Your body hosts trillions of bacteria, viruses, and fungi, collectively known as the microbiome. While some bacteria are linked to disease, many play essential roles in supporting your immune system, heart health, weight management, and overall well-being. This article delves into the significance of the gut microbiome and its impact on health.

What Is Gut Microbiome?

Interestingly, bacterial cells outnumber human cells in the body, with approximately 40 trillion bacterial cells compared to 30 trillion human cells. With up to 1,000 species of bacteria present in the gut, each plays a distinct role. While most bacteria contribute positively to health, some can be harmful. Together, these microbes weigh around 1–2 kilograms, functioning almost like an additional organ essential for overall well-being.

How Does Gut Microbiome Influence Your Health?

The relationship between humans and microbes has evolved over millions of years, with the gut microbiome playing a crucial role from birth. Initial exposure to microbes occurs during birth, and some evidence suggests that exposure begins in the womb. As the microbiome diversifies, it starts influencing key bodily functions:

Digestion of breast milk: Beneficial bacteria like Bifidobacteria help break down essential sugars in breast milk, supporting infant growth.

Fiber digestion: Some bacteria process fiber into short-chain fatty acids, which contribute to gut health and reduce risks of obesity, diabetes, and heart disease.

Immune system regulation: The gut microbiome interacts with immune cells, influencing how the body responds to infections.

Brain health: Emerging research suggests a link between the gut microbiome and brain function, potentially affecting mental health and neurological processes.

Gut Microbiome And Weight Management

An imbalance between beneficial and harmful microbes, known as gut dysbiosis, may contribute to weight gain. Studies on identical twins—one with obesity and the other without—suggest that microbiome composition plays a role in body weight independent of genetics. Additionally, animal studies indicate that gut bacteria can influence weight gain, even when calorie intake remains constant.

Probiotics, beneficial bacteria found in supplements and certain foods, can help restore gut balance and support weight loss, though their effects may be modest.

Gut Health And Disease Prevention

The gut microbiome plays a vital role in preventing and managing conditions like irritable bowel syndrome (IBS) and inflammatory bowel disease (IBD). Imbalances in gut bacteria may lead to bloating, cramps, and digestive issues. On the other hand, beneficial bacteria like Bifidobacteria and Lactobacilli help strengthen the intestinal lining, reducing the risk of gut-related disorders.

Impact On Heart Health

Research suggests that the gut microbiome influences heart health by affecting cholesterol levels and blood pressure. Certain harmful bacteria produce trimethylamine N-oxide (TMAO), a compound linked to blocked arteries and heart disease. However, probiotics, particularly those containing Lactobacilli, may help reduce cholesterol levels and promote cardiovascular health.

Blood Sugar Regulation And Diabetes Risk

The gut microbiome also plays a role in regulating blood sugar levels. Research on infants genetically predisposed to type 1 diabetes indicates that gut microbiome diversity declines before disease onset. Furthermore, individual variations in gut bacteria may explain why people experience different blood sugar responses to the same foods.

Connection Between Gut And Brain

The gut is physically connected to the brain through nerves, and certain bacteria help produce neurotransmitters like serotonin, which influence mood and mental health. Studies indicate that people with mental health disorders often have different gut bacteria compared to those without such conditions. Additionally, some probiotics have shown promise in alleviating symptoms of depression and anxiety.

Tips For Healthier Gut Microbiome

Maintaining a balanced gut microbiome is crucial for overall health. Here are some strategies to support gut health:

• Eat a diverse range of foods: A varied diet rich in fiber, legumes, and fruits promotes microbial diversity.
• Consume fermented foods: Yogurt, kefir, and sauerkraut contain probiotics that enhance gut health.
• Limit artificial sweeteners: Some artificial sweeteners can encourage the growth of harmful bacteria.
• Include prebiotic foods: Bananas, oats, and asparagus contain fibers that nourish beneficial bacteria.
• Breastfeed infants when possible: Breastfeeding promotes a healthier gut microbiome in babies.
• Choose whole grains: Whole grains contain fiber and beneficial compounds that support digestive health.
• Opt for a plant-based diet: Vegetarian diets may reduce inflammation and support a healthier gut microbiome.
• Consume polyphenol-rich foods: Green tea, dark chocolate, and olive oil contain compounds that foster beneficial bacteria.
• Take probiotics if needed: Probiotic supplements can help restore gut balance after disruptions, such as antibiotic use.
• Use antibiotics cautiously: While antibiotics can be life-saving, overuse can harm beneficial gut bacteria.

Delhi's air quality index (AQI) remained in the 'very poor' category on Wednesday, as the city's average AQI stood at 329 as of 7am. The Central Pollution Control Board (CPCB) data in all stations, though, showed that it was below the 'severe' range, with some locations in the 'poor' range too.

