The global challenge of HIV/AIDS remains one of the most pressing public health issues today. According to the latest data from UNAIDS, around 38.4 million people worldwide are living with HIV/AIDS, underlining the need for not only medical intervention but also comprehensive awareness, education, and social change. Despite the significant strides made in treatment and prevention, the confusion surrounding the relationship between HIV and AIDS still persists.

Young people have become influential advocates in the fight against HIV/AIDS. Research from UNICEF shows that youth-led initiatives can lower HIV transmission rates by as much as 45% in targeted communities. These young activists utilize digital platforms and peer-to-peer education to dispel myths, promote safe practices, and foster supportive environments for those affected by HIV/AIDS.

Dr Gowri Kulkarni, an expert in Internal Medicine, explains that while the terms HIV and AIDS are often used interchangeably, they are distinctly different. "HIV (Human Immunodeficiency Virus) is a virus that attacks the immune system, whereas AIDS (Acquired Immunodeficiency Syndrome) is a condition that occurs when HIV severely damages the immune system," she clarifies. To understand the implications of these differences, it's important to explore the fundamental distinctions between the two.

1. HIV is a Virus; AIDS is a Syndrome

HIV is the virus responsible for attacking the body’s immune system, specifically targeting CD4 cells, which are crucial for the body’s defense against infections. As HIV progresses, it destroys these cells, weakening the immune system over time. If left untreated, this continuous damage can lead to AIDS.

AIDS, on the other hand, is a syndrome, not a virus. Dr Kulkarni further elaborates that AIDS is a collection of symptoms and illnesses that emerge when the immune system is severely compromised due to prolonged HIV infection. It represents the most advanced stage of HIV, and is characterized by very low CD4 counts or the onset of opportunistic infections like tuberculosis, pneumonia, or certain cancers.

2. Not Everyone with HIV Develops AIDS

A key distinction to remember is that not everyone with HIV will progress to AIDS. Thanks to advancements in medicine, particularly antiretroviral therapy (ART), individuals living with HIV can manage the virus and maintain a healthy immune system for many years, or even decades, without ever developing AIDS. ART works by suppressing the virus to undetectable levels, effectively preventing the damage HIV would otherwise cause to the immune system.

Without treatment, however, HIV progresses through three stages:

- Acute HIV Infection: This stage occurs shortly after transmission and may include symptoms like fever, fatigue, and swollen lymph nodes.

- Chronic HIV Infection: Often asymptomatic or mildly symptomatic, the virus continues to damage the immune system but at a slower rate.

- AIDS: This is the final stage, marked by severe immune damage and the presence of infections that take advantage of the compromised immune defenses.

3. HIV is Transmissible; AIDS is Not

Another key distinction between HIV and AIDS is the way in which they are transmitted. HIV is highly contagious and can be transmitted through the exchange of bodily fluids such as blood, semen, vaginal fluids, and breast milk. It is primarily spread through unprotected sexual contact, sharing needles, or from mother to child during childbirth or breastfeeding.

AIDS, however, is not transmissible. It is not a disease that can be passed from one person to another. Rather, AIDS is the result of untreated, advanced HIV infection and is a direct consequence of the virus’s damage to the immune system.

4. Diagnosis Methods Differ

HIV and AIDS are diagnosed through different methods. HIV is diagnosed through blood tests or oral swabs that detect the presence of the virus or antibodies produced by the immune system in response to the virus. Early detection of HIV is crucial, as it allows for timely intervention and treatment, which can prevent the virus from progressing to AIDS.

AIDS, on the other hand, is diagnosed using more specific criteria. Dr Kulkarni notes that the diagnosis of AIDS is made when the individual’s CD4 cell count falls below 200 cells/mm³, or when opportunistic infections or certain cancers (such as Kaposi's sarcoma or lymphoma) are detected. Diagnosing AIDS involves a more thorough assessment of the individual’s immune function and overall health, as opposed to just the detection of HIV.

