For those who have not experienced a migraine, perhaps it would seem just another headache. But for someone like me who has suffered through migraines that will last over a week even with medication, I can definitely tell you that it's much more. The ache is not confined to the head; it's the whole experience. Nausea, sensitivity to light, and throbs so bad it makes simple tasks unbearable. It also comes with an emotional burden—the loneliness and frustration are pretty unbearable. Through the years, realizing how hormones are also implicated in triggering and exacerbating my migraines has helped change the game in my dealing with these episodes.

What are Hormonal Migraines?

Hormonal migraines are caused by fluctuations in estrogen and progesterone, the two main female hormones. These hormones are essential for the reproductive system, regulating menstrual cycles and pregnancy. They also have an effect on brain chemicals, such as serotonin and dopamine, which affect mood and pain perception. When hormone levels fluctuate, such as during menstruation, pregnancy, or menopause, they can destabilize the pathways in the brain, causing migraines.

According to Dr. Shivananda Pai, Consultant Neurology, migraines are more than a neurological disorder. "Migraines represent a complex interplay of genetic, environmental, and hormonal factors. In women, hormonal fluctuations are a critical trigger that amplifies sensitivity to pain," he explains. Hormonal headaches are particularly challenging because they are influenced by multiple life stages, from puberty to post-menopause. Common causes include:

• Menstrual periods: Estrogen levels significantly drop just before menstruation often triggers a migraine.
• Pregnancy: Hormones can act to relieve symptoms or aggravate them during different times of pregnancy.
• Menopause: The hormonal fluctuation during menopause can intensify a migraine, while some women tend to find relief.
• Hormonal therapies: Birth control and HRT tend to level off hormone balances in some individuals but will exacerbate a migraine in others.

Complex Role of Hormones in Women’s Neurological Health

Estrogen and Neurological Health

Estrogen, often called the "hormone of femininity", does more than regulate reproductive functions. It is a powerful influencer of brain health. Estrogen modulates the activity of neurotransmitters like serotonin, which regulates mood and pain perception, and dopamine, associated with reward and pleasure.

During stages of hormonal stability, like in pregnancy's latter months, women may have fewer migraines because of the steady elevation of estrogen. However, a sudden downfall in estrogen destabilizes these chemicals in the brain, sending a heightened sensitivity for migraine triggers.

Menstrual Migraines

The most common form of hormonal migraines is menstrual migraines, which occur in response to the steep decline in estrogen levels just before menstruation. These are typically more intense and less responsive to standard treatment. The timing of these migraines provides clear evidence of the role hormones play in neurological health.

Pregnancy and Hormonal Shifts

Pregnancy is a rollercoaster of hormones. Although many women experience relief from migraines as a result of the constantly elevated levels of estrogen, some women, particularly in the first trimester, worsen. This individual variability is a characteristic of hormonal migraine triggers.

Hormonal Therapies and Management of Migraine

Hormonal treatments, such as oral contraceptives and HRT, have had mixed reviews regarding their use in managing migraine. Some women fare better with the stabilization the treatment provides, whereas others suffer worsening symptoms. This will depend on the nature and dose of the hormones used.

Post-Menopause: Migraine Remission or Continued Struggles?

For most women, menopause brings relief from their migraines. The decline in frequency and severity often accompanies stability in hormone levels. Even so, the susceptibility remains with some towards other forms of triggers including stress and sleep deprivation, not to forget diet-related factors and continues the saga of migraines well after the menopausal stages.

Effect on Neurological Health Due to Hormonal Changes

The relationship of hormones to neurological health goes beyond migraines. Hormonal changes have profound effects on a woman's brain in general.

Mood Disorders: Estrogen helps stabilize mood by regulating serotonin. Its decline at menopause increases the risk of mood swings and depression.

Neurodegenerative Diseases: Estrogen is neuroprotective, stimulating the growth and repair of brain cells. Its absence in post-menopausal women has been associated with an increased risk of Alzheimer's disease and cognitive decline.

Multiple Sclerosis (MS): Hormonal cycles may affect the course of MS, a disease that occurs more frequently in women than in men. Estrogen's anti-inflammatory effects provide transient protection during pregnancy, reducing relapse rates in women with MS.

