Happiness is influenced by a complex interplay of various chemicals in our brain, particularly four key neurotransmitters, D.O.S.E or Dopamine, Oxytocin, Serotonin, and Endorphins. These chemicals, often referred to as "happiness chemicals," are responsible for creating feelings of joy, motivation, connection, and calm.

However, when there's a deficiency in any of these, it can significantly affect our mood, energy, and overall well-being. Let’s dive into what these four neurotransmitters are, how their deficiency impacts us, and how we can boost their levels naturally.

Dopamine: The Motivation and Reward Chemical

Dopamine is often called the "motivation molecule." It plays a major role in enabling motivation, learning, and the pleasure-reward system in the brain. When we accomplish something — whether it’s finishing a project, completing a workout, or achieving a goal — dopamine gives us that sense of satisfaction and determination to continue.

Deficiency Effects:

When dopamine levels are low, it can lead to procrastination, low self-esteem, lack of focus, and general fatigue. A person might feel anxious, hopeless, or experience mood swings because the brain isn’t getting the reward signals it needs.

Boosting Dopamine:

You can increase dopamine levels by setting and achieving small goals, exercising regularly, eating foods rich in L-Tyrosine (such as almonds, avocados, and eggs), and practicing mindfulness or meditation. Engaging in creative activities like writing or drawing also helps boost dopamine levels.

Oxytocin: The Bonding Chemical

Oxytocin is often referred to as the "love hormone" or "cuddle hormone" because it plays a major role in social bonding and trust. It’s released when we hug, touch, or engage in other forms of physical affection. Oxytocin fosters feelings of connection and emotional intimacy, making it essential for relationships, family bonding, and even team cooperation.

Deficiency Effects:

A lack of oxytocin can lead to feelings of loneliness, stress, anxiety, and difficulties in forming or maintaining relationships. Low oxytocin levels are associated with feelings of isolation and disconnection from others.

Boosting Oxytocin:

You can raise your oxytocin levels through physical touch, socialising, spending quality time with loved ones, and even engaging in activities like massage or listening to soothing music. Acts of kindness, such as helping others or volunteering, also help release oxytocin.

Serotonin: The Mood Stabiliser

Serotonin is responsible for feelings of well-being and contentment. It helps regulate mood, sleep, digestion, and even social behavior. People who have balanced serotonin levels often feel calm, confident, and emotionally stable. Serotonin is crucial in helping people feel valued and significant among their peers.

Deficiency Effects:

Low serotonin levels are linked to depression, low self-esteem, irritability, and mood swings. Individuals may feel overly sensitive to criticism, experience panic attacks, or struggle with social phobias when serotonin is deficient.

Boosting Serotonin:

You can boost serotonin by getting regular exercise, exposing yourself to sunlight, engaging in cold showers or massages, and practicing mindfulness. Simple activities like walking in nature, meditating, or doing yoga are also effective serotonin enhancers.

Endorphins: The Pain Reliever

Endorphins are the body’s natural painkillers. Released in response to stress, pain, or intense physical activity, they help alleviate discomfort and promote a sense of euphoria. Endorphins are what make you feel good after a workout or a hearty laugh, often referred to as the "runner's high."

Deficiency Effects:

Without enough endorphins, people may experience anxiety, depression, chronic pain, and insomnia. A deficiency in endorphins can make daily life feel overwhelming and physically draining.

Boosting Endorphins:

To boost endorphins, engage in laughter, exercise, and stretching activities. Eating spicy foods or dark chocolate can also stimulate endorphin production. Regular massage therapy and meditation are other ways to naturally elevate endorphin levels.

Male infertility remains a topic rarely discussed, often overshadowed by social pressures and hesitation. Yet, it contributes to nearly half of all cases where couples struggle to conceive. Among the many causes, varicocele stands out as one of the most silent and underrecognised conditions, affecting a significant number of men in India.

With male reproductive health still a taboo, countless men remain unaware of their condition for years. Fertility tests often reveal the issue only after prolonged delays, adding emotional stress for couples. We got in touch with Dr. Suparna Bhattacharya, Fertility Specialist, Nova IVF Fertility, Kolkata, who told us more about the same.

What Is a Varicocele?

A varicocele occurs when the veins in the scrotum become enlarged, similar to varicose veins in the legs. These weakened, dilated veins disrupt blood flow to the testicles, causing a gradual rise in temperature that negatively affects sperm production and quality. Most men experience no pain, which is why the condition is often undetected, earning it the label of a “silent” problem. In many cases, it is discovered only during routine infertility evaluations.

