Happiness is influenced by a complex interplay of various chemicals in our brain, particularly four key neurotransmitters, D.O.S.E or Dopamine, Oxytocin, Serotonin, and Endorphins. These chemicals, often referred to as "happiness chemicals," are responsible for creating feelings of joy, motivation, connection, and calm.

However, when there's a deficiency in any of these, it can significantly affect our mood, energy, and overall well-being. Let’s dive into what these four neurotransmitters are, how their deficiency impacts us, and how we can boost their levels naturally.

Dopamine: The Motivation and Reward Chemical

Dopamine is often called the "motivation molecule." It plays a major role in enabling motivation, learning, and the pleasure-reward system in the brain. When we accomplish something — whether it’s finishing a project, completing a workout, or achieving a goal — dopamine gives us that sense of satisfaction and determination to continue.

Deficiency Effects:

When dopamine levels are low, it can lead to procrastination, low self-esteem, lack of focus, and general fatigue. A person might feel anxious, hopeless, or experience mood swings because the brain isn’t getting the reward signals it needs.

Boosting Dopamine:

You can increase dopamine levels by setting and achieving small goals, exercising regularly, eating foods rich in L-Tyrosine (such as almonds, avocados, and eggs), and practicing mindfulness or meditation. Engaging in creative activities like writing or drawing also helps boost dopamine levels.

Oxytocin: The Bonding Chemical

Oxytocin is often referred to as the "love hormone" or "cuddle hormone" because it plays a major role in social bonding and trust. It’s released when we hug, touch, or engage in other forms of physical affection. Oxytocin fosters feelings of connection and emotional intimacy, making it essential for relationships, family bonding, and even team cooperation.

Deficiency Effects:

A lack of oxytocin can lead to feelings of loneliness, stress, anxiety, and difficulties in forming or maintaining relationships. Low oxytocin levels are associated with feelings of isolation and disconnection from others.

Boosting Oxytocin:

You can raise your oxytocin levels through physical touch, socialising, spending quality time with loved ones, and even engaging in activities like massage or listening to soothing music. Acts of kindness, such as helping others or volunteering, also help release oxytocin.

Serotonin: The Mood Stabiliser

Serotonin is responsible for feelings of well-being and contentment. It helps regulate mood, sleep, digestion, and even social behavior. People who have balanced serotonin levels often feel calm, confident, and emotionally stable. Serotonin is crucial in helping people feel valued and significant among their peers.

Deficiency Effects:

Low serotonin levels are linked to depression, low self-esteem, irritability, and mood swings. Individuals may feel overly sensitive to criticism, experience panic attacks, or struggle with social phobias when serotonin is deficient.

Boosting Serotonin:

You can boost serotonin by getting regular exercise, exposing yourself to sunlight, engaging in cold showers or massages, and practicing mindfulness. Simple activities like walking in nature, meditating, or doing yoga are also effective serotonin enhancers.

Endorphins: The Pain Reliever

Endorphins are the body’s natural painkillers. Released in response to stress, pain, or intense physical activity, they help alleviate discomfort and promote a sense of euphoria. Endorphins are what make you feel good after a workout or a hearty laugh, often referred to as the "runner's high."

Deficiency Effects:

Without enough endorphins, people may experience anxiety, depression, chronic pain, and insomnia. A deficiency in endorphins can make daily life feel overwhelming and physically draining.

Boosting Endorphins:

To boost endorphins, engage in laughter, exercise, and stretching activities. Eating spicy foods or dark chocolate can also stimulate endorphin production. Regular massage therapy and meditation are other ways to naturally elevate endorphin levels.

We know of the Japanese way of walking, and the Chinese way of losing weight by getting yourself enrolled in "Fat Prison", but did you know that there is a Korean Way of doing things. And no, this is not skincare. We are talking about the Korean way of brushing, using the 3-3-3 rule.

This method recommends brushing thrice a day, within three minutes of eating, and for at least three minutes of duration.

This is especially for when we eat sugary foods or snacks in between the meals. Korean cuisine uses a lot of spices, especially garlic. This is why, Koreans believe brushing their teeth is important so the smell does not linger.

In fact, many Koreans carry a toothbrush and toothpaste at work.

The Korean Way Of Brushing: A Study

A study conducted between 2012 and 2014 by the Division of Chronic Disease Surveillance, Cheongju, Korea, under the Korean Centers for Disease Control and Prevention and the Korean Ministry of Health and Welfare, Sejong, Korea, assessed the association between oral health and periodontal disease. The study used nationally representative data from the Korean National Health and Nutrition Examination Survey (KNHNES).

