For those who have not experienced a migraine, perhaps it would seem just another headache. But for someone like me who has suffered through migraines that will last over a week even with medication, I can definitely tell you that it's much more. The ache is not confined to the head; it's the whole experience. Nausea, sensitivity to light, and throbs so bad it makes simple tasks unbearable. It also comes with an emotional burden—the loneliness and frustration are pretty unbearable. Through the years, realizing how hormones are also implicated in triggering and exacerbating my migraines has helped change the game in my dealing with these episodes.

What are Hormonal Migraines?

Hormonal migraines are caused by fluctuations in estrogen and progesterone, the two main female hormones. These hormones are essential for the reproductive system, regulating menstrual cycles and pregnancy. They also have an effect on brain chemicals, such as serotonin and dopamine, which affect mood and pain perception. When hormone levels fluctuate, such as during menstruation, pregnancy, or menopause, they can destabilize the pathways in the brain, causing migraines.

According to Dr. Shivananda Pai, Consultant Neurology, migraines are more than a neurological disorder. "Migraines represent a complex interplay of genetic, environmental, and hormonal factors. In women, hormonal fluctuations are a critical trigger that amplifies sensitivity to pain," he explains. Hormonal headaches are particularly challenging because they are influenced by multiple life stages, from puberty to post-menopause. Common causes include:

• Menstrual periods: Estrogen levels significantly drop just before menstruation often triggers a migraine.
• Pregnancy: Hormones can act to relieve symptoms or aggravate them during different times of pregnancy.
• Menopause: The hormonal fluctuation during menopause can intensify a migraine, while some women tend to find relief.
• Hormonal therapies: Birth control and HRT tend to level off hormone balances in some individuals but will exacerbate a migraine in others.

Complex Role of Hormones in Women’s Neurological Health

Estrogen and Neurological Health

Estrogen, often called the "hormone of femininity", does more than regulate reproductive functions. It is a powerful influencer of brain health. Estrogen modulates the activity of neurotransmitters like serotonin, which regulates mood and pain perception, and dopamine, associated with reward and pleasure.

During stages of hormonal stability, like in pregnancy's latter months, women may have fewer migraines because of the steady elevation of estrogen. However, a sudden downfall in estrogen destabilizes these chemicals in the brain, sending a heightened sensitivity for migraine triggers.

Menstrual Migraines

The most common form of hormonal migraines is menstrual migraines, which occur in response to the steep decline in estrogen levels just before menstruation. These are typically more intense and less responsive to standard treatment. The timing of these migraines provides clear evidence of the role hormones play in neurological health.

Pregnancy and Hormonal Shifts

Pregnancy is a rollercoaster of hormones. Although many women experience relief from migraines as a result of the constantly elevated levels of estrogen, some women, particularly in the first trimester, worsen. This individual variability is a characteristic of hormonal migraine triggers.

Hormonal Therapies and Management of Migraine

Hormonal treatments, such as oral contraceptives and HRT, have had mixed reviews regarding their use in managing migraine. Some women fare better with the stabilization the treatment provides, whereas others suffer worsening symptoms. This will depend on the nature and dose of the hormones used.

Post-Menopause: Migraine Remission or Continued Struggles?

For most women, menopause brings relief from their migraines. The decline in frequency and severity often accompanies stability in hormone levels. Even so, the susceptibility remains with some towards other forms of triggers including stress and sleep deprivation, not to forget diet-related factors and continues the saga of migraines well after the menopausal stages.

Effect on Neurological Health Due to Hormonal Changes

The relationship of hormones to neurological health goes beyond migraines. Hormonal changes have profound effects on a woman's brain in general.

Mood Disorders: Estrogen helps stabilize mood by regulating serotonin. Its decline at menopause increases the risk of mood swings and depression.

Neurodegenerative Diseases: Estrogen is neuroprotective, stimulating the growth and repair of brain cells. Its absence in post-menopausal women has been associated with an increased risk of Alzheimer's disease and cognitive decline.

Multiple Sclerosis (MS): Hormonal cycles may affect the course of MS, a disease that occurs more frequently in women than in men. Estrogen's anti-inflammatory effects provide transient protection during pregnancy, reducing relapse rates in women with MS.

"The intricate interplay between hormones and neurological health underscores the need for gender-specific treatment approaches," says Dr. Pai.

Managing Hormonal Migraines: Practical Strategies

While hormonal changes are inevitable, several strategies can help manage migraines effectively:

1. Tracking Your Cycle

Understanding your menstrual cycle can help identify patterns and predict when migraines might occur. This knowledge allows for preventive measures, such as scheduling medications or adjusting lifestyle habits.

2. Consulting Specialists

Working with a neurologist or gynecologist can help develop a personalized treatment plan. Options might include hormonal therapies, triptans, or preventive medications tailored to your specific needs.

3. Adopting a Healthy Lifestyle

A well-balanced diet, regular exercise, and stress management are all integral parts of managing migraines. For instance, magnesium-rich foods and hydration can help reduce the frequency and severity of attacks.

