Happiness is influenced by a complex interplay of various chemicals in our brain, particularly four key neurotransmitters, D.O.S.E or Dopamine, Oxytocin, Serotonin, and Endorphins. These chemicals, often referred to as "happiness chemicals," are responsible for creating feelings of joy, motivation, connection, and calm.

However, when there's a deficiency in any of these, it can significantly affect our mood, energy, and overall well-being. Let’s dive into what these four neurotransmitters are, how their deficiency impacts us, and how we can boost their levels naturally.

Dopamine: The Motivation and Reward Chemical

Dopamine is often called the "motivation molecule." It plays a major role in enabling motivation, learning, and the pleasure-reward system in the brain. When we accomplish something — whether it’s finishing a project, completing a workout, or achieving a goal — dopamine gives us that sense of satisfaction and determination to continue.

Deficiency Effects:

When dopamine levels are low, it can lead to procrastination, low self-esteem, lack of focus, and general fatigue. A person might feel anxious, hopeless, or experience mood swings because the brain isn’t getting the reward signals it needs.

Boosting Dopamine:

You can increase dopamine levels by setting and achieving small goals, exercising regularly, eating foods rich in L-Tyrosine (such as almonds, avocados, and eggs), and practicing mindfulness or meditation. Engaging in creative activities like writing or drawing also helps boost dopamine levels.

Oxytocin: The Bonding Chemical

Oxytocin is often referred to as the "love hormone" or "cuddle hormone" because it plays a major role in social bonding and trust. It’s released when we hug, touch, or engage in other forms of physical affection. Oxytocin fosters feelings of connection and emotional intimacy, making it essential for relationships, family bonding, and even team cooperation.

Deficiency Effects:

A lack of oxytocin can lead to feelings of loneliness, stress, anxiety, and difficulties in forming or maintaining relationships. Low oxytocin levels are associated with feelings of isolation and disconnection from others.

Boosting Oxytocin:

You can raise your oxytocin levels through physical touch, socialising, spending quality time with loved ones, and even engaging in activities like massage or listening to soothing music. Acts of kindness, such as helping others or volunteering, also help release oxytocin.

Serotonin: The Mood Stabiliser

Serotonin is responsible for feelings of well-being and contentment. It helps regulate mood, sleep, digestion, and even social behavior. People who have balanced serotonin levels often feel calm, confident, and emotionally stable. Serotonin is crucial in helping people feel valued and significant among their peers.

Deficiency Effects:

Low serotonin levels are linked to depression, low self-esteem, irritability, and mood swings. Individuals may feel overly sensitive to criticism, experience panic attacks, or struggle with social phobias when serotonin is deficient.

Boosting Serotonin:

You can boost serotonin by getting regular exercise, exposing yourself to sunlight, engaging in cold showers or massages, and practicing mindfulness. Simple activities like walking in nature, meditating, or doing yoga are also effective serotonin enhancers.

Endorphins: The Pain Reliever

Endorphins are the body’s natural painkillers. Released in response to stress, pain, or intense physical activity, they help alleviate discomfort and promote a sense of euphoria. Endorphins are what make you feel good after a workout or a hearty laugh, often referred to as the "runner's high."

Deficiency Effects:

Without enough endorphins, people may experience anxiety, depression, chronic pain, and insomnia. A deficiency in endorphins can make daily life feel overwhelming and physically draining.

Boosting Endorphins:

To boost endorphins, engage in laughter, exercise, and stretching activities. Eating spicy foods or dark chocolate can also stimulate endorphin production. Regular massage therapy and meditation are other ways to naturally elevate endorphin levels.

While December arrives with celebrations, food and social gatherings, it is also the time when seasonal illnesses quietly begin to surface. Colds, lingering coughs and flu tend to spread more easily in colder weather, often catching people off guard just as the new year begins. For those hoping to avoid starting January feeling unwell, there are simple steps that can be taken ahead of time.

A pharmacist has urged people to prepare early by stocking up on essential remedies, saying that being organised can help manage symptoms quickly and reduce unnecessary visits to the doctor. According to him, early action makes winter illnesses far easier to handle.

Why Pharmacists Say Preparation Matters Before January

Pharmacists say the key to getting through winter comfortably is preparation before cold and flu season reaches its peak. Keeping a well-stocked medicine cupboard means symptoms can be treated as soon as they appear, without the stress of searching for supplies while already feeling ill.

