For those who have not experienced a migraine, perhaps it would seem just another headache. But for someone like me who has suffered through migraines that will last over a week even with medication, I can definitely tell you that it's much more. The ache is not confined to the head; it's the whole experience. Nausea, sensitivity to light, and throbs so bad it makes simple tasks unbearable. It also comes with an emotional burden—the loneliness and frustration are pretty unbearable. Through the years, realizing how hormones are also implicated in triggering and exacerbating my migraines has helped change the game in my dealing with these episodes.

What are Hormonal Migraines?

Hormonal migraines are caused by fluctuations in estrogen and progesterone, the two main female hormones. These hormones are essential for the reproductive system, regulating menstrual cycles and pregnancy. They also have an effect on brain chemicals, such as serotonin and dopamine, which affect mood and pain perception. When hormone levels fluctuate, such as during menstruation, pregnancy, or menopause, they can destabilize the pathways in the brain, causing migraines.

According to Dr. Shivananda Pai, Consultant Neurology, migraines are more than a neurological disorder. "Migraines represent a complex interplay of genetic, environmental, and hormonal factors. In women, hormonal fluctuations are a critical trigger that amplifies sensitivity to pain," he explains. Hormonal headaches are particularly challenging because they are influenced by multiple life stages, from puberty to post-menopause. Common causes include:

• Menstrual periods: Estrogen levels significantly drop just before menstruation often triggers a migraine.
• Pregnancy: Hormones can act to relieve symptoms or aggravate them during different times of pregnancy.
• Menopause: The hormonal fluctuation during menopause can intensify a migraine, while some women tend to find relief.
• Hormonal therapies: Birth control and HRT tend to level off hormone balances in some individuals but will exacerbate a migraine in others.

Complex Role of Hormones in Women’s Neurological Health

Estrogen and Neurological Health

Estrogen, often called the "hormone of femininity", does more than regulate reproductive functions. It is a powerful influencer of brain health. Estrogen modulates the activity of neurotransmitters like serotonin, which regulates mood and pain perception, and dopamine, associated with reward and pleasure.

During stages of hormonal stability, like in pregnancy's latter months, women may have fewer migraines because of the steady elevation of estrogen. However, a sudden downfall in estrogen destabilizes these chemicals in the brain, sending a heightened sensitivity for migraine triggers.

Menstrual Migraines

The most common form of hormonal migraines is menstrual migraines, which occur in response to the steep decline in estrogen levels just before menstruation. These are typically more intense and less responsive to standard treatment. The timing of these migraines provides clear evidence of the role hormones play in neurological health.

Pregnancy and Hormonal Shifts

Pregnancy is a rollercoaster of hormones. Although many women experience relief from migraines as a result of the constantly elevated levels of estrogen, some women, particularly in the first trimester, worsen. This individual variability is a characteristic of hormonal migraine triggers.

Hormonal Therapies and Management of Migraine

Hormonal treatments, such as oral contraceptives and HRT, have had mixed reviews regarding their use in managing migraine. Some women fare better with the stabilization the treatment provides, whereas others suffer worsening symptoms. This will depend on the nature and dose of the hormones used.

Post-Menopause: Migraine Remission or Continued Struggles?

For most women, menopause brings relief from their migraines. The decline in frequency and severity often accompanies stability in hormone levels. Even so, the susceptibility remains with some towards other forms of triggers including stress and sleep deprivation, not to forget diet-related factors and continues the saga of migraines well after the menopausal stages.

Effect on Neurological Health Due to Hormonal Changes

The relationship of hormones to neurological health goes beyond migraines. Hormonal changes have profound effects on a woman's brain in general.

Mood Disorders: Estrogen helps stabilize mood by regulating serotonin. Its decline at menopause increases the risk of mood swings and depression.

Neurodegenerative Diseases: Estrogen is neuroprotective, stimulating the growth and repair of brain cells. Its absence in post-menopausal women has been associated with an increased risk of Alzheimer's disease and cognitive decline.

