The global challenge of HIV/AIDS remains one of the most pressing public health issues today. According to the latest data from UNAIDS, around 38.4 million people worldwide are living with HIV/AIDS, underlining the need for not only medical intervention but also comprehensive awareness, education, and social change. Despite the significant strides made in treatment and prevention, the confusion surrounding the relationship between HIV and AIDS still persists.

Young people have become influential advocates in the fight against HIV/AIDS. Research from UNICEF shows that youth-led initiatives can lower HIV transmission rates by as much as 45% in targeted communities. These young activists utilize digital platforms and peer-to-peer education to dispel myths, promote safe practices, and foster supportive environments for those affected by HIV/AIDS.

Dr Gowri Kulkarni, an expert in Internal Medicine, explains that while the terms HIV and AIDS are often used interchangeably, they are distinctly different. "HIV (Human Immunodeficiency Virus) is a virus that attacks the immune system, whereas AIDS (Acquired Immunodeficiency Syndrome) is a condition that occurs when HIV severely damages the immune system," she clarifies. To understand the implications of these differences, it's important to explore the fundamental distinctions between the two.

1. HIV is a Virus; AIDS is a Syndrome

HIV is the virus responsible for attacking the body’s immune system, specifically targeting CD4 cells, which are crucial for the body’s defense against infections. As HIV progresses, it destroys these cells, weakening the immune system over time. If left untreated, this continuous damage can lead to AIDS.

AIDS, on the other hand, is a syndrome, not a virus. Dr Kulkarni further elaborates that AIDS is a collection of symptoms and illnesses that emerge when the immune system is severely compromised due to prolonged HIV infection. It represents the most advanced stage of HIV, and is characterized by very low CD4 counts or the onset of opportunistic infections like tuberculosis, pneumonia, or certain cancers.

2. Not Everyone with HIV Develops AIDS

A key distinction to remember is that not everyone with HIV will progress to AIDS. Thanks to advancements in medicine, particularly antiretroviral therapy (ART), individuals living with HIV can manage the virus and maintain a healthy immune system for many years, or even decades, without ever developing AIDS. ART works by suppressing the virus to undetectable levels, effectively preventing the damage HIV would otherwise cause to the immune system.

Without treatment, however, HIV progresses through three stages:

- Acute HIV Infection: This stage occurs shortly after transmission and may include symptoms like fever, fatigue, and swollen lymph nodes.

- Chronic HIV Infection: Often asymptomatic or mildly symptomatic, the virus continues to damage the immune system but at a slower rate.

- AIDS: This is the final stage, marked by severe immune damage and the presence of infections that take advantage of the compromised immune defenses.

3. HIV is Transmissible; AIDS is Not

Another key distinction between HIV and AIDS is the way in which they are transmitted. HIV is highly contagious and can be transmitted through the exchange of bodily fluids such as blood, semen, vaginal fluids, and breast milk. It is primarily spread through unprotected sexual contact, sharing needles, or from mother to child during childbirth or breastfeeding.

AIDS, however, is not transmissible. It is not a disease that can be passed from one person to another. Rather, AIDS is the result of untreated, advanced HIV infection and is a direct consequence of the virus’s damage to the immune system.

4. Diagnosis Methods Differ

HIV and AIDS are diagnosed through different methods. HIV is diagnosed through blood tests or oral swabs that detect the presence of the virus or antibodies produced by the immune system in response to the virus. Early detection of HIV is crucial, as it allows for timely intervention and treatment, which can prevent the virus from progressing to AIDS.

AIDS, on the other hand, is diagnosed using more specific criteria. Dr Kulkarni notes that the diagnosis of AIDS is made when the individual’s CD4 cell count falls below 200 cells/mm³, or when opportunistic infections or certain cancers (such as Kaposi's sarcoma or lymphoma) are detected. Diagnosing AIDS involves a more thorough assessment of the individual’s immune function and overall health, as opposed to just the detection of HIV.

5. Treatment Goals Are Different

The treatment goals for HIV and AIDS differ significantly, although both involve antiretroviral therapy (ART). For HIV, the primary treatment goal is to suppress the virus to undetectable levels, thus maintaining a strong immune system and preventing further transmission of the virus. People living with HIV can often live long, healthy lives if they adhere to ART.

For individuals diagnosed with AIDS, the treatment plan becomes more complex. While ART remains an essential part of managing the virus, treatment for AIDS also focuses on addressing the opportunistic infections and secondary health complications associated with severe immune suppression. The goal of treatment for AIDS is not only to manage the HIV virus but also to improve the quality of life and extend survival by treating these secondary health issues.

