Your body hosts trillions of bacteria, viruses, and fungi, collectively known as the microbiome. While some bacteria are linked to disease, many play essential roles in supporting your immune system, heart health, weight management, and overall well-being. This article delves into the significance of the gut microbiome and its impact on health.

What Is Gut Microbiome?

Interestingly, bacterial cells outnumber human cells in the body, with approximately 40 trillion bacterial cells compared to 30 trillion human cells. With up to 1,000 species of bacteria present in the gut, each plays a distinct role. While most bacteria contribute positively to health, some can be harmful. Together, these microbes weigh around 1–2 kilograms, functioning almost like an additional organ essential for overall well-being.

How Does Gut Microbiome Influence Your Health?

The relationship between humans and microbes has evolved over millions of years, with the gut microbiome playing a crucial role from birth. Initial exposure to microbes occurs during birth, and some evidence suggests that exposure begins in the womb. As the microbiome diversifies, it starts influencing key bodily functions:

Digestion of breast milk: Beneficial bacteria like Bifidobacteria help break down essential sugars in breast milk, supporting infant growth.

Fiber digestion: Some bacteria process fiber into short-chain fatty acids, which contribute to gut health and reduce risks of obesity, diabetes, and heart disease.

Immune system regulation: The gut microbiome interacts with immune cells, influencing how the body responds to infections.

Brain health: Emerging research suggests a link between the gut microbiome and brain function, potentially affecting mental health and neurological processes.

Gut Microbiome And Weight Management

An imbalance between beneficial and harmful microbes, known as gut dysbiosis, may contribute to weight gain. Studies on identical twins—one with obesity and the other without—suggest that microbiome composition plays a role in body weight independent of genetics. Additionally, animal studies indicate that gut bacteria can influence weight gain, even when calorie intake remains constant.

Probiotics, beneficial bacteria found in supplements and certain foods, can help restore gut balance and support weight loss, though their effects may be modest.

Gut Health And Disease Prevention

The gut microbiome plays a vital role in preventing and managing conditions like irritable bowel syndrome (IBS) and inflammatory bowel disease (IBD). Imbalances in gut bacteria may lead to bloating, cramps, and digestive issues. On the other hand, beneficial bacteria like Bifidobacteria and Lactobacilli help strengthen the intestinal lining, reducing the risk of gut-related disorders.

Impact On Heart Health

Research suggests that the gut microbiome influences heart health by affecting cholesterol levels and blood pressure. Certain harmful bacteria produce trimethylamine N-oxide (TMAO), a compound linked to blocked arteries and heart disease. However, probiotics, particularly those containing Lactobacilli, may help reduce cholesterol levels and promote cardiovascular health.

Blood Sugar Regulation And Diabetes Risk

The gut microbiome also plays a role in regulating blood sugar levels. Research on infants genetically predisposed to type 1 diabetes indicates that gut microbiome diversity declines before disease onset. Furthermore, individual variations in gut bacteria may explain why people experience different blood sugar responses to the same foods.

Connection Between Gut And Brain

The gut is physically connected to the brain through nerves, and certain bacteria help produce neurotransmitters like serotonin, which influence mood and mental health. Studies indicate that people with mental health disorders often have different gut bacteria compared to those without such conditions. Additionally, some probiotics have shown promise in alleviating symptoms of depression and anxiety.

Tips For Healthier Gut Microbiome

Maintaining a balanced gut microbiome is crucial for overall health. Here are some strategies to support gut health:

• Eat a diverse range of foods: A varied diet rich in fiber, legumes, and fruits promotes microbial diversity.
• Consume fermented foods: Yogurt, kefir, and sauerkraut contain probiotics that enhance gut health.
• Limit artificial sweeteners: Some artificial sweeteners can encourage the growth of harmful bacteria.
• Include prebiotic foods: Bananas, oats, and asparagus contain fibers that nourish beneficial bacteria.
• Breastfeed infants when possible: Breastfeeding promotes a healthier gut microbiome in babies.
• Choose whole grains: Whole grains contain fiber and beneficial compounds that support digestive health.
• Opt for a plant-based diet: Vegetarian diets may reduce inflammation and support a healthier gut microbiome.
• Consume polyphenol-rich foods: Green tea, dark chocolate, and olive oil contain compounds that foster beneficial bacteria.
• Take probiotics if needed: Probiotic supplements can help restore gut balance after disruptions, such as antibiotic use.
• Use antibiotics cautiously: While antibiotics can be life-saving, overuse can harm beneficial gut bacteria.

