For those who have not experienced a migraine, perhaps it would seem just another headache. But for someone like me who has suffered through migraines that will last over a week even with medication, I can definitely tell you that it's much more. The ache is not confined to the head; it's the whole experience. Nausea, sensitivity to light, and throbs so bad it makes simple tasks unbearable. It also comes with an emotional burden—the loneliness and frustration are pretty unbearable. Through the years, realizing how hormones are also implicated in triggering and exacerbating my migraines has helped change the game in my dealing with these episodes.

What are Hormonal Migraines?

Hormonal migraines are caused by fluctuations in estrogen and progesterone, the two main female hormones. These hormones are essential for the reproductive system, regulating menstrual cycles and pregnancy. They also have an effect on brain chemicals, such as serotonin and dopamine, which affect mood and pain perception. When hormone levels fluctuate, such as during menstruation, pregnancy, or menopause, they can destabilize the pathways in the brain, causing migraines.

According to Dr. Shivananda Pai, Consultant Neurology, migraines are more than a neurological disorder. "Migraines represent a complex interplay of genetic, environmental, and hormonal factors. In women, hormonal fluctuations are a critical trigger that amplifies sensitivity to pain," he explains. Hormonal headaches are particularly challenging because they are influenced by multiple life stages, from puberty to post-menopause. Common causes include:

• Menstrual periods: Estrogen levels significantly drop just before menstruation often triggers a migraine.
• Pregnancy: Hormones can act to relieve symptoms or aggravate them during different times of pregnancy.
• Menopause: The hormonal fluctuation during menopause can intensify a migraine, while some women tend to find relief.
• Hormonal therapies: Birth control and HRT tend to level off hormone balances in some individuals but will exacerbate a migraine in others.

Complex Role of Hormones in Women’s Neurological Health

Estrogen and Neurological Health

Estrogen, often called the "hormone of femininity", does more than regulate reproductive functions. It is a powerful influencer of brain health. Estrogen modulates the activity of neurotransmitters like serotonin, which regulates mood and pain perception, and dopamine, associated with reward and pleasure.

During stages of hormonal stability, like in pregnancy's latter months, women may have fewer migraines because of the steady elevation of estrogen. However, a sudden downfall in estrogen destabilizes these chemicals in the brain, sending a heightened sensitivity for migraine triggers.

Menstrual Migraines

The most common form of hormonal migraines is menstrual migraines, which occur in response to the steep decline in estrogen levels just before menstruation. These are typically more intense and less responsive to standard treatment. The timing of these migraines provides clear evidence of the role hormones play in neurological health.

Pregnancy and Hormonal Shifts

Pregnancy is a rollercoaster of hormones. Although many women experience relief from migraines as a result of the constantly elevated levels of estrogen, some women, particularly in the first trimester, worsen. This individual variability is a characteristic of hormonal migraine triggers.

Hormonal Therapies and Management of Migraine

Hormonal treatments, such as oral contraceptives and HRT, have had mixed reviews regarding their use in managing migraine. Some women fare better with the stabilization the treatment provides, whereas others suffer worsening symptoms. This will depend on the nature and dose of the hormones used.

Post-Menopause: Migraine Remission or Continued Struggles?

For most women, menopause brings relief from their migraines. The decline in frequency and severity often accompanies stability in hormone levels. Even so, the susceptibility remains with some towards other forms of triggers including stress and sleep deprivation, not to forget diet-related factors and continues the saga of migraines well after the menopausal stages.

Effect on Neurological Health Due to Hormonal Changes

The relationship of hormones to neurological health goes beyond migraines. Hormonal changes have profound effects on a woman's brain in general.

Mood Disorders: Estrogen helps stabilize mood by regulating serotonin. Its decline at menopause increases the risk of mood swings and depression.

Neurodegenerative Diseases: Estrogen is neuroprotective, stimulating the growth and repair of brain cells. Its absence in post-menopausal women has been associated with an increased risk of Alzheimer's disease and cognitive decline.

Multiple Sclerosis (MS): Hormonal cycles may affect the course of MS, a disease that occurs more frequently in women than in men. Estrogen's anti-inflammatory effects provide transient protection during pregnancy, reducing relapse rates in women with MS.

"The intricate interplay between hormones and neurological health underscores the need for gender-specific treatment approaches," says Dr. Pai.

Managing Hormonal Migraines: Practical Strategies

While hormonal changes are inevitable, several strategies can help manage migraines effectively:

1. Tracking Your Cycle

Understanding your menstrual cycle can help identify patterns and predict when migraines might occur. This knowledge allows for preventive measures, such as scheduling medications or adjusting lifestyle habits.

