Migraines In Women: How Hormones Influence Neurological Health
For those who have not experienced a migraine, perhaps it would seem just another headache. But for someone like me who has suffered through migraines that will last over a week even with medication, I can definitely tell you that it's much more. The ache is not confined to the head; it's the whole experience. Nausea, sensitivity to light, and throbs so bad it makes simple tasks unbearable. It also comes with an emotional burden—the loneliness and frustration are pretty unbearable. Through the years, realizing how hormones are also implicated in triggering and exacerbating my migraines has helped change the game in my dealing with these episodes.
Hormonal migraines are caused by fluctuations in estrogen and progesterone, the two main female hormones. These hormones are essential for the reproductive system, regulating menstrual cycles and pregnancy. They also have an effect on brain chemicals, such as serotonin and dopamine, which affect mood and pain perception. When hormone levels fluctuate, such as during menstruation, pregnancy, or menopause, they can destabilize the pathways in the brain, causing migraines.
According to Dr. Shivananda Pai, Consultant Neurology, migraines are more than a neurological disorder. "Migraines represent a complex interplay of genetic, environmental, and hormonal factors. In women, hormonal fluctuations are a critical trigger that amplifies sensitivity to pain," he explains. Hormonal headaches are particularly challenging because they are influenced by multiple life stages, from puberty to post-menopause. Common causes include:
Estrogen, often called the "hormone of femininity", does more than regulate reproductive functions. It is a powerful influencer of brain health. Estrogen modulates the activity of neurotransmitters like serotonin, which regulates mood and pain perception, and dopamine, associated with reward and pleasure.
During stages of hormonal stability, like in pregnancy's latter months, women may have fewer migraines because of the steady elevation of estrogen. However, a sudden downfall in estrogen destabilizes these chemicals in the brain, sending a heightened sensitivity for migraine triggers.
The most common form of hormonal migraines is menstrual migraines, which occur in response to the steep decline in estrogen levels just before menstruation. These are typically more intense and less responsive to standard treatment. The timing of these migraines provides clear evidence of the role hormones play in neurological health.
Pregnancy is a rollercoaster of hormones. Although many women experience relief from migraines as a result of the constantly elevated levels of estrogen, some women, particularly in the first trimester, worsen. This individual variability is a characteristic of hormonal migraine triggers.
Hormonal treatments, such as oral contraceptives and HRT, have had mixed reviews regarding their use in managing migraine. Some women fare better with the stabilization the treatment provides, whereas others suffer worsening symptoms. This will depend on the nature and dose of the hormones used.
For most women, menopause brings relief from their migraines. The decline in frequency and severity often accompanies stability in hormone levels. Even so, the susceptibility remains with some towards other forms of triggers including stress and sleep deprivation, not to forget diet-related factors and continues the saga of migraines well after the menopausal stages.
The relationship of hormones to neurological health goes beyond migraines. Hormonal changes have profound effects on a woman's brain in general.
Mood Disorders: Estrogen helps stabilize mood by regulating serotonin. Its decline at menopause increases the risk of mood swings and depression.
Neurodegenerative Diseases: Estrogen is neuroprotective, stimulating the growth and repair of brain cells. Its absence in post-menopausal women has been associated with an increased risk of Alzheimer's disease and cognitive decline.
Multiple Sclerosis (MS): Hormonal cycles may affect the course of MS, a disease that occurs more frequently in women than in men. Estrogen's anti-inflammatory effects provide transient protection during pregnancy, reducing relapse rates in women with MS.
"The intricate interplay between hormones and neurological health underscores the need for gender-specific treatment approaches," says Dr. Pai.
While hormonal changes are inevitable, several strategies can help manage migraines effectively:
Understanding your menstrual cycle can help identify patterns and predict when migraines might occur. This knowledge allows for preventive measures, such as scheduling medications or adjusting lifestyle habits.
Working with a neurologist or gynecologist can help develop a personalized treatment plan. Options might include hormonal therapies, triptans, or preventive medications tailored to your specific needs.
A well-balanced diet, regular exercise, and stress management are all integral parts of managing migraines. For instance, magnesium-rich foods and hydration can help reduce the frequency and severity of attacks.