“Preparation really is half the battle,” said pharmacist Frederick Apenteng from Roseway Labs. “Once you’re unwell, the last thing you want is to be running around looking for paracetamol or trying to buy a thermometer. That’s often when people feel worse than they need to.”

Medicines To Get Ready For Winter Flu

Frederick stresses that starting with the basics is essential. Painkillers such as paracetamol or ibuprofen help manage fever, aches and general discomfort. Throat lozenges or sprays can ease soreness, while keeping two types of cough medicine at home is helpful. One should be an expectorant for chesty coughs, and the other a suppressant for dry, irritating coughs.

The Basics Every Household Should Have

Blocked noses are another common winter complaint, and decongestants can provide quick relief. However, Frederick warns they should not be used for more than five days. For longer-term congestion, saline nasal sprays are a safer option.

Other useful items include rehydration sachets, tissues, hand sanitiser, and honey and lemon for comfort. A digital thermometer allows you to keep track of fever, while vapour rubs or a humidifier can help ease breathing when congestion strikes.

Why Nutrition and Rest Matter for Immunity

Beyond medicines, Frederick highlights the role of nutrition in keeping the immune system strong. “People often feel run down because they’re missing key nutrients,” he explained. “Iron, B vitamins and vitamin C all play important roles in supporting immune defences.”

Eating foods rich in these nutrients, such as leafy greens, citrus fruits and whole grains, can make a noticeable difference. “The biggest immunity boosters are actually sleep, proper nutrition and staying hydrated,” he added.

A Little Planning Now Can Prevent Bigger Problems Later

Preparing in advance can ease both physical discomfort and mental stress. “Having your winter kit ready means you can act quickly at the first sneeze,” Frederick said. “That can stop symptoms from getting worse and helps keep you out of the GP waiting room.”

In short, early rest, basic treatment and preparation can help people move through winter with fewer disruptions.

Be Cautious With Cold and Flu Medicines

While home remedies can be helpful, it is important not to overuse certain products. In some cases, taking too many cold and flu medicines can cause serious problems, including accidental overdose, liver or kidney damage, and rebound congestion.

Always follow dosage instructions carefully and speak to a healthcare professional if you are unsure. Frederick also cautions against prolonged use of nasal decongestant sprays. Using them for more than a few days can trigger a rebound effect, where nasal passages become more blocked than before. This condition is known as rhinitis medicamentosa.

Staying informed, prepared and cautious can make all the difference during the winter months.

If you managed to stay healthy this festive season, chances are you still know at least a couple of people who did not. In the days before Christmas and in the weeks that followed, a so-called “mystery virus” has been moving rapidly across the UK.

Many people have reported coughing, sneezing, blocked or runny noses, and in some cases stomach-related problems too. So what exactly is behind this wave of illness? Ian Budd, lead prescribing pharmacist at Chemist4U, has explained which virus is currently spreading widely across the country and what steps you can take to safeguard yourself and your family. He also sheds light on its incubation period.

What Is Adenovirus?

Adenoviruses refer to a large family of viruses that can trigger infections ranging from mild to more serious, affecting different parts of the body. Most often, adenovirus targets the respiratory tract. The symptoms can closely resemble those of a cold or flu. In the majority of cases, adenovirus infections are mild and can be managed with basic care focused on easing symptoms.

Adenovirus Incubation Period

The incubation period for adenovirus usually falls between 2 and 14 days. For many people, signs such as fever, a sore throat, or coughing tend to appear around five or six days after coming into contact with the virus, although this can differ from person to person. Adenovirus spreads easily through droplets released when someone coughs or sneezes, by touching contaminated surfaces, or through fecal-oral transmission. It is highly contagious, particularly in crowded settings, and people may continue to shed the virus even after they start feeling better, according to the National Institute of Health.

One reason the virus appears to be everywhere right now is winter behaviour. Colder weather keeps people indoors for longer periods, increasing close contact with others who may already be unwell.

Ian explained, “With COVID-19 restrictions no longer in place and fewer people being exposed to common viruses over the last few years, overall immunity in the community may be lower. That makes people more vulnerable now.

“Adenovirus itself is not new. It is simply appearing more frequently at the same time as other winter illnesses.”

Adenovirus Symptoms

If you suspect you may have adenovirus, the most common symptoms include:

• Sore throat
• Runny or blocked nose
• Cough
• Fever
• Fatigue
• Headaches or body aches
• Shortness of breath, which is less common

Other possible signs:

• Pink eye, also known as conjunctivitis, causing red, watery, gritty-feeling eyes
• Ear infections, particularly among children
• Digestive symptoms such as nausea, vomiting, or diarrhoea with certain strains

Who Do Adenoviruses Affect?