Delhi has not yet experienced the cold wave this season, however, the city is still covered with smog, and the air quality continues to threaten people's health. The Delhi winters haven't peaked yet, so what made the pollution so worse already? Gufran Beig, Chair Professor at National Institute of Advanced Studies, IISC-Campus and Founder Project Director SAFAR, writes for Indian Express that while the AQI right now may be 'very poor', "It will return, playing hide-and-seek for at least another month".

No Buffer To Protect Public Health From Delhi's Air Pollution

He says that the wind speed across Delhi and its wider airshed "dropped close to zero". This means "nothing was coming in and nothing was going out". He also noted that stubble burning in the neighboring state is not the problem, rather Delhi is choking on its own emission. He explains that the vertical dispersion was restricted by a shallow inversion layer, which was approximately 500 to 700 metres deep. Which means, emission from a fixed point sources linger where they released, and it creates a localized pollution hotspot instead of spreading, because there was almost no wind.

He explained that the atmosphere here has temporarily lost its capacity to clean itself. Even if this is for couple of days, this has become very apparent in Delhi. "When the air stands still, stagnation sets in, ventilation collapses, and the system is left with no buffer to protect public health. When the weather naps, there is nowhere left to hide. Yet, we continue to blame the weather instead of our emissions," he writes.

Read: AQI Explained: It’s Not Temperature, As Delhi CM Says, Here’s What the Air Quality Index Really Means

Could There Be A Solution?

Beig writes that if Delhi is able to cut its local pollution by 50 per cent, the pollution too could drop by 50 per cent. The emission should happen across the airshed. However, the focus should be for a long-term action on the source of emission and not short-term optics like cloud seeding, smog towers, water sprinkling or air purifiers.

In fact, as per a study published in Sustainability (MDPI), an open access journal, which mapped Delhi's air quality between 1990 to 2022 and found that transports emit around 10 to 30% of pollution, whereas agricultural residue burning, which is a seasonal source of pollution leads to less than 3% of pollution, whereas firecrackers, another seasonal source, leads to less than 1% of pollution.

Pollution's Impact On Health

However, despite the global studies highlighting the country's ever-growing pollution problem, the Centre stated that "there is no conclusive data available in the country to establish direct correlation if death/disease exclusively due to air pollution."

The study estimated: “1·5 million deaths occurred annually due to long-term exposure to PM2·5 in India every year in excess of the 5 μg/m3 that is recommended by the WHO ambient air quality guidelines.”

The study noted that every 10μg/m³ increase in annual PM2·5 concentration was associated with an 8.6 pc higher risk of all-cause mortality.

Using India’s National Ambient Air Quality Standards, researchers estimate that about 3.8 million deaths between 2009 and 2019 were linked to PM2.5 exposure. When WHO guidelines were applied, the number rose sharply to 16.6 million, nearly one-fourth of all deaths in the country. The analysis relied on advanced causal methods and high-resolution models that mapped district-level PM2.5 exposure across India, while accounting for factors such as socioeconomic status, age distribution, and indoor air pollution.

Norovirus, often called the “stomach flu” or “winter vomiting illness,” is currently circulating in California and across the United States. Health experts say proper cleaning and disinfecting can slow its spread. These precautions matter because norovirus is extremely contagious and there is no specific treatment for it, according to the Centers for Disease Control and Prevention.

Between August 1 and November 13, health officials recorded 153 norovirus outbreaks across 14 states. The CDC defines an outbreak as two or more similar illnesses linked to suspected or lab-confirmed norovirus cases. Although California is not among the states reporting outbreaks, CDC data shows a noticeable rise in positive norovirus tests throughout November across the western US.

What Is Norovirus?

Norovirus is described as a “highly contagious” virus that causes vomiting, diarrhea, and stomach cramps, according to the California Department of Public Health. It leads to acute gastroenteritis, which means inflammation of the stomach or intestines, and affects people of all ages, the CDC said.

Despite its nickname, norovirus has nothing to do with influenza. The flu is caused by the influenza virus, not norovirus, the agency clarified.

Winter Vomiting Disease: How Does The Stomach Bug Spread?

Norovirus spreads easily from person to person, especially while someone is actively sick, according to the California Department of Public Health. Symptoms usually last one to three days, but a person can still spread the virus for up to two days after they start feeling better.

The virus is present in vomit and stool and can spray into the air or settle on nearby surfaces. It can survive for weeks on uncleaned items such as countertops, phones, and doorknobs, the department said.

“You can get sick after touching or caring for someone who is sick, or after touching or eating something that is contaminated,” the department noted.

Norovirus spreads quickly in crowded or enclosed settings, including schools, child care facilities, hospitals, nursing homes, jails, and cruise ships.

