Happiness is influenced by a complex interplay of various chemicals in our brain, particularly four key neurotransmitters, D.O.S.E or Dopamine, Oxytocin, Serotonin, and Endorphins. These chemicals, often referred to as "happiness chemicals," are responsible for creating feelings of joy, motivation, connection, and calm.

However, when there's a deficiency in any of these, it can significantly affect our mood, energy, and overall well-being. Let’s dive into what these four neurotransmitters are, how their deficiency impacts us, and how we can boost their levels naturally.

Dopamine: The Motivation and Reward Chemical

Dopamine is often called the "motivation molecule." It plays a major role in enabling motivation, learning, and the pleasure-reward system in the brain. When we accomplish something — whether it’s finishing a project, completing a workout, or achieving a goal — dopamine gives us that sense of satisfaction and determination to continue.

Deficiency Effects:

When dopamine levels are low, it can lead to procrastination, low self-esteem, lack of focus, and general fatigue. A person might feel anxious, hopeless, or experience mood swings because the brain isn’t getting the reward signals it needs.

Boosting Dopamine:

You can increase dopamine levels by setting and achieving small goals, exercising regularly, eating foods rich in L-Tyrosine (such as almonds, avocados, and eggs), and practicing mindfulness or meditation. Engaging in creative activities like writing or drawing also helps boost dopamine levels.

Oxytocin: The Bonding Chemical

Oxytocin is often referred to as the "love hormone" or "cuddle hormone" because it plays a major role in social bonding and trust. It’s released when we hug, touch, or engage in other forms of physical affection. Oxytocin fosters feelings of connection and emotional intimacy, making it essential for relationships, family bonding, and even team cooperation.

Deficiency Effects:

A lack of oxytocin can lead to feelings of loneliness, stress, anxiety, and difficulties in forming or maintaining relationships. Low oxytocin levels are associated with feelings of isolation and disconnection from others.

Boosting Oxytocin:

You can raise your oxytocin levels through physical touch, socialising, spending quality time with loved ones, and even engaging in activities like massage or listening to soothing music. Acts of kindness, such as helping others or volunteering, also help release oxytocin.

Serotonin: The Mood Stabiliser

Serotonin is responsible for feelings of well-being and contentment. It helps regulate mood, sleep, digestion, and even social behavior. People who have balanced serotonin levels often feel calm, confident, and emotionally stable. Serotonin is crucial in helping people feel valued and significant among their peers.

Deficiency Effects:

Low serotonin levels are linked to depression, low self-esteem, irritability, and mood swings. Individuals may feel overly sensitive to criticism, experience panic attacks, or struggle with social phobias when serotonin is deficient.

Boosting Serotonin:

You can boost serotonin by getting regular exercise, exposing yourself to sunlight, engaging in cold showers or massages, and practicing mindfulness. Simple activities like walking in nature, meditating, or doing yoga are also effective serotonin enhancers.

Endorphins: The Pain Reliever

Endorphins are the body’s natural painkillers. Released in response to stress, pain, or intense physical activity, they help alleviate discomfort and promote a sense of euphoria. Endorphins are what make you feel good after a workout or a hearty laugh, often referred to as the "runner's high."

Deficiency Effects:

Without enough endorphins, people may experience anxiety, depression, chronic pain, and insomnia. A deficiency in endorphins can make daily life feel overwhelming and physically draining.

Boosting Endorphins:

To boost endorphins, engage in laughter, exercise, and stretching activities. Eating spicy foods or dark chocolate can also stimulate endorphin production. Regular massage therapy and meditation are other ways to naturally elevate endorphin levels.

Polycystic ovarian syndrome (PCOS), now renamed polyendocrine metabolic ovarian syndrome (PMOS), can begin during adolescence and affect metabolic health, fertility and mental health, AIIMS experts said.

Speaking at a press conference in Delhi, the experts discussed PCOS risk factors, diagnosis in teenagers and the role of lifestyle management.

Obesity and sedentary habits can increase risk, but irregular periods or polycystic-looking ovaries on ultrasound do not automatically mean PCOS. Menstrual irregularity and ovarian changes can be normal during adolescence, making accurate diagnosis important.

Irregular Periods: When Is It Abnormal?

