For those who have not experienced a migraine, perhaps it would seem just another headache. But for someone like me who has suffered through migraines that will last over a week even with medication, I can definitely tell you that it's much more. The ache is not confined to the head; it's the whole experience. Nausea, sensitivity to light, and throbs so bad it makes simple tasks unbearable. It also comes with an emotional burden—the loneliness and frustration are pretty unbearable. Through the years, realizing how hormones are also implicated in triggering and exacerbating my migraines has helped change the game in my dealing with these episodes.

What are Hormonal Migraines?

Hormonal migraines are caused by fluctuations in estrogen and progesterone, the two main female hormones. These hormones are essential for the reproductive system, regulating menstrual cycles and pregnancy. They also have an effect on brain chemicals, such as serotonin and dopamine, which affect mood and pain perception. When hormone levels fluctuate, such as during menstruation, pregnancy, or menopause, they can destabilize the pathways in the brain, causing migraines.

According to Dr. Shivananda Pai, Consultant Neurology, migraines are more than a neurological disorder. "Migraines represent a complex interplay of genetic, environmental, and hormonal factors. In women, hormonal fluctuations are a critical trigger that amplifies sensitivity to pain," he explains. Hormonal headaches are particularly challenging because they are influenced by multiple life stages, from puberty to post-menopause. Common causes include:

• Menstrual periods: Estrogen levels significantly drop just before menstruation often triggers a migraine.
• Pregnancy: Hormones can act to relieve symptoms or aggravate them during different times of pregnancy.
• Menopause: The hormonal fluctuation during menopause can intensify a migraine, while some women tend to find relief.
• Hormonal therapies: Birth control and HRT tend to level off hormone balances in some individuals but will exacerbate a migraine in others.

Complex Role of Hormones in Women’s Neurological Health

Estrogen and Neurological Health

Estrogen, often called the "hormone of femininity", does more than regulate reproductive functions. It is a powerful influencer of brain health. Estrogen modulates the activity of neurotransmitters like serotonin, which regulates mood and pain perception, and dopamine, associated with reward and pleasure.

During stages of hormonal stability, like in pregnancy's latter months, women may have fewer migraines because of the steady elevation of estrogen. However, a sudden downfall in estrogen destabilizes these chemicals in the brain, sending a heightened sensitivity for migraine triggers.

Menstrual Migraines

The most common form of hormonal migraines is menstrual migraines, which occur in response to the steep decline in estrogen levels just before menstruation. These are typically more intense and less responsive to standard treatment. The timing of these migraines provides clear evidence of the role hormones play in neurological health.

Pregnancy and Hormonal Shifts

Pregnancy is a rollercoaster of hormones. Although many women experience relief from migraines as a result of the constantly elevated levels of estrogen, some women, particularly in the first trimester, worsen. This individual variability is a characteristic of hormonal migraine triggers.

Hormonal Therapies and Management of Migraine

Hormonal treatments, such as oral contraceptives and HRT, have had mixed reviews regarding their use in managing migraine. Some women fare better with the stabilization the treatment provides, whereas others suffer worsening symptoms. This will depend on the nature and dose of the hormones used.

Post-Menopause: Migraine Remission or Continued Struggles?

For most women, menopause brings relief from their migraines. The decline in frequency and severity often accompanies stability in hormone levels. Even so, the susceptibility remains with some towards other forms of triggers including stress and sleep deprivation, not to forget diet-related factors and continues the saga of migraines well after the menopausal stages.

Effect on Neurological Health Due to Hormonal Changes

The relationship of hormones to neurological health goes beyond migraines. Hormonal changes have profound effects on a woman's brain in general.

Mood Disorders: Estrogen helps stabilize mood by regulating serotonin. Its decline at menopause increases the risk of mood swings and depression.

Neurodegenerative Diseases: Estrogen is neuroprotective, stimulating the growth and repair of brain cells. Its absence in post-menopausal women has been associated with an increased risk of Alzheimer's disease and cognitive decline.

