For those who have not experienced a migraine, perhaps it would seem just another headache. But for someone like me who has suffered through migraines that will last over a week even with medication, I can definitely tell you that it's much more. The ache is not confined to the head; it's the whole experience. Nausea, sensitivity to light, and throbs so bad it makes simple tasks unbearable. It also comes with an emotional burden—the loneliness and frustration are pretty unbearable. Through the years, realizing how hormones are also implicated in triggering and exacerbating my migraines has helped change the game in my dealing with these episodes.

What are Hormonal Migraines?

Hormonal migraines are caused by fluctuations in estrogen and progesterone, the two main female hormones. These hormones are essential for the reproductive system, regulating menstrual cycles and pregnancy. They also have an effect on brain chemicals, such as serotonin and dopamine, which affect mood and pain perception. When hormone levels fluctuate, such as during menstruation, pregnancy, or menopause, they can destabilize the pathways in the brain, causing migraines.

According to Dr. Shivananda Pai, Consultant Neurology, migraines are more than a neurological disorder. "Migraines represent a complex interplay of genetic, environmental, and hormonal factors. In women, hormonal fluctuations are a critical trigger that amplifies sensitivity to pain," he explains. Hormonal headaches are particularly challenging because they are influenced by multiple life stages, from puberty to post-menopause. Common causes include:

• Menstrual periods: Estrogen levels significantly drop just before menstruation often triggers a migraine.
• Pregnancy: Hormones can act to relieve symptoms or aggravate them during different times of pregnancy.
• Menopause: The hormonal fluctuation during menopause can intensify a migraine, while some women tend to find relief.
• Hormonal therapies: Birth control and HRT tend to level off hormone balances in some individuals but will exacerbate a migraine in others.

Complex Role of Hormones in Women’s Neurological Health

Estrogen and Neurological Health

Estrogen, often called the "hormone of femininity", does more than regulate reproductive functions. It is a powerful influencer of brain health. Estrogen modulates the activity of neurotransmitters like serotonin, which regulates mood and pain perception, and dopamine, associated with reward and pleasure.

During stages of hormonal stability, like in pregnancy's latter months, women may have fewer migraines because of the steady elevation of estrogen. However, a sudden downfall in estrogen destabilizes these chemicals in the brain, sending a heightened sensitivity for migraine triggers.

Menstrual Migraines

The most common form of hormonal migraines is menstrual migraines, which occur in response to the steep decline in estrogen levels just before menstruation. These are typically more intense and less responsive to standard treatment. The timing of these migraines provides clear evidence of the role hormones play in neurological health.

Pregnancy and Hormonal Shifts

Pregnancy is a rollercoaster of hormones. Although many women experience relief from migraines as a result of the constantly elevated levels of estrogen, some women, particularly in the first trimester, worsen. This individual variability is a characteristic of hormonal migraine triggers.

Hormonal Therapies and Management of Migraine

Hormonal treatments, such as oral contraceptives and HRT, have had mixed reviews regarding their use in managing migraine. Some women fare better with the stabilization the treatment provides, whereas others suffer worsening symptoms. This will depend on the nature and dose of the hormones used.

Post-Menopause: Migraine Remission or Continued Struggles?

For most women, menopause brings relief from their migraines. The decline in frequency and severity often accompanies stability in hormone levels. Even so, the susceptibility remains with some towards other forms of triggers including stress and sleep deprivation, not to forget diet-related factors and continues the saga of migraines well after the menopausal stages.

Effect on Neurological Health Due to Hormonal Changes

The relationship of hormones to neurological health goes beyond migraines. Hormonal changes have profound effects on a woman's brain in general.

Mood Disorders: Estrogen helps stabilize mood by regulating serotonin. Its decline at menopause increases the risk of mood swings and depression.

Neurodegenerative Diseases: Estrogen is neuroprotective, stimulating the growth and repair of brain cells. Its absence in post-menopausal women has been associated with an increased risk of Alzheimer's disease and cognitive decline.

Multiple Sclerosis (MS): Hormonal cycles may affect the course of MS, a disease that occurs more frequently in women than in men. Estrogen's anti-inflammatory effects provide transient protection during pregnancy, reducing relapse rates in women with MS.

"The intricate interplay between hormones and neurological health underscores the need for gender-specific treatment approaches," says Dr. Pai.

Managing Hormonal Migraines: Practical Strategies

While hormonal changes are inevitable, several strategies can help manage migraines effectively:

1. Tracking Your Cycle

Understanding your menstrual cycle can help identify patterns and predict when migraines might occur. This knowledge allows for preventive measures, such as scheduling medications or adjusting lifestyle habits.

2. Consulting Specialists

Working with a neurologist or gynecologist can help develop a personalized treatment plan. Options might include hormonal therapies, triptans, or preventive medications tailored to your specific needs.

3. Adopting a Healthy Lifestyle

A well-balanced diet, regular exercise, and stress management are all integral parts of managing migraines. For instance, magnesium-rich foods and hydration can help reduce the frequency and severity of attacks.