Irregular periods are common in the first year after menstruation begins. Dr. Rajni Sharma, Professor, Division of Pediatric Endocrinology, Department of Pediatrics, AIIMS, said: “It is normal and physiological.”

However, persistent irregularity should be evaluated.

“But if they are irregular even after one year, like their duration is coming in between, duration more than 45 days up to 3 years, or after menarche, after 3 years up to 35 days cycle, or less than 21 days cycle, or less than 8 times per year cycles, or their gap is more than 3 months, then we should think that they are irregular and they should be investigated,” she said.

Also read: Why Rebranding PCOS As PMOS Could Mark A New Era In Women’s Health

PCOS Diagnosis: Ultrasound May Mislead

Ultrasound is not routinely used to diagnose PCOS in adolescents because polycystic-looking ovaries can be normal during this stage, Dr. Rajni said.

Dr. Renu Sharma, Child Psychologist, Department of Psychiatry, AIIMS, said such findings can also cause unnecessary anxiety.

“Many times, many families come out of fear because there is a polycystic appearance in an ultrasound.”

Some girls may have PCOS-like features without meeting the diagnostic criteria and may instead be considered at risk.

“We call it at risk of PCOS. At this stage, it is best to focus on diet and lifestyle.”

What Raises PCOS Risk?

Family history, obesity, type 2 diabetes and lifestyle factors can increase PCOS risk, Dr. Rajni said.

“Especially if there is type 2 diabetes, obesity, all these things are there, or mother, or her aunt had PCOS, then the risk increases.”

Poor diet and physical inactivity can also contribute.

“They are not eating fiber, fruits, vegetables. And they are consuming more junk food. And, one is, sedentary activity,” she said.

However, PCOS can also occur in girls with normal weight. “Many normal girls can also have it. Normal weight girls.”

Facial Hair Can Affect Mental Health

Facial and body hair can affect self-image and self-esteem in adolescent girls with PCOS, Dr. Renu said.

“These young adolescent girls suffering from PCOS have very significant psychosocial issues," said the expert, adding that anxiety and depression are very common.

They also develop some eating disorders such as anorexia or bulimia, she said, noting that the adolescent's "self-perception, or self-concept, starts becoming negative.”

What Can Parents Do?

Lifestyle management is an important part of managing PCOS risk and symptoms. Dr. Vandana recommended healthier food choices and regular physical activity.

“You can make a lot of things at home, with good healthy ingredients.”

“Second, in general, you should eat more salads. You should eat more colorful fruits and vegetables, so we talk about this.”

She also stressed the importance of avoiding a sedentary lifestyle, and stressed the need for "one hour of physical activity of moderate to vigorous level daily".

“This means that, while doing that activity, you are not able to talk normally. If you can talk normally, then it means that the activity is not of moderate to vigorous level.”

Most women who've had preeclampsia remember it as something that happened during pregnancy. The blood pressure spiked, doctors kept a close watch, the baby arrived, and everything went back to normal.

Case closed, or so it seems. But there's a quieter part of this story that doesn't get told nearly enough - what preeclampsia might mean for a woman's heart years down the line.

So, What Is Preeclampsia?

It's a condition that can happen after the 20th week of pregnancy, when blood pressure rises sharply and starts putting pressure on organs like the kidneys or liver. During preeclampsia, the lining of blood vessels - the endothelium - becomes inflamed and doesn't relax and dilate the way it normally should.

This is the same vessel dysfunction we see in the early stages of coronary artery disease, just decades ahead of schedule. Doctors usually catch it through routine checks - protein in the urine, sudden swelling, or blood pressure readings that don't sit right.

Once the baby is delivered, blood pressure almost always comes back down. That "return to normal," though, doesn't mean the story is over.

Also read: Vitamin D & Pregnancy: Could Vitamin D Deficiency Increase Risk Of Premature Birth?

A Pregnancy Complication with a Long Impact on Heart

Think of preeclampsia as an early stress test that the heart didn't quite pass. It is associated with increased risk of hypertension in future and also increase the risk of heart failure, stroke and cardiovascular diseases. And this isn’t a risk that shows up only in old age, in some cases, death happens within the first 10 years after pregnancy.

