Happiness is influenced by a complex interplay of various chemicals in our brain, particularly four key neurotransmitters, D.O.S.E or Dopamine, Oxytocin, Serotonin, and Endorphins. These chemicals, often referred to as "happiness chemicals," are responsible for creating feelings of joy, motivation, connection, and calm.

However, when there's a deficiency in any of these, it can significantly affect our mood, energy, and overall well-being. Let’s dive into what these four neurotransmitters are, how their deficiency impacts us, and how we can boost their levels naturally.

Dopamine: The Motivation and Reward Chemical

Dopamine is often called the "motivation molecule." It plays a major role in enabling motivation, learning, and the pleasure-reward system in the brain. When we accomplish something — whether it’s finishing a project, completing a workout, or achieving a goal — dopamine gives us that sense of satisfaction and determination to continue.

Deficiency Effects:

When dopamine levels are low, it can lead to procrastination, low self-esteem, lack of focus, and general fatigue. A person might feel anxious, hopeless, or experience mood swings because the brain isn’t getting the reward signals it needs.

Boosting Dopamine:

You can increase dopamine levels by setting and achieving small goals, exercising regularly, eating foods rich in L-Tyrosine (such as almonds, avocados, and eggs), and practicing mindfulness or meditation. Engaging in creative activities like writing or drawing also helps boost dopamine levels.

Oxytocin: The Bonding Chemical

Oxytocin is often referred to as the "love hormone" or "cuddle hormone" because it plays a major role in social bonding and trust. It’s released when we hug, touch, or engage in other forms of physical affection. Oxytocin fosters feelings of connection and emotional intimacy, making it essential for relationships, family bonding, and even team cooperation.

Deficiency Effects:

A lack of oxytocin can lead to feelings of loneliness, stress, anxiety, and difficulties in forming or maintaining relationships. Low oxytocin levels are associated with feelings of isolation and disconnection from others.

Boosting Oxytocin:

You can raise your oxytocin levels through physical touch, socialising, spending quality time with loved ones, and even engaging in activities like massage or listening to soothing music. Acts of kindness, such as helping others or volunteering, also help release oxytocin.

Serotonin: The Mood Stabiliser

Serotonin is responsible for feelings of well-being and contentment. It helps regulate mood, sleep, digestion, and even social behavior. People who have balanced serotonin levels often feel calm, confident, and emotionally stable. Serotonin is crucial in helping people feel valued and significant among their peers.

Deficiency Effects:

Low serotonin levels are linked to depression, low self-esteem, irritability, and mood swings. Individuals may feel overly sensitive to criticism, experience panic attacks, or struggle with social phobias when serotonin is deficient.

Boosting Serotonin:

You can boost serotonin by getting regular exercise, exposing yourself to sunlight, engaging in cold showers or massages, and practicing mindfulness. Simple activities like walking in nature, meditating, or doing yoga are also effective serotonin enhancers.

Endorphins: The Pain Reliever

Endorphins are the body’s natural painkillers. Released in response to stress, pain, or intense physical activity, they help alleviate discomfort and promote a sense of euphoria. Endorphins are what make you feel good after a workout or a hearty laugh, often referred to as the "runner's high."

Deficiency Effects:

Without enough endorphins, people may experience anxiety, depression, chronic pain, and insomnia. A deficiency in endorphins can make daily life feel overwhelming and physically draining.

Boosting Endorphins:

To boost endorphins, engage in laughter, exercise, and stretching activities. Eating spicy foods or dark chocolate can also stimulate endorphin production. Regular massage therapy and meditation are other ways to naturally elevate endorphin levels.

Naturopath and health educator Barbara O'Neill believes many of the foundations of good health are simple, inexpensive, and often overlooked.

In an interview with HealthandMe, she spoke about her journey into natural healing. Barbara said her interest began when she was looking for alternatives to repeated medication use for her children.

"I was pulled towards natural healing because I didn't want to give my children drugs," she said, recalling how her first child underwent four courses of antibiotics within six weeks.

