Happiness is influenced by a complex interplay of various chemicals in our brain, particularly four key neurotransmitters, D.O.S.E or Dopamine, Oxytocin, Serotonin, and Endorphins. These chemicals, often referred to as "happiness chemicals," are responsible for creating feelings of joy, motivation, connection, and calm.

However, when there's a deficiency in any of these, it can significantly affect our mood, energy, and overall well-being. Let’s dive into what these four neurotransmitters are, how their deficiency impacts us, and how we can boost their levels naturally.

Dopamine: The Motivation and Reward Chemical

Dopamine is often called the "motivation molecule." It plays a major role in enabling motivation, learning, and the pleasure-reward system in the brain. When we accomplish something — whether it’s finishing a project, completing a workout, or achieving a goal — dopamine gives us that sense of satisfaction and determination to continue.

Deficiency Effects:

When dopamine levels are low, it can lead to procrastination, low self-esteem, lack of focus, and general fatigue. A person might feel anxious, hopeless, or experience mood swings because the brain isn’t getting the reward signals it needs.

Boosting Dopamine:

You can increase dopamine levels by setting and achieving small goals, exercising regularly, eating foods rich in L-Tyrosine (such as almonds, avocados, and eggs), and practicing mindfulness or meditation. Engaging in creative activities like writing or drawing also helps boost dopamine levels.

Oxytocin: The Bonding Chemical

Oxytocin is often referred to as the "love hormone" or "cuddle hormone" because it plays a major role in social bonding and trust. It’s released when we hug, touch, or engage in other forms of physical affection. Oxytocin fosters feelings of connection and emotional intimacy, making it essential for relationships, family bonding, and even team cooperation.

Deficiency Effects:

A lack of oxytocin can lead to feelings of loneliness, stress, anxiety, and difficulties in forming or maintaining relationships. Low oxytocin levels are associated with feelings of isolation and disconnection from others.

Boosting Oxytocin:

You can raise your oxytocin levels through physical touch, socialising, spending quality time with loved ones, and even engaging in activities like massage or listening to soothing music. Acts of kindness, such as helping others or volunteering, also help release oxytocin.

Serotonin: The Mood Stabiliser

Serotonin is responsible for feelings of well-being and contentment. It helps regulate mood, sleep, digestion, and even social behavior. People who have balanced serotonin levels often feel calm, confident, and emotionally stable. Serotonin is crucial in helping people feel valued and significant among their peers.

Deficiency Effects:

Low serotonin levels are linked to depression, low self-esteem, irritability, and mood swings. Individuals may feel overly sensitive to criticism, experience panic attacks, or struggle with social phobias when serotonin is deficient.

Boosting Serotonin:

You can boost serotonin by getting regular exercise, exposing yourself to sunlight, engaging in cold showers or massages, and practicing mindfulness. Simple activities like walking in nature, meditating, or doing yoga are also effective serotonin enhancers.

Endorphins: The Pain Reliever

Endorphins are the body’s natural painkillers. Released in response to stress, pain, or intense physical activity, they help alleviate discomfort and promote a sense of euphoria. Endorphins are what make you feel good after a workout or a hearty laugh, often referred to as the "runner's high."

Deficiency Effects:

Without enough endorphins, people may experience anxiety, depression, chronic pain, and insomnia. A deficiency in endorphins can make daily life feel overwhelming and physically draining.

Boosting Endorphins:

To boost endorphins, engage in laughter, exercise, and stretching activities. Eating spicy foods or dark chocolate can also stimulate endorphin production. Regular massage therapy and meditation are other ways to naturally elevate endorphin levels.

Systematic Lupus Erythematosus (SLE), also known as Lupus, is a multisystem autoimmune disease in which one's immune system attacks the body. It is most common in women of reproductive age; however, in rare cases, it can present in men and patients of any age.

Lupus Symptoms: More Than Just Joint Pain

Symptoms for SLE can range from unexplained fever for days to months, to oral ulcers, malar rash, photosensitivity (after exposure to sun), hair loss, headache, stroke, seizure, abnormal behavior (psychiatry lupus). A large group of patients experiences joint swelling, pain, and fatigue. If the kidneys are affected in Lupus patients, they can pass blood with their urine.

Their urine output also decreases; their legs swell, and there is swelling around the eyes. Involvement of the heart, brain, and pancreas is also not uncommon. Lupus is one of the causes of multiple unexplained pregnancy losses, especially in the second trimester, but with proper treatment and observation, many patients do well and have an uneventful pregnancy and childbirth.

Common Myths About Lupus

Some very prominent myths about SLE need to be debunked. Many think SLE is contagious and that only women can get it, when in reality, neither is true. Being an autoimmune disease means it cannot spread by contact, and it impacts both men and women, although the incidence rate of SLE is higher for women. Many also believe in the common misconception that it affects only joints, when in reality it is a multisystem disease that can affect the kidneys, heart, brain, skin, and lungs.