For people with severe or frequent migraines, preventive medications, such as beta-blockers or CGRP inhibitors, may be prescribed. These medications stabilize brain activity and therefore reduce the chances of migraine during hormonal fluctuations.
Techniques like yoga, meditation, and biofeedback can enhance wellness and reduce the debilitating effects of stress-one of the most common migraine triggers.
Research that was once in its embryonic stage continues to shed more light on the role of hormones in migraines and other neurological conditions. Further breakthroughs in genetic testing might enable doctors to predict, at least in a way, how an individual would react to hormonal therapies. The importance of gender-specific approaches is gradually being realized, which involves differentiating between the plight of women with migraines from others.
As Dr. Pai puts it, "Empowering women with knowledge about the hormonal underpinnings of migraines can lead to better, more personalized care. With the right strategies, migraines can be effectively managed, allowing women to lead fuller, healthier lives.
Migraines are not headaches; they are a complex neurological condition that deeply impacts the lives of millions of women. Understanding the role of hormones in triggering and exacerbating migraines is a vital step toward better management and relief.
Awareness, proactive care, and advances in medical research can help women regain their lives from the grip of hormonal migraines. Whether tracking cycles, adopting healthier habits, or seeking tailored medical care, every step taken toward understanding and managing migraines is a step toward empowerment.
Dr Shivananda Pai is a Consultant Neurology at KMC Hospital Dr B R Ambedkar Circle in Mangalore, India.
Brandes JL. The Influence of Estrogen on Migraine: A Systematic Review. JAMA. 2006;295(15):1824–1830. doi:10.1001/jama.295.15.1824
Sacco S, Ricci S, Degan D, Carolei A. Migraine in women: the role of hormones and their impact on vascular diseases. J Headache Pain. 2012 Apr;13(3):177-89. doi: 10.1007/s10194-012-0424-y. Epub 2012 Feb 26. PMID: 22367631; PMCID: PMC3311830.
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From ground cinnamon to breakfast burritos, popcorn, and even pet food, food recalls in the U.S. seem to be appearing more often. Does this mean our food supply is becoming less safe? According to a report by compliance firm Sedgwick, the FDA and U.S. Department of Agriculture oversaw 294 food recalls in the first half of 2025. In the same period in 2024, the FDA had ordered the destruction of nearly 85 million units. USDA recalls impacted nearly 1.5 million pounds of food, almost three times more than last year.
Is this surge a sign that food production is failing, or does it reflect improvements in traceability? Perhaps the increase is due to better public access to information, allowing more recalls to be noticed. Or is U.S. food simply more contaminated than before?
The growing number of recalls has left shoppers worried about the safety of groceries. Experts, however, suggest that the increase doesn’t necessarily indicate declining food quality. Instead, it largely reflects advances in detecting contamination earlier and more efficiently.
As Lena Bakovic, MS, RDN, CNSC, from Live It Up explains, “The increase in the number of food recalls that we are seeing is likely largely due in part due to improvements in detection technologies, as well as generally stricter food safety testing requirements. Combined, these advancements help to provide earlier and more effective detection of potential contamination issues.”
Rather than showing a drop in quality, these recalls demonstrate that the system is working to protect public health. Improved testing and monitoring allow potential hazards to be identified and removed from shelves before reaching consumers.
In recent weeks, a number of U.S. food recalls have caught public attention. Over six million eggs from Black Sheep Egg Company were recalled due to possible salmonella contamination, impacting multiple states. Hormel Foods pulled nearly five million pounds of ready-to-eat chicken after metal fragments were discovered in food-service shipments. About 245,000 pounds of pre-cooked pasta, linked to a deadly listeria outbreak, were also recalled, causing several illnesses and deaths.
Frozen shrimp from various brands were removed over potential exposure to cesium-137, a radioactive isotope associated with cancer risk. More than two million pounds of Golden Island pork jerky were recalled after metal contamination was traced to a damaged conveyor belt. Additionally, ready-to-eat meals from meal-kit services like HelloFresh, Blue Apron, and Marley Spoon were pulled due to possible listeria contamination, which poses heightened risk to pregnant individuals, older adults, and immunocompromised people. Consumers are advised to discard or return affected products and consult healthcare professionals if needed.
Not all foods carry the same risk of contamination. Fresh produce, for example, is vulnerable because of its exposure during growth, harvesting, and transport. Packaged “ready-to-eat” meals can also be riskier because they bypass home cooking, a step that often eliminates harmful bacteria.
