Stress is an unavoidable part of life, and while it often carries a negative connotation, it is actually a fundamental survival mechanism. When faced with a perceived threat, whether physical or emotional, the body instinctively reacts to protect itself. This automatic response is commonly known as the "fight, flight, or freeze" response. While it serves an essential function in dangerous situations, chronic activation of this response due to daily stressors can have significant consequences for mental and physical health.

The body’s response to stress is rooted in human evolution. When our ancestors encountered a predator, their nervous systems immediately prepared them to either confront the threat (fight), escape to safety (flight), or become still and unnoticed (freeze). While modern-day stressors may not include wild animals, our nervous system reacts similarly to job pressures, financial worries, or social conflicts.

According to the Cleveland Clinic, stress is the body's response to change, activating a physiological reaction that helps us adapt and protect ourselves. While short-term stress can be beneficial, prolonged exposure can lead to an overactive stress response, negatively impacting overall well-being.

The Three Stress Responses: Fight, Flight, and Freeze

1. Fight

The fight response prepares the body for direct action. When triggered, the nervous system releases adrenaline, increasing heart rate, blood pressure, and muscle tension. While this reaction once helped early humans fend off predators, today it manifests as irritability, frustration, or aggression.

For instance, the employee who has experienced too much workload may work extremely long hours just to succeed. In short term, the action may produce good results but mostly ends in burnout, anxiety, and physical illness, for example, tension headache or digestion problems.

2. Fight

The flight response triggers an intense need to remove oneself from a stressful situation. Just as our ancestors would flee from danger, modern individuals may avoid conflict, quit jobs impulsively, or detach from relationships when overwhelmed.

Flight mode is linked with restlessness and anxiety. Individuals may have a sense of needing to get up and go-pacing, changing environments constantly, or avoiding tasks that seem too overwhelming. Someone with a flight response might have the desire to change jobs constantly, relocate constantly, or become reclusive in order to avoid perceived dangers.

3. Freeze

The freeze response occurs when the nervous system perceives a threat as too overwhelming to fight or flee. Rather than taking action, individuals shut down, feeling numb, disconnected, or paralyzed by fear.

Unlike fight or flight, which involve heightened activation, freeze mode slows down physiological functions. A person experiencing freeze mode may feel physically unable to move, struggle to make decisions, or find themselves dissociating from their emotions. This can manifest in situations such as public speaking anxiety, where someone might "blank out" or feel stuck in the moment.

What Happens in the Body During A Stressful Event?

When faced with a stressor, the autonomic nervous system (ANS) activates, triggering physiological changes, including:

• Increased heart rate and breathing: The body pumps more oxygen to muscles and the brain in case action is needed.
• Muscle tension: The body prepares for movement, sometimes causing trembling or stiffness.
• Dilated pupils: Vision sharpens to detect potential threats.
• Dry mouth: Saliva production decreases as the body redirects energy to essential functions.
• Changes in skin tone: Blood flow is directed to vital organs, sometimes making the skin appear pale or flushed.

For those experiencing the freeze response, the body undergoes a different reaction, often reducing heart rate and causing physical immobility rather than heightened activation.

Strategies for Coping and Managing the Stress Response

While the stress response is necessary for survival, frequent activation due to daily stressors can take a toll on health. Recognizing your default response—whether fight, flight, or freeze—can help in developing effective coping mechanisms.

1. Moving to a Safe Space

If possible, changing your environment can help signal to your brain that the threat has passed. Stepping outside for fresh air, finding a quiet place, or distancing yourself from overwhelming stimuli can help regulate emotions.

2. Practicing Controlled Breathing

Deep, slow breathing can be used to counteract the stress response by engaging the parasympathetic nervous system, which promotes relaxation. Techniques such as diaphragmatic breathing or the 4-7-8 method (inhale for four seconds, hold for seven, exhale for eight) can be particularly effective in calming the body.

3. Engaging in Physical Activity

This helps release pent-up energy and aids in the endorphin cascade, natural boosters for our mood.

4. Seeking Social Support

Relieving oneself from stress can come in many ways, but sharing it with trusted friends, a family member, or a good therapist will sure give that psychological boost of hope. Social support is an especially effective way of cushioning people against the stressors that they are subjected to in chronic forms.

When to Seek Professional Help

While occasional stress is normal, chronic activation of the fight, flight, or freeze response can indicate underlying mental health concerns, such as anxiety disorders or post-traumatic stress disorder (PTSD). If stress is affecting daily life—leading to sleep disturbances, difficulty concentrating, or persistent feelings of fear—it may be time to consult a mental health professional.

As cervical cancer screenings ramp up across the world, a new JAMA study shows that a majority of women prefer clinic-based testing over at-home self-sampling tests in the US.

Researchers from the University of Texas MD Anderson Cancer Center, Houston studied 2,300 women with an average age of 45.5 years. Most were married or living with a partner (58.2 percent), had health insurance (91.9 percent), and had at least some college education (61.6 percent).

Out of those analyzed, over 60 percent preferred clinic-based testing, 20 percent preferred at-home self-sampling tests and over 18 percent were unsure. However, women who had experienced prejudice or discrimination in healthcare were nearly twice as likely to prefer at-home testing.

