When was the last time you measured your waistline? If you assume that BMI is the only number to focus on when it comes to your health, think twice. New research has revealed a shocking revelation—your waist circumference might be a far better predictor of men's cancer risk than BMI.

The study finds that for each 4-inch increase in waist size, a man's risk of cancer increases by a staggering 25%. Meanwhile, BMI, commonly regarded as the gold standard for assessing obesity, raises cancer risk by only 19% for the same weight gain. So, if you've been dismissing that pesky belly fat, it's time to take notice.

But why is your waistline so important? The reason is visceral fat—the hidden, deep fat that accumulates around your organs. Unlike other body fat, visceral fat is a stealthy troublemaker, causing inflammation, insulin resistance, and abnormal blood fat levels—all of which combine to create a cancer-perfect storm.

Obesity has been associated with an increased risk of numerous health conditions, including cancer, for decades. The research, though, indicates that a specific measure of the body—waist circumference—may be an even more reliable forecaster of cancer risk in men than the more frequently employed Body Mass Index (BMI). This finding emphasizes the need to pay particular attention to the distribution of fat and not merely to the weight of the body.

BMI has been the go-to measure for years for gauging health risks related to obesity. New research, though, that appears in The Journal of the National Cancer Institute indicates that waist measurement is a better predictor of cancer risk in men. According to the research, four more inches (10 cm) around the waist will add 25% to a man's cancer risk. Conversely, a 3.7 kg/m² rise in BMI (from a BMI of 24 to 27.7) increased cancer risk by only 19%.

Why is waist circumference a better predictor, then? Unlike BMI, which measures weight relative to height, waist circumference actually measures abdominal fat—specifically, visceral fat. This type of fat encircles internal organs and is also linked to higher levels of inflammation, insulin resistance, and abnormal blood lipids, all of which are factors in cancer growth. BMI, however, does not measure fat distribution, so two individuals with the same BMI can have very different levels of health risk depending on where fat is deposited on their bodies.

Why Men Are at Higher Risk?

Interestingly, the research identified a significant difference between men and women when it came to waist circumference and cancer risk. Although waist circumference and BMI were linked with obesity-related cancers in women, the relationship was weaker than for men. An increase of 12 cm (4.7 inches) in waist size or a 4.3 rise in BMI (from 24 to 28.3) raised the cancer risk in women by just 13%—a much lower percentage than for men.

Experts credit this difference to the way that fat is stored in the body. Men are more likely to carry fat around the abdomen, especially as visceral fat, which is more metabolically active and associated with cancer-producing biological alterations. Women, by contrast, store fat in peripheral sites such as the hips and thighs, where it is less likely to drive systemic inflammation and metabolic disturbances.

A possible reason is that men tend to depot fat more in the visceral regions, whereas women tend to carry more subcutaneous and peripheral fat," wrote the researchers. "This may render waist circumference a more robust risk factor for cancer in men and account for why waist circumference provides additional risk information beyond BMI in men but not women."

Cancer Types Most Linked to Abdominal Fat

The research used the International Agency for Research on Cancer (IARC) data to define obesity-related cancers. These cancers are esophageal (adenocarcinoma), gastric (cardia), colorectal, rectal, liver, gallbladder, pancreatic, renal, and thyroid cancers, and multiple myeloma and meningioma. In men, abdominal obesity is especially significant in raising the risk of these cancers through high levels of insulin and markers of inflammation.

For women, the research proposes that both waist circumference and hip circumference may give a more accurate estimate of visceral fat and cancer risk. "Adding hip circumference to risk models could strengthen the link between waist circumference and cancer, especially in women," researchers observed.

What This Means for Men's Health and Cancer Prevention?

With these results, doctors advise men to be more mindful of their waistline than only their BMI. Waist size is an easy method to gauge health risk, and its maintenance through lifestyle changes might be the key to cancer prevention.

How To Reduce Cancer Risk In Men?

Track Your Waist Size: Regularly measure your waist circumference and try to keep it in a healthy range (below 40 inches for men, according to medical advice).

Eat a Balanced Diet: A diet containing high fiber, lean protein, and healthy fats can assist in limiting visceral fat gain.

Exercise Consistently: Regular exercise with a combination of aerobic and strength training will help maintain a healthy waistline.

Control Stress and Sleep: Persistent stress and inadequate sleep tend to cause weight gain, especially in the midsection of the body.

Regular Health Screenings: Early identification of cancer risk factors through regular screening can greatly enhance long-term health status.

Dianna Cowern, the science communicator with more than two million YouTube subscribers, was at the peak of her career in 2022. Featuring millions of views, her YouTube channel ‘Physics Girl’, featured her travelling across the world filming science videos. She had also recently married her longtime partner, Kyle Kitzmiller.

Then, after contracting COVID-19 during her honeymoon in Scotland, her life took a turn in ways she could not have anticipated.

What initially started off as a mild infection was followed by a sharp decline in her physical and mental health. A hike she had planned with her husband became an impossible task for her. After that rest no longer seemed to help her recover.

Cowern's experience highlights the disabling effects of Long COVID, a condition that researchers are still trying to understand.

