Your body hosts trillions of bacteria, viruses, and fungi, collectively known as the microbiome. While some bacteria are linked to disease, many play essential roles in supporting your immune system, heart health, weight management, and overall well-being. This article delves into the significance of the gut microbiome and its impact on health.

What Is Gut Microbiome?

Interestingly, bacterial cells outnumber human cells in the body, with approximately 40 trillion bacterial cells compared to 30 trillion human cells. With up to 1,000 species of bacteria present in the gut, each plays a distinct role. While most bacteria contribute positively to health, some can be harmful. Together, these microbes weigh around 1–2 kilograms, functioning almost like an additional organ essential for overall well-being.

How Does Gut Microbiome Influence Your Health?

The relationship between humans and microbes has evolved over millions of years, with the gut microbiome playing a crucial role from birth. Initial exposure to microbes occurs during birth, and some evidence suggests that exposure begins in the womb. As the microbiome diversifies, it starts influencing key bodily functions:

Digestion of breast milk: Beneficial bacteria like Bifidobacteria help break down essential sugars in breast milk, supporting infant growth.

Fiber digestion: Some bacteria process fiber into short-chain fatty acids, which contribute to gut health and reduce risks of obesity, diabetes, and heart disease.

Immune system regulation: The gut microbiome interacts with immune cells, influencing how the body responds to infections.

Brain health: Emerging research suggests a link between the gut microbiome and brain function, potentially affecting mental health and neurological processes.

Gut Microbiome And Weight Management

An imbalance between beneficial and harmful microbes, known as gut dysbiosis, may contribute to weight gain. Studies on identical twins—one with obesity and the other without—suggest that microbiome composition plays a role in body weight independent of genetics. Additionally, animal studies indicate that gut bacteria can influence weight gain, even when calorie intake remains constant.

Probiotics, beneficial bacteria found in supplements and certain foods, can help restore gut balance and support weight loss, though their effects may be modest.

Gut Health And Disease Prevention

The gut microbiome plays a vital role in preventing and managing conditions like irritable bowel syndrome (IBS) and inflammatory bowel disease (IBD). Imbalances in gut bacteria may lead to bloating, cramps, and digestive issues. On the other hand, beneficial bacteria like Bifidobacteria and Lactobacilli help strengthen the intestinal lining, reducing the risk of gut-related disorders.

Impact On Heart Health

Research suggests that the gut microbiome influences heart health by affecting cholesterol levels and blood pressure. Certain harmful bacteria produce trimethylamine N-oxide (TMAO), a compound linked to blocked arteries and heart disease. However, probiotics, particularly those containing Lactobacilli, may help reduce cholesterol levels and promote cardiovascular health.

Blood Sugar Regulation And Diabetes Risk

The gut microbiome also plays a role in regulating blood sugar levels. Research on infants genetically predisposed to type 1 diabetes indicates that gut microbiome diversity declines before disease onset. Furthermore, individual variations in gut bacteria may explain why people experience different blood sugar responses to the same foods.

Connection Between Gut And Brain

The gut is physically connected to the brain through nerves, and certain bacteria help produce neurotransmitters like serotonin, which influence mood and mental health. Studies indicate that people with mental health disorders often have different gut bacteria compared to those without such conditions. Additionally, some probiotics have shown promise in alleviating symptoms of depression and anxiety.

Tips For Healthier Gut Microbiome

Maintaining a balanced gut microbiome is crucial for overall health. Here are some strategies to support gut health:

• Eat a diverse range of foods: A varied diet rich in fiber, legumes, and fruits promotes microbial diversity.
• Consume fermented foods: Yogurt, kefir, and sauerkraut contain probiotics that enhance gut health.
• Limit artificial sweeteners: Some artificial sweeteners can encourage the growth of harmful bacteria.
• Include prebiotic foods: Bananas, oats, and asparagus contain fibers that nourish beneficial bacteria.
• Breastfeed infants when possible: Breastfeeding promotes a healthier gut microbiome in babies.
• Choose whole grains: Whole grains contain fiber and beneficial compounds that support digestive health.
• Opt for a plant-based diet: Vegetarian diets may reduce inflammation and support a healthier gut microbiome.
• Consume polyphenol-rich foods: Green tea, dark chocolate, and olive oil contain compounds that foster beneficial bacteria.
• Take probiotics if needed: Probiotic supplements can help restore gut balance after disruptions, such as antibiotic use.
• Use antibiotics cautiously: While antibiotics can be life-saving, overuse can harm beneficial gut bacteria.

Delhi AQI turns 'very poor' on Friday, with overall Air Quality Index hitting at 331 at 7am. As per the Central Pollution Control Board (CPCB) data, Jahangirpuri was the worst-affected area, and had its AQI at 405, under the 'severe' zone. Reports have shown that PM2.5 or the particulate matter levels in Delhi is well over 30 times the World Health Organization (WHO) safe standard.

However, the Minister of State for Environment Kirti Vardhan Singh said in Parliament that the WHO guidelines are only meant to help nations frame their own standards, factoring in geography, environmental conditions and local circumstances. He said that no global authority conducts official rankings, the government evaluates air quality within the country through its annual Swachh Vayu Survekshan, which ranks 130 cities under the National Clean Air Programme (NCAP) based on improvement efforts.

