Stress is an unavoidable part of life, and while it often carries a negative connotation, it is actually a fundamental survival mechanism. When faced with a perceived threat, whether physical or emotional, the body instinctively reacts to protect itself. This automatic response is commonly known as the "fight, flight, or freeze" response. While it serves an essential function in dangerous situations, chronic activation of this response due to daily stressors can have significant consequences for mental and physical health.

The body’s response to stress is rooted in human evolution. When our ancestors encountered a predator, their nervous systems immediately prepared them to either confront the threat (fight), escape to safety (flight), or become still and unnoticed (freeze). While modern-day stressors may not include wild animals, our nervous system reacts similarly to job pressures, financial worries, or social conflicts.

According to the Cleveland Clinic, stress is the body's response to change, activating a physiological reaction that helps us adapt and protect ourselves. While short-term stress can be beneficial, prolonged exposure can lead to an overactive stress response, negatively impacting overall well-being.

The Three Stress Responses: Fight, Flight, and Freeze

1. Fight

The fight response prepares the body for direct action. When triggered, the nervous system releases adrenaline, increasing heart rate, blood pressure, and muscle tension. While this reaction once helped early humans fend off predators, today it manifests as irritability, frustration, or aggression.

For instance, the employee who has experienced too much workload may work extremely long hours just to succeed. In short term, the action may produce good results but mostly ends in burnout, anxiety, and physical illness, for example, tension headache or digestion problems.

2. Fight

The flight response triggers an intense need to remove oneself from a stressful situation. Just as our ancestors would flee from danger, modern individuals may avoid conflict, quit jobs impulsively, or detach from relationships when overwhelmed.

Flight mode is linked with restlessness and anxiety. Individuals may have a sense of needing to get up and go-pacing, changing environments constantly, or avoiding tasks that seem too overwhelming. Someone with a flight response might have the desire to change jobs constantly, relocate constantly, or become reclusive in order to avoid perceived dangers.

3. Freeze

The freeze response occurs when the nervous system perceives a threat as too overwhelming to fight or flee. Rather than taking action, individuals shut down, feeling numb, disconnected, or paralyzed by fear.

Unlike fight or flight, which involve heightened activation, freeze mode slows down physiological functions. A person experiencing freeze mode may feel physically unable to move, struggle to make decisions, or find themselves dissociating from their emotions. This can manifest in situations such as public speaking anxiety, where someone might "blank out" or feel stuck in the moment.

What Happens in the Body During A Stressful Event?

When faced with a stressor, the autonomic nervous system (ANS) activates, triggering physiological changes, including:

• Increased heart rate and breathing: The body pumps more oxygen to muscles and the brain in case action is needed.
• Muscle tension: The body prepares for movement, sometimes causing trembling or stiffness.
• Dilated pupils: Vision sharpens to detect potential threats.
• Dry mouth: Saliva production decreases as the body redirects energy to essential functions.
• Changes in skin tone: Blood flow is directed to vital organs, sometimes making the skin appear pale or flushed.

For those experiencing the freeze response, the body undergoes a different reaction, often reducing heart rate and causing physical immobility rather than heightened activation.

Strategies for Coping and Managing the Stress Response

While the stress response is necessary for survival, frequent activation due to daily stressors can take a toll on health. Recognizing your default response—whether fight, flight, or freeze—can help in developing effective coping mechanisms.

1. Moving to a Safe Space

If possible, changing your environment can help signal to your brain that the threat has passed. Stepping outside for fresh air, finding a quiet place, or distancing yourself from overwhelming stimuli can help regulate emotions.

2. Practicing Controlled Breathing

Deep, slow breathing can be used to counteract the stress response by engaging the parasympathetic nervous system, which promotes relaxation. Techniques such as diaphragmatic breathing or the 4-7-8 method (inhale for four seconds, hold for seven, exhale for eight) can be particularly effective in calming the body.

3. Engaging in Physical Activity

This helps release pent-up energy and aids in the endorphin cascade, natural boosters for our mood.

4. Seeking Social Support

Relieving oneself from stress can come in many ways, but sharing it with trusted friends, a family member, or a good therapist will sure give that psychological boost of hope. Social support is an especially effective way of cushioning people against the stressors that they are subjected to in chronic forms.

When to Seek Professional Help

While occasional stress is normal, chronic activation of the fight, flight, or freeze response can indicate underlying mental health concerns, such as anxiety disorders or post-traumatic stress disorder (PTSD). If stress is affecting daily life—leading to sleep disturbances, difficulty concentrating, or persistent feelings of fear—it may be time to consult a mental health professional.

Back pain is generally considered a problem seen in old age, but of late, we are increasingly seeing younger adults suffering from back pain. Prolonged sitting hours, inadequate physical activity, smoking, and an unhealthy lifestyle have made back pain a common complaint even in people under 30 years of age.

What is a slipped disc?

