For those who have not experienced a migraine, perhaps it would seem just another headache. But for someone like me who has suffered through migraines that will last over a week even with medication, I can definitely tell you that it's much more. The ache is not confined to the head; it's the whole experience. Nausea, sensitivity to light, and throbs so bad it makes simple tasks unbearable. It also comes with an emotional burden—the loneliness and frustration are pretty unbearable. Through the years, realizing how hormones are also implicated in triggering and exacerbating my migraines has helped change the game in my dealing with these episodes.

What are Hormonal Migraines?

Hormonal migraines are caused by fluctuations in estrogen and progesterone, the two main female hormones. These hormones are essential for the reproductive system, regulating menstrual cycles and pregnancy. They also have an effect on brain chemicals, such as serotonin and dopamine, which affect mood and pain perception. When hormone levels fluctuate, such as during menstruation, pregnancy, or menopause, they can destabilize the pathways in the brain, causing migraines.

According to Dr. Shivananda Pai, Consultant Neurology, migraines are more than a neurological disorder. "Migraines represent a complex interplay of genetic, environmental, and hormonal factors. In women, hormonal fluctuations are a critical trigger that amplifies sensitivity to pain," he explains. Hormonal headaches are particularly challenging because they are influenced by multiple life stages, from puberty to post-menopause. Common causes include:

• Menstrual periods: Estrogen levels significantly drop just before menstruation often triggers a migraine.
• Pregnancy: Hormones can act to relieve symptoms or aggravate them during different times of pregnancy.
• Menopause: The hormonal fluctuation during menopause can intensify a migraine, while some women tend to find relief.
• Hormonal therapies: Birth control and HRT tend to level off hormone balances in some individuals but will exacerbate a migraine in others.

Complex Role of Hormones in Women’s Neurological Health

Estrogen and Neurological Health

Estrogen, often called the "hormone of femininity", does more than regulate reproductive functions. It is a powerful influencer of brain health. Estrogen modulates the activity of neurotransmitters like serotonin, which regulates mood and pain perception, and dopamine, associated with reward and pleasure.

During stages of hormonal stability, like in pregnancy's latter months, women may have fewer migraines because of the steady elevation of estrogen. However, a sudden downfall in estrogen destabilizes these chemicals in the brain, sending a heightened sensitivity for migraine triggers.

Menstrual Migraines

The most common form of hormonal migraines is menstrual migraines, which occur in response to the steep decline in estrogen levels just before menstruation. These are typically more intense and less responsive to standard treatment. The timing of these migraines provides clear evidence of the role hormones play in neurological health.

Pregnancy and Hormonal Shifts

Pregnancy is a rollercoaster of hormones. Although many women experience relief from migraines as a result of the constantly elevated levels of estrogen, some women, particularly in the first trimester, worsen. This individual variability is a characteristic of hormonal migraine triggers.

Hormonal Therapies and Management of Migraine

Hormonal treatments, such as oral contraceptives and HRT, have had mixed reviews regarding their use in managing migraine. Some women fare better with the stabilization the treatment provides, whereas others suffer worsening symptoms. This will depend on the nature and dose of the hormones used.

Post-Menopause: Migraine Remission or Continued Struggles?

For most women, menopause brings relief from their migraines. The decline in frequency and severity often accompanies stability in hormone levels. Even so, the susceptibility remains with some towards other forms of triggers including stress and sleep deprivation, not to forget diet-related factors and continues the saga of migraines well after the menopausal stages.

Effect on Neurological Health Due to Hormonal Changes

The relationship of hormones to neurological health goes beyond migraines. Hormonal changes have profound effects on a woman's brain in general.

Mood Disorders: Estrogen helps stabilize mood by regulating serotonin. Its decline at menopause increases the risk of mood swings and depression.

Neurodegenerative Diseases: Estrogen is neuroprotective, stimulating the growth and repair of brain cells. Its absence in post-menopausal women has been associated with an increased risk of Alzheimer's disease and cognitive decline.

Multiple Sclerosis (MS): Hormonal cycles may affect the course of MS, a disease that occurs more frequently in women than in men. Estrogen's anti-inflammatory effects provide transient protection during pregnancy, reducing relapse rates in women with MS.

