The global challenge of HIV/AIDS remains one of the most pressing public health issues today. According to the latest data from UNAIDS, around 38.4 million people worldwide are living with HIV/AIDS, underlining the need for not only medical intervention but also comprehensive awareness, education, and social change. Despite the significant strides made in treatment and prevention, the confusion surrounding the relationship between HIV and AIDS still persists.

Young people have become influential advocates in the fight against HIV/AIDS. Research from UNICEF shows that youth-led initiatives can lower HIV transmission rates by as much as 45% in targeted communities. These young activists utilize digital platforms and peer-to-peer education to dispel myths, promote safe practices, and foster supportive environments for those affected by HIV/AIDS.

Dr Gowri Kulkarni, an expert in Internal Medicine, explains that while the terms HIV and AIDS are often used interchangeably, they are distinctly different. "HIV (Human Immunodeficiency Virus) is a virus that attacks the immune system, whereas AIDS (Acquired Immunodeficiency Syndrome) is a condition that occurs when HIV severely damages the immune system," she clarifies. To understand the implications of these differences, it's important to explore the fundamental distinctions between the two.

1. HIV is a Virus; AIDS is a Syndrome

HIV is the virus responsible for attacking the body’s immune system, specifically targeting CD4 cells, which are crucial for the body’s defense against infections. As HIV progresses, it destroys these cells, weakening the immune system over time. If left untreated, this continuous damage can lead to AIDS.

AIDS, on the other hand, is a syndrome, not a virus. Dr Kulkarni further elaborates that AIDS is a collection of symptoms and illnesses that emerge when the immune system is severely compromised due to prolonged HIV infection. It represents the most advanced stage of HIV, and is characterized by very low CD4 counts or the onset of opportunistic infections like tuberculosis, pneumonia, or certain cancers.

2. Not Everyone with HIV Develops AIDS

A key distinction to remember is that not everyone with HIV will progress to AIDS. Thanks to advancements in medicine, particularly antiretroviral therapy (ART), individuals living with HIV can manage the virus and maintain a healthy immune system for many years, or even decades, without ever developing AIDS. ART works by suppressing the virus to undetectable levels, effectively preventing the damage HIV would otherwise cause to the immune system.

Without treatment, however, HIV progresses through three stages:

- Acute HIV Infection: This stage occurs shortly after transmission and may include symptoms like fever, fatigue, and swollen lymph nodes.

- Chronic HIV Infection: Often asymptomatic or mildly symptomatic, the virus continues to damage the immune system but at a slower rate.

- AIDS: This is the final stage, marked by severe immune damage and the presence of infections that take advantage of the compromised immune defenses.

3. HIV is Transmissible; AIDS is Not

Another key distinction between HIV and AIDS is the way in which they are transmitted. HIV is highly contagious and can be transmitted through the exchange of bodily fluids such as blood, semen, vaginal fluids, and breast milk. It is primarily spread through unprotected sexual contact, sharing needles, or from mother to child during childbirth or breastfeeding.

AIDS, however, is not transmissible. It is not a disease that can be passed from one person to another. Rather, AIDS is the result of untreated, advanced HIV infection and is a direct consequence of the virus’s damage to the immune system.

4. Diagnosis Methods Differ

HIV and AIDS are diagnosed through different methods. HIV is diagnosed through blood tests or oral swabs that detect the presence of the virus or antibodies produced by the immune system in response to the virus. Early detection of HIV is crucial, as it allows for timely intervention and treatment, which can prevent the virus from progressing to AIDS.

AIDS, on the other hand, is diagnosed using more specific criteria. Dr Kulkarni notes that the diagnosis of AIDS is made when the individual’s CD4 cell count falls below 200 cells/mm³, or when opportunistic infections or certain cancers (such as Kaposi's sarcoma or lymphoma) are detected. Diagnosing AIDS involves a more thorough assessment of the individual’s immune function and overall health, as opposed to just the detection of HIV.

5. Treatment Goals Are Different

The treatment goals for HIV and AIDS differ significantly, although both involve antiretroviral therapy (ART). For HIV, the primary treatment goal is to suppress the virus to undetectable levels, thus maintaining a strong immune system and preventing further transmission of the virus. People living with HIV can often live long, healthy lives if they adhere to ART.

