Happiness is influenced by a complex interplay of various chemicals in our brain, particularly four key neurotransmitters, D.O.S.E or Dopamine, Oxytocin, Serotonin, and Endorphins. These chemicals, often referred to as "happiness chemicals," are responsible for creating feelings of joy, motivation, connection, and calm.

However, when there's a deficiency in any of these, it can significantly affect our mood, energy, and overall well-being. Let’s dive into what these four neurotransmitters are, how their deficiency impacts us, and how we can boost their levels naturally.

Dopamine: The Motivation and Reward Chemical

Dopamine is often called the "motivation molecule." It plays a major role in enabling motivation, learning, and the pleasure-reward system in the brain. When we accomplish something — whether it’s finishing a project, completing a workout, or achieving a goal — dopamine gives us that sense of satisfaction and determination to continue.

Deficiency Effects:

When dopamine levels are low, it can lead to procrastination, low self-esteem, lack of focus, and general fatigue. A person might feel anxious, hopeless, or experience mood swings because the brain isn’t getting the reward signals it needs.

Boosting Dopamine:

You can increase dopamine levels by setting and achieving small goals, exercising regularly, eating foods rich in L-Tyrosine (such as almonds, avocados, and eggs), and practicing mindfulness or meditation. Engaging in creative activities like writing or drawing also helps boost dopamine levels.

Oxytocin: The Bonding Chemical

Oxytocin is often referred to as the "love hormone" or "cuddle hormone" because it plays a major role in social bonding and trust. It’s released when we hug, touch, or engage in other forms of physical affection. Oxytocin fosters feelings of connection and emotional intimacy, making it essential for relationships, family bonding, and even team cooperation.

Deficiency Effects:

A lack of oxytocin can lead to feelings of loneliness, stress, anxiety, and difficulties in forming or maintaining relationships. Low oxytocin levels are associated with feelings of isolation and disconnection from others.

Boosting Oxytocin:

You can raise your oxytocin levels through physical touch, socialising, spending quality time with loved ones, and even engaging in activities like massage or listening to soothing music. Acts of kindness, such as helping others or volunteering, also help release oxytocin.

Serotonin: The Mood Stabiliser

Serotonin is responsible for feelings of well-being and contentment. It helps regulate mood, sleep, digestion, and even social behavior. People who have balanced serotonin levels often feel calm, confident, and emotionally stable. Serotonin is crucial in helping people feel valued and significant among their peers.

Deficiency Effects:

Low serotonin levels are linked to depression, low self-esteem, irritability, and mood swings. Individuals may feel overly sensitive to criticism, experience panic attacks, or struggle with social phobias when serotonin is deficient.

Boosting Serotonin:

You can boost serotonin by getting regular exercise, exposing yourself to sunlight, engaging in cold showers or massages, and practicing mindfulness. Simple activities like walking in nature, meditating, or doing yoga are also effective serotonin enhancers.

Endorphins: The Pain Reliever

Endorphins are the body’s natural painkillers. Released in response to stress, pain, or intense physical activity, they help alleviate discomfort and promote a sense of euphoria. Endorphins are what make you feel good after a workout or a hearty laugh, often referred to as the "runner's high."

Deficiency Effects:

Without enough endorphins, people may experience anxiety, depression, chronic pain, and insomnia. A deficiency in endorphins can make daily life feel overwhelming and physically draining.

Boosting Endorphins:

To boost endorphins, engage in laughter, exercise, and stretching activities. Eating spicy foods or dark chocolate can also stimulate endorphin production. Regular massage therapy and meditation are other ways to naturally elevate endorphin levels.

Irish Actor Michael Patrick, known for his significant role in Game of Thrones, has sadly passed away at the young age of 35.

Sharing the news in a post on social media platform Instagram, his wife Naomi Sheehan shared that Michael Patrick (whom she fondly calls Mick) died after a years-long battle with Motor Neurone Disease.

"Last night, Mick sadly passed away in the Northern Ireland Hospice. He was diagnosed with Motor Neurone Disease on 1st February 2023. He was admitted 10 days ago and was cared for by the incredible team there. He passed peacefully, surrounded by family and friends," Naomi said.

Calling Michael a "titan of a ginger-haired man", she said that “Words can’t describe how broken-hearted we are".

Naomi called Michael an "inspiration to everyone."

Also read: Dismissed as Anxiety: Terry Crew’s Wife Rebecca Shares Decade-Long Struggle With Parkinson’s

What Is Motor Neurone Disease (MND)

MND is a rare and progressive neurodegenerative disease. According to NHS UK, it causes muscle weakness that gets worse over a few months or years. It's usually life-shortening, and there's currently no cure, but treatment can help manage the symptoms.

Symptoms of MND include:

• stiff or weak hands
• weak legs and feet
• twitches, spasms, or muscle cramps (where muscles painfully tighten).

It makes everyday tasks such as climbing stairs or gripping objects difficult.

Also read: Grey’s Anatomy Star Eric Dane Dies After ALS Battle

As the disease advances, patients may develop difficulties with breathing, swallowing, and speech, along with changes in mood or personality. In later stages, walking and movement can become extremely limited.

Treatment of MND

About 1,500 people are diagnosed with MND each year, yet treatment choices remain scarce. Only a small proportion of patients currently qualify for therapies that target the disease process itself.

MND can be difficult to diagnose in the early stages. But as the symptoms get worse, it can usually be confirmed.

Tests used to help diagnose MND include:

• blood tests
• tests to check how well your nerves are working
• an MRI scan to help rule out other conditions that affect the brain and nerves

1. Amyotrophic lateral sclerosis (ALS): Early symptoms include muscle weakness in the arms and legs can cause you to trip and drop things.

