Quademic 2025: Hospitals in the United States are dealing with a surge in patients admission, the reason is the quademic it is dealing with at this moment. This has led to an influx of patients. It is all caused by seasonal infections, including common flu, Covid-19, and respiratory syncytial virus (RSV) that dominate the winter season in the US. This year, norovirus also joined the list, which has further increased the load on the healthcare.

The healthcare company founded in academics M Health Fairview, confirmed that their hospitals are overflowing due to the quademic.

Is US able to cope with Quademic 2025?

The hospitals of M Health Fairview's volume is up by 30% and as a results, patients are being treated in the hallways and in alternative care areas. There is also a longer wait time and shortages for resources that are required to treat these emergencies. This has also impacted other life-threatening emergencies like heart attacks and strokes, as the healthcare resources and caregivers are occupied with the surge in seasonal cases.

ALSO READ: Birmingham Struggles With 4 Different Virus Hits, Know What They Are

What are these quademic infections?

Common cold and flu: The common cold and influenza (flu) are perhaps the most well-known illnesses that peak during the fall. As temperatures drop and humidity levels fluctuate, viruses that cause colds and the flu become more active. The flu, in particular, can be more severe than a common cold, leading to complications such as pneumonia, especially in vulnerable populations like the elderly and those with pre-existing health conditions. Symptoms include a runny nose, sore throat, coughing, fever, and body aches.

Covid-19: As per the World Health Organization, Coronavirus disease or COVID-19 is an infectious disease caused by the SARS-CoV-2 virus. Most people infected with this virus will experience mild to moderate respiratory illness and recover without requiring special treatment, However, there could be some cases of seriously ill patients who may require medical attention. It is also because of the other existing medical conditions like cardiovascular diseases, diabetes, chronic respiratory diseases, cancers, or older age.

The best way to protect against this virus is by following social isolation form those who are infected, using mask to prevent droplets from infecting others when you cough or sneeze and to wash your hands for 20 seconds frequently.

RSV or Respiratory Syncytial Virus: As per the Centers of Diseases Control and Prevention (CDC), RSV is a common respiratory virus that infects nose, throat and lungs. Though symptoms are similar to the viruses like flu or COVID-19, the disease in itself is different. It also peaks during the winter season, especially between December and January.

However, the main difference between RSV and other respiratory illness, above mentioned is that RSV can cause pneumonia or bronchiolitis, especially for those who are over the age of 50 or with an existing heart or lung disease.

Norovirus: It is a number 1 cause of foodborne illness in the US and this happens when virus gets into the food and then it accidentally enters your mouth. These particles are from faeces or vomit from infected people, or can be transmitted via contaminated food and water. It could also spread by touching unclean surfaces like door handles or cutlery.

For most people, having norovirus is unpleasant, but mild and recovery could be made in 1 to 2 days. However, it could be more serious for babies, older people and anyone with any existing health condition.

The US Food and Drug Administration (FDA) has approved Tivicay PD tablets for oral suspension (dolutegravir) to treat HIV infection in babies.

Developed by ViiV Healthcare, Tivicay and Tivicay PD were previously approved for adults and children older than four weeks.

Now, Tivicay PD has been approved for newborns from birth up to four weeks of age weighing at least 2 kg, in combination with other antiretroviral agents.

How Does Tivicay Work?

Tivicay and Tivicay PD contain dolutegravir, an integrase strand transfer inhibitor used in combination with other antiretroviral agents to treat HIV.

Integrase inhibitors inhibit HIV integrase by binding to the integrase active site and blocking the strand transfer step of retroviral deoxyribonucleic acid (DNA) integration, which is essential for the HIV replication cycle.

Also read: US Measles Outbreak: Pennsylvania Reports First Deaths Of 2026 As Trump Pushes Back On Vaccines

What’s The Evidence For Tivicay PD In Newborns?

The FDA approval was based on data from the IMPAACT 2023 study, in which 48 newborns exposed to HIV-1 and weighing at least 2 kg received Tivicay PD from birth for up to six weeks, in combination with standard-of-care antiretroviral medications to prevent mother-to-child HIV transmission.

