The heat waves are rising all over the world and causing a lot of damage. While there are issues of dehydration and heat strokes, studies are suggesting that it might also be responsible for declining mental health, the heat among other things is not only affecting the physicality of human beings but is also having adverse mental health.

Emotional distress: The heat can trigger mood swings, making you feel irritable, anxious, depressed, or even aggressive. You may not be able to predict your reaction, you may be good one moment and then any minor inconvenience will make you angry or sad. Heat often triggers that helplessness in people.

Scattered Focus: Concentrating on tasks becomes a struggle when it's hot. Simple things feel overwhelming, and staying focused is a challenge. While you may be in the zone working on completing something, the heat and sweating will disrupt your flow and then you will not be able to focus on anything other than the heat.

Sleepless Nights: High temperatures, especially at night, disrupt your sleep. This lack of rest can leave you feeling tired, and grumpy, and worsen existing mental health issues. All humans require a comfortable temperature to sleep in, if your body is too wound up or heated up, it will not be able to relax and sleep.

Feeling the Pressure: The heat can pile on stress and make you feel overwhelmed. Concerns about the heat itself or its impact on other aspects of your life can contribute to this feeling. You will feel overwhelmed and unable to work on anything else. The heat makes you feel a certain helplessness, as you cannot stop the sun or turn down the heat.

Body Blues: The heat can cause physical symptoms that affect your mental well-being. Headaches, fatigue, dizziness, and nausea can all contribute to anxiety and low mood. When your body is already fatigued, the urge to do anything else disappears. Your body is drained of energy to function at all and will seek rest and sleep.

Behavioural Shifts: The heat can influence your behaviour. You might act impulsively or have difficulty managing anger. It's like the heat turns up your emotional thermostat. When your body and brain are overheating, it is difficult to think straight and you will grasp at straws to release this energy and pressure off of you.

Some other side effects of the heat are.

• Mental Health Flare-Ups: If you already have a mental health condition, hot weather can worsen your symptoms. Existing depression, anxiety, bipolar disorder, or schizophrenia might feel more intense.
• Heat and Suicide Risk: Studies show a disturbing link between hot weather and increased suicide rates, particularly among men and older adults. Hot weather can be a tipping point for those already struggling.
• Heatwave Hospitalizations: When temperatures soar, people with existing mental health issues may require increased hospitalization. This highlights the need for healthcare systems to be prepared for heat waves.
• Climate Change and Mental Health: Climate change is leading to more frequent heatwaves. Research suggests this could lead to a rise in mental health problems and suicides. Taking action against climate change is crucial for protecting mental well-being.

Heart disease is still the number one killer worldwide, and "bad" cholesterol – or LDL (low-density lipoprotein) – is at the heart of this health epidemic. Even after decades of depending on statins to manage high cholesterol, millions still have perilously high levels of LDL. But a revolutionary combination of drugs could finally bring hope to those who are fighting to keep their heart health in check, even with standard treatment.

A new cholesterol-lowering drug is a game-changer. A new two-drug combination—obicetrapib plus ezetimibe—has proven dramatic impacts on lowering LDL cholesterol in people who have high LDL levels even after they are on statins. In a new Phase 3 clinical trial from the Cleveland Clinic, this two-drug combination delivered a staggering 49% decrease in LDL cholesterol after only 12 weeks.

The results were presented at the European Atherosclerosis Society congress in Glasgow and simultaneously published in The Lancet, lending authority to what is potentially a large change in the treatment of cardiovascular disease. The trial enrolled 407 patients with a mean age of 68, all with LDL above the American Heart Association's suggested cutoff of 70 mg/dL for patients at high risk. Even while continuing their usual cholesterol-lowering medications, only those who received the new combo pill experienced such dramatic reductions in LDL.

