According to a study published in the November 6, 2024, online issue of Neurology, the medical journal of the American Academy of Neurology, older people who are sleepy during the day or lose interest in activities due to sleep issues may be more likely to develop a syndrome that can lead to dementia.

People with the syndrome walk slowly and report memory problems, but they do not have a mobility handicap or dementia. Motoric cognitive risk syndrome is a condition that can develop before dementia.

What The Study Found?

The study found that people with excessive daytime sleepiness and a lack of enthusiasm to get things done were more likely to develop the syndrome than people without those sleep-related issues. The study does not prove that these sleep-related issues cause the syndrome, it only shows an association.

“Our findings emphasize the need for screening for sleep issues,” said study author Victoire Leroy, MD, PhD, of Albert Einstein College of Medicine in the Bronx, New York. “There’s potential that people could get help with their sleep issues and prevent cognitive decline later in life.”

How Was It Conducted?

The study included 445 participants, with an average age of 76, who did not have dementia. Participants completed sleep surveys at the beginning of the trial. They were queried about memory problems, and their walking pace was measured on a treadmill at the beginning of the study and then once a year for the next three years.

The sleep assessment included questions about how frequently people had difficulties sleeping because they woke up in the middle of the night, couldn't fall asleep within 30 minutes, or felt too hot or cold, as well as whether they used sleep aids. The question to assess excessive daytime drowsiness asks how frequently people have had problems remaining awake when driving, eating meals, or were engaged in any other activity.

The Findings

In total, 177 participants fit the category of bad sleepers, whereas 268 satisfied the definition of good sleepers.

At the outset of the trial, 42 participants had motoric cognitive risk syndrome. Throughout the trial, 36 more persons got the condition.

35.5% of patients who experienced extreme daytime sleepiness and a lack of enthusiasm developed the syndrome, compared to 6.7% who did not. After accounting for other factors that could influence the risk of the syndrome, such as age, depression, and other health conditions, researchers discovered that people with excessive daytime sleepiness and a lack of enthusiasm were more than three times more likely to develop the syndrome than those who did not have those sleep-related issues.

“More research needs to be done to look at the relationship between sleep issues and cognitive decline and the role played by motoric cognitive risk syndrome,” Leroy said. “We also need studies to explain the mechanisms that link these sleep disturbances to motoric cognitive risk syndrome and cognitive decline.”

A limitation of the study is that participants reported their own sleep information, so they may not have remembered everything accurately.

The study was supported by the National Institute on Aging.

Psilocybin is the active ingredient found in magic mushrooms, and a new study shows that just one high dose (25 mg) is enough to cause alterations in the brain’s structures and help improve mental health.

The changes could explain why some people report psychological benefits from the experience, revealed the study published in the journal Nature Communications. The study found that the effect may last for up to a month after the experience.

In the study, researchers from the University of California, San Francisco, and Imperial College London argue that the effect may lead to “subsequent improvements in mental health”.

"Psychedelic means 'psyche-revealing,' or making the psyche visible," said senior author Robin Carhart-Harris, Professor of Neurology at UCSF.

"Our data shows that such experiences of psychological insight relate to an entropic quality of brain activity and how both are involved in causing subsequent improvements in mental health. It suggests that the trip—and its correlates in the brain—is a key component of how psychedelic therapy works," Carhart-Harris added.

How A Psychedelic Trip Improved Brain Health

Psilocybin has been the subject of several studies in people that have found it appears to alleviate symptoms of depression and anxiety. It has also shown promise in addiction medicine.

In the latest study on 28 people, none had a diagnosed mental health condition. The team gave the participants a 1 mg dose of psilocybin, which the researchers regarded as a placebo, and then monitored them with electroencephalography (EEG), which records brain activity from electrodes on the scalp.

One month after the placebo, the subjects were given 25 mg of psilocybin, a dose capable of eliciting a strong psychedelic trip.

After each experiment, the researchers measured the participants’ psychological insight, well-being, and cognitive ability. They also examined brain activity with functional MRI (fMRI) and brain connectivity with diffusion tensor imaging (DTI).

The results showed that within 60 minutes of taking the 25 mg dose of psilocybin, the EEG revealed higher entropy — which means that the brain was processing a richer body of information under the psychedelic.

A month later, the researchers looked at their subjects' brains with DTI, which measures the diffusion of water along neural tracts in the brain, and found that they were denser and had more integrity. This is the opposite of what happens in aging, which makes these tracts more diffuse.

Also Read: Ibogaine: Why Donald Trump Is Pushing US FDA To Fast-track This Psychedelic

While the result is a never-before-seen sign of how psychedelics can change the brain, the researchers cautioned that more work needs to be done to better understand the meaning of this change.

The participants noted that they had experienced more psychological insight after taking the 25 mg of psilocybin than they had after the 1 mg placebo, and noted "feeling optimistic about the future".

A month after the study, they also did better on a test of cognitive flexibility.

"Psilocybin seems to loosen up stereotyped patterns of brain activity and give people the ability to revise entrenched patterns of thought," said Taylor Lyons, a research associate at Imperial College London and the first author of the paper. "The fact that these changes track with insight and improved well-being is especially exciting."

The findings could improve treatment for people with mental illness with psilocybin, for example, by ensuring that the right dosage is used to produce the right amount of brain entropy to promote insight.