That experience prompted her to explore other ways of managing common health issues such as earaches and discomfort.

On Ayurveda And Traditional Healing

Barbara said she sees similarities between her philosophy of health and Ayurveda. "I believe that there's a lot of similarities between what I believe," said the 72-year-old, adding that she supports approaches that work and do not cause harm.

While acknowledging that medicines can save lives in emergencies, she argued that long-term healing depends on creating the right conditions for the body.

"Yes, in a crisis, a drug may save a life, but drugs can't heal us. That's why it's time to go back to the old ways," she said.

According to Barbara, understanding how the body functions is key to understanding healing.

"When you understand how they function, then you begin to understand what they need. And if you give the body the right conditions, the healing will accelerate," she told HealthandMe.

The Healthy Habits

Barbara said that sleep, hydration, exercise, and natural foods are key to better health. She also called out modern lifestyles, which often encourage people to stay awake too late, particularly because of technology; and recommended getting enough sleep.

"Start going to bed earlier and aiming for eight hours sleep a night," she said.

Barbara also emphasized daily movement, whether through running, walking, push-ups, squats, or stretching.

"Every day, I make a point of moving my body," she said.

Why Barbara O'Neill Doesn't Take Supplements

At a time when supplements have become a multi-billion-dollar industry, Barbara revealed that she does not take any supplements herself.

"I take no supplements," she said, noting that she advocates focusing on fundamental health habits.

"What should be there instead is exercise every day, eating food in its natural state, drinking adequate water, and going to bed early," she said.

While she is not opposed to supplements, she believes they are often unnecessary.

"There are times where they may be necessary, but most of the time we don't need them," she added.

Natural Food And Stress Management

Barbara also encouraged people to eat foods in their natural state and suggested a simple dietary habit for Indians.

"Eat dal every day," she said.

For stress management, she said both sleep and meditation are important. She described beginning each day with prayer, reflection, and quiet time.

Barbara said that the human body has an innate ability to heal when supported by healthy habits.

"I want people to remember that they live in a body that can heal. So please look after it," she told HealthandMe.

Many working women who are pregnant tend to dismiss signs such as headaches, swelling, or vision changes, thinking that they are common during pregnancy. However, these issues can be caused by preeclampsia, a serious condition that requires timely attention, especially among busy working women.

What is preeclampsia?

Dr Prachi Sarin Sethi, Senior Consultant – Obstetrician, Gynaecologist & Laparoscopic Surgeon, Motherhood Hospitals, Gurgaon, said, "Pregnancy comes with many physical changes, and it is common for women to experience discomfort such as swelling, fatigue, or headaches. However, sometimes these symptoms may point to something more serious, namely preeclampsia, a pregnancy-related condition that can affect both the mother and baby. Working women tend to ignore the signs of this condition and struggle in silence. Preeclampsia is a condition that usually develops after the 20th week of pregnancy. It is mainly characterised by high blood pressure and can affect organs such as the liver and kidneys. If not managed in time, it can lead to serious complications for both mother and baby."

What are the causes of preeclampsia?

The exact cause of preeclampsia is not known. Certain factors increase the risk, including:

1. High blood pressure before pregnancy
2. First pregnancy
3. Multiple pregnancies (twins or more)
4. Obesity or diabetes
5. High stress levels and lack of rest

What are the symptoms of preeclampsia?

Many symptoms of preeclampsia are mistaken for normal pregnancy changes. These include:

1. Persistent headaches
2. Swelling in the face, hands, or feet
3. Blurred vision or light sensitivity
4. Sudden weight gain
5. Pain in the upper abdomen

Consequences of untreated preeclampsia

Working women may ignore these signs due to work pressure, long hours, or frequent travel, assuming they are just tired or stressed. If left untreated, preeclampsia can lead to serious complications such as:

1. Preterm delivery
2. Low birth weight of the baby
3. Organ damage in the mother
4. Seizures (a severe condition called eclampsia)

Early detection and proper care can help manage the condition and reduce risks.