In an interview with Health and Me, Dr Pramod Sudarshan, Spine Surgeon (ortho), Apollo Hospitals, Bangalore, said, “Most commonly, we attribute this pain to a slipped disc or other disc-related conditions. However, they are just one among many reasons causing back pain. A thorough understanding of the other conditions that can lead to back pain, and knowing the ‘red flags’ to help identify them, will assist in seeking early treatment and preventing further complications.”

Muscle strain is considered to be one of the most common reasons for developing back pain in younger individuals. Daily activities like travelling for long hours, lifting heavy weights without proper technique, and carrying heavy backpacks can lead to muscle strain. Often, the pain due to muscle strain comes down with the help of medications such as muscle relaxants and rest.

Poor posture and back pain

Working professionals and students spend many hours a day studying, gaming, and working on computers without maintaining proper posture, leading to excess strain on the back muscles and, in turn, prolonged back pain. Having a properly ergonomically designed workstation/study table setup can prevent back discomfort and stiffness.

What are the causes of back pain?

Lack of physical activity and associated conditions such as obesity weaken our core muscles, which are considered the main pillars supporting our spine. Weakened core muscles will not be able to perform the functions expected of them, leading to back pain. Regular exercise, weight management, a healthy diet, and guided weight training will help strengthen our core muscles and reduce the risk of back pain.

Other than muscles, the spine also contains small joints known as facet joints, irritation or inflammation of which can lead to back pain. A structure known as the pars interarticularis acts as a clamp in the spine, holding two adjacent vertebral bodies, and any defect, such as a congenital defect or fracture due to repetitive microtrauma, as seen in gymnasts, can lead to the slipping of one bone over the other, causing back pain.

Though mechanical back pain is most common, there are other conditions such as inflammatory arthropathy, tumours, and infections. Conditions such as ankylosing spondylitis, rheumatoid arthritis, and hyperuricemia/gout are some examples of inflammatory conditions in which an individual experiences early morning back pain associated with stiffness and may also present with pain in other joints.

Can tuberculosis lead to back pain?

Tuberculosis affecting the spine is considered the most common infection of the spine. Severe back pain, weight loss, loss of appetite, fever, and night sweats are some of the common symptoms. Other bacterial and fungal infections are also seen affecting the spine, most commonly in immunocompromised individuals.

Tumours, though rare in young individuals, warrant further investigation when symptoms such as severe weight loss, night pain, and prolonged back pain are present to rule out the possibility of tumours.

Other conditions such as scoliosis (congenital/adolescent idiopathic scoliosis), which is a three-dimensional deformity of the spine, can cause back pain. It requires further assessment in the form of radiological investigations to assess the degree of deformity and to plan any surgical intervention, if required, based on the severity of the curve.

What are the symptoms?

Identifying some of the red-flag signs, such as weakness in the legs, numbness around the groin, bladder or bowel dysfunction, fever, unexplained significant weight loss, or severe pain following major trauma, is essential. These symptoms may indicate serious underlying pathology requiring medical care.

Fortunately, back pain in young people is largely preventable. Basic lifestyle modifications such as regular exercise, maintaining proper posture, avoiding prolonged sitting, maintaining a healthy body weight, undertaking monitored weight-training programmes, following a healthy diet, and getting adequate sleep will help prevent as well as overcome existing back problems. Invest in your spinal health at the earliest opportunity to reap the benefits in the second half of life.

Researchers from the University of Oxford and pharmaceutical firm Moderna have developed a vaccine that may prevent bowel and ovarian cancer. The first trial is to be this summer, and it will try to see if the vaccine can train the immune system to recognize and eliminate pre-cancerous cells in people with Lynch syndrome before cancer develops.

In the United Kingdom, one in 300 people has Lynch syndrome, an inherited health condition that massively increases the chance of contracting cancers like bowel and ovarian cancer.

What Is Colorectal Cancer?

Colorectal cancer is the umbrella term for both colon and rectal cancer. As the name also suggests, colon cancers happen only in the colon, but if it is left untreated, it can spread to different organs in your body. Colorectal cancer begins inside the rectal tissues or the colon walls. It presents itself in the earliest stages as small masses, known as polyps. If a polyp becomes cancerous, it can spread cancer from the inner part of the colon to the lymph nodes or bloodstream. If this happens, cancer can then quickly move throughout the system.

Early Symptoms Of Colorectal Cancer

• Persistent changes in bowel habits, especially if they last more than a few days, must be taken seriously. Narrow or ribbon-shaped stools may indicate a tumor partially blocking the colon.
• Blood in the stool is one of the most common and concerning signs. While it might be due to hemorrhoids or fissures, it’s important not to assume. A proper evaluation is critical.
• Unexplained weight loss: Especially when unintentional.
• Abdominal cramps or bloating: Misinterpreted as common digestive issues.

What Is Ovarian Cancer?

Ovarian cancer is one of the deadliest gynecological cancers and is often referred to as the “silent killer” because its early symptoms are vague and easily mistaken for common digestive or urinary issues.

It develops when abnormal cells in the ovaries grow uncontrollably and may spread to other parts of the body. Survival rates are significantly higher when detected early—around 93 per cent of women diagnosed at stage one survive at least five years, compared to just 13 per cent at stage four, according to the American Cancer Society.

