Your body hosts trillions of bacteria, viruses, and fungi, collectively known as the microbiome. While some bacteria are linked to disease, many play essential roles in supporting your immune system, heart health, weight management, and overall well-being. This article delves into the significance of the gut microbiome and its impact on health.

What Is Gut Microbiome?

Interestingly, bacterial cells outnumber human cells in the body, with approximately 40 trillion bacterial cells compared to 30 trillion human cells. With up to 1,000 species of bacteria present in the gut, each plays a distinct role. While most bacteria contribute positively to health, some can be harmful. Together, these microbes weigh around 1–2 kilograms, functioning almost like an additional organ essential for overall well-being.

How Does Gut Microbiome Influence Your Health?

The relationship between humans and microbes has evolved over millions of years, with the gut microbiome playing a crucial role from birth. Initial exposure to microbes occurs during birth, and some evidence suggests that exposure begins in the womb. As the microbiome diversifies, it starts influencing key bodily functions:

Digestion of breast milk: Beneficial bacteria like Bifidobacteria help break down essential sugars in breast milk, supporting infant growth.

Fiber digestion: Some bacteria process fiber into short-chain fatty acids, which contribute to gut health and reduce risks of obesity, diabetes, and heart disease.

Immune system regulation: The gut microbiome interacts with immune cells, influencing how the body responds to infections.

Brain health: Emerging research suggests a link between the gut microbiome and brain function, potentially affecting mental health and neurological processes.

Gut Microbiome And Weight Management

An imbalance between beneficial and harmful microbes, known as gut dysbiosis, may contribute to weight gain. Studies on identical twins—one with obesity and the other without—suggest that microbiome composition plays a role in body weight independent of genetics. Additionally, animal studies indicate that gut bacteria can influence weight gain, even when calorie intake remains constant.

Probiotics, beneficial bacteria found in supplements and certain foods, can help restore gut balance and support weight loss, though their effects may be modest.

Gut Health And Disease Prevention

The gut microbiome plays a vital role in preventing and managing conditions like irritable bowel syndrome (IBS) and inflammatory bowel disease (IBD). Imbalances in gut bacteria may lead to bloating, cramps, and digestive issues. On the other hand, beneficial bacteria like Bifidobacteria and Lactobacilli help strengthen the intestinal lining, reducing the risk of gut-related disorders.

Impact On Heart Health

Research suggests that the gut microbiome influences heart health by affecting cholesterol levels and blood pressure. Certain harmful bacteria produce trimethylamine N-oxide (TMAO), a compound linked to blocked arteries and heart disease. However, probiotics, particularly those containing Lactobacilli, may help reduce cholesterol levels and promote cardiovascular health.

Blood Sugar Regulation And Diabetes Risk

The gut microbiome also plays a role in regulating blood sugar levels. Research on infants genetically predisposed to type 1 diabetes indicates that gut microbiome diversity declines before disease onset. Furthermore, individual variations in gut bacteria may explain why people experience different blood sugar responses to the same foods.

Connection Between Gut And Brain

The gut is physically connected to the brain through nerves, and certain bacteria help produce neurotransmitters like serotonin, which influence mood and mental health. Studies indicate that people with mental health disorders often have different gut bacteria compared to those without such conditions. Additionally, some probiotics have shown promise in alleviating symptoms of depression and anxiety.

Tips For Healthier Gut Microbiome

Maintaining a balanced gut microbiome is crucial for overall health. Here are some strategies to support gut health:

• Eat a diverse range of foods: A varied diet rich in fiber, legumes, and fruits promotes microbial diversity.
• Consume fermented foods: Yogurt, kefir, and sauerkraut contain probiotics that enhance gut health.
• Limit artificial sweeteners: Some artificial sweeteners can encourage the growth of harmful bacteria.
• Include prebiotic foods: Bananas, oats, and asparagus contain fibers that nourish beneficial bacteria.
• Breastfeed infants when possible: Breastfeeding promotes a healthier gut microbiome in babies.
• Choose whole grains: Whole grains contain fiber and beneficial compounds that support digestive health.
• Opt for a plant-based diet: Vegetarian diets may reduce inflammation and support a healthier gut microbiome.
• Consume polyphenol-rich foods: Green tea, dark chocolate, and olive oil contain compounds that foster beneficial bacteria.
• Take probiotics if needed: Probiotic supplements can help restore gut balance after disruptions, such as antibiotic use.
• Use antibiotics cautiously: While antibiotics can be life-saving, overuse can harm beneficial gut bacteria.

