Fasting may reset your body, but can it reset your mind? The new trend of dopamine fasting claims it can. And wait, there's more. This trend also works against dopamine resistance, implying that things that did not make you happier before will now do. You see, dopamine is a part of the brain's reward system and plays an important role in your pleasure reception. While this neurotransmitter is not directly linked to an individual's happiness, it triggers feelings of satisfaction, motivation and pleasure.

However, a person can also reach a stage of dopamine resistance if they continue to indulge in activities that trigger its frequent or constant release. In this case, the individual stops feeling the impact of this neurotransmitter and thus, does feel good or happy.

So does dopamine fasting work?

Dopamine fasting is a practice where individuals limit their exposure to activities or stimuli that typically provide a surge of dopamine. The idea behind dopamine fasting is to reset or recalibrate the brain's reward system. This is usually done by abstaining from gratifying things or experiences like social media, junk food, and even sex. Proponents of dopamine fasting argue that continual overstimulation from digital devices, social media, and easily accessible indulgences has numbed our brain's reward pathways. By regularly denying ourselves these dopamine triggers, the idea claims, we might restore our ability to acquire fulfilment from life's basic pleasures.

How Does Dopamine Imbalance Affect Your Mental Health?

Having low levels of dopamine can make you less motivated and excited about things. In Parkinson's disease, there is not enough dopamine in the areas of the brain important for movement. This leads to problems with muscle stiffness and movements such as walking.

The symptoms of a dopamine imbalance depend on what is causing the problem. They include physical symptoms such as:

• muscle cramps, spasms or stiffness
• digestion problems, such as constipation or reflux
• pneumonia
• trouble sleeping
• moving or speaking more slowly than usual

• feeling tired and unmotivated, or sad and lacking hope
• having low libido (sex drive)
• hallucinations (experiencing something that's not real)

How Can I Adjust My Dopamine Levels?

Adjusting dopamine levels is complicated, as it is involved in many different roles in the brain. Your doctor won't measure your dopamine levels directly, and there is no simple test to measure it. Your symptoms will be the clues that tell your doctor if you have too much or not enough dopamine. They will then prescribe medicines to adjust your dopamine level, based on your symptoms, and make adjustments based on how your body responds and how you feel.

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Keeping your cholesterol levels in a healthy range is one of the best things you can do for your heart. High cholesterol is a major risk factor for heart disease, but the good news is that what you eat can make a significant difference. While some people may need medication, research shows that certain foods can naturally help lower LDL cholesterol and support overall cardiovascular health.

One of the easiest places to start is with oats. Oats are packed with a soluble fiber called beta-glucan, which helps reduce the amount of cholesterol absorbed into your bloodstream. A review published in Nutrients found that regularly eating oat beta-glucan can lead to meaningful reductions in LDL cholesterol, especially when combined with an overall heart-healthy diet.

Legumes such as beans, lentils, and chickpeas are another powerful addition to your plate. They're rich in fiber and plant-based protein, making them an excellent alternative to processed meats and other foods high in saturated fat. Research has consistently linked regular legume consumption with lower LDL cholesterol levels and better heart health.

Nuts also deserve a place in a cholesterol-friendly diet. Almonds, walnuts, and other tree nuts provide healthy unsaturated fats, fiber, and antioxidants. According to studies published in the American Journal of Clinical Nutrition, moderate nut consumption can help improve cholesterol levels and support cardiovascular health.

Fatty fish like salmon, sardines, and mackerel are well known for their heart-protective benefits. These fish are rich in omega-3 fatty acids, which can help lower triglycerides and support healthy blood vessels. The American Heart Association recommends eating fatty fish at least twice a week as part of a balanced diet.

Fruits and vegetables remain some of the most important foods for maintaining healthy cholesterol levels. Apples, berries, oranges, leafy greens, and broccoli provide fiber, vitamins, antioxidants, and plant compounds that help protect the heart. Numerous studies have shown that diets rich in fruits and vegetables are associated with a lower risk of cardiovascular disease.

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Avocados are another heart-smart choice. They contain monounsaturated fats and fiber, both of which can help improve cholesterol levels when used in place of foods high in saturated fat. A clinical study published in the Journal of the American Heart Association found that people who ate one avocado daily experienced greater reductions in LDL cholesterol than those following similar diets without avocado.

The bottom line is that controlling cholesterol doesn't require a drastic diet overhaul. Small, consistent changes—such as eating more whole grains, legumes, nuts, fruits, vegetables, fatty fish, and healthy fats—can have a lasting impact on heart health. Combined with regular exercise and other healthy lifestyle habits, these foods can help keep your cholesterol in check and support long-term well-being.

Sleep is one of the most important factors for overall health and well-being, influencing both physical and mental health. Yet, how much sleep a person actually needs remains a common topic of debate.

Dr Sudhir Kumar, a neurologist at Apollo Hospitals, addressed several misconceptions and shared evidence-based insights about sleep that everyone should know.

In a detailed post on social media platform X, Dr Sudhir said that most adults need 7–9 hours of sleep per night.

While some may function well with slightly less or more sleep, he noted that "regularly sleeping less than six hours or more than 9–10 hours is associated with adverse health outcomes."

Sleep Consistency Matters Too

While sleep duration is important, sleep consistency is equally important.

"Going to bed and waking up at roughly the same time every day helps regulate your circadian rhythm," he said.

Irregular sleep schedules, on the other hand, are associated with poorer metabolic health, mood disturbances, and daytime sleepiness.

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Monophasic vs Biphasic Sleep

Dr Sudhir said that most modern adults follow a monophasic pattern, with one main sleep period at night.

