Happiness is influenced by a complex interplay of various chemicals in our brain, particularly four key neurotransmitters, D.O.S.E or Dopamine, Oxytocin, Serotonin, and Endorphins. These chemicals, often referred to as "happiness chemicals," are responsible for creating feelings of joy, motivation, connection, and calm.

However, when there's a deficiency in any of these, it can significantly affect our mood, energy, and overall well-being. Let’s dive into what these four neurotransmitters are, how their deficiency impacts us, and how we can boost their levels naturally.

Dopamine: The Motivation and Reward Chemical

Dopamine is often called the "motivation molecule." It plays a major role in enabling motivation, learning, and the pleasure-reward system in the brain. When we accomplish something — whether it’s finishing a project, completing a workout, or achieving a goal — dopamine gives us that sense of satisfaction and determination to continue.

Deficiency Effects:

When dopamine levels are low, it can lead to procrastination, low self-esteem, lack of focus, and general fatigue. A person might feel anxious, hopeless, or experience mood swings because the brain isn’t getting the reward signals it needs.

Boosting Dopamine:

You can increase dopamine levels by setting and achieving small goals, exercising regularly, eating foods rich in L-Tyrosine (such as almonds, avocados, and eggs), and practicing mindfulness or meditation. Engaging in creative activities like writing or drawing also helps boost dopamine levels.

Oxytocin: The Bonding Chemical

Oxytocin is often referred to as the "love hormone" or "cuddle hormone" because it plays a major role in social bonding and trust. It’s released when we hug, touch, or engage in other forms of physical affection. Oxytocin fosters feelings of connection and emotional intimacy, making it essential for relationships, family bonding, and even team cooperation.

Deficiency Effects:

A lack of oxytocin can lead to feelings of loneliness, stress, anxiety, and difficulties in forming or maintaining relationships. Low oxytocin levels are associated with feelings of isolation and disconnection from others.

Boosting Oxytocin:

You can raise your oxytocin levels through physical touch, socialising, spending quality time with loved ones, and even engaging in activities like massage or listening to soothing music. Acts of kindness, such as helping others or volunteering, also help release oxytocin.

Serotonin: The Mood Stabiliser

Serotonin is responsible for feelings of well-being and contentment. It helps regulate mood, sleep, digestion, and even social behavior. People who have balanced serotonin levels often feel calm, confident, and emotionally stable. Serotonin is crucial in helping people feel valued and significant among their peers.

Deficiency Effects:

Low serotonin levels are linked to depression, low self-esteem, irritability, and mood swings. Individuals may feel overly sensitive to criticism, experience panic attacks, or struggle with social phobias when serotonin is deficient.

Boosting Serotonin:

You can boost serotonin by getting regular exercise, exposing yourself to sunlight, engaging in cold showers or massages, and practicing mindfulness. Simple activities like walking in nature, meditating, or doing yoga are also effective serotonin enhancers.

Endorphins: The Pain Reliever

Endorphins are the body’s natural painkillers. Released in response to stress, pain, or intense physical activity, they help alleviate discomfort and promote a sense of euphoria. Endorphins are what make you feel good after a workout or a hearty laugh, often referred to as the "runner's high."

Deficiency Effects:

Without enough endorphins, people may experience anxiety, depression, chronic pain, and insomnia. A deficiency in endorphins can make daily life feel overwhelming and physically draining.

Boosting Endorphins:

To boost endorphins, engage in laughter, exercise, and stretching activities. Eating spicy foods or dark chocolate can also stimulate endorphin production. Regular massage therapy and meditation are other ways to naturally elevate endorphin levels.

World Health Day is observed annually on April 7 to mark the founding day of the World Health Organization (WHO) in 1948 for public health worldwide.

The Day raises awareness about global health issues and highlights the importance of preventive care, healthy lifestyles, and equal access to healthcare for all.

On World Health Day 2026, the WHO urged people to renew their commitment to working together and supporting science as the twin engines driving better health.

“Science is one of humanity’s most powerful tools for protecting and improving health,” said Tedros Adhanom Ghebreyesus, Director-General of the World Health Organization.

