For those who have not experienced a migraine, perhaps it would seem just another headache. But for someone like me who has suffered through migraines that will last over a week even with medication, I can definitely tell you that it's much more. The ache is not confined to the head; it's the whole experience. Nausea, sensitivity to light, and throbs so bad it makes simple tasks unbearable. It also comes with an emotional burden—the loneliness and frustration are pretty unbearable. Through the years, realizing how hormones are also implicated in triggering and exacerbating my migraines has helped change the game in my dealing with these episodes.

What are Hormonal Migraines?

Hormonal migraines are caused by fluctuations in estrogen and progesterone, the two main female hormones. These hormones are essential for the reproductive system, regulating menstrual cycles and pregnancy. They also have an effect on brain chemicals, such as serotonin and dopamine, which affect mood and pain perception. When hormone levels fluctuate, such as during menstruation, pregnancy, or menopause, they can destabilize the pathways in the brain, causing migraines.

According to Dr. Shivananda Pai, Consultant Neurology, migraines are more than a neurological disorder. "Migraines represent a complex interplay of genetic, environmental, and hormonal factors. In women, hormonal fluctuations are a critical trigger that amplifies sensitivity to pain," he explains. Hormonal headaches are particularly challenging because they are influenced by multiple life stages, from puberty to post-menopause. Common causes include:

• Menstrual periods: Estrogen levels significantly drop just before menstruation often triggers a migraine.
• Pregnancy: Hormones can act to relieve symptoms or aggravate them during different times of pregnancy.
• Menopause: The hormonal fluctuation during menopause can intensify a migraine, while some women tend to find relief.
• Hormonal therapies: Birth control and HRT tend to level off hormone balances in some individuals but will exacerbate a migraine in others.

Complex Role of Hormones in Women’s Neurological Health

Estrogen and Neurological Health

Estrogen, often called the "hormone of femininity", does more than regulate reproductive functions. It is a powerful influencer of brain health. Estrogen modulates the activity of neurotransmitters like serotonin, which regulates mood and pain perception, and dopamine, associated with reward and pleasure.

During stages of hormonal stability, like in pregnancy's latter months, women may have fewer migraines because of the steady elevation of estrogen. However, a sudden downfall in estrogen destabilizes these chemicals in the brain, sending a heightened sensitivity for migraine triggers.

Menstrual Migraines

The most common form of hormonal migraines is menstrual migraines, which occur in response to the steep decline in estrogen levels just before menstruation. These are typically more intense and less responsive to standard treatment. The timing of these migraines provides clear evidence of the role hormones play in neurological health.

Pregnancy and Hormonal Shifts

Pregnancy is a rollercoaster of hormones. Although many women experience relief from migraines as a result of the constantly elevated levels of estrogen, some women, particularly in the first trimester, worsen. This individual variability is a characteristic of hormonal migraine triggers.

Hormonal Therapies and Management of Migraine

Hormonal treatments, such as oral contraceptives and HRT, have had mixed reviews regarding their use in managing migraine. Some women fare better with the stabilization the treatment provides, whereas others suffer worsening symptoms. This will depend on the nature and dose of the hormones used.

Post-Menopause: Migraine Remission or Continued Struggles?

For most women, menopause brings relief from their migraines. The decline in frequency and severity often accompanies stability in hormone levels. Even so, the susceptibility remains with some towards other forms of triggers including stress and sleep deprivation, not to forget diet-related factors and continues the saga of migraines well after the menopausal stages.

Effect on Neurological Health Due to Hormonal Changes

The relationship of hormones to neurological health goes beyond migraines. Hormonal changes have profound effects on a woman's brain in general.

Mood Disorders: Estrogen helps stabilize mood by regulating serotonin. Its decline at menopause increases the risk of mood swings and depression.

Neurodegenerative Diseases: Estrogen is neuroprotective, stimulating the growth and repair of brain cells. Its absence in post-menopausal women has been associated with an increased risk of Alzheimer's disease and cognitive decline.

Multiple Sclerosis (MS): Hormonal cycles may affect the course of MS, a disease that occurs more frequently in women than in men. Estrogen's anti-inflammatory effects provide transient protection during pregnancy, reducing relapse rates in women with MS.

"The intricate interplay between hormones and neurological health underscores the need for gender-specific treatment approaches," says Dr. Pai.

Managing Hormonal Migraines: Practical Strategies

While hormonal changes are inevitable, several strategies can help manage migraines effectively:

1. Tracking Your Cycle

Understanding your menstrual cycle can help identify patterns and predict when migraines might occur. This knowledge allows for preventive measures, such as scheduling medications or adjusting lifestyle habits.

2. Consulting Specialists

Working with a neurologist or gynecologist can help develop a personalized treatment plan. Options might include hormonal therapies, triptans, or preventive medications tailored to your specific needs.

3. Adopting a Healthy Lifestyle

A well-balanced diet, regular exercise, and stress management are all integral parts of managing migraines. For instance, magnesium-rich foods and hydration can help reduce the frequency and severity of attacks.