However, "a biphasic pattern (night sleep plus a short afternoon nap) can also be healthy if total sleep duration is adequate and the nap does not interfere with nighttime sleep."

Does Everyone Need an Afternoon Nap?

Not necessarily, said Dr Sudhir, popularly known as Hyderabaddoc on X, adding that many healthy adults do perfectly well without naps.

However, naps may be particularly useful for:

• Shift workers

• People with sleep debt

• Older adults with increased daytime sleepiness

• Those performing safety-critical tasks requiring sustained alertness

Further, he said that a 10–30-minute nap, also known as a power nap, is usually best, and may help:

• Improve alertness

• Improve concentration

• Reduce fatigue

• Enhance performance

However, naps lasting more than an hour may cause "sleep inertia" (grogginess) and disrupt nighttime sleep in some individuals.

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Night Shift Work And Health Impacts

"Night shift work is not biologically normal," Dr Sudhir said.

Humans are programmed to be awake during the day and asleep at night. Long-term night shift work has been associated with increased risks of:

• Obesity

• Type 2 diabetes

• Cardiovascular disease

• Mood disorders

• Workplace accidents

Sleep During Weekends

Dr Sudhir also addressed the common belief that people can make up for lost sleep during weekends.

While "partial recovery is possible," he said weekend catch-up sleep does not fully reverse the effects of chronic sleep deprivation.

Large shifts in sleep timing during weekends, often referred to as "social jet lag," can disrupt circadian rhythms.

He advised keeping wake-up and bedtime within about one to two hours of the weekday schedule.

He also warned against relying on multiple alarms every morning, which according to him "suggests insufficient sleep, poor sleep quality, and circadian misalignment."

How Inadequate Sleep Can Affect You

Dr Sudhir said regularly sleeping more than 9–10 hours may be associated with higher risks of cardiovascular disease, depression, frailty, and mortality.

At the same time, the neurologist noted that "even one night of inadequate sleep can impair performance".

Short-term sleep deprivation can lead to:

• Reduced attention

• Slower reaction time

• Poor decision-making

• Mood changes

• Increased accident risk

Chronic insufficient sleep is associated with:

• Hypertension

• Type 2 diabetes

• Obesity

• Cardiovascular disease

• Depression and anxiety

• Cognitive decline

• Reduced quality of life

"Sleep is a fundamental biological requirement, just like nutrition and exercise," Dr Sudhir said.

GLP-1 receptor agonists (GLP-1 RAs), including semaglutide widely used to improve diabetes control and promote weight loss, may also reduce the risk of colorectal cancer, according to a new study.

The study found that the effect was particularly notable among people with inflammatory bowel disease (IBD), as well as those with both IBD and type 2 diabetes. Both conditions are associated with a higher risk of colorectal cancer due to chronic inflammation and metabolic changes that may promote tumor development.

"GLP-1 RA use was associated with a significantly reduced incidence of colorectal cancer in all patients with IBD, as well as the subpopulation with both IBD and type 2 diabetes," said lead author Sarina Ailawadi of Case Western Reserve University, US.

"Given the elevated colorectal cancer risk in IBD, these findings suggest a potential protective effect of GLP-1 RA use in this high-risk population. Prospective studies will be important to further analyze and confirm this potential benefit," she added.

The findings will be presented at the 2026 American Society of Clinical Oncology (ASCO) Breakthrough meeting, scheduled for June 25–27 in Singapore.

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How Was The Study Conducted?

This retrospective cohort study analyzed data from 69,221 people in the US, including GLP-1 RA users and non-users.

Researchers also identified 209,649 people with both IBD and type 2 diabetes, including 38,567 who had taken a GLP-1 RA.

After matching users and non-users for various characteristics, data from 37,740 patients were analyzed. The GLP-1 RA group included people taking semaglutide, dulaglutide, tirzepatide, exenatide, liraglutide, or lixisenatide.

The researchers compared the five-year incidence of colorectal cancer between GLP-1 RA users and non-users.

Among people with IBD, the five-year incidence of colorectal cancer was 0.2% in GLP-1 RA users compared with 0.42% in non-users. The odds ratio was 0.49, indicating a 51% lower likelihood of developing colorectal cancer among GLP-1 RA users.

Among patients with both IBD and type 2 diabetes, the five-year incidence of colorectal cancer was 0.31% in GLP-1 RA users and 0.57% in non-users. The odds ratio was 0.54, suggesting a 46% lower likelihood of developing colorectal cancer.

The researchers noted that prospective studies are needed to confirm the potential protective effect of GLP-1 RAs on colorectal cancer risk.

Do IBD and Type 2 Diabetes Increase Colorectal Cancer Risk?

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Inflammatory bowel disease is associated with a higher risk of colorectal cancer, likely because of chronic inflammation in the intestines. People with IBD are estimated to be six times more likely to develop colorectal cancer than those without the condition.

Type 2 diabetes, the most common form of diabetes, also increases colorectal cancer risk and is becoming more common among people with IBD. Scientists believe that individuals with both conditions may face an especially high risk because of the combined effects of chronic inflammation and metabolic dysfunction.

What Are GLP-1 Receptor Agonists?

GLP-1 receptor agonists are a class of drugs that help lower blood sugar levels and promote weight loss. Originally developed to treat type 2 diabetes, many are now widely used for weight management.

These medications mimic the action of the GLP-1 hormone by stimulating insulin release, slowing digestion, and increasing feelings of fullness.

Beyond blood sugar control and weight loss, GLP-1 RAs have been linked to several health benefits, including lower blood pressure and reduced cardiovascular risk. Previous studies have also suggested that they may lower the risk of colorectal cancer and other obesity-related cancers.

However, their specific impact on colorectal cancer risk among people with IBD has remained unclear until now.