Your body hosts trillions of bacteria, viruses, and fungi, collectively known as the microbiome. While some bacteria are linked to disease, many play essential roles in supporting your immune system, heart health, weight management, and overall well-being. This article delves into the significance of the gut microbiome and its impact on health.

What Is Gut Microbiome?

Interestingly, bacterial cells outnumber human cells in the body, with approximately 40 trillion bacterial cells compared to 30 trillion human cells. With up to 1,000 species of bacteria present in the gut, each plays a distinct role. While most bacteria contribute positively to health, some can be harmful. Together, these microbes weigh around 1–2 kilograms, functioning almost like an additional organ essential for overall well-being.

How Does Gut Microbiome Influence Your Health?

The relationship between humans and microbes has evolved over millions of years, with the gut microbiome playing a crucial role from birth. Initial exposure to microbes occurs during birth, and some evidence suggests that exposure begins in the womb. As the microbiome diversifies, it starts influencing key bodily functions:

Digestion of breast milk: Beneficial bacteria like Bifidobacteria help break down essential sugars in breast milk, supporting infant growth.

Fiber digestion: Some bacteria process fiber into short-chain fatty acids, which contribute to gut health and reduce risks of obesity, diabetes, and heart disease.

Immune system regulation: The gut microbiome interacts with immune cells, influencing how the body responds to infections.

Brain health: Emerging research suggests a link between the gut microbiome and brain function, potentially affecting mental health and neurological processes.

Gut Microbiome And Weight Management

An imbalance between beneficial and harmful microbes, known as gut dysbiosis, may contribute to weight gain. Studies on identical twins—one with obesity and the other without—suggest that microbiome composition plays a role in body weight independent of genetics. Additionally, animal studies indicate that gut bacteria can influence weight gain, even when calorie intake remains constant.

Probiotics, beneficial bacteria found in supplements and certain foods, can help restore gut balance and support weight loss, though their effects may be modest.

Gut Health And Disease Prevention

The gut microbiome plays a vital role in preventing and managing conditions like irritable bowel syndrome (IBS) and inflammatory bowel disease (IBD). Imbalances in gut bacteria may lead to bloating, cramps, and digestive issues. On the other hand, beneficial bacteria like Bifidobacteria and Lactobacilli help strengthen the intestinal lining, reducing the risk of gut-related disorders.

Impact On Heart Health

Research suggests that the gut microbiome influences heart health by affecting cholesterol levels and blood pressure. Certain harmful bacteria produce trimethylamine N-oxide (TMAO), a compound linked to blocked arteries and heart disease. However, probiotics, particularly those containing Lactobacilli, may help reduce cholesterol levels and promote cardiovascular health.

Blood Sugar Regulation And Diabetes Risk

The gut microbiome also plays a role in regulating blood sugar levels. Research on infants genetically predisposed to type 1 diabetes indicates that gut microbiome diversity declines before disease onset. Furthermore, individual variations in gut bacteria may explain why people experience different blood sugar responses to the same foods.

Connection Between Gut And Brain

The gut is physically connected to the brain through nerves, and certain bacteria help produce neurotransmitters like serotonin, which influence mood and mental health. Studies indicate that people with mental health disorders often have different gut bacteria compared to those without such conditions. Additionally, some probiotics have shown promise in alleviating symptoms of depression and anxiety.

Tips For Healthier Gut Microbiome

Maintaining a balanced gut microbiome is crucial for overall health. Here are some strategies to support gut health:

• Eat a diverse range of foods: A varied diet rich in fiber, legumes, and fruits promotes microbial diversity.
• Consume fermented foods: Yogurt, kefir, and sauerkraut contain probiotics that enhance gut health.
• Limit artificial sweeteners: Some artificial sweeteners can encourage the growth of harmful bacteria.
• Include prebiotic foods: Bananas, oats, and asparagus contain fibers that nourish beneficial bacteria.
• Breastfeed infants when possible: Breastfeeding promotes a healthier gut microbiome in babies.
• Choose whole grains: Whole grains contain fiber and beneficial compounds that support digestive health.
• Opt for a plant-based diet: Vegetarian diets may reduce inflammation and support a healthier gut microbiome.
• Consume polyphenol-rich foods: Green tea, dark chocolate, and olive oil contain compounds that foster beneficial bacteria.
• Take probiotics if needed: Probiotic supplements can help restore gut balance after disruptions, such as antibiotic use.
• Use antibiotics cautiously: While antibiotics can be life-saving, overuse can harm beneficial gut bacteria.

