Stress is an unavoidable part of life, and while it often carries a negative connotation, it is actually a fundamental survival mechanism. When faced with a perceived threat, whether physical or emotional, the body instinctively reacts to protect itself. This automatic response is commonly known as the "fight, flight, or freeze" response. While it serves an essential function in dangerous situations, chronic activation of this response due to daily stressors can have significant consequences for mental and physical health.

The body’s response to stress is rooted in human evolution. When our ancestors encountered a predator, their nervous systems immediately prepared them to either confront the threat (fight), escape to safety (flight), or become still and unnoticed (freeze). While modern-day stressors may not include wild animals, our nervous system reacts similarly to job pressures, financial worries, or social conflicts.

According to the Cleveland Clinic, stress is the body's response to change, activating a physiological reaction that helps us adapt and protect ourselves. While short-term stress can be beneficial, prolonged exposure can lead to an overactive stress response, negatively impacting overall well-being.

The Three Stress Responses: Fight, Flight, and Freeze

1. Fight

The fight response prepares the body for direct action. When triggered, the nervous system releases adrenaline, increasing heart rate, blood pressure, and muscle tension. While this reaction once helped early humans fend off predators, today it manifests as irritability, frustration, or aggression.

For instance, the employee who has experienced too much workload may work extremely long hours just to succeed. In short term, the action may produce good results but mostly ends in burnout, anxiety, and physical illness, for example, tension headache or digestion problems.

2. Fight

The flight response triggers an intense need to remove oneself from a stressful situation. Just as our ancestors would flee from danger, modern individuals may avoid conflict, quit jobs impulsively, or detach from relationships when overwhelmed.

Flight mode is linked with restlessness and anxiety. Individuals may have a sense of needing to get up and go-pacing, changing environments constantly, or avoiding tasks that seem too overwhelming. Someone with a flight response might have the desire to change jobs constantly, relocate constantly, or become reclusive in order to avoid perceived dangers.

3. Freeze

The freeze response occurs when the nervous system perceives a threat as too overwhelming to fight or flee. Rather than taking action, individuals shut down, feeling numb, disconnected, or paralyzed by fear.

Unlike fight or flight, which involve heightened activation, freeze mode slows down physiological functions. A person experiencing freeze mode may feel physically unable to move, struggle to make decisions, or find themselves dissociating from their emotions. This can manifest in situations such as public speaking anxiety, where someone might "blank out" or feel stuck in the moment.

What Happens in the Body During A Stressful Event?

When faced with a stressor, the autonomic nervous system (ANS) activates, triggering physiological changes, including:

• Increased heart rate and breathing: The body pumps more oxygen to muscles and the brain in case action is needed.
• Muscle tension: The body prepares for movement, sometimes causing trembling or stiffness.
• Dilated pupils: Vision sharpens to detect potential threats.
• Dry mouth: Saliva production decreases as the body redirects energy to essential functions.
• Changes in skin tone: Blood flow is directed to vital organs, sometimes making the skin appear pale or flushed.

For those experiencing the freeze response, the body undergoes a different reaction, often reducing heart rate and causing physical immobility rather than heightened activation.

Strategies for Coping and Managing the Stress Response

While the stress response is necessary for survival, frequent activation due to daily stressors can take a toll on health. Recognizing your default response—whether fight, flight, or freeze—can help in developing effective coping mechanisms.

1. Moving to a Safe Space

If possible, changing your environment can help signal to your brain that the threat has passed. Stepping outside for fresh air, finding a quiet place, or distancing yourself from overwhelming stimuli can help regulate emotions.

2. Practicing Controlled Breathing

Deep, slow breathing can be used to counteract the stress response by engaging the parasympathetic nervous system, which promotes relaxation. Techniques such as diaphragmatic breathing or the 4-7-8 method (inhale for four seconds, hold for seven, exhale for eight) can be particularly effective in calming the body.

3. Engaging in Physical Activity

This helps release pent-up energy and aids in the endorphin cascade, natural boosters for our mood.

4. Seeking Social Support

Relieving oneself from stress can come in many ways, but sharing it with trusted friends, a family member, or a good therapist will sure give that psychological boost of hope. Social support is an especially effective way of cushioning people against the stressors that they are subjected to in chronic forms.

When to Seek Professional Help

While occasional stress is normal, chronic activation of the fight, flight, or freeze response can indicate underlying mental health concerns, such as anxiety disorders or post-traumatic stress disorder (PTSD). If stress is affecting daily life—leading to sleep disturbances, difficulty concentrating, or persistent feelings of fear—it may be time to consult a mental health professional.