5. Treatment Goals Are Different

The treatment goals for HIV and AIDS differ significantly, although both involve antiretroviral therapy (ART). For HIV, the primary treatment goal is to suppress the virus to undetectable levels, thus maintaining a strong immune system and preventing further transmission of the virus. People living with HIV can often live long, healthy lives if they adhere to ART.

For individuals diagnosed with AIDS, the treatment plan becomes more complex. While ART remains an essential part of managing the virus, treatment for AIDS also focuses on addressing the opportunistic infections and secondary health complications associated with severe immune suppression. The goal of treatment for AIDS is not only to manage the HIV virus but also to improve the quality of life and extend survival by treating these secondary health issues.

Role of Community Engagement in Combatting HIV/AIDS

While the medical community has made great strides in managing HIV, the battle to curb its transmission is also a social and cultural issue. Dr Daman Ahuja, a public health expert, highlights that HIV/AIDS awareness and education are vital to reducing transmission rates and supporting those affected by the virus. "Young people, especially, have become key advocates in the fight against HIV/AIDS," says Dr Ahuja. "Research from UNICEF shows that youth-led initiatives can lower HIV transmission rates by as much as 45% in targeted communities."

Additionally, grassroots activism plays a significant role in raising awareness and addressing stigma. As the World Health Organization reports, community-based interventions have been proven to increase HIV testing rates and improve treatment adherence, which are crucial in the fight against the pandemic.

The ultimate goal of organizations like UNAIDS is to eliminate the HIV/AIDS pandemic by 2030. Achieving this requires global collaboration, from medical treatment advancements to public health strategies, education, and advocacy. Dr Kulkarni’s insight underscores the importance of early detection, treatment adherence, and community support in the fight against HIV/AIDS.

Dr Gowri Kulkarni is Head of Medical Operations at MediBuddy and Dr Daman Ahuja, a public health expert and has been associated with Red Ribbon Express Project of NACO between 2007-12.

Breast cancer is the most frequently diagnosed cancer in women, accounting for over 15% of all new cancer cases in the United States. Abnormal cell growth in the breast ducts (DCIS) or lobules (LCIS) can sometimes progress to breast cancer, but currently, doctors cannot predict which cases will develop into invasive cancer.

A recent retrospective study using the 313-SNP breast cancer polygenic risk score (PRS313) blood test suggests that women with abnormal cells are more likely to be diagnosed with breast cancer later on. This discovery could help identify patients who would benefit from targeted interventions while reducing unnecessary treatments.

Although DCIS and LCIS can progress to breast cancer, predicting which cases will remain harmless has been a challenge. However, this new study indicates that calculating a polygenic score may help forecast a future breast cancer diagnosis.

“It is therefore very important that we find ways to predict which women with DCIS and LCIS are most likely to develop invasive breast cancer in the future so they can be given the most appropriate treatment and avoid unnecessary treatment,” explained study senior author Elinor J. Sawyer of King’s College London (UK).

What Is A Polygenic Score?

A polygenic score is a numerical estimate of a person’s genetic likelihood of developing a particular trait or disease. When used to predict disease risk, it is often called a polygenic risk score (PRS), according to Harvard Medicine Magazine.

Sawyer and study lead author Jasmine Timbres (King’s College London) focused on PRS313, a blood test that evaluates breast cancer risk by identifying which of 313 specific genetic variations (single nucleotide polymorphisms, or SNPs) a person carries. The researchers examined PRS313 scores from more than 2,000 DCIS and LCIS cases across the ICICLE and GLACIER studies.

Their findings showed that, for DCIS, women with higher PRS313 scores were 2.03 times more likely to develop cancer in the opposite breast compared to those in the lowest score quartile. For LCIS, women with elevated PRS313 scores were 2.16 times more likely to develop cancer in the same breast. The risk was even higher for patients with a family history of breast cancer.