She recalled the time when her symptoms escalated, “Brain fog like I'd never experienced before. I couldn't walk. I couldn't think. I had nausea and headaches,” she said. “And I never recovered from that crash.”

From An Active Life To Confined To Bed

Also read: Long COVID: Mouth And Lung Bacteria May Offer Clues

According to KPBS, Cowern's initial COVID-19 symptoms included a sore throat, cough and stuffy nose. After they subsided, she and Kitzmiller began a multiday hike they had planned for months. By the third day, she was struggling to recover even after resting and had to take a cab to the next location while her husband continued on foot.

The couple cut their honeymoon short and returned to San Diego. Her health continued to decline. She first lost the ability to run and hike, then struggled to work and walk. Eventually, she became unable to speak, read or use her phone.

Sensitivity to light and sound left her spending her days in a dark room, wearing dark glasses and noise-cancelling headphones to limit stimulation. Kitzmiller became her full-time caregiver.

He also recalled episodes in which her heart rate dropped into the 30s. He used a pulse monitor with an alarm and slept waiting for it to sound. “Every day I didn't know if she was just gonna die,” he said.

The couple sought medical help, but tests failed to provide clear answers. Kitzmiller described the response they had received from doctors. He said they said, “There's not a real disease here.”

Long COVID Is Part Of Post-Acute Infection Syndromes

Also read: Long COVID Symptoms Are Closer To A Stroke Or Parkinson's Disease Than Fatigue

Long COVID refers to symptoms that occur after a SARS-CoV-2 infection and cannot be explained by another diagnosis. Symptoms vary widely and may include fatigue, cognitive difficulties, breathlessness, sleep disturbances and problems with everyday activities.

Some people improve over time, while others experience prolonged illness that affects their ability to lead routine lives.

Long COVID is also part of a bigger group of conditions known as post-acute infection syndromes, in which people continue to experience symptoms after an infection has gone.

Researchers are examining possible explanations behind Long COVID, including prolonged immune dysfunction and other changes triggered by infection.

Treatments Improved Symptoms But Road To Recovery Was Far

With few established treatment alternatives available, Cowern explored options suggested by researchers, although they were not approved for Long COVID. She reported a significant improvement after trying some of them.

“I was able to start looking at my phone again and reading and listening to music, which was amazing,” she said. “And then everything improved.”

After three years, she eventually returned to making science videos. But her return has not meant a full recovery. Cowern says that she is functioning at around 30% to 40% of her previous capacity.

She and Kitzmiller are now using their platform to raise awareness about chronic illness. Kitzmiller has also joined an advisory committee for clinical trials investigating a treatment that helped her.

“There’s still a lot to learn,” Cowern said. “There's so little that's understood about this disease, but I will say that everyone that has it is desperate to live again.”

Air pollution, chemicals that interfere with hormonal health and stress due to climate may be contributing to South Asia’s growing burden of diabetes and heart disease. The Lancet study has highlighted the importance of considering other factors than diet and physical inactivity when addressing metabolic health.

A paper published in The Lancet Regional Health – Southeast Asia argues that the environmental conditions people face throughout their lives could play a key role in worsening cardiometabolic health.

The authors specifically point to a combination of exposures, from fine particulate matter in polluted air to chemicals in consumer products, that could influence how body regulates blood sugar, stores fat and maintains healthy blood vessels.

The paper, titled South Asia’s cardiometabolic burden: exposomal determinants of a health transition, was authored by Misra and Yashendra Sethi of the Department of Medicine at Subharti Medical College, Swami Vivekanand Subharti University, Meerut.

Effects Of Environmental Exposures On Metabolic Health

Also read: Delhi Air Pollution: Experts Explain Why You Feel Unusually Tired When AQI Rises

The authors use the term “exposome” to denote the range of environmental factors a person sees over their lifetime living in a particular city. These include air pollution, chemical contaminants, dietary patterns, sleep pattern and stress.

Fine particulate matter, or PM2.5, is the primary concern, according to the authors. These tiny airborne particles can seep deep into the lungs and cause inflammation that could worsen cardiovascular and respiratory illness.

The paper also highlights how prolonged exposure may contribute to metabolic dysfunction, including oxidative stress, insulin resistance and damage to the lining of blood vessels.

Chemical exposures are another area of concern. Bisphenols, phthalates and per- and polyfluoroalkyl substances (PFAS), found in various industrial and consumer applications, can interfere with hormone health. Depending on the level of exposure, these chemicals may have an effect on insulin sensitivity, appetite and fat cells in the body.

Other lifestyle will only fuel these risks. Irregular sleep, shift work and disrupted body clocks can interfere with metabolic health, while unhealthy diets featuring ultra-processed foods and stress may contribute to inflammation and other reasons that lead to chronic diseases.

The authors say that these overlapping exposures could help explain why conditions like type 2 diabetes, steatotic liver disease and cardiovascular disease are becoming alarming public health concerns in South Asia. However, the contribution of individual exposures and their combined effects requires further investigation.