Unfortunately, many cases are diagnosed at advanced stages, when treatment options are limited, and outcomes are poorer.

• Early Symptoms Often Overlooked

“Ovarian cancer is commonly called a ‘silent disease’ because its early signs are vague and often resemble routine gastric issues,” Dr. Tejinder Kataria, Chairperson – Radiation Oncology, Medanta Hospital, Gurugram, told HealthandMe.

Common symptoms include:

• Persistent bloating
• Feeling full quickly or reduced appetite
• Pelvic or abdominal discomfort
• Unexplained constipation or diarrhea
• Ongoing indigestion
• Excessive gas
• Abdominal heaviness

Dr. Parminder Kaur, Consultant Gynaecologic Oncologist at CK Birla Hospital, Delhi, told HealthandMe that the key concern is when symptoms become frequent, persistent, and unusual for an individual’s normal health pattern.

Every year, millions of people undergo routine health check-ups that include a lipid profile. Yet for many, the numbers on the report—Low-Density Lipoprotein (LDL), High-Density Lipoprotein (HDL), triglycerides, and increasingly ApoB—remain confusing.

Most people know that cholesterol is linked to heart disease and that "good" cholesterol can be beneficial, while high levels of "bad" cholesterol may increase cardiovascular risk. However, understanding what the different lipid profile numbers mean—and which ones matter most—can make a significant difference to long-term heart health.

Taking to the social media platform X, noted neurologist Dr. Sudhir Kumar said, "This is mainly meant for people who have NOT suffered a heart attack or stroke and are NOT already taking statins."

How Often Should You Get Tested?

Dr. Sudhir, Senior Consultant Neurologist at the Institute of Neurosciences, Apollo Hospitals, Hyderabad, shared that for most healthy adults, a lipid profile every two to three years is generally sufficient.

However, more frequent testing may be necessary for people with:

• Diabetes
• High blood pressure
• Obesity
• A history of smoking
• A family history of premature heart disease
• Previously abnormal cholesterol levels

LDL: Why This Cholesterol Matters

Also read: AHA’s New Dyslipidemia Guidelines Stress Early Screening, Lifestyle Management

LDL cholesterol, commonly known as LDL-C, is often referred to as "bad cholesterol." The expert explained its key role in the development of heart disease.

"Excess LDL can enter artery walls and contribute to plaque formation. Over time, these plaques may narrow blood vessels or rupture, increasing the risk of heart attacks and strokes," Dr. Sudhir said.

For most healthy adults, LDL levels below 100 mg/dL are considered desirable. Levels above this range gradually increase cardiovascular risk, particularly when elevated over many years.

The lower the LDL, the lower the long-term risk of heart attack and stroke. On the other hand, persistently high LDL can increase the lifetime risk of:

• Heart attack
• Stroke
• Peripheral artery disease

Triglycerides: A Marker Of Metabolic Health

Triglycerides are another type of fat found in the bloodstream. High levels of triglycerides are often a marker of poor metabolic health, Dr. Sudhir said.

He added that high triglycerides can indicate:

• Insulin resistance
• Obesity
• Prediabetes
• Diabetes
• Physical inactivity
• Excessive alcohol consumption
• Diets rich in refined carbohydrates and sugary beverages

What About HDL?

High-density lipoprotein, or HDL, has long been known as "good cholesterol." Traditionally, higher HDL levels have been associated with lower cardiovascular risk.

However, recent research has challenged the idea that simply raising HDL improves heart health. Several medications designed to increase HDL levels failed to reduce heart attack risk, prompting a shift in focus toward lowering harmful cholesterol particles rather than boosting HDL alone.

As a result, the expert cautioned against judging cardiovascular health based solely on HDL levels.

ApoB: The Emerging Risk Marker

Read More: Cardiovascular Diseases Lead As India’s Top Killer: US Cardiologist Points Out Risk Factors

One of the most important developments in cardiovascular prevention is the growing recognition of Apolipoprotein B, or ApoB. Dr. Sudhir stated that ApoB is a protein found on potentially harmful cholesterol-carrying particles such as LDL and VLDL (Very Low-Density Lipoprotein, a type of "bad" cholesterol).

"Think of ApoB as a count of the particles capable of entering artery walls and causing plaque. One ApoB is equal to one potentially harmful particle," the expert said.

ApoB is important because two people may have the same LDL level, but only one may have many more cholesterol-carrying particles. That person will often have a higher ApoB level and potentially higher cardiovascular risk. ApoB often provides a more accurate assessment of risk than LDL alone, the neurologist explained.

He suggested that ApoB testing should be considered by people with diabetes, prediabetes, metabolic syndrome, obesity, elevated triglycerides, or a strong family history of heart disease.

How To Improve Lipid Profile Naturally?

• Exercising regularly
• Maintaining a healthy body weight
• Avoiding smoking
• Limiting sugary drinks
• Reducing ultra-processed foods
• Eating more vegetables, fruits, and legumes
• Choosing healthier sources of fat
• Prioritizing good sleep.