Stress is an unavoidable part of life, and while it often carries a negative connotation, it is actually a fundamental survival mechanism. When faced with a perceived threat, whether physical or emotional, the body instinctively reacts to protect itself. This automatic response is commonly known as the "fight, flight, or freeze" response. While it serves an essential function in dangerous situations, chronic activation of this response due to daily stressors can have significant consequences for mental and physical health.

The body’s response to stress is rooted in human evolution. When our ancestors encountered a predator, their nervous systems immediately prepared them to either confront the threat (fight), escape to safety (flight), or become still and unnoticed (freeze). While modern-day stressors may not include wild animals, our nervous system reacts similarly to job pressures, financial worries, or social conflicts.

According to the Cleveland Clinic, stress is the body's response to change, activating a physiological reaction that helps us adapt and protect ourselves. While short-term stress can be beneficial, prolonged exposure can lead to an overactive stress response, negatively impacting overall well-being.

The Three Stress Responses: Fight, Flight, and Freeze

1. Fight

The fight response prepares the body for direct action. When triggered, the nervous system releases adrenaline, increasing heart rate, blood pressure, and muscle tension. While this reaction once helped early humans fend off predators, today it manifests as irritability, frustration, or aggression.

For instance, the employee who has experienced too much workload may work extremely long hours just to succeed. In short term, the action may produce good results but mostly ends in burnout, anxiety, and physical illness, for example, tension headache or digestion problems.

2. Fight

The flight response triggers an intense need to remove oneself from a stressful situation. Just as our ancestors would flee from danger, modern individuals may avoid conflict, quit jobs impulsively, or detach from relationships when overwhelmed.

Flight mode is linked with restlessness and anxiety. Individuals may have a sense of needing to get up and go-pacing, changing environments constantly, or avoiding tasks that seem too overwhelming. Someone with a flight response might have the desire to change jobs constantly, relocate constantly, or become reclusive in order to avoid perceived dangers.

3. Freeze

The freeze response occurs when the nervous system perceives a threat as too overwhelming to fight or flee. Rather than taking action, individuals shut down, feeling numb, disconnected, or paralyzed by fear.

Unlike fight or flight, which involve heightened activation, freeze mode slows down physiological functions. A person experiencing freeze mode may feel physically unable to move, struggle to make decisions, or find themselves dissociating from their emotions. This can manifest in situations such as public speaking anxiety, where someone might "blank out" or feel stuck in the moment.

What Happens in the Body During A Stressful Event?

When faced with a stressor, the autonomic nervous system (ANS) activates, triggering physiological changes, including:

• Increased heart rate and breathing: The body pumps more oxygen to muscles and the brain in case action is needed.
• Muscle tension: The body prepares for movement, sometimes causing trembling or stiffness.
• Dilated pupils: Vision sharpens to detect potential threats.
• Dry mouth: Saliva production decreases as the body redirects energy to essential functions.
• Changes in skin tone: Blood flow is directed to vital organs, sometimes making the skin appear pale or flushed.

For those experiencing the freeze response, the body undergoes a different reaction, often reducing heart rate and causing physical immobility rather than heightened activation.

Strategies for Coping and Managing the Stress Response

While the stress response is necessary for survival, frequent activation due to daily stressors can take a toll on health. Recognizing your default response—whether fight, flight, or freeze—can help in developing effective coping mechanisms.

1. Moving to a Safe Space

If possible, changing your environment can help signal to your brain that the threat has passed. Stepping outside for fresh air, finding a quiet place, or distancing yourself from overwhelming stimuli can help regulate emotions.

2. Practicing Controlled Breathing

Deep, slow breathing can be used to counteract the stress response by engaging the parasympathetic nervous system, which promotes relaxation. Techniques such as diaphragmatic breathing or the 4-7-8 method (inhale for four seconds, hold for seven, exhale for eight) can be particularly effective in calming the body.

