A new study published in The Lancet Digital Health suggests that biological age of different organs could predict a person's risk of diseases such as cancer, dementia, and heart disease than their actual chronological age. The research analyzed long-term data from Whitehall II study, which had been followed by over 10,000 British adults for more than 35 years.

The blood plasma samples were collected between 1997 and 1999 from participants between ages 45 to 69. Researchers have now examined a follow up data from 6,235 participants, who were by then aged 65 to 89. This was done to see how aging of specific organ may correlate with the development of diseases over two decades.

What Organs Were Studied?

The study measured the biological age of nine key organs, including:

• Heart
• Blood vessels
• Liver
• Immune system
• Pancreas
• Kidneys
• Lungs
• Intestines
• Brain

The researchers were able to find that different organs aged at different rates in different people. In many of the cases multiple organs showed signs of faster aging within the same individual. What is important to note is that those with accelerated aging in certain organs had a higher risk of developing 30 out of the 40 age-related diseases the study had tracked.

Organ Aging And Disease Risk

Some organ-disease connections were expected—people with rapidly aging lungs were more likely to develop respiratory diseases, and those with aging kidneys had an increased risk of kidney-related conditions. However, the study also found less obvious associations.

For example, individuals with fast-aging kidneys were more prone to diseases in other organs, such as the liver and pancreas. Additionally, multiple fast-aging organs were linked to an increased risk of kidney disease.

One of the most surprising findings was that dementia risk was not best predicted by an aging brain but rather by the immune system’s biological age. This suggests that factors such as chronic inflammation and immune health may play a critical role in neurodegenerative diseases.

What Is Organ Specific Blood Tests?

The study also highlights the important of the potential of developing blood tests that could assess the biological age of specific organs. Unlike previous complex methods that measured the organ health, this new approach could make things simple to detect early signs of disease.

The leader author of the study Mika Kivimaki, who is also a professor at the University College London's Faculty of Brain sciences pointed out that such tests could be helpful when it comes to guiding personalized healthcare. In a news release, Kivimaki said, "They could advise whether a person needs to take better care of a particular organ and potentially provide an early warning signal that they may be at risk of a particular disease."

The study reinforces the idea that aging does not affect all organs equally and that looking beyond chronological age could offer better insights into disease prevention. By understanding which organs are aging more rapidly, medical professionals may be able to recommend targeted interventions for individuals at higher risk of specific conditions. Future advancements in organ-specific blood testing could revolutionize how we detect and manage age-related diseases, potentially leading to more personalized healthcare strategies.

It was during the COVID-19 pandemic that Annabelle Gurwitch, an American author, actress, and television host, developed a "a little persistent cough".

Suspecting it to be a COVID symptom, Annabelle went for a check-up. Her doctor alarmingly informed her about something suspicious on her lungs. Soon after, an X-ray and a biopsy confirmed her diagnosis of stage 4 cancer.

But, here's the catch. Annabelle is a non-smoker. She also lived a healthy lifestyle and exercised every day, and felt like she was in really good health, besides the persistent little cough.

Also read:American Author Annabelle Gurwitch Writes New Memoir On Stage-4 Lung Cancer Diagnosis

HealthandMe spoke to health experts to understand how a persistent cough signals the risk of lung cancer.

If you, too, are a non-smoker who is leading a healthy lifestyle and has no medical conditions other than a persistent cough, then you must visit your doctor right away, advised the experts.

"A persistent cough can be an early warning sign of lung cancer, especially when it shows specific features rather than behaving like a routine respiratory illness," Dr Sameer Khatri, Principal Director - Medical Oncology, Max Super Speciality Hospital, Patparganj, told HealthandMe.

The doctor noted that the cough becomes suspicious when it persists beyond three weeks without a clear cause or fails to respond to standard symptomatic treatment such as cough syrups, bronchodilators, etc.

"A change in a pre-existing smoker’s cough—for example, becoming more frequent, severe, or different in character—is particularly important. In non-smokers, a new, unexplained chronic cough should not be ignored," Dr. Khatri said.

Certain associated symptoms further strengthen the suspicion of cancer. The most significant is hemoptysis, the coughing up of blood or blood-stained mucus, even if minimal.

Other red flags include

• unintentional weight loss,
• chest pain,
• breathlessness,
• hoarseness,
• recurrent pneumonia in the same lung region.
• age >40 years,
• smoking history, occupational exposures.

Persistent cough: TB Vs Lung Cancer

Persistent cough also signals the risk of tuberculosis (TB) -- the world's most deadliest infectious disease. Understanding the differences between these two causes is critical for early diagnosis and timely treatment.

Dr Seema Jagiasi from MOC Cancer Care Center told HealthandMe that the cough in TB may sometimes produce blood-tinged phlegm, but it is usually associated with signs of infection, such as fatigue and a general feeling of illness.

TB is more common in younger populations and in individuals with weakened immunity or poor living conditions.

"In contrast, a cough associated with lung cancer tends to be more insidious. It may start as a dry, persistent cough that gradually worsens over time. Unlike TB, it may not initially present with fever or infection-related symptoms," the doctor explained.

Also read: Suffering From Mid-back Pain? Doctors Say It May Be Spinal TB

One of the key differences lies in progression and response to treatment.

TB is treatable with a course of antibiotics, and symptoms often improve within weeks of starting therapy. However, a lung cancer-related cough persists or worsens despite routine medications.