4. Exploring Preventive Therapies

For people with severe or frequent migraines, preventive medications, such as beta-blockers or CGRP inhibitors, may be prescribed. These medications stabilize brain activity and therefore reduce the chances of migraine during hormonal fluctuations.

5. Mind-Body Techniques

Techniques like yoga, meditation, and biofeedback can enhance wellness and reduce the debilitating effects of stress-one of the most common migraine triggers.

Research that was once in its embryonic stage continues to shed more light on the role of hormones in migraines and other neurological conditions. Further breakthroughs in genetic testing might enable doctors to predict, at least in a way, how an individual would react to hormonal therapies. The importance of gender-specific approaches is gradually being realized, which involves differentiating between the plight of women with migraines from others.

As Dr. Pai puts it, "Empowering women with knowledge about the hormonal underpinnings of migraines can lead to better, more personalized care. With the right strategies, migraines can be effectively managed, allowing women to lead fuller, healthier lives.

Migraines are not headaches; they are a complex neurological condition that deeply impacts the lives of millions of women. Understanding the role of hormones in triggering and exacerbating migraines is a vital step toward better management and relief.

Awareness, proactive care, and advances in medical research can help women regain their lives from the grip of hormonal migraines. Whether tracking cycles, adopting healthier habits, or seeking tailored medical care, every step taken toward understanding and managing migraines is a step toward empowerment.

Dr Shivananda Pai is a Consultant Neurology at KMC Hospital Dr B R Ambedkar Circle in Mangalore, India.

Brandes JL. The Influence of Estrogen on Migraine: A Systematic Review. JAMA. 2006;295(15):1824–1830. doi:10.1001/jama.295.15.1824

Sacco S, Ricci S, Degan D, Carolei A. Migraine in women: the role of hormones and their impact on vascular diseases. J Headache Pain. 2012 Apr;13(3):177-89. doi: 10.1007/s10194-012-0424-y. Epub 2012 Feb 26. PMID: 22367631; PMCID: PMC3311830.

Perimenopause has become a regular conversation and its been high time that people are talking about it. You can see friends discussing it, social media coverage has increased and more importantly women are discussing this with their gynaecologists.

For decades, menopause was thought to be a single event - that is the day the periods stopped, but today we understand that the transition lasts for a few years. These changes can affect the quality of a woman’s life and hence I’m glad the conversation has gained more traction.

Perimenopause-Related Changes

Also read: Yoga Or Strength Training: What Can Help Manage Hot Flashes During Perimenopause?

First lets understand what perimenopause is. It literally means “around menopause” Its a transition phase where the ovaries gradually change the production of the hormones, mainly oestrogen and progesterone. It usually begins in the early 40’s but some women may experience it earlier.

One of the commonest signs of this is a change in the pattern of your menstrual cycle. Periods can be become longer or shorter, heavier or lighter. Basically the menstrual cycle becomes a bit unpredictable.

But periods aren’t the only sign. A woman may start experiencing disturbed sleep cycles. She may wake up randomly at 3am or feel exhausted despite getting 7-8 hours of sleep. Hot flushes and night sweats may also occur. Mood changes, irritability, anxiety and difficulty in concentration can also affect her quality of life.

Some women complain of being forgetful or more commonly used term "experience brain fog”. They forget names, lose train of though or struggle to multitask. There can also be a change in libido, vaginal dryness, discomfort during intercourse, headaches, join pain and alterations in skin and hair.

Besides this there could possibly a change in the body composition. A woman may notice increasing abdominal fat or find difficulty in maintaining her weight even though her lifestyle hasn’t changed.

Why The Current Focus On Wellness Is Important?

Also read: Explained: Why Some Women Start Experiencing Joint Pain As They Approach Menopause

The good part of this increase in awareness is that women are paying more attention to their health early rather than waiting of menopause. This transition phase provides a golden opportunity to reassess exercise, nutrition, sleep and preventative healthcare.

Strength training becomes even more valuable as it helps maintain muscle and bone mass.

Adequate protein, calcium and Vitamin D intake along with a balanced diet helps long term metabolic and bone health.

During this time, its important for a woman to even assess her cardiovascular health. Blood pressure, cholesterol, blood sugar and weight don’t just become numbers on the chart anymore, they become important markers of future health during this time.

Not Every Symptom Should Be Blamed On Hormones

However every label shouldn’t be blamed on perimenopause. Thyroid disorders, anaemia, vitamin deficiencies, depression and few other medical conditions can produce similar symptoms.

Unusually heavy bleeding, bleeding between periods or after intercourse also warrants medical assessment rather than being dismissed as “just hormones”.

With the increasing accessibility of GLP-1 weight-loss drugs such as Ozempic and Wegovy, more people are shedding pounds. But the transformation can come with its own caveats — sagging skin, hair loss and dental issues that may require further attention.

And if you thought women were the only ones taking the plunge, think again.

While women still account for the overwhelming majority of aesthetic treatments, demand among men in the US has risen in recent years, particularly among those who have undergone significant weight loss through GLP-1 therapies.

More US Men Seek Cosmetic Treatments

According to the American Society of Plastic Surgeons, men underwent 1.7 million cosmetic procedures in 2024, including surgeries and minimally invasive treatments such as laser skin resurfacing and Botox injections. That was a 2.7% increase from the previous year.

