Stress is an unavoidable part of life, and while it often carries a negative connotation, it is actually a fundamental survival mechanism. When faced with a perceived threat, whether physical or emotional, the body instinctively reacts to protect itself. This automatic response is commonly known as the "fight, flight, or freeze" response. While it serves an essential function in dangerous situations, chronic activation of this response due to daily stressors can have significant consequences for mental and physical health.

The body’s response to stress is rooted in human evolution. When our ancestors encountered a predator, their nervous systems immediately prepared them to either confront the threat (fight), escape to safety (flight), or become still and unnoticed (freeze). While modern-day stressors may not include wild animals, our nervous system reacts similarly to job pressures, financial worries, or social conflicts.

According to the Cleveland Clinic, stress is the body's response to change, activating a physiological reaction that helps us adapt and protect ourselves. While short-term stress can be beneficial, prolonged exposure can lead to an overactive stress response, negatively impacting overall well-being.

The Three Stress Responses: Fight, Flight, and Freeze

1. Fight

The fight response prepares the body for direct action. When triggered, the nervous system releases adrenaline, increasing heart rate, blood pressure, and muscle tension. While this reaction once helped early humans fend off predators, today it manifests as irritability, frustration, or aggression.

For instance, the employee who has experienced too much workload may work extremely long hours just to succeed. In short term, the action may produce good results but mostly ends in burnout, anxiety, and physical illness, for example, tension headache or digestion problems.

2. Fight

The flight response triggers an intense need to remove oneself from a stressful situation. Just as our ancestors would flee from danger, modern individuals may avoid conflict, quit jobs impulsively, or detach from relationships when overwhelmed.

Flight mode is linked with restlessness and anxiety. Individuals may have a sense of needing to get up and go-pacing, changing environments constantly, or avoiding tasks that seem too overwhelming. Someone with a flight response might have the desire to change jobs constantly, relocate constantly, or become reclusive in order to avoid perceived dangers.

3. Freeze

The freeze response occurs when the nervous system perceives a threat as too overwhelming to fight or flee. Rather than taking action, individuals shut down, feeling numb, disconnected, or paralyzed by fear.

Unlike fight or flight, which involve heightened activation, freeze mode slows down physiological functions. A person experiencing freeze mode may feel physically unable to move, struggle to make decisions, or find themselves dissociating from their emotions. This can manifest in situations such as public speaking anxiety, where someone might "blank out" or feel stuck in the moment.

What Happens in the Body During A Stressful Event?

When faced with a stressor, the autonomic nervous system (ANS) activates, triggering physiological changes, including:

• Increased heart rate and breathing: The body pumps more oxygen to muscles and the brain in case action is needed.
• Muscle tension: The body prepares for movement, sometimes causing trembling or stiffness.
• Dilated pupils: Vision sharpens to detect potential threats.
• Dry mouth: Saliva production decreases as the body redirects energy to essential functions.
• Changes in skin tone: Blood flow is directed to vital organs, sometimes making the skin appear pale or flushed.

For those experiencing the freeze response, the body undergoes a different reaction, often reducing heart rate and causing physical immobility rather than heightened activation.

Strategies for Coping and Managing the Stress Response

While the stress response is necessary for survival, frequent activation due to daily stressors can take a toll on health. Recognizing your default response—whether fight, flight, or freeze—can help in developing effective coping mechanisms.

1. Moving to a Safe Space

If possible, changing your environment can help signal to your brain that the threat has passed. Stepping outside for fresh air, finding a quiet place, or distancing yourself from overwhelming stimuli can help regulate emotions.

2. Practicing Controlled Breathing

Deep, slow breathing can be used to counteract the stress response by engaging the parasympathetic nervous system, which promotes relaxation. Techniques such as diaphragmatic breathing or the 4-7-8 method (inhale for four seconds, hold for seven, exhale for eight) can be particularly effective in calming the body.

3. Engaging in Physical Activity

This helps release pent-up energy and aids in the endorphin cascade, natural boosters for our mood.

4. Seeking Social Support

Relieving oneself from stress can come in many ways, but sharing it with trusted friends, a family member, or a good therapist will sure give that psychological boost of hope. Social support is an especially effective way of cushioning people against the stressors that they are subjected to in chronic forms.

When to Seek Professional Help

While occasional stress is normal, chronic activation of the fight, flight, or freeze response can indicate underlying mental health concerns, such as anxiety disorders or post-traumatic stress disorder (PTSD). If stress is affecting daily life—leading to sleep disturbances, difficulty concentrating, or persistent feelings of fear—it may be time to consult a mental health professional.

In a country where diseases have become a daily topic of discussion, hypertension is gradually increasing behind closed doors. Also referred to as “the silent killer”, this ailment is notorious for making its presence known without symptoms, unlike many health conditions. By the time it is discovered, it may have already begun to affect vital organs.