There is a common myth that pregnancy is impossible or unsafe for women with Lupus; however, many women with Lupus can conceive and experience safe and healthy full-term pregnancies under the right medical guidance. Kidney biopsy, which is a required test for treating Lupus, is often deemed unsafe, but it is a safe test and is required to decide the stage of the disease and treatment.

Lupus: Warning Signs

Some symptoms that can be a cause of alarm in SLE are rapid rising serum creatinine, new onset seizure or psychosis, sudden onset shortness of breath associated with chest pain, blood in cough with low oxygen saturation, acute confusional state with fever, vision changes, severe abdominal pain, unexplained severe anemia, severe thrombocytopenia (platelet count < 20,000).

Managing Lupus

For accurate diagnosis and treatment, one needs a rheumatologist's consultation. Rheumatologists will decide the plan of treatment to manage symptoms, reduce inflammation, prevent flares of the disease, and minimize organ damage. Lifestyle measures like avoiding Sun exposure, quitting smoking, lowering stress, and engaging in some low-impact physical activities help patients to minimize the disease burden.

There is very little awareness about Lupus in society, and due to varied presentations and symptoms, patients often consult with multiple doctors of different specialties before consulting with rheumatologists. We need to push for more awareness in society about less talked-about ailments like Lupus, which needs efficient intervention and management, as it is a lifelong condition. Talking about it also helps reduce stigma and bust myths around it. Late diagnosis and delay in treatment can cause significant morbidity, disease progression, and mortality. With early diagnosis and optimal treatment.

Holistic care is possible, which goes a long way in helping individuals manage autoimmune conditions like Lupus

(By Dr Niharika Gill, Rheumatologist, Lilavati Hospital and Research Center, Mumbai)

Prostate cancer presents a troubling paradox. It is among the most treatable cancers when detected early, with survival rates exceeding 99% at five years. Yet it continues to be a major cause of cancer-related deaths among men worldwide.

The challenge is not always the aggressiveness of the disease; it is the fact that prostate cancer often develops quietly, with symptoms that are easy to overlook or dismiss.

When Cancer Doesn't Make a Sound?

The prostate is located deep within the pelvis, beneath the bladder and surrounding the urethra. In its early stages, prostate cancer typically causes little to no discomfort. Small tumors rarely affect nearby nerves or tissues, allowing the disease to progress unnoticed.

Even when symptoms do appear, they are often mistaken for natural signs of ageing. Changes such as a weaker urine stream, increased frequency of urination, urgency, or waking up several times at night are commonly associated with benign prostate enlargement. This condition affects many men as they grow older. As a result, warning signs are frequently ignored or attributed to age-related changes rather than investigated further.

Unfortunately, more alarming symptoms, including blood in the urine or semen, persistent bone pain, unexplained weight loss, or difficulty passing urine, often emerge only when the disease has advanced beyond the prostate.

Why Men Delay Seeking Help

Biology is only part of the story. Social and psychological factors play an equally important role in delayed diagnosis.

Many men are conditioned to endure discomfort rather than seek medical attention. Persistent messages around toughness and self-reliance can discourage conversations about health concerns, particularly when symptoms involve urinary or sexual function.

Fear also contributes to postponement. Some men worry about receiving a cancer diagnosis, while others are concerned about potential treatment side effects such as urinary incontinence or erectile dysfunction. For many, avoiding the test feels easier than confronting the possibility of bad news.

A lack of awareness further compounds the problem. Unlike heart health or diabetes, prostate health is rarely discussed openly. Many men are unfamiliar with the prostate gland, its role in the body, or the importance of prostate-specific antigen (PSA) testing.

The Role of Stigma and Social Barriers

Symptoms linked to urinary or sexual health often carry an element of embarrassment, making men less likely to discuss them with friends, family members, or healthcare professionals.

Additionally, many men prioritize work and family responsibilities over their own health. Preventive screening may be viewed as unnecessary, especially when symptoms seem minor or absent. This tendency can delay diagnosis until the disease reaches a more advanced stage.

Health disparities also play a role. Certain populations face higher risks of developing and dying from prostate cancer, yet often experience lower rates of screening and healthcare access, highlighting the need for more targeted awareness efforts.

Challenges Within the Healthcare System

Unlike some other cancers, prostate cancer screening recommendations are not universally standardized. Decisions around PSA testing are often based on age, risk factors, and individual discussions between patients and healthcare providers.

Because symptoms frequently overlap with benign conditions such as urinary tract infections or prostate enlargement, prostate cancer may not always be suspected immediately. Furthermore, many men do not attend regular health check-ups, reducing opportunities for early detection and informed conversations about risk.

Who Should Be Particularly Vigilant?