“People in every country live longer and healthier lives on average today than their ancestors did, thanks to the power of science. Vaccines, penicillin, germ theory, MRI machines, and the mapping of the human genome are just some of the achievements that science has delivered that have saved lives and transformed health for billions of people.”

World Health Day 2026: History

World Health Day commemorates the formal establishment of the WHO in 1948. The creation of an independent, international health body was proposed by Brazil and China in 1945.

The WHO Constitution, signed in 1946 by 61 nations, officially came into force on April 7, 1948. In the last 78 years of its existence, the WHO has directed and coordinated the world’s response to health emergencies such as :

• Severe Acute Respiratory Syndrome (SARS)
• Ebola outbreak
• COVID-19 pandemic
• mPox

In addition, it has also led global efforts against communicable diseases (like malaria, HIV, polio) and works on non-communicable diseases (e.g., cancer, diabetes).

The WHO works towards universal health coverage, with a

• focus on primary health care
• improving access to essential medicines and health products
• training the health workforce and advising on labour policies
• improving monitoring, data, and information.

World Health Day 2026: Theme

World Health Day 2026 will be observed under the theme “Together for health. Stand with science.”

The theme highlights the role of the WHO in promoting public health, which has led to improvements in the global maternal mortality rate, falling by more than 40 percent since 2000, and a reduction of over 50 percent in deaths among children under five.

The global health body lauded the advances in technology and scientific knowledge and skills, due to which the once-life-threatening health challenges – such as elevated blood pressure, cancer diagnoses, or HIV infection – have turned into manageable health issues.

The WHO stated that science was behind every health progress, which led to improvements in global health and lives. This includes the development of

• anesthesia
• safer medicines and affordable vaccination
• screening technologies, such as electronic blood pressure monitors and mammography tools.

WHO and its partners generate and translate evidence across a wide range of health priorities, from infectious diseases and chronic conditions to mental health, nutrition , and environmental risks, supporting countries to deliver effective, equitable care.

Rebecca King Crews, wife of actor Terry Crews, has opened up about her diagnosis with Parkinson's disease, which was previously dismissed as mere anxiety.

Speaking on the TODAY show, she also revealed a newly-approved procedure that has helped manage her symptoms. After three years, she’s able to write.

"I feel good," King Crews said during the segment. "I’m able to write my name and my dates, and I’m able to write with my right hand for the first time in probably three years."

Parkinson's Dismissed As Anxiety

The symptoms came suddenly and progressed quickly. Rebecca revealed that her first set of symptoms appeared around 2012, which began with numbness in her left foot while working out. It then progressed to a limp.

Then her left arm wasn't swinging as much as her right during certain exercises. Another was experiencing tremors while applying lip gloss, putting on makeup, or brushing her teeth. However, her doctor just thought she was having anxiety, the Today report said.

After three years of confusing symptoms, a Parkinson's specialist in 2015 recognized that she had the condition.

US FDA-approved treatment for Parkinson’s

Also read: Japan Approves First-Ever Stem Cell Therapies For Parkinson’s And Heart Failure

In the hope of a miracle, Rebecca was praying on her knees beside her bed when her husband, Terry Crews, informed her of a US Food and Drug Administration (FDA) non-invasive surgical procedure for her symptoms.

Last month, she underwent the new procedure called a bilateral focused ultrasound. The 2025 approved procedure uses sound waves directed into the brain to eradicate the debilitating symptoms.

What Is Parkinson's Disease?

Parkinson's disease is a progressive, neurodegenerative movement disorder caused by the loss of dopamine-producing brain cells, primarily affecting people over 60. Apart from motor loss, the disease also causes cognitive decline, depression, anxiety, and swallowing problems.

The first symptom may be a barely noticeable tremor in just one hand or sometimes a foot or the jaw. Over time, swinging your arms may become difficult, and your speech may become soft or slurred. The disorder also causes stiffness, slowing of movement, and trouble with balance that raises the risk of falls.

Also read: Is Parkinson's Disease Infectious?