"The intricate interplay between hormones and neurological health underscores the need for gender-specific treatment approaches," says Dr. Pai.

Managing Hormonal Migraines: Practical Strategies

While hormonal changes are inevitable, several strategies can help manage migraines effectively:

1. Tracking Your Cycle

Understanding your menstrual cycle can help identify patterns and predict when migraines might occur. This knowledge allows for preventive measures, such as scheduling medications or adjusting lifestyle habits.

2. Consulting Specialists

Working with a neurologist or gynecologist can help develop a personalized treatment plan. Options might include hormonal therapies, triptans, or preventive medications tailored to your specific needs.

3. Adopting a Healthy Lifestyle

A well-balanced diet, regular exercise, and stress management are all integral parts of managing migraines. For instance, magnesium-rich foods and hydration can help reduce the frequency and severity of attacks.

4. Exploring Preventive Therapies

For people with severe or frequent migraines, preventive medications, such as beta-blockers or CGRP inhibitors, may be prescribed. These medications stabilize brain activity and therefore reduce the chances of migraine during hormonal fluctuations.

5. Mind-Body Techniques

Techniques like yoga, meditation, and biofeedback can enhance wellness and reduce the debilitating effects of stress-one of the most common migraine triggers.

Research that was once in its embryonic stage continues to shed more light on the role of hormones in migraines and other neurological conditions. Further breakthroughs in genetic testing might enable doctors to predict, at least in a way, how an individual would react to hormonal therapies. The importance of gender-specific approaches is gradually being realized, which involves differentiating between the plight of women with migraines from others.

As Dr. Pai puts it, "Empowering women with knowledge about the hormonal underpinnings of migraines can lead to better, more personalized care. With the right strategies, migraines can be effectively managed, allowing women to lead fuller, healthier lives.

Migraines are not headaches; they are a complex neurological condition that deeply impacts the lives of millions of women. Understanding the role of hormones in triggering and exacerbating migraines is a vital step toward better management and relief.

Awareness, proactive care, and advances in medical research can help women regain their lives from the grip of hormonal migraines. Whether tracking cycles, adopting healthier habits, or seeking tailored medical care, every step taken toward understanding and managing migraines is a step toward empowerment.

Dr Shivananda Pai is a Consultant Neurology at KMC Hospital Dr B R Ambedkar Circle in Mangalore, India.

Brandes JL. The Influence of Estrogen on Migraine: A Systematic Review. JAMA. 2006;295(15):1824–1830. doi:10.1001/jama.295.15.1824

Sacco S, Ricci S, Degan D, Carolei A. Migraine in women: the role of hormones and their impact on vascular diseases. J Headache Pain. 2012 Apr;13(3):177-89. doi: 10.1007/s10194-012-0424-y. Epub 2012 Feb 26. PMID: 22367631; PMCID: PMC3311830.

Diwali is traditionally associated with celebrations, family gatherings, illuminated homes and the sound of festivities. However, for women who are pregnant, the festive season can bring an additional health concern that often goes unnoticed: deteriorating air quality. The combination of firecracker emissions, vehicular pollution, construction dust and seasonal changes can significantly increase the concentration of pollutants in the air, making it particularly important for expectant mothers to be mindful of their surroundings.

Pregnancy is a period of considerable physiological and developmental change. A woman's respiratory and cardiovascular systems undergo adaptations to support the growing baby, and exposure to pollutants such as fine particulate matter (PM2.5) can add to the body's environmental burden. These particles are small enough to penetrate deep into the lungs and trigger inflammatory responses. Research has associated maternal exposure to air pollution with adverse pregnancy outcomes, including preterm birth, low birth weight and babies being small for their gestational age.

However, this does not mean pregnant women need to withdraw completely from festive celebrations. The objective should be to make informed choices, reduce unnecessary exposure and understand how precautions can be adapted at different stages of pregnancy.

First Trimester: Prioritising Early Development and Reducing Exposure

The first trimester, particularly the initial 12 weeks, is a critical period of embryonic development, when major organs and body systems begin forming. During this stage, expectant mothers may also experience nausea, fatigue, dizziness and increased sensitivity to certain environmental triggers.

Exposure to firecracker smoke and heavily polluted environments should be minimised. Although an isolated exposure does not automatically indicate harm to the pregnancy, repeated or prolonged exposure to poor air quality is best avoided.

