Stress is an unavoidable part of life, and while it often carries a negative connotation, it is actually a fundamental survival mechanism. When faced with a perceived threat, whether physical or emotional, the body instinctively reacts to protect itself. This automatic response is commonly known as the "fight, flight, or freeze" response. While it serves an essential function in dangerous situations, chronic activation of this response due to daily stressors can have significant consequences for mental and physical health.

The body’s response to stress is rooted in human evolution. When our ancestors encountered a predator, their nervous systems immediately prepared them to either confront the threat (fight), escape to safety (flight), or become still and unnoticed (freeze). While modern-day stressors may not include wild animals, our nervous system reacts similarly to job pressures, financial worries, or social conflicts.

According to the Cleveland Clinic, stress is the body's response to change, activating a physiological reaction that helps us adapt and protect ourselves. While short-term stress can be beneficial, prolonged exposure can lead to an overactive stress response, negatively impacting overall well-being.

The Three Stress Responses: Fight, Flight, and Freeze

1. Fight

The fight response prepares the body for direct action. When triggered, the nervous system releases adrenaline, increasing heart rate, blood pressure, and muscle tension. While this reaction once helped early humans fend off predators, today it manifests as irritability, frustration, or aggression.

For instance, the employee who has experienced too much workload may work extremely long hours just to succeed. In short term, the action may produce good results but mostly ends in burnout, anxiety, and physical illness, for example, tension headache or digestion problems.

2. Fight

The flight response triggers an intense need to remove oneself from a stressful situation. Just as our ancestors would flee from danger, modern individuals may avoid conflict, quit jobs impulsively, or detach from relationships when overwhelmed.

Flight mode is linked with restlessness and anxiety. Individuals may have a sense of needing to get up and go-pacing, changing environments constantly, or avoiding tasks that seem too overwhelming. Someone with a flight response might have the desire to change jobs constantly, relocate constantly, or become reclusive in order to avoid perceived dangers.

3. Freeze

The freeze response occurs when the nervous system perceives a threat as too overwhelming to fight or flee. Rather than taking action, individuals shut down, feeling numb, disconnected, or paralyzed by fear.

Unlike fight or flight, which involve heightened activation, freeze mode slows down physiological functions. A person experiencing freeze mode may feel physically unable to move, struggle to make decisions, or find themselves dissociating from their emotions. This can manifest in situations such as public speaking anxiety, where someone might "blank out" or feel stuck in the moment.

What Happens in the Body During A Stressful Event?

When faced with a stressor, the autonomic nervous system (ANS) activates, triggering physiological changes, including:

• Increased heart rate and breathing: The body pumps more oxygen to muscles and the brain in case action is needed.
• Muscle tension: The body prepares for movement, sometimes causing trembling or stiffness.
• Dilated pupils: Vision sharpens to detect potential threats.
• Dry mouth: Saliva production decreases as the body redirects energy to essential functions.
• Changes in skin tone: Blood flow is directed to vital organs, sometimes making the skin appear pale or flushed.

For those experiencing the freeze response, the body undergoes a different reaction, often reducing heart rate and causing physical immobility rather than heightened activation.

Strategies for Coping and Managing the Stress Response

While the stress response is necessary for survival, frequent activation due to daily stressors can take a toll on health. Recognizing your default response—whether fight, flight, or freeze—can help in developing effective coping mechanisms.

1. Moving to a Safe Space

If possible, changing your environment can help signal to your brain that the threat has passed. Stepping outside for fresh air, finding a quiet place, or distancing yourself from overwhelming stimuli can help regulate emotions.

2. Practicing Controlled Breathing

Deep, slow breathing can be used to counteract the stress response by engaging the parasympathetic nervous system, which promotes relaxation. Techniques such as diaphragmatic breathing or the 4-7-8 method (inhale for four seconds, hold for seven, exhale for eight) can be particularly effective in calming the body.

3. Engaging in Physical Activity

This helps release pent-up energy and aids in the endorphin cascade, natural boosters for our mood.