Every year on May 5, World Asthma Day is observed, an event that aims at spreading awareness about the respiratory disorders. While asthma is becoming a common occurrence in India, citing excessive pollution and unhealthy lifestyle choices. But in a shocking revelation on the occasion, Dr. Gitika Sanodia, Consultant Dermatologist at Dr L H Hiranandani Hospital, Powai, revealed that leaving eczema untreated could lead to chronic asthma. Talking about it, Dr Sanodia answered some common FAQs about eczema and asthma.

Can untreated eczema cause asthma?

Yes, especially for those suffering from early childhood onset of moderate/severe atopic dermatitis. Eczema is not always limited to being solely a skin condition. In many cases, patients who suffer from eczema actually have one part of the atopic triad, which means the patient's skin barrier is dysfunctional, allowing for allergens to enter and sensitize the immune system. With time, the same tendency can impact other organs, causing allergic rhinitis or asthma. However, it must be noted that not all children with eczema develop asthma.

Why does everybody treat eczema as merely a skin problem?

Because of symptoms including itching, dryness, redness, scaling, and oozing from the skin. The families take care to control the acute phase of eczema while ignoring the patient's predisposition to allergies. Furthermore, atopic dermatitis is an inflammatory skin condition that is accompanied by impaired skin barrier function, immune dysfunction, and environmental factors. Moreover, according to DermNet, atopy is a term used for conditions where eczema, rhinitis, and asthma happen together.

Early signs for which parents and adults should be vigilant

Parents should worry if their children with eczema exhibit recurrent coughs, wheezing, noisy breathing, difficulties breathing during playtime, nighttime coughing, chest tightness, frequent sneezing, nasal blockage, allergic rhinitis, or exacerbation of symptoms following exposure to dust, animal dander, pollens, airborne particles, or fluctuating environmental conditions.

Is eczema therapy sufficient to prevent the development of asthma?

Successful treatment of eczema can help minimize the chances of allergens penetrating the skin barrier and allergic inflammation. Nonetheless, it would not be accurate to predict with certainty that eczema therapy will effectively prevent the onset of asthma. Literature recommends the prompt restoration of the skin barrier function, regular application of moisturizing agents, avoiding triggers such as fragrances and harsh soaps, managing flare-ups with prescription corticosteroid creams, controlling infections, and referring patients with severe eczema cases.

Is it a significant public health concern?

Yes. This condition is becoming more common, especially among children. If not controlled effectively, eczema will result in poor sleeping habits, difficulties with academic performance, reduced quality of life, greater susceptibility to infections, and potentially even links to other allergies. People lack sufficient information regarding the condition because they normally medicate themselves by applying whatever ointment or steroid to their skin.

Asthma is often thought of as an "outdoor" problem, with triggers such as smog, pollen, or car exhaust. But for many, the real danger may be sitting right there on the sofa or hiding under the sink.

The chronic condition affects over 260 million people. It is also responsible for over 450,000 deaths each year worldwide.

If you're doing everything right with your inhaler but still feel that tightness in your chest, it’s time to look at silent indoor triggers.

1. The Bedding "Dynasty"

“It’s a bit unsettling, but your mattress is likely home to millions of microscopic dust mites. They love the warmth and humidity of a bed. You won't see them, but you’ll feel them,” Dr. Sandeep Nayar, Principal Director & HOD - Chest & Respiratory Diseases, BLK Max Super Speciality Hospital, told HealthandMe.

The Fix: Don’t just wash your sheets; use hot water (60°C). If you haven't encased your pillows in allergen-proof covers yet, make that your priority this weekend.

2. Moisture is the Enemy

Dr Nayar said mold isn't always a giant green patch. It hides in the "sweat" behind your wallpaper or the damp corners of a bathroom that doesn't vent well. If a room smells even slightly musty, mold spores are likely in the air.

The Tip: Keep your home's humidity below 50 per cent. A simple dehumidifier can sometimes do more for your lungs than an extra dose of medicine.

3. It’s Not Just the Fur

Many people think "hypoallergenic" pets are the cure. It’s actually a protein in pet saliva and skin flakes (dander) that causes the flare-up.

The Reality: Even if you keep the dog off the bed, dander travels on your clothes. HEPA air purifiers are a must-have if you share your home with a furry friend.

4. The "Clean" Smell Myth

That "fresh lemon" scent or your favorite scented candle? Those are Volatile Organic Compounds (VOCs). To a sensitive lung, those chemicals are irritants, not cleaners.

The Switch: Move toward fragrance-free products. If a cleaning spray makes you cough, your body is telling you everything you need to know.

5. Urban Uninvited Guests

In cities, cockroach droppings are a massive, often ignored asthma trigger. Their proteins mix with household dust and get kicked up every time you walk across the floor.

The Strategy: Seal the cracks in your walls and keep the kitchen bone-dry.

Other asthma triggers include dust mites, pet dander, indoor smoke, and strong cleaning agents that can worsen symptoms over time

How To Prevent Indoor Asthma Triggers

Dr. Manisha Mendiratta, Director & Head - Pulmonology, Sarvodaya Hospital, Faridabad, told HealthandMe that the key is prevention through simple, consistent habits. To make a meaningful difference, the expert urged people to

• ensure good ventilation,
• reduce indoor humidity,
• clean soft furnishings regularly,
• avoid aerosol-based products.
• ise air purifiers,
• keep windows open when possible,
• creating a smoke-free space.

“Most importantly, patients should identify their personal triggers and act early, because managing their indoor environment is just as critical as managing their medication,” added Dr. Mendiratta.