Multiple Sclerosis (MS): Hormonal cycles may affect the course of MS, a disease that occurs more frequently in women than in men. Estrogen's anti-inflammatory effects provide transient protection during pregnancy, reducing relapse rates in women with MS.

"The intricate interplay between hormones and neurological health underscores the need for gender-specific treatment approaches," says Dr. Pai.

Managing Hormonal Migraines: Practical Strategies

While hormonal changes are inevitable, several strategies can help manage migraines effectively:

1. Tracking Your Cycle

Understanding your menstrual cycle can help identify patterns and predict when migraines might occur. This knowledge allows for preventive measures, such as scheduling medications or adjusting lifestyle habits.

2. Consulting Specialists

Working with a neurologist or gynecologist can help develop a personalized treatment plan. Options might include hormonal therapies, triptans, or preventive medications tailored to your specific needs.

3. Adopting a Healthy Lifestyle

A well-balanced diet, regular exercise, and stress management are all integral parts of managing migraines. For instance, magnesium-rich foods and hydration can help reduce the frequency and severity of attacks.

4. Exploring Preventive Therapies

For people with severe or frequent migraines, preventive medications, such as beta-blockers or CGRP inhibitors, may be prescribed. These medications stabilize brain activity and therefore reduce the chances of migraine during hormonal fluctuations.

5. Mind-Body Techniques

Techniques like yoga, meditation, and biofeedback can enhance wellness and reduce the debilitating effects of stress-one of the most common migraine triggers.

Research that was once in its embryonic stage continues to shed more light on the role of hormones in migraines and other neurological conditions. Further breakthroughs in genetic testing might enable doctors to predict, at least in a way, how an individual would react to hormonal therapies. The importance of gender-specific approaches is gradually being realized, which involves differentiating between the plight of women with migraines from others.

As Dr. Pai puts it, "Empowering women with knowledge about the hormonal underpinnings of migraines can lead to better, more personalized care. With the right strategies, migraines can be effectively managed, allowing women to lead fuller, healthier lives.

Migraines are not headaches; they are a complex neurological condition that deeply impacts the lives of millions of women. Understanding the role of hormones in triggering and exacerbating migraines is a vital step toward better management and relief.

Awareness, proactive care, and advances in medical research can help women regain their lives from the grip of hormonal migraines. Whether tracking cycles, adopting healthier habits, or seeking tailored medical care, every step taken toward understanding and managing migraines is a step toward empowerment.

Dr Shivananda Pai is a Consultant Neurology at KMC Hospital Dr B R Ambedkar Circle in Mangalore, India.

Brandes JL. The Influence of Estrogen on Migraine: A Systematic Review. JAMA. 2006;295(15):1824–1830. doi:10.1001/jama.295.15.1824

Sacco S, Ricci S, Degan D, Carolei A. Migraine in women: the role of hormones and their impact on vascular diseases. J Headache Pain. 2012 Apr;13(3):177-89. doi: 10.1007/s10194-012-0424-y. Epub 2012 Feb 26. PMID: 22367631; PMCID: PMC3311830.

Over 57 million people worldwide live with dementia, causing 36.3 million disability-adjusted life years (DALYs) and ranking as the seventh leading cause of death. But when it comes to dementia, memory loss is often the first symptom that comes to mind.

While forgetting birthdays or losing keys are commonly considered early warning signs of dementia, this may not always be the case.

Experts say a person can remember every birthday and anniversary and still have dementia.

What Are The Early Signs Of Dementia?

“Dementia may not begin with memory loss. It can begin with smell, language, personality or navigation,” Dr Priyam Bordoloi, an internal medicine resident from Assam, said in a post on the social media platform X.

1. Loss Of Smell: When Coffee Stops Smelling Like Coffee

Dr Priyam noted that loss of smell can be an early sign, but it is often overlooked because it may be attributed to a viral illness, sinus disease, smoking, medicines or a head injury.

