Daytime Sleepiness and Lack of Enthusiasm May Signal Early Dementia Risk

Updated Nov 9, 2024 | 02:00 AM IST

SummaryPeople with the syndrome walk slowly and report memory problems, but they do not have a mobility handicap or dementia. Motoric cognitive risk syndrome is a condition that can develop before dementia.
Dementia

According to a study published in the November 6, 2024, online issue of Neurology, the medical journal of the American Academy of Neurology, older people who are sleepy during the day or lose interest in activities due to sleep issues may be more likely to develop a syndrome that can lead to dementia.

People with the syndrome walk slowly and report memory problems, but they do not have a mobility handicap or dementia. Motoric cognitive risk syndrome is a condition that can develop before dementia.

What The Study Found?

The study found that people with excessive daytime sleepiness and a lack of enthusiasm to get things done were more likely to develop the syndrome than people without those sleep-related issues. The study does not prove that these sleep-related issues cause the syndrome, it only shows an association.

“Our findings emphasize the need for screening for sleep issues,” said study author Victoire Leroy, MD, PhD, of Albert Einstein College of Medicine in the Bronx, New York. “There’s potential that people could get help with their sleep issues and prevent cognitive decline later in life.”

How Was It Conducted?

The study included 445 participants, with an average age of 76, who did not have dementia. Participants completed sleep surveys at the beginning of the trial. They were queried about memory problems, and their walking pace was measured on a treadmill at the beginning of the study and then once a year for the next three years.

The sleep assessment included questions about how frequently people had difficulties sleeping because they woke up in the middle of the night, couldn't fall asleep within 30 minutes, or felt too hot or cold, as well as whether they used sleep aids. The question to assess excessive daytime drowsiness asks how frequently people have had problems remaining awake when driving, eating meals, or were engaged in any other activity.

The Findings

In total, 177 participants fit the category of bad sleepers, whereas 268 satisfied the definition of good sleepers.

At the outset of the trial, 42 participants had motoric cognitive risk syndrome. Throughout the trial, 36 more persons got the condition.

35.5% of patients who experienced extreme daytime sleepiness and a lack of enthusiasm developed the syndrome, compared to 6.7% who did not. After accounting for other factors that could influence the risk of the syndrome, such as age, depression, and other health conditions, researchers discovered that people with excessive daytime sleepiness and a lack of enthusiasm were more than three times more likely to develop the syndrome than those who did not have those sleep-related issues.

“More research needs to be done to look at the relationship between sleep issues and cognitive decline and the role played by motoric cognitive risk syndrome,” Leroy said. “We also need studies to explain the mechanisms that link these sleep disturbances to motoric cognitive risk syndrome and cognitive decline.”

A limitation of the study is that participants reported their own sleep information, so they may not have remembered everything accurately.

The study was supported by the National Institute on Aging.

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‘Smoking Helped Me Lose Weight’—But It May Be Raising Your Type 2 Diabetes Risk

Updated Sep 15, 2025 | 09:00 PM IST

SummarySmoking is a habit that is much more common than you may realize. Although many people know that it can cause lung cancer, they chose to take the risk. However, that is not the only risk you are putting your body in when you smoke. Your smoking can trigger a type of diabetes. Here’s how.
‘Smoking Helped Me Lose Weight’—But It May Be Raising Your Type 2 Diabetes Risk

(Credit- Canva)

If you smoke or around people who smoke, you may have heard them exclaim how smoking makes them lose appetite and helps them lose weight. If you are a person who struggles with weight gain, this logic may appeal to you, however, it could affect you in a completely different way than you realize. Type 2 diabetes is more common than you may realize, more than 38 million Americans have diabetes and 90% to 95% of them have type 2 diabetes (CDC data).

One of the best ways to contain type 2 diabetes is by losing weight. If you think that smoking could be a way to lose this weight, you may want to re-think that.

New research suggests that smoking increases the risk of developing type 2 diabetes, regardless of the specific subtype a person might have. This study, which combines data from Sweden, Norway, and Finland, also found that people with a genetic risk for diabetes are even more vulnerable to the negative effects of smoking.

What Are The Sub-Types of Type 2 Diabetes?

Type 2 diabetes is not a one-size-fits-all condition. Researchers have proposed that it can be broken down into four distinct subtypes, each with different characteristics and health risks.

  • SIRD (Severe Insulin-Resistant Diabetes): The body's cells do not respond well to insulin.
  • SIDD (Severe Insulin-Deficient Diabetes): The body does not produce enough insulin.
  • MOD (Mild Obesity-Related Diabetes): Linked to obesity, often starting at a younger age.
  • MARD (Mild Age-Related Diabetes): Develops later in life.
While the severity and complications differ among these subtypes, it was previously unclear if they shared the same risk factors.