Role of Community Engagement in Combatting HIV/AIDS

While the medical community has made great strides in managing HIV, the battle to curb its transmission is also a social and cultural issue. Dr Daman Ahuja, a public health expert, highlights that HIV/AIDS awareness and education are vital to reducing transmission rates and supporting those affected by the virus. "Young people, especially, have become key advocates in the fight against HIV/AIDS," says Dr Ahuja. "Research from UNICEF shows that youth-led initiatives can lower HIV transmission rates by as much as 45% in targeted communities."

Additionally, grassroots activism plays a significant role in raising awareness and addressing stigma. As the World Health Organization reports, community-based interventions have been proven to increase HIV testing rates and improve treatment adherence, which are crucial in the fight against the pandemic.

The ultimate goal of organizations like UNAIDS is to eliminate the HIV/AIDS pandemic by 2030. Achieving this requires global collaboration, from medical treatment advancements to public health strategies, education, and advocacy. Dr Kulkarni’s insight underscores the importance of early detection, treatment adherence, and community support in the fight against HIV/AIDS.

Dr Gowri Kulkarni is Head of Medical Operations at MediBuddy and Dr Daman Ahuja, a public health expert and has been associated with Red Ribbon Express Project of NACO between 2007-12.

A team of researchers in the US has developed a nanoparticle-based technique that could make laser surgeries for kidney stones faster, safer, and potentially reduce the chances of recurrence.

Engineers from the University of Chicago and doctors from Duke University added dark nanoparticles to a common saline solution used in kidney stone laser surgeries. Their method also promised less recurrence of disease.

The research focused on laser lithotripsy, a widely used surgical method in which lasers are used to break kidney or urinary tract stones into tiny fragments that can then be removed by suctioning or pass naturally.

How Nanofluid Boosts Lasery Surgery

Traditionally, surgeons use a small video-guided laser to fragment the stones. However, achieving effective fragmentation often requires higher laser power, which generates additional heat and causes damage to the surrounding tissues.

Thus the new method “is a way to better utilize the laser energy that is already being employed,” said Po-Chun Hsu, assistant professor at the University of Chicago Pritzker School of Molecular Engineering (UChicago PME).

Hsu noted that their nanoparticle-based “nanofluid” also has the potential to enhance the performance of lasers without increasing power levels. This will effectively fragment the stones and remove the dust particles.

The study, published in the journal Advanced Science, describes an innovative saline solution that enhances the performance of existing laser systems without requiring modifications to the equipment.

By adding dark nanoparticles that absorb laser wavelengths, the solution ensures that more of the laser energy is directed at the kidney stone rather than being reflected or dispersed.

“This improves the amount of laser energy that is transmitted to and absorbed by the stones,” said corresponding author Pei Zhong, a professor of engineering at Duke University.

“Nanofluid introduces a new dimension that can influence this complex physical process, independent of the stone composition or the laser being used,” Zhong said.

Kidney Stone Laser Surgery In 10 Minutes

Laboratory tests using artificial kidney stones showed that the nanofluid increased stone ablation efficiency by between 38 and 727 percent in spot treatments and by 26 to 75 percent in scanning treatments.

The researchers also tested the nanoparticle solution on living cells for up to 24 hours and found it to be non-toxic and safe.

In clinical settings, however, exposure would be much shorter. Laser lithotripsy is typically an outpatient procedure lasting about 30 minutes. The researchers believe that improved laser absorption could reduce the procedure time to around 10 minutes.

“If surgeries take too long, waste heat from the laser can accumulate and cause more harm than the stone removal itself,” Hsu said.

Kidney Stones: Symptoms And Prevention

Kidney stones are hard mineral or acid salt deposits formed in the kidneys. It occurs due to concentrated urine, and causes intense, radiating back/side pain, nausea, and blood in urine.

Common causes include

• dehydration,
• diet,
• obesity,
• family history
• metabolic issues

• staying well-hydrated
• reducing sodium levels
• eating fewer oxalate-rich foods
• consuming sufficient calcium-rich foods
• increasing citrus intake.

Former youth player of England, Amy Carr dies at the age of 35. England women's football team too paid tribute on her death. Carr was a former goalkeeper who played for England Under-17s and Under-19s. She was diagnosed with a brain tumor for a second time.

She was diagnosed in 2015 and raised more than £2,000 for charity by running the Dublin Marathon in 2024.

