Happiness is influenced by a complex interplay of various chemicals in our brain, particularly four key neurotransmitters, D.O.S.E or Dopamine, Oxytocin, Serotonin, and Endorphins. These chemicals, often referred to as "happiness chemicals," are responsible for creating feelings of joy, motivation, connection, and calm.

However, when there's a deficiency in any of these, it can significantly affect our mood, energy, and overall well-being. Let’s dive into what these four neurotransmitters are, how their deficiency impacts us, and how we can boost their levels naturally.

Dopamine: The Motivation and Reward Chemical

Dopamine is often called the "motivation molecule." It plays a major role in enabling motivation, learning, and the pleasure-reward system in the brain. When we accomplish something — whether it’s finishing a project, completing a workout, or achieving a goal — dopamine gives us that sense of satisfaction and determination to continue.

Deficiency Effects:

When dopamine levels are low, it can lead to procrastination, low self-esteem, lack of focus, and general fatigue. A person might feel anxious, hopeless, or experience mood swings because the brain isn’t getting the reward signals it needs.

Boosting Dopamine:

You can increase dopamine levels by setting and achieving small goals, exercising regularly, eating foods rich in L-Tyrosine (such as almonds, avocados, and eggs), and practicing mindfulness or meditation. Engaging in creative activities like writing or drawing also helps boost dopamine levels.

Oxytocin: The Bonding Chemical

Oxytocin is often referred to as the "love hormone" or "cuddle hormone" because it plays a major role in social bonding and trust. It’s released when we hug, touch, or engage in other forms of physical affection. Oxytocin fosters feelings of connection and emotional intimacy, making it essential for relationships, family bonding, and even team cooperation.

Deficiency Effects:

A lack of oxytocin can lead to feelings of loneliness, stress, anxiety, and difficulties in forming or maintaining relationships. Low oxytocin levels are associated with feelings of isolation and disconnection from others.

Boosting Oxytocin:

You can raise your oxytocin levels through physical touch, socialising, spending quality time with loved ones, and even engaging in activities like massage or listening to soothing music. Acts of kindness, such as helping others or volunteering, also help release oxytocin.

Serotonin: The Mood Stabiliser

Serotonin is responsible for feelings of well-being and contentment. It helps regulate mood, sleep, digestion, and even social behavior. People who have balanced serotonin levels often feel calm, confident, and emotionally stable. Serotonin is crucial in helping people feel valued and significant among their peers.

Deficiency Effects:

Low serotonin levels are linked to depression, low self-esteem, irritability, and mood swings. Individuals may feel overly sensitive to criticism, experience panic attacks, or struggle with social phobias when serotonin is deficient.

Boosting Serotonin:

You can boost serotonin by getting regular exercise, exposing yourself to sunlight, engaging in cold showers or massages, and practicing mindfulness. Simple activities like walking in nature, meditating, or doing yoga are also effective serotonin enhancers.

Endorphins: The Pain Reliever

Endorphins are the body’s natural painkillers. Released in response to stress, pain, or intense physical activity, they help alleviate discomfort and promote a sense of euphoria. Endorphins are what make you feel good after a workout or a hearty laugh, often referred to as the "runner's high."

Deficiency Effects:

Without enough endorphins, people may experience anxiety, depression, chronic pain, and insomnia. A deficiency in endorphins can make daily life feel overwhelming and physically draining.

Boosting Endorphins:

To boost endorphins, engage in laughter, exercise, and stretching activities. Eating spicy foods or dark chocolate can also stimulate endorphin production. Regular massage therapy and meditation are other ways to naturally elevate endorphin levels.

Concerns around fertility and vaccines often surface when people plan a family, and the HPV vaccine is no exception. Many women and men worry that getting vaccinated today could affect their ability to conceive later in life. Medical experts, however, say this fear is misplaced. According to fertility specialists, there is no evidence linking the HPV vaccine to reduced fertility. In fact, the vaccine may play a quiet but important role in protecting reproductive health over the long term.