The study used a detailed, multi-stage survey method designed to fairly represent the non-institutionalized civilian population. Trained health workers visited participants in their homes and carried out standardized health examinations.

Initially, 23,626 people were considered for the KNHANES survey. The analysis focused on 18,382 adults aged 19 and above. After excluding participants with no data on periodontal health, the sample dropped to 15,754. The final analysis included 14,527 individuals with complete information. The study was approved by the Institutional Review Board of the Korean Centers for Disease Control and Prevention and followed the ethical principles outlined in the Helsinki Declaration.

Researchers recorded when participants brushed their teeth—before or after breakfast, lunch, dinner, after snacks, or before bedtime—and whether they used additional oral care products such as dental floss, mouthwash, interdental brushes, electric toothbrushes, tongue cleaners, or denture-specific tools. Daily brushing frequency was calculated based on how many times teeth were brushed each day. Information on tooth pain, past orthodontic treatment, and dental checkups within the past year was also collected.

The findings showed that people who brushed after lunch and before bedtime had lower rates of periodontal disease, while brushing after dinner was linked to fewer severe cases. Using additional oral care tools, especially dental floss and powered toothbrushes, was also associated with better periodontal health.

In many countries, it is a norm to brush your teeth at least twice a day. However, in Korea, the 3-3-3 brushing technique is more than a norm.

Is Brushing Three Times A Day Too Much?

While brushing is a great habit, one may be worried if brushing too much can lead to enamel erosion. However, brushing three times a day may not be excessive, as the American Dental Association recommends brushing teeth after every meal as ideal for optimal oral health.

The reason is that bacteria and food particles can accumulate on our teeth within minutes of eating or drinking. If left uncleaned, this could also lead to plaque buildup and tooth decay. This could lead to cavities and other dental issues.

People troubled by increasing forgetfulness are being advised to have their vitamin levels checked, as a shortage of one essential nutrient can cause symptoms that closely resemble dementia. According to the NHS, a deficiency in a key vitamin may lead to neurological issues that affect the nervous system, including problems with memory.

As per Mirror, Dr Eric Berg, DC, has also drawn attention to what he calls the “leading vitamin deficiency that mimics dementia,” identifying vitamin B12 as a major concern. Adequate levels of this nutrient are vital because it helps form red blood cells that carry oxygen through the body, supports DNA production and regulation, and converts food into usable energy.

Dr Berg, well known for promoting healthy ketosis and intermittent fasting, is the author of the bestselling book The Healthy Keto Plan and runs Dr Berg Nutritionals. He has since moved away from clinical practice to focus on sharing health information through online platforms.

Why Is Vitamin B12 Important?

Vitamin B12 is essential for the healthy functioning of the central nervous system and plays a key role in maintaining clear thinking and memory. When levels drop, people may experience weakness, numbness, difficulty walking, nausea, unintended weight loss, irritability, extreme tiredness, and a fast or irregular heartbeat.

Bones, hair, skin, and nails may also suffer. Dr Berg explains: “Vitamin B12 is essential for normal brain function. Without it, symptoms similar to dementia can develop. This vitamin is mainly found in animal-based foods, although some microbes can produce it. Low intake of animal products is the most common reason for vitamin B12 deficiency.”

Research suggests that low B12 levels can impair nerve function and may contribute to conditions such as dementia, peripheral neuropathy, or subacute combined degeneration. A deficiency can also interfere with DNA synthesis and cause homocysteine levels to rise.

What Does The NHS Say?

On its official website, the NHS states: “Most cases of vitamin B12 or folate deficiency can be treated easily and effectively, so complications are uncommon. However, complications may sometimes occur, particularly if the deficiency has been present for a long time. If neurological problems develop, they can occasionally be permanent.”

The NHS explains that a lack of vitamin B12 may lead to neurological symptoms such as:

• vision problems
• memory loss
• pins and needles
• loss of physical coordination (ataxia), which can affect speech or walking
• damage to parts of the nervous system (peripheral neuropathy), especially in the legs

A study published in 2020 found a “clear association between low vitamin B12 levels and progressive cognitive impairment.” Researchers added that more large-scale studies are needed to confirm these findings and to see whether correcting the deficiency can slow cognitive decline.