"The intricate interplay between hormones and neurological health underscores the need for gender-specific treatment approaches," says Dr. Pai.

Managing Hormonal Migraines: Practical Strategies

While hormonal changes are inevitable, several strategies can help manage migraines effectively:

1. Tracking Your Cycle

Understanding your menstrual cycle can help identify patterns and predict when migraines might occur. This knowledge allows for preventive measures, such as scheduling medications or adjusting lifestyle habits.

2. Consulting Specialists

Working with a neurologist or gynecologist can help develop a personalized treatment plan. Options might include hormonal therapies, triptans, or preventive medications tailored to your specific needs.

3. Adopting a Healthy Lifestyle

A well-balanced diet, regular exercise, and stress management are all integral parts of managing migraines. For instance, magnesium-rich foods and hydration can help reduce the frequency and severity of attacks.

4. Exploring Preventive Therapies

For people with severe or frequent migraines, preventive medications, such as beta-blockers or CGRP inhibitors, may be prescribed. These medications stabilize brain activity and therefore reduce the chances of migraine during hormonal fluctuations.

5. Mind-Body Techniques

Techniques like yoga, meditation, and biofeedback can enhance wellness and reduce the debilitating effects of stress-one of the most common migraine triggers.

Research that was once in its embryonic stage continues to shed more light on the role of hormones in migraines and other neurological conditions. Further breakthroughs in genetic testing might enable doctors to predict, at least in a way, how an individual would react to hormonal therapies. The importance of gender-specific approaches is gradually being realized, which involves differentiating between the plight of women with migraines from others.

As Dr. Pai puts it, "Empowering women with knowledge about the hormonal underpinnings of migraines can lead to better, more personalized care. With the right strategies, migraines can be effectively managed, allowing women to lead fuller, healthier lives.

Migraines are not headaches; they are a complex neurological condition that deeply impacts the lives of millions of women. Understanding the role of hormones in triggering and exacerbating migraines is a vital step toward better management and relief.

Awareness, proactive care, and advances in medical research can help women regain their lives from the grip of hormonal migraines. Whether tracking cycles, adopting healthier habits, or seeking tailored medical care, every step taken toward understanding and managing migraines is a step toward empowerment.

Dr Shivananda Pai is a Consultant Neurology at KMC Hospital Dr B R Ambedkar Circle in Mangalore, India.

Brandes JL. The Influence of Estrogen on Migraine: A Systematic Review. JAMA. 2006;295(15):1824–1830. doi:10.1001/jama.295.15.1824

Sacco S, Ricci S, Degan D, Carolei A. Migraine in women: the role of hormones and their impact on vascular diseases. J Headache Pain. 2012 Apr;13(3):177-89. doi: 10.1007/s10194-012-0424-y. Epub 2012 Feb 26. PMID: 22367631; PMCID: PMC3311830.

The NHS has issued an alert for anyone taking a widely used heart medication. People are being advised to watch for serious warning signs, including yellowing of the skin or “nosebleeds lasting more than 10 minutes.”

What Is Propranolol?

Propranolol is a beta blocker that slows the heart rate and relaxes blood vessels, helping lower blood pressure and reduce the heart’s oxygen demand. It is also prescribed to ease symptoms of anxiety, such as trembling or excessive sweating, and can help prevent migraines. The medication is prescription-only but is commonly prescribed throughout the UK.

According to the Mirror, the British Heart Foundation reports that more than 50 million beta blocker prescriptions are issued in the UK each year, including for propranolol. Patients usually take it once a day, in either a standard or slow-release form.

While propranolol is generally safe, it does carry possible side effects. The NHS advises contacting 111 immediately if serious symptoms affecting the blood or kidneys appear.

The NHS notes: “Like all medicines, propranolol can cause side effects in some people, but many experience none or only minor effects. Side effects often ease as your body adjusts to the medication.”

Propranolol Side Effects

Common side effects include headaches, fatigue, weakness, cold fingers or toes, nausea, and stomach discomfort. While most people over 12 can safely take propranolol, the NHS recommends consulting a doctor first if you have a history of low blood pressure, heart failure, depression, or diabetes.