This is why working women miss the signs

In today’s fast-paced lifestyle, many women continue working through pregnancy without slowing down. Long working hours, stress, irregular meals, and lack of rest tend to worsen symptoms. Many women delay check-ups or ignore warning signs, thinking they are minor issues.

What can women do?

Report any signs and symptoms, such as headaches and vision changes, to a doctor. De-stress by practising yoga and meditation. Monitor blood pressure regularly, avoid overexertion, and maintain a balanced diet consisting of fresh fruits, vegetables, whole grains, and pulses. Avoid junk, oily, and canned foods. It is also necessary to stay hydrated, attend regular health check-ups, and follow-up appointments.

Osteoarthritis (OA), long considered a “wear-and-tear” disease of old age, is increasingly being diagnosed in people as young as 30, according to new research.

The review by researchers at Indraprastha Apollo Hospitals suggests OA should be viewed as a heterogeneous syndrome rather than a single disease. The condition is driven by a combination of biological, biomechanical, metabolic, genetic, and molecular factors, but in youth obesity and poor lifestyle is surging the cases.

“Osteoarthritis is no longer confined to the elderly — we are now seeing patients as young as 30, often driven by obesity and sedentary lifestyles. This research makes clear that osteoarthritis is not a single disease but a spectrum of conditions,” said Dr. (Prof.) Raju Vaishya, Senior Consultant Orthopaedic and Joint Replacement Surgeon, Indraprastha Apollo Hospitals.

Noting that a one-size-fits-all approach may not help, the expert stressed the need for personalized treatment that recognizes the specific phenotype in each patient.

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Six Disease Subtypes Identified

The review, published in International Orthopaedics, identifies six disease subtypes, including inflammatory, metabolic, and pain-sensitization variants. Researchers recommend MRI-based tools and biomarker panels to guide treatment decisions.

Emerging technologies such as AI-assisted MRI scoring and PET-MRI with 18F-NaF may also enable earlier detection and better patient classification, although wider clinical adoption will require standardized protocols and large-scale validation studies.

Osteoarthritis Burden Rising Worldwide

More than 500 million people worldwide live with osteoarthritis, accounting for 7.6 per cent of the global population. According to Global Burden of Disease estimates, prevalence has increased by 132 per cent over the past 30 years and is projected to rise by another 60 per cent by 2050.

Women, people with obesity, and those with previous joint injuries are disproportionately affected.

What Is Osteoarthritis And Its Symptoms?

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Osteoarthritis occurs when the cartilage that cushions the ends of bones gradually wears down, causing joints to become stiff, painful, and less mobile.

The disease commonly affects the knees, hips, and small joints of the hands, although it can occur in almost any joint.

Common symptoms include:

• Joint pain
• Joint stiffness
• Difficulty moving affected joints
• Swelling
• Joint tenderness
• A grating or crackling sensation during movement
• Pain and stiffness after periods of inactivity
• Enlarged or knobbly joints
• Reduced range of movement
• Muscle weakness or muscle loss

How To Prevent Osteoarthritis

Experts say maintaining a healthy weight, staying physically active, avoiding prolonged sedentary behaviour, and preventing joint injuries can help lower the risk of osteoarthritis.

One of the biggest challenges in osteoarthritis treatment is the “care gap.” Many patients are too young or not yet severe enough for surgery but may spend years relying on medications that relieve symptoms without addressing the underlying mechanics of joint stress.

Research suggest gait retraining — adjusting the way a person walks — could help bridge this gap. Unlike medication or surgery, gait retraining is non-invasive and may offer a sustainable long-term solution.

Currently, gait retraining often requires specialized tools such as motion-capture systems and pressure-sensitive treadmills. However, newer approaches, including smartphone-based video analysis and sensor-equipped “smart shoes,” are being developed to make the technique more accessible.

Experts caution against making major changes to walking patterns without professional guidance, as improper adjustments may place additional strain on other parts of the body.