Adenoviruses can infect people at any age, but they are especially common in children under the age of five. In babies and young children, the virus often spreads in daycare settings, where close contact is unavoidable. Young children are also more likely to put shared objects in their mouths and are less consistent about handwashing.

Among adults, adenoviruses tend to spread in crowded living conditions. Those who spend time in dormitories or military housing may face a higher risk. The virus can also circulate easily in hospitals and nursing homes.

People with weakened immune systems are more likely to become seriously ill if they contract adenovirus. This group includes individuals who have undergone stem cell or organ transplants, as well as those living with cancer or HIV/AIDS. Those with existing heart or lung conditions also face a higher risk of severe infection.

Women are spending thousands of pounds to address an intimate and largely unexpected side effect linked to rapid weight loss caused by so-called “fat jabs.” As these injections grow quickly in popularity, doctors say sudden and significant weight loss is leading some women to notice changes in their labia or vulva.

This has resulted in a rise in private cosmetic procedures commonly referred to as “labia puffing.” For those unversed, the vulva refers to the external female genital area, which includes the labia. The labia are the folds of skin that surround the vaginal opening.

Weight-Loss Injections Go Mainstream

Originally developed to manage Type 2 diabetes, weight-loss injections have entered the mainstream at remarkable speed. As per Mirror, in the UK alone, about 2.5 million people are now using these drugs, according to figures reported by The Telegraph in October. That means roughly one in every 20 adults. Most users access the injections privately, as they are rarely available through the NHS. The report also noted that sales of medications such as Mounjaro and Wegovy reached 2.5 million in July, marking a sevenfold increase compared to the previous year.

While headlines have largely focused on visible changes such as slimmer bodies and faces, including among celebrities like Sharon Osbourne and Serena Williams, medical professionals say other, less discussed effects are starting to emerge.

Changes Beyond Common Side Effects

Along with widely known side effects such as nausea, diarrhoea, constipation, abdominal pain, and vomiting, some women are now reporting noticeable changes in the appearance of their vulvas and labia.

Doctors explain that the issue is not weight loss itself, but the speed at which it happens. Rapid weight loss strips fat from many areas of the body, including the vulval region. For some women, this leads to a loss of volume in the labia, causing loose or sagging skin. This can result in irritation and discomfort during everyday activities such as sitting, cycling, or exercising.

Women Share Their Experiences

Many women have taken to online forums to describe what they are experiencing. As per Mirror, one Reddit user shared, “She [the gynaecologist] told me my vulva is saggy and I will continue to experience pain when biking or sitting unless I have surgery or fillers.”

Doctors say these outcomes are not surprising. Dr Michael Tahery, writing on his women’s health website, explained that “the rapid weight loss that occurs throughout the body may result in visible sagging of the labia or vagina because of overall fat and volume loss.”

He added that this sagging can be caused by loose labia, excess skin in the vaginal area, wrinkles, or a combination of these factors. “It’s also common for rapid weight loss to cause the labia to suddenly feel out of proportion compared to how it previously felt,” he noted.

Not Just a Cosmetic Concern

For many women, the impact goes beyond appearance. The loss of natural cushioning can increase friction and sensitivity, turning once-comfortable activities into painful experiences. As a result, more women are seeking help from private clinics, where corrective procedures can cost around $2,000, or approximately £1,479. The treatment, often called labia puffing, focuses on restoring volume to the outer lips of the vulva.

What Is Labia Puffing?

Speaking to The Daily Star, Dr Shazia Malik, consultant gynaecologist at The Portland Hospital, explained how the procedure works. “Labia puffing uses dermal fillers, such as hyaluronic acid or fat, to restore volume to the labia majora, which are the outer lips of the vulva,” she said. “It is a minimally invasive procedure designed to improve appearance by increasing fullness, smoothness, and symmetry.”

Dr Malik also pointed out that the demand is not limited to women using weight-loss injections. “The procedure is most commonly sought by women who want to regain a more youthful, fuller appearance due to ageing, weight loss, or childbirth,” she explained.

A Wider Impact of Rapid Weight Loss

The growing interest in these procedures highlights how dramatically weight-loss injections can change the body. Unlike gradual weight loss achieved through diet and exercise, the speed at which fat can disappear with these drugs means changes can occur in areas people do not expect. For some women, these sudden shifts are significant enough to push them toward cosmetic interventions to feel comfortable again.