Stress is an unavoidable part of life, and while it often carries a negative connotation, it is actually a fundamental survival mechanism. When faced with a perceived threat, whether physical or emotional, the body instinctively reacts to protect itself. This automatic response is commonly known as the "fight, flight, or freeze" response. While it serves an essential function in dangerous situations, chronic activation of this response due to daily stressors can have significant consequences for mental and physical health.

The body’s response to stress is rooted in human evolution. When our ancestors encountered a predator, their nervous systems immediately prepared them to either confront the threat (fight), escape to safety (flight), or become still and unnoticed (freeze). While modern-day stressors may not include wild animals, our nervous system reacts similarly to job pressures, financial worries, or social conflicts.

According to the Cleveland Clinic, stress is the body's response to change, activating a physiological reaction that helps us adapt and protect ourselves. While short-term stress can be beneficial, prolonged exposure can lead to an overactive stress response, negatively impacting overall well-being.

The Three Stress Responses: Fight, Flight, and Freeze

1. Fight

The fight response prepares the body for direct action. When triggered, the nervous system releases adrenaline, increasing heart rate, blood pressure, and muscle tension. While this reaction once helped early humans fend off predators, today it manifests as irritability, frustration, or aggression.

For instance, the employee who has experienced too much workload may work extremely long hours just to succeed. In short term, the action may produce good results but mostly ends in burnout, anxiety, and physical illness, for example, tension headache or digestion problems.

2. Fight

The flight response triggers an intense need to remove oneself from a stressful situation. Just as our ancestors would flee from danger, modern individuals may avoid conflict, quit jobs impulsively, or detach from relationships when overwhelmed.

Flight mode is linked with restlessness and anxiety. Individuals may have a sense of needing to get up and go-pacing, changing environments constantly, or avoiding tasks that seem too overwhelming. Someone with a flight response might have the desire to change jobs constantly, relocate constantly, or become reclusive in order to avoid perceived dangers.

3. Freeze

The freeze response occurs when the nervous system perceives a threat as too overwhelming to fight or flee. Rather than taking action, individuals shut down, feeling numb, disconnected, or paralyzed by fear.

Unlike fight or flight, which involve heightened activation, freeze mode slows down physiological functions. A person experiencing freeze mode may feel physically unable to move, struggle to make decisions, or find themselves dissociating from their emotions. This can manifest in situations such as public speaking anxiety, where someone might "blank out" or feel stuck in the moment.

What Happens in the Body During A Stressful Event?

When faced with a stressor, the autonomic nervous system (ANS) activates, triggering physiological changes, including:

• Increased heart rate and breathing: The body pumps more oxygen to muscles and the brain in case action is needed.
• Muscle tension: The body prepares for movement, sometimes causing trembling or stiffness.
• Dilated pupils: Vision sharpens to detect potential threats.
• Dry mouth: Saliva production decreases as the body redirects energy to essential functions.
• Changes in skin tone: Blood flow is directed to vital organs, sometimes making the skin appear pale or flushed.

For those experiencing the freeze response, the body undergoes a different reaction, often reducing heart rate and causing physical immobility rather than heightened activation.

Strategies for Coping and Managing the Stress Response

While the stress response is necessary for survival, frequent activation due to daily stressors can take a toll on health. Recognizing your default response—whether fight, flight, or freeze—can help in developing effective coping mechanisms.

1. Moving to a Safe Space

If possible, changing your environment can help signal to your brain that the threat has passed. Stepping outside for fresh air, finding a quiet place, or distancing yourself from overwhelming stimuli can help regulate emotions.

2. Practicing Controlled Breathing

Deep, slow breathing can be used to counteract the stress response by engaging the parasympathetic nervous system, which promotes relaxation. Techniques such as diaphragmatic breathing or the 4-7-8 method (inhale for four seconds, hold for seven, exhale for eight) can be particularly effective in calming the body.

3. Engaging in Physical Activity

This helps release pent-up energy and aids in the endorphin cascade, natural boosters for our mood.

4. Seeking Social Support

Relieving oneself from stress can come in many ways, but sharing it with trusted friends, a family member, or a good therapist will sure give that psychological boost of hope. Social support is an especially effective way of cushioning people against the stressors that they are subjected to in chronic forms.

When to Seek Professional Help

While occasional stress is normal, chronic activation of the fight, flight, or freeze response can indicate underlying mental health concerns, such as anxiety disorders or post-traumatic stress disorder (PTSD). If stress is affecting daily life—leading to sleep disturbances, difficulty concentrating, or persistent feelings of fear—it may be time to consult a mental health professional.