“Persistent, unexplained smell loss may also be an early clue to Parkinson’s disease or dementia with Lewy bodies,” he added.

2. Everyday Words Start Disappearing

It is not simply an occasional tip-of-the-tongue moment. “In primary progressive aphasia, word-finding, grammar or comprehension may worsen while recent memory stays intact,” Dr Priyam noted.

3. The Family Says, “They Are Not The Same”

Changes in personality or behaviour may sometimes appear before memory problems.

“In behavioral-variant frontotemporal dementia, apathy, impulsiveness, loss of empathy or poor judgment may come before memory loss,” Dr Priyam said.

4. A Familiar Route Suddenly Feels New

Families may notice navigation problems even when a person has no obvious memory complaints. “Families ask me, ‘He has driven there for 20 years. How did he get lost?’ When it repeats, I look beyond forgetfulness,” Dr Priyam said.

He noted that visuospatial dysfunction can appear early in dementia with Lewy bodies or posterior cortical atrophy.

One Odd Symptom Does Not Necessarily Mean Dementia

Dr Parveen Yograj, a general surgeon from Jammu, added that one unusual symptom alone means little.

"A new, persistent and progressive pattern that disrupts daily life and is noticed by loved ones is what demands attention," he said on X.

How Can Dementia Risk Be Reduced?

Dr Yograj said several lifestyle measures may help protect brain health and reduce the risk of cognitive decline.

• Exercise Regularly: Regular aerobic exercise along with strength training can boost brain blood flow and build cognitive reserve.
• Follow A Brain-Healthy Diet: A Mediterranean or MIND diet, rich in vegetables, berries, nuts, olive oil and fish, can support vascular health.
• Prioritize Good Sleep: Solid sleep helps clear toxic brain waste and supports overall brain health.
• Keep Blood Pressure, Sugar And Cholesterol In Check: Managing blood pressure, blood sugar, cholesterol and weight can help reduce the risk of vascular dementia.
• Stay Socially And Mentally Active: Stay socially connected and mentally engaged by talking with others, reading, learning new skills and playing games.
• Quit Smoking And Limit Alcohol: Avoiding smoking, limiting alcohol and treating hearing loss early can also support long-term brain health.

Organ transplantation can offer patients with end-stage organ failure a new opportunity for a longer, healthier, and more independent life. However, transplantation is not the end of treatment—it marks the beginning of a lifelong commitment to maintaining the health and function of the transplanted organ.

Successful long-term outcomes depend on close collaboration between the organ recipient, living donor, transplant team, and family. Regular medical follow-up, adherence to prescribed medications, a healthy lifestyle, and early recognition of warning signs are essential for both recipients and living donors.

Care After Organ Transplantation

1. Strict Adherence to Immunosuppressive Medications

For most solid-organ transplant recipients, lifelong immunosuppressive therapy is required to prevent the immune system from attacking the transplanted organ.

Medications such as tacrolimus, cyclosporine, mycophenolate, corticosteroids, and other immunosuppressive agents may be prescribed depending on the type of transplant and the individual patient's condition.

Recipients should:

• Take medications exactly as prescribed and at the recommended times.

• Never stop or reduce immunosuppressive medication without consulting the transplant team.

• Avoid missing doses.

• Inform their transplant physician before starting any new medication.

Even seemingly minor changes in medication can affect drug levels and may increase the risk of acute or chronic rejection.

Also read: World Organ Donation Day 2026: Too Old Or Too Sick To Donate Organs? Doctors Bust Key Myths

2. Regular Follow-Up and Laboratory Monitoring

Regular follow-up with the transplant team is an essential component of lifelong transplant care.

Depending on the transplanted organ and individual circumstances, monitoring may include:

• Kidney and liver function tests

• Complete blood counts

• Immunosuppressive drug levels

• Blood pressure and blood glucose monitoring

• Urine examination in kidney transplant recipients

• Imaging or other investigations when clinically indicated

These evaluations help detect rejection, infection, medication toxicity, or deterioration in graft function at an early stage, sometimes before symptoms become apparent.