This was the Centre's response on Thursday to a question in Rajya Sabha on India's stand on IQAIr's World Air Quality Ranking, the WHO Global Air Quality Database, the Environmental Performance Index (EPI), and the Global Burden of Disease (GBD) metrics.

While this was happening in the Parliament, the Central government's 'Air Quality Early Warning System for Delhi' said that "The air quality is likely to be in the Very Poor category from 11.12.2025 to 13.12.2025. The outlook for the subsequent 6 Days: The air quality is likely to be in the Very Poor category.

So, what is to be considered? Is the central government evading India's global air quality rankings? Previously, the union government also denied any deaths directly linked to air pollution.

However, the GBD data found that at least 15% of all deaths in 2023 were related to air pollution. The analysis was based on the data released by the Institute for Health Metrics and Evaluation (IHME). The data estimated around 17,188 deaths in the national capital, all of which were linked to long-term exposure to particulate matter or PM2.5. This means 1 in every 7 deaths in Delhi could be traced to city's toxic air.

Also Read: Connection Between Migration And Pollution: People Are Leaving City To Be Away From Delhi's Toxic Air

Is The Government Doing Anything?

Amid the continuously worsening air condition in Delhi, the government has now formed an 'expert group' to combat air pollution as health crisis rise.

The panel will study how pollution builds up from human activity as well as natural causes and will recommend technology upgrades, policy reforms, and sector specific interventions that can be put into action.

The group will be chaired by retired IAS officer and former Union Environment Secretary Leena Nandan. Other members include former CPCB member secretary Dr JS Kamyotra, IIT Delhi professor emeritus Mukesh Khare, IIT Kanpur professor emeritus Mukesh Sharma, and Dr Suneel Pandey, director of Circular Economy and Waste Management at TERI. Representatives from CAQM, the IMD, APAG, PHDCCI and senior officials from the Delhi government are also part of the group. The Secretary of Environment and Forest is a member, and the DPCC chairman will serve as member secretary.

This expert panel will act as a high level advisory body, offering clear, actionable guidance that can shape both emergency responses and long term reforms. It will track the progress of current pollution control programs, study global best practices, and flag where corrections are needed. The group will meet every month, either in person or virtually, and will receive administrative support from the Delhi Pollution Control Committee. The initial tenure is six months, with the option to extend if required.

What Does Government Data Tell Us About Pollution And Health?

The government revealed that in the span of three years between 2022 to 2024, Delhi's six state run hospitals recorded 200,000 cases of acute respiratory illness. The government also said in parliament that more than 30,000 people were hospitalized in Delhi over three years with respiratory illness.

For weeks Delhi's PM2.5 levels have stayed 20 times the limit recommended by the World Health Organization (WHO). In the span of three years, here is how many case Delhi's six major hospitals have recorded:

• 2022: 67,054
• 2023: 69,293
• 2024: 68,411

"Analysis suggests that increase in pollution levels was associated with increase in number of patients attending emergency rooms. However, this study design cannot provide confirmation that the association is causal," the government told parliament.

A new Ontario study revealed that there has been a 157 percent increase in the prescriptions for stimulant medications used to treat attention-deficit hyperactivity disorder (ADHD). The study noted that the prescriptions skyrocketed between 2015 to 2023. This means the prescriptions have increased four times each year from 2020 to 2023, as compared to 2015 to 2019, linked pandemic and mental health conditions to be a reason for the same. The study is published in JAMA Network Open. Researchers at ICES, the non-profit group formally known as the Institute for Clinical Evaluative Sciences in Toronto, along with North York General Hospital and the Hospital for Sick Children.

Growth Accelerates After the Pandemic

According to the study, prescription rates began climbing steadily before the pandemic but accelerated sharply from 2020 onward. Between 2020 and 2023, stimulant prescriptions rose nearly four times faster each year compared with the period between 2015 and 2019. This shift suggests that life disruptions during lockdowns may have pushed many people to seek help for long-standing attention and focus struggles.

Using data from Ontario’s Narcotics Monitoring System, the researchers tracked prescriptions for stimulant medications, the primary treatment for ADHD. These drugs increase dopamine and other chemicals in the brain, helping people concentrate, regulate emotions and think more clearly.

The overall result was a 157 percent rise in new stimulant prescriptions over eight years.

Women See the Largest Increase

The most striking finding is how dramatically rates have increased among women. Women between 25 and 44 saw a surge of more than 420 percent. For men in the same age group, the increase was nearly 220 percent. Younger women also experienced a major rise, with prescriptions up almost 370 percent among those aged 18 to 24.

By 2023, women over the age of 18 were receiving stimulant prescriptions at higher rates than men, reversing long-standing patterns in ADHD diagnosis and treatment. Historically, boys and men have been diagnosed more often because the condition has been viewed through a male-focused lens.

Experts say this makeover in the data reflects a deeper shift in understanding ADHD in females. Girls often present with symptoms of quiet inattention rather than the hyperactivity commonly seen in boys. Because they tend not to disrupt classrooms, they are frequently overlooked and reach adulthood without a diagnosis.