Dr. Ashish Sarraju, the lead author and preventive cardiologist, stressed the need for increasing choices for patients. "In patients at higher risk, you want to lower LDL as soon as possible and maintain it as long as possible," he said. For those who have already had a heart attack or stroke—or are at high risk—this therapy may provide the aggressive lowering of cholesterol that statins alone cannot provide.

Why Statins Alone Are Not Enough Any More?

Statins have been the front-line therapy for high cholesterol for many years but have their weaknesses. They are intolerable to some patients, and in others, they fail to produce the LDL falls required to avoid repeat cardiovascular events. Even high-intensity statin therapy proves inadequate in those at highest risk.

Dr. Corey Bradley of Columbia University observes, "Many people have such a high LDL they will require multiple agents to control it." That's where the obicetrapib-ezetimibe combination steps in—providing a synergistic solution for patients who have reached a wall with conventional meds.

What Makes This Drug Different?

It’s worth noting that not all drugs in the same category have shown benefits in the past. CETP inhibitors, a class of drugs that includes obicetrapib, have previously failed to demonstrate protection against heart attacks or strokes in clinical trials. However, experts remain cautiously optimistic about this new formulation.

Dr. Robert Rosenson of Mount Sinai Health System said, "Some of the drugs in this class have not prevented strokes or heart attacks. But I am hopeful cautiously." NewAmsterdam Pharma, the Dutch firm behind obicetrapib, is now carrying out additional trials to see if this drug not only reduces LDL but also major cardiovascular events.

NewAmsterdam Pharma has revealed it will sit down with the U.S. Food and Drug Administration this year to talk about regulatory avenues for approval. Assuming everything goes according to plan, the new combination may soon be accessible to millions of patients in the U.S. and internationally.

Ways to Lower Your Cholesterol Naturally

Though new drugs such as this provide a hopeful answer for at-risk patients, they don't eliminate the necessity for ongoing lifestyle changes. The CDC says that only 20% of people can control their LDL levels with lifestyle changes alone. Nevertheless, every little bit helps—particularly when used in conjunction with medication.

Low cholesterol doesn't always mean taking medication—there are potent, natural lifestyle modifications that can do wonders to your lipid profile and heart health. Below are ways you can lower bad cholesterol (LDL) and increase good cholesterol (HDL) with realistic, long-term changes:

Follow a Heart-Healthy Diet

Emphasize a diet high in soluble fiber, healthy fat, and plant foods. Eat oats, legumes, apples and berries, vegetables, and whole grains. Replace saturated fat in red meat and whole milk dairy with heart-healthy fats like those of avocados, nuts, seeds, and olive oil. Eliminate trans fats altogether—they increase LDL and decrease HDL.

Get Moving with Regular Exercise

Physical activity tends to increase good cholesterol and decrease bad cholesterol. Be as active as possible throughout the week; aim for 150 minutes of brisk walking, cycling, or swimming per week. Even small activities like taking the stairs or taking the short walk after a meal can pay off in the long run.

Maintain a Healthy Weight

Losing a few pounds will improve cholesterol levels. Being overweight helps to raise LDL levels and lower HDL. Practice mindful eating, portioning, and consistent activity to induce a calorie deficit that allows for gradual, healthy weight loss.

Quit Smoking

Smoking injures the blood vessels, decreases good cholesterol, and places one at an increased risk for heart disease. After quitting in weeks, one starts to recover in terms of HDL cholesterol, and a year later, the risk for heart disease lessens significantly.

Limit Alcohol Intake

Even if moderate drinking contributes a little positive effect on the level of HDL, more drinking raises both total cholesterol and triglycerides. If you drink, consume it in moderate amounts—limited to one alcoholic beverage per day for women and two for men.

Manage Stress Effectively

Chronic stress can indirectly influence cholesterol by encouraging unhealthy habits such as overeating or smoking. Practice stress-reducing activities such as yoga, deep breathing, meditation, or simply taking a walk in nature to promote heart health.