For individuals diagnosed with AIDS, the treatment plan becomes more complex. While ART remains an essential part of managing the virus, treatment for AIDS also focuses on addressing the opportunistic infections and secondary health complications associated with severe immune suppression. The goal of treatment for AIDS is not only to manage the HIV virus but also to improve the quality of life and extend survival by treating these secondary health issues.

Role of Community Engagement in Combatting HIV/AIDS

While the medical community has made great strides in managing HIV, the battle to curb its transmission is also a social and cultural issue. Dr Daman Ahuja, a public health expert, highlights that HIV/AIDS awareness and education are vital to reducing transmission rates and supporting those affected by the virus. "Young people, especially, have become key advocates in the fight against HIV/AIDS," says Dr Ahuja. "Research from UNICEF shows that youth-led initiatives can lower HIV transmission rates by as much as 45% in targeted communities."

Additionally, grassroots activism plays a significant role in raising awareness and addressing stigma. As the World Health Organization reports, community-based interventions have been proven to increase HIV testing rates and improve treatment adherence, which are crucial in the fight against the pandemic.

The ultimate goal of organizations like UNAIDS is to eliminate the HIV/AIDS pandemic by 2030. Achieving this requires global collaboration, from medical treatment advancements to public health strategies, education, and advocacy. Dr Kulkarni’s insight underscores the importance of early detection, treatment adherence, and community support in the fight against HIV/AIDS.

Dr Gowri Kulkarni is Head of Medical Operations at MediBuddy and Dr Daman Ahuja, a public health expert and has been associated with Red Ribbon Express Project of NACO between 2007-12.

Alcohol is often seen as harmful mainly for the liver or heart, but its impact goes much deeper—reaching down to our DNA. Even moderate drinking can silently cause changes at a cellular level, raising long-term health risks that may not be immediately visible. According to Dr. Amit Miglani, Director & HOD – Gastroenterology, Asian Hospital, the breakdown of alcohol in the body produces a toxic chemical called acetaldehyde, which can directly damage DNA inside our cells.

Alcohol Can Damage Your DNA, Not Just Your Liver And Heart

This damage disrupts the body’s natural repair mechanisms, allowing mutations to accumulate over time. Such mutations are linked to several cancers, including cancers of the mouth, throat, liver, breast, and colon. The insidious nature of this damage means that even when you feel healthy, harmful changes may be occurring beneath the surface.

How Alcohol Interferes With DNA Repair

DNA damage can be complex to understand, but its consequences are serious, explains Dr. Arun Kumar Giri, Director – Surgical Oncology, Aakash Healthcare. Normally, the body constantly repairs minor DNA errors. However, alcohol disrupts this repair process, leaving cells vulnerable to mutation and abnormal growth.

Dr. Giri adds that some people have genetic variations that make them break down alcohol more slowly. For these individuals, alcohol stays in the body longer, increasing the likelihood of DNA damage. Over years of repeated exposure, this can lead to uncontrolled cell growth and eventually cancer.

No Completely Safe Level of Alcohol For DNA Health

One of the most important points, Dr. Giri emphasizes, is that there is no entirely safe level of alcohol when it comes to DNA. The risk increases with both the frequency and quantity of drinking. Even occasional binge drinking can be harmful, meaning that how often you drink can be as important—or even more so—than how much you drink at one time.

This perspective shifts the discussion from asking “How much alcohol is too much?” to “How often am I exposing my cells to alcohol-induced damage?” Protecting DNA health requires regular monitoring and mindful drinking habits, even for those who feel healthy today.

Alcohol: Long-Term Health Implications

Alcohol-induced DNA damage is not just a short-term concern. Over time, the accumulation of mutations can significantly increase cancer risk and other serious diseases. Regular health check-ups, a balanced lifestyle, and moderation, or complete avoidance of alcohol are crucial steps for safeguarding your genetic health and overall well-being.

Dr. Amit Miglani highlights that “It’s not just about the organs you can feel being affected today; it’s about protecting your long-term health, especially your DNA, for the future.”

Dr. Arun Kumar Giri advises, “Understanding the cellular impact of alcohol helps people make informed choices about their drinking habits. Even small changes can significantly reduce the risk of long-term damage.”