Pandemic, Social Media and Online Clinics Play a Role

Heidi Bernhardt, founder of the Centre for ADHD Awareness Canada, says the pandemic played a major role in changing how people experienced and recognized ADHD symptoms. With routines disrupted and support systems diminished, many adults began to notice difficulties that had been manageable before.

At the same time, TikTok, Instagram and other social platforms created a surge in conversations about neurodiversity. Online mental health services also became more accessible, making it easier for adults to pursue an assessment, sometimes for the first time in their lives.

Awareness Helps, But Misdiagnosis Is a Concern

Specialists welcome the fact that more women are now being correctly diagnosed. Dr. Anita Parhar of the ADHD Centre for Women says the rising prescription rates show that women are finally being acknowledged and treated for symptoms they may have lived with for years.

But researchers also caution that the rapid increase raises the possibility of misdiagnosis. Some symptoms linked to ADHD can overlap with anxiety disorders or other mental health issues. When ADHD is diagnosed incorrectly, the underlying condition may go untreated.

Pediatrician and ADHD specialist Jane Liddle notes that failure to treat true ADHD carries its own risks. Untreated ADHD is associated with higher rates of anxiety, depression, academic problems and addiction.

As prescriptions continue to rise, experts say the priority should be ensuring accurate diagnosis and access to appropriate care, especially as awareness of ADHD continues to evolve.

As 2025 comes to an end, one thing is clear, this year has been a year of remarkable shifts in how we understand health. This year, there have been breakthroughs, redesigns, and achievements in the healthcare sector, which has changed many lives. Scientists and doctors have pushed their boundaries in ways to save lives, make patients more comfortable and Health and Me lists down 5 such breakthroughs that defined the year 2025.

Reinventing Speculum: The Flower That May Transform Pelvic Exams

Few medical tools have stayed as frozen in time as the vaginal speculum. Cold, metallic, and intimidating, its origin traces back to Dr. James Marion Sims in the mid-19th century, during experiments carried out unethically on enslaved women. Beyond its history, patients have long reported pain, anxiety, and emotional distress linked to it. But this year, a young design team dared to ask what would happen if pelvic exams could feel safe.

Enter Lilium, a flower-inspired speculum created by Delft University engineers Tamara Hoveling and Ariadna Izcara Gual. Made with soft plastic and shaped to bloom like a lily, it opens gently, eliminates the harsh clicking sound, and uses a tampon-like applicator for insertion. Designed to feel familiar and symbolically comforting, Lilium represents a shift toward trauma-informed, patient-first gynecological care—something long overdue.

Zaynich: India Launches Its First New Antibiotic in 30+ Years

For 28-year-old Sahil Mehra from Mumbai, a severe, drug-resistant Pseudomonas infection left his kidneys failing and his doctors nearly out of options. Even last-resort antibiotics couldn’t stop the superbug.

Then came Zaynich, India’s first new antibiotic in more than three decades. Developed by Wockhardt, it combines cefepime, a fourth-generation cephalosporin, with zidebactam, a novel β-lactam enhancer that boosts the drug’s power against tough bacteria. Early reports and trials suggest a 97% effectiveness against drug-resistant Gram-negative bacteria and even a 20% higher cure rate than meropenem in Phase 3 studies. Within four days of receiving Zaynich, Mehra’s condition stabilized—a reminder of why antibiotic innovation is essential in the age of superbugs.

A Powerful Cholesterol-Lowering Pill Could Change Heart Care

High LDL cholesterol remains one of the biggest drivers of cardiovascular disease. While statins help, many people never reach target levels. Injectable PCSK9 inhibitors work well but remain expensive and less accessible.

This year, an experimental daily pill—enlicitide—showed promise of changing that equation. In the Phase 3 CORALreef Lipids trial involving 2,912 adults, enlicitide reduced LDL-C levels by 55.8% at 24 weeks, with post-hoc analysis suggesting reductions up to 59.7%. With a safety profile similar to placebo, enlicitide could become the first oral PCSK9 inhibitor to make potent cholesterol control easier and more widely available.

Zombie Cell: A Longevity Pill From China Claims Life Up to 150 Years

A Shenzhen-based biotech company sparked global debate by claiming it has developed a pill that targets ageing at the cellular level. The pill focuses on clearing “zombie cells”—old cells that refuse to die and trigger inflammation. Made with compounds derived from grape seeds, early animal lab work suggests potential lifespan extension. While far from proven in humans, the idea that such a pill could stretch life to 120–150 years captured the world’s imagination and intensified conversations around longevity science.

The World’s First Single-Dose Dengue Vaccine Gets Approved

With dengue cases hitting record levels globally, Brazil approved the world’s first single-dose dengue vaccine, called Butantan-DV. Developed by the Butantan Institute in collaboration with Wu Xi, it uses a live attenuated virus and is currently approved for ages 12 to 59. Until now, the only dengue vaccine required two doses months apart. This single-shot version could transform dengue prevention, especially in tropical countries facing surges linked to rising temperatures.