More than one in ten older adults are estimated to have low vitamin B12 levels. In addition to memory problems, a deficiency may cause other neurological and psychological symptoms, including:

• confusion
• difficulty with thinking and reasoning
• tingling or numbness in the hands and feet
• poor balance and coordination
• fatigue
• weakness
• vision disturbances
• peripheral neuropathy affecting the nervous system
• depression, anxiety, paranoia, and delusions
• incontinence
• loss of taste and smell

Can A Vitamin B12 Deficiency Be Treated?

If a vitamin B12 deficiency is diagnosed, treatment usually involves high-dose supplementation, either through injections or oral supplements. GPs may arrange regular blood tests to monitor B12 levels over time.

As per The Mirror, the longer the deficiency goes untreated, the higher the risk of permanent damage. That said, it is often reversible, with many people noticing marked improvement within three to six months. Other signs of vitamin B12 deficiency may include:

• numbness, tingling, and pins and needles in the arms and legs
• pale skin
• unsteady walking or balance problems
• a rapid heartbeat
• shortness of breath
• a swollen tongue

“As we get older, HCL levels naturally decline. They can also drop if you take antacids or medications like Metformin. Interestingly, acid reflux can actually be a sign of low HCL, and antacids may worsen the problem. Betaine hydrochloride is one way to support normal stomach acidity.”

What Else Is Worth Being Aware Of?

Deficiencies in other nutrients may also cause symptoms that resemble dementia. Dr Berg highlights vitamin B1, which is often linked to high sugar and carbohydrate intake. Zinc deficiency, sometimes related to phytic acid found in grains, and low vitamin D levels due to limited sun exposure, may also play a role. “Nutrient deficiencies can shrink the hippocampus, which is linked to Alzheimer’s disease,” Dr Berg said.

The NHS has released fresh guidance on how to manage flu symptoms, setting out four simple steps that could help people recover faster. Influenza, commonly known as flu, is a highly contagious viral illness that affects the respiratory system, including the nose, throat, and lungs. It is marked by a sudden onset of fever, muscle aches, headaches, a persistent dry cough, and extreme tiredness, making it far more serious than the common cold.

Recent data from NHS England shows that in the first week of January, an average of 2,924 hospital beds across England were taken up by patients with flu. This figure reflects a nine per cent increase compared with the previous week.

With flu cases continuing to climb, the NHS has shared several important steps that people can follow to help support a quicker recovery.

NHS Shares Four Steps To Tackle Flu Symptoms 2026

In a recent update, NHS England warned that social gatherings during Christmas and New Year may have led to a resurgence of winter illnesses. NHS national medical director Professor Meghana Pandit said: “It is clear that the pressure on the NHS this winter is far from easing, with hospitals once again seeing a rise in patients admitted with flu and other respiratory viruses last week.

“The colder weather is also bringing more vulnerable patients to A&E with breathing difficulties, along with an increase in injuries caused by slips and falls in icy conditions, making this an exceptionally demanding period.”

According to the Mirror, she added: “Staff continue to work extremely hard, with teams across the country doing everything possible to ensure patients receive the care they need. It remains important for people to seek care as usual, and there are still many opportunities to get vaccinated and protect yourself against flu.”

Flu Symptoms 2026

The NHS says flu symptoms tend to appear suddenly and may include:

• A high temperature that comes on quickly
• Aches and pains throughout the body
• Feeling very tired or exhausted
• A dry, persistent cough
• A sore throat
• Headaches
• Trouble sleeping
• Loss of appetite
• Diarrhoea or stomach pain
• Feeling sick or being sick

Children may experience similar symptoms, but they can also have earaches and may appear more tired or less active than usual.

Flu Symptoms 2026: NHS Advice

The NHS states: “If you have flu, there are steps you can take to help yourself recover more quickly.”

• Rest and get plenty of sleep
• Keep yourself warm
• Use paracetamol or ibuprofen to reduce fever and ease aches and pains
• Drink plenty of fluids to prevent dehydration, aiming for urine that is pale yellow or clear

Flu Symptoms 2026: When To Seek Help?

You should contact NHS 111 or arrange an urgent GP appointment if you or your child have flu symptoms and:

• You are concerned about your baby’s or child’s condition
• You are aged 65 or over
• You are pregnant
• You have a long-term health condition, such as diabetes or a problem affecting the heart, lungs, kidneys, brain, or nerves
• You have a weakened immune system, for example due to chemotherapy or HIV
• Your symptoms have not improved after seven days
• You develop sudden chest pain
• You have trouble breathing
• You begin coughing up large amounts of blood