Does The HPV Vaccine Affect Fertility?

The short and clear answer is no. The HPV vaccine does not negatively affect fertility in women or men. Dr. Madhu Patil, Consultant and Fertility Specialist at Motherhood Fertility and IVF, Sarjapur, Bangalore, explains that there is no scientific proof showing the vaccine causes fertility problems of any kind.

She notes that concerns often arise from misinformation rather than medical data. Extensive research and global vaccination programmes have consistently shown that people who receive the HPV vaccine do not experience reduced chances of conceiving in the future.

How HPV Infection Can Threaten Future Fertility

While the vaccine itself does not harm fertility, an untreated HPV infection can. HPV is the leading cause of nearly all cervical cancer cases. As per Dr Patil, “treatment for cervical cancer often involves procedures such as cone biopsy or LEEP, which can weaken the cervix. In more advanced cases, radiation or chemotherapy may be required.”

These treatments can reduce a woman’s ability to conceive and, in some cases, make it difficult to carry a pregnancy to full term. By preventing HPV-related cancers in the first place, the vaccine helps preserve the reproductive system and lowers the risk of fertility-compromising treatments later in life.

Why The HPV Vaccine Supports Reproductive Health

Dr. Patil points out that the HPV vaccine should be viewed as a protective measure rather than a risk. By stopping high-risk HPV strains from causing cancer or precancerous changes, the vaccine helps maintain cervical health. A healthy cervix and reproductive system are key factors in natural conception and safe pregnancies.

In this way, the vaccine indirectly supports fertility by reducing the likelihood of medical interventions that could interfere with reproductive function.

When Should the HPV Vaccine Be Taken?

Health experts recommend starting HPV vaccination at ages 11 or 12. At this stage, the immune response is strongest, and the vaccine offers protection well before any potential exposure to the virus. Dr. Patil strongly encourages parents to consult a gynaecologist and consider timely vaccination for their children.

That said, adults who missed vaccination earlier can still benefit. Many women and men receive the vaccine later in life after discussing it with their doctor.

Why Men Should Also Get The HPV Vaccine

The HPV vaccine is not only for women. Dr. Patil stresses that men should also be vaccinated, as HPV can cause cancers and genital warts that affect sexual health. Vaccination in men also reduces transmission to partners, adding another layer of protection for couples planning a family.

By limiting the spread of HPV, vaccination helps safeguard the reproductive and sexual health of both partners.

There is no evidence that the HPV vaccine reduces fertility. On the contrary, it helps prevent cancers and medical treatments that can threaten the ability to conceive or carry a pregnancy. Experts advise speaking with a gynaecologist, understanding the benefits, and making an informed decision based on medical facts rather than fear.

A three-year-old girl was left partially blind after what first seemed like a routine ear infection was later diagnosed as a life-threatening brain tumour. As per Express UK, Chloe Kefford was rushed to A&E when she started experiencing car sickness and balance problems. Doctors initially diagnosed her with an ear infection and sent her home with antihistamines. But as Chloe’s condition worsened, her parents insisted on further testing, which revealed a tumour affecting her optic nerve.

Ear Infection Symptoms Masked A Life-Threatening Diagnosis

Chloe, from Formby, Merseyside, underwent open brain surgery and faced three-and-a-half years of treatment, including proton beam therapy last year, after experiencing two relapses. Proton beam therapy uses high-energy protons to precisely target the tumour, limiting damage to surrounding healthy tissue.

Open Brain Surgery And Years Of Intensive Treatment Followed

Now nine years old, Chloe has been honoured with a special award from Cancer Research UK for her bravery throughout her treatment. She received her initial care at St George’s Hospital in London and The Royal Marsden, before being transferred to Alder Hey in Liverpool.