According to state and federal health officials, the most common ways people catch norovirus include:

• Touching, caring for, or sharing food with someone who has norovirus
• Eating or drinking contaminated food or beverages, including undercooked shellfish like oysters
• Touching a contaminated surface and then touching your mouth before washing your hands
• Sharing a toilet or bathroom with someone who is sick
• Swallowing contaminated water, including water from swimming pools or recreational areas
• Cleaning up vomit or diarrhea without protective gear, such as gloves or a face mask

Do You Need To Disinfect After Norovirus?

“If you or someone in your household has norovirus, it’s important to clean and disinfect areas where vomiting or diarrhea occurred,” the California Department of Public Health advised. Cleaning with soap and water removes germs, while disinfecting kills those that remain.

You can use commercial disinfectants, but it’s important to read the label and make sure norovirus is listed among the germs it targets. You can also check the Environmental Protection Agency’s registration number and confirm it appears on the EPA’s List G, which includes products proven effective against norovirus.

Another option is making a bleach solution at home. The US Department of Agriculture recommends mixing 5 to 25 tablespoons of household bleach with one gallon of water. This solution should be used only on hard or nonporous surfaces and applied with a spray bottle or disposable mop, sponge, or paper towel. Let it sit for about five minutes before wiping it away.

The USDA also advises paying close attention to frequently touched items such as doorknobs, handles, and remote controls. Many disinfectant wipes do not fully kill norovirus, the agency warned.

How To Disinfect After Norovirus?

The CDC recommends wearing rubber or disposable gloves while cleaning. Use paper towels to wipe the affected area completely, then place the towels in a plastic trash bag. The California Department of Public Health also suggests wearing a face mask.

After disinfecting, clean the area again with soap and water, the CDC said. Keep in mind that vomit can aerosolize the virus, meaning surfaces several feet away may also be contaminated, according to the USDA.

Once you’re done, throw away the gloves and mask, then take out the trash, the California Department of Public Health advised.

Millions of people across the UK who take certain everyday medicines are being warned by the NHS to steer clear of a specific fruit. Health officials say combining this fruit or its juice with some medications can trigger serious reactions and unexpected side effects. The advice applies to patients prescribed some of the most commonly used drugs in the country, including certain statins, amlodipine, and medicines for anxiety. Statins, in particular, are widely prescribed to help reduce levels of “bad” LDL cholesterol in the blood.

Why Statins Are Commonly Prescribed?

Statins work by limiting how much cholesterol the liver makes. This helps slow down the build-up of fatty deposits inside the arteries, which in turn lowers the risk of heart attacks and strokes. Doctors prescribe statins both to manage high cholesterol and to prevent future heart-related problems. For most people, they are taken daily as tablets and are often part of long-term treatment.

What Does Amlodipine Do?

Amlodipine, commonly sold under the brand name Istin, belongs to a group of medicines known as calcium channel blockers. It is mainly used to treat high blood pressure. For people with hypertension, amlodipine can reduce strain on the heart and lower the risk of serious complications such as heart disease, heart attacks, and strokes.

NHS Warning On Statins Or Amlodipine

Patients taking certain forms of amlodipine, particularly calcium channel blockers, are advised not to consume grapefruit. The NHS website clearly states: “Do not take amlodipine with grapefruit juice.”

The reason lies in how grapefruit affects the body. It interferes with enzymes and transport proteins in the gut, such as CYP3A4 and P-gp, which normally help break down medicines and control how much enters the bloodstream. When these processes are blocked, higher-than-intended amounts of the drug can build up in the body, increasing the risk of side effects.

What Patients Should Keep In Mind

Not every medicine reacts the same way to grapefruit juice, which is why doctors advise checking before making changes. Always speak to your GP or pharmacist, read the information leaflet that comes with your medicine, and look out for any warnings related to grapefruit.

It is also important to understand that simply spacing the fruit and the medicine apart is not enough. In most cases, grapefruit should be avoided entirely for as long as you are on the medication, unless your doctor says otherwise. Patients are also encouraged to be cautious with other citrus fruits, such as Seville oranges, pomelos, and limes, as they can have similar effects on how medicines work.

What To Do If You’ve Already Consumed It?

If you have eaten grapefruit or had its juice while taking statins, amlodipine, or anti-anxiety medication, there is no need to panic. In many cases, a single exposure does not lead to serious harm, but it is important to stay alert. Pay attention to how your body feels over the next day or two, especially if you notice symptoms such as dizziness, muscle pain, unusual tiredness, nausea, flushing, or a sudden drop in blood pressure.

Do not stop taking your medication on your own. Skipping doses or stopping treatment abruptly can be risky, particularly for heart and blood pressure medicines. Instead, make a note of what you consumed and when, and contact your GP or pharmacist for advice. They can tell you whether any action is needed based on the specific drug, dose, and your overall health.