4. Seeking Social Support

Relieving oneself from stress can come in many ways, but sharing it with trusted friends, a family member, or a good therapist will sure give that psychological boost of hope. Social support is an especially effective way of cushioning people against the stressors that they are subjected to in chronic forms.

When to Seek Professional Help

While occasional stress is normal, chronic activation of the fight, flight, or freeze response can indicate underlying mental health concerns, such as anxiety disorders or post-traumatic stress disorder (PTSD). If stress is affecting daily life—leading to sleep disturbances, difficulty concentrating, or persistent feelings of fear—it may be time to consult a mental health professional.

World Thalassemia Day is observed every year on May 8 to raise awareness about the inherited blood disorder caused by faulty genes.

The day was initiated in 1994 by the Thalassaemia International Federation in memory of George Englezos, the son of the federation’s founder, who succumbed to the disease.

This year’s theme, “Together for Better Care and Equal Access,” highlights the need for universal screening, safe blood availability, and advanced therapies.

The disorder, which often requires blood transfusions every fortnight, affects approximately 1.3 million people living with severe forms of thalassemia worldwide. About 1.5 percent of the global population is carriers, and the disease claims nearly 11,000 lives annually.

More than 40,000 infants are born each year with severe thalassemia, predominantly in low- and middle-income countries. Although mortality rates have declined, they remain high in developing regions, particularly in Southeast Asia.

What Is Thalassemia?

Thalassemia is an inherited hemoglobin disorder caused by defective synthesis of alpha or beta globin chains.

In β-thalassemia major, reduced or absent beta-chain production leads to ineffective erythropoiesis, severe anemia, bone marrow expansion, splenomegaly, growth retardation, and iron overload due to repeated blood transfusions.

Patients often present in early childhood with pallor, jaundice, recurrent infections, and characteristic facial bone deformities.

Thalassemia Screening

With 10,000–15,000 babies born with Thalassemia Major every single year in India, the country remains one of the global hotspots for the blood transfusion-dependent disease.

HealthandMe spoke to doctors who emphasized that carrier screening, premarital counseling, and antenatal diagnosis remain crucial preventive strategies in India, often referred to as the “thalassemia capital of the world”, as nearly one in every eight thalassemia patients globally lives in the country.

Experts stressed that normalizing conversations around screening is key to reducing the disease burden.

Dr. Ajay Sharma, Director and Head of Hematology and Hemat-Oncology at Paras Health Panchkula, said thalassemia is a preventable genetic disorder, but continues to go undetected until it is too late.

This is because “thalassemia screening, which is one of the simplest yet most overlooked preventive steps in India,” said Dr. Vishnu Hari, Associate Director and Head of Haematology & BMT at Sarvodaya Hospital, Faridabad.

“Every couple, especially those planning marriage or pregnancy, should undergo basic carrier screening. The challenge is not the availability of tests, but the lack of awareness and social hesitation around genetic conditions,” Dr. Hari said.

Also read: Reused Syringes Infect Over 330 Children in Pakistan With HIV: Report

When To Get Screened?

Screening should ideally be done early, as early detection helps informed decision-making and prevents severe health complications in children. Experts recommend screening:

• At the premarital stage
• At the start of pregnancy

What Will the Screening Find?

Carrier detection is possible with a complete blood count and a test called High Performance Liquid Chromatography (HPLC). Indicators include:

• Low haemoglobin (~9 g/dL)
• Low MCV (Mean Corpuscular Volume, ~65)
• HbA2 levels above 3.5%

“If both partners are carriers, timely genetic counselling during the antenatal phase becomes critical,” he said.

While cultural stigma and low prioritization of preventive healthcare often delay this step, the integration of routine thalassemia screening into premarital check-ups and early pregnancy care can help significantly reduce the number of affected births in India.

What Could Be Done To Manage Thalassemia?

Dr Parveen Yograj, a General Surgeon from Jammu, in a post on the social media platform X, shared that treatment for thalassemia has evolved remarkably over recent decades.

“Regular blood transfusions combined with iron chelation therapy using agents like Deferasirox and Deferiprone have significantly improved survival. Curative therapy through bone marrow transplantation is now increasingly successful, especially in children with matched donors.