New research suggests that menopause may be linked to a loss of grey matter in the brain, which could help explain why women face a higher risk of dementia compared to men. Scientists from the University of Cambridge analysed data from 124,780 women to explore how menopause affects the brain and whether hormone replacement therapy (HRT) might help protect against cognitive decline.

Menopause May Be Linked to Changes in Brain Structure

The researchers found that menopause was associated with reduced levels of grey matter, an essential part of the brain involved in thinking, memory, emotional processing and movement. The findings also noted that this stage of life is often accompanied by anxiety, depression and sleep problems. Previous research has already shown that menopause can affect cognitive abilities such as attention, language, learning and memory.

How Menopause And HRT Affect Thinking Speed

Published in the journal Psychological Medicine, the research divided participants into three groups: women who had not yet reached menopause, post-menopausal women who had never used HRT, and post-menopausal women who were taking HRT. Participants answered questions about sleep patterns, anxiety and depression, and some completed cognitive tests measuring memory and reaction time.

Around 11,000 women also underwent magnetic resonance imaging (MRI) scans, allowing scientists to closely examine brain structure. On average, menopause began at age 49 among the participants, and women who started HRT typically began treatment at around the same age.

Sleep, Fatigue and Mental Health Changes

The findings showed that post-menopausal women were more likely to struggle with insomnia, get less sleep overall and feel more fatigued. Interestingly, women using HRT reported the highest levels of tiredness across all three groups, even though they slept for a similar amount of time as those not taking HRT.

All post-menopausal women, regardless of whether they were using hormone therapy, reported greater fatigue compared to women who had not yet experienced menopause. Researchers also observed that this stage of life had an impact on cognitive function.

Dr Katharina Zuhlsdorff, from the psychology department at the University of Cambridge, explained: “As we age, our reaction times naturally slow down. This happens to both women and men and is part of normal ageing. You might still reach the right answer to a quiz question, but younger people tend to respond faster. Our findings suggest menopause speeds up this slowing process, while HRT seems to slow it down slightly.”

Brain Regions Linked to Memory and Emotion Affected

The study identified significant reductions in grey matter volume among post-menopausal women. These changes were seen in the hippocampus, which plays a key role in learning and memory, the entorhinal cortex, which supports memory formation and spatial awareness, and the anterior cingulate cortex, which helps regulate attention and emotions.

Menopause As A Period of Increased Vulnerability

Professor Barbara Sahakian, the senior author of the study from the department of psychiatry, said: “The brain areas where we observed these changes are the same regions commonly affected by Alzheimer’s disease. Menopause may make women more vulnerable later in life. While it does not explain everything, it could help clarify why dementia affects nearly twice as many women as men.”

Michelle Dyson, chief executive of the Alzheimer’s Society, noted that women account for roughly two-thirds of people living with Alzheimer’s disease in the UK. “Although we do not yet fully understand why women are more affected than men, hormones are thought to play a role,” she said.

“This large-scale study strengthens evidence that menopause has an impact on the brain, including physical changes such as reduced brain volume. However, without long-term follow-up to see whether participants later develop dementia, we cannot be certain that these menopause-related brain changes directly increase dementia risk.

“There are steps people can take today to lower their dementia risk, including regular exercise, avoiding smoking and cutting back on alcohol. Anyone concerned about themselves or a loved one can use the Alzheimer’s Society dementia symptoms checklist as a starting point before speaking to a GP.”

The research also found that women taking HRT were more likely to report mental health challenges. However, the analysis suggested these women already had poorer psychological wellbeing before starting hormone treatment.

Dr Christelle Langley, from the psychiatry department, said: “Menopause is something most women will experience, and it can be a major life change whether or not HRT is used. During this time, healthy habits such as staying active, exercising regularly and eating a balanced diet become especially important to help reduce some of its effects.”

Dr Louise Newson, a GP and women’s hormone specialist, added: “Many women notice changes in memory and concentration around menopause. This study suggests these symptoms may have a biological explanation rather than being brushed off as stress or ageing, highlighting menopause as a key window for protecting brain health and providing personalised care.”

