Happiness is influenced by a complex interplay of various chemicals in our brain, particularly four key neurotransmitters, D.O.S.E or Dopamine, Oxytocin, Serotonin, and Endorphins. These chemicals, often referred to as "happiness chemicals," are responsible for creating feelings of joy, motivation, connection, and calm.

However, when there's a deficiency in any of these, it can significantly affect our mood, energy, and overall well-being. Let’s dive into what these four neurotransmitters are, how their deficiency impacts us, and how we can boost their levels naturally.

Dopamine: The Motivation and Reward Chemical

Dopamine is often called the "motivation molecule." It plays a major role in enabling motivation, learning, and the pleasure-reward system in the brain. When we accomplish something — whether it’s finishing a project, completing a workout, or achieving a goal — dopamine gives us that sense of satisfaction and determination to continue.

Deficiency Effects:

When dopamine levels are low, it can lead to procrastination, low self-esteem, lack of focus, and general fatigue. A person might feel anxious, hopeless, or experience mood swings because the brain isn’t getting the reward signals it needs.

Boosting Dopamine:

You can increase dopamine levels by setting and achieving small goals, exercising regularly, eating foods rich in L-Tyrosine (such as almonds, avocados, and eggs), and practicing mindfulness or meditation. Engaging in creative activities like writing or drawing also helps boost dopamine levels.

Oxytocin: The Bonding Chemical

Oxytocin is often referred to as the "love hormone" or "cuddle hormone" because it plays a major role in social bonding and trust. It’s released when we hug, touch, or engage in other forms of physical affection. Oxytocin fosters feelings of connection and emotional intimacy, making it essential for relationships, family bonding, and even team cooperation.

Deficiency Effects:

A lack of oxytocin can lead to feelings of loneliness, stress, anxiety, and difficulties in forming or maintaining relationships. Low oxytocin levels are associated with feelings of isolation and disconnection from others.

Boosting Oxytocin:

You can raise your oxytocin levels through physical touch, socialising, spending quality time with loved ones, and even engaging in activities like massage or listening to soothing music. Acts of kindness, such as helping others or volunteering, also help release oxytocin.

Serotonin: The Mood Stabiliser

Serotonin is responsible for feelings of well-being and contentment. It helps regulate mood, sleep, digestion, and even social behavior. People who have balanced serotonin levels often feel calm, confident, and emotionally stable. Serotonin is crucial in helping people feel valued and significant among their peers.

Deficiency Effects:

Low serotonin levels are linked to depression, low self-esteem, irritability, and mood swings. Individuals may feel overly sensitive to criticism, experience panic attacks, or struggle with social phobias when serotonin is deficient.

Boosting Serotonin:

You can boost serotonin by getting regular exercise, exposing yourself to sunlight, engaging in cold showers or massages, and practicing mindfulness. Simple activities like walking in nature, meditating, or doing yoga are also effective serotonin enhancers.

Endorphins: The Pain Reliever

Endorphins are the body’s natural painkillers. Released in response to stress, pain, or intense physical activity, they help alleviate discomfort and promote a sense of euphoria. Endorphins are what make you feel good after a workout or a hearty laugh, often referred to as the "runner's high."

Deficiency Effects:

Without enough endorphins, people may experience anxiety, depression, chronic pain, and insomnia. A deficiency in endorphins can make daily life feel overwhelming and physically draining.

Boosting Endorphins:

To boost endorphins, engage in laughter, exercise, and stretching activities. Eating spicy foods or dark chocolate can also stimulate endorphin production. Regular massage therapy and meditation are other ways to naturally elevate endorphin levels.

There are many patients with CKD and CKD touches more than just the kidneys. CKD also influences parts of the body and as kidney function falls changes in the body can affect the brain. This may raise the chance of memory problems trouble concentrating and other types of impairment. For people living with CKD, those whose disease is advanced protecting cognitive health can become an important part of overall care.

CKD can arise from causes with diabetes as a leading one. In some groups diabetes accounts for than half of CKD cases. When diabetes meets CKD, the risk of vascular disease rises. This disease builds fatty deposits inside blood vessels. If those vessels feed the brain blood flow can drop. Reduced brain blood flow can lead to problems and raise the risk of dementia.