Proton Beam Therapy Used After Cancer Relapsed Twice

Chloe’s mother, Nikki, 38, recalled that the family had been planning a move from Surrey to Merseyside before Chloe fell ill. As per Express UK, she said: “The house was already sold and we were planning our new life by the beach when Chloe became ill. Then we ended up moving and having to isolate for months. She relapsed not long after we moved and had more chemotherapy, then she rang the bell in April last year, but unfortunately, she relapsed again in July. So, we were supposed to be going on holiday to Disneyland in Paris and instead we went to Manchester for six weeks for Chloe to have proton beam therapy.”

Nikki added: “She is partially sighted now and has no peripheral vision; one eye is particularly badly affected. The main aim now is to preserve what eyesight she has left. We’re hopeful that the recent targeted treatment has got the cancer once and for all. She’s on steroids at the moment and is being monitored with three-monthly scans. She’s still in recovery and struggles with fatigue from the treatment, but we hope she’ll have a bit more energy soon. She’s our little ray of sunshine.”

Each year, around 400 children and young people in the North West are diagnosed with cancer. Advances in treatment and research are helping make therapies more effective and less harmful. Alder Hey Children’s Hospital in Liverpool is one of several centres across the UK taking part in pioneering clinical trials offering innovative new treatments.

In 2018, Cancer Research UK launched the Children’s Brain Tumour Centre of Excellence, supported by TK Maxx. The virtual centre brings together international experts in children’s brain tumour research to transform how treatments are developed. Every child nominated for a Star Award receives this recognition, which is endorsed by celebrities including JoJo Siwa and Pixie Lott.

Cancer Research UK spokesperson Jemma Humphreys said: “After everything Chloe’s been through, it’s been an absolute privilege to celebrate her incredible courage with a Star Award.”

People experiencing certain symptoms are being urged to stay at home as a highly contagious virus spreads quickly across England. Fresh figures from the UK Health Security Agency show a 47% rise in cases during the first two weeks of 2026. This sudden jump has led the agency to remind the public about basic hygiene steps that play a key role in limiting the spread. Data suggests that norovirus is affecting people aged 65 and above the most, and although overall activity remains within normal seasonal levels, there has been a noticeable increase in outbreaks in hospital settings.

The latest UKHSA surveillance update also points to falling levels of flu, COVID-19, and RSV in the opening week of the year. While all winter virus levels are currently where they would be expected for this time of year, people are being encouraged to continue following simple precautions to help keep infections on a downward path.

What Is Norovirus?

Norovirus Symptoms

Common symptoms of norovirus include:

• Nausea.
• Vomiting.
• Diarrhoea.
• Stomach pain.

You may also experience:

• Headache.
• Fever.
• Body aches.

Symptoms usually develop between 12 and 48 hours after exposure and typically last for one to three days.

Doctors Report New Symptoms Of Norovirus

Both flu and norovirus can behave unpredictably, with case numbers rising and falling throughout the season. This makes simple preventive steps especially important. For illnesses affecting the stomach or respiratory system, such as norovirus, regular handwashing remains one of the most effective measures.

Health experts stress that alcohol-based hand sanitisers do not work against norovirus. Washing hands thoroughly with soap and warm water, along with cleaning surfaces using bleach-based products, is far more effective in reducing the spread. Good ventilation indoors can also help limit the transmission of respiratory viruses like flu. Anyone who develops symptoms is advised to stay at home whenever possible.

If going out cannot be avoided, wearing a face covering may help, particularly when around people who are more vulnerable.

Amy Douglas, Lead Epidemiologist at the UKHSA, said, according to the Mirror: “We have seen a clear rise in norovirus cases in recent weeks, particularly among people aged 65 and over, alongside an increase in hospital outbreaks. Although levels are still within what we would normally expect, there are simple actions people can take to stop norovirus spreading further.

“Washing hands with soap and warm water and cleaning surfaces with bleach-based products are key steps. Alcohol gels do not kill norovirus, so they should not be relied on alone.

“If you have diarrhoea and vomiting, do not return to work, school, or nursery until 48 hours after symptoms have stopped, and avoid preparing food for others during this time. If you are unwell, please stay away from hospitals and care homes to protect those most at risk from infection.”