Select Plant Sterols and Supplements Carefully

Some plant compounds such as sterols and stanols can inhibit the absorption of cholesterol. You can get these in fortified foods and natural supplements. Always consult a healthcare professional before taking any new supplement.

The release of this new combination therapy represents a possible paradigm shift in cholesterol treatment—especially among aging populations, genetically predisposed individuals, and those with underlying cardiovascular disease. If FDA-approved and integrated into clinical practice, this combination drug may have a profound impact on reducing the global incidence of heart disease.

These whole-body, evidence-based strategies provide a map to naturally enhance cholesterol and heart health—without resorting solely to prescription drugs.

Cancer is often seen as a disease that primarily affects older individuals. After all, the average age of diagnosis is 66, and the risk of developing cancer rises steadily with age. However, a disturbing trend is emerging: more young adults are being diagnosed with cancer before the age of 50. This article explores this shift, its potential causes, and the types of cancers that are rising in younger populations.

In the United States, cancer is diagnosed in fewer than 25 out of every 100,000 people under the age of 20, and it accounts for just 1 percent of all cancer diagnoses, according to the National Cancer Institute (NCI). By the time individuals reach the ages of 45 to 49, the incidence of cancer jumps to about 350 cases per 100,000 people. This rate almost triples to 1,000 cases per 100,000 in people 60 and above. Nevertheless, researchers now notice a concerning trend—a rise in the number of cancer cases being diagnosed in young adults, especially those below 50.

A new research by the NCI shows an in-depth analysis of early-onset cancers in the US. The research, which spanned over 2 million cases diagnosed between 2010 and 2019, revealed substantial increases in certain forms of cancer among younger individuals. Breast, colorectal, kidney, and uterine cancers were identified as the top drivers of this increase. Of the 33 cancers examined, 14 had increasing rates in at least one younger age group, with 63% of these early-onset cancers being in women.

The NCI's report compared cancer incidence in 2019 with what could have been anticipated from the rates in 2010. The results are worrisome:

Breast Cancer: The biggest proportion of the increase was seen in breast cancer, with approximately 4,800 extra cases in young adults compared to what could have been anticipated.

Colorectal Cancer: There were 2,000 more than anticipated cases of colorectal cancer.

Kidney Cancer: 1,800 more cases of kidney cancer were diagnosed.

Uterine Cancer: Uterine cancer diagnoses went up by 1,200 cases.

Interestingly, even as the diagnosis is on the increase, the mortality rates for the majority of cancers among young people have not actually increased. There were, however, sharp increases in the mortality rates for colorectal, uterine, and testicular cancers among the young population.

Why Is This Happening?

The causes of this rise in early-onset cancer are multifaceted and complex. Although more study is required, a number of theories have been put forward by specialists in the field:

Obesity: Obesity has been associated with a heightened risk of various cancers, including uterine and colorectal cancers, for many years. As obesity continues to increase, it could account for some of the rises in cancer diagnoses among young individuals.

Advances in Detection of Cancer: Enhanced screening techniques and shifts in guidelines for early detection may be contributing. These advances have resulted in increasing numbers of cancers being detected at an earlier stage, which may be contributing to the increase in diagnoses.

Delayed Childbearing: For women, delayed childbearing is linked with an increased risk of breast cancer. Pregnancy and lactation have been shown to decrease the risk of breast cancer, therefore delayed pregnancies might be adding to the increase in cases among younger women.

Environmental and Lifestyle Factors: Greater exposure to carcinogens, either through pollution, chemicals, or lifestyle choices, may also be affecting cancer rates among young people.

What Kinds of Cancer Are Increasing?

While the rate of cancer for some cancers in older individuals is decreasing, young people are experiencing more cases of certain cancers. The greatest increases have been seen in the following:

Breast Cancer

This cancer is among the most prevalent cancers of younger women, especially those under the age of 50. A concerning trend that has been seen is an increase in more aggressive subtypes of breast cancer, including triple-negative and HER2-positive breast cancers. These cancers are harder to treat and have poorer prognoses.

