For those who have not experienced a migraine, perhaps it would seem just another headache. But for someone like me who has suffered through migraines that will last over a week even with medication, I can definitely tell you that it's much more. The ache is not confined to the head; it's the whole experience. Nausea, sensitivity to light, and throbs so bad it makes simple tasks unbearable. It also comes with an emotional burden—the loneliness and frustration are pretty unbearable. Through the years, realizing how hormones are also implicated in triggering and exacerbating my migraines has helped change the game in my dealing with these episodes.

What are Hormonal Migraines?

Hormonal migraines are caused by fluctuations in estrogen and progesterone, the two main female hormones. These hormones are essential for the reproductive system, regulating menstrual cycles and pregnancy. They also have an effect on brain chemicals, such as serotonin and dopamine, which affect mood and pain perception. When hormone levels fluctuate, such as during menstruation, pregnancy, or menopause, they can destabilize the pathways in the brain, causing migraines.

According to Dr. Shivananda Pai, Consultant Neurology, migraines are more than a neurological disorder. "Migraines represent a complex interplay of genetic, environmental, and hormonal factors. In women, hormonal fluctuations are a critical trigger that amplifies sensitivity to pain," he explains. Hormonal headaches are particularly challenging because they are influenced by multiple life stages, from puberty to post-menopause. Common causes include:

• Menstrual periods: Estrogen levels significantly drop just before menstruation often triggers a migraine.
• Pregnancy: Hormones can act to relieve symptoms or aggravate them during different times of pregnancy.
• Menopause: The hormonal fluctuation during menopause can intensify a migraine, while some women tend to find relief.
• Hormonal therapies: Birth control and HRT tend to level off hormone balances in some individuals but will exacerbate a migraine in others.

Complex Role of Hormones in Women’s Neurological Health

Estrogen and Neurological Health

Estrogen, often called the "hormone of femininity", does more than regulate reproductive functions. It is a powerful influencer of brain health. Estrogen modulates the activity of neurotransmitters like serotonin, which regulates mood and pain perception, and dopamine, associated with reward and pleasure.

During stages of hormonal stability, like in pregnancy's latter months, women may have fewer migraines because of the steady elevation of estrogen. However, a sudden downfall in estrogen destabilizes these chemicals in the brain, sending a heightened sensitivity for migraine triggers.

Menstrual Migraines

The most common form of hormonal migraines is menstrual migraines, which occur in response to the steep decline in estrogen levels just before menstruation. These are typically more intense and less responsive to standard treatment. The timing of these migraines provides clear evidence of the role hormones play in neurological health.

Pregnancy and Hormonal Shifts

Pregnancy is a rollercoaster of hormones. Although many women experience relief from migraines as a result of the constantly elevated levels of estrogen, some women, particularly in the first trimester, worsen. This individual variability is a characteristic of hormonal migraine triggers.

Hormonal Therapies and Management of Migraine

Hormonal treatments, such as oral contraceptives and HRT, have had mixed reviews regarding their use in managing migraine. Some women fare better with the stabilization the treatment provides, whereas others suffer worsening symptoms. This will depend on the nature and dose of the hormones used.

Post-Menopause: Migraine Remission or Continued Struggles?

For most women, menopause brings relief from their migraines. The decline in frequency and severity often accompanies stability in hormone levels. Even so, the susceptibility remains with some towards other forms of triggers including stress and sleep deprivation, not to forget diet-related factors and continues the saga of migraines well after the menopausal stages.

Effect on Neurological Health Due to Hormonal Changes

The relationship of hormones to neurological health goes beyond migraines. Hormonal changes have profound effects on a woman's brain in general.

Mood Disorders: Estrogen helps stabilize mood by regulating serotonin. Its decline at menopause increases the risk of mood swings and depression.

Neurodegenerative Diseases: Estrogen is neuroprotective, stimulating the growth and repair of brain cells. Its absence in post-menopausal women has been associated with an increased risk of Alzheimer's disease and cognitive decline.

Multiple Sclerosis (MS): Hormonal cycles may affect the course of MS, a disease that occurs more frequently in women than in men. Estrogen's anti-inflammatory effects provide transient protection during pregnancy, reducing relapse rates in women with MS.