What Is A Focused Ultrasound For Parkinson's?

Focused ultrasound is a noninvasive, therapeutic technology with the potential to improve the quality of life and decrease the cost of care for patients with symptoms secondary to Parkinson’s disease.

This novel technology focuses on beams of ultrasonic energy to targets deep in the brain without damaging surrounding normal tissue.

During the procedure, doctors use a device called Exablate Neuro, developed by a company called Insightec, to deliver ultrasound waves to specific areas on both sides of the brain.

They're guided by magnetic resonance imaging (MRI) to target the areas thought to be involved in the movement symptoms in Parkinson's.

The procedure typically produces immediate results and can be a good option for people who can't or don't want to pursue deep-brain stimulation, according to the Michael J. Fox Foundation for Parkinson's Research.

A fall at home might look small, but for women older than 65, a broken hip can be a big and serious health problem. In real medical terms, this condition has a 20 to 30 percent chance of being deadly within the first year.

As people get older, their bones get weaker because of osteoporosis, which makes them more likely to break even from small falls. However, the bigger problem starts once the injury happens.

According to World Health organization (WHO), around 60 per cent of people living with osteoarthritis are women, yet awareness remains limited until symptoms begin to interfere with mobility and daily function.

Loss Of Muscles

Reports show that 70 per cent of women will get arthritis and osteoporosis. Most of them had no idea it was coming. HealthandMe spoke to experts to understand the reasons behind the trend.

Dr Gurdeep Avinash Ratra, Consultant - Orthopedics and Joint Replacement, Manipal Hospitals, Gurugram said that the development of these disorders is gradual and closely tied to physiological changes.

“After the age of 30, there is a steady decline in muscle mass, accompanied by a more rapid reduction in strength and power. With menopause, the significant fall in estrogen levels removes natural protection for bone density and joint health. Over time, this leads to increased bone fragility, reduced muscular support, and stress on joints, thereby elevating the risk of fractures and chronic joint conditions,” Ratra told HealthandMe.

Health Coach Prashant Desai in a post on social media platform X, noted that after the age of 30:

• muscle mass starts declining by 1 per cent every year.
• muscle strength declines three times faster.
• muscle power declines eight times faster.

Treatment

Experts said a hip fracture needs to be treated right away as a serious medical problem that requires care from many different medical specialists, not just a doctor who focuses on bones.

Dr Rajesh Kumar Verma, Director – Orthopedics & Joint Replacement, Max Super Speciality Hospital, Vaishali explained that limited movement can cause blood clots, chest infections, pressure sores, and loss of muscle quickly. Many patients also face a quick drop in their ability to take care of themselves, which can impact both their body and mind.

Also read: Suffering From Mid-back Pain? Doctors Say It May Be Spinal TB

“Delayed treatment further increases risk. Early surgery and prompt recovery treatment help increase the chances of surviving and recovering better,” Verma told HealthandMe.

How to Prevent

• Maintaining a healthy waist circumference as an early indicator of metabolic health.
• Engaging in regular strength training to preserve bone density and muscle mass.
• Ensuring adequate protein intake to support muscle maintenance.
• Incorporating sufficient calcium and Vitamin D into the diet.
• Remaining physically active, with exercise beyond low impact activities alone.
• Get medical help right away if you fall or think you might have a broken bone.
• Have surgery as soon as your doctor suggests it, because it can help you recover better.
• Begin physiotherapy as soon as possible after the surgery to help restore movement and avoid any serious issues.
• Make sure to eat well, paying special attention to getting enough protein, calcium, and vitamin D.
• Check for fall risks at home by looking at things like lighting, floor surfaces, and handrails.

What to avoid

• Do not wait to go to the hospital, even if the hip fracture pain feels okay.
• Avoid staying in bed for long because a hip fracture can lead to infections, pressure sores, and blood clots.
• Do not skip osteoporosis treatment for hip fractures because it is very important to stop broken bones from happening again.
• Avoid skipping follow-ups or rehabilitation sessions for hip fractures after the surgery.