Also read: US HHS Action Against Kentucky Organ Donation Group Raises Questions About Transplant Safety

3. Recognizing Warning Signs

Transplant recipients should promptly contact their transplant team if they develop symptoms such as:

• Unexplained or persistent fever

• Chills or significant weakness

• Reduced urine output, particularly after kidney transplantation

• Swelling or sudden weight gain

• Breathlessness or persistent cough

• Persistent pain over the transplant site

• Persistent vomiting or diarrhoea

• Unexplained changes in blood pressure or blood sugar

Because immunosuppressive medications reduce the body's immune response, infections may develop more easily and may sometimes present with subtle symptoms. Early medical assessment is therefore important.

4. Infection Prevention

Transplant recipients are more susceptible to infections, particularly during periods of intensive immunosuppression.

Important preventive measures include:

• Practising regular hand hygiene

• Avoiding close contact with individuals who have contagious infections

• Following appropriate food-safety precautions

• Drinking safe and hygienic water

• Maintaining good personal hygiene

• Keeping vaccinations up to date as advised by the transplant team

• Seeking medical advice promptly if symptoms of infection develop

Recipients should also follow the specific infection-prevention recommendations provided by their transplant centre.

5. Healthy Nutrition and Lifestyle

A balanced and nutritious diet is an important component of long-term transplant health.

Recipients should aim to:

• Maintain a healthy body weight

• Eat a balanced diet rich in vegetables, fruits, whole grains, and appropriate sources of protein

• Maintain adequate hydration unless fluid restriction has been advised

• Limit excessive salt, sugar, and processed foods

• Exercise regularly according to their medical condition and physician's advice

• Avoid smoking and tobacco products

• Avoid excessive alcohol consumption

Certain foods, supplements, and herbal preparations may interact with immunosuppressive medications. No dietary supplement, herbal preparation, or over-the-counter medication should be started without discussing it with the transplant team.

Also read: AIIMS Performs Second Dual Kidney Transplant Using Organs From 70-Year-Old Donor: How It Can Expand Donor Pool?

Post-Donation Care for Living Organ Donors

Living organ donation is a remarkable act of generosity. However, protecting the donor's long-term health remains the highest priority.

After donation, the donor should remain under appropriate medical supervision and follow the recommendations of the transplant and surgical team.

1. Recovery After Donation

The recovery period varies depending on the type of donation and the individual's overall health.

Donors should:

• Follow wound-care instructions carefully.

• Take prescribed medications as directed.

• Get adequate rest during the initial recovery period.

• Gradually resume physical activity as advised.

• Avoid strenuous exercise and heavy lifting until medically cleared.

• Return to work and normal activities progressively.

The recovery process should be individualized rather than based solely on a fixed timeline.

2. Long-Term Health After Kidney Donation

Most carefully selected kidney donors can lead healthy, active lives with a single functioning kidney.

Long-term health recommendations include:

• Maintaining a healthy body weight

• Exercising regularly

• Eating a balanced diet

• Staying adequately hydrated

• Avoiding tobacco

• Avoiding unnecessary use of potentially kidney-toxic medications, particularly certain painkillers such as NSAIDs

• Monitoring blood pressure

• Periodically checking kidney function and urine as recommended

Living donation should never mean that donors stop looking after their own health. The donor's well-being remains a lifelong priority.

Any new or persistent symptoms should be reported to a healthcare professional.

Also read: India Records 20,138 Organ Transplants In 2025; Deceased Donor Transplants Reach 3,526

3. Emotional and Psychological Well-Being

Transplantation and organ donation can have a significant emotional impact on both recipients and donors.

Recipients may experience anxiety related to rejection, medication, financial concerns, or the uncertainty associated with transplantation. Living donors may also experience emotional changes during the recovery period.