Multiple Sclerosis (MS): Hormonal cycles may affect the course of MS, a disease that occurs more frequently in women than in men. Estrogen's anti-inflammatory effects provide transient protection during pregnancy, reducing relapse rates in women with MS.

"The intricate interplay between hormones and neurological health underscores the need for gender-specific treatment approaches," says Dr. Pai.

Managing Hormonal Migraines: Practical Strategies

While hormonal changes are inevitable, several strategies can help manage migraines effectively:

1. Tracking Your Cycle

Understanding your menstrual cycle can help identify patterns and predict when migraines might occur. This knowledge allows for preventive measures, such as scheduling medications or adjusting lifestyle habits.

2. Consulting Specialists

Working with a neurologist or gynecologist can help develop a personalized treatment plan. Options might include hormonal therapies, triptans, or preventive medications tailored to your specific needs.

3. Adopting a Healthy Lifestyle

A well-balanced diet, regular exercise, and stress management are all integral parts of managing migraines. For instance, magnesium-rich foods and hydration can help reduce the frequency and severity of attacks.

4. Exploring Preventive Therapies

For people with severe or frequent migraines, preventive medications, such as beta-blockers or CGRP inhibitors, may be prescribed. These medications stabilize brain activity and therefore reduce the chances of migraine during hormonal fluctuations.

5. Mind-Body Techniques

Techniques like yoga, meditation, and biofeedback can enhance wellness and reduce the debilitating effects of stress-one of the most common migraine triggers.

Research that was once in its embryonic stage continues to shed more light on the role of hormones in migraines and other neurological conditions. Further breakthroughs in genetic testing might enable doctors to predict, at least in a way, how an individual would react to hormonal therapies. The importance of gender-specific approaches is gradually being realized, which involves differentiating between the plight of women with migraines from others.

As Dr. Pai puts it, "Empowering women with knowledge about the hormonal underpinnings of migraines can lead to better, more personalized care. With the right strategies, migraines can be effectively managed, allowing women to lead fuller, healthier lives.

Migraines are not headaches; they are a complex neurological condition that deeply impacts the lives of millions of women. Understanding the role of hormones in triggering and exacerbating migraines is a vital step toward better management and relief.

Awareness, proactive care, and advances in medical research can help women regain their lives from the grip of hormonal migraines. Whether tracking cycles, adopting healthier habits, or seeking tailored medical care, every step taken toward understanding and managing migraines is a step toward empowerment.

Dr Shivananda Pai is a Consultant Neurology at KMC Hospital Dr B R Ambedkar Circle in Mangalore, India.

Brandes JL. The Influence of Estrogen on Migraine: A Systematic Review. JAMA. 2006;295(15):1824–1830. doi:10.1001/jama.295.15.1824

Sacco S, Ricci S, Degan D, Carolei A. Migraine in women: the role of hormones and their impact on vascular diseases. J Headache Pain. 2012 Apr;13(3):177-89. doi: 10.1007/s10194-012-0424-y. Epub 2012 Feb 26. PMID: 22367631; PMCID: PMC3311830.

Every year on December 1, World AIDS Day reminds us that HIV continues to be a global concern, and in 2025 the focus is on "Overcoming disruption, transforming the AIDS response. Early testing and treatment are key to making that transformation real. The sooner HIV is detected and treated, the better the long-term health outcomes. India has made notable progress.

According to 2023 estimates, adult HIV prevalence is around 0.2%, and prevention and treatment programmes using medication continue to expand. Still, challenges remain: gaps in testing, delayed diagnoses, and interruptions in care persist—issues World AIDS Day 2025 urges us to address.

World AIDS Day 2025: Why HIV Diagnosis Is Important

HIV is still a very real health concern today. It can affect anyone, students, professionals, or those in stable relationships—especially if needles or syringes are shared or protection is not used.