Women in their first trimester should consider the following precautions:

- Avoid standing near areas where firecrackers are being burst or smoke is accumulating. Even brief festive activities can result in unnecessary exposure when pollution levels are high.

- Check the local Air Quality Index (AQI) before stepping outdoors. Reschedule non-essential outdoor activities when air quality deteriorates.

- Avoid participating in activities involving firecracker lighting, including sparklers and other fireworks.

- Keep indoor environments as clean as possible by avoiding excessive incense, dhoop and other smoke-producing substances.

- Maintain adequate hydration, eat balanced meals and prioritise rest, particularly if experiencing pregnancy-related fatigue or nausea.

The first trimester is also when women should be particularly mindful of their overall health rather than attempting to maintain their usual festive routines at the cost of adequate rest.

Also read: Delhi Becomes World's Most Polluted City Ahead Of Diwali, Says Swiss Agency: Experts Recommend Precautions

Second Trimester: Balancing Mobility, Physical Activity and Environmental Safety

The second trimester is often considered a relatively comfortable phase of pregnancy. Many women experience a reduction in early pregnancy symptoms and may feel more energetic, making social gatherings and festive activities easier to manage.

However, feeling physically better should not translate into overlooking environmental risks. Continued exposure to fine particulate matter and other pollutants can affect maternal respiratory health and has been associated with adverse fetal growth outcomes.

A few practical adjustments can help women enjoy the festivities without unnecessary exposure.

- Choose indoor celebrations or smaller family gatherings instead of crowded outdoor events, especially in areas with visible smoke.

- Avoid evening walks or outdoor exercise when AQI levels are poor. Physical exertion can increase the volume of air inhaled, potentially increasing pollutant exposure.

- If outdoor movement is unavoidable, a properly fitted N95 mask may help reduce exposure to particulate matter. However, it does not eliminate all pollutants or replace the need to avoid heavily polluted environments.

- Keep windows closed during periods when outdoor pollution is particularly high. Ventilate the house when outdoor air quality improves.

- Continue pregnancy-appropriate physical activity as advised by the treating obstetrician, adapting the routine according to local air quality conditions.

Women should also avoid prolonged standing, excessive physical exertion and crowded spaces where access to clean air may be limited.

Also read: Can Prolonged Exposure To PM2.5 Increase The Risk Of Blood Clots And Stroke?

Third Trimester: Protecting Maternal Respiratory Health and Avoiding Physical Strain

During the third trimester, the growing uterus places additional pressure on the diaphragm, and many women experience breathlessness, fatigue, disturbed sleep and reduced physical mobility.

When these changes coincide with poor air quality, the importance of limiting exposure becomes even more relevant. Maternal exposure to air pollution has been associated with an increased likelihood of preterm birth and low birth weight, although these outcomes are influenced by several factors and cannot be attributed to a single exposure.

At this stage, the focus should be on maintaining comfort, avoiding unnecessary physical strain and ensuring timely medical attention when required.

Expectant mothers in their third trimester should:

- Avoid crowded firecracker celebrations, open-air events and prolonged exposure to smoke.

- Prefer celebrations at home or in well-ventilated indoor environments with cleaner air.

- Avoid lifting heavy decorations, climbing ladders or undertaking physically demanding festive preparations.

- Keep antenatal appointments on schedule and discuss any respiratory discomfort or concerns about pollution exposure with their obstetrician.

- Avoid unnecessary late-night outings, particularly when pollution levels tend to remain elevated.

Women experiencing persistent breathlessness, chest discomfort, wheezing or unusual fatigue should not dismiss these symptoms as routine pregnancy-related discomfort.

Beyond the Trimester: Five Air-Safety Habits Every Expectant Mother Should Follow

While pregnancy progresses through different developmental stages, the need to minimise pollution exposure remains consistent throughout all three trimesters. A few simple measures can make festive celebrations safer.

1. Make AQI checks part of your daily routine

Do not rely solely on visible smoke or haze to judge air quality. Check the local AQI through official monitoring platforms such as the Central Pollution Control Board before planning outdoor activities. Pollution levels can vary considerably between neighbourhoods and throughout the day.