The study noted that out of the women who preferred at-home testing, nearly 55 percent said it was due to greater privacy, over 35 percent said it was because of a lack of time and over 33 percent noted it was due to fear of embarrassment.

Marginalized women, individuals with low income and individuals who do not trust the health care system were also more likely to prefer at-home self-sampling for cervical cancer screening or not know which option to choose.

To increase screening uptake, the researchers suggested that US officials should incorporate home-based self-sampling as an alternative to clinic-based testing, women’s education and empowerment should be enhanced and tailored interventions focusing on high-risk groups are needed to increase awareness and self-confidence in performing home-based self-sampling.

What Is Cervical Cancer?

Cervical cancer develops in a women's cervix (uterus opening) due to abnormal cell growth, primarily caused by persistent HPV infection, a common infection that's passed through sexual contact.

When exposed to HPV, the body's immune system typically prevents the virus from causing damage however, in a small percentage of people, the virus can survive for years and pave the way for some cervical cells to become cancerous.

Treatment involves surgery, radiation, and chemotherapy, with early detection significantly improving outcomes, though it remains a major cancer in low-income countries Cervical cancer can also be prevented through vaccination and regular screening (Pap/HPV tests).

Symptoms Of Cervical Cancer

Cervical cancer has no symptoms in the early days and therefore, is hard to detect until it has spread. However, the early-stage symptoms include:

• Vaginal bleeding after sex
• Vaginal bleeding post-menopause
• Vaginal bleeding between periods or unusually heavy/long periods
• Watery vaginal discharge with a strong odour or containing blood
• Pelvic pain or pain during intercourse
• Advanced Cervical Cancer Symptoms (when cancer has spread beyond the cervix)
• Painful or difficult bowel movements or rectal bleeding
• Painful or difficult urination or blood in the urine
• Persistent dull backache
• Swelling of the legs
• Pain in the pelvis or lower abdomen

Cervical Cancer: A Growing Crisis In India

As per the World Health Organization (WHO) Director-General Tedros Adhanom Ghebreyesus, about 42,000 new cases of cervical cancer is reported annually in India. This underscores the need for preventive measures such as vaccination and early screening. The country loses one women every eight minutes to cervical cancer.

The WHO Global Strategy to eliminate cervical cancer includes the 90-70-90 targets by 2030 -- vaccinating 90 per cent of girls against HPV, screening 70 percent of women, and ensuring treatment for 90 percent of those diagnosed with cervical disease.

In line with the global strategy to fight cervical cancer, Prime Minister Narendra Modi recently also launched a free HPV vaccination drive that will target health and well-being of adolescent girls in the country.

Union Health Minister JP Nadda has also announced that cervical cancer screenings using Visual Inspection with Acetic Acid (VIA) will now be available at Ayushman Arogya Mandirs and other health facilities for women between 30 and 65 years of age.

"Screening for cervical cancer is now available at 1,81,000 Ayushman Arogya Mandirs, also known as Health and Wellness Centers, across the country as a part of population based screening for early detection and treatment," said Nadda, while addressing a press briefing at the World Health Organization virtually.

Using VIA, a low-cost, point-of-care method, trained health workers will screen women for cervical cancer. Those who test positive will then be referred to higher centers for diagnostic confirmation and further evaluation.

Viagra, a popular erectile dysfunction medication, may be the world's only existing treatment against Alzheimer's disease, according to over 20 experts.

A panel of 21 experts recently combed through anonymous nominations, clinical evidence and found that out of 80 existing medications that show potential in treating the neurodegenerative disorder.

Out of those, Sildenafil (Viagra) ranked first, with Zostavax (a shingles vaccine) and Riluzole (a drug used to treat amyotrophic lateral sclerosis) coming in second and third.

"Each of the priority candidates has evidence supporting relevant underlying mechanisms of action, non-clinical studies, and clinical evidence from epidemiological studies and/or preliminary clinical trials," the researchers wrote in their paper.

"The tolerability of each of these compounds is also suitable for administration to a frailer population of older individuals as part of a well-monitored clinical trial program. We therefore recommend each of these therapeutic approaches as a high priority for clinical trials for the treatment or prevention of Alzheimer's disease."

The researchers found that Viagra may support brain health in several ways. Studies suggest it can promote the growth of nerve extensions (neurites) and reduce abnormal tau protein activity as well as improve blood flow and oxygen supply to the brain.

Previous research also shows that the compound can reduce levels of amyloid-beta (Aβ42) in the hippocampus and lower markers of brain inflammation. Additionally, it can also protect neurons from amyloid-beta damage.

Scientists are yet to determine the exact mechanism behind how Viagra can help protect the brain from Alzheimer's-related damage.

What Is Alzheimer’s Disease?

Alzheimer's disease is one of the most common forms of dementia and mostly affects adults over the age of 65.

About 8.8 million Indians aged 60 and above are estimated to be living with Alzheimer's disease. Over seven million people in the US 65 and older live with the condition and over 100,00 die from it annually.