"Recent breakthroughs in gene therapy and CRISPR-based genome editing offer new hope for a long-term cure by correcting defective globin gene expression,” he said.

There is a particular cruelty about ovarian cancer. It does not announce itself loudly. Instead, it murmurs softly with a bit of bloating here, some lower back pain there, a persistent sense that something is not quite right, but nothing dramatic enough to cause alarm. And by the time most women receive a diagnosis, the disease has often made itself very much at home.

Every year on May 8th, the world pauses to mark World Ovarian Cancer Day, an occasion that has grown since its launch in 2013 into a genuinely global movement. This year’s theme – ‘No Woman Left Behind’ – carries particular weight because the uncomfortable truth is that far too many women are being left behind by late diagnoses, by underfunded research, and by healthcare systems that have historically paid less attention to this disease than it deserves.

The Numbers We Need to Sit With

Roughly 250,000 women are diagnosed with ovarian cancer every year across the world. An estimated 140,000 will die from it. It is, by some measures, the deadliest of all gynecological cancers, and yet, it receives a fraction of the public attention given to breast cancer.

The comparison is worth dwelling on. Approximately 89 per cent of breast cancer patients survive beyond five years. For ovarian cancer, that figure drops to around 45 per cent – nearly half! And the primary reason for that stark difference is not that ovarian cancer is inherently untreatable but that it is rarely caught in its early stages.

When diagnosed at Stage I before the cancer has spread beyond the ovaries, survival rates climb dramatically, with some studies suggesting above 90 per cent. The problem is that only around 20 per cent of cases are caught that early. The rest are diagnosed at Stage III or Stage IV, when the cancer has already spread to the abdomen, lymph nodes, or beyond.

Why Does It Get Missed?

Ask most people to name the symptoms of ovarian cancer, and you will likely be met with a blank look. That in itself is part of the problem. Unlike the distinct lump in breast cancer cases or the irregular bleeding associated with cervical and uterine cancer, ovarian cancer does not produce one clear and recognizable sign. What it does produce are symptoms that most of us would simply dismiss – persistent bloating, feeling full quickly when eating, pelvic or lower abdominal pain, urge to urinate more frequently or urgently, unexplained fatigue, and a change in bowel habits.

Each of those individually could be attributed to several other conditions, including irritable bowel syndrome, gut infections, stress, dietary changes, and even getting older. That is precisely what makes this disease so dangerous. Women dismiss these symptoms. Sometimes doctors do too.

This is not about blame; it is about recognition. The medical community has made genuine progress in understanding ovarian cancer, but there simply aren’t any reliable early-screening tests available that are similar to mammograms for breast cancer or smear tests for cervical cancer. Hence, genuine and widespread public awareness becomes the closest thing to building a first line of defense.

No Woman Left Behind: A Global Reckoning

The 2026 theme is not merely a slogan. It is a confrontation with the reality that a woman’s place of residence, country, or economic circumstances should not determine whether or not she lives.

In higher-income countries, access to surgery and chemotherapy, whilst still imperfect, is broadly available. Newer treatments are beginning to extend survival times for women with advanced disease. Research into biomarkers is advancing, offering hope for earlier detection in the future.

But in lower-income countries, the picture is vastly different. Women are often diagnosed later, treated less effectively, and supported less comprehensively. The global survival gap for ovarian cancer is not simply a medical problem; it is more a problem of justice.

‘No Woman Left Behind’ asks us to hold that in mind. Progress that only reaches the privileged is not progress enough.

What Women Can Do Right Now

The absence of a reliable screening test makes personal awareness all the more essential. There are several things every woman can do, not just on May 8 but throughout the year.

