Happiness is influenced by a complex interplay of various chemicals in our brain, particularly four key neurotransmitters, D.O.S.E or Dopamine, Oxytocin, Serotonin, and Endorphins. These chemicals, often referred to as "happiness chemicals," are responsible for creating feelings of joy, motivation, connection, and calm.

However, when there's a deficiency in any of these, it can significantly affect our mood, energy, and overall well-being. Let’s dive into what these four neurotransmitters are, how their deficiency impacts us, and how we can boost their levels naturally.

Dopamine: The Motivation and Reward Chemical

Dopamine is often called the "motivation molecule." It plays a major role in enabling motivation, learning, and the pleasure-reward system in the brain. When we accomplish something — whether it’s finishing a project, completing a workout, or achieving a goal — dopamine gives us that sense of satisfaction and determination to continue.

Deficiency Effects:

When dopamine levels are low, it can lead to procrastination, low self-esteem, lack of focus, and general fatigue. A person might feel anxious, hopeless, or experience mood swings because the brain isn’t getting the reward signals it needs.

Boosting Dopamine:

You can increase dopamine levels by setting and achieving small goals, exercising regularly, eating foods rich in L-Tyrosine (such as almonds, avocados, and eggs), and practicing mindfulness or meditation. Engaging in creative activities like writing or drawing also helps boost dopamine levels.

Oxytocin: The Bonding Chemical

Oxytocin is often referred to as the "love hormone" or "cuddle hormone" because it plays a major role in social bonding and trust. It’s released when we hug, touch, or engage in other forms of physical affection. Oxytocin fosters feelings of connection and emotional intimacy, making it essential for relationships, family bonding, and even team cooperation.

Deficiency Effects:

A lack of oxytocin can lead to feelings of loneliness, stress, anxiety, and difficulties in forming or maintaining relationships. Low oxytocin levels are associated with feelings of isolation and disconnection from others.

Boosting Oxytocin:

You can raise your oxytocin levels through physical touch, socialising, spending quality time with loved ones, and even engaging in activities like massage or listening to soothing music. Acts of kindness, such as helping others or volunteering, also help release oxytocin.

Serotonin: The Mood Stabiliser

Serotonin is responsible for feelings of well-being and contentment. It helps regulate mood, sleep, digestion, and even social behavior. People who have balanced serotonin levels often feel calm, confident, and emotionally stable. Serotonin is crucial in helping people feel valued and significant among their peers.

Deficiency Effects:

Low serotonin levels are linked to depression, low self-esteem, irritability, and mood swings. Individuals may feel overly sensitive to criticism, experience panic attacks, or struggle with social phobias when serotonin is deficient.

Boosting Serotonin:

You can boost serotonin by getting regular exercise, exposing yourself to sunlight, engaging in cold showers or massages, and practicing mindfulness. Simple activities like walking in nature, meditating, or doing yoga are also effective serotonin enhancers.

Endorphins: The Pain Reliever

Endorphins are the body’s natural painkillers. Released in response to stress, pain, or intense physical activity, they help alleviate discomfort and promote a sense of euphoria. Endorphins are what make you feel good after a workout or a hearty laugh, often referred to as the "runner's high."

Deficiency Effects:

Without enough endorphins, people may experience anxiety, depression, chronic pain, and insomnia. A deficiency in endorphins can make daily life feel overwhelming and physically draining.

Boosting Endorphins:

To boost endorphins, engage in laughter, exercise, and stretching activities. Eating spicy foods or dark chocolate can also stimulate endorphin production. Regular massage therapy and meditation are other ways to naturally elevate endorphin levels.

Work stress could make you gay, said a Malaysian minister Zulkifli Hasan, as continued government intervention of what is described as 'sexually deviant behavior' has pressured the country's LGBTQ community. This happened two weeks after religious authorities and police acted on complaints from a sultan and Islamist politicians that a camping retreat was promoting the LGBTQ lifestyle, reported South China Morning Post.

Religious Affairs Minister Hasan on Tuesday said that work stress could be among many other factors that is pushing people into sexual orientations other than heterosexuality. “Societal influence, sexual experiences, work stress and other personal factors come under this category [of possible causes],” Zulkifli said in a written parliamentary reply to a question by Siti Zailah Mohd Yusoff, a lawmaker with the opposition Islamist party PAS.

He cited a 2017 study by Sulaiman et.al., that said such elements "can contribute to the increase in LGBT acts".