The risk of heart failure also increases by four-fold and the risk of coronary heart disease by two folds in patients with preeclampsia. The risk of ischemic heart disease and hypertension is elevated too. The risk increases further if preeclampsia occurred early in pregnancy, during multiple pregnancies, or alongside other factors like obesity or a family history of heart disease.

It highlights the importance of life law monitoring of cardiovascular rest factors in a woman who has history of preeclampsia.

Also read: PMOS Isn't Just About Periods Or Pregnancy: Why Women Need To Think Beyond Fertility

The Part of Care That Often Gets Skipped

Once the baby is here, attention naturally shifts entirely toward the newborn - and a new mother's own follow-ups tend to fall away quietly, usually right after that standard six-week check. That's the gap, we need to close in postpartum care. Women with a preeclampsia history should regularly monitor their blood pressure, cholesterol and blood sugar, and actually bring these numbers up during the consultation.

None of this means preeclampsia guarantees heart disease down the road. It just means the risk picture has shifted, and that's worth knowing. Staying active, eating well, keeping weight in check, and staying away from smoking helps reduce the risk.

More obstetricians and cardiologists are starting to treat preeclampsia as something to track for life, not just for nine months. That shift in thinking could end up protecting a lot of hearts long after the pregnancy itself is over.

By Dr Waseem Farooqui, Consultant, Interventional Cardiology, Cardiac Care, Medanta Hospitals, Noida

After a brain bleed, controlling blood pressure is crucial—but is it enough to prevent another stroke? Neurologists explain why consistent BP monitoring, regular medicines, lifestyle changes, and follow-ups matter after discharge. They also share warning signs families should never ignore and when sudden BP rises require urgent medical attention.

Is Blood Pressure Control Enough After A Brain Bleed?

Dr Shubha Subramanian - Senior Consultant - Neurology - Kauvery Hospital, Vadapalani, Chennai told Health and Me, "After a brain bleed, controlling BP is extremely important, but this is only for spontaneous intracerebral haemorrhage, not in cases of an AV malformation, an aneurysm-related bleed, or a traumatic bleed, where the aetiology is different." He added, "In case of idiopathic spontaneous intracerebral haemorrhage, probably because of BP fluctuations or high BP, in that case, for secondary prevention, there will be a reduced number of bleeds if the BP is well controlled. Consistent control is very, very important."

Also Read: CagriSema Beats Lilly’s Mounjaro & Zepbound In New Trial: All About Novo’s Next-Gen Obesity Drug

After a brain bleed, patients should regularly monitor blood pressure and pulse, with diabetics also checking blood sugar at home. Periodic blood tests and ECGs may be advised. Families should watch for confusion, seizures, weakness, changes in speech, or facial drooping. Recognising these warning signs early and maintaining consistent BP control can help prevent another bleed.

The Common Mistakes That Can Raise The Risk

"Common mistakes include missing medications, not monitoring blood pressure regularly, stopping follow-up visits when they are feeling better, smoking and consuming too much alcohol, and returning too soon to strenuous activity," said Dr. Soniya Tambe, Consultant, Neurology, Fortis Hospital, Bannarghetta Road, Bengaluru. She added, "Patients also may ignore symptoms such as severe headache, weakness, speech difficulty, or vision changes. These signs should never be dismissed."

What To Eat And Avoid During Recovery

Recovery after a brain bleed doesn’t stop when a patient leaves the hospital. The steps taken at home are equally important in reducing the risk of another stroke. Along with taking medicines as prescribed and keeping blood pressure under control, patients should focus on making healthy, long-term lifestyle changes rather than following temporary restrictions.

A balanced, low-salt diet can support recovery, while smoking and alcohol should be avoided. Patients should ease back into physical activity gradually and only with their doctor’s advice, especially in the early recovery period. Getting enough sleep, maintaining a healthy weight, and managing stress are also important. Regular follow-ups help monitor blood pressure and other heart-related risk factors.

Warning Signs Families Should Never Ignore

Dr. Praveen Chander, Senior Consultant Neurology, Gleneagles Chennai, told Health and Me, "Families should also recognise sudden weakness or numbness, difficulty speaking, confusion, loss of balance, severe headache, or sudden vision changes as possible warning signs. These symptoms require immediate medical attention rather than waiting for them to settle."