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A new study published in The Lancet Digital Health suggests that biological age of different organs could predict a person's risk of diseases such as cancer, dementia, and heart disease than their actual chronological age. The research analyzed long-term data from Whitehall II study, which had been followed by over 10,000 British adults for more than 35 years.
The blood plasma samples were collected between 1997 and 1999 from participants between ages 45 to 69. Researchers have now examined a follow up data from 6,235 participants, who were by then aged 65 to 89. This was done to see how aging of specific organ may correlate with the development of diseases over two decades.
The study measured the biological age of nine key organs, including:
The researchers were able to find that different organs aged at different rates in different people. In many of the cases multiple organs showed signs of faster aging within the same individual. What is important to note is that those with accelerated aging in certain organs had a higher risk of developing 30 out of the 40 age-related diseases the study had tracked.
Some organ-disease connections were expected—people with rapidly aging lungs were more likely to develop respiratory diseases, and those with aging kidneys had an increased risk of kidney-related conditions. However, the study also found less obvious associations.
For example, individuals with fast-aging kidneys were more prone to diseases in other organs, such as the liver and pancreas. Additionally, multiple fast-aging organs were linked to an increased risk of kidney disease.
One of the most surprising findings was that dementia risk was not best predicted by an aging brain but rather by the immune system’s biological age. This suggests that factors such as chronic inflammation and immune health may play a critical role in neurodegenerative diseases.
The study also highlights the important of the potential of developing blood tests that could assess the biological age of specific organs. Unlike previous complex methods that measured the organ health, this new approach could make things simple to detect early signs of disease.
The leader author of the study Mika Kivimaki, who is also a professor at the University College London's Faculty of Brain sciences pointed out that such tests could be helpful when it comes to guiding personalized healthcare. In a news release, Kivimaki said, "They could advise whether a person needs to take better care of a particular organ and potentially provide an early warning signal that they may be at risk of a particular disease."
The study reinforces the idea that aging does not affect all organs equally and that looking beyond chronological age could offer better insights into disease prevention. By understanding which organs are aging more rapidly, medical professionals may be able to recommend targeted interventions for individuals at higher risk of specific conditions. Future advancements in organ-specific blood testing could revolutionize how we detect and manage age-related diseases, potentially leading to more personalized healthcare strategies.
Credits: Canva
According to the Indian Council of Medical Research - National Cancer Registry Programme (ICMR-NCRP), India reports about 220,000 new cases every year, and the common treatment procedure for this disease is chemotherapy, which comes with profound fatigue, hair loss, nausea, compromised immunity, and nerve damage.
The University College London led the Optima trial, which studied over 4000 patients with the disease in different parts of the world, and a low score on the genomic test could be mediated with only hormone therapy.
The trial’s chief investigator and a professor of breast oncology at UCL, Professor Rob Stein, explains that the study used tumour biology to guide decisions instead of relying on traditional clinical procedures.
The research had 4,429 women participants above the age of 40 years with hormone-positive breast cancer. These patients were then divided into two groups based on the genomic test results by the researchers, and one group with a higher risk was given chemotherapy along with hormone therapy, while the others were only treated with hormone therapy.
Breast cancer refers to the uncontrolled growth of the cells that are found along the inner lining of breast tissue. This out-of-control growth of cells leads to the formation of tumours. The tumour can be “invasive”, meaning that it spreads to the nearby tissues outside the breast, or “in situ”, where the tumour does not spread outside the breast region.
Usually, the “in situ” type of tumour is non-cancerous and non-life-threatening. However, in the case of invasive tumours, the cancerous cell mass can spread to the lymph nodes and further metastasise, that is, spread to other body parts. About 80% times the breast cancer cases are invasive. Hence, upon noticing symptoms like lumps, changes in breast shape, or abnormal nipple discharge, you must promptly consult a doctor.
While both men and women can develop it, in 99% of cases of breast cancer, women are seen to be affected by it. Only 0.5 to 1% of men are affected due to this condition. Furthermore, the condition is mostly prevalent in women aged 50 or older.
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After the advent of Ozempic-like drugs, the treatment of obesity has completely changed. Millions of people throughout the world use the medication either for obesity or diabetes. Although there were always concerns among medical professionals that the medication not only reduces fat but also lean muscle, which in turn leads to health loss, as muscle is very important to long-term health.
Now, a new study presented at the European Atherosclerosis Society (EAS) Congress 2026 claims that this vital minus point of the drug, causing lean fat loss, can be mended by pairing it with exercise. The study suggests that combining the drug with exercise can lead to better fat loss, while the muscle will also stay protected. Though the study was done on animals, further research on humans is required.
The researchers studied mice with obesity, insulin resistance, fatty liver disease, and atherosclerosis. The animals were divided into groups and given semaglutide. After 14 weeks, it was found that the drug alone reduced fat by 31 percent but also caused muscle loss, while when the medication was given with exercise, it caused fat loss by 45 percent, and lean mass loss was minimal.
The first thing to remember here is that Ozempic is a brand-name medicine that contains semaglutide as its active ingredient. Semglutide is the synthetic version of GLP-1, a natural hormone produced in the intestines that regulates blood sugar, appetite, and digestion. Now, every time you eat, your body produces various hormones, including GLP-1. These are called post-nutrition hormones and help you absorb the energy you just consumed.
GLP-1 travels to your pancreas, prompting it to produce insulin. It also travels to the hypothalamus in your brain, which gives you the feeling of being full or satiated. Ozempic imitates this hormone, thereby silencing the food chatter in the brain. Interestingly, for some people this food chatter is really quiet ( people with low appetite), and for others it is an outburst (people who generally binge eat). So with Ozempic, silencing this self-talk in the brain, people tend to lose their appetite and eventually weight.
However, it is important to note that losing weight includes not just fat but muscle as well. Losing too much muscle can lead to reduced strength and a shorter life span. Notably, records show that most people who start taking them stop them at 12 weeks; therefore, it is important for some but not for others.
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Ice cream is a sweet and delicious dessert loved and enjoyed by millions every day, and summers without this soothing treat are unimaginable, but some get a sharp stabbing pain after they have it. This headache is brain freeze, and it can reveal a lot about your health condition.
Amaal Starling, a neurologist at the Mayo Clinic in Minnesota, in the US, says, "Ice cream headache is very, very common." She added, "It's harmless, it comes, and it goes."
Scientists refer to brain freeze or ice cream headache as a cold-stimulus headache. According to the researchers, the reason for this condition is "rapid cooling at the roof of the mouth, or even in the very back of the throat". This cooling causes the blood vessels to shrink quickly after they return to their normal state. Which is the source of pain?
The research indicates that brain freeze seems to run in families. Though it also gets affected by your non-ice cream headaches, as people with migraines tend to feel far worse pain in brain freeze than others.
Stress Headaches
Stress headaches, also known as tension headaches, usually feel like a tight band squeezing your head. They are commonly caused by long working hours, lack of sleep, dehydration, or anxiety. However, these headaches generally go away with simple fixes, like rest, water, and relaxation techniques like yoga or meditation.
Migraines
Migraines often cause throbbing pain on one side of the head, along with nausea, vomiting, or sensitivity to light and sound. Some people also experience visual disturbances known as ‘auras’, flashes of light or zigzag patterns, before the headache even begins. They can last for hours or even days and may seriously impact the quality of life. Unlike stress headaches, migraines often need specific medication and lifestyle management.
Not every headache is about stress or migraines. Sometimes, a headache is a warning siren for something far more dangerous. Headaches can also indicate conditions such as high blood pressure, brain infections, stroke, or tumours. The red flags to look out for include:
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