3. Engaging in Physical Activity

This helps release pent-up energy and aids in the endorphin cascade, natural boosters for our mood.

4. Seeking Social Support

Relieving oneself from stress can come in many ways, but sharing it with trusted friends, a family member, or a good therapist will sure give that psychological boost of hope. Social support is an especially effective way of cushioning people against the stressors that they are subjected to in chronic forms.

When to Seek Professional Help

While occasional stress is normal, chronic activation of the fight, flight, or freeze response can indicate underlying mental health concerns, such as anxiety disorders or post-traumatic stress disorder (PTSD). If stress is affecting daily life—leading to sleep disturbances, difficulty concentrating, or persistent feelings of fear—it may be time to consult a mental health professional.

In a significant step toward advancing xenotransplantation—the transplantation of organs or tissues from animals into humans—in India, a dedicated department has been established, with research and regulatory work underway. The country’s first animal-to-human organ transplant could follow, subject to government approval and the establishment of legal and ethical guidelines.

The initiative aims to help bridge the organ shortage in the country, Dr. Shikhar Tripathi, Director of the Department of Xenotransplantation Sciences at Sir Ganga Ram Hospital, New Delhi, helming the project, told HealthandMe.

Dr. Tripathi, who has trained with Dr. David K. C. Cooper, a British surgeon-scientist and pioneer of modern xenotransplantation, believes India could perform its first xenotransplant within six months of receiving government permission.

The push comes as xenotransplantation continues to make progress internationally. In 2025, a patient received a genetically engineered pig kidney and lived without dialysis for 271 days before subsequently receiving a human kidney transplant.

India recorded 20,138 organ transplants in 2025, ranking third globally. However, the gap between the demand for and supply of organs remains significant, with deceased-donor donations accounting for a small share of transplants.

Dr. Tripathi estimates India’s annual organ shortage at around 90,000. According to data reported by hospitals and transplant centers on the National Organ and Tissue Transplant Organization (NOTTO) National Registry Portal, the waiting list for major organs stood at 89,839 as of March 3, 2026.

Kidneys accounted for the largest share of patients on the waiting list, followed by livers, hearts, lungs and pancreases.

In an interview with HealthandMe, Dr. Tripathi, who is also working with Dr. Cooper at the Thomas E. Starzl Transplantation Institute in Pittsburgh, US, discussed the scientific barriers, infection risks, regulatory requirements and potential of xenotransplantation in India.

Also read: Pig Kidney Works In Human Body For 271 Days: Why Xenotransplants Could Bridge The Organ Transplant Gap

Q. A pig kidney functioned for 271 days without dialysis in a human. What does this milestone mean for xenotransplantation?

Dr. Shikhar Tripathi: Xenotransplantation has achieved significant milestones, but researchers are still working toward long-term viability. For now, it could serve as a bridge for patients who need an organ while researchers work to address complications and improve graft survival.

“Xenotransplantation has achieved some really significant milestones in the last year or so.”

Q. What are the main barriers to long-term survival of a transplanted animal organ?

Dr. Tripathi: Genetic engineering has helped researchers modify the pig genome to reduce the risk of early rejection. The challenge now is managing late complications, particularly in kidney xenotransplantation.

Two major concerns are proteinuria, or leakage of proteins through the kidney, and thrombotic microangiopathy (TMA), which involves injury to microscopic blood vessels.

“The current barrier we face is late complications of xenotransplantation.”

He added that his group has published research identifying potential pathways involved in proteinuria and TMA and is investigating ways to address these complications.

Read More: World Organ Donation Day 2026: Too Old Or Too Sick To Donate Organs? Doctors Bust Key Myths

Q. What are the infection risks associated with xenotransplantation, and why is lifelong monitoring important?

Dr. Tripathi: One concern is zoonosis, or the transmission of infection from an animal or animal organ to a human. Genetic modifications are intended to address this risk.