"We are heartbroken to hear that former England youth player Amy Carr has passed away aged 35," read a statement on the Lionesses' X account. "Amy, who was diagnosed with a second brain tumour in 2024, devoted her time to raising money for vital brain tumour research that could help others. She remains an inspiration to all."

Carr also played for Arsenal, Chelsea and Reading before she gained a football scholarship in the USA. Chelsea added on X: "We are saddened to learn of the passing of former Chelsea goalkeeper, Amy Carr. Our condolences are with Amy's friends and family at this time."

What Is Brain Tumor?

Before diving into the concept of a brain tumor, it is important to first understand what a tumor is. A tumor refers to an abnormal lump or mass that forms due to the uncontrolled growth of cells in the body.

tumors are broadly classified into two main categories:

• Benign
• Malignant

A benign tumor consists of normal cells that have grown excessively to form a lump. This overgrowth may result from something going wrong in the body, but the cells themselves are not cancerous. On the other hand, a malignant tumor is made up of abnormal cells that grow uncontrollably. These are cancerous cells, and their aggressive nature can lead to serious health issues.

A brain tumor is a condition in which abnormal cells develop within any part of the brain. Similar to tumors elsewhere in the body, brain tumors can also be benign (non-cancerous) or malignant (cancerous). The presence of a tumor in the brain can interfere with normal brain function, depending on its size, type, and location.

Our bodies possess a natural healing mechanism that is crucial for survival. This repair system is activated whenever there is damage from injury, radiation from the sun, or harmful chemicals in the environment. However, this process can occasionally go wrong. When it does, small clusters of cancerous cells may begin to form. In most cases, the immune system successfully detects and destroys these abnormal cells before they grow. But in rare instances, these cancerous cells evade immune detection and continue to grow, leading to the formation of tumors or cancers.

Such abnormal growths can occur anywhere in the body. When these growths are located in the brain or spinal cord, they are referred to as Central Nervous System (CNS) tumors.

India is home to 25 per cent of the world's annual count of cervical cancer fatalities. According to the World Health Organization GLOBOCAN report of 2022, India reports over 120,000 new cases with nearly 80,000 fatalities. This is the highest death-toll worldwide from cervical cancer each year.

In India, a new case is diagnosed every four minutes, and another woman dies approximately every seven minutes. Persistent infection with high-risk HPV strains, especially types 16 and 18, is the leading cause of cervical cancer. Meanwhile, studies show that even a single dose of the HPV vaccine can provide long-lasting, potentially lifelong protection.

To combat this, India launched a nationwide campaign to vaccinate young girl against the human papillomavirus (HPV). This is also the second most common cancer among women in the country. India kicked off the nationwide campaign on 28 February. Prime Minister Narendra Modi at Ajmer city in the western state of Rajasthan inaugurated this campaign. Vaccines were made available free-of-cost at government facilities to approximately 11.5 million girls aged 14 years across the country.

Currently, approximately one in every 50 girls born in India is expected to develop cervical cancer during her lifetime, and widespread vaccination is likely to reduce this risk significantly," said Partha Basu, Head, Early Detection, Prevention & Infections Branch at the International Agency for Research on Cancer.

What Is Cervical Cancer?

Cervical cancer develops in a women's cervix (uterus opening) due to abnormal cell growth, primarily caused by persistent HPV infection, a common infection that's passed through sexual contact.

When exposed to HPV, the body's immune system typically prevents the virus from causing damage however, in a small percentage of people, the virus can survive for years and pave the way for some cervical cells to become cancerous.

Treatment involves surgery, radiation, and chemotherapy, with early detection significantly improving outcomes, though it remains a major cancer in low-income countries Cervical cancer can also be prevented through vaccination and regular screening (Pap/HPV tests).

Symptoms Of Cervical Cancer

Cervical cancer has no symptoms in the early days and therefore, is hard to detect until it has spread. However, the early-stage symptoms include:

• Vaginal bleeding after sex
• Vaginal bleeding post-menopause
• Vaginal bleeding between periods or unusually heavy/long periods
• Watery vaginal discharge with a strong odor or containing blood
• Pelvic pain or pain during intercourse
• Advanced Cervical Cancer Symptoms (when cancer has spread beyond the cervix)
• Painful or difficult bowel movements or rectal bleeding
• Painful or difficult urination or blood in the urine
• Persistent dull backache
• Swelling of the legs
• Pain in the pelvis or lower abdomen