During the COVID-19 pandemic, the SARS-CoV-2 virus had a significant impact on the eyes, causing conjunctivitis (pink eye), with red, itchy, watery, or painful eyes.

A new study now shows that eye symptoms may also be key in understanding the severity of long COVID, a collection of symptoms that last three months or longer after your first COVID symptoms.

The new study, published in the journal Clinical Ophthalmology, showed that the new onset of eye symptoms in people with long COVID may be an indicator of more severe disease.

Also read: Long Covid Causes Lasting Brain Inflammation And Lung Injury, Reveals Study

Key Findings

Researchers from the Yale School of Medicine analyzed survey data from 595 adults who self-reported having long COVID in surveys conducted from May 2022 to October 2023. They found that nearly 60 percent of people reported new-onset of ocular symptoms.

The findings suggest that ocular symptoms in long COVID may be interpreted as vision-related manifestations that cluster with systemic post-COVID conditions. The symptoms include a new onset of :

• blurred or lost vision,
• dry eyes,
• floaters or flashes

Notably, individuals with ocular symptoms reported:

• A greater overall symptom burden,
• Financial difficulties,
• Challenges in everyday life.

Also read: Long COVID: The Story Of Those Who Are Still Dealing With Symptoms And Illnesses

What is Long COVID

Long COVID includes a wide range of symptoms or conditions that may improve, worsen, or be ongoing. While anyone who gets COVID-19 can develop Long COVID, studies have shown that some groups of people are more likely to develop Long COVID than others, including:

• Women
• People who have experienced more severe COVID-19 illness, especially those who were hospitalized or needed intensive care
• People with underlying health conditions
• People who did not get a COVID-19 vaccine

While many of the Long COVID conditions remain to be fully recognized, some people have more than one symptom that can be moderate to severe, and also impact the quality of life. According to the US CDC, they include:

• Tiredness or fatigue
• Difficulty thinking or concentrating (sometimes called “brain fog”)
• Shortness of breath or difficulty breathing
• Headache
• Dizziness on standing
• Fast-beating or pounding heart (known as heart palpitations)
• Chest pain
• Cough
• Joint or muscle pain
• Depression or anxiety
• Fever
• Loss of taste or smell

A Parliamentary Standing Committee on Health and Family Welfare has raised serious concerns about growing doctor burnout, especially among junior and senior resident doctors, and warned that it is now affecting both doctor well-being and patient safety. Noting that overworked doctors are a risk for patient safety, the panel said that fatigue-driven errors and burnout could compromise care.

To tackle this, the committee recommended that the government introduce and strictly enforce a formal “Clinical Duty Hours Regulation” policy. This should mandate fixed rest periods and monitored duty rosters, with oversight mechanisms to prevent violations, stated the panel in its 172nd report presented before the Parliament.

The recommendation comes amid growing concern over long, unregulated shifts in teaching hospitals, where residents often work extended hours with limited rest.

The panel warned that such conditions not only increase the likelihood of clinical mistakes but also contribute to burnout and mental health stress among young doctors.

What The Parliamentary Panel Said

The Panel noted that due to persistent human resource shortages, the working hours of junior and senior residents doctors often stretch from 24 to 36 hours. This increases risk of clinical errors and burnout, thereby compromising patient safety. Thus it recommended a mandatory working-hour regulatory framework:

• to minimize fatigue-induced clinical errors
• safeguard their mental and physical well-being,
• improving patient safety.

However, it noted the contractual engagement must not substitute regular appointments, as excessive reliance on contractual staff may dilute institutional accountability and continuity.

