We often see celebrities go through weight loss transformations, with side-by-side comparisons of the before and after weight loss. But people often do not feel inspired or drawn to their stories as we all know that they have access to great personal trainers, high-end food products as well as better access to healthcare. But one story that was highlighted by Men’s Health in their ‘First Steps’ series can inspire many with the story of Simon Lafontant, who lost 150 pounds and went on to become a body builder.

Simon Lafontant, a 32-year-old from Calgary, had to deal with some serious health problems for a long time. These included low testosterone and Crohn's disease, which made his life difficult. But Simon decided he wanted to make a change. He got medical help for his low testosterone and then set a big goal for himself: to compete in a bodybuilding competition. He used social media to keep himself on track, and he ended up losing over 150 pounds and even winning the competition! His story is about how he went from struggling with his health to becoming a bodybuilding champion.

How A Disease Can Become A Turning Point

Simon talks about how he used to have bad habits and wasn't living a healthy lifestyle. This led to him feeling down, gaining weight, and losing motivation. Things got really serious in 2020 when his Crohn's disease caused him to be in the hospital for seven whole months. According to Mayo Clinic Crohn’s disease is a type of inflammatory bowel disease that is inflammation in your digestive tract which can be very painful and can cause people to need long term remission and time to heal the inflammation. Simon spoke about how he realized his poor lifestyle choices and being obese had made his symptoms worse!

While you may not wish to become a bodybuilder, there are many other aspects you can take away from the Simon’s story! Another trip to the doctors revealed that he had very low testosterone levels, which explained his lack of energy. This was a major turning point for him, as he finally understood some of the reasons behind his struggles.

What Role Does Testosterone Play?

One thing that made a huge difference in Simon’s weight loss journey was getting the TRT treatment for his low testosterone which had an almost immediate effect on him. He felt good, started enjoying things again, like going outside and working out. He also remembered how much he loved powerlifting and Strongman competitions, so this helped him get on to his path to bodybuilding and weight training!

Low testosterone affects both men and women, but in different ways. In women, it can cause low sex drive, tiredness, muscle weakness, trouble getting pregnant, irregular periods, vaginal dryness, mood changes like depression or anxiety, hair thinning, dry skin, and sleep problems. In men, low testosterone can lead to reduced sex drive, erectile dysfunction, hair loss, smaller testicles, hot flashes, and infertility. Other symptoms in men include feeling down, trouble concentrating or remembering things, and increased body fat. If you're experiencing any of these symptoms, it's a good idea to talk to a doctor.

Parkinson’s disease is characterized by slowness of daily activities, rigidity, and tremors with gait issues, commonly seen after the age of 45-50 years.

It is two times more common in men than women, though clinical features, response to the treatment, and prognosis are different in women as compared to men. From subtle early signs to how the condition develops over time, gender can shape the Parkinson’s journey in important ways.

Women usually experience Parkinson’s disease at a later age, but with faster progression of symptoms as compared to men. There is a need for more research in this space; however, we will try to shed light on these differences in Parkinson's trajectories in men and women based on available evidence.

Why Is Parkinson’s Less Common In Women?

Estrogen, a group of primary female sex hormones, is neuroprotective and protects dopaminergic neurons in women; women also have a higher baseline reserve of dopaminergic neurons. Hence, Parkinsonism is less common in women.

In the post-menopausal period, once this estrogen-related neuroprotective effect disappears, Parkinson’s symptoms progress rapidly. Motor symptoms emerge later in women with tremors, rigidity, and gait disturbances being more common and severe. Freezing of gait and postural instability with falls are more common in women.

Differences In Motor vs Non-Motor Symptoms

Non-motor symptoms like pain, fatigue, autonomic disturbances, sleep disorders, constipation, and mood disorders, including depression and anxiety, are more common and severe in women. Men with Parkinson’s disease have worse general cognitive abilities; however, women have worse visuospatial abilities.

Women with Parkinson’s receive less social support, lower quality care, attend medical appointments alone, and report more psychological stress. Women have a lower body mass index and higher bioavailability of levodopa, which makes them more susceptible to the side effects of levodopa, such as motor fluctuations and dyskinesia, which entail involuntary movements like fidgeting and writhing.

Why Personalized Treatment Matters

There is a clear need for personalized and tailored treatment. The different and distinctive clinical features in women, like later onset, higher tremors and rigidity, higher dyskinesia and motor fluctuations from drugs, and worse non-motor symptoms, require tailored, sex-specific treatment strategies rather than a “one-size-fits-all” approach.

Clinicians must give importance to the screening and management of non-motor symptoms in women, which are the main factors of their decreased quality of life. Women with this ailment go through longer delays in diagnosis and less access to specialists, highlighting a need for better healthcare access for women.

While HPV vaccines are most known for preventing cervical cancer, a top US doctor says they can also help curb the rising incidence of head and neck cancers.

According to Mikkael A. Sekeres, Chief of the Division of Hematology and Professor of Medicine at the Sylvester Comprehensive Cancer Center at the University of Miami, Human papillomavirus (HPV) — the same sexually transmitted virus that can infect the genital area and lead to cervical cancer — is now the greatest risk factor for head and neck cancer.

Writing in The Washington Post, Sekeres noted that HPV accounts for about 30 per cent of oropharyngeal cancer worldwide.

