Migraines In Women: How Hormones Influence Neurological Health
For those who have not experienced a migraine, perhaps it would seem just another headache. But for someone like me who has suffered through migraines that will last over a week even with medication, I can definitely tell you that it's much more. The ache is not confined to the head; it's the whole experience. Nausea, sensitivity to light, and throbs so bad it makes simple tasks unbearable. It also comes with an emotional burden—the loneliness and frustration are pretty unbearable. Through the years, realizing how hormones are also implicated in triggering and exacerbating my migraines has helped change the game in my dealing with these episodes.
Hormonal migraines are caused by fluctuations in estrogen and progesterone, the two main female hormones. These hormones are essential for the reproductive system, regulating menstrual cycles and pregnancy. They also have an effect on brain chemicals, such as serotonin and dopamine, which affect mood and pain perception. When hormone levels fluctuate, such as during menstruation, pregnancy, or menopause, they can destabilize the pathways in the brain, causing migraines.
According to Dr. Shivananda Pai, Consultant Neurology, migraines are more than a neurological disorder. "Migraines represent a complex interplay of genetic, environmental, and hormonal factors. In women, hormonal fluctuations are a critical trigger that amplifies sensitivity to pain," he explains. Hormonal headaches are particularly challenging because they are influenced by multiple life stages, from puberty to post-menopause. Common causes include:
Estrogen, often called the "hormone of femininity", does more than regulate reproductive functions. It is a powerful influencer of brain health. Estrogen modulates the activity of neurotransmitters like serotonin, which regulates mood and pain perception, and dopamine, associated with reward and pleasure.
During stages of hormonal stability, like in pregnancy's latter months, women may have fewer migraines because of the steady elevation of estrogen. However, a sudden downfall in estrogen destabilizes these chemicals in the brain, sending a heightened sensitivity for migraine triggers.
The most common form of hormonal migraines is menstrual migraines, which occur in response to the steep decline in estrogen levels just before menstruation. These are typically more intense and less responsive to standard treatment. The timing of these migraines provides clear evidence of the role hormones play in neurological health.
Pregnancy is a rollercoaster of hormones. Although many women experience relief from migraines as a result of the constantly elevated levels of estrogen, some women, particularly in the first trimester, worsen. This individual variability is a characteristic of hormonal migraine triggers.
Hormonal treatments, such as oral contraceptives and HRT, have had mixed reviews regarding their use in managing migraine. Some women fare better with the stabilization the treatment provides, whereas others suffer worsening symptoms. This will depend on the nature and dose of the hormones used.
For most women, menopause brings relief from their migraines. The decline in frequency and severity often accompanies stability in hormone levels. Even so, the susceptibility remains with some towards other forms of triggers including stress and sleep deprivation, not to forget diet-related factors and continues the saga of migraines well after the menopausal stages.
The relationship of hormones to neurological health goes beyond migraines. Hormonal changes have profound effects on a woman's brain in general.
Mood Disorders: Estrogen helps stabilize mood by regulating serotonin. Its decline at menopause increases the risk of mood swings and depression.
Neurodegenerative Diseases: Estrogen is neuroprotective, stimulating the growth and repair of brain cells. Its absence in post-menopausal women has been associated with an increased risk of Alzheimer's disease and cognitive decline.
Multiple Sclerosis (MS): Hormonal cycles may affect the course of MS, a disease that occurs more frequently in women than in men. Estrogen's anti-inflammatory effects provide transient protection during pregnancy, reducing relapse rates in women with MS.
"The intricate interplay between hormones and neurological health underscores the need for gender-specific treatment approaches," says Dr. Pai.
While hormonal changes are inevitable, several strategies can help manage migraines effectively:
Understanding your menstrual cycle can help identify patterns and predict when migraines might occur. This knowledge allows for preventive measures, such as scheduling medications or adjusting lifestyle habits.