“There have been as many as 69 gene edits that have been done by eGenesis,” he said, referring to the company developing genetically engineered organs for transplantation.

Dr. Tripathi believes the risk of zoonotic infection is minimal, but this does not eliminate the risk of infection. Patients also face infections associated with immunosuppression, which is used to prevent their immune systems from rejecting a transplanted organ.

Dr. Tripathi’s group is also working toward accommodation and tolerance, which could allow transplanted organs to function with less immunosuppression.

He said lifelong monitoring of recipients will be needed to track outcomes and ensure continued medical care.

Q. India continues to face a significant organ shortage. How could xenotransplantation help bridge the gap between demand and supply?

Dr. Tripathi: India’s annual organ shortage is around 90,000, and it is increasing. The challenge is not just finding donors but ensuring they are medically fit and compatible with recipients.

He recalled a case in which an 85-year-old father-in-law was willing to donate a kidney to his daughter-in-law, but his age made him unsuitable, and no other family member was a match.

“The question is not whether you have a donor available. It’s also whether your donor is healthy or not,” he said.

He also raised ethical concerns about dependence on deceased-donor organs, arguing that patients should have alternatives that do not depend on another person’s death.

“I think xenotransplantation is not just going to solve a medical problem. It’s going to solve a moral problem,” he said.

READ: India Records 20,138 Organ Transplants In 2025; Deceased Donor Transplants Reach 3,526

Q. What is Sir Ganga Ram Hospital doing to advance xenotransplantation in India?

Dr. Tripathi: The aim is to carry out the first procedure with scientific support and within the necessary legal and ethical framework.

The team is prepared to move forward once the required guidelines are established and government permission is granted.

Q. How soon could India perform its first xenotransplant, and which type of transplant might reach clinical practice first?

Dr. Tripathi: I believe pancreatic islet-cell xenotransplantation could reach clinical practice before whole-organ transplantation.

Islet cells in the pancreas produce insulin, making them a potential area of research for conditions such as type 1 diabetes.

“It’s my scientific belief that islet-cell xenotransplantation would be the first one to hit the clinics,” he said.

As for India’s first xenotransplant, the timeline depends on government approval. “Potentially, six months from the day of the permission, we can perform the first transplant,” he said.

Q. What scientific, regulatory and biosecurity hurdles must India overcome before its first xenotransplant, and what lessons does the 1997 pig-organ transplant case involving Dr. Dhaniram Baruah in Assam offer today?

Dr. Tripathi: India’s first xenotransplant will have scientific, legal and ethical backing, along with patient consent. He said there was no comparison with the 1997 case involving Dr. Dhaniram Baruah in Assam, in which the patient died seven days after the procedure following multiple infections.

“We will not take a single step out of the legal ambit or the ethical ambit,” he said.

Q. Looking ahead five years, could India become a global leader in xenotransplantation?

Dr. Tripathi: India could play a leading international role. “India will be one of the leaders,” he said.

India can also establish its own xenorgan facilities over the next five to eight years. Until then, transporting organs from overseas companies could be an option, provided a secure transportation system is established in coordination with government authorities.

Mostly experienced by women, sexual objectification is a dehumanising tendency that distorts perception of the opposite gender. So researchers from University of Exeter have attempted to curb through physical intervention.

A new study, published in journal Social Neuroscience, suggests that it may be possible to change how people perceive sexualised images of women, at least temporarily.

Researchers at the University of Exeter found that ten minutes of mild electrical stimulation to the scalp could remove bias linked to sexual objectification of women.

It improved participants’ ability to recognise upright images of sexualised female models. It also removed the difference in the way such images of women and men were processed by the participants. Researchers associated that visual pattern with sexual objectification.

“Sexual objectification means treating a person as a body to be looked at or used, rather than as a whole person. It’s dehumanising and most often experienced by women,” said Professor Ciro Civile, author who led the research.

How Did the Experiment Work?