Many working women who are pregnant tend to dismiss signs such as headaches, swelling, or vision changes, thinking that they are common during pregnancy. However, these issues can be caused by preeclampsia, a serious condition that requires timely attention, especially among busy working women.

What is preeclampsia?

Dr Prachi Sarin Sethi, Senior Consultant – Obstetrician, Gynaecologist & Laparoscopic Surgeon, Motherhood Hospitals, Gurgaon, said, "Pregnancy comes with many physical changes, and it is common for women to experience discomfort such as swelling, fatigue, or headaches. However, sometimes these symptoms may point to something more serious, namely preeclampsia, a pregnancy-related condition that can affect both the mother and baby. Working women tend to ignore the signs of this condition and struggle in silence. Preeclampsia is a condition that usually develops after the 20th week of pregnancy. It is mainly characterised by high blood pressure and can affect organs such as the liver and kidneys. If not managed in time, it can lead to serious complications for both mother and baby."

What are the causes of preeclampsia?

The exact cause of preeclampsia is not known. Certain factors increase the risk, including:

1. High blood pressure before pregnancy
2. First pregnancy
3. Multiple pregnancies (twins or more)
4. Obesity or diabetes
5. High stress levels and lack of rest

What are the symptoms of preeclampsia?

Many symptoms of preeclampsia are mistaken for normal pregnancy changes. These include:

1. Persistent headaches
2. Swelling in the face, hands, or feet
3. Blurred vision or light sensitivity
4. Sudden weight gain
5. Pain in the upper abdomen

Consequences of untreated preeclampsia

Working women may ignore these signs due to work pressure, long hours, or frequent travel, assuming they are just tired or stressed. If left untreated, preeclampsia can lead to serious complications such as:

1. Preterm delivery
2. Low birth weight of the baby
3. Organ damage in the mother
4. Seizures (a severe condition called eclampsia)

Early detection and proper care can help manage the condition and reduce risks.

This is why working women miss the signs

In today’s fast-paced lifestyle, many women continue working through pregnancy without slowing down. Long working hours, stress, irregular meals, and lack of rest tend to worsen symptoms. Many women delay check-ups or ignore warning signs, thinking they are minor issues.

What can women do?

Report any signs and symptoms, such as headaches and vision changes, to a doctor. De-stress by practising yoga and meditation. Monitor blood pressure regularly, avoid overexertion, and maintain a balanced diet consisting of fresh fruits, vegetables, whole grains, and pulses. Avoid junk, oily, and canned foods. It is also necessary to stay hydrated, attend regular health check-ups, and follow-up appointments.

Osteoarthritis (OA), long considered a “wear-and-tear” disease of old age, is increasingly being diagnosed in people as young as 30, according to new research.

The review by researchers at Indraprastha Apollo Hospitals suggests OA should be viewed as a heterogeneous syndrome rather than a single disease. The condition is driven by a combination of biological, biomechanical, metabolic, genetic, and molecular factors, but in youth obesity and poor lifestyle is surging the cases.

“Osteoarthritis is no longer confined to the elderly — we are now seeing patients as young as 30, often driven by obesity and sedentary lifestyles. This research makes clear that osteoarthritis is not a single disease but a spectrum of conditions,” said Dr. (Prof.) Raju Vaishya, Senior Consultant Orthopaedic and Joint Replacement Surgeon, Indraprastha Apollo Hospitals.

Noting that a one-size-fits-all approach may not help, the expert stressed the need for personalized treatment that recognizes the specific phenotype in each patient.

Also read: Can Running Marathons Or Ultramarathons Raise Colon Cancer Risk? Study Sparks Concern

Six Disease Subtypes Identified

The review, published in International Orthopaedics, identifies six disease subtypes, including inflammatory, metabolic, and pain-sensitization variants. Researchers recommend MRI-based tools and biomarker panels to guide treatment decisions.

Emerging technologies such as AI-assisted MRI scoring and PET-MRI with 18F-NaF may also enable earlier detection and better patient classification, although wider clinical adoption will require standardized protocols and large-scale validation studies.

Osteoarthritis Burden Rising Worldwide

More than 500 million people worldwide live with osteoarthritis, accounting for 7.6 per cent of the global population. According to Global Burden of Disease estimates, prevalence has increased by 132 per cent over the past 30 years and is projected to rise by another 60 per cent by 2050.