More than 10 million adults, young people, and children in the UK are currently living with arthritis, according to a 2025 report by Arthritis UK. The NHS states that osteoarthritis is the most common form of the condition nationwide.

As per Cleveland Clinic, osteoarthritis develops gradually as joints become stiff and painful due to wear and tear. Symptoms can vary depending on the joint affected and the extent of damage, but pain, swelling, and reduced movement are common. While medication is often prescribed to manage symptoms, the NHS cautions that some commonly used treatments can carry health risks if taken long-term or without proper guidance.

One of the most frequently used pain relief options is non-steroidal anti-inflammatory drugs, commonly known as NSAIDs.

What Are NSAIDs?

NSAIDs, or non-steroidal anti-inflammatory drugs, are commonly prescribed by GPs to help relieve pain, swelling, and inflammation. They are available in several forms, including tablets, capsules, suppositories, creams, gels, and injections. Some NSAIDs can be purchased over the counter, while stronger versions require a prescription.

These medicines are often relied upon for day-to-day pain relief by people with osteoarthritis, particularly during flare-ups.

NHS Warning: Who Should Be Cautious When Using NSAIDs?

The NHS advises that NSAIDs may not be suitable for everyone. Extra caution is recommended for people with asthma, a history of stomach ulcers, angina, or those who have previously experienced a heart attack or stroke. The NHS also advises that individuals taking low-dose aspirin should always consult their GP before using NSAIDs.

Long-term or incorrect use can increase the risk of stomach bleeding, cardiovascular problems, and kidney issues, making it important to review pain management plans regularly.

Can Natural Compounds Like GOPO Support Joint Health?

Consultant Rheumatologist Dr Rod Hughes explains that natural compounds are increasingly being explored as supportive options for joint health.

“Natural compounds derived from plants have long been used in both traditional and modern medicine to support joint health. One such compound is GOPO, which is derived from rose hips (Rosa canina). Research indicates that GOPO can help relieve joint pain due to its anti-inflammatory properties,” he says.

“Rather than simply masking symptoms, GOPO works by helping to regulate the body’s inflammatory response, which is a key driver of joint stiffness, swelling, and discomfort. It offers a promising alternative to traditional painkillers, with fewer risks of side effects, making it a more sustainable option for managing joint discomfort.”

Lifestyle Changes Proven To Ease Osteoarthritis Pain

According to Dr Hughes, lifestyle measures form the foundation of osteoarthritis management.

“Lifestyle choices play a central role in relieving osteoarthritis pain and helping people stay active,” he explains. “Research shows that regular, gentle exercise supported by physiotherapy, such as walking, swimming, and yoga, can be highly effective.”

“These activities help keep joints mobile and strengthen the muscles and ligaments that support them, which reduces stiffness and eases pressure on painful joints. It is also important to balance activity with rest to avoid flare-ups caused by overuse.”

Why Weight Management Matters For Joint Health

Weight management is another key factor in controlling osteoarthritis symptoms. “Maintaining a healthy body weight is especially important,” says Dr Hughes. “Extra weight places additional load on joints, particularly the knees and hips, which can worsen pain and accelerate joint damage. Even modest weight loss has been shown to significantly reduce pain and improve mobility.”

How Diet Influences Inflammation And Joint Pain

Interestingly, diet can also play a role in managing inflammation linked to osteoarthritis. “Eating plenty of fresh fruit and vegetables, whole grains, nuts, and seeds, along with at least two portions of oily fish each week, provides antioxidants and omega-3 fatty acids that help reduce inflammation and protect against cell damage,” Dr Hughes explains.

“In my practice, I often recommend combining these dietary changes with natural supplements such as turmeric or GOPO to provide additional support for joint health.”

Reducing Reliance On Long-Term NSAIDs Safely

For patients hoping to reduce their dependence on NSAIDs, Dr Hughes stresses the importance of medical supervision.

“Any reduction in NSAIDs should be done gradually and under the guidance of a healthcare professional. This helps ensure pain remains well controlled while avoiding sudden flare-ups or withdrawal issues,” he says.

“By combining regular movement, physiotherapy, supportive nutrition, and appropriate natural supplements, many patients can take a more balanced approach to managing chronic joint pain. Over time, these strategies may allow people to rely less on medication while maintaining a good quality of life.”