Your body hosts trillions of bacteria, viruses, and fungi, collectively known as the microbiome. While some bacteria are linked to disease, many play essential roles in supporting your immune system, heart health, weight management, and overall well-being. This article delves into the significance of the gut microbiome and its impact on health.

What Is Gut Microbiome?

Interestingly, bacterial cells outnumber human cells in the body, with approximately 40 trillion bacterial cells compared to 30 trillion human cells. With up to 1,000 species of bacteria present in the gut, each plays a distinct role. While most bacteria contribute positively to health, some can be harmful. Together, these microbes weigh around 1–2 kilograms, functioning almost like an additional organ essential for overall well-being.

How Does Gut Microbiome Influence Your Health?

The relationship between humans and microbes has evolved over millions of years, with the gut microbiome playing a crucial role from birth. Initial exposure to microbes occurs during birth, and some evidence suggests that exposure begins in the womb. As the microbiome diversifies, it starts influencing key bodily functions:

Digestion of breast milk: Beneficial bacteria like Bifidobacteria help break down essential sugars in breast milk, supporting infant growth.

Fiber digestion: Some bacteria process fiber into short-chain fatty acids, which contribute to gut health and reduce risks of obesity, diabetes, and heart disease.

Immune system regulation: The gut microbiome interacts with immune cells, influencing how the body responds to infections.

Brain health: Emerging research suggests a link between the gut microbiome and brain function, potentially affecting mental health and neurological processes.

Gut Microbiome And Weight Management

An imbalance between beneficial and harmful microbes, known as gut dysbiosis, may contribute to weight gain. Studies on identical twins—one with obesity and the other without—suggest that microbiome composition plays a role in body weight independent of genetics. Additionally, animal studies indicate that gut bacteria can influence weight gain, even when calorie intake remains constant.

Probiotics, beneficial bacteria found in supplements and certain foods, can help restore gut balance and support weight loss, though their effects may be modest.

Gut Health And Disease Prevention

The gut microbiome plays a vital role in preventing and managing conditions like irritable bowel syndrome (IBS) and inflammatory bowel disease (IBD). Imbalances in gut bacteria may lead to bloating, cramps, and digestive issues. On the other hand, beneficial bacteria like Bifidobacteria and Lactobacilli help strengthen the intestinal lining, reducing the risk of gut-related disorders.

Impact On Heart Health

Research suggests that the gut microbiome influences heart health by affecting cholesterol levels and blood pressure. Certain harmful bacteria produce trimethylamine N-oxide (TMAO), a compound linked to blocked arteries and heart disease. However, probiotics, particularly those containing Lactobacilli, may help reduce cholesterol levels and promote cardiovascular health.

Blood Sugar Regulation And Diabetes Risk

The gut microbiome also plays a role in regulating blood sugar levels. Research on infants genetically predisposed to type 1 diabetes indicates that gut microbiome diversity declines before disease onset. Furthermore, individual variations in gut bacteria may explain why people experience different blood sugar responses to the same foods.

Connection Between Gut And Brain

The gut is physically connected to the brain through nerves, and certain bacteria help produce neurotransmitters like serotonin, which influence mood and mental health. Studies indicate that people with mental health disorders often have different gut bacteria compared to those without such conditions. Additionally, some probiotics have shown promise in alleviating symptoms of depression and anxiety.

Tips For Healthier Gut Microbiome

Maintaining a balanced gut microbiome is crucial for overall health. Here are some strategies to support gut health:

• Eat a diverse range of foods: A varied diet rich in fiber, legumes, and fruits promotes microbial diversity.
• Consume fermented foods: Yogurt, kefir, and sauerkraut contain probiotics that enhance gut health.
• Limit artificial sweeteners: Some artificial sweeteners can encourage the growth of harmful bacteria.
• Include prebiotic foods: Bananas, oats, and asparagus contain fibers that nourish beneficial bacteria.
• Breastfeed infants when possible: Breastfeeding promotes a healthier gut microbiome in babies.
• Choose whole grains: Whole grains contain fiber and beneficial compounds that support digestive health.
• Opt for a plant-based diet: Vegetarian diets may reduce inflammation and support a healthier gut microbiome.
• Consume polyphenol-rich foods: Green tea, dark chocolate, and olive oil contain compounds that foster beneficial bacteria.
• Take probiotics if needed: Probiotic supplements can help restore gut balance after disruptions, such as antibiotic use.
• Use antibiotics cautiously: While antibiotics can be life-saving, overuse can harm beneficial gut bacteria.

The U-WIN (Universal Immunization Win) platform has been transformative and has helped India tackle the concerning burden of zero-dose children, said Dr NK Arora, an immunization expert and member of the National Technical Advisory Group on Immunisation in India (NTAGI).