Alzheimer's disease is believed to be caused by the development of toxic amyloid and beta proteins in the brain, which can accumulate in the brain and damage cells responsible for memory.

Amyloid protein molecules stick together in brain cells, forming clumps called plaques. At the same time, tau proteins twist together in fiber-like strands called tangles. The plaques and tangles block the brain's neurons from sending electrical and chemical signals back and forth.

Over time, this disruption causes permanent damage in the brain that leads to Alzheimer's disease and dementia, causing patients to lose their ability to speak, care for themselves or even respond to the world around them.

While there is no clear cause of Alzheimer's disease, experts believe it can develop due to genetic mutations and lifestyle choices, such as physical inactivity, unhealthy diet and social isolation.

Early symptoms of Alzheimer's disease include forgetting recent events or conversations. Over time, Alzheimer's disease leads to serious memory loss and affects a person's ability to do everyday tasks.

There is no cure for this progressive brain disorder and in advanced stages, loss of brain function can cause dehydration, poor nutrition or infection. These complications can result in death.

Can You Detect Alzheimer's Early On?

The US Food and Drug Administration has approved the use of a blood test which can help diagnose Alzheimer’s disease in adults aged 55 and above.

The blood test, known as Lumipulse, can detect amyloid plaques associated with Alzheimer’s disease and has proven to be a “less invasive option” that “reduces reliance on PET scans and increases diagnosis accessibility.”

FDA Commissioner Martin A. Makary said of the landmark decision, "Alzheimer’s disease impacts too many people, more than breast cancer and prostate cancer combined.

"Knowing that 10 percent of people aged 65 and older have Alzheimer's, and that by 2050 that number is expected to double, I am hopeful that new medical products such as this one will help patients."

It remains unclear when this test will be available for commercial use across the world.

Flo Health, a popular women's health app, has developed new digital tools which could shorten the time for endometriosis diagnosis by more than four years and reduce costs by thousands of dollars per patient across the US.

As of now, endometriosis affects an estimated 190 million of reproductive-age women worldwide, according to the World Health Organization. There is no cure for the chronic condition and access to early diagnosis and effective treatment can take years. Currently, the average time for a diagnosis is between four to 12 years.

However, a new npj Digital Medicine study suggests that Flo Health's Symptom Checker, specifically for endometriosis, alongside standard care could reduce the average time to diagnosis from 7 years to approximately 3 years with about 70 percent accuracy.

The research also found that using the checker allowed women to save $5,196 USD over a 40 year timespan, resulting from reduced medical costs and less productivity loss.

Anna Klepchukova, Chief Medical Officer at Flo Health, emphasized that the goal of such technology is to bridge the gap between symptom onset and clinical intervention.

“Endometriosis can deeply disrupt women’s lives, yet many spend years searching for answers within a system that hasn’t always been designed to connect the patterns they experience over time.

"This research explores how digital tools may help women better recognize their symptoms and bring clearer insights into conversations with their health care providers. While these tools aren't diagnostic, they support earlier awareness and more informed decisions, ultimately changing the trajectory of their care and their lives," she said.

What Is Endometriosis?

Endometriosis occurs when tissue similar to the uterine lining grows outside the uterus, causing pain and other symptoms. According to Dr Anuradha Kapur, Principal Director (Obstetrics & Gynecology) & Head of Unit at Max Smart Super Speciality Hospital, Saket, symptoms can vary widely: “Many experience painful periods, pain during intercourse, bloating, and fatigue.

Others may have irregular bleeding, pain during bowel movements, and even asymptomatic cases,” she notes. Endometriosis is complex and can be difficult to diagnose, especially in asymptomatic cases or when symptoms overlap with other conditions like PCOS.

How Endometriosis Affects Life

Endometriosis can disrupt daily routines, impacting work and relationships due to fatigue and persistent pain. Dr Sonam Simpatwar, a reproductive medicine specialist at Central Railway Hospital, Byculla, Mumbai, highlights the importance of staying alert to symptoms, especially for those with risk factors like family history or high estrogen levels.

“Symptoms can be subtle, and many women may not experience severe signs until they face issues like infertility,” she noted.

For some, managing endometriosis involves lifestyle changes, pain management, and treatments ranging from hormonal therapies to surgical options. Regular gynaecological check-ups are crucial for catching signs early and avoiding long-term complications.

The PCOS and Endometriosis Connection

PCOS, or Polycystic Ovary Syndrome, is often confused with endometriosis due to some overlapping symptoms like irregular menstrual periods.

However, as Dr. Kapur explains, “PCOS doesn’t cause endometriosis. They are distinct conditions with different causes—PCOS results from hormonal imbalances, while endometriosis involves abnormal tissue growth outside the uterus.”

Although they don’t directly cause one another, patients with both conditions face unique challenges, including a higher risk of infertility, irregular cycles, and persistent pain.

Managing PCOS can be equally challenging, particularly because it’s closely tied to insulin resistance and weight. Lifestyle changes, such as a balanced diet and regular exercise, are often recommended, but these suggestions can sometimes become oversimplified, leaving patients feeling body-shamed or unsupported.