For those who have not experienced a migraine, perhaps it would seem just another headache. But for someone like me who has suffered through migraines that will last over a week even with medication, I can definitely tell you that it's much more. The ache is not confined to the head; it's the whole experience. Nausea, sensitivity to light, and throbs so bad it makes simple tasks unbearable. It also comes with an emotional burden—the loneliness and frustration are pretty unbearable. Through the years, realizing how hormones are also implicated in triggering and exacerbating my migraines has helped change the game in my dealing with these episodes.

What are Hormonal Migraines?

Hormonal migraines are caused by fluctuations in estrogen and progesterone, the two main female hormones. These hormones are essential for the reproductive system, regulating menstrual cycles and pregnancy. They also have an effect on brain chemicals, such as serotonin and dopamine, which affect mood and pain perception. When hormone levels fluctuate, such as during menstruation, pregnancy, or menopause, they can destabilize the pathways in the brain, causing migraines.

According to Dr. Shivananda Pai, Consultant Neurology, migraines are more than a neurological disorder. "Migraines represent a complex interplay of genetic, environmental, and hormonal factors. In women, hormonal fluctuations are a critical trigger that amplifies sensitivity to pain," he explains. Hormonal headaches are particularly challenging because they are influenced by multiple life stages, from puberty to post-menopause. Common causes include:

• Menstrual periods: Estrogen levels significantly drop just before menstruation often triggers a migraine.
• Pregnancy: Hormones can act to relieve symptoms or aggravate them during different times of pregnancy.
• Menopause: The hormonal fluctuation during menopause can intensify a migraine, while some women tend to find relief.
• Hormonal therapies: Birth control and HRT tend to level off hormone balances in some individuals but will exacerbate a migraine in others.

Complex Role of Hormones in Women’s Neurological Health

Estrogen and Neurological Health

Estrogen, often called the "hormone of femininity", does more than regulate reproductive functions. It is a powerful influencer of brain health. Estrogen modulates the activity of neurotransmitters like serotonin, which regulates mood and pain perception, and dopamine, associated with reward and pleasure.

During stages of hormonal stability, like in pregnancy's latter months, women may have fewer migraines because of the steady elevation of estrogen. However, a sudden downfall in estrogen destabilizes these chemicals in the brain, sending a heightened sensitivity for migraine triggers.

Menstrual Migraines

The most common form of hormonal migraines is menstrual migraines, which occur in response to the steep decline in estrogen levels just before menstruation. These are typically more intense and less responsive to standard treatment. The timing of these migraines provides clear evidence of the role hormones play in neurological health.

Pregnancy and Hormonal Shifts

Pregnancy is a rollercoaster of hormones. Although many women experience relief from migraines as a result of the constantly elevated levels of estrogen, some women, particularly in the first trimester, worsen. This individual variability is a characteristic of hormonal migraine triggers.

Hormonal Therapies and Management of Migraine

Hormonal treatments, such as oral contraceptives and HRT, have had mixed reviews regarding their use in managing migraine. Some women fare better with the stabilization the treatment provides, whereas others suffer worsening symptoms. This will depend on the nature and dose of the hormones used.

Post-Menopause: Migraine Remission or Continued Struggles?

For most women, menopause brings relief from their migraines. The decline in frequency and severity often accompanies stability in hormone levels. Even so, the susceptibility remains with some towards other forms of triggers including stress and sleep deprivation, not to forget diet-related factors and continues the saga of migraines well after the menopausal stages.

Effect on Neurological Health Due to Hormonal Changes

The relationship of hormones to neurological health goes beyond migraines. Hormonal changes have profound effects on a woman's brain in general.

Mood Disorders: Estrogen helps stabilize mood by regulating serotonin. Its decline at menopause increases the risk of mood swings and depression.

Neurodegenerative Diseases: Estrogen is neuroprotective, stimulating the growth and repair of brain cells. Its absence in post-menopausal women has been associated with an increased risk of Alzheimer's disease and cognitive decline.

Multiple Sclerosis (MS): Hormonal cycles may affect the course of MS, a disease that occurs more frequently in women than in men. Estrogen's anti-inflammatory effects provide transient protection during pregnancy, reducing relapse rates in women with MS.

"The intricate interplay between hormones and neurological health underscores the need for gender-specific treatment approaches," says Dr. Pai.

