A new study published in The Lancet Digital Health suggests that biological age of different organs could predict a person's risk of diseases such as cancer, dementia, and heart disease than their actual chronological age. The research analyzed long-term data from Whitehall II study, which had been followed by over 10,000 British adults for more than 35 years.

The blood plasma samples were collected between 1997 and 1999 from participants between ages 45 to 69. Researchers have now examined a follow up data from 6,235 participants, who were by then aged 65 to 89. This was done to see how aging of specific organ may correlate with the development of diseases over two decades.

What Organs Were Studied?

The study measured the biological age of nine key organs, including:

• Heart
• Blood vessels
• Liver
• Immune system
• Pancreas
• Kidneys
• Lungs
• Intestines
• Brain

The researchers were able to find that different organs aged at different rates in different people. In many of the cases multiple organs showed signs of faster aging within the same individual. What is important to note is that those with accelerated aging in certain organs had a higher risk of developing 30 out of the 40 age-related diseases the study had tracked.

Organ Aging And Disease Risk

Some organ-disease connections were expected—people with rapidly aging lungs were more likely to develop respiratory diseases, and those with aging kidneys had an increased risk of kidney-related conditions. However, the study also found less obvious associations.

For example, individuals with fast-aging kidneys were more prone to diseases in other organs, such as the liver and pancreas. Additionally, multiple fast-aging organs were linked to an increased risk of kidney disease.

One of the most surprising findings was that dementia risk was not best predicted by an aging brain but rather by the immune system’s biological age. This suggests that factors such as chronic inflammation and immune health may play a critical role in neurodegenerative diseases.

What Is Organ Specific Blood Tests?

The study also highlights the important of the potential of developing blood tests that could assess the biological age of specific organs. Unlike previous complex methods that measured the organ health, this new approach could make things simple to detect early signs of disease.

The leader author of the study Mika Kivimaki, who is also a professor at the University College London's Faculty of Brain sciences pointed out that such tests could be helpful when it comes to guiding personalized healthcare. In a news release, Kivimaki said, "They could advise whether a person needs to take better care of a particular organ and potentially provide an early warning signal that they may be at risk of a particular disease."

The study reinforces the idea that aging does not affect all organs equally and that looking beyond chronological age could offer better insights into disease prevention. By understanding which organs are aging more rapidly, medical professionals may be able to recommend targeted interventions for individuals at higher risk of specific conditions. Future advancements in organ-specific blood testing could revolutionize how we detect and manage age-related diseases, potentially leading to more personalized healthcare strategies.

A recent study suggests that a person’s blood group could play a role in whether they are more likely to develop severe liver conditions. Although most of us link blood type only with transfusions or donor matching, scientists now believe it may also offer clues about long-term liver health.

Higher Liver Disease Risk Linked to This Blood Group

A new study published in the journal Frontiers reports that individuals with blood group A have an increased chance of autoimmune liver disorders. In these conditions, the body’s own immune system mistakenly harms liver tissue, which can lead to ongoing damage and, in some cases, life-threatening liver failure.

The researchers also found that people with blood group B may have a slightly lower likelihood of certain liver-related concerns compared with those who have type A.

Why Your Blood Group Could Influence Liver Health?

Scientists have long examined how inherited blood groups relate to different illnesses. Some earlier findings noted that individuals with non-O blood types (A, B, or AB) tend to show higher activity of certain clotting factors and other changes in the body.

These differences may affect blood flow in the liver. For example, past studies found slightly increased levels of a clotting protein called von Willebrand factor in people with advanced liver disease who had non-O blood types, although it does not appear to be a major driver of risk.

Liver Conditions Connected to Certain Blood Groups

The latest research focused on autoimmune liver diseases such as:

• Autoimmune hepatitis, in which the immune system attacks liver cells.
• Primary biliary cholangitis (PBC), where the bile ducts inside the liver slowly break down.

Among these, autoimmune hepatitis showed a stronger link with blood group A. Blood group B appeared to carry a somewhat lower chance of PBC when compared with type A.