4. Exploring Preventive Therapies

For people with severe or frequent migraines, preventive medications, such as beta-blockers or CGRP inhibitors, may be prescribed. These medications stabilize brain activity and therefore reduce the chances of migraine during hormonal fluctuations.

5. Mind-Body Techniques

Techniques like yoga, meditation, and biofeedback can enhance wellness and reduce the debilitating effects of stress-one of the most common migraine triggers.

Research that was once in its embryonic stage continues to shed more light on the role of hormones in migraines and other neurological conditions. Further breakthroughs in genetic testing might enable doctors to predict, at least in a way, how an individual would react to hormonal therapies. The importance of gender-specific approaches is gradually being realized, which involves differentiating between the plight of women with migraines from others.

As Dr. Pai puts it, "Empowering women with knowledge about the hormonal underpinnings of migraines can lead to better, more personalized care. With the right strategies, migraines can be effectively managed, allowing women to lead fuller, healthier lives.

Migraines are not headaches; they are a complex neurological condition that deeply impacts the lives of millions of women. Understanding the role of hormones in triggering and exacerbating migraines is a vital step toward better management and relief.

Awareness, proactive care, and advances in medical research can help women regain their lives from the grip of hormonal migraines. Whether tracking cycles, adopting healthier habits, or seeking tailored medical care, every step taken toward understanding and managing migraines is a step toward empowerment.

Dr Shivananda Pai is a Consultant Neurology at KMC Hospital Dr B R Ambedkar Circle in Mangalore, India.

Brandes JL. The Influence of Estrogen on Migraine: A Systematic Review. JAMA. 2006;295(15):1824–1830. doi:10.1001/jama.295.15.1824

Sacco S, Ricci S, Degan D, Carolei A. Migraine in women: the role of hormones and their impact on vascular diseases. J Headache Pain. 2012 Apr;13(3):177-89. doi: 10.1007/s10194-012-0424-y. Epub 2012 Feb 26. PMID: 22367631; PMCID: PMC3311830.

First wife of singer Udit Narayan, Ranjana Narayan Jha made serious allegations against him, claiming that he forced her to get hysterectomy. She filed a police complaint earlier this week at the Women's Police Station in Supaul district, Bihar.

She accused Udit Narayan and his two brothers Sanjay Kumar Jha and Lalit Narayan Jha and his second wife Deepa Narayan of a criminal conspiracy that lead to hysterectomy - the surgical removal of uterus, without her knowledge. As per an NDTV report, "She claimed she became aware of this only years later during medical treatment."

Udit Narayan's First Wife's Allegations

As per the complaint, Udit and Ranjana were married on December 7, 1984, in a traditional Hindu ceremony. Udit then moved to Mumbai in 1985 to pursue his music career. She later learned through media that he had married another woman Deepa. As per the complaint, he continued to mislead her whenever she confronted him.

As per the complaint, in 1996, she was taken to a hospital in Delhi under the pretext of medical treatment, where, she claims that her uterus was removed without her knowledge. She said that she was compelled to file a complaint years after being ignored. "You all know that Udit Narayan ji repeatedly makes promises but does not fulfill them. He has not done anything till now, which is why I have come to the Women's Police Station. I deserve justice," she said.

"Nowadays, I am constantly unwell and need his support. But Udit Narayan is neither saying anything nor doing anything. He came to the village recently and left after making promises once again," she said, as per a Hindustan Times report.

What Is Hysterectomy?

It is the surgical removal of one's uterus and cervix. There are different kinds of hysterectomy available, which depends on the condition of the patients.

Total Hysterectomy

This removes uterus and cervix, but leaves ovaries. This means the person does not enter menopause after the surgery.

Supracervical Hysterectomy

Removing just the upper part of the uterus and leaving the cervix. This could also be when your fallopian tubes and ovaries are removed at the same time. Since, you have a cervix, you will still need Pap smears.

Total Hysterectomy With Bilateral Salpingo-oophorectomy

This is the removal of uterus, cervix, fallopian tubes and ovaries. This will start menopause immediately after the surgery.

Radical Hysterectomy With Bilateral Salpingo-oophorectomy

This is the removal of uterus, cervix, fallopian tubes, ovaries, the upper portion of your vagina, and some surrounding tissue and lymph nodes. This is done to people with cancer. Patients who get this enter menopause right after the surgery.

Lorna Luxe's Husband, 64, John Andrews passed away after a three-year-long cancer battle. On February 11, the British influencer shared a post on her Instagram. The 43-year-old wrote: "My beautiful, brave John died yesterday. I am heartbroken. We were together to the every end, at home, in our own bed and holding hands which is exactly what he wanted."

Lorna Luxe's Husband John Dies: What Happened To Him?

John, a former banker, was diagnosed with stage three cancer in 2023. He had been receiving treatment over the last three years. John's cancer also entered remission and it returned in 2024 and spread to his brain.

He underwent a surgery in 2025, however, he was back in hospital in December after a complication with his chemotherapy treatments. This led to organ failure.

In January this year, Lorna told her followers that she was "looking for a miracle" and shared that his cancer had "progressed to his other organs" and treatment was "no longer an option".