As Lena notes, “Some types of food are in fact more susceptible to contamination. Raw fruits and vegetables are examples of foods particularly in danger from microbial contamination due to their fresh condition, as well as exposure to potentially hazardous environmental influences. Additionally, food products which are commercially labelled and sold as ‘ready to eat’ can become more dangerous because they skip the at-home cooking process, which would likely eliminate any harmful pathogens in the first place.”
The health effects of eating recalled food depend on the contaminant. Bacteria like salmonella or E. coli can cause nausea, vomiting, and diarrhea, while chemical or allergen contamination may trigger allergic reactions or other toxic effects that aren’t immediately apparent.
“The health consequences can really vary depending on the root cause of the contamination,” Lena explains. “Bacterial pathogens like salmonella or E. coli can produce foodborne illnesses inducing gastrointestinal symptoms such as nausea, vomiting, and diarrhea. If a contaminant is a chemical or an allergen, allergy symptoms or other, potentially unknown, toxic effects are a possibility.”
Understanding recall classifications and keeping up with alerts can help protect your family from potentially harmful products.
In the U.S., food recalls are classified into three levels:
Class I: The most serious category, used when a product poses a significant health risk and could cause severe illness or even death. Examples include foods contaminated with bacteria like Salmonella or items with undeclared allergens.
Class II: Applies to products that may cause temporary or reversible health issues. For instance, yeast or mold contamination falls under this category.
Class III: The least serious, covering minor issues that are unlikely to harm but still break regulations, such as mislabeling—like placing a watermelon-flavored item in an apple package—without allergen concerns.
To stay updated, you can sign up for notifications on the FDA website or check Recalls.gov regularly. Be aware that alerts may include non-food products, so some filtering may be needed.
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In India, Pantop 40 has become almost a staple in many households, often consumed daily as casually as a multivitamin, particularly by those over 40. People frequently turn to it to manage acidity, often without considering the possible long-term consequences. What seems like a simple fix, however, can quietly lead to serious health issues. Recently, Dr. Shagun Agarwal, MBBS, M.S., FNB Joint Replacement, shared an advisory on Instagram highlighting the importance of limiting Pantop 40 use.
Pantoprazole is a medication designed to treat conditions caused by excessive stomach acid. It is commonly prescribed for erosive esophagitis or heartburn linked to gastroesophageal reflux disease (GERD), where stomach acid flows back into the esophagus. It can also be used for Zollinger-Ellison syndrome, a rare condition in which the stomach produces too much acid.
As a proton pump inhibitor (PPI), Pantoprazole works by lowering the amount of acid produced in the stomach. It is available only with a doctor’s prescription and comes in forms such as packets, delayed-release tablets, or powder for suspension.
Many people in India rely on Pantop 40 regularly, often treating it as completely harmless. After the age of 40–50, taking it has almost become a routine, without fully appreciating the potential health risks.
Dr. Agarwal explains that using Pantoprazole for long periods can cause serious complications. It may lead to deficiencies in vitamin B12 and magnesium, weaken bones and increase the risk of fractures, inflame the kidneys, trigger digestive problems like IBS, and most concerningly, cause rebound acidity, where acid reflux becomes worse once the medication is stopped.
It is crucial to remember that Pantoprazole is only a temporary fix. While it reduces stomach acid, it does not address the root causes of acidity or other digestive issues. Relying solely on the drug may bring short-term relief, but it cannot replace the benefits of healthy lifestyle adjustments.
Dosage varies depending on the patient and condition. Follow your doctor’s instructions carefully. The following information reflects general guidelines:
Dr. Agarwal emphasizes that many people rely on Pantop 40 to avoid changing their habits. Small, consistent lifestyle adjustments can have a significant impact on acidity. Eating smaller meals, avoiding trigger foods like coffee, fried, or spicy items, having dinner 2–3 hours before bedtime, and losing 5–10% of body weight can reduce acidity by nearly half, often without the need for long-term medication.
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In recent weeks, India’s air quality has taken a steep downturn, with “severe” pollution levels reported in cities such as Delhi, Gurugram, and others. Celebrity nutritionist and holistic wellness expert Luke Coutinho has issued a strong warning about the worsening air, calling it a public health crisis that is already affecting millions.