What Past Research Shows About Liver Cancer

Several earlier studies explored the relationship between blood group and liver cancer (hepatocellular carcinoma or HCC). Older data and a large meta-analysis found that people with type O blood were under-represented among those with liver cancer, suggesting that type O may be tied to a lower risk overall.

Why Knowing Your Blood Type Helps

Understanding your blood group can offer insight into potential health risks, though it does not mean you will certainly develop liver disease if you are type A or B. It remains only one part of a larger picture.

This may be especially important if you have blood type A or B and a family history of liver conditions. Routine health checks, liver screenings, and discussions with your doctor can help you watch for any early signs.

For now, it is clear that blood type is more than a simple classification, as it may hold useful information about future liver health.

Autoimmune liver disorders are uncommon, yet they can become serious when they are not spotted in time. A better grasp of the genetic and immune-related factors behind them can guide stronger prevention and treatment efforts. The authors of the study note that more research involving larger and more varied groups of people is needed to confirm these findings and to explain how different ABO blood types may influence the development of autoimmune liver problems.

According to the International Diabetes Federation, roughly one in nine adults worldwide lives with diabetes, and around 90% of these cases are type 2 diabetes. There is currently no cure for type 2 diabetes. Still, the condition can be managed through healthy lifestyle habits, such as staying active, as well as medication. One widely used medication is metformin, considered a first-line therapy for type 2 diabetes, and it has been prescribed for decades since the Food and Drug Administration (FDA) approved it in 1994. Recent research, however, suggests it may also act directly on the brain, opening the door to new approaches to treatment.

Metformin Found to Unexpectedly Affect The Brain

Scientists at Baylor College of Medicine in the US have discovered a brain pathway that metformin appears to influence, alongside its known effects on other parts of the body. "It has been widely believed that metformin lowers blood sugar mainly by reducing glucose production in the liver. Other studies have also highlighted its action in the gut," says Makoto Fukuda, a pathophysiologist at Baylor.

As reported by Science Alert, the researchers explained, "We turned our attention to the brain, given its central role in regulating overall glucose metabolism. Our goal was to understand whether and how the brain contributes to metformin’s anti-diabetic effects."

How Is Metformin Affecting Your Brain?

Earlier research by some of the same scientists had pinpointed a protein in the brain called Rap1, which influences glucose metabolism, especially in a region called the ventromedial hypothalamus (VMH).

In their 2025 study, experiments on mice showed that metformin reaches the VMH, where it helps combat type 2 diabetes by essentially shutting down Rap1. When mice were genetically modified to lack Rap1, metformin no longer affected a diabetes-like condition—even though other medications still worked. This provides strong evidence that metformin acts in the brain through a mechanism distinct from other drugs.

The researchers also examined which specific neurons metformin interacts with. This could eventually pave the way for treatments that target these neurons directly. "We found that SF1 neurons are activated when metformin enters the brain, indicating they are directly involved in the drug’s effect," they said.

Metformin Side Effects

While generally safer than many other type 2 diabetes medications, metformin does have side effects. Gastrointestinal issues such as nausea, diarrhea, and stomach discomfort affect up to 75% of users. Other risks can arise when there are underlying conditions like kidney problems, which may compound health concerns.

Metformin is also recognized as a gerotherapeutic—a medication that may slow aging processes in the body. For instance, it has been shown to reduce DNA damage and support gene activity linked to longer life.

Previous studies indicate that metformin can also protect the brain from wear and tear and may even lower the risk of long COVID, according to Science Direct.

Delhi NCR is already facing one of its toughest air-quality crises, and now another worry has emerged. Volcanic ash from Ethiopia’s Hayli Gubbi volcano has started drifting toward Indian skies. BBC reports that ash clouds from this rare eruption have reached Delhi, raising concerns about health risks in a city where clean air is already hard to come by due to rising pollution. As this volcanic ash moves closer, people fear it could worsen existing respiratory problems.

