The global challenge of HIV/AIDS remains one of the most pressing public health issues today. According to the latest data from UNAIDS, around 38.4 million people worldwide are living with HIV/AIDS, underlining the need for not only medical intervention but also comprehensive awareness, education, and social change. Despite the significant strides made in treatment and prevention, the confusion surrounding the relationship between HIV and AIDS still persists.

Young people have become influential advocates in the fight against HIV/AIDS. Research from UNICEF shows that youth-led initiatives can lower HIV transmission rates by as much as 45% in targeted communities. These young activists utilize digital platforms and peer-to-peer education to dispel myths, promote safe practices, and foster supportive environments for those affected by HIV/AIDS.

Dr Gowri Kulkarni, an expert in Internal Medicine, explains that while the terms HIV and AIDS are often used interchangeably, they are distinctly different. "HIV (Human Immunodeficiency Virus) is a virus that attacks the immune system, whereas AIDS (Acquired Immunodeficiency Syndrome) is a condition that occurs when HIV severely damages the immune system," she clarifies. To understand the implications of these differences, it's important to explore the fundamental distinctions between the two.

1. HIV is a Virus; AIDS is a Syndrome

HIV is the virus responsible for attacking the body’s immune system, specifically targeting CD4 cells, which are crucial for the body’s defense against infections. As HIV progresses, it destroys these cells, weakening the immune system over time. If left untreated, this continuous damage can lead to AIDS.

AIDS, on the other hand, is a syndrome, not a virus. Dr Kulkarni further elaborates that AIDS is a collection of symptoms and illnesses that emerge when the immune system is severely compromised due to prolonged HIV infection. It represents the most advanced stage of HIV, and is characterized by very low CD4 counts or the onset of opportunistic infections like tuberculosis, pneumonia, or certain cancers.

2. Not Everyone with HIV Develops AIDS

A key distinction to remember is that not everyone with HIV will progress to AIDS. Thanks to advancements in medicine, particularly antiretroviral therapy (ART), individuals living with HIV can manage the virus and maintain a healthy immune system for many years, or even decades, without ever developing AIDS. ART works by suppressing the virus to undetectable levels, effectively preventing the damage HIV would otherwise cause to the immune system.

Without treatment, however, HIV progresses through three stages:

- Acute HIV Infection: This stage occurs shortly after transmission and may include symptoms like fever, fatigue, and swollen lymph nodes.

- Chronic HIV Infection: Often asymptomatic or mildly symptomatic, the virus continues to damage the immune system but at a slower rate.

- AIDS: This is the final stage, marked by severe immune damage and the presence of infections that take advantage of the compromised immune defenses.

3. HIV is Transmissible; AIDS is Not

Another key distinction between HIV and AIDS is the way in which they are transmitted. HIV is highly contagious and can be transmitted through the exchange of bodily fluids such as blood, semen, vaginal fluids, and breast milk. It is primarily spread through unprotected sexual contact, sharing needles, or from mother to child during childbirth or breastfeeding.

AIDS, however, is not transmissible. It is not a disease that can be passed from one person to another. Rather, AIDS is the result of untreated, advanced HIV infection and is a direct consequence of the virus’s damage to the immune system.

4. Diagnosis Methods Differ

HIV and AIDS are diagnosed through different methods. HIV is diagnosed through blood tests or oral swabs that detect the presence of the virus or antibodies produced by the immune system in response to the virus. Early detection of HIV is crucial, as it allows for timely intervention and treatment, which can prevent the virus from progressing to AIDS.

AIDS, on the other hand, is diagnosed using more specific criteria. Dr Kulkarni notes that the diagnosis of AIDS is made when the individual’s CD4 cell count falls below 200 cells/mm³, or when opportunistic infections or certain cancers (such as Kaposi's sarcoma or lymphoma) are detected. Diagnosing AIDS involves a more thorough assessment of the individual’s immune function and overall health, as opposed to just the detection of HIV.

5. Treatment Goals Are Different

The treatment goals for HIV and AIDS differ significantly, although both involve antiretroviral therapy (ART). For HIV, the primary treatment goal is to suppress the virus to undetectable levels, thus maintaining a strong immune system and preventing further transmission of the virus. People living with HIV can often live long, healthy lives if they adhere to ART.

For individuals diagnosed with AIDS, the treatment plan becomes more complex. While ART remains an essential part of managing the virus, treatment for AIDS also focuses on addressing the opportunistic infections and secondary health complications associated with severe immune suppression. The goal of treatment for AIDS is not only to manage the HIV virus but also to improve the quality of life and extend survival by treating these secondary health issues.

Role of Community Engagement in Combatting HIV/AIDS

While the medical community has made great strides in managing HIV, the battle to curb its transmission is also a social and cultural issue. Dr Daman Ahuja, a public health expert, highlights that HIV/AIDS awareness and education are vital to reducing transmission rates and supporting those affected by the virus. "Young people, especially, have become key advocates in the fight against HIV/AIDS," says Dr Ahuja. "Research from UNICEF shows that youth-led initiatives can lower HIV transmission rates by as much as 45% in targeted communities."