4. Exploring Preventive Therapies

For people with severe or frequent migraines, preventive medications, such as beta-blockers or CGRP inhibitors, may be prescribed. These medications stabilize brain activity and therefore reduce the chances of migraine during hormonal fluctuations.

5. Mind-Body Techniques

Techniques like yoga, meditation, and biofeedback can enhance wellness and reduce the debilitating effects of stress-one of the most common migraine triggers.

Research that was once in its embryonic stage continues to shed more light on the role of hormones in migraines and other neurological conditions. Further breakthroughs in genetic testing might enable doctors to predict, at least in a way, how an individual would react to hormonal therapies. The importance of gender-specific approaches is gradually being realized, which involves differentiating between the plight of women with migraines from others.

As Dr. Pai puts it, "Empowering women with knowledge about the hormonal underpinnings of migraines can lead to better, more personalized care. With the right strategies, migraines can be effectively managed, allowing women to lead fuller, healthier lives.

Migraines are not headaches; they are a complex neurological condition that deeply impacts the lives of millions of women. Understanding the role of hormones in triggering and exacerbating migraines is a vital step toward better management and relief.

Awareness, proactive care, and advances in medical research can help women regain their lives from the grip of hormonal migraines. Whether tracking cycles, adopting healthier habits, or seeking tailored medical care, every step taken toward understanding and managing migraines is a step toward empowerment.

Dr Shivananda Pai is a Consultant Neurology at KMC Hospital Dr B R Ambedkar Circle in Mangalore, India.

Brandes JL. The Influence of Estrogen on Migraine: A Systematic Review. JAMA. 2006;295(15):1824–1830. doi:10.1001/jama.295.15.1824

Sacco S, Ricci S, Degan D, Carolei A. Migraine in women: the role of hormones and their impact on vascular diseases. J Headache Pain. 2012 Apr;13(3):177-89. doi: 10.1007/s10194-012-0424-y. Epub 2012 Feb 26. PMID: 22367631; PMCID: PMC3311830.

While HPV vaccines are most known for preventing cervical cancer, a top US doctor says they can also help curb the rising incidence of head and neck cancers.

According to Mikkael A. Sekeres, Chief of the Division of Hematology and Professor of Medicine at the Sylvester Comprehensive Cancer Center at the University of Miami, Human papillomavirus (HPV) — the same sexually transmitted virus that can infect the genital area and lead to cervical cancer — is now the greatest risk factor for head and neck cancer.

Writing in The Washington Post, Sekeres noted that HPV accounts for about 30 per cent of oropharyngeal cancer worldwide.

HPV is believed to be responsible for the recent rise in head and neck cancers, which include malignancies affecting the mouth and throat (oral cavity and pharynx), voice box (larynx), sinuses and nasal cavities, and salivary glands.

Sekeres said the US records about 60,000 new cases of head and neck cancers each year, while the global incidence is expected to rise by 30 per cent by 2030.

What Are The Risk Factors?

The expert noted that men develop oral cavity and pharynx cancers at approximately 2.5 times the rate of women.

Major risk factors include:

• Tobacco use, including smoking, secondhand smoke and smokeless tobacco
• Chewing areca nut, also known as betel quid
• Heavy alcohol consumption
• HPV infection

Also read: PM Modi Launches Nationwide Free HPV Vaccination Drive; A Landmark Step, Says WHO

The Centers for Disease Control and Prevention (CDC) estimates that the high-risk HPV subtypes most associated with head and neck cancers are detectable in the mouths of 4 per cent of adults aged 18 to 69.

While a pap test detects early-stage cervical cancer in women, no such test exists for penile, anal, or head and neck cancers in men, which can worsen their survival rate.

HPV Vaccination Best Prevention Strategy

Thus, Sekeres said: “The best way to prevent the most common types of HPV is through vaccination, with two doses of the vaccine recommended for children at age 11 or 12, or starting as early as 9 years and up to age 26 for those who missed it as a child".

He noted that although the vaccine is approved for use up to age 45, it is generally less beneficial after age 26 because many individuals may have already been exposed to HPV. However, doctors can help determine whether vaccination may still be beneficial for adults.

Earlier this year, the European Cancer Organization also urged broader HPV vaccination regardless of gender.

“HPV affects everyone, regardless of gender. It can lead to cancers of the cervix, mouth and throat, anus and penis. This is why universal protection is so important,” the organization said in a social media post.

Read More: Who Needs HPV Vaccine? Guide For Every Parent, Teen And Adult

HPV Vaccine Can Boost Cancer Risk

A 2026 study published in JAMA Oncology found that boys and men who received the HPV vaccine between the ages of 9 and 26 were nearly 50 per cent less likely to develop cancers of the head and neck, esophagus, anus, or penis.

The findings, based on data of more than 510,000 boys and men, highlight the importance of vaccinating all children and adolescents against HPV, said Taito Kitano, first author of the study and a researcher at Nara Prefecture General Medical Center in Japan.

“Children, adolescents, parents and health care workers should be more informed about the expected benefits of the HPV vaccine, not just cervical cancer,” Kitano said.

UK-based journalist Emma Barnett said it took 21 years to receive a diagnosis of endometriosis, a chronic condition in which tissue similar to the uterine lining grows outside the womb.