While all men should be aware of prostate health, certain groups face a higher risk of developing the disease:

• Men over the age of 50
• Individuals with a father, brother, or close relative diagnosed with prostate cancer
• Men carrying inherited genetic mutations such as BRCA2
• Those with obesity, smoking habits, or diets high in processed foods and saturated fats

Breaking the Silence

Improving outcomes starts with changing the conversation around prostate health. Rather than viewing screening as a response to illness, it should be considered part of routine preventive healthcare, similar to monitoring blood pressure, cholesterol, or blood sugar levels. Men should feel comfortable discussing urinary changes, however minor they may seem, with their healthcare providers.

Public awareness campaigns, workplace screening initiatives, and community outreach programs can play a vital role in normalizing conversations around prostate health. Equally important are personal stories from survivors and public figures, which can encourage others to seek timely medical advice.

The Difference Early Detection Makes

When prostate cancer is identified at an early stage, treatment options are often less invasive and highly effective, ranging from active surveillance to curative surgery or radiation therapy. Survival outcomes are excellent.

In contrast, advanced prostate cancer may require long-term hormone therapy, chemotherapy, and ongoing management of symptoms that significantly affect quality of life. The burden extends beyond health, impacting emotional well-being, family life, and financial stability.

A Message Every Man Should Hear

Prostate cancer often develops without obvious warning signs, making awareness and proactive screening essential. The goal is not to create fear, but to empower men to take charge of their health before symptoms become impossible to ignore.

When it comes to prostate cancer, the conversation should begin long before the disease announces itself.

Not long ago, heatstroke was something most people associated with spending hours outdoors in scorching heat. That picture has changed.

Heatwaves today are longer, more intense, and more frequent than they used to be. Heat-related illnesses are showing up across all age groups, and what makes heatstroke particularly dangerous is how quietly it can creep up. The body usually sends warning signals well before things get serious, but those signals get mistaken for tiredness, dehydration, or just an off day.

Catching them early can stop a medical emergency before it happens.

It Is More than Just Feeling Hot

Heatstroke happens when the body loses its ability to regulate temperature, and the core temperature starts climbing rapidly. Unlike heat exhaustion, which is uncomfortable but manageable, heatstroke is a genuine medical emergency. Left unaddressed, it can affect the brain, heart, kidneys, and other vital organs.

Most people wait for dramatic symptoms before taking it seriously. The early signs, however, are often anything but dramatic.

Warning Signs People Keep Dismissing

One of the earliest signals is feeling unusually wiped out. If someone who is normally active suddenly feels drained after doing very little, the body may be struggling to handle the heat. This often comes with dizziness, weakness, or a light-headed feeling that is hard to shake.

Persistent headaches are another sign that tends to get ignored. People blame them on poor sleep, stress, or not drinking enough water, and carry on with their day. But a headache that keeps coming back during extreme heat can mean the body is under real strain.

Other signs worth watching out for:

- Excessive thirst or a noticeably dry mouth

- Muscle cramps, especially in the legs

- Nausea or a sudden loss of appetite

- Reduced sweating even when feeling very hot

- Difficulty concentrating or feeling unexpectedly confused

On their own, each of these can seem minor. Together, they can be a sign that the body's cooling system is starting to give way.

When Things Turn Serious

As heatstroke progresses, the symptoms become harder to miss. A very high body temperature, a racing heartbeat, flushed skin, confusion, slurred speech, or out-of-character behavior are all red flags.

One of the more dangerous aspects of heatstroke is that the mental changes can be subtle enough to be mistaken for exhaustion. A person may seem disoriented, unusually irritable, or unable to think straight. Family members sometimes put it down to tiredness when it may actually mean the brain is being affected by a rapidly rising body temperature. That distinction matters.

Who Needs to Be Most Careful

Anyone can develop heatstroke, but some people carry a higher risk. Older adults, young children, outdoor workers, athletes, and people living with chronic conditions like heart disease, diabetes, or kidney disorders are particularly vulnerable. Certain medications, including diuretics and some psychiatric drugs, can also reduce the body's ability to manage temperature and stay hydrated.

Simple Steps That Make a Real Difference

Drink water throughout the day, not just when you feel thirsty. Avoid being outdoors during the hottest part of the afternoon. Wear loose, breathable clothing and get to a cool or shaded space when you can.

More than anything, pay attention to what your body is telling you. Heatstroke rarely arrives without warning. Unusual fatigue, dizziness, a persistent headache, or sudden confusion during hot weather are not things to push through and ignore.

The Bottom Line

Heatstroke is no longer an occasional summer story. As temperatures keep climbing, it is becoming a public health concern that touches more people every year.

The early warning signs are there if you know what to look for. Recognizing them and acting quickly can be the difference between recovering at home and ending up in a hospital.