In Delhi, where the Air Quality Index (AQI) often falls in the “very poor” or “severe” range, even small increases in particulate matter can have serious health effects. Understanding what volcanic ash can do and taking the right precautions can help reduce its impact.

Ethiopian Volcanic Ash Reaches Delhi

A volcano in northern Ethiopia erupted on Sunday for the first time in nearly 12,000 years. Winds blowing at 100–120 km/h carried ash plumes to several countries. The Hayli Gubbi volcano in Ethiopia’s Afar region erupted Sunday morning, and by late last night, ash clouds reached Delhi, which is already struggling with toxic air, causing some disruption to flights.

The ash plumes, rising thousands of feet into the atmosphere, first passed over Gujarat and then moved toward Rajasthan, Delhi, Haryana, and Punjab. According to the India Meteorological Department (IMD), the ash clouds are drifting toward China and are expected to clear from Indian skies by 7:30 pm.

The Health Impact Of Volcanic Ash: What Science Says

Volcanic smog, also called “vog,” is generated whenever a volcano erupts. Global health bodies like the World Health Organization (WHO) and the US Centers for Disease Control and Prevention (CDC) have long studied its effects. Here’s what you need to know about how volcanic ash can impact health.

Respiratory Risks: Who’s Most Vulnerable

Volcanic ash is made of fine particles that can reach deep into the lungs. According to the US Geological Survey’s Impacts & Mitigation guidelines, inhaling these particles can lead to:

• Irritation of the nose, throat, and upper airways
• Dry cough, sore throat, or chest discomfort
• Bronchitis-like symptoms or wheezing in people with asthma or chronic bronchitis

Even healthy individuals may experience shortness of breath or discomfort after heavy exposure. For those with pre-existing lung conditions, the effects can be much more serious.

Ethiopia’s Volcanic Ash: What Is Delhi’s Situation?

IMD Director General M. Mohapatra stated that the plume is approaching Delhi NCR, but “any significant impact on ground-level pollution is unlikely” because most of the ash is high in the atmosphere. He added that the ash cloud may appear as a cloudy, hazy sky for a few hours as it moves eastwards.

Meteorologists and weather analysts have noted that the plume contains volcanic ash, sulphur dioxide, and tiny glass or rock particles. It is moving quickly, at around 100–200 km/h, according to reports.

Can Ethiopia’s Volcanic Ash Make Delhi Respiratory Issues More Dangerous?

Dr Aditya Nag, Assistant Professor, Department of Respiratory Medicine, NIIMS Medical College and Hospital, told us that even if most of the ash remains high in the sky, fine particles can settle on the ground and mix with Delhi’s already polluted air. Components like ash and sulphur dioxide can irritate the lungs, throat, and eyes.

Dr. Manav Manchanda, Director & Head – Respiratory, Critical Care & Sleep Medicine, Asian Hospital, told us that people most at risk include children, the elderly, and anyone with asthma or COPD. Volcanic ash can also pose environmental risks, such as reducing visibility or damaging engines.

“Abrasive particles in the volcanic ash can trigger bronchospasm in COPD and asthma patients, making their condition worse,” said Dr Aditya Nag.

Precautions To Stay Safe

Dr. Manav Manchanda, advise the same safety measures that apply during high pollution days:

• Wear N95 or N99 masks outdoors: These filter fine ash particles better than regular masks.
• Limit outdoor activities during peak pollution: Avoid exercising in the morning or late evening.
• Keep doors and windows closed: Use an air purifier to reduce indoor air contamination.
• Stay hydrated: Drink warm water or herbal teas to help clear your lungs.
• Steam inhalation: Regular steam can help remove small particles trapped in the nasal passages and airways.
• Eat health-supportive foods: Include ginger, turmeric, tulsi, citrus fruits, and honey to support respiratory health.
• Keep medicines handy: Asthma patients or those with chronic lung conditions should have doctor-prescribed medications ready.