The IVF laboratory is a critical place where science and precision come together to help create embryos. Here, the expert explains the careful measures that take place inside the lab and the important role of the embryologist in helping couples achieve parenthood.

Many couples are battling infertility and are advised to undergo in vitro fertilization (IVF) to conceive. The couples tend to focus on various factors such as doctor consultations, hormone injections, and embryo transfer.

However, one of the most important parts of the treatment happens in the IVF laboratory. Couples are often unaware of what happens behind the closed doors in the IVF lab.

The IVF Lab: A Highly Controlled Environment

Did you know? Highly trained embryologists work with advanced technology when it comes to handling the eggs, sperm, and embryos in the IVF laboratory.

They are the ones who are responsible for planning and carrying out every step with accuracy to be able to give embryos the best possible environment for healthy development.

The lab is a controlled and sterile space wherein the temperature, humidity, air quality, and lighting are strictly monitored to be able to protect the delicate eggs and embryos.

Even small changes in the environment tend to impact embryo development, so strict quality standards are followed every day by the expert.

Also read: From Hope To Parenthood: How IVF And Embryology Are Changing The Fertility Journey For Couples

From Egg Retrieval to Fertilisation

The process commences after the woman's eggs are collected during a minor procedure. On the same day, the male partner will also provide a semen sample, or previously frozen sperm, if needed. The embryologist will examine both the eggs and sperm under a microscope to check the quality.

Then the healthiest sperm are selected to fertilise the eggs.

Fertilisation will occur after the egg and the sperm are placed together in a special culture dish or via a procedure known as Intracytoplasmic Sperm Injection (ICSI), wherein a single healthy sperm is directly injected into the egg.

The expert will decide the method after knowing the couple's fertility condition.

Also read: Delhi's Poor AQI, Monsoon Conditions Put Children's Lungs at Risk: Ways to Keep Kids Safe

Monitoring Embryo Development

When fertilisation happens, the embryos are placed in special incubators that closely mimic the conditions inside the human body.

Over the next few days, embryologists monitor their growth and development, and some embryos may undergo genetic testing to identify certain inherited or chromosomal conditions before they are transferred.

The Embryologist's Role in Ensuring Safety and Success

Understand that the embryologist maintains detailed records and follows strict identification protocols to ensure every egg, sperm, and embryo is accurately matched with the correct patient.

Hence, the embryologist plays a vital role in every successful IVF journey.

Ravi is 34 years old. He goes to the gym three times a week, weighs a healthy 68 kg, and has never been diagnosed with diabetes or high blood pressure. During his company's annual health check-up, an ultrasound revealed four unexpected words: Grade 1 Fatty Liver.

Like many people, Ravi was shocked. "How is that possible?" he asked. "I'm not overweight."

The answer reflects a growing reality that is changing how liver specialists understand one of India's fastest-growing liver diseases.

The Old Story Vs The New Reality

For years, fatty liver—now medically known as Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD)—was considered a condition affecting people who were overweight, had diabetes, or consumed excessive alcohol.

That understanding is no longer complete.

Today, we increasingly diagnose fatty liver in individuals who are lean, appear metabolically healthy, and do not consume alcohol. This condition, often referred to as lean MASLD, accounts for nearly 10–20% of fatty liver cases in Asia. Given the unique genetic and metabolic profile of South Asians, the true burden in India may be even higher.

So, What Is Actually Going On? The reasons are more complex than body weight alone—and many are hiding in plain sight.

Also read: Do People With Type 2 Diabetes Face A Higher Risk of Severe Dengue? New Review Says Yes

Your Genes May Be Working Against You

Certain genetic variants, particularly PNPLA3, make the liver more likely to store fat even when the rest of the body appears healthy. This genetic predisposition is significantly more common among South Asians than Western populations.

In other words, you may be lean, eat reasonably well, and still develop fatty liver because of your inherited biology.

Hidden Metabolic Dysfunction

A normal body weight does not always mean a healthy metabolism.

Many lean Indians carry excess visceral fat—fat stored around internal organs rather than under the skin. This "skinny fat" phenomenon is especially common in our population and is strongly linked to liver fat accumulation and inflammation, despite a normal BMI.

Also read: Subtle Warning Signs Of Serious Health Conditions That Only Your Partner Can Notice

It's Not Just How Much You Eat — It's What You Eat

A diet rich in refined carbohydrates and added sugars can overwhelm the liver.