The study included 76 students, including 54 women and 22 men. Participants were asked to memorise photographs of male and female models wearing underwear in sexualised poses. The images were presented both upright and upside down.

They were subsequently shown a mixture of previously seen and new images and asked to identify the models they recognised.

Half the participants received ten minutes of mild electrical stimulation through two electrodes placed on the scalp. The other half received a sham treatment involving just 30 seconds of stimulation. Neither the participants nor the experimenters knew who had received the active stimulation.

The technique, called transcranial direct current stimulation (tDCS), uses a weak electrical current to influence brain activity. Participants generally experienced a mild sensation like tingling.

Also read: Experimental Male Contraceptive Pill May Immobilise Sperm, Work Within 30 Minutes & Give Protection For 8 Hours

Results After Brain Stimulation

People typically recognise faces and bodies more easily when they are upright than when they are upside down. This is called the inversion effect. It reflects the brain’s ability to process a person as a whole, rather than as a collection of separate features.

Previous research has found that this upright recognition feature is smaller for sexualised images of women than for images of men. Researchers interpret this difference as a sign that sexualised female bodies are being processed more like objects.

In the new study, participants who received the sham treatment showed this pattern. Those who received active stimulation, however, became better at recognising upright images of women, and there was no significant difference between the processing of male and female images.

Civile said, “Our findings are initial evidence that the way our visual system processes sexualised images of women can be changed, at least temporarily, by mildly stimulating the brain.”

He added, “This was a lab study – we didn’t measure attitudes or behaviour, and brain stimulation is no cure for sexism – but it gives us a new way to study how objectification works.”

Also read: Can Mental Health Improvement Help Lower High Blood Pressure? Study Points Towards 3 Habits

Can Electrical Stimulation Reduce Sexism?

The experiment basically measured performance on a specific visual-recognition task, not participants’ beliefs, behaviour or their outlook on women.

The researchers also tested recognition during stimulation or immediately afterwards. They did not identify how long the change lasted or whether the findings would apply outside the laboratory.

The sample was also small and consisted entirely of university students, so further research is needed to test the findings in bigger sample sizes

Sexual objectification is behind various harmful outcomes, including body shame, anxiety, eating disorders and greater tolerance of sexual harassment. Understanding how objectifying perceptions arise may help researchers investigate ways to address these sexist biases.

The Indian Meteorological Department has put the coastal states of Andhra Pradesh and Odisha on high alert as Cyclone Arnab is due to make a landfall on Wednesday forenoon.

The department said that a “very severe” cyclonic storm, named Ornab (Arnab), is forming over the Bay of Bengal, nearly 260 km southeast of the port city of Visakhapatnam, the most populous city in Andhra Pradesh.

Nearly 12 million people live on the cyclone’s projected route, which runs inland and north across India, according to Andhra Pradesh’s disaster management authority.

Out of around 400,000, nearly 50,000 people in vulnerable areas have been evacuated to state-run shelters since Monday, according to Reuters. According to The Hindu, around 48,000 people are being mobilised to safer areas in Odisha.

Health Risks After The Storm

Cyclonic storms do not just end when the winds blow away or floodwater recedes. Floodwater may contain human and animal waste, chemicals and decaying organic matter. This could contaminate drinking water.

Contaminated drinking water, damaged sewage systems and stagnant pools can create conditions for waterborne infections and mosquito-borne diseases in the days and weeks that follow.

Exposure may increase the risk of gastrointestinal infections, while contact with contaminated water can also transmit infections like leptospirosis. Additionally, water collected in puddles and blocked drains can turn into breeding sites for mosquitoes.

Dr Divya K S, infectious disease specialist at Apollo Hospitals, Seshadripuram, Bengaluru, told HealthandMe that the health risks that can emerge after Cyclone Arnab, the warning signs to watch for and the precautions people should take.