Additionally, grassroots activism plays a significant role in raising awareness and addressing stigma. As the World Health Organization reports, community-based interventions have been proven to increase HIV testing rates and improve treatment adherence, which are crucial in the fight against the pandemic.

The ultimate goal of organizations like UNAIDS is to eliminate the HIV/AIDS pandemic by 2030. Achieving this requires global collaboration, from medical treatment advancements to public health strategies, education, and advocacy. Dr Kulkarni’s insight underscores the importance of early detection, treatment adherence, and community support in the fight against HIV/AIDS.

Dr Gowri Kulkarni is Head of Medical Operations at MediBuddy and Dr Daman Ahuja, a public health expert and has been associated with Red Ribbon Express Project of NACO between 2007-12.

Norovirus, often called the “stomach flu” or “winter vomiting illness,” is currently circulating in California and across the United States. Health experts say proper cleaning and disinfecting can slow its spread. These precautions matter because norovirus is extremely contagious and there is no specific treatment for it, according to the Centers for Disease Control and Prevention.

Between August 1 and November 13, health officials recorded 153 norovirus outbreaks across 14 states. The CDC defines an outbreak as two or more similar illnesses linked to suspected or lab-confirmed norovirus cases. Although California is not among the states reporting outbreaks, CDC data shows a noticeable rise in positive norovirus tests throughout November across the western US.

What Is Norovirus?

Norovirus is described as a “highly contagious” virus that causes vomiting, diarrhea, and stomach cramps, according to the California Department of Public Health. It leads to acute gastroenteritis, which means inflammation of the stomach or intestines, and affects people of all ages, the CDC said.

Despite its nickname, norovirus has nothing to do with influenza. The flu is caused by the influenza virus, not norovirus, the agency clarified.

Winter Vomiting Disease: How Does The Stomach Bug Spread?

Norovirus spreads easily from person to person, especially while someone is actively sick, according to the California Department of Public Health. Symptoms usually last one to three days, but a person can still spread the virus for up to two days after they start feeling better.

The virus is present in vomit and stool and can spray into the air or settle on nearby surfaces. It can survive for weeks on uncleaned items such as countertops, phones, and doorknobs, the department said.

“You can get sick after touching or caring for someone who is sick, or after touching or eating something that is contaminated,” the department noted.

Norovirus spreads quickly in crowded or enclosed settings, including schools, child care facilities, hospitals, nursing homes, jails, and cruise ships.

According to state and federal health officials, the most common ways people catch norovirus include:

• Touching, caring for, or sharing food with someone who has norovirus
• Eating or drinking contaminated food or beverages, including undercooked shellfish like oysters
• Touching a contaminated surface and then touching your mouth before washing your hands
• Sharing a toilet or bathroom with someone who is sick
• Swallowing contaminated water, including water from swimming pools or recreational areas
• Cleaning up vomit or diarrhea without protective gear, such as gloves or a face mask

Do You Need To Disinfect After Norovirus?

“If you or someone in your household has norovirus, it’s important to clean and disinfect areas where vomiting or diarrhea occurred,” the California Department of Public Health advised. Cleaning with soap and water removes germs, while disinfecting kills those that remain.

You can use commercial disinfectants, but it’s important to read the label and make sure norovirus is listed among the germs it targets. You can also check the Environmental Protection Agency’s registration number and confirm it appears on the EPA’s List G, which includes products proven effective against norovirus.

Another option is making a bleach solution at home. The US Department of Agriculture recommends mixing 5 to 25 tablespoons of household bleach with one gallon of water. This solution should be used only on hard or nonporous surfaces and applied with a spray bottle or disposable mop, sponge, or paper towel. Let it sit for about five minutes before wiping it away.

The USDA also advises paying close attention to frequently touched items such as doorknobs, handles, and remote controls. Many disinfectant wipes do not fully kill norovirus, the agency warned.

How To Disinfect After Norovirus?

The CDC recommends wearing rubber or disposable gloves while cleaning. Use paper towels to wipe the affected area completely, then place the towels in a plastic trash bag. The California Department of Public Health also suggests wearing a face mask.

After disinfecting, clean the area again with soap and water, the CDC said. Keep in mind that vomit can aerosolize the virus, meaning surfaces several feet away may also be contaminated, according to the USDA.

Once you’re done, throw away the gloves and mask, then take out the trash, the California Department of Public Health advised.

Millions of people across the UK who take certain everyday medicines are being warned by the NHS to steer clear of a specific fruit. Health officials say combining this fruit or its juice with some medications can trigger serious reactions and unexpected side effects. The advice applies to patients prescribed some of the most commonly used drugs in the country, including certain statins, amlodipine, and medicines for anxiety. Statins, in particular, are widely prescribed to help reduce levels of “bad” LDL cholesterol in the blood.

Why Statins Are Commonly Prescribed?

Statins work by limiting how much cholesterol the liver makes. This helps slow down the build-up of fatty deposits inside the arteries, which in turn lowers the risk of heart attacks and strokes. Doctors prescribe statins both to manage high cholesterol and to prevent future heart-related problems. For most people, they are taken daily as tablets and are often part of long-term treatment.