HPV is believed to be responsible for the recent rise in head and neck cancers, which include malignancies affecting the mouth and throat (oral cavity and pharynx), voice box (larynx), sinuses and nasal cavities, and salivary glands.

Sekeres said the US records about 60,000 new cases of head and neck cancers each year, while the global incidence is expected to rise by 30 per cent by 2030.

What Are The Risk Factors?

The expert noted that men develop oral cavity and pharynx cancers at approximately 2.5 times the rate of women.

Major risk factors include:

• Tobacco use, including smoking, secondhand smoke and smokeless tobacco
• Chewing areca nut, also known as betel quid
• Heavy alcohol consumption
• HPV infection

Also read: PM Modi Launches Nationwide Free HPV Vaccination Drive; A Landmark Step, Says WHO

The Centers for Disease Control and Prevention (CDC) estimates that the high-risk HPV subtypes most associated with head and neck cancers are detectable in the mouths of 4 per cent of adults aged 18 to 69.

While a pap test detects early-stage cervical cancer in women, no such test exists for penile, anal, or head and neck cancers in men, which can worsen their survival rate.

HPV Vaccination Best Prevention Strategy

Thus, Sekeres said: “The best way to prevent the most common types of HPV is through vaccination, with two doses of the vaccine recommended for children at age 11 or 12, or starting as early as 9 years and up to age 26 for those who missed it as a child".

He noted that although the vaccine is approved for use up to age 45, it is generally less beneficial after age 26 because many individuals may have already been exposed to HPV. However, doctors can help determine whether vaccination may still be beneficial for adults.

Earlier this year, the European Cancer Organization also urged broader HPV vaccination regardless of gender.

“HPV affects everyone, regardless of gender. It can lead to cancers of the cervix, mouth and throat, anus and penis. This is why universal protection is so important,” the organization said in a social media post.

Read More: Who Needs HPV Vaccine? Guide For Every Parent, Teen And Adult

HPV Vaccine Can Boost Cancer Risk

A 2026 study published in JAMA Oncology found that boys and men who received the HPV vaccine between the ages of 9 and 26 were nearly 50 per cent less likely to develop cancers of the head and neck, esophagus, anus, or penis.

The findings, based on data of more than 510,000 boys and men, highlight the importance of vaccinating all children and adolescents against HPV, said Taito Kitano, first author of the study and a researcher at Nara Prefecture General Medical Center in Japan.

“Children, adolescents, parents and health care workers should be more informed about the expected benefits of the HPV vaccine, not just cervical cancer,” Kitano said.

FIFA has launched a groundbreaking initiative aimed at advancing research and knowledge to boost health and performance of female athletes.

The FIFA Female Health and Performance Project comes ahead of the tenth edition of the FIFA Women's World Cup, which is scheduled to take place in Brazil next year.

The initiative aims to provide specialist, science-based educational resources tailored to the preparation and development of female athletes. It also seeks to close long-standing gaps in understanding the unique health and performance needs of female players, many of whom still lack access to the scientific data needed to support their development and optimize performance.

“FIFA’s aim is to optimize every female footballer’s health, well-being and performance, and to improve knowledge around women and girls in football at every level of the game,” said Sarai Bareman, FIFA’s Chief Women’s Football Officer.

“Collectively, we can do so much more to better support our growing number of female players and ensure they are trained, supported and understood according to their specific needs as women.”

Why Is The Initiative Significant?

Also read: Can Running Marathons Or Ultramarathons Raise Colon Cancer Risk?

A study analyzing 5,261 research articles published in sport and exercise science journals between 2014 and 2020 found that only 34% of study participants were female, while just 6% of sport science research focused exclusively on women.

Only 8% of elite female athletes have sufficient knowledge about how the menstrual cycle may affect training and performance.

Many training methodologies, workload models and performance benchmarks used in sport have historically been derived from male athlete data, requiring female athletes to adapt to systems that may not accurately reflect their physiological characteristics.

What Will The Project Achieve?

The initiative is designed to provide a comprehensive understanding of the female athlete, her individual needs, her environment and the tailored support required to optimize health and performance.

The educational modules cover universal topics in football and elite sport science, including sleep, recovery, strength and conditioning, all examined through the lens of the female athlete.

Female-specific topics such as physiology, pregnancy, postpartum health and menopause are also included.

Four separate learning levels — from “Introduction” to “Integrated” — provide tailored information for a wide range of audiences, from sports professionals to members of the general public.

Read More: Hepatologist Recommends 9 Most Effective Exercises For Better Liver Health

In addition to improving access to knowledge and education, the initiative aims to break taboos, normalize language, eliminate social stigma, encourage open communication and establish a supportive environment in which female athletes can thrive.

“We need to normalize conversations around female health and embrace this, using it to our advantage instead of ignoring it or being fearful of discussing it,” Bareman added. “It is not a weakness; it is a strength.”

Key areas covered by the project include:

• Female physiology
• Reproductive years
• Menstrual health tracking
• Pregnancy and postpartum health
• Fertility
• Menopause
• Pelvic health
• Nutrition
• Recovery
• Sleep
• Strength and conditioning
• Screening and profiling
• Injury and injury prevention

Who Will Benefit?

Available to all through FIFA’s Training Centre platform, the FIFA Female Health and Performance education modules are the result of collaboration with leading experts to generate, curate and apply the scientific evidence underpinning the program.

All 211 FIFA Member Associations will have access to specialised, peer-reviewed, science-based information through 13 tailor-made educational modules.