"The intricate interplay between hormones and neurological health underscores the need for gender-specific treatment approaches," says Dr. Pai.

Managing Hormonal Migraines: Practical Strategies

While hormonal changes are inevitable, several strategies can help manage migraines effectively:

1. Tracking Your Cycle

Understanding your menstrual cycle can help identify patterns and predict when migraines might occur. This knowledge allows for preventive measures, such as scheduling medications or adjusting lifestyle habits.

2. Consulting Specialists

Working with a neurologist or gynecologist can help develop a personalized treatment plan. Options might include hormonal therapies, triptans, or preventive medications tailored to your specific needs.

3. Adopting a Healthy Lifestyle

A well-balanced diet, regular exercise, and stress management are all integral parts of managing migraines. For instance, magnesium-rich foods and hydration can help reduce the frequency and severity of attacks.

4. Exploring Preventive Therapies

For people with severe or frequent migraines, preventive medications, such as beta-blockers or CGRP inhibitors, may be prescribed. These medications stabilize brain activity and therefore reduce the chances of migraine during hormonal fluctuations.

5. Mind-Body Techniques

Techniques like yoga, meditation, and biofeedback can enhance wellness and reduce the debilitating effects of stress-one of the most common migraine triggers.

Research that was once in its embryonic stage continues to shed more light on the role of hormones in migraines and other neurological conditions. Further breakthroughs in genetic testing might enable doctors to predict, at least in a way, how an individual would react to hormonal therapies. The importance of gender-specific approaches is gradually being realized, which involves differentiating between the plight of women with migraines from others.

As Dr. Pai puts it, "Empowering women with knowledge about the hormonal underpinnings of migraines can lead to better, more personalized care. With the right strategies, migraines can be effectively managed, allowing women to lead fuller, healthier lives.

Migraines are not headaches; they are a complex neurological condition that deeply impacts the lives of millions of women. Understanding the role of hormones in triggering and exacerbating migraines is a vital step toward better management and relief.

Awareness, proactive care, and advances in medical research can help women regain their lives from the grip of hormonal migraines. Whether tracking cycles, adopting healthier habits, or seeking tailored medical care, every step taken toward understanding and managing migraines is a step toward empowerment.

Dr Shivananda Pai is a Consultant Neurology at KMC Hospital Dr B R Ambedkar Circle in Mangalore, India.

Brandes JL. The Influence of Estrogen on Migraine: A Systematic Review. JAMA. 2006;295(15):1824–1830. doi:10.1001/jama.295.15.1824

Sacco S, Ricci S, Degan D, Carolei A. Migraine in women: the role of hormones and their impact on vascular diseases. J Headache Pain. 2012 Apr;13(3):177-89. doi: 10.1007/s10194-012-0424-y. Epub 2012 Feb 26. PMID: 22367631; PMCID: PMC3311830.

On February 13, Canadians across the country mark Wear Red Canada Day, a reminder that heart disease remains the leading cause of death for women. Yet despite the scale of the problem, many women still do not recognize their risk or their symptoms.

“We’re learning more and more each day about how heart disease uniquely affects women,” said nurse practitioner and researcher Rachel Ollivier in an interview with CTV News. She emphasized that awareness is still lagging, both among patients and within health-care systems.

According to the World Health Organization, cardiovascular disease accounts for roughly one in three deaths among women globally. In Canada, heart disease and stroke continue to be leading causes of death among women, and women are less likely than men to receive timely diagnosis or treatment.

Symptoms Can Look Different

Chest pain remains the most common heart attack symptom in both men and women. But Ollivier explained that women’s symptoms can often be subtler or feel different.

“For women, they often uniquely experience chest pain that seems like more of a discomfort or a tightness in the chest,” she said. Some women may feel pain in the left arm or jaw, unusual fatigue, nausea, vomiting, or discomfort between the shoulder blades.

Because these symptoms can be less specific, they are sometimes dismissed as stress, anxiety, indigestion, or exhaustion. Social factors also play a role. Women often juggle multiple responsibilities at home and work, and may delay seeking care. In some cases, their concerns may also be minimized within health-care settings.