Heart clips—also referred to as heart valve clips—are part of a minimally invasive medical procedure known as Transcatheter Edge-to-Edge Repair (TEER). Designed to repair leaking heart valves without open-heart surgery, this advanced treatment restores proper blood flow, relieves debilitating symptoms, and helps patients return to their daily lives.

Understanding Valve Leakage and Symptoms

The heart's valves rely on thin flaps of tissue called leaflets to regulate blood flow.

• The mitral valve (located on the left side of the heart) typically has two leaflets.

• The tricuspid valve (located on the right side of the heart) usually consists of three leaflets.

When a valve is leaking, the leaflets fail to close completely, leaving a gap. Blood leaks backward through this opening toward the lungs, increasing lung pressure and directly causing chronic breathlessness and fatigue.

Also read: 100% Blockage At 18, 25% Patients Under 40: On World Heart Day, Cardiologists Reveal An Alarming Heart Attack Pattern

How the Clip Repair Procedure Works

During a Transcatheter Edge-to-Edge Repair, cardiologists repair the valve using a tiny clip delivered through the vascular system:

1. Catheter Access: Guided by continuous echo imaging, doctors insert a catheter into a blood vessel in the groin and navigate it directly to the heart.
2. Targeting the Valve: The catheter goes to the left side of the heart for a mitral valve repair or to the right side for a tricuspid valve repair.
3. Identifying the Leak: Imaging pinpoints the exact spot where the leaflets fail to seal.
4. Deploying the Clip: The doctor positions and deploys the clip across the leaking gap, grasping the two opposing leaflets and pulling them closer together.
5. Evaluating the Seal: Before releasing the clip completely, doctors perform an echocardiogram to confirm that the clip is strongly anchored, that the backward leak is fixed, and that the risk of clip detachment (embolization) is negligible.

Immediate Relief and Long-Term Healing

Once the clip brings the leaflets together, backward leakage stops immediately, allowing the entire volume of blood to pump forward as intended.

• 24-Hour Recovery: Pressure inside the lungs drops rapidly once the leak is sealed. Many patients notice a dramatic improvement in their breathing within 24 hours of the procedure.

• 3 to 6 Month Integration: Over a period of three to six months, surrounding heart tissue naturally grows over the clip (endothelialization), permanently integrating it into the heart structure.

Smooth Hospital Stay and Recovery

Because the procedure is catheter-based rather than open-chest, patient recovery is remarkably swift:

• In-Room Extubation: Patients are taken off the ventilator right on the procedure table.

• Minimal Closure Site: The groin entry point is closed cleanly using specialized sutures (such as ProGlide or a figure-of-eight suture).

• Quick Discharge: Patients typically spend just one day in the Intensive Care Unit (ICU) before moving to a standard room, after which they can return home and resume normal daily activities.

Frequent cannabis use may worsen epilepsy-related symptoms, new research. It discovered that raised that people with drug-resistant epilepsy who used cannabis often had more frequent convulsive seizures and sought advanced epilepsy care much sooner than non-users.

Published in Epilepsia, the study analysed health records of 64 adults with drug-resistant epilepsy. It found that frequent cannabis users reached an intensive epilepsy monitoring stage an average of five years after their first seizure, compared to 18 years reported among non-users.

The difference of 13 years is attention-worthy but it must be noted that the study shows an association, not proof that cannabis worsens epilepsy.

Seizures Doubled In Cannabis Users With Epilepsy

Researchers compared 22 people who used cannabis at least 20 days a month to 42 people who did not.

The frequent users reported to have a heavier burden of seizure, one of the symptoms of epilepsy. They had more than twice as many convulsive seizures per year than non-users.

About 91% of frequent cannabis users experienced convulsive seizures, compared to roughly half of the non-users.

Seizures involve stiffening and jerking of the body and loss of consciousness. They constitute medical emergency as they are associated with sudden death in epilepsy.

Also read: Does Cannabis Really Help You Sleep? Experts Say It Is Complicated

What Does Drug-Resistant Epilepsy Mean?

Epilepsy is considered drug-resistant when seizures continue despite appropriate treatment with two antiseizure medications.

People with drug-resistant epilepsy may need to visit specialised epilepsy centres, where doctors can monitor them and recommend changes in medication, surgery, or other treatment options. In this study, frequent cannabis users reached this stage much earlier.

They were also discharged from hospital after taking an average of 3.05 antiseizure medications, compared with 2.21 among non-users.

Also read: Why Can’t Millennials Sleep? The Crisis Keeping An Entire Generation Up At Night

Cannabis & Epilepsy

This was a retrospective study based on health records of a small sample size. There may be other differences between people who used cannabis often and those who did not that could affect the severity of the seizures.