2. Consulting Specialists

Working with a neurologist or gynecologist can help develop a personalized treatment plan. Options might include hormonal therapies, triptans, or preventive medications tailored to your specific needs.

3. Adopting a Healthy Lifestyle

A well-balanced diet, regular exercise, and stress management are all integral parts of managing migraines. For instance, magnesium-rich foods and hydration can help reduce the frequency and severity of attacks.

4. Exploring Preventive Therapies

For people with severe or frequent migraines, preventive medications, such as beta-blockers or CGRP inhibitors, may be prescribed. These medications stabilize brain activity and therefore reduce the chances of migraine during hormonal fluctuations.

5. Mind-Body Techniques

Techniques like yoga, meditation, and biofeedback can enhance wellness and reduce the debilitating effects of stress-one of the most common migraine triggers.

Research that was once in its embryonic stage continues to shed more light on the role of hormones in migraines and other neurological conditions. Further breakthroughs in genetic testing might enable doctors to predict, at least in a way, how an individual would react to hormonal therapies. The importance of gender-specific approaches is gradually being realized, which involves differentiating between the plight of women with migraines from others.

As Dr. Pai puts it, "Empowering women with knowledge about the hormonal underpinnings of migraines can lead to better, more personalized care. With the right strategies, migraines can be effectively managed, allowing women to lead fuller, healthier lives.

Migraines are not headaches; they are a complex neurological condition that deeply impacts the lives of millions of women. Understanding the role of hormones in triggering and exacerbating migraines is a vital step toward better management and relief.

Awareness, proactive care, and advances in medical research can help women regain their lives from the grip of hormonal migraines. Whether tracking cycles, adopting healthier habits, or seeking tailored medical care, every step taken toward understanding and managing migraines is a step toward empowerment.

Dr Shivananda Pai is a Consultant Neurology at KMC Hospital Dr B R Ambedkar Circle in Mangalore, India.

Brandes JL. The Influence of Estrogen on Migraine: A Systematic Review. JAMA. 2006;295(15):1824–1830. doi:10.1001/jama.295.15.1824

Sacco S, Ricci S, Degan D, Carolei A. Migraine in women: the role of hormones and their impact on vascular diseases. J Headache Pain. 2012 Apr;13(3):177-89. doi: 10.1007/s10194-012-0424-y. Epub 2012 Feb 26. PMID: 22367631; PMCID: PMC3311830.

For years, moderate alcohol consumption, particularly a daily glass of wine, has been associated with potential health benefits, especially for heart health. However, in recent years, a growing body of research, including warnings from the World Health Organization (WHO) and other health agencies, has highlighted that alcohol poses significant health risks from the very first drink.

A recent expert review published in the Journal of Hepatology reiterated this concern, concluding that there is no universally safe level of alcohol consumption.

No Universal Safe Threshold

After examining recent evidence on alcohol use and health outcomes, researchers from the University of Wisconsin concluded that excessive alcohol consumption is unquestionably harmful and that defining a universally "safe" level of drinking remains unsupported by current scientific evidence.

According to the authors, the health risks associated with alcohol vary considerably from person to person. Factors such as age, sex, genetics, underlying medical conditions, medications, and pregnancy status can all influence how alcohol affects an individual's health.

Rethinking The "Heart Health" Narrative

Also read: 844 Million Adults Worldwide Living With Chronic Kidney Disease: Lancet Study

The researchers also questioned the long-standing belief that moderate drinking provides significant cardiovascular benefits.

They found that recent evidence does not support recommending regular alcohol consumption for health purposes. Instead, the review suggests that any potential benefits must be weighed against known risks, including cancer, liver disease, and other alcohol-related harms.

Alcohol Linked To 62 Disorders

The review adds to a growing body of evidence linking alcohol consumption to an increased risk of several cancers.

A May 2026 study linked alcohol to 62 disorders, ranging from heart and digestive diseases to mental and neurological conditions and cancers.

The study, published in the journal Addiction, showed that the fully alcohol-attributable conditions are mainly grouped under non-communicable diseases and injuries.

These include:

• Endocrine, nutritional, and metabolic diseases
• Mental and behavioral disorders
• Diseases of the nervous system
• Diseases of the circulatory system, such as alcoholic cardiomyopathy
• Digestive diseases
• Alcoholic liver disease and cirrhosis

The data also included psychotic disorders, gastritis, ulcers, pancreatitis, fatty liver disease, pregnancy- and perinatal-related conditions such as fetal alcohol syndrome and fetal alcohol spectrum disorders, as well as external causes and injuries, including alcohol poisoning.