Medical differences matter too. Women typically have smaller hearts and arteries, and plaque buildup behaves differently compared to men. Conditions such as spontaneous coronary artery dissection and microvascular dysfunction are seen more commonly in women, making diagnosis more complex.

Hormones and the Hidden Risk Window

Beyond symptoms, experts are urging greater recognition of the role hormones play in lifelong heart health.

“Endogenous estrogen is cardio protective,” Ollivier explained. As women enter the perimenopausal transition, estrogen levels fluctuate and gradually decline, and that protection is lost. This shift can lead to higher cholesterol levels and changes in fat distribution, increasing cardiovascular risk, particularly between the ages of 40 and 60.

Colleen Norris, a nursing professor at the University of Alberta and research lead of the CKHui LHHW Women’s Heart Health Research Collaborative who wrote on Yahoo Canada, believes the conversation needs to go even deeper.

She argues that ovaries have long been viewed only through the lens of reproduction. “The ovaries are not just reproductive organs. They are architects of women’s health across the lifespan,” she noted. Estrogen influences the heart and blood vessels, but also the brain, bones, kidneys, metabolism, and immune function.

Most women are never told that ovarian reserve and estrogen levels begin declining in their late 30s. By the time noticeable symptoms appear, biological changes may have already been underway for years.

Menopause itself is just one day, Norris explained. The larger reproductive transition surrounding it is what significantly increases vulnerability to chronic disease. Yet the health-care system often waits until disease develops before intervening.

Moving From Awareness to Action

Both experts stress that education is critical. Women with conditions such as polycystic ovary syndrome, pregnancy complications like preeclampsia or gestational diabetes, and those entering midlife should be particularly mindful of their cardiovascular risk.

Wear Red Canada Day is meant to spark awareness, but symbols alone are not enough. Experts are calling for better research funding focused on midlife women, improved medical education around ovarian aging, and more proactive screening during the reproductive transition.

Heart disease in women is not inevitable. But recognizing that symptoms can differ, and that hormonal shifts matter, could be lifesaving.

Seychelles Chikungunya Virus Outbreak: The United States warned travelers to be careful if they plan to visit the Seychelles islands anytime soon as it is currently undergoing a chikungunya outbreak. As per the Centers for Disease Control and Prevention (CDC), a 'Level 2' advisory for the island has been issued and travelers have been asked to 'practice enhanced precautions' if they do plan to visit.

Unique Symptoms Of Chikungunya: What Is The Disease?

Chikungunya is a mosquito-borne viral disease transmitted primarily by Aedes aegypti and Aedes albopictus, the same mosquitoes that spread dengue fever. Symptoms typically appear three to seven days after a bite and include sudden fever, severe joint pain, headache, nausea, fatigue, and rash in about half of cases.

However, there are certain unique symptoms of chikungunya. For instance, unlike a Dengue fever, chikungunya leaves lingering effects along with joint pain and fatigue that lasts up to weeks.

Unique Symptoms of Chikungunya: What Are They?

While common symptoms like high fever often >102 degree F is common there are other symptoms too, which includes:

• Headache
• Muscle pain
• Fatigue
• Joint Swelling

• Some unique symptoms of this disease includes neurological complications such as rare instances that could lead to encephalitis or the inflammation of the brain, meningitis, or severe nerve issues like Guillain-Barré syndrome.

• Ocular symptoms include red eyes like conjunctivitis, eye pain, or temporary vision problems.

• Unique symptoms could also include bleeding, while it is more common in Dengue, rare bleeding from gums and nose could occur in Chikungunya.

• Other unique symptoms may include chronic and persistent symptoms like joint pain that does not subside after the initial week and lasts for months or even years.

• Other symptoms include cardiovascular and respiratory issues and skin manifestation, which could go beyond the common rash. Some patients may experience vasculitis-like skin lesions.

Unique Symptoms of Chikungunya: How Long Does It Last?

Chikungunya symptoms usually occur with in 3 to 7 days after a bite. However, the symptoms could often last long. While fever could subside in a day or two, chronic symptoms especially like joint pain and muscle pain could last for months. Weakness too could persist.