Managing Hormonal Migraines: Practical Strategies

While hormonal changes are inevitable, several strategies can help manage migraines effectively:

1. Tracking Your Cycle

Understanding your menstrual cycle can help identify patterns and predict when migraines might occur. This knowledge allows for preventive measures, such as scheduling medications or adjusting lifestyle habits.

2. Consulting Specialists

Working with a neurologist or gynecologist can help develop a personalized treatment plan. Options might include hormonal therapies, triptans, or preventive medications tailored to your specific needs.

3. Adopting a Healthy Lifestyle

A well-balanced diet, regular exercise, and stress management are all integral parts of managing migraines. For instance, magnesium-rich foods and hydration can help reduce the frequency and severity of attacks.

4. Exploring Preventive Therapies

For people with severe or frequent migraines, preventive medications, such as beta-blockers or CGRP inhibitors, may be prescribed. These medications stabilize brain activity and therefore reduce the chances of migraine during hormonal fluctuations.

5. Mind-Body Techniques

Techniques like yoga, meditation, and biofeedback can enhance wellness and reduce the debilitating effects of stress-one of the most common migraine triggers.

Research that was once in its embryonic stage continues to shed more light on the role of hormones in migraines and other neurological conditions. Further breakthroughs in genetic testing might enable doctors to predict, at least in a way, how an individual would react to hormonal therapies. The importance of gender-specific approaches is gradually being realized, which involves differentiating between the plight of women with migraines from others.

As Dr. Pai puts it, "Empowering women with knowledge about the hormonal underpinnings of migraines can lead to better, more personalized care. With the right strategies, migraines can be effectively managed, allowing women to lead fuller, healthier lives.

Migraines are not headaches; they are a complex neurological condition that deeply impacts the lives of millions of women. Understanding the role of hormones in triggering and exacerbating migraines is a vital step toward better management and relief.

Awareness, proactive care, and advances in medical research can help women regain their lives from the grip of hormonal migraines. Whether tracking cycles, adopting healthier habits, or seeking tailored medical care, every step taken toward understanding and managing migraines is a step toward empowerment.

Dr Shivananda Pai is a Consultant Neurology at KMC Hospital Dr B R Ambedkar Circle in Mangalore, India.

Brandes JL. The Influence of Estrogen on Migraine: A Systematic Review. JAMA. 2006;295(15):1824–1830. doi:10.1001/jama.295.15.1824

Sacco S, Ricci S, Degan D, Carolei A. Migraine in women: the role of hormones and their impact on vascular diseases. J Headache Pain. 2012 Apr;13(3):177-89. doi: 10.1007/s10194-012-0424-y. Epub 2012 Feb 26. PMID: 22367631; PMCID: PMC3311830.

As 2025 comes to an end, one thing is clear, this year has been a year of remarkable shifts in how we understand health. This year, there have been breakthroughs, redesigns, and achievements in the healthcare sector, which has changed many lives. Scientists and doctors have pushed their boundaries in ways to save lives, make patients more comfortable and Health and Me lists down 5 such breakthroughs that defined the year 2025.

Reinventing Speculum: The Flower That May Transform Pelvic Exams

Few medical tools have stayed as frozen in time as the vaginal speculum. Cold, metallic, and intimidating, its origin traces back to Dr. James Marion Sims in the mid-19th century, during experiments carried out unethically on enslaved women. Beyond its history, patients have long reported pain, anxiety, and emotional distress linked to it. But this year, a young design team dared to ask what would happen if pelvic exams could feel safe.

Enter Lilium, a flower-inspired speculum created by Delft University engineers Tamara Hoveling and Ariadna Izcara Gual. Made with soft plastic and shaped to bloom like a lily, it opens gently, eliminates the harsh clicking sound, and uses a tampon-like applicator for insertion. Designed to feel familiar and symbolically comforting, Lilium represents a shift toward trauma-informed, patient-first gynecological care—something long overdue.

Zaynich: India Launches Its First New Antibiotic in 30+ Years

For 28-year-old Sahil Mehra from Mumbai, a severe, drug-resistant Pseudomonas infection left his kidneys failing and his doctors nearly out of options. Even last-resort antibiotics couldn’t stop the superbug.