However, researchers were able to establish the timing of cannabis use for 15 of the 22 users. All 15 had started using cannabis before their first seizure, making it less likely that they had simply begun using cannabis to cope with an already existing seizure disorder.

The researchers say larger studies can determine whether cannabis contributes to worsening seizures.

The association between cannabis and seizures is complicated as CBD (cannabidiol) is reported to have beneficial effect on severe epilepsy.

To understand the seeming contradiction, we must understand the distinction between cannabis and purified cannabidiol (CBD).

A purified form of CBD is an approved treatment for certain severe forms of epilepsy. CBD is different from THC, the psychoactive element responsible for the “high” associated with cannabis. Recreational cannabis products may contain high concentrations of THC.

According to the researchers, animal studies suggest CBD can suppress seizures, while THC may have the opposite effect.

Hence, evidence that a specific CBD-based medicine can help certain epilepsy syndromes cannot be used to conclude that recreational cannabis is an epilepsy treatment.

Researchers suggest that THC acts on receptors concentrated in brain regions involved in seizures, raising the possibility that cannabis could influence how brain circuits fire. But this is a hypothesis that needs further investigation.

A stroke changes the life of a person in an instant, making everyday activities like walking, talking, or even holding a cup difficult. But strokes do not always mean these challenges are permanent. Many people recover lost abilities and enhance their lives with timely treatment, proper rehabilitation and continued support.

A stroke occurs when blood stops flowing to the brain or a blood vessel in the brain bursts, cutting off oxygen to brain cells. It can cause weakness or paralysis, speech problems, poor balance, or memory issues, or trouble swallowing, depending on the part of the brain that is affected.

Tips to Support Recovery from Stroke

• Begin rehabilitation immediately after a stroke
• Attend Physiotherapy and speech Therapy sessions regularly
• Take prescribed medications as directed.
• Keep blood pressure, diabetes and cholesterol under control.
• Have a healthy and nutritious diet to restore energy.
• Stay physically active
• Seeking emotional and psychological support

Also read: 100% Blockage At 18, 25% Patients Under 40: On World Heart Day, Cardiologists Reveal An Alarming Heart Attack Pattern

The Treatment Journey:

Timely Medical Care Makes a Big Difference

Patients who reach the hospital within a certain time may be eligible for clot-busting medications or clot removal procedures. These procedures restore blood flow, reduce brain damage and increase the likelihood of faster recovery.

Rehabilitation starts immediately after stroke

Stroke care extends beyond emergency treatment. Rehabilitation begins within 24 hours after a stroke when the patient is medically stable. A team of specialists, including neurologists, physiotherapists, and speech therapists, works together to help the patient regain function, rebuild confidence and return to everyday activities as soon as possible.

Physical Therapy to Rebuild Body Movement and Independence

When a stroke happens, muscles on one side of the body may become weak or paralysed, affecting the patient's strength, balance, coordination, posture, and walking.

Physiotherapy consists of a series of exercises, muscle training and mobility techniques that enhance mobility of the body and improve functional independence. Many patients can perform activities with greater ease with regular rehabilitation.

Also read: Weekend Workouts: Why Sudden Intense Exercise May Put Stress on Your Heart

Enhancing communication and cognitive skills

After a stroke, some patients have problems talking, speaking, swallowing, remembering or concentrating. Speech and language therapy are used to help with communication and safe swallowing, and cognitive rehabilitation is used to support memory, attention, reasoning and problem solving. These therapies assist patients in re-entering the workforce, social circles and independent living more smoothly.

Modern Rehabilitation Methods for Better Recovery

Advances in rehabilitation have expanded the range of therapies available to support stroke recovery.

Techniques like robot-assisted rehabilitation, functional electrical stimulation (FES), virtual reality-based therapy, constraint-induced movement therapy, balance training systems and computer-assisted gait training complement conventional rehabilitation very well. These methods provide repetitive, targeted exercises that promote functional improvement in the brain and body.

Managing Ongoing Challenges

After a stroke, some patients have muscle stiffness (spasticity), chronic pain or trouble walking or moving their hands. They are treated with medications, injections and continued rehabilitation therapy.

Recovery from a stroke is much better with proper rehabilitation. While some regain most of their abilities, others continue to need support, making patience and consistency just as important as medical help. The right care at the right time makes a big difference in rebuilding your life.

By Dr. (Lt Gen) CS Narayanan, VSM, Chairman - Manipal Institute of Neuro Sciences, Manipal Hospital, Dwarka, New Delhi