The newborns were followed for 16 weeks. Results showed that Tivicay PD drug levels in newborns were similar to those associated with efficacy in adults.

Importantly, the drug’s safety profile in newborns was also similar to that observed in older pediatric and adult patients.

FDA Priority Review

Read More: Reducing Mother-To-Child HIV Transmission To Zero Key To End AIDS In India: Experts

In June, the FDA accepted a supplemental new drug application (sNDA) for Tivicay PD that would extend its use to newborns from birth. The agency granted the application Priority Review with a PDUFA action date of August 25, 2026.

"Early HIV treatment can help shape a child's future, yet newborns have historically had the fewest age-appropriate treatment options," said Jean van Wyk, chief medical officer at ViiV Healthcare, at the time.

Who Should Avoid Tivicay or Tivicay PD?

Patients should not receive Tivicay or Tivicay PD if they have had previous allergic reactions to the drug or if they are also receiving dofetilide.

Serious allergic reactions have been reported. Patients should be monitored for liver damage. Immune reconstitution syndrome has also been reported in patients treated with combination antiretroviral therapy.

Taking Tivicay or Tivicay PD with certain other medications may cause the drug to stop working against HIV or lead to serious side effects. Patients or their caregivers should tell their healthcare provider about all medications they are taking before starting Tivicay or Tivicay PD.

Tivicay tablets and Tivicay PD tablets for oral suspension are not substitutable on a milligram-per-milligram basis.

What Is HIV?

HIV (human immunodeficiency virus) attacks the body's immune system, increasing the chances of developing serious infections or cancer. Without treatment, HIV can lead to AIDS (acquired immunodeficiency syndrome).

There is no cure for HIV, but prevention and treatment options are available.

Preventing Mother-to-Child HIV Transmission

Pediatric HIV remains a global issue, with children disproportionately affected by the HIV epidemic. The latest statistics show there are 1.7 million children living with HIV, and the majority of AIDS-related deaths among children still occur during the first five years of life.

Major obstacles persist for children, such as continued mother-to-child transmission, the availability of HIV testing, slow initiation of treatment, and poor availability of optimized pediatric formulations of antiretrovirals, according to UNAIDS.

An HIV-positive mother can pass the virus to her baby during pregnancy, labor, delivery, or breastfeeding, but proper medical care lowers this risk to less than 1%.

The deaths of three patients in experimental gene-editing and cell-therapy trials in China, including two children, have raised grave concerns about patient safety, transparency and oversight in the country's clinical-trial system.

The three deaths occurred in separate investigator-initiated trials (IITs), which are studies led by researchers or medical institutions rather than conducted through the conventional drug-development pathway.

The cases have come to light only months after the deaths, prompting US lawmakers to ask the FDA to scrutinise clinical data generated in China more closely.

Three Patients Died In Separate Experimental Trials

One case involved a 6-year-old girl with Snijders Blok-Campeau syndrome, a rare neurodevelopmental disorder. She died seven days after receiving an experimental gene-editing treatment at Xinhua Hospital in Shanghai in May 2025.

Reports said the treatment was delivered into the spinal fluid, and the hospital's ethics board later determined that the death was definitely related to the treatment.

A second death involved a boy with Duchenne muscular dystrophy (DMD) who received HuidaGene Therapeutics' experimental CRISPR-based therapy. He died in August 2025 after developing acute respiratory distress syndrome (ARDS) during a severe immune reaction following a high dose of the viral-vector treatment. The company disclosed the death in August 2026 after questions from reporters.

The third case involved a man in his 50s with scleroderma, who died in March 2026 after receiving RiboX Therapeutics' experimental in-vivo CAR-T therapy.

RiboX had announced FDA clearance to begin testing the treatment in the US shortly before the death became public.

Also read: Early Trial Examines A One-Time Treatment That Could Replace Statins To Manage High Cholesterol: Study

Why Gene Therapy Can Trigger Serious Reactions?