Waste Build-Up And Electrolyte Changes May Affect Thinking

Another important factor is the build‑up of waste in the blood. Healthy kidneys waste and excess substances. When CKD lowers kidney function these substances linger. The lingering waste can disturb brain function. Symptoms may include trouble paying attention, slower thinking, confusion or memory problems.

Electrolyte disturbances can also play a role especially when CKD changes the balance of minerals in the body.

Hyponatremia or abnormally low levels of sodium in the blood is relatively common in people with CKD. It can disturb brain function.

Depending on severity and how fast it appears hyponatremia can cause confusion, difficulty concentrating, drowsiness and in cases more serious neurological symptoms.

Also read: Diabetes Linked To 55% Risk Of Kidney Disease, Heart Failure Or Death Within 10 Years: Study

How Dialysis And Treatment History Can Influence Cognitive Health

Treatment‑related factors may also be relevant for some patients.

In the past dialysis patients who received aluminium‑containing medicines, such as some antacids or phosphate‑binding preparations faced a risk of aluminium build‑up. High levels of aluminium were linked to problems, including cognitive impairment. Today dialysis practices and medicines have cut this risk dramatically so aluminium is now an issue rather than a common cause of cognitive problems in dialysis patients.

Why Early Recognition Of Cognitive Changes Matters

As CKD moves forward into advanced stages the risk of cognitive impairment grows. Many factors can act together: disease, metabolic and electrolyte changes, anaemia, inflammation, heart complications and the build‑up of toxins that healthy kidneys would normally flush away.

Not every person with CKD will develop dementia. Cognitive changes should not be brushed off as normal ageing. New problems, with memory, concentration orientation or daily tasks need to be talked about with a doctor.

Early recognition is important because some of these factors can be treated or reversed.

Keeping diabetes and blood pressure under control managing heart risk factors correcting electrolyte imbalances and getting kidney care all help protect both kidney and brain health.

Plastics are everywhere today. It is woven into our clothes, tucked into children's toys, used in food containers, and found in almost every household products. A new analysis has raised concerns about the chemicals used to make these products and the health hazards due to constant exposure.

According to an investigation reported by CNN, nearly 93% of known plastic chemicals used in everyday products were classified as posing a high risk to human health. The analysis looked at plastics used in food-contact materials, toys, clothing and textiles, household products, and hygiene and medical products.

The findings highlight how widespread exposure to hazardous chemicals can affect our health and how much remains unknown about their long-term effects.

Exposure To Plastic Chemicals

A researcher at Environmental Justice Foundation, Naima Fenderl’s Poison Plastics: How Chemicals in Everyday Plastics are Harming Your Health released recently and revealed astounding facts about plastic chemicals.

She said, “We looked at what these plastic chemicals can do to the body along with exposure levels to calculate overall health risk.” The analysis found that:

• Nearly 92% of chemicals in food-related plastics were considered high risk.
• Almost 89% of children's toys contained high-risk plastics.
• Around 93% of textiles and clothing involved dangerous chemicals.
• More than 92% of common household products contained high-risk chemicals.
• Nearly 93% of hygiene and medical plastics contained potentially dangerous chemicals.

The chemicals are not necessarily the plastic itself. Many are additives that are used to make plastics flexible, durable, heat-resistant, or less likely to catch fire.

Also read: Botox And Fillers: UK Watchdog Says Clinics Should Check Mental Health Before Injecting

Health Problems Caused By Plastic Chemicals

Some plastic chemicals have been linked to cancer, genetic changes and problems affecting the hormonal, reproductive and organ systems. Among the chemicals of concern are bisphenols, phthalates, and PFAS, which can be used in different plastic products.

Some of these chemicals can interfere with the body's endocrine system, which controls hormones involved in metabolism, reproduction, growth, and development.

The concern is important for children and during pregnancy because hormonal systems and organ development may be more vulnerable to certain chemical exposures.

The report also highlighted the challenge of lack of sufficient data to certainly assess health risks posed by these plastic chemicals. Almost 80% of the 3,552 chemicals in plastics people often use everyday lacked sufficient data to understand health risks.

“We simply do not have a clue what harm those chemicals might be causing us and our kids,” Dr. Philip Landrigan, director of the Global Observatory on Planetary Health and the Program for Global Public Health and the Common Good at Boston College told CNN.

He added, “We don’t even know the names or composition of a lot of the chemicals that are in consumer products — the chemical industry presumably has that information, but it’s not publicly available.”

