A carnivore diet is a restrictive diet that only includes meat, fish, and other animal products like dairy and eggs. More recently, it has been brought into the limelight by influencers and social media personalities. In fact, there is a whole community of "meatfluencer" who are sharing their meat-eating plans. One of them is Dr Paul Saladino MD, whose belief that there was no better way to prevent chronic diseases than a carnivore diet prompted him to write books and post videos regarding the same. He believed so much in this eating plan that he became a go-to person for many following the same plan, until recently, when he decided to quit.

Here Are Seven Reasons Why He Decided To Quit

Carnivore Diet Disrupted His Sleep

Switching to an all-meat diet isn't always straightforward, especially when it comes to digestion—a lesson Dr Saladino learned firsthand. He experienced sleep disturbances, likely due to the difficulty of digesting high-protein meals. Since protein takes longer to break down, it demands more energy from the body, which can interfere with rest.

According to Johns Hopkins Medicine, digestion slows by up to 50% during sleep. Additionally, many types of meat contain tyramine, a compound derived from the amino acid tyrosine. Increased tyramine intake can lead to health issues and also triggers the release of norepinephrine, a hormone that raises heart rate and blood pressure, making restful sleep harder to achieve.

He also experienced hypnagogic jerks—sudden muscle spasms that jolt the body awake. "I would fall asleep but then jerk myself awake like I was falling multiple times. It was stressful and traumatic, leading to poor sleep," he shared in his YouTube video.

Eating Only Meat May Have Triggered Heart Palpitations

Another concerning side effect Dr Saladino experienced was heart palpitations—episodes where his heart felt like it was racing or fluttering. While stress is a common cause, few would immediately link palpitations to meat consumption.

However, a sudden shift to an all-meat diet can lead to electrolyte imbalances. The elimination of carbohydrates lowers insulin levels, prompting the kidneys to excrete more sodium. This disrupts the balance of essential minerals like potassium and magnesium, which are crucial for heart function.

Muscle Cramps Became Persistent

Dr Saladino also suffered from frequent muscle cramps while following the carnivore diet. In a post on X, he emphasized the importance of maintaining adequate magnesium, calcium, and potassium levels to prevent cramping. He initially believed that animal-based foods provided sufficient minerals, but his ongoing cramps led him to reconsider.

"I started to think maybe long-term ketosis is not great for me,” he admitted on the *More Plates More Dates* podcast. “Probably not a great thing for most humans."

His Testosterone Levels Dropped Significantly

Dr Saladino also saw a decline in his testosterone levels after following the carnivore diet for over a year. "At the beginning of my carnivore experiment, my testosterone was about 800. After a year to a year and a half, it had dropped to around 500," he revealed.

The issue likely stems from excessive protein intake, which can elevate inflammation and disrupt hormone levels. A 2022 study published in Nutrition and Health found that consuming more than 35% of daily calories from protein can lead to various negative effects, including reduced testosterone.

He Had Chronically Low Insulin Levels

Because he largely eliminated carbohydrates—except for a small amount of fruit—Dr Saladino developed persistently low blood sugar. In his YouTube video, he explained, "I had very low insulin because I wasn’t eating carbohydrates, and the protein I consumed wasn’t insulinogenic enough."

While some diabetics report improved blood sugar control on the carnivore diet, its effects vary based on individual metabolic responses. For non-diabetics, low insulin can lead to hypoglycemia, causing symptoms like dizziness, confusion, a racing heart, and, in extreme cases, seizures or coma. Mild cases can be managed with fast-acting carbohydrates like juice or candy, but severe episodes require medical attention.

His Blood Test Results Showed Concerning Imbalances

Lab tests revealed that his magnesium levels were low, while his sex hormone-binding globulin (SHBG) was elevated—both potential red flags for long-term health issues.

A magnesium deficiency can cause numbness, tingling, fatigue, nausea, headaches, and muscle cramps. Since cramps often strike at night, low magnesium may also contribute to sleep disturbances.