His comments have attracted a lot of backlash, with many people on social media mocking him. A social media user Muaz Zam said, "By this logic, I am genuinely shocked my entire office isn't gay by now". Another one read: "In other words: they never work hard in the parliament."

However, these claims are not scientifically back. Work related stress can impact a person, but cannot change their sexuality. It can, however, cause health effects. What it does not do is change one's sexuality and this is why one should know the difference about gender, sex and sexual orientation or sexuality.

'Work Stress Makes You Gay': The Difference Between Gender vs Sex

While these both terms are often used interchangeably in official forms, there is a difference between the two.

As per the Council of Europe, gender is an area that cuts across thinking about society, law, politics, and culture.

Read: Trump Administration Deadnames Transgender Former HHS Officer Rachel Levine in Official Portrait

Definition Of Gender vs Sex by WHO

The World Health Organization notes that sex refers to: "the different biological and physiological characteristics of males and females, such as reproductive organs, chromosomes, hormones, etc.”

Whereas, gender refers to: "the socially constructed characteristics of women and men – such as norms, roles and relationships of and between groups of women and men. It varies from society to society and can be changed. The concept of gender includes five important elements: relational, hierarchical, historical, contextual and institutional. While most people are born either male or female, they are taught appropriate norms and behaviours – including how they should interact with others of the same or opposite sex within households, communities and work places. When individuals or groups do not “fit” established gender norms they often face stigma, discriminatory practices or social exclusion – all of which adversely affect health."

Definition Of Gender vs Sex by The European Institute For Gender Equality

“Sex refers to the biological and physiological characteristics that define humans as female or male. These sets of biological characteristics are not mutually exclusive, as there are individuals who possess both, but these characteristics tend to differentiate humans as females or males.”

“Gender refers to the social attributes and opportunities associated with being female and male and to the relationships between women and men and girls and boys, as well as to the relations between women and those between men. These attributes, opportunities and relationships are socially constructed and are learned through socialisation processes. They are context- and time-specific, and changeable. Gender determines what is expected, allowed and valued in a woman or a man in a given context. In most societies, there are differences and inequalities between women and men in responsibilities assigned, activities undertaken, access to and control over resources, as well as decision-making opportunities. Gender is part of the broader sociocultural context. Other important criteria for sociocultural analysis include class, race, poverty level, ethnic group and age.”

The main difference is that gender is a social construct, whereas sex is the biologically labelled term based on organs and hormones.

Read More: Trump's Top Health Nominee Wants ‘Corrective Care’ For Trans People

What Is Sexuality?

As per the American Psychological Association (APA), sexuality is the capacity to derive pleasure from various forms of sexual activity and behavior. The Lanarkshire Sexual Health describes sexual orientation as a way to describe the feelings you have for someone you fancy or are attached to.

While sexuality can change overtime, it is not a choice. There is no evidence that sexual orientation can be forced to change through therapy.

Can Stress Impact Sexuality?

While stress can impact sexual function by reducing libido, causing fatigue, and triggering hormonal changes, it does not change one's sexual orientation. Jason Teoh, who writes on LGBTQ issues, project partner at NSW Department of Planning, Housing and Infrastructure, notes: "Sexual orientation is not caused by stress. It is not caused by trauma, influence or difficult life circumstances."

The WHO notes: sexual orientation is a natural, stable part of human identity shaped by biology, genetics, and early development. The WHO removed homosexuality from its disease classification in 1990. The American Psychiatric Association did the same in 1973.

Parkinson's disease is a progressive, neurodegenerative movement disorder caused by the loss of dopamine-producing brain cells, primarily affecting people over 60. Apart from motor loss, the disease also causes cognitive decline, depression, anxiety and swallowing problems.

The first symptom may be a barely noticeable tremor in just one hand or sometimes a foot or the jaw. Over time, swinging your arms may become difficult and your speech may become soft or slurred. The disorder also causes stiffness, slowing of movement and trouble with balance that raises the risk of falls.

However, before clear symptoms begin to appear, Neurologist Rachel Dolhun says certain signs may help identify the onset of the disease decades before it is diagnosed.

“It’s important to stress that not everyone who has these symptoms goes on to develop Parkinson’s,” said neurologist Rachel Dolhun. “But we know that in some people, these can be some of the earliest signs," she told The Washington Post.