2. Keep indoor air cleaner

Indoor spaces are not automatically pollution-free. Smoke from incense sticks, camphor, candles and firecrackers entering through open windows can affect indoor air quality. Avoid unnecessary smoke-producing activities and consider using a properly sized HEPA air purifier, if available.

3. Choose celebrations that do not involve firecrackers

Lighting diyas, decorating the home, preparing festive meals and spending time with family are meaningful ways to celebrate without adding to firecracker-related pollution. Staying away from areas where fireworks are being burst is particularly important.

4. Do not compromise on hydration and nutrition

A balanced diet containing seasonal fruits, vegetables and adequate protein supports maternal health. Drinking sufficient water helps maintain hydration, although neither hydration nor antioxidant-rich foods can neutralise the effects of inhaled pollutants.

5. Know when to seek medical attention

Persistent coughing, wheezing, chest pain, significant breathlessness, dizziness or other unusual symptoms warrant medical evaluation. Pregnant women with asthma or existing respiratory or cardiovascular conditions should discuss an individualised pollution-safety plan with their healthcare provider.

A Healthier Diwali Begins With Informed Choices

One of the biggest misconceptions surrounding pregnancy and pollution is that precautions are necessary only when air quality becomes visibly poor. In reality, exposure to particulate matter can occur even when the air appears relatively clear. This makes awareness and preventive action important throughout the festive period.

It is equally important to remember that pregnancy does not mean putting life on hold. Women can continue to participate in meaningful traditions, enjoy family gatherings and celebrate festivals by making sensible adjustments to their environment and activities.

There is no single trimester in which exposure to air pollution can be considered completely safe, and no precaution can eliminate exposure entirely. The emphasis should be on reducing avoidable exposure, following local air-quality advisories and seeking individualised medical guidance.

Diwali should be a celebration of light, happiness and togetherness. For expectant mothers, a little extra planning can help ensure that the festivities remain centred on what matters most: their health, comfort and the well-being of their growing baby.

By Dr Sudeshna Ray, Associate Director Obstetrician, Gynaecologist, Jaslok Hospital and Research Centre, Sr Consultant in Breach Candy & HN Reliance

You may not smoke, exercise regularly, maintain a healthy weight and have no known medical condition. But could the air you breathe still increase your risk of stroke?

The answer is yes. Air pollution affects more than the lungs; it is associated with cardiovascular disease and stroke. PM2.5 fine particulate matter measuring 2.5 micrometres or less in diameter can penetrate deep into the lungs and trigger biological responses affecting blood vessels throughout the body.

How can polluted air affect the brain?

A stroke occurs when blood flow to part of the brain is interrupted or when a blood vessel ruptures.

PM2.5 exposure may contribute to inflammation, oxidative stress and dysfunction of the endothelium, the inner lining of blood vessels. It may also influence platelet activation and normal blood-clotting mechanisms, potentially favouring thrombosis.

Over time, prolonged exposure may contribute to atherosclerosis, the build-up of plaques inside arteries. If a plaque ruptures and a clot blocks an artery supplying the brain, an ischaemic stroke can occur. Air pollution may also affect blood pressure and cardiovascular function.

However, exposure does not inevitably cause a clot or stroke. It is one of several factors that may influence an individual's risk.

Also read: Breathe Easy This Diwali: Early Warning Signs & Precautions to Protect Children & Senior Citizens

Can apparently healthy people also be affected?

Yes. Having no diagnosed hypertension, diabetes, high cholesterol or heart disease does not eliminate pollution-associated stroke risk.

A systematic review published in the British Medical Journal in 2015 found that a 10 µg/m³ increase in short-term PM2.5 exposure was associated with approximately a 1.1% relative increase in stroke admissions or mortality. This is a population-level association, not an individual's absolute risk or proof of causation in a particular patient.

Who needs particular attention?

Older adults and people with hypertension, diabetes, dyslipidaemia, coronary artery disease, atrial fibrillation or a previous stroke or transient ischaemic attack (TIA) warrant particular attention because their baseline vascular risk is high.

