Happiness is influenced by a complex interplay of various chemicals in our brain, particularly four key neurotransmitters, D.O.S.E or Dopamine, Oxytocin, Serotonin, and Endorphins. These chemicals, often referred to as "happiness chemicals," are responsible for creating feelings of joy, motivation, connection, and calm.

However, when there's a deficiency in any of these, it can significantly affect our mood, energy, and overall well-being. Let’s dive into what these four neurotransmitters are, how their deficiency impacts us, and how we can boost their levels naturally.

Dopamine: The Motivation and Reward Chemical

Dopamine is often called the "motivation molecule." It plays a major role in enabling motivation, learning, and the pleasure-reward system in the brain. When we accomplish something — whether it’s finishing a project, completing a workout, or achieving a goal — dopamine gives us that sense of satisfaction and determination to continue.

Deficiency Effects:

When dopamine levels are low, it can lead to procrastination, low self-esteem, lack of focus, and general fatigue. A person might feel anxious, hopeless, or experience mood swings because the brain isn’t getting the reward signals it needs.

Boosting Dopamine:

You can increase dopamine levels by setting and achieving small goals, exercising regularly, eating foods rich in L-Tyrosine (such as almonds, avocados, and eggs), and practicing mindfulness or meditation. Engaging in creative activities like writing or drawing also helps boost dopamine levels.

Oxytocin: The Bonding Chemical

Oxytocin is often referred to as the "love hormone" or "cuddle hormone" because it plays a major role in social bonding and trust. It’s released when we hug, touch, or engage in other forms of physical affection. Oxytocin fosters feelings of connection and emotional intimacy, making it essential for relationships, family bonding, and even team cooperation.

Deficiency Effects:

A lack of oxytocin can lead to feelings of loneliness, stress, anxiety, and difficulties in forming or maintaining relationships. Low oxytocin levels are associated with feelings of isolation and disconnection from others.

Boosting Oxytocin:

You can raise your oxytocin levels through physical touch, socialising, spending quality time with loved ones, and even engaging in activities like massage or listening to soothing music. Acts of kindness, such as helping others or volunteering, also help release oxytocin.

Serotonin: The Mood Stabiliser

Serotonin is responsible for feelings of well-being and contentment. It helps regulate mood, sleep, digestion, and even social behavior. People who have balanced serotonin levels often feel calm, confident, and emotionally stable. Serotonin is crucial in helping people feel valued and significant among their peers.

Deficiency Effects:

Low serotonin levels are linked to depression, low self-esteem, irritability, and mood swings. Individuals may feel overly sensitive to criticism, experience panic attacks, or struggle with social phobias when serotonin is deficient.

Boosting Serotonin:

You can boost serotonin by getting regular exercise, exposing yourself to sunlight, engaging in cold showers or massages, and practicing mindfulness. Simple activities like walking in nature, meditating, or doing yoga are also effective serotonin enhancers.

Endorphins: The Pain Reliever

Endorphins are the body’s natural painkillers. Released in response to stress, pain, or intense physical activity, they help alleviate discomfort and promote a sense of euphoria. Endorphins are what make you feel good after a workout or a hearty laugh, often referred to as the "runner's high."

Deficiency Effects:

Without enough endorphins, people may experience anxiety, depression, chronic pain, and insomnia. A deficiency in endorphins can make daily life feel overwhelming and physically draining.

Boosting Endorphins:

To boost endorphins, engage in laughter, exercise, and stretching activities. Eating spicy foods or dark chocolate can also stimulate endorphin production. Regular massage therapy and meditation are other ways to naturally elevate endorphin levels.

It often begins in the most ordinary way—someone sits down to enjoy a meal and suddenly feels a sharp swelling under the jaw or near the ear.

The pain intensifies with every bite, creating a strange pattern: eat, swell, hurt; stop eating, and the swelling slowly settles.

For many people, this puzzling cycle is caused by something surprisingly small—a salivary stone. Though typically no larger than a few millimeters, these tiny mineral deposits can cause significant discomfort and, if untreated, repeated infections. Fortunately, modern medicine has transformed how this condition is managed, replacing traditional gland removal surgery with a minimally invasive technique known as sialendoscopy.

A Salivary Stone

Saliva is something most of us rarely think about, yet it plays a vital role in everyday life. It helps us chew and swallow food, begins the process of digestion, keeps the mouth moist, and protects teeth from decay. Salivary stones, medically termed sialolithiasis, develop when minerals—primarily calcium—gradually crystallize inside these ducts.

Over time, these crystals accumulate, forming hard, chalk-like structures that partially or completely block the flow of saliva. When saliva becomes concentrated—often due to dehydration, reduced fluid intake, or medications that decrease saliva production—minerals are more likely to settle and crystallize.

Slow flow or stagnation within the duct allows these tiny deposits to grow. Previous infections, inflammation, or minor scarring can narrow the duct, further encouraging stone formation. The process is gradual and often silent until the blockage becomes significant.