High SHBG levels indicate an excess of circulating protein in the blood, which can increase the risk of heart disease, osteoporosis, and depression. To counteract these imbalances, introducing more magnesium-rich foods—such as leafy greens, nuts, beans, and yogurt—could be beneficial.

He Felt Cold All The Time

Electrolyte imbalances and metabolic disruptions can even affect body temperature, which Dr. Saladino experienced firsthand. "I was always cold,"he shared in his YouTube video.

Upon testing his thyroid function, he discovered that his total T3 and free T3 hormone levels were "not ideal." These hormones regulate metabolism, and low levels can slow down metabolic processes, leading to cold intolerance.

A simple strep throat infection, can trigger sudden skin inflammation, leading to psoriasis, particularly in children and young adults, according to a study.

Researchers from the Karolinska Institutet in Sweden showed that a strep throat infection caused by the Group A Streptococcus (GAS) bacterium, can trigger guttate psoriasis by altering the behavior of key immune cells. Guttate psoriasis is an often sudden-onset form of psoriasis with small, red, "drop-shaped" scaling spots on arms and legs.

While neutrophils -- the most common type of immune cell -- are the first immune cells to respond to GAS infection, the study showed that during a streptococcal infection, the immune cells behavior changes depending on their environment.

Notably, among people with guttate psoriasis, the neutrophils presented with antigens -- fragments of pathogens that signal and guide other immune cells -- get accumulated. Once accumulated, the immune cells activated the T cells, leading to inflammation, explained the researchers in the paper, published in the journal eBioMedicine.

"Doctors have long known that strep throat can precede guttate psoriasis, but the biological explanation has been unclear," said Avinash Padhi, first author of the study and Research Specialist at the Division of Dermatology and Venereology, at Karolinska.

"Our findings suggest a link between infection and skin inflammation through the accumulation of antigen-presenting neutrophils in patients' skin," Padhi added.

How Cells Shape Immune Response

Magdalini Lourda, senior author of the study and senior research specialist at the Department of Laboratory Medicine, noted that the "results challenge the traditional view of neutrophils as simple first-line defenders".

The findings show that the neutrophils play "a wider role in shaping immune responses, which may be important when designing future treatments."

How Was The Study conducted?

To find how neutrophils work in psoriasis, the blood neutrophils from psoriasis patients were compared with those from healthy individuals. Blood neutrophils from patients with severe strep-related lung inflammation were also compared.

What Is Guttate Psoriasis?

Guttate psoriasis is a distinct form of acute-onset psoriasis. It is an inflammatory skin disease characterized by the sudden appearance of red, scaly, and smaller skin lesions widespread over the body.

The condition typically follows an infection, most commonly tonsillitis caused by Group A Streptococcus (GAS). Adolescents and young adults are the most affected. It accounts for about 2 per cent of all cases of psoriasis.

Genetics, environmental triggers, such as an upper respiratory tract infection, and the onset of an inflammatory condition in a distant organ are the major risk factors.

The condition may be diagnosed by skin biopsy, throat swab culture, and blood tests.

Hangover star Ken Jeong's wife Tran Ho Jeong in 2007 discovered a hard lump in her breast while she was breastfeeding their newborn twins Alexa and Zooey. She was diagnosed with stage 3 triple negative breast cancer (TNBC) in 2008.

What Is Stage 3 Triple Negative Breast Cancer?

As per the American Cancer Society, it is an advanced aggressive, and fast-growing cancer that has spread to nearby lymph nodes or tissue, however, does not distant organs. It is characterized by the absence of estrogen, progesterone and HER2 receptors, which requires a combined approach of chemotherapy, surgery, and sometimes also radiations As per the American Cancer Society, TNBC accounts for about 10 to 15 per cent of all breast cancers.

At stage 3, TNBC has grown extensively and invaded nearby tissues and is likely to spread to lymph nodes. However, it has not metastasized to distant organs.