High doses can further increase this risk. In the HuidaGene case, the child developed ARDS during what the company described as a severe immune reaction. Such reactions can cause widespread inflammation and damage organs, making them potentially life-threatening.

Gene editing also carries another category of risk: the treatment is intended to alter genetic material, so researchers must carefully assess whether editing occurs only at the intended target and whether the delivery system itself creates additional risks.

Also read: UK Plans £22 Million Mini Human Organs Project To Cut Down Animal Testing In Science

Bigger Concern Is Trial Oversight

The deaths have attracted particular attention because they occurred in trials initiated by investigator, which have historically offered researchers a faster route to testing experimental therapies.

Unlike conventional clinical trials, these studies have operated under a different regulatory framework in China. Reports have raised concerns about whether independent safety monitoring was adequate in some cases.

For example, the HuidaGene trial did not have an independent data safety monitoring board, according to reporting by STAT. The study enrolled four boys, and the child who died was the fourth participant to receive treatment and received the highest dose administered in the trial.

US Lawmakers Are Calling For Greater Scrutiny

The cases have prompted Representatives John Moolenaar and Ben Cline to ask the FDA to stop accepting Chinese clinical-trial data for US drug applications unless the agency has recently inspected the trial site.

In a letter to Acting FDA Commissioner Kyle Diamantas, the lawmakers said, “American families deserve confidence that the treatments approved in our country are supported by data produced with rigor, ethics, and accountability.”

At least 1 in 4 former NFL players who died between 2016 and 2021 had chronic traumatic encephalopathy (CTE), according to a new study published in the BMJ. Researchers say the figure may be a conservative estimate, raising concerns about the long-term effects of repeated head impacts in American football.

The study examined 878 former NFL players who died during the six-year period. Of them, 235 had donated their brains for research, and 215, or 91.5%, were found to have CTE.

As brain donation was not available for everyone who died, researchers calculated that at least 24.5% of the entire group had CTE. Researchers say the actual number could be substantially higher.

What Is CTE?

Repeated head impacts can cause abnormal accumulation of tau protein in the brain. Over time, these changes can damage and kill brain cells, particularly in areas involved in memory, thinking, mood and behaviour.

The damage is not always caused by one dramatic concussion. Researchers focus on the cumulative burden of repeated head impacts, including hits that may not cause obvious concussion symptoms.

Also read: US Measles Outbreak: Pennsylvania Reports First Deaths Of 2026 As Trump Pushes Back On Vaccines

Brain Damage Can Build Up Over Years

CTE can be associated with symptoms including memory problems, confusion, impaired judgement, depression, anxiety, aggression and difficulties controlling impulses.

The new study also found a strong relationship between more advanced CTE and dementia. Among players with the most severe, Stage IV disease, dementia was particularly common.

Dr Daniel Daneshvar, a neurologist at Mass General Brigham and lead author of the study, said, "Former NFL players had about a fourfold higher risk of dying from neurodegenerative disease compared with the general population."

Also read: Delhi H1N1 Cases Cross 2,300: No New Strain, Flu Mostly Self-Limiting, Says ICMR Chief

The Risk May Begin Before The NFL

One important finding is that the brain injury associated with CTE does not necessarily begin during an NFL career.

Players may accumulate thousands of head impacts during childhood, high school and college football, before ever reaching the professional level.

Researchers therefore say prevention needs to focus on reducing repetitive head impacts throughout a player's sporting career, rather than concentrating only on professional football.

This also explains why researchers distinguish between concussions and repetitive head impacts. A player can experience numerous hits without being diagnosed with a concussion, yet the cumulative exposure may still have a lasting impact in long term.

Can CTE Be Detected Or Treated While Someone Is Alive?

One of the biggest challenges is detecting CTE while someone is alive. There is currently no definitive test that can diagnose CTE during life and no cure that can reverse the underlying brain changes.

Researchers are studying biomarkers and brain-imaging techniques that could eventually make diagnosis possible without an autopsy. The treatment focuses on managing symptoms like depression, sleep problems, headaches, cognitive difficulties and behavioural changes.