• Know your body – That phrase risks sounding hollow, but it carries real weight here. If you notice symptoms – particularly if they are new, persistent, and happening more than 12 times a month – do not dismiss them. Note them down and take them seriously.
• Know your family history – Ovarian cancer has a significant genetic component. Mutations in the BRCA1 and BRCA2 genes substantially increase a woman’s lifetime risk. If you have a family history of ovarian or breast cancer, speak to your GP about whether genetic testing might be appropriate for you. Knowledge is not a cause for panic; it is a basis for informed decisions.
• Advocate for yourself – This is perhaps the hardest one to say and the most important. Women have historically been more likely to have their symptoms dismissed or attributed to anxiety, hormones, or stress. If something does not feel right, go back and ask again. Push for a referral. You are entitled to be taken seriously.
• Talk about it – The single most powerful thing any of us can do is have conversations — with friends, with family members, in offices, and community spaces. The more ovarian cancer is spoken about, the more women will recognize its symptoms. And the more symptoms are recognized early, the more lives can be saved.

The Quiet Power of Collective Action

Since 2013, World Ovarian Cancer Day has grown into a movement that now spans more than 80 per cent of the world’s countries and is supported by over 200 organizations globally. That is an extraordinary thing. It is proof that sustained, collective attention can shift awareness, influence policy, and ultimately change outcomes.

But awareness days only work if they spark something beyond the day itself. The teal ribbons and social media posts matter, not because they are gestures, but because every gesture has the potential to reach someone who needs to hear it, someone whose bloating has been going on for two months, someone whose mother was diagnosed with breast cancer and who has never thought to ask whether their own risk might be elevated. Someone who simply did not know.

Therefore, let us spread awareness this day by realizing that equality is not in regarding different things similarly, equality is in regarding different things differently, and still leaving no one behind.

Many women do not consider persistent bloating to be a serious issue because they tend to correlate their symptoms with acidity, excessive gas, overeating, or other temporary issues caused by their digestive system. Many women tend to treat their symptoms on their own by changing their diet or taking over-the-counter medications without looking into what the underlying problem may be. Many women do this because their symptoms initially seem mild. However, it is important to pay attention to any persistent bloating, especially if the bloating occurs on a regular basis, has lasted for at least one month, or is associated with symptoms such as pelvic discomfort, loss of appetite, an increased feeling of fullness, or irregular bowel habits (diarrhoea, constipation, etc.).

Is persistent bloating a sign of ovarian cancer?

In an interaction with Health and Me, Dr Parnamita Bhattacharya, Gynaecologist at CK Birla Hospitals, CMRI, spoke about the concerns surrounding persistent bloating and whether it is associated with the risk of ovarian cancer.

One of the most significant concerns surrounding persistent bloating is that women can develop ovarian cancer, especially in the early stages, without knowing or having any obvious signs that they have the disease. Because there are no routine screening tests to detect ovarian cancer in the general population, it is critical for women to be on the lookout for any symptoms of persistent bloating and report them immediately to their doctor. Unfortunately, because women often ignore their symptoms and fail to seek medical attention, by the time they do see a doctor, ovarian cancer has progressed to a later stage of development.

How to know if it is digestion-related bloating?

Not all bloating is related to ovarian cancer. Other common contributing factors to bloating include irritable bowel syndrome, food intolerance, hormonal changes, and lifestyle factors. The significant difference between "normal" bloating and "abnormal" bloating is how long each type of bloating lasts and how quickly the symptoms progress. If your bloating continues despite dietary changes, or if it increases in frequency, you should not ignore the symptoms. You should have them evaluated by a medical professional.

It is important for women to understand the signals sent by their bodies. If you frequently experience bloating, this issue needs to be investigated and not just accepted as normal. If you seek timely evaluation, doctors can determine the source of your problem early on, which greatly increases your chances of a good outcome from a serious diagnosis such as ovarian cancer.

What are the symptoms of ovarian cancer?

Ovarian cancer symptoms can be vague and may develop as the disease progresses. Therefore, timely detection is a challenge. Some of the signs of ovarian cancer include:

1. Pain in the pelvic region
2. Swollen belly
3. Loss of appetite
4. Feeling full after small meals
5. Nausea
6. Diarrhoea
7. Constipation
8. Unexpected weight loss
9. Painful sex
10. Extreme fatigue
11. Abnormal vaginal bleeding between periods