Working with a neurologist or gynecologist can help develop a personalized treatment plan. Options might include hormonal therapies, triptans, or preventive medications tailored to your specific needs.
A well-balanced diet, regular exercise, and stress management are all integral parts of managing migraines. For instance, magnesium-rich foods and hydration can help reduce the frequency and severity of attacks.
For people with severe or frequent migraines, preventive medications, such as beta-blockers or CGRP inhibitors, may be prescribed. These medications stabilize brain activity and therefore reduce the chances of migraine during hormonal fluctuations.
Techniques like yoga, meditation, and biofeedback can enhance wellness and reduce the debilitating effects of stress-one of the most common migraine triggers.
Research that was once in its embryonic stage continues to shed more light on the role of hormones in migraines and other neurological conditions. Further breakthroughs in genetic testing might enable doctors to predict, at least in a way, how an individual would react to hormonal therapies. The importance of gender-specific approaches is gradually being realized, which involves differentiating between the plight of women with migraines from others.
As Dr. Pai puts it, "Empowering women with knowledge about the hormonal underpinnings of migraines can lead to better, more personalized care. With the right strategies, migraines can be effectively managed, allowing women to lead fuller, healthier lives.
Migraines are not headaches; they are a complex neurological condition that deeply impacts the lives of millions of women. Understanding the role of hormones in triggering and exacerbating migraines is a vital step toward better management and relief.
Awareness, proactive care, and advances in medical research can help women regain their lives from the grip of hormonal migraines. Whether tracking cycles, adopting healthier habits, or seeking tailored medical care, every step taken toward understanding and managing migraines is a step toward empowerment.
Dr Shivananda Pai is a Consultant Neurology at KMC Hospital Dr B R Ambedkar Circle in Mangalore, India.
Brandes JL. The Influence of Estrogen on Migraine: A Systematic Review. JAMA. 2006;295(15):1824–1830. doi:10.1001/jama.295.15.1824
Sacco S, Ricci S, Degan D, Carolei A. Migraine in women: the role of hormones and their impact on vascular diseases. J Headache Pain. 2012 Apr;13(3):177-89. doi: 10.1007/s10194-012-0424-y. Epub 2012 Feb 26. PMID: 22367631; PMCID: PMC3311830.
Credits: Wikimedia Commons
In his new autobiography Heartbeats, Björn Borg strips away the icy façade that once defined him on court. The book, set for U.S. release on 23 September by Diversion Books, begins with a raw account of his 1990s hospitalization after overdosing on “alcohol, drugs, pills, my preferred ways of self-medication.” It ends with a prostate cancer diagnosis, which he now faces in remission.
“It’s good,” the 69-year-old told The Associated Press in a recent video interview from his Stockholm home, “to have a good beginning and a good ending.” The 292-page memoir is a departure from the silence he cultivated during and after his playing days, offering stories of love, regret, excess and survival.
Borg retired shockingly early, at just 25, after losing both the Wimbledon and U.S. Open finals in 1981 to his rival John McEnroe. While others saw a glittering career still ahead, Borg knew otherwise.
“My head was spinning,” he said. “And I knew I’m going to step away from tennis.”
That decision, he explains, left him unmoored. He returned briefly to the professional circuit in the early 1990s but never again at Grand Slam level. What followed was a long descent into substance abuse.
On court, Borg was famously known as “Ice-Borg”, a man of composure who never flinched. But he reveals that this restraint was a learned skill, born from shame as a 12-year-old banned by his local club for bad behavior.
Off court, that discipline dissolved. By his own account, panic attacks and depression pushed him into cocaine use starting in 1982. “The first time I tried cocaine,” Borg writes, “I got the same kind of rush I used to get from tennis.”
The rush quickly became reliance. “It really destroys you,” Borg said of drugs. “I was happy to get away from tennis, to get away from that life. But I had no plan what to do. I had no people behind me to guide me in the right direction.”