Also read: World Environment Day 2025: Everyday Habits That Are Harming The Earth And Your Health

Microplastics Are Part Of The Problem Too

Chemical exposure is only one part of the plastic problem. Tiny plastic particles, known as microplastics, and even smaller nanoplastics, can also enter our bodies through food and water.

University of Columbia released an analysis of plastic bottled water based on a laser-based highly sensitive imaging technique. It found an average of around 240,000 plastic particles per litre, with most nanoplastics.

These particles can come from the bottle, the cap, manufacturing, and handling. Opening and closing the bottle repeatedly can also create friction between the cap and bottle neck, releasing tiny plastic fragments.

Larger particles are generally expected to pass through the digestive system. But nanoplastics are small enough to cross biological barriers.

Research has found that plastic particles can reach the circulatory system and other tissues, but scientists still do not know exactly which particles cross these barriers most easily, how much accumulates in the body or what level of exposure causes harm.

What Is The Solution?

Quitting using plastic entirely is not practical for most people. Instead, reducing avoidable exposure could be a sensible approach.

Avoid heating food in plastic containers, particularly when the container is not designed for high temperatures. Using glass or stainless steel for hot food and drinks can also reduce reliance on plastic food-contact materials.

Filtration or boiling of drinking water may help reduce some microplastics. But doctors believe that heat may only alter some plastic particles, not destroy them completely.

It's hard to find anyone these days whose day doesn't involve a phone, a laptop, or a tablet at some point, often for several hours. We work off them, study off them, unwind by scrolling or watching something on them. All that convenience comes at a cost, though, and it isn't limited to the eyes. Sleep, hearing, posture, general well-being- screens end up touching all of it.

Long Screen Hours Can Strain Your Eyes

Eye strain is usually the first thing people notice. Stare at a screen close-up for long stretches, and the eyes start to dry out, burn, blur, and headaches creep in along with trouble focusing. Part of the problem is that we simply blink less when we're absorbed in something on a screen, which makes the dryness worse.

A few small adjustments help, keeping the screen at a reasonable distance, not having the brightness too high, and something I often recommend to patients: the 20-20-20 rule. Every 20 minutes, look at something roughly 20 feet away for 20 seconds. It sounds minor, but it eases the strain.

Also read: Salt Stomping Before Bed: Does This Viral TikTok Sleep Hack Actually Work?

Long Hours With Earphones Can Affect Hearing

Screens affect more than eyesight. Long hours spent wearing earphones, particularly at high volumes, can gradually affect hearing. The risk depends on both the volume and the duration of exposure.

Keeping the volume at a comfortable level and taking regular breaks from earphones is a simple enough habit to build. Persistent ringing in the ears, muffled hearing or difficulty following conversations should not be dismissed as fatigue and should be evaluated by a doctor.

Screen Use Can Disrupt Sleep

Sleep is one of the most overlooked casualties of excessive screen use. Phones and laptops used late at night keep the brain stimulated when the body should be winding down for rest. Bright light from screens, along with constant notifications, social media and work-related activity, makes it harder to unwind and fall asleep. Poor sleep, in turn, contributes to daytime fatigue, reduced concentration and irritability.

None of this means giving up technology altogether. It comes down to building healthier digital habits, avoiding screens close to bedtime, keeping phones away from the bed, taking regular movement breaks during work, and spending some time outdoors. For people working at computers for extended periods, maintaining good posture and changing position regularly matters just as much.

Also read: Weekend Workouts: Why Sudden Intense Exercise May Put Stress on Your Heart

There Is No Single ‘Safe’ Number Of Screen Hours

Clinical care today increasingly looks beyond treating disease to identifying everyday lifestyle factors that contribute to long-term health problems, and screen exposure is a good example of this. There isn't a single number of hours that is automatically harmful for every adult; the impact depends on what the screen is being used for, the intensity and duration of exposure, and whether it is interfering with sleep, physical activity or daily functioning.

Being screen-smart, rather than screen-free, is really the aim. Regular breaks, sensible volume levels, better sleep routines and more movement can go a long way in protecting the eyes, hearing and overall health, while still letting technology remain a useful part of modern life.

If symptoms such as persistent eye discomfort, hearing changes, recurrent headaches or ongoing sleep difficulties continue despite cutting down on screen time, it's worth seeking professional medical advice rather than relying on lifestyle adjustments alone.