"These conditions are 100 per cent alcohol attributable, meaning these diseases would not even exist in the world without alcohol use," said Jürgen Rehm, senior scientist at the Institute for Mental Health Policy Research in Toronto and part of the study team, according to CNN.

"There are another 30 diseases in which alcohol plays a role, such as breast and other cancers, heart disease, stroke, diabetes, and dementia," Rehm said. "These diseases would exist even without alcohol use, but alcohol use is responsible for a certain proportion of them."

Global Burden Remains High

The global burden of alcohol-related health issues is immense. The US National Institutes of Health (NIH) estimated that alcohol-related conditions could cost the United States nearly $1.87 trillion between 2011 and 2050, equivalent to about 1.45 per cent of the country's GDP. The NIH also criticized the lack of clear public messaging, which has allowed myths about alcohol's safety to persist for decades.

In 2023, the World Health Organization reinforced this warning. In a statement published in The Lancet Public Health, it declared that there is no safe level of alcohol consumption that does not affect health.

While GLP-1 drugs have shown their effectiveness in reducing weight and managing diabetes, new research suggests they may also help reduce the risk of cancer, particularly breast cancer.

According to a new study by researchers from the University of Pennsylvania, US, women between the ages of 45 and 80 who took a GLP-1 medication were 30 per cent less likely to develop breast cancer. The analysis was based on data from more than 110,000 women.

"While the study does not definitively confirm an association between GLP-1 medications and reduced breast cancer incidence, it does add to the growing body of evidence suggesting that it's worth investigating these weight-loss drugs as potential cancer prevention tools," the researchers said.

"GLP-1 medications are intriguing from a cancer research perspective because they weren't designed for cancer therapy, but they do affect many different targets and pathways associated with cancer development, so we're eager to study them in this context," said Elizabeth McDonald, Professor of Radiology at the University of Pennsylvania's Perelman School of Medicine.

The findings were presented at the 2026 American Society of Clinical Oncology (ASCO) Annual Meeting in Chicago and were also published in JCO Oncology Practice.

Potential New Tool For Cancer Prevention

Breast cancer is the leading cause of cancer mortality among women worldwide and the most common cancer diagnosed overall, accounting for approximately 2.3 million new cases and 670,000 deaths annually, according to the World Health Organization. Every year, breast cancer accounts for about 30% of all new cancer cases in US women.

Beyond breast cancer screening through mammography or MRI, medical or surgical interventions to reduce breast cancer risk remain limited and can be life-altering.

Prophylactic mastectomy is recommended for some individuals with genetic mutations that significantly increase their lifetime risk of breast cancer. Tamoxifen is also highly effective in reducing breast cancer incidence among high-risk patients, but its uptake remains limited because of known side effects. In contrast, GLP-1 medications are already widely used by millions of Americans.

"Ultimately, we want to find better options to prevent breast cancer," McDonald said. "It's been encouraging to see the survival rates for breast cancer improve over recent decades, and we'd love to see the same gains in prevention."

GLP-1 Shows Promise For Multiple Cancers

Another study by researchers at the Cleveland Clinic suggested that glucagon-like peptide-1 (GLP-1) medications may help slow the spread of several obesity-related cancers, including lung, breast, colorectal and liver cancers.

The researchers found that across six of the seven malignancies studied, GLP-1 receptor agonist exposure was associated with reduced metastatic progression, with significant reductions observed in non-small cell lung cancer, breast cancer, colorectal cancer and hepatocellular carcinoma.

The study included 12,112 patients with obesity-related cancers ranging from stage 1 to stage 3. Half of the participants began taking a GLP-1 medication after their cancer diagnosis, while the remaining participants were treated with DPP-4 inhibitors, commonly known as "gliptins", a different class of diabetes medications.

The comparison showed that patients who took GLP-1 medications had a substantially lower progression to stage 4 disease across four cancer types.

"Our study found that use of GLP-1 drugs, compared to DPP-4 inhibitors and other antidiabetic drugs, was associated with a meaningful reduction in cancer progression across four solid tumor types," said study author Mark David Orland from the Taussig Cancer Institute at Cleveland Clinic.

Breast Cancer Symptoms

Recognizing the signs and symptoms of breast cancer can help ensure a prompt diagnosis. Breast cancer can cause a wide array of symptoms, including:

• Pain in the breast
• A lump or thickening of tissue in the breast or underarm
• An unexplained change in the size or shape of the breast
• Suddenly asymmetrical breasts
• Irritation in the breast skin
• Redness or warmth in the breast skin
• A change in the texture of the breast skin (often featuring a thick, pitted appearance resembling an orange peel).