“I think he's possibly the bravest person. And I suppose at this point we're looking for a bit of a miracle and we're going to take each day as it comes,” she wrote on her post.

In her post that announced John's death, she wrote when she asked him how he was feeling, her husband responded, "Rough, but in love".

Read: Catherine O'Hara Cause Of Death Is Pulmonary Embolism; She Also Had Rectal Cancer

Lorna Luxe's Husband John Dies: Can Cancer Spread To Other Organs?

While John's cancer has not been specified, but the reports reveal that his cancer spread to other organs. According to National Institution of Health (NIH), US, the spreading of cancer to other parts of the body is called metastasis.

This happens when cancer cells break away from where they first formed, and travel through the blood or lymph system. This could lead to formation of new tumors in other parts of the body. Cancer can spread to anywhere in the body, however, it is common for cancer to move into your bones, liver, or lungs.

When these new tumors are found, they are made of the same cells from the original tumor. Which means, if someone has lung cancer and it spread to brain, the cells do not look like brain cancer. This means that the cancer cells in the brain is metastatic lung cancer.

Cancer cells could also be sent to lab to know the origin of the cell. Knowing the type of cancer helps in better treatment plan.

Lorna Luxe's Husband John Dies: Could Chemotherapy Lead To Organ Damage?

As per the University of Rochester Medical Center, in some cases, chemotherapy could cause permanent changes or damage to the heart, lungs, nerves, kidneys, and reproductive organs or other organs.

For instance, some anti-cancer drugs cause bladder irritation, it could result in temporary or permanent damage to kidneys or bladder. In other cases, chemotherapy could also have potential effects on nerves and muscles. Chemotherapy could also damage the chromosomes in the sperm, which could also lead to birth defects. In females, it could damage the ovaries and could result in short-term or long-term fertility issues.

Chemotherapy could also induce menopause before the correct age and could cause symptoms like hot flashes, dry vaginal tissues, sweating, and more.

Read: 'I Went Into Chemo-induced Menopause At 37', Says Lisa Ray About Her Cancer Journey And Its Side Effects

For some, it could also cause a 'chemo-brain', which is a mental fog that many chemotherapy patients face, that could affect memory or concentration.

Actress Bijou Phillips, 45, has turned to social media to seek a kidney, issuing an urgent request. In a recent social media post, the ‘Made for Each Other’ actress issued a heartfelt plea for a living kidney donor to help her navigate a the medical crisis.

Phillips framed her request not just as an actress, but through the lens of her family roles. "I’m asking as a friend, a sister, an aunt and most important, a single mother to an incredible and brave daughter," she said.

Why Does Bijou Phillips Need A Kidney Transplant?

In a post dated February 11, she explained that she was born with underdeveloped kidneys and spent 3 months in the NICU (Neonatal Intensive Care Unit). In 2017 she received her first kidney transplant which helped her for eight years. However, she faced many complications including the BK virus that led to cellular and antibody rejection.

BK virus, according to the National Kidney Foundation, is a common inactive virus in the body that can ‘wake up’ after a transplant.

It can cause blurred vision, change in the color of urine, pain or discomfort while urinating, trouble breathing, fever, muscle pain, frequent urination, as well as seizures.

What Causes Underdeveloped Kidneys?

Different conditions are known to cause either underdeveloped kidneys or the absence of one or both kidneys, Bilateral Renal Agenesis/Hypoplasia/Dysplasia. According to the PLOS One 2010 study, these 3 types of underdeveloped kidneys fall under the Congenital Anomalies of the Kidney and Urinary Tract or CAKUT. However there are a few differences.

Bilateral Renal Agenesis

This occurs when both kidneys fail to develop entirely. The study links this to "gene-free" chromosomal breaks and mutations in the Esrrg gene, which normally directs essential early kidney formation.

Renal Hypoplasia

The kidneys are present but significantly small or "underdeveloped." The research suggests this happens when genetic signals for "ductal tissue" are interrupted, preventing the kidneys from reaching their full, functional size.

Renal Dysplasia

This is an "abnormal" formation where kidney tissue is malformed. The study associates this with "laterality" errors, where the body's internal organization fails, causing kidneys to grow with structural defects.

What Are Signs of Underdeveloped Kidneys?

According to the Children’s Hospital of Philadelphia, kidney and urinary tract issues are usually spotted during a pregnancy ultrasound. When a problem is found, doctors watch the amniotic fluid levels closely, since that fluid is mostly made of the baby’s urine. If the issue isn't caught before birth, you might notice these signs in a baby or child:

• Frequent UTIs
• A swollen stomach
• Puffiness
• Stomach troubles
• Slow growth
• Low energy

Bijou Phillips’ Message For Supporters

Currently back on dialysis, Phillips is under the care of Dr. Anjay Rastogi at UCLA. She is actively searching for a living donor and has directed interested individuals to a screening link in her Instagram bio.

"Please help me find a living donor so that I can have more time with my daughter, family, friends," she wrote, expressing deep gratitude for the public's ongoing support.