Once HIV enters the body, it gradually weakens the immune system. If left undetected and untreated, it can progress to AIDS, leaving even minor infections dangerous. The good news is that this progression can be prevented. With early testing and proper treatment, people living with HIV can lead full, healthy, and normal lives.

Dr. R K Gattani, Senior Consultant Physician at Kailash Hospital & Heart Institute, Noida, says, "Early testing is an important form of self-care. Choosing to get tested shows you are taking responsibility for your health—it doesn’t mean something is wrong."

Meanwhile, Dr. Vaibhav Gupta, Senior Consultant in Internal Medicine, Critical Care, and Diabetology at Regency Health Kanpur, adds, "Detecting HIV early allows doctors to begin Antiretroviral Therapy (ART) straight away, keeping the immune system strong, preventing AIDS, and reducing transmission risk almost to zero. In a world where millions are diagnosed each year, early recognition is one of the strongest tools young Indians have to protect themselves and their partners."

What Is Modern Antiretroviral Therapy?

Today’s ART enables people diagnosed early to live long, healthy, and productive lives. It keeps the virus under control, safeguards the immune system, and dramatically lowers the chance of passing HIV to others. Early diagnosis also gives young people the knowledge to make safer lifestyle choices.

Dr. Aabid Amin Bhat, Medical Director at Ujala Cygnus Group of Hospitals, explains, "Encouraging open discussions, expanding access to youth-friendly testing, and fighting stigma are essential steps. When HIV is found early, it’s not the end; it’s the start of informed care, timely treatment, and a healthier future."

The challenge is that early HIV symptoms often look like common illnesses like fever, fatigue, sore throat, swollen lymph nodes, and rashes—which can be easily ignored. Without prompt testing, the virus may advance silently, making treatment more complex. Early testing also opens doors to preventive options like post-exposure prophylaxis (PEP), which can prevent infection if taken within 72 hours of potential exposure. Recognizing early signs and seeking confidential, judgment-free testing allows young Indians to stop HIV before it develops into AIDS, turning a potentially life-altering diagnosis into a manageable condition.

HIV prevention is simpler than many think. Basic precautions like using protection during intimate contact, avoiding sharing needles or items that could contact blood, and staying informed about your health—make a huge difference. Anyone who may have been exposed should immediately consult a healthcare professional for guidance. Above all, don’t hesitate to get tested, ask questions, or seek help. Taking care of your health is the most responsible and empowering way to protect your future. People living with HIV, when on proper treatment and taking necessary precautions, should not automatically be seen as a risk to others.

Education and awareness remain key. Safe practices, timely diagnosis, and access to treatment can transform HIV from a feared disease into a manageable condition, giving young Indians control over their health and future.

World AIDS Day is marked across the globe every year on 1 December to draw attention to HIV and AIDS. In India, the day is observed through awareness drives and community-level programmes held nationwide. The National AIDS Control Organization (NACO), which functions under the Ministry of Health and Family Welfare, leads these efforts and brings people together to support the ongoing battle against the illness.

This year, the government reported a strong decline in HIV cases, noting 49 per cent fewer new infections since 2010, an 81 per cent fall in deaths linked to AIDS, and a 75 per cent drop in mother-to-child transmission between 2010 and 2024.

The update, shared on Sunday for World AIDS Day 2025, also underlines how myths continue to harm people living with HIV. Misconceptions remain widespread, including the belief that the virus spreads through simple physical contact.

What is HIV/AIDS?

The Human Immunodeficiency Virus (HIV) harms the body by attacking helper T-cells, which are vital for immunity. Acquired Immunodeficiency Syndrome (AIDS) develops when these cells fall to very low levels, leaving the body exposed to infections and diseases, as described by the Mayo Clinic.