Summer vacations are ongoing, and at a time when heatwaves are at its worse, it is no wonder that most children and teens would prefer staying indoors. And for those who spend hours on video games, a psychologist has answered FAQs for parents. If you are concerned about the possibility of gaming addiction in your children, a senior psychologist lists symptoms and simple techniques to help parents deal with it better.

Neha Cadabams, Senior Psychologist and Executive Director at Cadabams Hospitals, in an interview with Health and Me, answered FAQs about the consequences of gaming addiction in children.

Parents often struggle to differentiate between normal gaming enthusiasm and problematic gaming behaviour. What are some of the earliest psychological warning signs that gaming may be becoming an unhealthy emotional dependency rather than just a hobby?

The difference usually becomes visible not through the number of hours spent gaming, but through the emotional role gaming begins to play in the child’s life. Gaming starts becoming concerning when it shifts from being recreational to becoming the primary way a child regulates emotions, avoids distress, or experiences self-worth.

Some of the earliest warning signs are emotional withdrawal from offline life, irritability or emotional outbursts when unable to game, noticeable sleep disruption, declining interest in activities they previously enjoyed, and increasing dependence on in-game achievements for confidence or validation. Parents may also notice that the child appears emotionally disengaged outside gaming environments or struggles to tolerate boredom, stress, or disappointment without returning to gaming immediately.

What is important to understand is that many children using gaming as an emotional coping mechanism continue functioning normally in school or daily routines initially, which is why the issue is often recognised late.

You mentioned that gaming often becomes an “escape hatch” for painful emotions. What are some of the deeper emotional or psychological struggles children may be trying to escape from through excessive gaming?

In many cases, excessive gaming is less about the game itself and more about what the virtual environment provides psychologically. For some children, gaming offers predictability, achievement, social acceptance, control, or emotional relief that they may not be experiencing consistently in real life.

The underlying emotional struggles can vary significantly. We commonly see children using gaming to cope with loneliness, social anxiety, bullying, academic pressure, low self-esteem, family conflict, emotional neglect, or feelings of inadequacy. For some adolescents, gaming becomes a space where they feel competent, valued, or emotionally safer than they do offline.

What makes this particularly concerning is that the emotional distress itself often remains hidden because the gaming behaviour becomes the visible focus. Families may attempt to reduce screen time without recognising the deeper emotional need the child is trying to fulfil through gaming.

Many teenagers who are struggling emotionally continue to perform normally in academics and daily life. Why is emotional distress among adolescents becoming harder for families to recognise today?

One of the biggest shifts we are seeing today is that emotional distress in adolescents no longer always appears as an obvious emotional breakdown or visible dysfunction. Many young people have become highly functional externally while internally struggling with anxiety, loneliness, emotional exhaustion, or low self-worth.

Adolescents today are also under constant pressure to remain socially connected, emotionally composed, and academically competitive. As a result, many learn to internalise distress rather than express it openly. Parents often expect mental health concerns to appear dramatically, but in reality, the early signs are usually subtle behavioural shifts such as emotional withdrawal, irritability, sleep changes, reduced communication, loss of interest in offline activities, or increasing emotional dependence on digital spaces.

Gaming can sometimes become one of the places where this hidden emotional life quietly reveals itself.

What are some common misconceptions parents have about gaming addiction and mental health?

One of the most common misconceptions is that gaming addiction is simply a discipline problem or a result of poor parenting. In reality, problematic gaming behaviour is often deeply connected to emotional coping, psychological vulnerability, and unmet emotional needs.

Another misconception is that all heavy gaming automatically indicates addiction. Many children and young adults engage deeply with gaming recreationally without it interfering with their emotional health or daily functioning. The concern begins when gaming starts replacing emotional coping, relationships, sleep, education, or the ability to function comfortably offline.

Parents also often focus only on restricting access to games without understanding why the child feels emotionally drawn toward gaming so strongly in the first place. Without addressing the underlying emotional factors, simply removing the game can sometimes intensify distress rather than resolve it.

With gaming becoming a massive part of youth culture in India, how can parents build healthier digital habits at home without making children feel controlled or misunderstood?

The starting point should not be surveillance or punishment, but emotional understanding and communication. Children are far more likely to engage positively with boundaries when they feel emotionally understood rather than judged.

Parents should focus on creating balance rather than framing gaming itself as the enemy. This includes encouraging offline activities, improving emotional conversations within the family, maintaining healthy sleep routines, and helping children build confidence and connection outside digital environments.

It is also important for parents to observe the emotional patterns around gaming rather than only the duration. How does the child behave when they are not gaming? Are they able to emotionally regulate offline? Are they socially connected outside virtual environments? Are they using gaming occasionally for enjoyment, or consistently to avoid discomfort, stress, or emotional pain?