Colorectal Cancer

Previously viewed as a disease of predominantly older individuals, colorectal cancer is becoming more prevalent among young people. Early-onset colorectal cancer is specifically of concern because it is often diagnosed at later stages when it is more difficult to treat.

Uterine Cancer

This form of cancer is increasingly found in younger women. Similar to colorectal cancer, the increasing uterine cancer may be a result of the escalating obesity epidemic.

Kidney Cancer

Kidney cancer diagnoses have similarly increased in young adults. While the causes of this are unknown, it is believed that obesity and other lifestyle-related issues may be to blame.

Are Some Cancers Are Decreasing Too?

While there has been an increase in early-onset cancers, it must be added that cancer incidence is falling for various forms in younger age groups. The most significant falls have been observed in lung cancer and prostate cancer.

Lung Cancer: The decrease in lung cancer is, in large part, due to the substantial reduction in cigarette smoking prevalence during the last decades. This has resulted in a commensurate reduction in the incidence of young adults with lung cancer.

Prostate Cancer: The reduction in prostate cancer incidence can be attributed to revised screening recommendations that discourage the routine use of prostate-specific antigen (PSA) testing in young men. This has lowered the rate of unnecessary diagnoses and treatments.

How Are Early-Onset Cancers Different?

The most glaring distinction between early-onset cancers and those that are diagnosed later in life is age. Yet, the aggressiveness of some cancers, particularly breast cancer, is a major consideration. Younger patients tend to have more aggressive types of cancer, which tend to be treated with more aggressive and invasive therapies.

In breast cancer, for instance, younger women will tend to carry genetically caused cancers, like the ones related to BRCA mutation. But again, these genes only explain only 20% of early-onset breast cancer, which points to other genetic or environmental exposures as well.

Can Early-Onset Cancer Be Prevented?

Although it is not possible for anybody to avoid the risk of cancer entirely, some lifestyle choices will minimize the chance of cancer occurrence. According to experts, they include the following:

• Physical activity can lower the risk of developing many cancers, including breast and colon cancer.
• A balanced diet with plenty of fruits, vegetables, and whole grains can reduce the risk of cancer. Reducing processed foods and alcohol consumption is also helpful.
• Smoking is a major cause of cancer, especially lung cancer. Stopping smoking at any age can lower the risk substantially.
• If there is a family history of cancer, it is critical to bring this up with your physician. Genetic counseling and ongoing screening may help detect cancers at an earlier stage, when they are more treatable.
• Early awareness of cancer signs and symptoms is key. Regular check-ups and screenings, like mammograms and colonoscopies, can detect cancers before they become problematic, enhancing the potential for effective treatment.

Although the increase in early-onset cancers is distressing, it is also an urgent call for more research. Researchers need to work towards establishing the root cause of this surge, especially for cancers such as breast, colorectal, and uterine cancers. Through the discovery of the drivers behind these trends, we can then create better prevention methods and treatment options, improving the prognosis of younger cancer patients.

The growing number of cancers occurring before the age of 50 is an important public health issue that must be addressed now. Although certain cancers are decreasing, others are increasing, and it is imperative to keep monitoring and studying these trends to promote a healthier tomorrow for everyone.

An 18-year-old Sreenanda from Kerala, India, died after months of adhering to a radical water-only diet based on videos from YouTube. Her treating doctor, Dr. Nagesh Prabhu, said the teenager had anorexia nervosa, a serious eating disorder, which went un-diagnosed and un-treated until it was too late.

Despite having been put on a ventilator during her last days, the extended deprivation of nutrients had already done its permanent damage- malnourishment, a significantly reduced stomach and esophagus, and near-critically low sodium and blood sugar levels that were impossible to correct through medicine.

This tragedy is not only a local news item. It is symptomatic of a spreading, international public health and mental health issue—how eating disorders such as anorexia are misperceived, dismissed, and compounded by online misinformation and social pressure.