Hangover Star Ken Jeong's Wife Cancer Journey

As doctors said, for Tran, it was a "year of hell". She underwent 16 rounds of chemotherapy when Ken was filming The Hangover. This was then followed by a mastectomy and radiation therapy.

"I am going to survive this. I am going to fight. I have to live for the girls and for Ken," she said. After two years of battle, Tran was finally declared cancer free in 2010. Ken called it "the greatest moment" of his life.

What Happens In Breast Cancer?

As per the World Health Organization (WHO), breast cancer is the most common cancer globally with around 2.3 million new cases every year. At the rate of 1 in every 8 person in both sexes and a quarter of all cancer in women with 70% mortality occurs due to constrained resources.

It is a disease where abnormal breast cells grow out of control and form tumors. If it is left unchecked, the tumors can spread throughout the body and become fatal.

It originates in the milk ducts or the milk-producing lobules of the breast. The earliest form is not life-threatening and can be detected in the early stages. Cancer cells can spread into nearby breast tissue and create tumors that cause lumps or thickening. These invasive cancers can spread to nearby lymph nodes or other organs and metastasis can be life-threatening and fatal.

Signs And Symptoms Of Breast Cancer

The common signs are:

• A breast lump or thickening, often without pain
• Change in size, shape or appearance of breasts
• Dimpling, redness, pitting or other changes in the skin
• Change in nipple appearance or the skin surrounding the nipple (areola)
• Abnormal or bloody fluid from the nipple

Treatment

The treatment depends on the stages and subtypes of the cancer. However, common treatments involve:

• Surgery to remove breast tumor
• Radiation therapy to reduce recurrence of breast cancer around the breast tissues
• Medicals to kill cancer cells and prevent spread
• Therapies like hormonal and chemotherapy or targeted biological therapy

A new global analysis by the World Health Organization and its cancer research arm, the International Agency for Research on Cancer, has found that prevention could dramatically reduce cancer cases worldwide. The report estimates that 37 percent of all new cancers in 2022, about 7.1 million cases, were linked to causes that can largely be avoided.

The findings are based on data from 185 countries and 36 cancer types and were released ahead of World Cancer Day. Researchers examined 30 risk factors including tobacco use, alcohol, obesity, lack of physical activity, air pollution, ultraviolet radiation and nine cancer causing infections. The report stresses that prevention may be the single most powerful tool available to reduce the global cancer burden.

According to WHO data, tobacco remains the biggest contributor, responsible for about 15 percent of all new cancer cases globally. Infections accounted for around 10 percent while alcohol contributed to roughly 3 percent. Three cancers together made up nearly half of all preventable cases worldwide. Lung cancer was strongly linked to smoking and polluted air, stomach cancer to Helicobacter pylori infection, and cervical cancer to human papillomavirus infection.

WHO cancer control experts said the analysis shows clearly how much cancer risk comes from factors people and governments can act on before the disease even develops.

Differences between men, women and regions

The report shows clear gender differences. Preventable cancer accounted for 45 percent of new cases among men compared with 30 percent among women. Among men, smoking alone contributed to 23 percent of new cancers followed by infections at 9 percent and alcohol at 4 percent. Among women, infections were the largest contributor at 11 percent, followed by smoking at 6 percent and high body mass index at 3 percent.

The burden also varied widely across regions. In women, preventable cancers ranged from 24 percent in North Africa and West Asia to 38 percent in sub Saharan Africa. Among men, East Asia had the highest share at 57 percent while Latin America and the Caribbean recorded the lowest at 28 percent. Researchers say these differences reflect lifestyle habits, environmental exposures, workplace safety standards and public health policies.

The WHO report highlights practical steps that could reduce cancer cases. These include stronger tobacco control laws, limits on alcohol use, vaccination against HPV and hepatitis B, improved air quality, safer workplaces and promotion of healthier diets and physical activity.

Health officials say coordinated action across sectors such as transport, education, labour and energy can prevent millions of cancer diagnoses and lower long term healthcare costs while improving overall population health.