In 2022, the National AIDS Control Organisation (NACO) of India published the National Technical Guidelines for PrEP pr the pre-exposure prophylaxis (PrEP), a medicine that reduces the risk of HIV infection. It has been four years since then and the access still remains limited. It was called a novel strategy to deal with HIV, however, there not has been public rollout and government too has not distributed it. This means awareness remain low and the cost is too high for everyone to afford it. PrEP is available for Rs 2,200 to Rs. 3,000 a month in private markets and at subsidized rates in just a few handful of non-profits that too in select cities.

HIV was first identified in 1986 in India, since then the country has made gradual progress in controlling the disease. As per the Sankalak, Status of National AIDS and STD Response Report 2024, released by NACO, HIV prevalence among adults, which is considered between 15 to 49 years was 0.20 per cent. This represented a 44 per cent decline since 2010.

However, the prevalence and incidence remain high in vulnerable populations. While the incidence in general population was 0.05 per 1,000 uninfected persons in 2023, men who have sex with men (MSM) see an incidence of 1.55, Hijra/Transgender persons (HTG) have 2.76, and female sex workers (FSW) are at 3.33. This means that nearly a million of FSWs, 350,000 MSM and 96,000 HTGs have the disease. A report from India Spend notes that it is not an actual headcount, but an estimation, which represents that the real number could be more than that.

How Does PrEP Work?

HIV spreads in the human body by targeting and infecting T cells or the critical white blood cells of our immune system. PrEP blocks HIV from replicating inside T cells after exposure. It stops the infection from taking hold. PrEP has also come in form of oral pill which could reduce the chances of contracting HIV through sexual contact or injection drug use.

Studies have documented a sharp fall in HIV infections in communities where Pre-Exposure Prophylaxis (PrEP) is widely used. In Australia, a study involving more than 62,000 people found that government-subsidized oral PrEP helped reduce new HIV cases by 78% among men who took the medication for at least 60% of days between 2018 and 2023. PrEP works best when taken daily, lowering the risk of HIV transmission through sex by over 99% and by more than 74% through infected needles. It can be stopped when a person is no longer engaged in high-risk activities such as having multiple sexual partners or injecting drugs.

Last year, the United States Food and Drug Administration (FDA) approved twice-yearly injectable PrEP, lenacapavir. The World Health Organization recommended for a fast rollout. Maker Gilead Sciences signed agreements with generic manufacturers, including Dr Reddy’s Laboratories, to make the jab available in 120 low- and middle-income countries at lower cost.

Amid this, Zimbabwe become the first African country to roll out the breakthrough injection, while Japan approved the pill version made by Gilead Sciences - Truvada.

From childhood, many girls are taught to be agreeable, responsible and perfect in everything they do. They are praised for being obedient, hardworking and emotionally controlled. Over time, this expectation can shape behavior in ways that may quietly harm mental and physical health.

This pattern is often referred to as “Good Girl Syndrome”. While it is not a formal medical diagnosis, doctors say the effects of constantly trying to live up to expectations can be very real. The pressure to appear composed and capable all the time can lead to emotional suppression, chronic stress and eventually hormonal disturbances.

To understand how this pressure affects the body, NDTV Health spoke with Dr. Y. D. Meherprasad, Senior Consultant in Endocrinology and Preventive Healthcare at MGM Malar Hospital, Chennai, who says he has observed this pattern among many young women in his clinical practice.

The Hidden Stress Behind Perfection

Good Girl Syndrome describes a behavioral pattern where individuals, often women, feel compelled to meet expectations without showing weakness or stress. This can translate into people pleasing behaviour, fear of conflict and difficulty setting boundaries.

Dr. Meherprasad explains that constantly trying to maintain this image can create a persistent stress response in the body.

“Hormonal imbalances are being noticed in young Indian women associated with the Good Girl Syndrome, where women are always trying to meet expectations and are continuously successful, all without showing any signs of stress,” he told NDTV Health.

According to him, the problem arises when emotions are suppressed for long periods. “When women suppress emotions for long periods, the body remains in a state of constant stress response,” he said.

Emerging research in the field of psychoneuroendocrinology suggests that emotional stress can directly influence hormonal regulation in the body.

The Cortisol Connection

At the centre of this process is cortisol, the body’s main stress hormone. Normally, cortisol rises briefly during stressful situations and then returns to normal levels once the threat passes.

However, when stress becomes constant, cortisol levels can remain elevated for long periods.

Studies have shown that chronic high cortisol can disrupt reproductive hormones. One effect described in research is sometimes called “progesterone steal,” where the body prioritizes producing stress hormones instead of reproductive hormones.

Low progesterone levels can contribute to irregular menstrual cycles, acne and other hormonal symptoms that many young women experience.

Stress, Insulin Resistance And PCOS

Dr. Meherprasad says chronic stress may also contribute to metabolic changes. In some cases, it can mimic or worsen conditions such as Polycystic Ovary Syndrome (PCOS).