Maintaining open communication with family members and the transplant team can be extremely helpful. If persistent anxiety, depression, sleep disturbances, or emotional distress develops, professional psychological or psychiatric support should be sought.

4. The Importance of Lifelong Follow-Up

The success of organ transplantation depends not only on the surgical procedure but also on long-term post-transplant care.

For recipients, medication adherence, regular monitoring, infection prevention, and a healthy lifestyle are essential to preserving graft function.

For living donors, appropriate postoperative recovery, long-term health monitoring, and healthy lifestyle practices help ensure that they continue to live healthy and fulfilling lives after donation.

The transplant may be a single surgical event—but maintaining the gift of life is a lifelong journey.

With appropriate medical supervision, adherence to treatment, healthy lifestyle choices, and timely attention to warning signs, organ recipients can protect the health of their transplanted organ, while living donors can continue to enjoy a healthy and active life after their selfless contribution.

By Dr. Pragnesh Desai, Senior Director & HOD – Urology, Renal Transplant, Robotics & Uro-Oncology, Yatharth Super Speciality Hospital, Noida Extension

Organ donation is one of the most generous gifts a person can give. Age, diabetes, hypertension or other medical conditions do not automatically rule out organ donation, doctors said on World Organ Donation Day.

Observed on August 13 every year, World Organ Donation Day aims to raise awareness about the need for organ and tissue donation and honour donors and their families.

Organ Donation After Brain Death

Dr. Umesh Gupta, Director and HOD, Nephrology and Kidney Transplant, Aakash Healthcare Multi-Speciality Hospital, Dwarka, told HealthandMe that organ donation can be considered when brain function is permanently lost and cannot be restored.

Brain death occurs when all functions of the brain and brainstem have permanently stopped.

“Brain death is different from a coma or a prolonged unconscious state. In brain death, the person cannot regain consciousness or breathe independently. Mechanical support may continue to keep the heart beating and preserve the condition of organs for a limited period, which is why organ donation can be considered,” he said.

Depending on the donor’s medical condition, organs such as the heart, liver, kidneys, lungs and pancreas may be suitable for transplantation.

Who Can Donate Organs?

Age alone does not rule out organ donation. Eligibility is assessed individually by the transplant team.

Doctors evaluate:

• Health and functioning of individual organs
• Existing illnesses
• Infections
• Medical history
• Other factors that could affect transplant safety

Can People With Diabetes or Hypertension Donate?

People with well-controlled diabetes or hypertension may still be eligible to donate certain organs or tissues, said Dr. Shailesh Chandra Sahay, Senior Director - Urology, Kidney Transplant, Robotic Surgery, Max Super Speciality Hospital, Patparganj.

Modern transplantation practices allow doctors to assess each organ individually rather than excluding a donor solely because of age or a particular diagnosis.

Every potential donor deserves a medical evaluation. An organ that may appear unsuitable to a person could ultimately give another patient a second chance at life.

Blood Group Is Important — But Not the Only Factor

Blood group compatibility is an important consideration in organ transplantation.

“A blood group O donor typically donates to O recipients, while AB recipients can receive organs from all ABO blood groups in many transplant settings,” Dr. Saurabh said.

However, compatibility involves more than blood type. Doctors also assess:

• Tissue compatibility
• Antibodies
• Organ size
• Recipient’s overall health

World Organ Donation Day 2026: Why Donation Matters

• One deceased donor can potentially save up to eight lives through vital organ donation.
• Tissue donation can improve the lives of many more people.
• A record 173,727 solid-organ transplants were performed worldwide in 2024, but demand continues to exceed supply.
• India performed 20,019 organ transplants in 2025, nearly four times the number in 2013.
• As of March 3, 2026, 89,839 patients were on India’s national waiting list for major organs.
• Only around 18% of transplants currently involve deceased-donor organs.
• More than 4.8 lakh Indians have pledged to donate organs and tissues after death since September 2023.