“LCIS is not always treated with surgery or hormone therapy because it is considered lower risk than DCIS. However, these results suggest that women with a family history may benefit from additional interventions to reduce their risk of developing cancer,” Timbres added.

How To Measure A Polygenic Score?

A polygenic score is calculated by looking at an individual’s genetic variations (like SNPs) and summing them with weights based on how strongly each variant is associated with a trait or disease, as determined by large-scale genome-wide association studies (GWAS). Researchers first identify genetic variants linked to a disease by comparing the genomes of people with and without the condition. Each variant’s effect size is then applied to the individual’s genome to create a single score representing their overall genetic risk.

Polygenic scores can be measured in research settings using GWAS data. They are also available through commercial direct-to-consumer genetic testing services or via clinical assessments provided by medical institutions and genetic counselors.

Limitations Of The Study

While these findings are promising, further research is needed to confirm results in other patient groups and to examine additional genetic factors. Some limitations include the fact that PRS313 was designed specifically to assess risk for invasive breast cancer, meaning it may not capture other relevant genetic changes in in-situ breast disease. Additionally, the number of women with LCIS in the study was relatively small, which may have limited the ability to detect statistically significant associations.

Days before Diwali celebrations took off, the national capital of India, Delhi has already logged 211 in the Air Quality Index (AQI), categorizing the quality as ‘Poor’. The Central Air Quality Management (CAQM), as a result, imposed Stage 1 measures under the Graded Response Action Plan (GRAP) across Delhi-NCR, which will ensure dust control measures, including the use of anti-smog guns around the construction and demolition sites and areas with higher AQI.

As Delhi prepares itself for Diwali, this year, the Supreme Court of India allowed the sale and bursting of green firecrackers in the city, after lifting last year’s blanket ban on all crackers.

The Supreme Court permitted the sale between October 18 and 21 and limited the timings to 6-7am and 8-10pm.The Chief Justice of India Bhushan R Gavai said, “We have to take a balanced approach permitting it in moderation while not compromising with the environment.”

However, what one needs to understand is whether green crackers really work for the environment.

Are Green Crackers Also Health Threats?

While it is true that green crackers are designed to cut emissions of particulate matter and harmful gases by 30 to 40% and keep the noise levels below 120 decibels, a joint study by Delhi Technological University (DTU) and IIT Roorkee shows that even green crackers release large volumes of ultrafine particles. These particles are smaller than 100 nanometers and can penetrate deep into the lungs.

Dr Rajeev Kumar Mishra, who is the senior researcher at DTU as reported by The Indian Express, said that more research must be done to assess atmospheric emissions of green crackers and their health impacts.

These small particles present in the green crackers can also become a hinder for people with existing pulmonary and respiratory issues, asthma, COPD, and heart problems.

Green crackers also emit fine and ultrafine particles like PM2.5 and PM1, and they are tiny enough to go deep in the lungs and even enter the blood streams. These tiny particles also contain small amounts of metals and chemicals which can cause breathing problems or worsen the issues in people with existing breathing problems.

Many experts also note that green crackers, while producing less sound, still exceed safe auditory limits. It can also cause relentless or disturbed sleep.

What Are The Health Risks?

As per the World Health Organization (WHO), air pollution can lead to stroke, ischaemic heart disease, CPOD, lung cancer, pneumonia, and cataracts.

Dr Sanjay Jain, a Delhi-based ENT and a member of DocTube also noted an increase in the number of patients with respiratory issues. "I have seen a notable increase in patients with upper respiratory tract infections, chronic sinusitis, and allergic rhinitis, which are directly linked to rising pollution levels," he says. From his experience, he has noticed a rough increase of 30 to 40% of patients with pollution-related ENT issues.

Dr Jain says that prolonged exposure to pollution can cause chronic ear infections in children due to inflammation in the Eustachian tube. "This is not commonly recognized by people," he says.