Symptoms Of Salivary Stone

The symptoms are distinctive. Pain and swelling typically occur during meals, when the glands are stimulated to produce more saliva. If a stone is blocking the duct, saliva cannot escape into the mouth. Pressure builds within the gland, causing swelling and a throbbing ache. The swelling may reduce after some time as saliva slowly seeps past the obstruction, only to recur at the next meal.

In some cases, patients notice a dry mouth, an unpleasant taste, or even pus discharge if infection develops. Because the symptoms come and go, many people delay seeking medical help, assuming it is a temporary issue.

Salivary Stone: Diagnosis and Treatment

Diagnosis today is far more straightforward than it once was. A doctor may sometimes feel a stone during a physical examination inside the mouth or beneath the jaw. Ultrasound scanning is a simple and painless way to detect most stones, while CT scans are useful for identifying deeper or smaller ones.

However, the real breakthrough in both diagnosis and treatment has been sialendoscopy. This technique involves introducing a very thin endoscope—about the size of a delicate wire—directly into the natural opening of the salivary duct inside the mouth. The surgeon can then visualize the duct system from within, identify the exact location of the stone, and in many cases remove it during the same procedure.

Not long ago, treatment options were far more invasive. When stones were deeply lodged or infections recurred, surgeons often removed the entire affected gland.

For the submandibular gland, this required an incision in the neck, a hospital stay, and a recovery period that could last weeks. There was also a significant risk of nerve injury, which could affect tongue movement or lower lip function. While gland excision effectively eliminated the stone, it also meant permanent loss of that gland’s function.

For what is essentially a small obstructing stone, the operation was often disproportionate to the problem. Gland removal also meant a permanent scar on the neck, which can cause significant facial deformity.

Treating Salivary Stone With Sialendoscopy

The advent of sialendoscopy has dramatically changed this landscape. Through the natural duct opening inside the mouth, the surgeon gently widens the duct and introduces the miniature camera. Continuous saline irrigation keeps the view clear.

Once the stone is located, tiny micro-instruments such as baskets or graspers are used to retrieve it. Larger stones can sometimes be fragmented using a LASER before removal.

In addition to extracting stones, sialendoscopy allows the surgeon to dilate narrow ducts, wash out debris, and treat inflammatory conditions. The procedure typically takes less than an hour, is often performed as a day-care surgery, and leaves no external scar.

The benefits of sialendoscopy are substantial. The most important advantage is gland preservation. Instead of sacrificing an entire gland, the obstruction alone is addressed, allowing normal saliva production to continue. There are no visible scars because the procedure is performed entirely through the mouth.

Recovery is typically quick, with most patients resuming normal activities within a day or two. Complication rates are lower compared to open surgery, and success rates are high—often exceeding 90 to 95 percent in appropriately selected cases. Even when stones are larger or located deeper within the gland, sialendoscopy can often be combined with a small intraoral incision, still avoiding external scars and major surgery.

Sialendoscopy and its allied approaches can now tackle almost any stone, whether it’s in the duct or in the gland, with utmost precision, leaving behind a fully functional gland. Despite conventional learnings, even intraglandular stones, large stones, and patients with multiple stones can be effectively treated using this novel technique.

Preventing Salivary Stones

Prevention, while not always possible, can reduce risk. Staying well hydrated helps maintain healthy saliva flow. Good oral hygiene minimizes infection and inflammation within the ducts. Early evaluation of recurrent swelling can prevent chronic damage. Individuals who take medications that reduce saliva production should be particularly mindful of fluid intake and regular dental care.

The story of salivary stones is ultimately one of medical progress. What was once managed through the removal of an entire gland can now often be treated with a fine endoscope and delicate instruments. The transformation has reduced pain, shortened recovery times, minimized complications, and preserved natural gland function.

For patients, it means less anxiety and more confidence in seeking care early. For surgeons, it represents the success of innovation guided by a simple principle: treat precisely, preserve whenever possible, and restore normal function with the least disruption.

Salivary stones may be small, but their impact can be significant. Thanks to sialendoscopy and the expertise of pioneers in the field, patients today have access to safer, more conservative, and highly effective treatment options. In modern salivary gland care, the focus is no longer on removing the gland—it is on saving it.

The consumption of vapes or the practice of vaping has seen a surge among the younger generation. People have often considered vapes to be a substitute for their everyday cigarettes, and therefore, they have replaced their traditional smoking habits. They do not carry the right knowledge about this common practice and fail to take the right measures to cut down on its usage. Research institutions and government bodies are now making collective efforts to establish the facts and make the general populace more aware and healthy.

How Can You Detect The Early Signs Of Oral Cancer?

Oral problems and an increased risk of oral cancer are considered to be the common problems associated with vaping. The presence of harmful chemicals in its formation makes it harmful to the human body. Along with your oral cavity, they can also damage the lining of your mouth. It has been proven that excessive consumption of vapes can lead to an increased risk of oral cancer.

Oral cancer can be prevented with early detection and immediate medical intervention. It can be identified with signs like abnormal bleeding inside the mouth, ulcers that won’t heal, chronic soreness, and red and white patches on the tongue and gums. The common signs are often discarded as an allergy, and people fail to seek the right treatment. Even with the available medical care and support, they are not able to counter this deadly disease.