South Asians Face Greater Risks Of Chronic Diseases

South Asians can develop type 2 diabetes and cardiovascular disease at younger ages and at lower body mass index levels than many Western populations. The paper places the region’s rapid economic and social transformation behind this vulnerability.

It means that generations that experienced undernutrition for centuries now live in environments influenced by urbanisation, better transport, changing diets and greater exposure to pollution. Biological tendencies towards energy storage may interact with these newer conditions, increasing metabolic risk.

Across the Asia-Pacific region, the burden of cardiometabolic disease, measured in life years after adjusting disability, rose between 1.7-fold and 3.7-fold from 1990 to 2023.

Also read: Rising AQI In Delhi-NCR: Doctors Warn Of Lung And Heart Risks As Pollution Builds

Approach For Prevention

The authors argue that advice on eating well, exercising and sleeping adequately remains important, but they cannot help when people have limited control over the air they breathe or the environmental quality.

The paper recommends monitoring environmental exposures, intervening early in life, strengthening food policies, and conducting long-term research to understand how exposures influence cardiometabolic outcomes.

The boom in GLP-1 weight loss drugs is not only affecting the obesity market but also reshaping the beauty industry. Changes in consumer behaviour among those who use GLP-1 drugs is evident as people may see differences in their appearance after drastic weight loss. This phenomenon has prompted global beauty companies to explore products for people experiencing changes in their appearance after losing weight.

French cosmetics giant L’Oréal is among the companies exploring this emerging market segment. Its CEO, Nicolas Hieronimus, said the increasing use of these medications was affecting beauty and skincare consumption, compelling the company to explore products that address concerns like sagging skin after extreme weight loss.

“The rise in their (GLP-1 drugs) use was having an impact on beauty consumption and skin care consumption in particular,” Hieronimus said during an investor call on October 22, after the company's third-quarter results came out.

The development mirrors an important shift in the beauty industry as weight loss medications like Ozempic, Wegovy and Zepbound become more widely used for weight management.

Amid the growing market for these drugs, companies are now seeing increased demand for treatments that help changes in facial volume, skin firmness and elasticity after weight loss.

However, the science behind ‘Ozempic face’ is far more complicated than the name suggests. Experts say these changes are generally associated with losing facial fat during weight loss, especially when it happens rapidly.

What is ‘Ozempic Face’?

‘Ozempic face’ is an informal term for facial changes that occur after rapid and substantial weight loss. It is marked by hollowing around the cheeks and temples and more noticeable wrinkles or sagging skin.

GLP-1 medicines, including semaglutide and tirzepatide, act on appetite regulation, helping people feel fuller for a long time and reducing their calorie intake. As a result, some people lose a substantial amount of weight over a short period.

Beauty Companies Respond to GLP-1 Boom

Apart from L’Oréal, Swiss skincare company Galderma and Brazilian cosmetics group Natura are also seeing similar demands from consumers experiencing changes in their facial skin after medicated weight loss.

L’Oréal has said that it is testing products on people using GLP-1 medications. Its SkinCeuticals range also has products intended to address concerns such as skin sagging, according to Hieronimus.

“We have products in SkinCeuticals that are made to work alongside GLP-1 drugs and address their side effects, such as skin sagging and other related issues. It is very integrated,” he said.

Galderma, in which L’Oréal holds a 20% stake, has assessed some of its existing aesthetic treatments for changes due to GLP-1 use. Its portfolio includes Sculptra, an injectable that stimulates collagen, and Restylane, a range of hyaluronic acid-based dermal fillers.

Anne-Cecile Chevrier, Galderma's global head of injectable aesthetics, described the concerns that experts are seeing among consumers. “Sagginess is a concern, loss of firmness is a concern, some hollowness can be of concern and dullness can be a concern,” she said.

Can Skincare Products Reverse ‘Ozempic Face’?

The expansion of this market does not necessarily mean that skincare products can reverse facial changes due to rapid weight loss.

The skin has several layers, and topical products act on the skin's surface. Facial fat loss happens when fat accumulated beneath the skin melts off. Skincare products cannot simply replace this process.

Dr Graeme Glass, a plastic and craniofacial surgeon and aesthetic director at British beauty brand LYMA, explained the limitations of topical treatments. “They can't reposition the deep fat pads of the face. There is a limit to what these things can do,” he said.

Moisturisers and other products may help improve hydration, texture and the appearance of fine lines. But these benefits should not be confused with correcting sagging skin.

Treatments like fillers and collagen injectables may address these concerns directly, but they involve different risks, costs and clinical considerations.

Avani Sinha, MD, and FACE endocrinologist and program director of the Northwell Health Division of Endocrinology, Diabetes and Metabolism fellowship told Women's Health Magazine that it is important to take care of nutrition and muscle-building to "fill up spaces where you are losing that skin laxity".

“We are what we eat, we are what we do,” she said, stating that protein intake is especially important on a GLP-1. She suggested aiming 0.8 to 1.8 grams per kilogram of body weight.

Sinha also recommended staying hydrated along with strength training to build muscle. “You build up that muscle, you're going to fill up those spaces where you're losing that skin laxity,” she said.