What Is Anorexia Nervosa?

Anorexia nervosa is not just a diet that has gotten out of control—it is a severe mental illness with potentially life-threatening results. People with anorexia usually develop a distorted view of their body and an extreme fear of gaining weight, even when they are underweight or starving. This psychological disorder results in restrictive eating habits, compulsive behavior regarding food and exercise, and, in most instances, the refusal to accept the seriousness of their health.

It impacts both males and females, although it is more common in teenagers, who are more likely to be subject to peer pressure, social media ideals of beauty, and emotional instability during their teen years.

Dr. Prabhu discovered that Sreenanda had started displaying signs of extreme food restriction some six months prior to her death. Her family, however, misunderstood her condition and dismissed it as a characteristic of a typical adolescent. As with most others who suffer from anorexia, she had learned to conceal the severity of the illness.

"Eventually, patients lose the sensation of hunger," explained Dr. Prabhu. "Her sugar and sodium levels had dropped to levels that were uncorrectable. She was starving almost." Compounding the issue was the reach of untested diet content from YouTube, which misledly promoted water fasting as a fast and safe method for weight loss.

This misinformation cost Sreenanda her life—and highlights the risk of unmonitored diets and the need for mental health education surrounding eating disorders.

Symptoms That Should Never Be Ignored

The indications of anorexia are more than physical—they're behavioral and emotional. Symptoms include:

• Severe weight loss or inability to gain expected weight.
• Fatigue, dizziness, and intolerance to cold.
• Swelling of limbs, stomachaches, constipation.
• Insomnia, irritability, and mood swings.
• Obsessive food behaviors—such as skipping meals, eating exclusively "safe" foods, or exercising compulsively.
• Low self-esteem, social isolation, and a strong fear of gaining weight.
• In women, cessation of menstrual periods without the use of birth control.

If the body is starved, brain function also breaks down, making it more difficult for people to realize the extent of their malady. This usually brings with it refusal to seek treatment and an even more precipitous decline.

What are the Risks of Anorexia?

The medical effects of anorexia extend far beyond being underweight. Chronic malnourishment can lead to:

• Anemia
• Bone thinning and bone fractures
• Kidney and liver failure
• Irrregular or slowed heart rate
• Low blood pressure
• Multi-organ failure
• Brain atrophy
• Death from heart-related complications or suicide

As reported by the National Association of Anorexia Nervosa and Associated Disorders (ANAD), anorexia has the second-highest death rate among all mental disorders, only beat by opioid dependence. Eating disorders kill over 10,000 people annually in the U.S., and suicide accounts for 24% of deaths related to anorexia.

Anorexia, when detected and addressed early, is controllable and even reversible through appropriate intervention consisting of nutritional rehabilitation, medical attention, and psychotherapy. The disorder, though, being of a specific kind, means many of its sufferers do not respond to it being addressed. They deny illness, think they remain overweight, or are afraid treatment will compel them to become obese.

Family, teachers, and friends are important in recognizing early warning signs and stimulating prompt medical assistance. Procrastination can be lethal.

Can Anorexia Be Prevented?

Although anorexia cannot be prevented with certainty, professionals concur that encouraging healthy food attitudes, body image, and self-esteem in early life will substantially lessen the risk. This entails:

• Promoting activities and accomplishments unrelated to looks.
• Practicing balanced eating and positive body image within the home.
• Reducing exposure to negative or unattainable beauty standards on the internet.
• Being wary of diet or health fads on social media sites.

In Sreenanda's case, it was a mixture of web misinformation, unresolved mental health issues, and failure of early intervention that led to her death. Her tale serves as a graphic reminder that eating disorders are no phase or a choice of lifestyle—these are life-threatening conditions that need specialized attention.

If you or someone you know is experiencing an eating disorder, get help now. Recovery is possible—with care, understanding, and prompt action.