Why It’s a Common Yet Ignored Cause of Male Infertility

Varicocele is particularly concerning because it often goes untreated, leading to more serious reproductive consequences. Dr. Suparna Bhattacharya said, “The condition may not produce noticeable symptoms—no pain, no swelling—yet internally, impaired blood flow and heat buildup gradually reduce sperm count, motility, and quality. Research shows varicocele accounts for a large proportion of male infertility cases, and the condition is largely reversible if identified early.”

A lack of awareness, coupled with the common misconception that infertility is primarily a female issue, often delays evaluation of the male partner. Many men only undergo semen analysis or scrotal ultrasound after significant time has passed.

Can Surgery Restore Fertility?

The encouraging news is that varicocele is one of the few male infertility issues that can be effectively treated with surgery. Varicocelectomy, the most common procedure, involves tying off the affected veins while preserving normal blood flow. This helps cool the scrotum and allows sperm production to return to healthier levels.

Dr. Suparna Bhattacharya told us that post-surgery, many men experience notable improvements in sperm count and motility within six months. For couples, this can mean natural conception without advanced fertility treatments. Correcting varicocele can also improve sperm DNA integrity, enhancing the success rates of procedures like IVF or ICSI.

Potential Consequences of Untreated Varicocele

Not all varicoceles require surgery, especially if mild or asymptomatic. However, undetected or significant varicoceles can progressively impair sperm quality and, in some cases, lead to testicular atrophy. Delayed diagnosis can reduce the likelihood of natural conception as men age.

When Should You See a Doctor?

Men who have been trying to conceive for over a year should undergo a comprehensive fertility check-up. A simple semen analysis and physical examination are often sufficient to detect most varicoceles. “Early intervention is crucial, particularly for those hoping for natural conception or planning to start a family,” said Dr. Suparna Bhattacharya

Promoting awareness about male reproductive health is just as important as educating women on fertility. Varicocele is a silent, yet easily treatable, condition. Timely diagnosis and treatment can restore fertility and reduce the emotional and financial strain on couples. The first step toward healthier, happier families is acknowledging the issue, seeking treatment, and discussing it openly.

Anyone who relies on ibuprofen, naproxen or ordinary-strength aspirin for pain or arthritis has been advised to be cautious, after an NHS doctor raised concerns about the risks of long-term use. Dr Mark Porter, a GP known for his appearances on The One Show, said many people do not realise these medicines can lead to stomach ulcers and internal bleeding.

He noted that bleeding in the stomach or upper gut is a serious medical emergency. An audit led by researchers at the University of Oxford shows that this type of bleeding leads to at least 60,000 hospital admissions each year, and about one in ten patients does not survive to return home.

NHS Doctors Issue Warning for Anyone Using Ibuprofen, Naproxen or Aspirin

Dr Porter referenced a report published in the journal Gut, which compared outcomes from 2007 and 2022. The data revealed how many people who suffered gut bleeds were taking medicines, both prescribed and over the counter, that could trigger or worsen the problem.

As per Times,, he said that nearly half of the 5,141 patients analysed in the audit had been taking some type of drug that increases the chance of bleeding. These included low-dose aspirin, clopidogrel and anticoagulants such as warfarin and apixaban. In addition, one in fourteen patients had been using a non-steroidal anti-inflammatory drug (NSAID) like ibuprofen, naproxen or normal-dose aspirin, which are commonly used to relieve pain and treat arthritis.

Why NSAIDs Can Be More Dangerous Than People Realise

Dr Porter said many people who take low-dose aspirin or blood thinners to lower the risk of stroke, heart attack or blood clots know that these medicines carry a bleeding risk. The concern is that far fewer people understand that NSAIDs can be just as harmful for some individuals. According to him, NSAIDs are responsible for about a third of all NHS hospital admissions linked to adverse drug reactions. These admissions take up roughly one in five hospital beds. Beyond gut bleeding, NSAIDs can also raise the chance of heart attacks, strokes and kidney problems.

Stomach Symptoms Can Worsen With Long-Term Use

People who already struggle with heartburn or indigestion often notice that occasional ibuprofen or aspirin makes their symptoms worse. Dr Porter explained that, when taken frequently or over long periods, these medicines can do much more damage. Their effect on prostaglandins, which helps ease pain, also weakens the stomach’s natural defences against its own acids. This can lead to irritation, ulcers, bleeding and in some cases, a perforation.