Frequent consumption of foods such as white rice, refined flour (maida), packaged snacks, biscuits, sugary beverages, and fruit juices provides excess fructose, which the liver converts directly into fat.

Over time, this process promotes fatty liver—even in individuals who never become overweight.

By Dr. Chetan Kalal, DM Hepatology, Liver Transplant Specialist, Saifee Hospital, Mumbai

For most people, dengue is associated with high fever, severe body aches, headache, fatigue, and a temporary drop in platelet count. With proper care, the majority of patients recover completely within a couple of weeks. However, doctors caution that in rare instances, dengue can leave behind an unexpected complication that affects the nervous system rather than the blood—Guillain-Barre syndrome (GBS).

What Is Guillain-Barre Syndrome (GBS)?

GBS is an uncommon autoimmune disorder in which the body's immune system mistakenly attacks the peripheral nerves. It usually develops after an infection, and growing evidence suggests that dengue can be one of the infections capable of triggering this immune response. While the chances remain low, the condition can progress rapidly and requires prompt medical attention.

The condition affects the nerves and can cause increasing weakness in the legs, arms, face and swallowing.

Also read: Do People With Type 2 Diabetes Face A Higher Risk of Severe Dengue? New Review Says Yes

How Dengue Can Trigger GBS

Unlike the fever and body pain seen during active dengue infection, GBS often appears days or even weeks after the patient seems to be recovering. This delay can make it easy to overlook the connection.

Our immune system protects our body by fighting infections. In some rare cases an infection like dengue can trigger a strange immune response where our body mistakenly attacks its own nerves.

Nerves carry signals between our brain and the rest of our body allowing us to move and feel normally. When nerves get damaged it disrupts the signals from our brain leading to muscle weakness tingling and other symptoms.

Someone who has recently recovered from dengue may suddenly notice tingling in the feet or hands, weakness in the legs, difficulty climbing stairs, or an unsteady walk. As the condition progresses, the weakness may spread upwards, affecting the arms, facial muscles, swallowing, or even the muscles responsible for breathing.

The exact reason this happens is believed to be an abnormal immune response. Instead of switching off after fighting the dengue virus, the immune system mistakenly attacks the protective covering of the nerves, disrupting the signals between the brain and muscles. This results in the characteristic muscle weakness seen in GBS.

Guillain-Barre syndrome usually develops when we are recovering from dengue or even days to weeks after the fever has gone away.

Also read: India’s First Approved Dengue Vaccine: Takeda’s QDENGA Protects Against All Four Virus Serotypes

Warning Signs You Should Not Ignore

Feeling tired and fatigued is common, after dengue. Usually gets better slowly. However, we need to differentiate it from weakness. Neurological weakness means our muscle movements are affected.

It often starts in our legs. We may notice it is getting harder to climb stairs get up from a chair or walk normally. This weakness can sometimes spread to our arms and face. In cases it can even affect our swallowing or breathing which may require ICU and ventilator support.

Although dengue-related GBS is rare, recognising the warning signs early can make a significant difference. Timely diagnosis and treatment can help reduce complications and improve recovery.

Any person who develops new weakness, numbness, difficulty walking, facial drooping, trouble swallowing, or breathlessness in the weeks following dengue should seek immediate medical evaluation rather than assuming it is part of normal post-viral fatigue.

Also read: Will Waterborne Diseases Rise In The Future? New Study Says Climate Change Could Be A Major Driver

Why Early Recognition Matters

The reassuring news is that most people with dengue will never develop Guillain-Barre syndrome. Nevertheless, awareness remains important because the condition can become serious if left untreated.

Preventing mosquito bites, eliminating stagnant water around homes, and seeking medical care early for suspected dengue remain the best ways to reduce the risk of both the infection and its uncommon complications.

The main thing to remember this monsoon is simple: feeling tired after dengue's normal but if our weakness is getting worse we should not ignore it. Recognizing this difference. Getting medical help early can help us identify this rare but treatable complication on time.

As dengue cases rise during the monsoon, recovery should not simply be measured by the disappearance of fever. Paying attention to new neurological symptoms after the illness has resolved can help ensure that a rare but potentially life-threatening complication is recognised before it becomes an emergency.

By Dr. Abizer Manked, Consultant Physician and Diabetologist at Saifee Hospital, Mumbai and Dr. Arun Shah, Director Neurosciences, Sir HN Reliance Foundation Hospital, Mumbai