Common HIV Myths That You Should Know About

• It is a myth that HIV spreads through coughing, touching or shaking hands. Routine contact or a cough does not transmit the virus. Transmission can occur only when the skin has open sores or breaks that allow the virus to enter.
• It is a myth that a person diagnosed with HIV will survive only a short time. With proper treatment that keeps the virus suppressed, people with HIV can live for many years.
• It is a myth that every child born to an HIV-positive mother will also have HIV. With antiretroviral therapy, a planned C-section and other precautions, the chance of passing the virus to the baby can be reduced to below 2 per cent.
• It is a myth that HIV, being a viral infection, cannot be linked to the use of antibacterial or antifungal medicines. Since HIV weakens immunity, those living with it may be prone to common bacterial and fungal infections and may need such medicines for long periods.
• It is a myth that there is no risk when two or more HIV-positive partners are intimate. Unprotected sex can still allow tougher or drug-resistant strains of the virus to evolve and spread.
• It is a myth that people who do not show symptoms cannot have HIV. It can take years for signs to appear, and the only way to confirm the infection is through testing.
• It is a myth that taking medicines before intercourse can fully prevent HIV. Pre-exposure prophylaxis lowers the risk but does not remove it entirely.

World AIDS Day, observed each year on December 1, is a time to pause, acknowledge and renew our commitment. It pays respect to those who lost their lives to AIDS-related illnesses, offers support to people living with HIV and reminds the world that prevention, treatment and rights-based care remain essential. The theme for 2025, “Overcoming disruption, transforming the AIDS response”, urges countries to build stronger systems, widen access to services and uphold the dignity of all communities affected by HIV.

Ludwig Minelli, 92, died on Saturday just days before his 93rd birthday, which would have been on December 5. He was the founder of Swiss right-to-die organization Dignitas. He has died by assisted suicide.

The members of organization paid tribute to him and said that he had always led a "life for freedom of choice, self-determination, and human rights".

Right-To-Die By Minelli

Minelli founded Dignitas in 1998, which has helped many people to choose how they wish to die with dignity. He however began his career as a journalist and worked as a correspondent for the German news magazine Der Spiegel. He then studied law and that is when his interest in human rights took off.

Throughout his life, he campaigned for the right to die and gave Dignitas the slogan: "dignity in life, dignity in death".

"I am persuaded that we have to struggle in order to implement the last human right in our societies. And the last human right is the right to make a decision on one's own end, and the possibility to have this end without risk and without pain," he said in a 2010 BBC interview.

He founded Dignitas after he split from an older Swiss assisted dying organization, Exit, because he said the rules felt too restrictive.

The reason for Dignitas to become famous was because the way it operated. Dignitas offered assisted suicide to non-Swiss citizens who travel to Switzerland because assisted dying is not permitted in their own countries. In a 2008 interview to Der Tagesspiegel, he said that Dignitas assisted 840 people to die, and 60% of them were Germans.

Also Read: Supreme Court Steps In For 31-year-old's Passive Euthanasia Plea Who Has Been In Vegetative State For 10 Years

His Life Amid Criticism And Legal Battles

While he devoted his life for a cause, he was not spared from criticism. He was often criticized for an alleged lack of transparency over the financial dealings of the organization. He was further criticized for offering assisted dying options to those who were not terminally ill, but wanted to end their lives. He also faced numerous legal battles, and many of which were also appealed to Swiss apex court.

The Wins He Made

As per Dignitas, his work had a lasting influence. In 2011, the European Court of Human Rights announced the right of a person capable of judgment to decide on the manner and the time of their own end of life.

While in his own country, assisted dying was permitted under Swiss law since 1942, under strict condition, of course, Euthanasia still remains illegal there.

The main difference is that in Switzerland, a physician cannot administer a lethal injection, which is what euthanasia is. However, a physician can provide the means for a person to end their own life, and the individual must perform the final act themselves.

The legality of assisted suicide is based on Article 115 of the Swiss Criminal Code from 1942, which prohibits assistance only if motivated by selfish reason. The conditions for assisted suicide includes that the assistance must not be for selfish motives and must be provided to someone of sound mind who has made a self-determined and enduring decision to die. The person must also be suffering from an unbearable and uncontrollable condition.