He added that although the overall risk for most people is small, doctors have become more aware of these dangers. As a result, NSAID use has fallen in many countries over the past 25 years. Even so, these drugs are still widely prescribed, especially for older adults. Some estimates suggest that nearly one in five people over 65 has taken at least one course in the past year.

Why Protective Medicines Do Not Remove All Risks

Doctors often prescribe antacid medicines such as omeprazole alongside stronger NSAIDs like naproxen to help protect the stomach. Dr Porter clarified that these medicines lower the risk of bleeding, but they do not remove it fully. He said certain groups should be particularly careful.

These include people on low-dose aspirin or similar drugs like clopidogrel, anyone taking anticoagulants such as warfarin or apixaban, those who often have indigestion or heartburn, anyone with a history of stomach or duodenal ulcers, people living with heart failure or chronic kidney disease, and adults over 65 who are not taking stomach-protective medication.

Aspirin Should Not Be Taken Casually

Dr Porter added that one painkiller should never be taken without a doctor’s instruction. He said he would avoid using aspirin for day-to-day discomfort unless advised by a medical professional. For issues such as a hangover, a headache or a sore knee, paracetamol is usually safer than ibuprofen, although it may not offer the same level of relief. An occasional NSAID is unlikely to cause harm for most people, as long as they are not in a high-risk group. However, anyone who needs pain relief often, whether daily or several times a week, should speak to their GP to decide on a safer plan.

Dr Porter offered one final piece of advice. While vomiting blood is an obvious emergency, an earlier sign of slow bleeding in the upper gut can be easy to miss. Black, tar-like stools, known as melena, should never be ignored. Anyone who notices this should seek medical help without delay.

Blood pressure shifts throughout the day in a steady rhythm shaped by hormones, activity, and the body’s internal clock. Doctors call this the circadian pattern of blood pressure. It helps the body prepare for wakefulness, support daytime tasks, and recover during sleep.

While this rise and fall is normal, the timing of these changes matters, especially for people with hypertension or heart conditions. Dr Sunil Rana, Associate Director and Head of Internal Medicine (Unit III), Asian Hospital, explains how these variations unfold across a typical day.

Why Blood Pressure Peaks in the Early Morning

In a normal cycle, the highest readings appear between six in the morning and nine in the morning. This is the point when the body shifts from sleep to wakefulness. Hormones such as cortisol and adrenaline surge during these hours. They raise the heart rate and tighten blood vessels to help the body feel alert.

Dr Sunil Rana said, “This rise is natural, yet it carries added importance for people with hypertension, diabetes, sleep disorders, or heart disease. During these early hours, the risk of heart attack, stroke, and other vascular complications is known to be higher because the body is under greater strain.”

How Daytime Habits Shape Midday and Afternoon Readings

After the morning peak, blood pressure usually settles into a moderate range through the late morning and early afternoon. Daily tasks like walking, working, travel, and problem-solving maintain a steady level. At the same time, several routine triggers can push these numbers higher. Mental stress, dehydration, caffeine, skipped meals, and long periods of sitting often raise readings through the day.

Dr Sunil Rana, told us that people who face chronic stress, irregular work hours, or disrupted eating patterns tend to see wider swings. Toward late afternoon, blood pressure usually dips slightly as the body begins to wind down. However, heavy meals, alcohol, emotional tension, or intense workouts in the evening can cause short-lived spikes.

Why Blood Pressure Falls at Night?

During sleep, the body enters a quieter phase known as nocturnal dipping, where blood pressure typically drops by ten to twenty percent. This drop gives the heart and blood vessels a chance to rest. The dip is an important part of cardiovascular recovery.

Dr Sunil Rana said, “Not everyone experiences this nightly reduction. People with kidney disease, diabetes, sleep apnea, or autonomic dysfunction may show little or no dip at night, which is linked to a greater risk of long-term heart problems. Irregular sleep routines, late-night screen use, and chronic insomnia can also disrupt this natural decline and keep nighttime readings higher than expected.”

Factors That Influence These Daily Changes

The steepness of these fluctuations differs from person to person. Age, lifestyle, food habits, alcohol, smoking, weight, and stress all play a part. Night-shift workers may show the reverse pattern, with pressure rising at night instead of morning. Medication timing also shapes the curve, especially in people who take antihypertensive drugs.

Doctors often advise checking blood pressure at different times of the day, including early morning and before bedtime, to understand a person’s individual rhythm more clearly.

Understanding that blood pressure is naturally highest in the early morning helps in planning treatment and daily routines. It guides medication timing, supports healthier morning habits, and strengthens long-term control. It also helps people at higher risk take steps to protect their heart during the hours when it needs the most support.