Women, people with obesity, and those with previous joint injuries are disproportionately affected.

What Is Osteoarthritis And Its Symptoms?

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Osteoarthritis occurs when the cartilage that cushions the ends of bones gradually wears down, causing joints to become stiff, painful, and less mobile.

The disease commonly affects the knees, hips, and small joints of the hands, although it can occur in almost any joint.

Common symptoms include:

• Joint pain
• Joint stiffness
• Difficulty moving affected joints
• Swelling
• Joint tenderness
• A grating or crackling sensation during movement
• Pain and stiffness after periods of inactivity
• Enlarged or knobbly joints
• Reduced range of movement
• Muscle weakness or muscle loss

How To Prevent Osteoarthritis

Experts say maintaining a healthy weight, staying physically active, avoiding prolonged sedentary behaviour, and preventing joint injuries can help lower the risk of osteoarthritis.

One of the biggest challenges in osteoarthritis treatment is the “care gap.” Many patients are too young or not yet severe enough for surgery but may spend years relying on medications that relieve symptoms without addressing the underlying mechanics of joint stress.

Research suggest gait retraining — adjusting the way a person walks — could help bridge this gap. Unlike medication or surgery, gait retraining is non-invasive and may offer a sustainable long-term solution.

Currently, gait retraining often requires specialized tools such as motion-capture systems and pressure-sensitive treadmills. However, newer approaches, including smartphone-based video analysis and sensor-equipped “smart shoes,” are being developed to make the technique more accessible.

Experts caution against making major changes to walking patterns without professional guidance, as improper adjustments may place additional strain on other parts of the body.

After the COVID-19 pandemic, a large number of young adults returned to social life with unhealthy coping habits such as smoking, vaping, alcohol consumption, late-night eating, and excessive spicy or junk food intake. These are now causing a worrisome surge in cases of mouth cancer in people below 40. Youngsters fail to pay attention to the early warning signs, such as unhealed mouth ulcers, a burning sensation, white patches, difficulty swallowing, or persistent mouth pain, leading to delayed diagnosis. Hence, it is the need of the hour to seek timely treatment, which can save lives.

What is mouth cancer?

Mouth cancer, also known as oral cancer, refers to the abnormal growth of malignant cells in the gums, lips, tongue, or the inner lining of the cheeks and floor of the mouth. Early detection of this disease can help improve survival rates. The symptoms of mouth cancer are:

1. Sore or blister inside the mouth that lasts for two to three weeks
2. Bleeding
3. Numbness
4. Lump or swelling or thickening of the mouth, lip or neck
5. Persistent pain in the mouth
6. Persistent white or red patches in the mouth
7. Difficulty in swallowing or speaking

What are the risk factors for mouth cancer?

According to doctors, mouth cancer can happen to anyone. But there are some risk factors that can make you more prone to developing the tumour:

1. Smoking
2. Tobacco use or chewing tobacco
3. Using betel nut or paan
4. HPV
5. Frequent or heavy alcohol use
6. Excessive exposure to the sun
7. Poor oral hygiene

For timely detection, it is important to go for regular check-ups. If any of the symptoms appear, a biopsy can help with cancer detection.

Why are mouth cancer cases rising among people in their 40s?

Dr Prathamesh Pai, Senior Consultant Head and Neck Surgical Oncologist, Gleneagles Hospital, Parel, Mumbai, said, “There is a spike in cases of mouth cancer among younger individuals aged 25–40. The causes can be smoking, vaping, alcohol intake, poor dietary habits, and spicy junk food. Many youngsters believe mouth ulcers are common and harmless, but any ulcer that does not heal within two weeks should never be ignored. Early symptoms may include mouth pain, white or red patches, bleeding, difficulty chewing, bad breath, or swelling inside the mouth. Also, there is a lack of dental hygiene, and almost no one visits the dentist on a regular basis. In a week, three out of five patients visiting our clinic come with signs of unhealed mouth ulcers, white and red patches, difficulty opening the mouth, or altered speech and swallowing, and are often diagnosed with mouth cancer.”

Tobacco in any form, including vaping, can damage the body from the oral cavity to the lungs, as well as the heart, urinary bladder, and brain. Combined with alcohol, the incidence of cancer rises threefold. Maintaining good oral hygiene, avoiding tobacco and alcohol, reducing spicy processed food intake, and undergoing regular dental or oral check-ups are key to preventing mouth cancer, and early detection can lead to a cure.