Five practical steps to reduce exposure

• Check the AQI: Monitor air-quality readings, particularly during periods of severe pollution.
• Modify outdoor activity: Reduce prolonged or strenuous exercise when air quality is poor; choose cleaner environments or indoor exercise.
• Use appropriate protection: A well-fitting N95 mask can reduce inhalation of fine particles when outdoor exposure is unavoidable.
• Improve indoor air: Consider appropriately sized HEPA filtration and minimise tobacco smoke and other combustion-related pollution.
• Manage vascular risk: Monitor blood pressure, glucose and cholesterol when appropriate, and follow prescribed treatment.

Do not start aspirin or anticoagulants solely because pollution levels are high. These medicines carry risks and should be used only when clinically indicated under medical supervision.

Individual precautions help, but sustained improvements require cleaner transport, effective industrial emission controls and prevention of waste burning.

Stroke prevention must address established medical risk factors as well as avoidable environmental exposures. The air may look clear, but that does not guarantee it is clean. Protecting the air, we breathe is also an investment in the health of our brains.

By Dr. Ashish Susvirkar, Senior Neurologist and Movement Disorders Specialist, Bhailal Amin General Hospital, Vadodara

Patient developed severe malaria affecting his platelets, liver, kidneys and lungs, with the lung injury progressing to Acute Respiratory Distress Syndrome (ARDS) and requiring ventilator support.

A 45-year-old motorman developed life-threatening complications after malaria progressed to multi-organ failure, affecting his lungs, liver and kidneys and causing a significant drop in platelet count and blood pressure.

His lung function deteriorated severely, leading to Acute Respiratory Distress Syndrome (ARDS), a serious condition in which the lungs are unable to provide enough oxygen to the body. He required ventilator support with high levels of oxygen and pressure to help him breathe.

Malaria Progresses To Multi-Organ Failure

The patient was admitted in a severely ill condition after being diagnosed with malaria. By the time he reached the hospital, the infection had affected multiple organ systems.

His platelet count was low, while his liver and kidneys were affected. The most critical complication was severe lung involvement. The patient developed ARDS, resulting in significant difficulty in maintaining adequate oxygen levels and requiring mechanical ventilation. His blood pressure had also dropped significantly, necessitating medicines to support his circulation.

Also read: NHS Data Shows 12% Increase In Kidney Cancer In People Under 50: Experts Flag Overlooked Signs

Severe Lung Injury Requires Ventilator Support

Malaria can sometimes become severe and affect multiple organs. In this patient, the lungs were particularly badly affected and he developed Acute Respiratory Distress Syndrome, or ARDS.

In ARDS, the lungs become severely inflamed and are unable to transfer sufficient oxygen into the bloodstream. He therefore required ventilator support, including higher oxygen and controlled pressure to help maintain adequate oxygenation. At the same time, we had to support his blood pressure and closely monitor his liver and kidney function.

Intensive Treatment Helps Patient Recover Without Dialysis

The patient was treated with appropriate anti-malarial therapy along with intensive supportive care. He was placed on ventilator support because of severe respiratory failure and was given medicines to maintain his blood pressure. His fluid status was carefully managed, while his urine output and kidney function were closely monitored.

Despite the initial kidney involvement, his urine output gradually improved and he did not require dialysis. Over the next several days, his lung function also began to improve. As his oxygenation and overall condition stabilised, the medical team was able to gradually reduce the level of ventilator support and eventually take him off the ventilator.

After approximately 7–8 days of intensive treatment and monitoring, the patient showed significant clinical improvement. He was successfully weaned off ventilator support, regained his strength and was able to walk before being discharged from the hospital.

The patient came in a very critical condition, with the lungs, liver and kidneys affected and blood pressure requiring support. The first few days were particularly important because we had to support several organ systems simultaneously while treating the malaria. His urine output improved without the need for dialysis, and his respiratory status gradually recovered. Within about a week, he was off the ventilator and eventually walked home.

When Can Malaria Become Life-Threatening?

The case highlights that malaria can, in some patients, progress beyond fever and routine symptoms and cause severe complications involving multiple organs. Lung involvement can be particularly serious, and conditions such as ARDS may require prolonged respiratory support in an intensive care setting.

Doctors advise people with malaria to seek timely medical attention, particularly if fever is accompanied by breathing difficulty, reduced urine output, unusual drowsiness, persistent vomiting, bleeding, severe weakness or low blood pressure. Early recognition of complications and appropriate supportive care can be critical in preventing further deterioration.