Here is what you should look out for:

1. Loss Of Smell

Loss of smell, or hyposmia, is a common and early non-motor symptom of Parkinson's disease, affecting up to 90 percent of patients. This symptom can significantly impact quality of life by reducing the enjoyment of food and diminishing appetite.

While strongly linked to Parkinson's, smell loss can also stem from other causes, including sinus problems, COVID-19, or aging.

2. Acting Out Dreams

Acting out dreams, known as REM Sleep Behavior Disorder (RBD), involves physically enacting vivid, often unpleasant dreams through shouting, punching, or kicking during sleep.

This typically happens because the brainstem fails to temporarily paralyze muscles during REM sleep. It is a strong early warning sign of Parkinson's disease, often appearing years or decades before motor symptoms. About 50 percent of people with Parkinson's experience RBD.

READ MORE: Parkinson’s Patients May Soon Walk Better With This New Personalized Brain Therapy

3. Constipation

Constipation is a very common and significant non-motor symptom of Parkinson's disease that is caused by nerve changes slowing gut muscles and potentially exacerbated by low activity and dehydration.

Constipation can also be caused by Parkinson's medications such as anticholinergics, amantadine and other common drugs such as opioids, iron/calcium antacids.

4. Dizziness As You Stand

The autonomic nervous system fails to properly constrict blood vessels or increase heart rate upon standing, often due to a lack of norepinephrine. This causes the autonomic nervous system to fail in regulating blood pressure. Over time, this leads to Neurogenic Orthostatic Hypotension.

Beyond dizziness, symptoms include blurred vision, weakness, fatigue, cognitive "fog," and "coat hanger pain" (pain in the neck/shoulders). Often times, patients experience dizziness in the morning or immediately after meals.

Diagnosing Parkinson’s disease is mostly a clinical process, meaning it relies heavily on a healthcare provider examining your symptoms, asking questions and reviewing your medical history. Various imaging and diagnostic tests used to detect disease includes CT scan, PET scan, MRI scan and genetic testing.

Beyond icy roads and fogged-up car windscreens, the coldest season can also bring on a painful condition that leaves the skin covered in red, itchy patches. Doctors have issued a warning about this lesser-known illness, which tends to worsen in low temperatures.

The condition, known as cold urticaria, affects around one in 2,000 people. It causes swelling and itching of the skin when it comes into contact with cold air, cold water, or even air conditioning. Red welts or hives can appear within minutes, and the discomfort may last for as long as two hours.

What Is Cold Urticaria?

Cold urticaria is an uncommon condition in which the body reacts abnormally to cold temperatures. It typically causes rashes or hives after exposure to cold air, water, food, or drinks. In some cases, symptoms can be more serious. According to the Cleveland Clinic, the condition may sometimes be linked to an underlying blood cancer or an infectious illness.

Griet Voet, head of a dermatology clinic in Ghent, Belgium, as per Express UK, said the condition is often confused with common winter skin problems such as eczema. “This is not just dry skin caused by cold weather, it is a genuine allergic reaction to cold,” she explained. In more severe cases, large areas of the body may be affected, particularly after swimming in cold water or spending extended periods outdoors. This can lead to intense itching, facial flushing, and even headaches, stomach pain, or fainting. Sudden temperature shifts, such as moving from a warm indoor space into cold outdoor air, can also trigger symptoms. Drinking ice-cold beverages may cause swelling of the lips, mouth, or throat.

Cold Urticaria: What Are The Symptoms Of This Disease?

Symptoms of cold urticaria differ from person to person and can range from mild to severe. They may be limited to a small patch of skin or spread across the entire body.

The most common sign is a skin rash that appears after contact with something cold. The rash usually develops once the exposure ends, as the skin begins to warm up.

The rash may include:

• Hives, bumps, or raised welts
• Itching
• Redness
• Swelling

• Fatigue
• Fever
• Headache
• Joint pain

• Fainting
• Heart palpitations
• A severe allergic reaction known as anaphylaxis
• Shortness of breath or wheezing

How Is Cold Urticaria Diagnosed?

A medical professional can often diagnose cold urticaria using a simple test. An ice cube is placed on the skin, usually on the arm, for a few minutes and then removed. If a hive or rash appears several minutes later, the result is considered positive.

In cases of familial cold urticaria, diagnosis may involve exposure to cold air for a longer duration.

Doctors may also suggest blood tests to check for any underlying illness or infection that could be contributing to the condition.