Instead, the panel has recommended adopting a "Total Support model for medical professionals" to attract and retain qualified doctors and specialists in the public health system.

Also read:India Must Integrate Technology To Build Preventive, Holistic Healthcare: Experts

What Is Clinical Duty Hours Regulation policy

The policy calls to:

• Ensure mandatory rest periods, monitored rosters.
• Ensure the presence of senior faculty in wards and in operating theatres during peak hours
• Align faculty schedules with clinical demand
• Offer Structured mentorship
• Protected teaching time for trainees to gain supervised clinical experience
• Improved working conditions, including accommodation, transportation, and administrative support, on par with the facilities afforded to senior civil servants,
• Transparent career progression with time-bound promotions.
• Integrate Yoga and the Indian Knowledge System (IKS) within the workforce to address depression and psychiatric issues.

Also read: Doctors Share Preventable Risk Factors That Can Land You in the Emergency Ward

What Is Burnout?

Burnout is distinct from depression, which influences every aspect of life and often involves persistent thoughts of hopelessness or worthlessness. Burnout typically involves limited manifestations to the work environment, although its impact can resonate into other areas.

Symptoms of Burnout

1. Exhaustion: Prolonged mental and physical depletion of your energy levels.

2. Depersonalization: Cynicism and lack of concern creep into relationships and communication.

3 Reduced Personal Achievement: Your work loses worth, and you may feel you are not up to standards, giving in to frustration and reduced originality.

These signs frequently coincide with physical signs (headaches, muscle pain, sleeplessness), emotional signs (self-doubt, loneliness, unhappiness), and behavioral signs (social withdrawal, outbursts of anger, abandonment of obligations).

Continuing the legacy of football legend Joe Thompson, his wife Chantelle revealed she is pregnant with his baby after IVF treatment using frozen embryos.

Joe Thompson died in 2025 after developing cancer for a third time - beating the illness twice.

But after the former Manchester United star was diagnosed with Hodgkin Lymphoma for a third time, which had spread to his lungs, he died aged 36.

"It just means absolutely everything. I know it's never going to replace Joe obviously. Joe's Joe. But to be able to bring his baby into the world again is beautiful," Chantelle said.

She said Joe had two visions of their family with a baby boy before he died, and he even gave her the name for the baby boy he predicted, and she got pregnant on her first attempt of IVF after he had died.

How Egg Freezing Works

Egg freezing, also known as oocyte cryopreservation, is an option that has gained significant traction in recent years. It offers women the ability to pause their biological clock and preserve the possibility of having children in the future.

Egg freezing takes a woman's unfertilized eggs from her ovaries and stores them at sub-zero temperatures to be utilized later. It is made to enable women to keep their fertility intact, especially if they are not yet ready to have a baby.

Dr. Pavithra M, Obstetrician, Gynecologist, and Infertility Specialist, told HealthandMe that the workup begins with hormone workup and evaluation of various parameters, such as age, body mass index (BMI), and ovarian reserve.

"On the second day of the menstrual cycle, baseline ultrasound scanning is performed to assess the number of follicles; thereafter, various tests of blood are conducted to assess hormone levels. If a woman's parameters are all normal, then she is administered hormonal injections for about 10-12 days."

It causes ovarian hyperstimulation and multiple mature eggs, monitored through ultrasound scans. A trigger shot is administered once the follicles have reached optimal size to help with final egg maturation. It takes 34-35 hours from the trigger shot, wherein eggs are retrieved by minimally invasive procedures under general anesthesia.

"Using a transvaginal ultrasound probe with a needle, each follicle is punctured, and the follicular fluid is aspirated. The retrieved eggs are then screened for quality before undergoing vitrification—a rapid freezing technique that minimizes ice crystal formation and cellular damage," Dr. Pavithra added. The eggs are then stored in liquid nitrogen tanks for long-term preservation.

While egg freezing is possible at various stages of life, experts recommend doing it at an optimal age -- in the late 20s or early 30s when the eggs are of higher quality-- for better outcomes.