Unique Symptoms Of Chikungunya: Outbreak In Seychelles Led To US Issuing Travel Advisory

A Level 2 travel advisory has been issued, which means the travelers are expected to practice enhanced precautions as compared to a Level 1 advisory that only asks travelers to practice usual precautions.

In more serious cases, Level 3 advisory is issued that asks travelers to reconsider non-essential travel, whereas a Level 4 advisory asks travelers to avoid all travel.

Read: CDC Travel Advisory Issued For These Islands Amid Chikungunya Outbreak

As CDC issues travel advisory, here is what travelers are expected to do:

• Travelers are expected to protect themselves by preventing mosquito bites, which includes using insect repellent, wearing long-sleeved shirts and pants, and staying in places where air conditioning or that have screens on the windows and doors
• The CDC also tells travelers to get vaccinated for those who are visiting the area affected by a chikungunya outbreak
• If a traveler is pregnant, they are asked to reconsider travel to affected area, especially if they are closed to delivering their baby. Mothers infected around the time of delivery can pass the virus to their baby before or during delivery. Newborns infected in this way or by a mosquito bite are at risk for severe illness, including poor long-term outcomes
• If someone has a fever, joint pain, headache, muscle pain, joint swelling, or rash during or after the travel, they must seek medical care

Why do some relationships feel effortless and magnetic, while others slowly unravel despite our best intentions? According to neuroscientist Andrew Huberman, the answers lie deep within our early childhood experiences and the intricate wiring of the brain.

In a recent episode of Huberman Lab titled “Essentials: The Science of Love, Desire & Attachment,” Huberman explores how biology and psychology work together to shape the way we connect, commit, and sometimes drift apart. What makes the conversation compelling is how it bridges hard science with very human emotions.

Our First Bonds Shape Our Love Stories

Huberman begins with a powerful idea: the way we love as adults often echoes how we were loved as children.

He refers to the landmark “Strange Situation” experiment by psychologist Mary Ainsworth. In this study, toddlers were briefly separated from their caregivers and then reunited. Researchers closely observed how the children reacted. Some felt secure and soothed upon return. Others were anxious, avoidant, or distressed.

These early attachment patterns, Huberman explains, frequently resurface in adult romantic relationships. A securely attached child may grow into a partner who trusts and communicates well. An anxious child may become someone who fears abandonment. An avoidant child may struggle with emotional closeness.

The hopeful part? These patterns are not destiny. Awareness allows change. Once people recognize their emotional blueprint, they can reshape it.

Love Is Not in One Spot in the Brain

Romantic connection is not housed in a single “love center.” Instead, multiple brain regions activate in sequence to create desire, attraction, empathy, and long term bonding.

Huberman clears up a common myth about dopamine. Many people think of it as the pleasure chemical. In reality, it is more about motivation and pursuit. Dopamine fuels craving and drives us toward a person we find compelling. It is the chemical that makes you check your phone, wait for a message, or feel a rush at the thought of someone.

But desire alone does not sustain love.

For deeper attachment, empathy circuits come into play. The prefrontal cortex and the insula are especially important. The insula helps us sense our internal bodily state, a process known as interoception. It allows us to feel our own emotions while tuning into someone else’s. This shared emotional awareness strengthens bonds.

The Role of “Positive Delusion”

One of the most fascinating ideas Huberman discusses is what he calls “positive delusion.” For long term stability, the brain benefits from believing that your partner is uniquely special. This slight bias, almost a romantic illusion, reinforces commitment.

It is not about ignoring flaws. It is about genuinely feeling that this person, out of billions, holds a singular place in your emotional world. Biologically, this strengthens attachment pathways.

Why Relationships Fall Apart

Huberman also references research from the Gottman Lab at the University of Washington. Decades of data reveal four behaviors that predict relationship breakdown: criticism, defensiveness, stonewalling, and contempt.

Stonewalling happens when one partner emotionally withdraws and stops responding. But the most toxic behavior is contempt. Researchers have described it as acid to a relationship because it corrodes trust and shuts down empathy. Once contempt takes root, the neural circuits that support connection begin to weaken.

In the end, love is both chemistry and choice. Our brains may set the stage, but awareness, empathy, and daily behavior determine whether attachment deepens or quietly falls away.