Dr Jagiasi emphasized that any cough lasting beyond three weeks, especially when accompanied by alarming symptoms, should not be ignored.

"Early investigations, such as chest imaging and further diagnostic tests, can help distinguish between the two conditions," the doctor said.

While both TB and lung cancer may present with a persistent cough, their underlying causes, associated symptoms, and progression differ significantly.

The health experts called for more awareness and the need for timely medical evaluation for the effective management of the disease.

Irish Actor Michael Patrick, known for his significant role in Game of Thrones, has sadly passed away at the young age of 35.

Sharing the news in a post on social media platform Instagram, his wife Naomi Sheehan shared that Michael Patrick (whom she fondly calls Mick) died after a years-long battle with Motor Neurone Disease.

"Last night, Mick sadly passed away in the Northern Ireland Hospice. He was diagnosed with Motor Neurone Disease on 1st February 2023. He was admitted 10 days ago and was cared for by the incredible team there. He passed peacefully, surrounded by family and friends," Naomi said.

Calling Michael a "titan of a ginger-haired man", she said that “Words can’t describe how broken-hearted we are".

Naomi called Michael an "inspiration to everyone."

Also read: Dismissed as Anxiety: Terry Crew’s Wife Rebecca Shares Decade-Long Struggle With Parkinson’s

What Is Motor Neurone Disease (MND)

MND is a rare and progressive neurodegenerative disease. According to NHS UK, it causes muscle weakness that gets worse over a few months or years. It's usually life-shortening, and there's currently no cure, but treatment can help manage the symptoms.

Symptoms of MND include:

• stiff or weak hands
• weak legs and feet
• twitches, spasms, or muscle cramps (where muscles painfully tighten).

It makes everyday tasks such as climbing stairs or gripping objects difficult.

Also read: Grey’s Anatomy Star Eric Dane Dies After ALS Battle

As the disease advances, patients may develop difficulties with breathing, swallowing, and speech, along with changes in mood or personality. In later stages, walking and movement can become extremely limited.

Treatment of MND

About 1,500 people are diagnosed with MND each year, yet treatment choices remain scarce. Only a small proportion of patients currently qualify for therapies that target the disease process itself.

MND can be difficult to diagnose in the early stages. But as the symptoms get worse, it can usually be confirmed.

Tests used to help diagnose MND include:

• blood tests
• tests to check how well your nerves are working
• an MRI scan to help rule out other conditions that affect the brain and nerves

1. Amyotrophic lateral sclerosis (ALS): Early symptoms include muscle weakness in the arms and legs can cause you to trip and drop things.

2. Progressive bulbar palsy (PBP): It mainly affects muscles in the face, throat, and tongue, causing slurred speech and problems swallowing.

3. Progressive muscular atrophy (PMA): It causes weakness in the hands.

4. Primary lateral sclerosis (PLS): Leads to weak legs, sometimes with other symptoms, including speech problems.

Common treatment options for MND include:

• physiotherapy and exercises to help with muscle weakness and stiffness
• dietary advice to help you maintain weight
• speech and language therapist to help with talking
• Cognitive behavioral therapy (CBT) to help cope with emotions and feelings, such as anxiety and depression.

During the COVID-19 pandemic, the SARS-CoV-2 virus had a significant impact on the eyes, causing conjunctivitis (pink eye), with red, itchy, watery, or painful eyes.

A new study now shows that eye symptoms may also be key in understanding the severity of long COVID, a collection of symptoms that last three months or longer after your first COVID symptoms.

The new study, published in the journal Clinical Ophthalmology, showed that the new onset of eye symptoms in people with long COVID may be an indicator of more severe disease.

Also read: Long Covid Causes Lasting Brain Inflammation And Lung Injury, Reveals Study

Key Findings

Researchers from the Yale School of Medicine analyzed survey data from 595 adults who self-reported having long COVID in surveys conducted from May 2022 to October 2023. They found that nearly 60 percent of people reported new-onset of ocular symptoms.

The findings suggest that ocular symptoms in long COVID may be interpreted as vision-related manifestations that cluster with systemic post-COVID conditions. The symptoms include a new onset of :

• blurred or lost vision,
• dry eyes,
• floaters or flashes

Notably, individuals with ocular symptoms reported:

• A greater overall symptom burden,
• Financial difficulties,
• Challenges in everyday life.

Also read: Long COVID: The Story Of Those Who Are Still Dealing With Symptoms And Illnesses

What is Long COVID

Long COVID includes a wide range of symptoms or conditions that may improve, worsen, or be ongoing. While anyone who gets COVID-19 can develop Long COVID, studies have shown that some groups of people are more likely to develop Long COVID than others, including:

• Women
• People who have experienced more severe COVID-19 illness, especially those who were hospitalized or needed intensive care
• People with underlying health conditions
• People who did not get a COVID-19 vaccine

While many of the Long COVID conditions remain to be fully recognized, some people have more than one symptom that can be moderate to severe, and also impact the quality of life. According to the US CDC, they include:

• Tiredness or fatigue
• Difficulty thinking or concentrating (sometimes called “brain fog”)
• Shortness of breath or difficulty breathing
• Headache
• Dizziness on standing
• Fast-beating or pounding heart (known as heart palpitations)
• Chest pain
• Cough
• Joint or muscle pain
• Depression or anxiety
• Fever
• Loss of taste or smell