2. Progressive bulbar palsy (PBP): It mainly affects muscles in the face, throat, and tongue, causing slurred speech and problems swallowing.

3. Progressive muscular atrophy (PMA): It causes weakness in the hands.

4. Primary lateral sclerosis (PLS): Leads to weak legs, sometimes with other symptoms, including speech problems.

Common treatment options for MND include:

• physiotherapy and exercises to help with muscle weakness and stiffness
• dietary advice to help you maintain weight
• speech and language therapist to help with talking
• Cognitive behavioral therapy (CBT) to help cope with emotions and feelings, such as anxiety and depression.

During the COVID-19 pandemic, the SARS-CoV-2 virus had a significant impact on the eyes, causing conjunctivitis (pink eye), with red, itchy, watery, or painful eyes.

A new study now shows that eye symptoms may also be key in understanding the severity of long COVID, a collection of symptoms that last three months or longer after your first COVID symptoms.

The new study, published in the journal Clinical Ophthalmology, showed that the new onset of eye symptoms in people with long COVID may be an indicator of more severe disease.

Also read: Long Covid Causes Lasting Brain Inflammation And Lung Injury, Reveals Study

Key Findings

Researchers from the Yale School of Medicine analyzed survey data from 595 adults who self-reported having long COVID in surveys conducted from May 2022 to October 2023. They found that nearly 60 percent of people reported new-onset of ocular symptoms.

The findings suggest that ocular symptoms in long COVID may be interpreted as vision-related manifestations that cluster with systemic post-COVID conditions. The symptoms include a new onset of :

• blurred or lost vision,
• dry eyes,
• floaters or flashes

Notably, individuals with ocular symptoms reported:

• A greater overall symptom burden,
• Financial difficulties,
• Challenges in everyday life.

Also read: Long COVID: The Story Of Those Who Are Still Dealing With Symptoms And Illnesses

What is Long COVID

Long COVID includes a wide range of symptoms or conditions that may improve, worsen, or be ongoing. While anyone who gets COVID-19 can develop Long COVID, studies have shown that some groups of people are more likely to develop Long COVID than others, including:

• Women
• People who have experienced more severe COVID-19 illness, especially those who were hospitalized or needed intensive care
• People with underlying health conditions
• People who did not get a COVID-19 vaccine

While many of the Long COVID conditions remain to be fully recognized, some people have more than one symptom that can be moderate to severe, and also impact the quality of life. According to the US CDC, they include:

• Tiredness or fatigue
• Difficulty thinking or concentrating (sometimes called “brain fog”)
• Shortness of breath or difficulty breathing
• Headache
• Dizziness on standing
• Fast-beating or pounding heart (known as heart palpitations)
• Chest pain
• Cough
• Joint or muscle pain
• Depression or anxiety
• Fever
• Loss of taste or smell

A Parliamentary Standing Committee on Health and Family Welfare has raised serious concerns about growing doctor burnout, especially among junior and senior resident doctors, and warned that it is now affecting both doctor well-being and patient safety. Noting that overworked doctors are a risk for patient safety, the panel said that fatigue-driven errors and burnout could compromise care.

To tackle this, the committee recommended that the government introduce and strictly enforce a formal “Clinical Duty Hours Regulation” policy. This should mandate fixed rest periods and monitored duty rosters, with oversight mechanisms to prevent violations, stated the panel in its 172nd report presented before the Parliament.

The recommendation comes amid growing concern over long, unregulated shifts in teaching hospitals, where residents often work extended hours with limited rest.

The panel warned that such conditions not only increase the likelihood of clinical mistakes but also contribute to burnout and mental health stress among young doctors.

What The Parliamentary Panel Said

The Panel noted that due to persistent human resource shortages, the working hours of junior and senior residents doctors often stretch from 24 to 36 hours. This increases risk of clinical errors and burnout, thereby compromising patient safety. Thus it recommended a mandatory working-hour regulatory framework:

• to minimize fatigue-induced clinical errors
• safeguard their mental and physical well-being,
• improving patient safety.

However, it noted the contractual engagement must not substitute regular appointments, as excessive reliance on contractual staff may dilute institutional accountability and continuity.

Instead, the panel has recommended adopting a "Total Support model for medical professionals" to attract and retain qualified doctors and specialists in the public health system.

Also read:India Must Integrate Technology To Build Preventive, Holistic Healthcare: Experts

What Is Clinical Duty Hours Regulation policy

The policy calls to:

• Ensure mandatory rest periods, monitored rosters.
• Ensure the presence of senior faculty in wards and in operating theatres during peak hours
• Align faculty schedules with clinical demand
• Offer Structured mentorship
• Protected teaching time for trainees to gain supervised clinical experience
• Improved working conditions, including accommodation, transportation, and administrative support, on par with the facilities afforded to senior civil servants,
• Transparent career progression with time-bound promotions.
• Integrate Yoga and the Indian Knowledge System (IKS) within the workforce to address depression and psychiatric issues.

Also read: Doctors Share Preventable Risk Factors That Can Land You in the Emergency Ward

What Is Burnout?

Burnout is distinct from depression, which influences every aspect of life and often involves persistent thoughts of hopelessness or worthlessness. Burnout typically involves limited manifestations to the work environment, although its impact can resonate into other areas.

Symptoms of Burnout

1. Exhaustion: Prolonged mental and physical depletion of your energy levels.

2. Depersonalization: Cynicism and lack of concern creep into relationships and communication.

3 Reduced Personal Achievement: Your work loses worth, and you may feel you are not up to standards, giving in to frustration and reduced originality.

These signs frequently coincide with physical signs (headaches, muscle pain, sleeplessness), emotional signs (self-doubt, loneliness, unhappiness), and behavioral signs (social withdrawal, outbursts of anger, abandonment of obligations).