Diabetes: A Comorbidity Giving Rise to This Vicious Cycle

One of the most prevalent comorbidities of hypertension is diabetes; together, the two create a difficult combination of chronic conditions affecting a patient's overall health. Diabetes causes high blood glucose (sugar) levels that, over time, damage blood vessels by reducing their ability to stretch or expand. When combined with the pressure caused by hypertension, these already compromised blood vessels can deteriorate rapidly, resulting in further damage.

The combined effects of diabetes and hypertension significantly increase the risk of heart-related complications, such as enlargement of the heart muscle, a reduced ability of the heart to pump blood effectively, and heart failure. Thus, the two conditions create a vicious cycle and emphasise the need for prompt diagnosis and treatment.

According to Dr Ameet Soni, AVP Medical Affairs, CORONA Remedies, “Hypertension and diabetes mellitus (DM) are two of the most common cardiometabolic disorders, often occurring together, and each exacerbates the impact of the other. When combined, these conditions significantly increase the risk of complications such as cardiovascular, cerebrovascular, and renal damage, particularly when symptoms are not identified early or when treatment adherence is inadequate. Minimising the risk of these complications depends on early identification, proactive risk assessment before diagnosis, and long-term adherence to treatment regimens for controlling blood glucose levels and blood pressure.”

According to Dr Manoj Chawla, Diabetologist, P.D. Hinduja Hospital and MRC, Khar, Mumbai, “These diseases are also termed ‘silent partners’, indicative of both their association and the silent damage they cause to bodily functions. The connection between these diseases in India is quite common owing to several factors, including a sedentary lifestyle, poor nutrition, obesity, excessive stress, and a lack of proper diagnosis. Individuals suffering from diabetes have twice the risk of developing hypertension compared with healthy individuals. Since both diseases are asymptomatic in many cases, patients may only discover them when complications arise. Early diagnosis of hypertension and diabetes is therefore vital. Tests such as blood pressure and blood glucose monitoring, weight management, proper nutrition, exercise, adequate sleep, and stress management all help to prevent these risks.”

Here are five alarming signs that your hypertension might be linked to diabetes.

1. Frequent Urination and Thirst: One of the earliest signs that hypertension may be associated with diabetes is frequent urination, accompanied by an abnormal increase in thirst. When blood sugar levels are high, the kidneys work overtime to filter and absorb excess sugar, leading to increased urine production. This, in turn, causes dehydration, prompting an increased thirst response.
2. Fatigue and Weakness: If you are experiencing unexplained fatigue or weakness, this could be a sign that your hypertension is coupled with diabetes. High blood sugar levels prevent glucose from entering the cells efficiently, leaving the body depleted of energy. Hypertension, in turn, places additional strain on the heart and circulatory system, leading to a further decline in overall energy levels.
3. Blurred Vision: The eyes are particularly vulnerable to the effects of both high blood pressure and diabetes. High blood sugar levels can damage the blood vessels in the retina, leading to diabetic retinopathy, which can cause blurred vision. Additionally, hypertension can further exacerbate this damage by increasing pressure within the blood vessels, resulting in worsening vision problems.
4. Numbness or Tingling in the Extremities: Diabetic neuropathy, a common complication of diabetes, causes nerve damage, particularly in the hands, feet, and legs. This nerve damage can lead to symptoms such as numbness, tingling or even a burning sensation in the extremities. When hypertension is present alongside diabetes, the blood vessels supplying the nerves may become compromised, exacerbating the symptoms of neuropathy.
5. Elevated Blood Sugar with Uncontrolled Hypertension: If your blood pressure is consistently high despite treatment or lifestyle changes, it could indicate an underlying issue, such as uncontrolled diabetes. Insulin resistance, which is common in type 2 diabetes, can worsen hypertension by increasing blood pressure due to factors such as weight gain and metabolic imbalances. When blood sugar levels are poorly managed, they can interfere with blood pressure regulation.

Early detection and intervention are key to managing both conditions and reducing the risk of complications. If you are experiencing any of the symptoms mentioned above or have a family history of either condition, it is vital to consult your healthcare provider. Regular screenings, lifestyle modifications and adherence to prescribed treatments can help control both hypertension and diabetes, improving your quality of life and preventing long-term complications.

Parkinson’s disease is characterized by slowness of daily activities, rigidity, and tremors with gait issues, commonly seen after the age of 45-50 years.

It is two times more common in men than women, though clinical features, response to the treatment, and prognosis are different in women as compared to men. From subtle early signs to how the condition develops over time, gender can shape the Parkinson’s journey in important ways.

Women usually experience Parkinson’s disease at a later age, but with faster progression of symptoms as compared to men. There is a need for more research in this space; however, we will try to shed light on these differences in Parkinson's trajectories in men and women based on available evidence.