Then came Zaynich, India’s first new antibiotic in more than three decades. Developed by Wockhardt, it combines cefepime, a fourth-generation cephalosporin, with zidebactam, a novel β-lactam enhancer that boosts the drug’s power against tough bacteria. Early reports and trials suggest a 97% effectiveness against drug-resistant Gram-negative bacteria and even a 20% higher cure rate than meropenem in Phase 3 studies. Within four days of receiving Zaynich, Mehra’s condition stabilized—a reminder of why antibiotic innovation is essential in the age of superbugs.

A Powerful Cholesterol-Lowering Pill Could Change Heart Care

High LDL cholesterol remains one of the biggest drivers of cardiovascular disease. While statins help, many people never reach target levels. Injectable PCSK9 inhibitors work well but remain expensive and less accessible.

This year, an experimental daily pill—enlicitide—showed promise of changing that equation. In the Phase 3 CORALreef Lipids trial involving 2,912 adults, enlicitide reduced LDL-C levels by 55.8% at 24 weeks, with post-hoc analysis suggesting reductions up to 59.7%. With a safety profile similar to placebo, enlicitide could become the first oral PCSK9 inhibitor to make potent cholesterol control easier and more widely available.

Zombie Cell: A Longevity Pill From China Claims Life Up to 150 Years

A Shenzhen-based biotech company sparked global debate by claiming it has developed a pill that targets ageing at the cellular level. The pill focuses on clearing “zombie cells”—old cells that refuse to die and trigger inflammation. Made with compounds derived from grape seeds, early animal lab work suggests potential lifespan extension. While far from proven in humans, the idea that such a pill could stretch life to 120–150 years captured the world’s imagination and intensified conversations around longevity science.

The World’s First Single-Dose Dengue Vaccine Gets Approved

With dengue cases hitting record levels globally, Brazil approved the world’s first single-dose dengue vaccine, called Butantan-DV. Developed by the Butantan Institute in collaboration with Wu Xi, it uses a live attenuated virus and is currently approved for ages 12 to 59. Until now, the only dengue vaccine required two doses months apart. This single-shot version could transform dengue prevention, especially in tropical countries facing surges linked to rising temperatures.

Recently the news of Norovirus outbreak in an AIDA cruise that has infected more than 100 guests and crew on board made news. This is the 21st outbreak, as confirmed by the Centers for Disease Control and Prevention (CDC). This case has brought back memories from the Royal Caribbean Cruise outbreak, where 94 out of 1,874 and 4 crew members also were infected by Norovirus.

This virus is also known as the 'rib-cracking' winter virus, which sets it apart from rest of the winter viruses. People who have been sickened by this contagious virus are vomiting explosively, which may make the sufferers to experience a cracking in their ribs, which is where it gets its name 'rib-cracking' winter virus.

What Is Norovirus? What Makes It So Unique?

The virus typically spikes after the holidays, when families gather indoors. However, new data from the Centers for CDC shows this year’s surge has arrived weeks ahead of schedule, and experts say there’s no obvious explanation yet.

According to the CDC, 12.5 percent of norovirus tests came back positive during the week of November 22, nearly identical to the 13 percent positivity rate the week before. Compared to two weeks earlier, infections have jumped by about 25 percent. But the real number of cases is likely far higher, as most people with norovirus never get tested.

Between August 1 and November 13, health officials recorded 153 norovirus outbreaks, more than double last year’s 69 during the same period, and far above the 65 reported in 2023.

The CDC estimates the U.S. sees around 2,500 outbreaks every year. An outbreak is recorded when two or more people fall ill from a suspected or confirmed shared source.

On cruise ships, which are closely monitored by federal agencies, outbreaks have also been climbing. The AIDAdiva, a German vessel currently on a long global route, recently reported a spike in cases. In a statement to USA TODAY, AIDA Cruises said it has increased hygiene measures on board and that infections are already declining.

“Seasonal illness peaks between November and April, and the AIDAdiva report reflects what we’re seeing on land,” the cruise line said.

Why Norovirus Hits So Hard

Norovirus infects roughly 21 million Americans every year and sends about 2 million to hospitals or clinics. It spreads easily through contaminated food, surfaces, shared utensils, or direct contact with an infected person. Even a tiny amount of virus can trigger illness.

Symptoms usually appear within 12 to 48 hours and include nausea, vomiting, diarrhea, stomach cramps, and sometimes fever and chills. The biggest danger is dehydration, which can set in quickly. Severe fluid loss can lead to low blood pressure, reduced organ perfusion, electrolyte imbalances, and in extreme cases, seizures or fainting.

The virus contributes to about 900 deaths in the U.S. annually, mostly among older adults.