In a recent Instagram post, Luke admitted he is also struggling to cope with the toxic air—a feeling shared by many of his patients. “Dear citizens, this is more than a health issue; it’s a matter of social justice. Delhi’s air is a serious public health emergency, and parts of Mumbai are in poor to hazardous condition. This is a biological threat,” Luke stated in his post.
Luke explains that the primary culprit is PM2.5, which are tiny particles can enter the bloodstream, bypassing the body’s natural defenses and causing inflammation. “This isn’t just about coughing. Long-term exposure increases the risk of heart disease, stroke, cancer, chronic lung disease, and even lung and brain damage in children,” he adds.
The good news is that research shows reducing exposure, improving nutrition, and training the lungs can lower inflammation by 20 to 40 percent, according to Luke. He also shares a guide to help families start protecting their lung health.
To cut down exposure, the first step is to treat indoor spaces as your new outdoor environment. Avoid going out between 10 a.m. and 4 p.m., and check air quality indices like AQLin or SAFAR, especially keeping children indoors if the AQI is above 150. When stepping outside, wear a properly fitted N95 or KN95 mask to ensure 80–95 percent protection, as surgical masks are insufficient.
Indoors, treat air purifiers like essential medical devices. A HEPA purifier in the bedroom can reduce particulate matter by 50 to 70 percent, and it is important to replace filters regularly. Avoid incense, candles, and fireworks, and use a damp mop rather than sweeping to minimize dust.
Lastly, quit smoking entirely, as it compounds the lung damage caused by pollution. Reducing exposure is the single most effective step and can slow lung decline by up to 30 percent.
A diet rich in anti-inflammatory, high-antioxidant foods can reduce pollution-related damage by as much as 35 percent. Include two cups of leafy greens like spinach, kale, and Swiss chard daily, which can be added to smoothies or soups. Add one to two cups of steamed cruciferous vegetables such as broccoli, cabbage, and cauliflower; quick steaming is better than boiling.
Consume two to three servings of antioxidant-rich fruits like guava, apples, and strawberries, with guava highlighted as an excellent source of vitamin C. Include one cup of carotenoids or lycopene from foods like carrots and tomatoes, noting that cooking tomatoes with a little oil improves absorption.
Get omega-3 fats from two to three servings of fatty fish per week or one handful of nuts and seeds daily, such as salmon, walnuts, or flaxseeds, which support heart health. Limit processed sugars, refined carbs, excess salt, and deep-fried foods to under 10 percent of total calories, as they promote inflammation. Stay well-hydrated with two to three liters of water daily to thin mucus and support the lungs’ natural cleansing processes.
Luke suggests remembering key supplements with the code CODE-Z: C for vitamin C, O for omega-3s, D for vitamin D, E for vitamin E, and Z for zinc. Vitamin C (500–1000 mg/day) from guava and strawberries acts as a powerful antioxidant for the lungs. Omega-3s (EPA/DHA) from salmon or walnuts (1000–2000 mg/day) help reduce inflammation from pollution.
Vitamin D (2000–4000 IU/day), found in cod liver oil and fortified milk, supports immunity and lowers infection risk. Vitamin E (200–400 IU/day) from sunflower seeds and almonds protects lung cells with fat-soluble antioxidants. Supplements are helpful during acute pollution exposure, but food should remain the primary source of nutrients. It is important to take supplements under professional guidance, cycle them every 2.5 months, and consult a doctor before starting any new regimen, especially for children.
To strengthen the lungs, practice targeted breathing exercises and maintain humidified air. Pursed-lip breathing involves inhaling for two to four seconds and exhaling for four to six seconds through pursed lips; practicing this for five minutes twice daily can ease breathlessness.
Diaphragmatic breathing strengthens the main breathing muscle, allowing for deeper and more efficient breaths. Additionally, five minutes of steam or humidified air daily keeps airways moist and helps clear mucus, supporting overall respiratory resilience.
But remember, always keep your doctor informed before starting any new supplements or changing your diet, especially for children or if you have an existing health condition. Don’t ignore early warning signs, like persistent cough, fatigue, or shortness of breath, which should be checked promptly. Above all, focus on minimizing your exposure to polluted air first.
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