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Borg details two overdoses that landed him in hospital, one in Holland in the early 1990s, and another in 1989 in Milan, which he insists was an accident rather than a suicide attempt. The darkest moment, he admits, came when he awoke in a hospital bed to see his father looking down at him.
“That was the worst shame of all,” he writes.
These incidents, combined with spiraling personal struggles, forced Borg to confront how far he had fallen from the grace of his early sporting stardom.
Heartbeats is not a typical sports autobiography. Alongside harrowing stories of addiction and recovery, Borg mixes in extraordinary encounters: a water-skiing shoulder injury before the 1977 U.S. Open, receiving death threats during the 1981 U.S. Open, being robbed at gunpoint after accepting payment in cash, and facing coin-throwing spectators in Rome.
The book name-drops Donald Trump, Nelson Mandela, Tina Turner, Andy Warhol, Yasser Arafat, and even “my old friend Hugh Hefner.” These anecdotes place Borg not only in tennis history but within a swirl of 20th-century celebrity and politics.
“People will be very surprised what really happened,” Borg said. “For me to come out after all these years, all I went through, I went through some difficult times, it’s a relief for me to do this book. I feel so much better. No secrets anymore.”
The memoir also traces his strained relationships, with parents, with his children, and with his own sense of identity after leaving professional sport. By his account, retirement robbed him of purpose, and drugs filled the void.
Borg acknowledges that his descent was partly a reaction to the structure of his tennis life: “I was happy to get away from tennis … but I had no plan what to do.” Without the rhythm of tournaments and training, he spiraled.
Yet he insists he has rebuilt his life. Now, after cancer treatment, he says he is proud of where he stands: sober, reflective, and still connected to the sport he once dominated.
For Borg, writing Heartbeats is as much about catharsis as it is about record-keeping. He admits that his privacy once shielded him from scrutiny but also kept him trapped in silence about his struggles. Now, at 69, he frames his story differently: beginning with a near-death overdose, ending with cancer remission, and filling the middle with unvarnished honesty.
“I went through some difficult times,” he said, “but now I feel so much better.”
Björn Borg’s memoir offers not just the tale of a tennis great, but a portrait of a man forced to confront addiction, shame, and mortality, and who, at last, seems at peace.
(Credit- Canva)
Could daily cocoa extract supplements help fight aging and heart disease? A new study from the COcoa Supplement and Multivitamin Outcomes Study (COSMOS) suggests they might. Researchers from Mass General Brigham found that a key marker for inflammation decreased in people taking a daily cocoa supplement. This finding may help explain how cocoa extract protects the heart.
You may be familiar with cocoa as it is the key ingredient in making one of the most popular sweet treat, chocolate. The debate regarding chocolate and whether it is actually healthy or not is something that has been happening for years. While experts and studies show that dark chocolate can be considered a heart healthy food, the sugar content in it is counterproductive as well.
So, could its supplements be the real answer? The researchers looked into how cocoa extract supplements could help our heart as well as slow down biological aging.
In the new study, researchers looked at blood samples from nearly 600 participants in the COSMOS trial. They wanted to see if the cocoa supplement changed five specific markers of inflammation.
They found that one key marker, called hsCRP, dropped significantly in people who took the cocoa supplement. This marker is important because high levels are linked to a higher risk of heart disease. The levels of hsCRP went down by 8.4% each year compared to people who took a placebo (a fake pill).
This finding helps explain an earlier result from the same trial. In 2022 trial done by COSMOS, the researchers found that cocoa extract supplements reduced deaths from cardiovascular disease by an impressive 27%. The researchers believe that by lowering inflammation, the cocoa extract helped protect the participants' hearts.
While these results are very promising, the researchers stressed that taking a cocoa supplement is not a magic bullet and can't replace a healthy lifestyle. They also noted some interesting side effects, like a small increase in another immune-related marker, which they plan to study more closely in the future.