More serious reactions can occur, including yellowing of the eyes or skin, pale stools, or dark urine. The NHS also warns of nosebleeds lasting longer than 10 minutes, unexplained bruising, or increased tendency to bruise easily.

Anyone experiencing these warning signs should contact a doctor or call 111 immediately. The NHS also cautions against stopping propranolol abruptly without medical guidance, as this could trigger severe heart problems, including chest pain or even a heart attack.

Who Should Be Extra Cautious With Propranolol

While propranolol is widely prescribed and generally safe for most adults, certain people need to monitor themselves more closely or consult their doctor before use. Those with low blood pressure, heart failure, slow heart rates, diabetes, respiratory conditions like asthma, or a history of depression may face higher risks of side effects. Pregnant or breastfeeding women should also speak to a healthcare professional before taking the medication.

The NHS emphasizes that even minor symptoms—like unusual fatigue, dizziness, or cold hands and feet—should not be ignored, especially if they worsen over time. Monitoring for these effects early can prevent more serious complications.

Disclaimer: This article is for informational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you experience any side effects or unusual symptoms while taking propranolol or any other prescription medicine, seek medical attention immediately.

A California man died last weekend after eating so-called death cap mushrooms, marking the third fatality linked to the toxic fungi in the state since November.

Health officials say California is seeing an unusually high number of mushroom poisonings this season. Between November 18 and January 4, at least 35 cases were reported statewide. In a typical year, the number is usually fewer than five.

“This year’s figures are far beyond what we normally see,” said Sheri Cardo, a communications specialist with the California Department of Public Health.

California Resident Dies After Eating Death Cap Mushrooms

At least three people have now lost their lives in California due to death cap mushroom poisoning since November. Media reports indicate a sharp rise in cases tied to foraged wild mushrooms, with more than 35 poisonings recorded over the past three months.

“The numbers we’re dealing with this year are comparatively off the charts,” Cardo told NBC News.

The most recent death occurred in Sonoma County and was the first fatal wild mushroom poisoning reported there this season, according to county health officials.

Dr. Michael Stacey, interim health officer for Sonoma County, urged residents to avoid eating wild mushrooms unless they are purchased from reliable grocery stores or licensed sellers. He warned that death cap mushrooms can look strikingly similar to safe, edible varieties.

What Is Death Cap Mushroom Poisoning?

Death cap mushrooms, scientifically known as Amanita phalloides, are among the most poisonous mushrooms in the world. They commonly grow beneath oak trees and can be found in parks, gardens, and wooded areas.

Experts say these mushrooms are often mistaken for edible types because of their appearance. Typical features include:

• A smooth cap that may appear whitish, pale yellow, light brown, or green
• White gills underneath the cap
• A white spore print
• A cup-like structure called a volva at the base of the stem
• A ring, known as an annulus, around the stem

Death Cap Mushroom Symptoms

Symptoms usually begin between six and 24 hours after ingestion. Early signs often include stomach pain, nausea, vomiting, and diarrhoea.

In many cases, symptoms ease or disappear after one or two days, which can create a false sense of recovery. By that point, however, the toxins may have already caused severe damage to the liver.

According to experts, the poison responsible, known as amatoxin, can seriously harm the liver, kidneys, and digestive system. Without prompt treatment, the damage can be fatal.

U.S. Poison Centers receive an average of about 52 calls each year related to amatoxin exposure, said Hallen-Adams, though not every case is officially reported.

Is the Risk Easing?

The danger may now be starting to decline in parts of California. Mike McCurdy, president of the Mycological Society of San Francisco, said he has noticed far fewer death cap mushrooms during recent foraging trips.

Earlier this winter, McCurdy said he spotted hundreds of death caps during a two- to three-hour walk in Sonoma County. On a recent outing near Lafayette, California, he found just one. “I think we’re getting close to the end,” he said.

Nearly four years ago, Teresa Sanchez was in Mexico for a medical procedure when her right eye began to feel unusually dry and irritated. At first, it seemed minor. She assumed her contact lens might be torn or that the switch from daily lenses to monthly ones was causing dryness. She even wondered if her body was fighting off an infection, as per CNN.

What she did not realize at the time was that a microscopic organism was slowly attacking her cornea. Over the next three months, the parasite caused irreversible damage to her vision and triggered searing pain that spread across her head.