Doctors emphasize that hand sanitizers don’t reliably kill norovirus. Frequent handwashing with soap and water is the best protection.

The season’s lowest positivity rate was recorded in early August at 6.5 percent. But with holiday travel and gatherings underway, health officials warn infections are likely to rise.

What Are The Symptoms Of Norovirus And How Long Do They Last?

• Nausea
• Vomiting
• Stomach pain or cramps
• Watery or loose diarrhea
• Feeling ill
• Low-grade fever
• Muscle pain

The symptoms usually begin 12 to 48 hours after your first exposure to the virus and could last from 1 to 3 days. You can, however, continue to shed virus in your stool for several week after your recovery. The shedding could go up for months if you have another medical condition.

Delhi woke up again to a thick layer of smog, with Delhi's AQI hovering over 300 on the Air Quality Index on Thursday morning under "very poor" category. After a long nine-day wait, city's AQI had slipped under "poor" category on Tuesday, but it is again back on the "very poor" category, while on Wednesday, there were strong winds that dispersed the pollutants. Yet the condition of the air quality remains bad.

As a result of this many people are leaving the city, or have at least considered leaving the city.

"I Felt Breathless And Constantly Fatigued"

Nikita Singh, 31, who runs a remote PR boutique agency was living in Delhi on and off for two years because it was two years back when she struggled to breathe during Delhi winters. "The pollution levels were so extreme that I felt breathless and constantly fatigued. That was the first time I seriously questioned whether I could continue living here long-term," she says.

For the first two years, she kept "oscillating". "I would stay in Delhi for work during peak months, then leave when pollution became unbearable, especially from November to January. Every return felt heavier. I had my eyes burning, headaches, chest tightness and a general feeling of 'I cannot do this forever'."

She has now permanent moved away from Delhi to Jodhpur, in Rajasthan, where she works remotely. However, it has not been easy on her. "Emotionally, it was tough because Delhi had become familiar, and my life and work circle were mostly based there," she says. However, thanks to her fully remote work and that fact that she had decided to prioritize her health, she was able to make the move.

She says that Jodhpur offers the cleaner air which she "never felt in Delhi". Her decision to move also came with her family uprooting from Delhi. "My family and I shifted together. AQI was a major trigger. We realized we could not keep exposing ourselves to those levels of pollution year after year," she reveals.

Migration And Pollution: More Delhiites Are Considering To Move Out Of The City

She is not alone, Vikash Makkar, a freelance linguist specialist and a journalist, who had been living in Delhi from the last 12 years, moved back to his hometown in Jamshedpur. "Since October with an unplanned journey, I moved to my hometown and have been living there. It is quite relaxed here as compared to Delhi's ongoing pollution crisis that I had faced," he shares.

29-year-old Riya Baibhawi also uprooted from the city. She had been living in Delhi from last 5 years. She is currently living in Ludhiana, Punjab, and her decision to leave city is also affected by the pollution. Though, it was not easy for her. "It was very tough because it was very difficult to find career opportunities with competitive salaries outside Delhi-NCR. It also required a cut down of my social life, which adversely affected my mental health," she says. She shares that one of her friends, who had been living in Noida for the last 20 years had also moved out as pollution exacerbated her asthma.

Another family, who have been living in Delhi's Karol Bagh for more than two decades now are considering moving out of Delhi. "They are looking for properties outside Delhi where air is cleaner," shares their 26-year-old daughter who now lives in her marital home in Noida.

As per a survey by a consumer insights platform Smytten PulseAI, about 34.6% of the residents surveyed in Delhi NCR have considered to move out of the city due to worsening air. A 2023 study published in the International Journal of Environmental Research and Public Health shows that if the level of PM2.5 increases by 10µg/m3, migrants coming into the city will be reduced by 21.2%. While migration in the city has been ongoing, pollution does show some strains of people moving out of the city.

As per the Air Quality Life Index released by the Energy Policy Institute at the University of Chicago (EPIC), the fine particulate matter or PM2.5 in air will shorten an average Indian's life expectancy by 5.3 years, and in Delhi, it could shorten a person's life span by 11.9 years. However, the Union government has said in the parliament that there is "no conclusive national data to establish a direct correlation between deaths or diseases occurring exclusively due to air pollution". This statement comes at a time when doctors themselves noted a surge in cases due to pollution and have urged people to leave the cities.