The act of burning firecrackers emits harmful and toxic gases such as carbon monoxide, which facilitate air pollution. This can cause health problems including skin irritation, respiratory issues, cancer, and asthma.

When Diwali comes near, every Indian household gets into full cleaning mode. The week leading up to the festival is usually spent sweeping, scrubbing, and dusting every corner of the home. While this ritual is believed to invite prosperity, it can also have some hidden problem, dust mite allergy.

If you start sneezing uncontrollably, coughing, or notice a runny nose while cleaning, chances are you are reacting to dust mites. But how serious can this allergy get? Let’s understand.

What Is Dust Mite Allergy?

Dust mite allergy, also called house dust allergy, happens when your immune system becomes sensitive to the droppings and remains of microscopic dust mites. These tiny, spider-like organisms live in bedding, mattresses, carpets, curtains, and furniture, feeding on dead skin cells shed by humans and pets.

According to the Cleveland Clinic, dust mite waste and dead bodies contain certain proteins that act as allergens. While these proteins are harmless to most people, some immune systems mistake them for dangerous invaders and trigger allergic reactions such as sneezing, asthma, itching, or eczema.

Can Dust Mite Allergy Trigger More Chronic Diseases?

Yes, a dust mite allergy can worsen over time and contribute to chronic conditions. The National Institutes of Health states that long-term exposure can lead to diseases like asthma and chronic sinusitis due to persistent inflammation.

Here are some chronic diseases linked to dust mite allergy:

• Asthma: Dust mite allergens are one of the main causes of asthma and can provoke severe attacks. Ongoing inflammation may make the airways overly sensitive and lead to permanent changes in lung tissue.
• Chronic sinusitis: Continuous exposure can inflame and swell the nasal passages, resulting in long-term sinus blockage and infections.
• Atopic dermatitis (Eczema): Though not a chronic disease itself, eczema can be made worse by dust mites, causing persistent irritation.

Why it can lead to chronic disease:

• Chronic inflammation: The immune system’s response to dust mites inflames the nasal passages and lungs. Prolonged exposure keeps this inflammation active, gradually damaging tissues.
• Increased sensitivity: Constant inflammation heightens sensitivity to smoke, pollution, or dry air, making symptoms more intense.
• The “atopic march”: This term describes the way allergic conditions can evolve, for example, eczema in childhood developing into asthma or allergic rhinitis later, often linked to dust mite sensitivity.

How Can Dust Mite Allergy Affect Your Body?

When your body first encounters dust mite proteins, it creates antibodies known as immunoglobulin E (IgE) to attack what it perceives as harmful allergens. On later exposure, your immune system reacts more strongly, releasing chemicals that trigger symptoms such as sneezing, itching, or congestion.

How To Treat Dust Mite Allergy: How To Stay Safe

The most effective way to manage a dust mite allergy is by reducing your exposure to dust mites. While it is impossible to remove them completely, minimizing contact helps prevent severe reactions. If symptoms appear, consult a doctor for the right medication. Those with asthma, sinusitis, or other chronic respiratory issues should avoid heavy cleaning during Diwali.

Here are some common treatment options available to treat dust-mite allergy. However, please note that you should take these only under the guidance of a medical professional:

• Antihistamines: Help control sneezing, itching, and watery eyes.
• Nasal corticosteroid sprays: Reduce inflammation and ease congestion.

How To Manage Dust Mites While Cleaning For Diwali

A few steps can help control dust mites while keeping your home festive and clean:

• Use an air conditioner or dehumidifier to keep humidity in check.
• Install a high-efficiency particulate air (HEPA) filter.
• Choose washable decorations and clean them regularly.
• Dust using a damp or oiled cloth instead of a dry one.
• Vacuum frequently with a vacuum cleaner that has a HEPA filter.
• Declutter your space to reduce dust buildup.
• Wash curtains and clean upholstered furniture often.
• If possible, replace carpets with wood, tile, vinyl, or linoleum flooring.