The findings highlight the importance of eating a diet rich in plant-based foods, especially those with flavanols. The research team hopes this study encourages people to focus on a "diverse, colorful, plant-based diet" to support their heart health as they age.
Dark chocolate may be good for your heart. Studies suggest that eating it could lower your risk of high blood pressure and may help prevent blood clots. It's also been linked to a reduced risk of other heart-related problems like heart failure, stroke, and high cholesterol. These benefits come from special plant compounds in chocolate called flavanols, which help improve blood flow and reduce inflammation.
While many people hope chocolate is a miracle food, the evidence is still mixed. A review of several studies found that chocolate only had a clear positive effect on triglycerides, a type of fat in your blood. For other health areas like skin health, blood sugar, and mental function, the studies didn't find a significant difference between people who ate chocolate and those who didn't. These studies were generally short, so more research is needed.
Chocolate has been enjoyed for centuries and is rich in healthy compounds. However, the most promising health benefits appear to be for heart health, particularly when consuming moderate amounts of dark chocolate that is rich in flavanols. For other health benefits, we need more long-term studies to know for sure.
Credits: Canva
If you have recently had a skin cancer screening, your doctor may have suggested adding a daily vitamin B3 supplement to your routine. A new study highlights that nicotinamide, a form of vitamin B3 available over the counter, could help reduce the risk of certain skin cancers. But what exactly is this vitamin, and why is it sometimes recommended for skin health? Let’s take a closer look.
Niacinamide, also known as nicotinamide, is a form of vitamin B3. It naturally occurs in foods such as meat, fish, milk, eggs, green vegetables, and cereals. In the body, it supports the normal function of fats and sugars while helping to maintain healthy cells. When niacin (another form of vitamin B3) is consumed in larger amounts than needed, it is converted into niacinamide. Unlike niacin, however, niacinamide does not lower cholesterol, as per Healthline.
It’s important not to confuse niacinamide with other related compounds such as niacin, NADH, nicotinamide riboside, inositol nicotinate, or L-tryptophan, as these differ in function and effect.
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For the skin, niacinamide offers several benefits. It strengthens the skin barrier, boosts hydration, calms inflammation and redness, reduces hyperpigmentation and dark spots, minimises pore size, and provides antioxidant protection against free radicals and UV damage. It also supports the production of ceramides and keratin, both of which are essential for skin health.
Beyond skin benefits, niacinamide is used to prevent vitamin B3 deficiency and conditions like pellagra. It has also been studied in relation to acne, diabetes, osteoarthritis, and skin ageing, though scientific evidence is limited for many of these uses.
Nicotinamide, a form of vitamin B3, is often recommended by dermatologists for patients who have undergone skin cancer treatment. It has been shown to protect cells against UV-related damage, a major factor in skin cancer development.
A recent study published in JAMA Dermatology followed nearly 34,000 U.S. veterans and found that nicotinamide supplementation was associated with a lower risk of non-melanoma skin cancers in individuals with a prior history of the disease. The greatest benefit was observed among those who began taking the supplement after their first skin cancer diagnosis. Participants who took 500 mg of nicotinamide twice daily for at least a month had a 54% reduced risk of developing another skin cancer compared with those who did not supplement. “I was very surprised at the degree of risk reduction,” said study author Dr. Lee Wheless of Vanderbilt University Medical Center and the Tennessee Valley Healthcare System VA Medical Center.
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Vitamin B3 is also widely used in skincare products such as cleansers, serums, and moisturisers, where it is marketed for improving tone and texture. While these topical applications may offer cosmetic benefits, the study emphasizes that their effect on cancer prevention remains unclear.
Although nicotinamide is available over the counter, experts advise caution. It’s important to inform your doctor and pharmacist before starting supplementation, especially if you already take prescription medicines, herbal remedies, or other vitamins. Because multivitamin products often combine several ingredients, reviewing them with a healthcare provider helps ensure there are no harmful interactions.
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