What Does Amlodipine Do?

Amlodipine, commonly sold under the brand name Istin, belongs to a group of medicines known as calcium channel blockers. It is mainly used to treat high blood pressure. For people with hypertension, amlodipine can reduce strain on the heart and lower the risk of serious complications such as heart disease, heart attacks, and strokes.

NHS Warning On Statins Or Amlodipine

Patients taking certain forms of amlodipine, particularly calcium channel blockers, are advised not to consume grapefruit. The NHS website clearly states: “Do not take amlodipine with grapefruit juice.”

The reason lies in how grapefruit affects the body. It interferes with enzymes and transport proteins in the gut, such as CYP3A4 and P-gp, which normally help break down medicines and control how much enters the bloodstream. When these processes are blocked, higher-than-intended amounts of the drug can build up in the body, increasing the risk of side effects.

What Patients Should Keep In Mind

Not every medicine reacts the same way to grapefruit juice, which is why doctors advise checking before making changes. Always speak to your GP or pharmacist, read the information leaflet that comes with your medicine, and look out for any warnings related to grapefruit.

It is also important to understand that simply spacing the fruit and the medicine apart is not enough. In most cases, grapefruit should be avoided entirely for as long as you are on the medication, unless your doctor says otherwise. Patients are also encouraged to be cautious with other citrus fruits, such as Seville oranges, pomelos, and limes, as they can have similar effects on how medicines work.

What To Do If You’ve Already Consumed It?

If you have eaten grapefruit or had its juice while taking statins, amlodipine, or anti-anxiety medication, there is no need to panic. In many cases, a single exposure does not lead to serious harm, but it is important to stay alert. Pay attention to how your body feels over the next day or two, especially if you notice symptoms such as dizziness, muscle pain, unusual tiredness, nausea, flushing, or a sudden drop in blood pressure.

Do not stop taking your medication on your own. Skipping doses or stopping treatment abruptly can be risky, particularly for heart and blood pressure medicines. Instead, make a note of what you consumed and when, and contact your GP or pharmacist for advice. They can tell you whether any action is needed based on the specific drug, dose, and your overall health.

During the festive months, overindulgence in celebrations can trigger holiday heart syndrome (HHS), a potentially serious yet largely preventable set of heart-related symptoms that tend to rise during this time of year. Most people recover within a day, but HHS can occasionally lead to stroke, heart attack, or other serious complications, according to the Cleveland Clinic. As the holiday season approaches, let’s explore what holiday heart syndrome is, its symptoms, and how to prevent it.

What Is Holiday Heart Syndrome?

First identified by a US physician in 1978, holiday heart syndrome describes irregular heartbeats that occur after binge drinking during the festive season. Research from the University of South Australia shows that alcohol consumption increases by 70 per cent in December compared to other months, while iSelect data predicts Australians may consume around 58 million standard drinks per day during the month. With numbers like these, some caution is warranted.

Atrial fibrillation (AFib) is the specific irregular heartbeat seen in HHS. It occurs when the heart’s upper chambers contract or quiver in a chaotic pattern, which can cause blood to pool in the atrium and form clots. If these clots enter the bloodstream, they can travel to the brain and trigger a stroke.

What Are the Symptoms of Holiday Heart?

Symptoms can include fatigue, dizziness, shortness of breath, anxiety, weakness, confusion, sweating, faintness, unusual tiredness during exercise, rapid or irregular heartbeat, and sensations like fluttering, thumping, pressure, or chest pain.

Dr Mariann R. Piano, Nancy and Hilliard Travis Professor of Nursing at Vanderbilt University School of Nursing, warns, “The scary thing is that people may not notice any symptoms, which makes it a particularly dangerous arrhythmia.”

How Can Drinking Lead to AFib?

Researchers are still investigating exactly how alcohol triggers AFib and how much intake increases the risk. A 2020 study found that people who usually drank at least 10 alcoholic beverages a week lowered their risk of holiday heart syndrome by reducing alcohol consumption. Another study confirmed that eliminating alcohol significantly decreases the chances of developing AFib.

How To Try to Avoid Holiday Heart Syndrome

The Australian Alcohol Guidelines recommend that healthy adults limit alcohol to no more than 10 standard drinks per week to reduce risk.

Experts like Kistler suggest that people with existing heart arrhythmias either abstain or stick to “up to three standard drinks a week.” Drinking mindfully, reducing overall consumption, and staying well hydrated can also help protect your heart.

Tips To Keep Your Heart Healthy During Holidays

• Eat smaller, balanced meals and avoid heavy late-night feasts.
• Limit alcohol intake and stay hydrated.
• Continue regular medications without interruption.
• Stay warm and avoid sudden exposure to cold temperatures.
• Maintain light physical activity and avoid strenuous exertion in the early morning.
• Manage stress by taking breaks, sleeping adequately, and avoiding overexertion during travel or celebrations.
• Seek medical help immediately if you experience chest discomfort, unusual fatigue, breathlessness, or palpitations.