 and 2050, reaching 426 million.

By 2050, two-thirds of the world’s population aged over 60 is expected to live in low- and middle-income countries.

Population ageing therefore has implications not only for how long people live, but also for healthcare, caregiving, social support and the size of the working-age population.

Climate change is an environmental issue, but its effects are reaching the eye clinic. Hotter summers, intense ultraviolet radiation, polluted air, shifting pollen seasons and extreme rainfall can affect the eyes.

Because the eye’s surface is exposed to the environment, changes in temperature, humidity and air quality may produce symptoms. Five risks deserve attention in India.

Heat and Dry-Eye Disease

Extreme heat, dry winds and prolonged air-conditioning can accelerate evaporation of the tear film that protects the eye. Dehydration may compound the problem. Burning, grittiness, redness, watering and blurred vision are common warning signs.

Outdoor workers, drivers, older adults and contact-lens users may be especially vulnerable. Hydration, protective glasses and preservative-free lubricating drops recommended by an ophthalmologist can help.

Cumulative Ultraviolet Damage

Sunlight can affect more than the skin. Acute, intense ultraviolet exposure may injure the corneal surface and cause photokeratitis, producing pain, watering, light sensitivity and blurred vision. Exposure over years is associated with pterygium a fleshy growth on the eye and certain forms of cataract.

Choose sunglasses labelled UV400 or offering 99–100 per cent UVA and UVB protection. Dark lenses without verified UV protection are not adequate. A broad-brimmed hat provides protection.

Also read: US FDA Launches Expedited IND Pilot To Speed Up Drug Trials

Air Pollution and Ocular-Surface Inflammation

Particulate matter, vehicle emissions, smoke, ozone and construction dust come into direct contact with the tear film. They may destabilise it and trigger inflammation, worsening dry eye, redness and allergic conjunctivitis. On days with poor air quality, limit avoidable outdoor exposure, use wraparound glasses and avoid rubbing the eyes.

Artificial tears may wash irritants from the surface, but persistent symptoms require examination rather than repeated use of over-the-counter “whitening” drops.

Longer Allergy Seasons

Changing temperatures, rainfall patterns and plant cycles can alter the amount and timing of airborne pollen. Combined with dust and pollution, this may result in more frequent or prolonged allergic-eye symptoms. Intense itching, watering and swollen eyelids are typical.

Cold compresses can provide relief, but rubbing may damage the ocular surface and, in susceptible people, contribute to corneal problems. Anti-allergy drops should be selected with medical guidance. Steroid eye drops must never be self-prescribed because misuse can raise eye pressure, promote infection and damage vision.

Also read: Bouncy Castles Linked To MRSA Outbreak In 48 Children In Ireland

Eye Infections After Extreme Rainfall and Flooding

Heavy rain, waterlogging and disrupted sanitation increase exposure to contaminated water and surfaces. Crowding during outbreaks may also facilitate the spread of infectious conjunctivitis through hands, towels, cosmetics and shared personal items.

Do not splash floodwater or questionable tap water into the eyes, and never rinse contact lenses with water. Pain, marked light sensitivity, reduced vision, corneal whiteness or symptoms in a contact-lens wearer require urgent assessment.

Climate-related eye problems are not confined to one season. Prevention begins with UV protection, clean hands, hydration, sensible exposure reduction and timely eye examinations. Sudden loss of vision, severe pain, flashes, new floaters or an eye injury should always be treated as an emergency.

More women in the US and UK are seeking testosterone to manage menopause symptoms, with some turning to online pharmacies without a prescription, according to media reports.

There are no US Food and Drug Administration (FDA)-approved testosterone products specifically indicated for women. Australia has approved a low-dose testosterone product for postmenopausal women, while the UK and New Zealand permit some female-dosed formulations, although availability varies.

What’s Happening In The US?

Reuters reported that off-label testosterone use is rising in the US, mainly to treat persistently low sexual desire associated with menopause. Some clinicians are also prescribing testosterone for symptoms such as fatigue and loss of muscle strength, despite a lack of medical guidance supporting these uses.

Prescriptions for low sexual desire reportedly rose 146% between January 2023 and July 2026. However, many pharmacies and health insurers continue to deny these prescriptions.

Also read: US Congress To Hold First-ever Menopause Hearing: Why It Matters For Women

Why Are UK Women Turning To Testosterone?

The BBC reported that some women in Wales are posing as men to buy testosterone from online pharmacies because of difficulties accessing NHS prescriptions.

There has also been a “very sharp increase” in testosterone referrals to the NHS for postmenopausal women.

Menopause specialist Dr Michelle Olver said she had seen women with testosterone levels up to 12 times the safe level after buying the hormone online, putting them at risk of permanent side effects.

Why Is Testosterone Gaining Attention?

Also read: ‘I Was Vocal About Cancer But Silent About Menopause Out Of Shame’, Says Actress Lisa Ray

Although testosterone is often called a male hormone, women also produce it, primarily through the ovaries and adrenal glands. Levels generally decline with age.

Some women are prescribed testosterone for distressing loss of sexual desire. Others are seeking it for fatigue, impaired thinking, low mood and loss of muscle strength.

The FDA is set to hold a public workshop on September 17 to examine testosterone use in menopausal women. The agency says off-label use is growing, while questions remain about its effects on sexual function, mood, cognition, muscle and bone health, as well as long-term cardiovascular and breast cancer safety.

What Does The Evidence Say?

Menopause does not automatically mean a woman has a “testosterone deficiency.”

Notably, there is no established testosterone level below which an otherwise healthy woman is diagnosed as testosterone deficient. A blood test alone also cannot determine whether low testosterone is responsible for symptoms such as fatigue, low mood or loss of sexual desire.

However, the Menopause Society and other medical organizations support testosterone use in menopausal women with hypoactive sexual desire disorder.

“We do not have any evidence in women that it will improve muscle mass or bone density or mood or well-being or really any other metric,” said Dr Stephanie Faubion, director of Mayo Clinic's Center for Women's Health and medical director of The Menopause Society.

“What testosterone is being touted for in the lay public and on social media is not really what we have data for,” she said.

Are There Any Side Effects?

According to Cleveland Clinic, testosterone treatment generally isn’t recommended for women with cardiovascular disease, liver disease or hormone-sensitive cancers such as breast or uterine cancer.

Excess testosterone can cause acne, increased facial or body hair and scalp hair loss. Higher doses may also lead to voice deepening and clitoral enlargement, some of which can be irreversible.

Testosterone should therefore not be used in higher doses as a way to boost energy, muscle strength or libido.