Of the total, more than 98,000 were surgeries, with eyelid surgery, liposuction and tummy tucks among the most commonly performed procedures.

“I’ve seen probably a doubling in the number of male patients that I treat over the last one to two years,” Sean Alemi, a New York-based facial plastic surgeon, was quoted as saying to Reuters.

Also read: Lehengas, Diets & Now Mounjaro: The New Must-Have For Indian Brides?

Experts say demand will keep rising as more weight-loss drugs, including new pill versions, reach the market.

In the first quarter of 2026, nearly 70% of men who underwent surgical procedures had a history of GLP-1 use, Dr. Bob Basu, president of the American Society of Plastic Surgeons, said.

Younger men often seek procedures to remove loose skin and improve the appearance of an athletic physique, while older men are focused on signs of aging, particularly in the face and neck, doctors said.

Rapid Weight Loss May Affect Surgical Outcomes

Read More: GLP-1 Drugs Making You Lose Muscle Along With Fat? Scientists Discover Game Changing Weight-Loss Compound To Tackle It

The growing popularity of GLP-1 drugs has also created a new generation of body-contouring patients, along with new challenges for plastic surgeons, according to recent research by Duke University.

The research suggests that how much weight patients lose — and how quickly they lose it — could affect surgical results when tightening or removing excess skin after massive weight loss.

For the study, published in Plastic and Reconstructive Surgery, Duke researchers analyzed more than a decade of abdominal body-contouring procedures, such as tummy tucks, and found that patients who lost large amounts of weight quickly faced higher risks of surgical complications.

The more than 500 patients studied were grouped based on how they lost weight: through bariatric surgery alone, GLP-1 medications such as semaglutide and tirzepatide alone, or a combination of both.

The highest complication rates were seen among patients who combined surgery with GLP-1 drugs that reduce appetite. These patients not only lost the most weight overall — about 29% of their body weight, compared with 10% among GLP-1 users — but did so at the fastest rate.

A New Challenge for Plastic Surgeons

But those rapid changes may come with tradeoffs, said senior study author and professor of surgery Ash Patel, MBChB, a plastic and reconstructive surgeon at Duke Health.

“These are highly effective weight-loss tools, and they are changing the patient population we see in body contouring,” Patel said. “We’re operating on people whose bodies have undergone rapid, profound changes, and that affects healing.”

Kidneys are two bean shaped structures, located on the back side of the abdomen, one each on right and left side. It filters blood by removing waste products via urine. Besides this it also functions as an endocrine organ, producing hormones like renin (for blood pressure control), erythropoietin (for hemoglobin production) and aids in active vitamin D formation (for bone health).

Though human beings have two kidneys usually, there are situations where individuals can lead a healthy life on one kidney. This could be developmental anomaly (since birth). Congenital absence of one kidney is called renal agenesis, and these individuals lead a normal life with normal kidney function.

Sometimes, a single kidney is acquired due to removal of one kidney for donation. As in a healthy donor gives their kidney to someone in need, whose both kidneys have failed. This is indeed a noble gesture and one that does not come with any significant impact on the donor’s quality of life.

Can You Live With One Kidney After Donation?

Also read: When a Fever Is More Than a Fever: Recurrent UTIs in Children Can Put Kidneys at Risk

The process of organ donation, where a healthy person’s healthy kidney is removed for the therapeutic purpose to benefit another individual suffering from kidney failure, is called donor nephrectomy. The first such surgery was done in the USA in the year 1954, with open surgery.

Now a days, most donor nephrectomies are done either with laparoscopy (key hole surgery) or robot assisted. Thus, a question that often arises in such times is, whether one can live with one kidney after kidney organ donation? To understand this, one should first understand that a donor undergoes a thorough rigorous fitness evaluation to determine if kidney donation is viable.

During this evaluation process, kidney function of both kidneys are evaluated. The kidney donor is deemed fit to donate the kidney only after it is ascertained that the donor has two healthy kidneys free from any disease, and the donor would be able to lead a normal life with one kidney. it is also ascertained that the other kidney transplanted in another is also having good kidney function to survive in the recipient.

What Happens To The Donor After Kidney Donation?

Another commonly asked question that doctors often get is, what happens to the kidney donor with one kidney after donation? Most kidney donors live long healthy life after organ donation. However, it should be appreciated that every individual is different, and age at the time of organ donation matters a lot. Risk is generally low, and they carry out their regular activities as before. Rarely the donor has a slight chance of developing high blood pressure or protein leak in the urine.

However, overall risk of significant kidney disease is <1%, which is considered less than having the similar risk in general population. Though, there may be slightly higher chances of developing high blood pressure during pregnancy in a kidney donor. However, in majority of cases, Kidney donation is generally a safe procedure, and most donors continue to lead healthy, active lives with one kidney. With appropriate long-term follow-up and healthy lifestyle choices, donors can maintain excellent kidney health after donation.

By Dr. Hemant Mehta, Consultant Interventional Nephrologist, Lilavati Hospital and Research Center, Mumbai