The Impact of Vaping on Oral Tissues

The risk of vaping is not limited to increased chances of getting oral cancer. It can also impact your overall health. A vape is made with excessive heat and other harmful chemicals, which can damage the tissues of your gums and cause inflammation. It can lead to a condition known as gingivitis. One might also experience a dryness in their mouth, which is caused by reduced saliva production, which is considered to be a defense mechanism against bacterial production.

There can be far-reaching implications of having a constant dry mouth. It can lead to a breeding ground for harmful microbes. It can also increase one’s chances of having tooth decay, foul smell in the mouth, and oral infections.

Also read: Vaping Becomes Major Nicotine Threat Among Children Under 5 in US, Warns Study

The presence of flavoring agents and harmful chemicals in vapes makes them more damaging to the enamel of your teeth. In the short run, it might not seem like a major problem, but it can lead to tooth sensitivity if not handled at the right time.

Which Is More Harmful- Smoking or Vaping?

As the practice of vaping does not include combustion, people consider it safer than regular smoking. They often forget that vapes contain a significant amount of nicotine, which promotes survival and rapid growth of cancerous cells.

Vaping can reduce the blood flow to your gums and affect your healing capabilities. It can also increase your probability of periodontal disease. As the younger generation considers vaping to be a safer alternative, it can lead to its more frequent usage. As vaping does not follow any pattern like traditional smoking, it can be consumed at any time during the day, and increases your exposure to harmful chemicals.

The younger generation has reported an increasing number of oral health issues that are linked to vaping. Some of these problems include inflammation of your gums and decay of

your tooth enamel. As these issues seem visibly minor, they can often get ignored, and the person might not seek the required treatment. Consequently, they might develop long-term oral problems.

The younger generation gets influenced by the internet fads and more affordable alternatives to their daily smoking. As they keep increasing their consumption of vapes, they fail to identify the potential side effects.

Conclusion

The ongoing research has proven that vaping can be detrimental to both your oral and overall health. Research has suggested that this problem is more common among the younger generation, who might feel more inclined to replace the traditional forms of smoking. With ease of usage and accessibility, this malpractice has youngsters across the globe under its grip.

If one does not make the right effort to reduce their usage, it can lead to serious complications in the long run. Both the government officials and healthcare professionals need to spread more awareness about its detrimental effects and make efforts to conduct regular oral checkups. In this way, there will be a community-level effort to put a stop to its usage.

Bob Harris, the renowned BBC Radio 2 host, has informed his listeners of being hospitalized again for prostate cancer treatment.

Posting on social media platform Instagram, Harris said he is receiving treatment for an issue that has developed over the past few weeks.

“As many of you know, I suffer from prostate cancer, and every now and again I experience setbacks that need attention. Now is one of these moments,” he wrote, along with a picture of himself lying in a hospital bed while smiling for the camera.

Harris noted that he’s taking short break away from his programs. However, he confirmed that this week’s Country Show is scheduled as planned, and his Sounds of the 70’s episode on 12th April will feature an 80th birthday celebration special he recorded before attending the C2C Festival with Zoe Ball.

Noting that he can’t state the day of his return as the host, he said: “I know that I will come back… and come back stronger”.

“I hate missing programs and I am keen to get back into the studio as soon as I can”.

Calling himself “blessed” for the support he received from friends and family and listeners of his show, Harris said that during his absence, Darius Rucker will guest on Country, while Shaun Keaveny will cover Sounds of the 70’s for a few weeks.

"I am so blessed to have the love of my family and the support of my friends who have rallied round me at what has proved to be an unexpectedly testing time,” Harris said.

Prostate Cancer: The UK’s Most Common Male Cancer

Prostate cancer remains the most common cancer among men in the UK, with around 55,000 cases diagnosed every year. Despite this, there is currently no national screening program because of concerns over the accuracy of PSA tests.

In November 2025, former UK Prime Minister David Cameron revealed his prostate cancer diagnosis and also called for a targeted screening.

Also read: Joe Biden Is Diagnosed With Aggressive Prostate Cancer: All That You Need To Know

In an interview with Times, he said, "You always hope for the best. You have a high PSA score - that is probably nothing. You have an MRI scan with a few black marks on it. You think, ‘Ah, that’s probably OK.’ But when the biopsy comes back, and it says you have got prostate cancer. You always dread hearing those words. And then literally as they’re coming out of the doctor’s mouth you’re thinking, ‘Oh, no, he’s going to say it. He’s going to say it. Oh God, he said it.’"

The former PM, said that he had a prostate-specific antigen (PSA) test for the screening that looks for proteins associated with the form of the disease. His result was high, and a biopsy after that revealed his cancer.

In October 2024, six-time Olympic gold medallist Chris Hoy revealed he had been diagnosed with terminal stage 4 cancer. His prostate cancer had spread to his shoulder, pelvis, hips, ribs and spine.