“I couldn’t even keep the blinds open in my room,” said Sanchez, now 33 and living in Las Vegas. “Light would cause unbearable pain. That’s when I knew something was seriously wrong.”

By then, she had already seen multiple optometrists and had been misdiagnosed. Frustrated and desperate for answers, Sanchez began researching her symptoms on her own.

What Is Acanthamoeba Keratitis?

Online searches led Sanchez to a condition she had never heard of: acanthamoeba keratitis. An eye specialist later confirmed it. Keratitis refers to inflammation of the cornea, the clear, dome-shaped layer at the front of the eye that plays a central role in focusing vision. Acanthamoeba is a microscopic, single-celled organism that cannot be seen without a microscope.

According to Dr. Jacob Lorenzo-Morales, a professor of parasitology at the University of La Laguna in Spain, acanthamoeba is commonly found in soil and water. It does not require a host to survive, which makes it especially resilient.

Once the organism comes into contact with the eye, it can attach itself to the cornea. Dr. Paul Barney, an optometric physician and director at the Pacific Cataract and Laser Institute in Alaska, explained that even tiny breaks in the corneal surface can allow the parasite to burrow deeper into the eye.

Why Contact Lens Wearers Face Higher Risk?

Acanthamoeba keratitis is considered rare. Based on data from 20 countries, including the UK, India, the US, Canada and Brazil, there are more than 23,000 cases worldwide each year. Yet a striking pattern stands out. Between 85% and 95% of people who develop the infection wear contact lenses.

Contact lenses can cause microscopic abrasions on the cornea, creating an entry point for the parasite. The organism can also cling to the lens itself or become trapped between the lens and the eye, making it easier to penetrate the corneal tissue.

“If it’s not diagnosed early and treated aggressively, the outcome can be devastating,” Barney said. “The parasite feeds on the cornea, triggering inflammation and tissue damage that can lead to permanent vision loss.”

In some cases, vision can be partially restored with treatment. Others require a corneal transplant.

A Parasite Built To Survive

Treating acanthamoeba keratitis is especially difficult because the organism has strong defense mechanisms. It can sense threats and respond by forming a cyst, allowing it to lie dormant for months or even years.

This resilience means treatment often stretches over long periods and involves intense discomfort. Because the eye is extremely sensitive, patients must work closely with specialists and strictly follow treatment instructions.

Why The Condition Is Often Missed?

Early diagnosis is one of the biggest challenges Because acanthamoeba keratitis is uncommon, many optometrists may not recognize it right away. As a result, many contact lens users only learn about the condition after they develop it or come across viral videos discussing it online.

Many patients have expressed surprise that they were never clearly warned about the risks of wearing contacts while showering or swimming.

The Contact Lens Society of America emphasized that contact lenses are medical devices and require strict hygiene. This includes avoiding water exposure during swimming, showering or sleeping. The organization also stressed the importance of patients asking questions and carefully reviewing care instructions.

Acanthamoeba Keratitis: Symptoms That Mimic Other Eye Infections

In addition to severe pain and light sensitivity, acanthamoeba keratitis can cause redness, blurred vision, dryness, excessive tearing and the sensation that something is stuck in the eye.

Because these symptoms overlap with other conditions, misdiagnosis is common. Barney said the infection is frequently mistaken for herpes simplex keratitis, a major cause of infection-related blindness. In its earliest stages, it can even resemble pink eye.

That was the case for Sanchez. Her first optometrist diagnosed pink eye. The prescribed drops blurred her vision. A second optometrist suspected a bacterial infection, and while antibiotic drops offered brief relief, she soon lost vision in the affected eye.

Acanthamoeba Keratitis: How To Reduce Your Risk?

Experts stress that contact lens hygiene is critical. Always clean and store lenses using approved contact lens solution, never water. The solution in your lens case should be replaced daily. Wash and dry your hands thoroughly before handling lenses.

Sleeping in contact lenses should be avoided, as it increases dryness, irritation and the risk of corneal damage. Daily disposable lenses may lower infection risk compared to monthly lenses.

For water-based activities, glasses or prescription goggles are safer options. Some people may also consider vision correction surgery after discussing risks and suitability with a doctor.