Risk Of Water-Borne Infections

One of the biggest post cyclone threats is contamination of drinking water sources. Floodwaters can cross into potable water networks and mix with sewage, allowing disease germs to enter water used for drinking, cooking and washing.

Dr Divya warns of the risk posed by acute enteric pathogens, which can cause gastrointestinal illnesses. “Widespread contamination of municipal water and sewage water can cause an increase in pathogens causing gastroenteritis like Cholera, enteric fever etc.,” she says.

She added, “Floodwater is an active biohazard matrix containing human/animal waste, chemicals, and decaying organic matter.”

According to the expert, exposure to these pathogens could lead to different infections: Acute Diarrheal Pathogens: Vibrio cholerae, enterotoxigenic E. coli (ETEC), Salmonella enterica, Shigella spp., Campylobacter, and enteric viruses (Rotavirus, Norovirus) causing acute watery diarrhea and inflammatory dysentery. Leptospirosis: Leptospira shed in rodent urine can penetrate abrasions or mucous membranes.

Contaminated water and food can transmit infections like cholera, enteric fever and other infections like dysentery. Enteric viruses, including norovirus and rotavirus, can also cause diarrhoea.

Symptoms may include diarrhoea, vomiting, abdominal cramps and fever. Severe diarrhoea can lead to dehydration, which is particularly dangerous for young children, older adults and people with underlying health conditions.

People should seek medical attention if they develop bloody diarrhoea, vomiting, severe abdominal pain, high fever, confusion, or other signs of severe dehydration.

Also read: Scrub Typhus Claims 15 Lives In Rajasthan: What To Know About Its Symptoms, Transmission, Treatment & Prevention

Risk Of Vector-Borne Infections

As floodwaters recede, water may collect in puddles, blocked drains and other neglected spaces. These sites can cause mosquito breeding, increasing the risk of diseases like dengue, chikungunya and malaria.

Dr Divya says, “Vector populations surge sharply within 1 to 2 weeks post-cyclone. As floodwaters recede, micro-environments like puddles, discarded containers form ideal sites for mosquito breeding.”

After a cyclone, it is therefore important to remove breeding sites by clearing out stagnant water. Residents should empty discard containers that collect water, clear blocked drains, and avoid water accumulation around their homes.

Also read: Climate Change And Gut Health: How Heat, Drought And Unsafe Water Raise Risks, Global Experts Warn

Who Is The Most Vulnerable After A Storm?

Some people face a higher risk of severe complications because of their age, health conditions or difficulty accessing medical care. Dr Divya identifies the following groups as particularly vulnerable:

• Immunocompromised people: Those with advanced HIV, cancer patients receiving chemotherapy, transplant recipients and people taking immunosuppressive medicines.
• Children and older adults: Both groups may be more vulnerable to dehydration and severe illness.
• Pregnant women: Infections and disruptions in maternity care can pose additional risks.
• People with chronic conditions: Those with diabetes, chronic kidney disease or cardiovascular disease may need uninterrupted access to treatment.

During evacuation, people must carry emergency medicines. Insulin and other temperature-controlled medicines need appropriate storage, while people receiving dialysis, chemotherapy or care related to transplant may need urgent arrangements if services are disrupted.

Pregnant women should continue to access antenatal care and seek urgent help for warning signs like bleeding, severe abdominal pain or reduced fetal movement later in pregnancy.

How To Protect Yourself After The Storm?

Safe drinking water, hand hygiene and food safety are essential after a cyclone, especially when sanitation infrastructure has been damaged.

Dr Divya recommends boiling water to make it safer to drink. “Boiling water can ensure disinfection of the water borne infections,” she says.

The doctor also emphasises hand hygiene and safe food practices. “Rigorous hand hygiene using soap and water prior to food consumption and post-defecation,” she recommends.

Food should be thoroughly cooked and served hot. Avoid raw produce that cannot be washed, food exposed to flies and meals whose handling or storage conditions are unsafe.