In an exclusive conversation with HealthandMe during World Immunization Week 2026, Dr Arora, Executive Director of The INCLEN Trust International, traced the journey of the U-WIN portal and explained how it has strengthened vaccine uptake in the country.

U-WIN is a digital platform and app to help people find vaccination centers near their residences, manage vaccination appointments at health facilities, and maintain vaccination records.

Dr Arora noted that the U-WIN portal created a digital ecosystem that played a critical role in registration, appointment scheduling, vaccine tracking, and real-time monitoring.

The Origin Of U-WIN

U-Win was launched in October 2024 and is available in 12 languages, including English.

Dr Arora, also the chair of the COVID-19 and HPV vaccine working group, shared that during the deadly COVID pandemic in 2020—around July—it became very clear that to vaccinate 140 crore people, some kind of IT platform is needed that will track individuals who had been vaccinated, especially when they needed their second dose, and later, booster doses.

“Everything started somewhere around July 2020, and by January 2021, we had the Co-WIN platform. By mid-April, things were streamlined. The platform gives us a long list of individuals who have been vaccinated. It also helps to know who has been left out of the vaccination.

“It is like a registry of human beings who are getting immunized. And we could send reminders, we could send certificates, and we can also tell the individual when to get their second and third dose,” the expert said.

He noted that as COVID became less intense toward the end of 2021, serious discussions began on using the same platform for routine immunization. This is where the concept of U-WIN came in 2022. It has now been piloted and is gradually being used.

U-WIN: Closing the Gap For Missed and Zero-Dose Children

The UWIN now has the mechanism to ensure that immunization is completed for everyone who registers. One user can register up to 10 people in one mobile number, including citizens/guardians, pregnant women, infants (0-1 years), children (1-7 years), and adolescents (7-19 years).

“The key issue is that tracking provides two or three important inputs. First, it ensures that everyone is getting vaccinated and that it is not dependent on memory. There is a proper record—whether a person or child has received vaccines and what their current status is, including whether the schedule is complete,” Dr Arora said.

“Second, one of the main reasons for missing or delaying the next dose was that mothers often did not remember. Fathers contributed very little to this process, but they also became involved because of the reminder system,” he added.

Another important role of U-WIN is tackling the so-called zero-dose children—those who have never been vaccinated.

“About 4–5 per cent of our eligible population falls into this category, meaning they have not received even the first pentavalent dose. On the face of it, 4–5 per cent may not seem like a huge problem. But when we look at the absolute numbers—out of 26 million—it translates into a very large number, which we cannot afford to miss. So tracking helps identify these children through the micro-plan system”.

U-WIN Enables Life-course Immunization

Also read: World Immunization Week: Vaccines Are Like Insurance, They’re Safe—Take Them, Says Dr NK Arora

“When a child is vaccinated, we know when boosters are due—at one and a half years, then at five years. But none of us remembers this. Even among well-informed parents, this is often forgotten. This system helps address that gap,” Dr. Arora said.

Further, when the same individual becomes eligible for vaccines like HPV—typically between 9 and 14 years—there is again a gap that needs to be addressed.

Certification is another benefit, as it creates a documented process, particularly for programs like oral polio vaccination.

Dr. Arora highlighted that in case of any future pandemic-like situation that requires repeated vaccinations, “we have a mechanism in place”.

“This IT platform has truly transformed the system. There is also a lot of discussion about using similar platforms for TB patients, pregnant women, and other flagship programs like non-communicable diseases. So, for India, digitalisation is at its best when we talk about U-WIN.”

Summer can invite a plethora of health problems in children. Moreover, dehydration is commonly seen when the body loses more fluids than it takes in. It is important to understand that early or subclinical dehydration can present as fatigue, irritability and reduced appetite, often going unnoticed by parents. Hence, parents need to detect the signs and symptoms of dehydration in children and seek timely help. Parents should follow the vital measures suggested by experts and safeguard their well-being.

Are children more prone to dehydration in a heatwave?

Dr Tushar Parikh, Senior Consultant Neonatologist and Head of Department at Motherhood Hospital, Kharadi, Pune, in an interaction with Health and Me, spoke about dehydration in children and how parents can identify it promptly.

“As temperatures rise during the summer months, dehydration becomes a common yet often overlooked problem in children. Dehydration occurs when the body does not have enough fluids to function properly. The causes can include inadequate fluid intake, sweating, prolonged outdoor play, and illnesses such as fever, vomiting and diarrhoea,” Dr Parikh explained.