When cortisol levels remain high, the body releases more glucose into the bloodstream to provide energy for a perceived threat. If that energy is not used through physical activity, insulin levels rise to regulate blood sugar.

Over time, this can lead to insulin resistance, which is a key factor associated with PCOS. Women may experience abdominal weight gain, irregular ovulation and difficulty managing their weight.

Warning Signs The Body May Be Struggling

The effects of prolonged stress do not appear overnight. They often show up gradually through subtle changes in the body.

Dr. Meherprasad says menstrual irregularities are one of the early warning signs. Some women may experience delayed cycles or even a temporary halt in ovulation.

Sleep disturbances are also common. Many women report difficulty falling asleep because their minds remain constantly active, leading to fatigue the next day.

Other symptoms may include mood swings, persistent anxiety, brain fog and difficulty losing weight despite maintaining a careful diet.

Restoring Balance

Dr. Meherprasad says addressing these hormonal issues requires both medical evaluation and lifestyle changes.

Regular hormone screenings can help detect issues related to thyroid function, insulin levels and reproductive hormones such as LH and FSH. Early treatment is important if conditions such as PCOS or thyroid dysfunction are present.

Equally important is addressing the emotional component of chronic stress.

“Hormonal imbalance is not only physical but also closely linked to emotional health,” said the doctor.

He recommends prioritizing adequate sleep, regular physical activity and practices such as yoga that help calm the body’s stress response. Creating space for emotional expression through journaling or therapy can also help reduce long term stress.

In a culture that often rewards perfection, doctors say it may be time to rethink the idea of the “perfect girl”. Sometimes, protecting one’s health begins with allowing space for imperfection.

Cancer deaths in the United Kingdom have dropped to their lowest recorded levels, according to new data from the charity Cancer Research UK. The figures show that cancer death rates have fallen by 11 per cent in the past decade, reflecting progress in early detection, screening, treatment and prevention.

Researchers estimate that around 247 people in every 100,000 in the UK now die from cancer each year. This is a significant decline from the peak recorded in 1989, when about 355 people per 100,000 died annually from the disease. Overall, that represents a 29 per cent reduction over the past few decades.

Experts say this steady improvement is the result of sustained scientific progress, improved healthcare systems and public health measures that target risk factors such as smoking.

Major Declines In Several Common Cancers

The new data highlights falling death rates across several major cancers. Ovarian cancer deaths have dropped by 19 per cent over the past ten years, up to 2024. Lung cancer deaths have fallen by 22 per cent during the same period, reflecting the long-term impact of reduced smoking rates and better treatment options.

Deaths from stomach cancer have seen one of the most dramatic improvements, dropping by 34 per cent in the past decade. Bowel cancer deaths have decreased by six per cent, while breast cancer deaths have fallen by 14 per cent.

Other cancers have also seen notable declines. Cervical and prostate cancer deaths have both dropped by 11 per cent. Deaths from leukemia are down by nine per cent, while esophageal cancer deaths have fallen by 12 per cent.

Experts say improved diagnosis, new therapies and better awareness are playing a key role in these trends.

Screening And Vaccination Making A Difference

One of the biggest public health successes has been the decline in cervical cancer deaths. Since the 1970s, deaths from cervical cancer have fallen by around 75 per cent in the UK. Health experts attribute much of this progress to the national cervical screening programme run by the NHS.

Screening helps detect abnormal cells early, allowing treatment before cancer develops or spreads.

Another major contributor is the human papillomavirus vaccine, commonly known as the HPV vaccine. The vaccine protects against the virus responsible for most cervical cancer cases. It is routinely offered to schoolchildren in the UK, and since its introduction in 2008, at least 6.5 million young people have received it.

Public health experts believe the vaccine will continue to reduce cervical cancer rates in the coming decades.

Some Cancer Death Rates Still Rising

Despite the overall progress, the data also shows worrying increases in deaths from certain cancers. Gallbladder cancer deaths have risen by 29 per cent, while deaths from eye cancer have increased by 26 per cent.

Liver cancer deaths are up by 14 per cent, and kidney cancer deaths have risen by five per cent. Meanwhile, death rates for thyroid cancer, pancreatic cancer and melanoma have remained largely unchanged.

Another important trend is that the total number of people dying from cancer continues to rise. This is largely due to population growth and an ageing population, as cancer risk increases with age.

Calls For More Research And Clinical Trials

Experts say the long-term decline in cancer deaths reflects decades of medical research and innovation. However, they stress that continued investment is necessary to sustain progress.

Cancer Research UK researcher Dr Sam Godfrey said the figures show the impact of scientific breakthroughs over many years. He has called on the government to support more clinical trials and ensure that NHS staff have enough time and resources to take part in life saving research.

Public health policies such as smoking bans, along with screening programmes and vaccines, are also credited with helping drive down cancer deaths across the country.