The condition, which causes severe pain and other complications, affects one in 10 women. However, diagnosis remains difficult and is often dismissed as merely “painful periods”.

“It’s a disease that has outwitted doctors and researchers around the world. No one knows what causes it. No one knows how to cure it. At least 1 in 10 women are staggering about with it,” Barnett shared in a post on Instagram.

“Endometriosis may not typically kill women, but it’s a living death for many. It is a silent medical emergency,” she added.

The 41-year-old BBC journalist said: “It’s a scandal it takes nearly 10 years to be diagnosed — in my case 21 years.”

Living With Debilitating Pain

Also read: This Is Endometriosis, A Short Film On Debilitating Health Condition Wins BAFTA Award 2026, Know More

There is currently no cure for endometriosis. Available treatments include hormone therapy, predominantly the contraceptive pill, to manage symptoms, or surgery, including hysterectomy in severe cases.

“I’ve been suffering from the condition — in which tissue similar to the womb lining, that’s meant to leave your body, grows and builds outside the uterus — since my periods started at the age of 10. But it would be more than 20 years until I’d be diagnosed at 31, after two years of trying to get pregnant naturally, which meant more than 20 years of enduring excruciating, bone-grinding pain without ever having a label for it,” she wrote in Women's Health magazine.

She described the pain “as a drilling sensation from my pelvis that travels down my legs — making them feel as though I can’t lift them to go up the stairs. Sometimes, the hurt spreads to my arms or chest, and comes with crippling nausea and loss of appetite. I also run cold; freezing even. It’s like someone turned the heating off in my body”.

A Documentary To Expose A Neglected Disease

Read More: Amy Schumer Opens Up On Side Effects After “Botched” Colonoscopy And Weight Loss Journey

Recognizing that many women experience similar struggles, Barnett made a new documentary film "Emma Barnett: Fighting Endometriosis" in which she speaks with women, including doctors, researchers and even politicians about their experiences with endometriosis, highlighting a neglected disease that has no known cure.

Through the documentary, Barnett hopes to raise awareness of the condition, improve public understanding, and draw attention to the long delays many women face in receiving a diagnosis.

“One of the reasons I have made a film about endometriosis is that I want people to understand it is not just ‘painful periods’. It’s a system-wide inflammatory condition where tissue similar to the lining of the uterus grows outside of it, causing agonizing pain. I am hoping to boost public understanding of that, and beyond merely being able to pronounce it,” she wrote in The Independent.

“It’s very hard to make something invisible visible, but what I am trying to do with this film is bring the invisible into light and show that this is a silent emergency.”

IVF is often regarded as a medical milestone defined by protocols, cycles, and success rates. Over time, it has also come to be understood in a more holistic way, where clinical care and patient experience carry equal significance.

This is especially relevant today, as many patients begin IVF while managing demanding work environments, prolonged screen exposure, and irregular rest patterns. Given how closely reproductive health is linked to hormonal balance, lifestyle naturally becomes part of the broader care context. Which is why IVF care today is not only about clinical precision and outcomes, but equally about how supported, steady, and manageable the overall patient experience feels.

Here are ways to improve the IVF patient experience:

• Establish clear boundaries between work and rest

• Be mindful of screen exposure, particularly in the evening

Evening screen exposure can interfere with melatonin production, affecting sleep quality. Reducing screen time before bed and allowing a wind-down period helps regulate sleep cycles and supports hormonal stability during treatment.

• Managing Injection Fatigue With Needle-Free Injections

A standard IVF cycle involves a series of hormone injections administered over a defined timeline. Depending on the protocol, this can range from 20 to 40 injections in a single cycle. In India, where an estimated 300,000 to 350,000 IVF cycles are performed annually, this represents a significant physical and emotional load for patients. While these injections are necessary, it can be helpful to explore less invasive options such as needle-free injection systems. These systems use controlled pressure to deliver medication without a needle and may help reduce some of the discomfort associated with repeated injections. During IVF treatments, N-FIS, the needle-free injection device, has, in my observation, helped transform patient experience substantially.

Using the latest technological developments in drug delivery has eased the overall treatment experience completely; it has helped patients stay more comfortable and consistent throughout the IVF journey.

• Prioritize consistent and restorative sleep

Sleep plays a direct role in hormonal regulation and recovery. During IVF, maintaining a regular sleep schedule becomes particularly important.

It is not only about getting enough hours of sleep, but also about maintaining rhythm and quality. A calm pre-sleep routine and a stable sleep environment can help the body respond better to treatment.

• Maintain simple, sustainable daily habits

IVF does not require extreme lifestyle changes. It responds better to consistency than intensity. Light physical activity, such as walking or yoga, can help manage stress and support circulation. A balanced diet and adequate hydration further help the body maintain stability through hormonal changes.

The focus should remain on habits that are realistic to sustain, not idealized routines that are difficult to maintain under stress.

IVF is a medically intensive process, but for patients, it is also a deeply personal one that unfolds alongside everyday responsibilities.

Improving the experience does not always require large interventions. Often, it comes from small, practical adjustments that reduce strain, support routine, and help patients move through the journey with greater steadiness and less fatigue.