Why Is Parkinson’s Less Common In Women?

Estrogen, a group of primary female sex hormones, is neuroprotective and protects dopaminergic neurons in women; women also have a higher baseline reserve of dopaminergic neurons. Hence, Parkinsonism is less common in women.

In the post-menopausal period, once this estrogen-related neuroprotective effect disappears, Parkinson’s symptoms progress rapidly. Motor symptoms emerge later in women with tremors, rigidity, and gait disturbances being more common and severe. Freezing of gait and postural instability with falls are more common in women.

Differences In Motor vs Non-Motor Symptoms

Non-motor symptoms like pain, fatigue, autonomic disturbances, sleep disorders, constipation, and mood disorders, including depression and anxiety, are more common and severe in women. Men with Parkinson’s disease have worse general cognitive abilities; however, women have worse visuospatial abilities.

Women with Parkinson’s receive less social support, lower quality care, attend medical appointments alone, and report more psychological stress. Women have a lower body mass index and higher bioavailability of levodopa, which makes them more susceptible to the side effects of levodopa, such as motor fluctuations and dyskinesia, which entail involuntary movements like fidgeting and writhing.

Why Personalized Treatment Matters

There is a clear need for personalized and tailored treatment. The different and distinctive clinical features in women, like later onset, higher tremors and rigidity, higher dyskinesia and motor fluctuations from drugs, and worse non-motor symptoms, require tailored, sex-specific treatment strategies rather than a “one-size-fits-all” approach.

Clinicians must give importance to the screening and management of non-motor symptoms in women, which are the main factors of their decreased quality of life. Women with this ailment go through longer delays in diagnosis and less access to specialists, highlighting a need for better healthcare access for women.

While HPV vaccines are most known for preventing cervical cancer, a top US doctor says they can also help curb the rising incidence of head and neck cancers.

According to Mikkael A. Sekeres, Chief of the Division of Hematology and Professor of Medicine at the Sylvester Comprehensive Cancer Center at the University of Miami, Human papillomavirus (HPV) — the same sexually transmitted virus that can infect the genital area and lead to cervical cancer — is now the greatest risk factor for head and neck cancer.

Writing in The Washington Post, Sekeres noted that HPV accounts for about 30 per cent of oropharyngeal cancer worldwide.

HPV is believed to be responsible for the recent rise in head and neck cancers, which include malignancies affecting the mouth and throat (oral cavity and pharynx), voice box (larynx), sinuses and nasal cavities, and salivary glands.

Sekeres said the US records about 60,000 new cases of head and neck cancers each year, while the global incidence is expected to rise by 30 per cent by 2030.

What Are The Risk Factors?

The expert noted that men develop oral cavity and pharynx cancers at approximately 2.5 times the rate of women.

Major risk factors include:

• Tobacco use, including smoking, secondhand smoke and smokeless tobacco
• Chewing areca nut, also known as betel quid
• Heavy alcohol consumption
• HPV infection

Also read: PM Modi Launches Nationwide Free HPV Vaccination Drive; A Landmark Step, Says WHO

The Centers for Disease Control and Prevention (CDC) estimates that the high-risk HPV subtypes most associated with head and neck cancers are detectable in the mouths of 4 per cent of adults aged 18 to 69.

While a pap test detects early-stage cervical cancer in women, no such test exists for penile, anal, or head and neck cancers in men, which can worsen their survival rate.

HPV Vaccination Best Prevention Strategy

Thus, Sekeres said: “The best way to prevent the most common types of HPV is through vaccination, with two doses of the vaccine recommended for children at age 11 or 12, or starting as early as 9 years and up to age 26 for those who missed it as a child".

He noted that although the vaccine is approved for use up to age 45, it is generally less beneficial after age 26 because many individuals may have already been exposed to HPV. However, doctors can help determine whether vaccination may still be beneficial for adults.

Earlier this year, the European Cancer Organization also urged broader HPV vaccination regardless of gender.

“HPV affects everyone, regardless of gender. It can lead to cancers of the cervix, mouth and throat, anus and penis. This is why universal protection is so important,” the organization said in a social media post.

Read More: Who Needs HPV Vaccine? Guide For Every Parent, Teen And Adult

HPV Vaccine Can Boost Cancer Risk

A 2026 study published in JAMA Oncology found that boys and men who received the HPV vaccine between the ages of 9 and 26 were nearly 50 per cent less likely to develop cancers of the head and neck, esophagus, anus, or penis.

The findings, based on data of more than 510,000 boys and men, highlight the importance of vaccinating all children and adolescents against HPV, said Taito Kitano, first author of the study and a researcher at Nara Prefecture General Medical Center in Japan.

“Children, adolescents, parents and health care workers should be more informed about the expected benefits of the HPV vaccine, not just cervical cancer,” Kitano said.