Children are at a greater risk of dehydration as fluid loss occurs quickly through sweat. Severe dehydration is easier to identify, but early or ‘subclinical’ dehydration often goes unnoticed, silently affecting a child’s health and behaviour. Parents may assume that their child is simply tired or irritable due to the heat, but these could be early warning signs of fluid imbalance. Dehydration is often the last thing that comes to mind. However, it is frequently considered a minor issue in children. Subclinical dehydration refers to mild fluid loss that does not show obvious signs, such as extreme thirst, but still affects the body.

What are the symptoms of dehydration in children?

Dr Parikh stated that many children exhibit symptoms such as tiredness, irritability and poor appetite. They may also complain of headaches, feel dizzy, or show reduced concentration while studying. Another important sign is decreased urination or darker urine, which often goes unnoticed. Over time, if not addressed, this mild dehydration can impact energy levels and mood, and may become severe, requiring hospital admission. Hence, parents must take charge of their child’s health and seek timely attention even for mild dehydration.

How can parents help children when they are dehydrated?

Dr Parikh shared some simple tips that can help beat dehydration in childre. The expert said that dehydration can be prevented in children by encouraging them to drink water regularly. Children should ideally consume at least 2–3 litres of water daily, along with coconut water, buttermilk and fresh fruit juices to stay hydrated. Parents can also include foods such as watermelon, oranges and cucumbers, which help maintain hydration. It is advisable to limit junk, oily, canned and processed foods. Children should avoid playing outdoors during peak heat hours. Parents should dress their children in light, loose cotton clothing, which helps reduce sweating. Monitoring urine colour and frequency can be a simple way to assess a child’s hydration status. Parents should adhere to these tips to prevent dehydration in children.

The liver is one of the body’s most dependable organs, quietly doing its job in the background every single day. It handles over 500 essential functions—from filtering out toxins and producing key proteins to helping with digestion through bile and keeping your metabolism running smoothly. Most of the time, it does all of this without demanding attention.

For years, liver disease has largely been associated with alcohol. But today, a quieter and increasingly common condition is coming into focus: Non-Alcoholic Fatty Liver Disease (NAFLD), or steatosis. Closely linked to the way we live today, it is affecting a growing number of people, often without any clear warning signs. At the heart of this shift are three closely linked factors: ongoing stress, everyday eating habits that have slowly gone off track, and a noticeable drop in physical activity.

Stress, though often brushed aside, has a real and lasting impact on metabolic health. When the body is constantly in a “fight or flight” mode, cortisol levels stay high. Over time, this often shows up as fat, especially around the abdomen, while also affecting how the body handles insulin. As cells become less responsive, insulin levels rise, and the excess glucose is eventually stored as fat. This fat doesn’t just remain visible; it can quietly accumulate in the liver and begin to interfere with how it works. At the same time, persistent low-grade inflammation creates a setting where the condition can slowly worsen over time.

Diet plays an important role as well. Regularly eating processed foods, refined carbs, and added sugars can quietly tip the body into a calorie surplus, slowly straining its metabolic balance. Fructose—commonly found in sweetened drinks and packaged foods—is largely processed by the liver, putting even more pressure on it over time. When consumed in excess, it pushes the body to convert more sugar into fat, which then starts building up within liver cells over time.

A sedentary lifestyle only adds to this, often without us even realizing it. Because there is little mobility, the body becomes inefficient in using fats and carbohydrates. Over time, weight gain occurs, the body develops insulin resistance, and fatty deposits begin to form in the liver.

Sleep, which is usually ignored, is crucial. If there is insufficient or poor-quality sleep, the body’s circadian rhythm will be disrupted, as well as hormones like ghrelin and leptin, which regulate feelings of hunger and fullness. This increases food consumption and reduces energy expenditure, enabling fat deposition.

The hardest thing about NAFLD is that it is a silent disease. In the first stages of NAFLD, there will be no symptoms felt by the patient. This condition is often diagnosed incidentally when patients undergo physical checkups. Thus, untreated steatosis would eventually turn into NASH, wherein inflammation and injury of liver cells occur. The process then proceeds to fibrosis, cirrhosis, and in severe cases, transplantation of the liver.

The reassuring part is that NAFLD can often be reversed when caught early. In many cases, it comes down to simple, steady choices, eating balanced meals with whole grains, fruits, vegetables, and lean proteins, and staying physically active. Small habits like managing stress through mindfulness or yoga, and getting enough sleep, can make a real difference to metabolic health.

For those at higher risk, including people with obesity, diabetes, or high cholesterol, regular health check-ups become especially important. Spotting the condition early gives you a chance to act before it moves into more serious stages.

The liver, after all, keeps working quietly in the background every single day. Looking after it doesn’t require anything extreme, just consistent, everyday choices that add up over time.