How Does Smoking Affect Diabetes?

The study, which analyzed data from over 3,300 people with type 2 diabetes and almost 3,900 healthy individuals, found a strong connection between smoking and all four diabetes subtypes.

Increased Risk for All Subtypes

People who had ever smoked (current and past smokers) were at a higher risk of developing any of the four diabetes subtypes compared to non-smokers.

What Diabetes Was Linked To Smoking?

The connection was particularly strong for SIRD, the type of diabetes where the body resists insulin. Smokers were more than twice as likely (2.15 times) to develop SIRD than non-smokers. Smoking was also responsible for over a third of all SIRD cases in the study.

Heavy Smoking Increases Risk Further: Heavy smokers (those who smoked at least 20 cigarettes a day for 15 years) had an even higher risk for all four subtypes, with the risk for SIRD being 2.35 times higher than for non-smokers.

Smokeless Tobacco: The study also found a link between heavy use of snus (a smokeless tobacco product) and an increased risk of the more severe diabetes subtypes (SIRD and SIDD) in men.

Could Your Genetics Put You At Higher Risk of Diabetes?

The research also explored how smoking affects people who are already at a high genetic risk for diabetes. The findings showed that heavy smokers with a genetic predisposition for poor insulin production were particularly vulnerable. For example, a heavy smoker with a high genetic risk for impaired insulin secretion was over three times more likely (3.52-fold) to develop SIRD compared to a person without these risk factors.

The study's overall conclusion is clear: smoking raises the risk of type 2 diabetes, regardless of which subtype a person is prone to developing.

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H3N2 Flu On The Rise In Delhi: Symptoms And Precautions You Must Know

Updated Sep 15, 2025 | 06:01 PM IST

SummaryDelhi is currently witnessing a rise in H3N2 influenza cases, a strain of the influenza A virus. Hospitals across the city have issued alerts, and doctors are advising residents to stay vigilant, monitor for symptoms, and seek medical attention at the first signs of illness.
H3N2 SYMPTOMS

Credits: Canva

If you are in Delhi-NCR and have recently been coughing, sneezing, or running a fever, you are not alone. A recent LocalCircles survey shows that 69 per cent of households in the region currently have one or more members experiencing Covid, flu, or viral fever-like symptoms.

The report, titled “Viral illnesses soar in Delhi NCR as 69% households surveyed confirm one or more members experiencing symptoms,” highlights a sharp increase from 54 per cent in March 2025 to 69 per cent now. Here’s a closer look at the H3N2 virus, its symptoms, and the precautions you should take.

What Is the H3N2 Virus?

H3N2 is a subtype of the influenza A virus. According to the World Health Organization (WHO), it causes seasonal flu outbreaks and mutates frequently, which makes it more challenging to manage than other flu strains.

The virus spreads rapidly through droplets from coughing, sneezing, or even talking. It can also spread when a person touches contaminated surfaces and then touches their face. H3N2 can be particularly dangerous for young children, the elderly, pregnant women, and people with weakened immune systems. The Centers for Disease Control and Prevention (CDC) warns that in these groups, H3N2 can lead to serious complications such as pneumonia, bronchitis, and hospitalization.

ALSO READ: Global Warming Is Driving a Surge in Dengue Cases, Study Warns

Symptoms of H3N2 Virus to Watch ForAccording to the Indian Council of Medical Research (ICMR), H3N2 has been the predominant strain causing the recent surge in flu cases across India. Data from hospital admissions for Severe Acute Respiratory Infection (SARI) indicates that 50% of these patients tested positive for H3N2.

Common symptoms include:

  • Sudden high fever (often above 38–39°C) with chills
  • Persistent cough and sore throat
  • Severe fatigue, weakness, and body aches
  • Headache and nasal congestion
  • In children: nausea, vomiting, or diarrhea
Many patients report fever lasting more than 5–7 days, with cough persisting even after other symptoms subside.

ALSO READ: West Nile Virus Isn't Over Yet, New Cases In US On Rise

Precautions Against H3N2 Virus

Prevention is key, and National Institute of Health recommend the following measures:

  • Wash hands regularly with soap and water for at least 20 seconds
  • Wear masks in crowded or poorly ventilated areas
  • Cover your mouth and nose when coughing or sneezing; dispose of tissues immediately
  • Avoid close contact with sick individuals; isolate infected household members if possible
  • Keep living spaces well-ventilated
  • Maintain good nutrition, hydration, and adequate rest
  • Consider the seasonal influenza vaccine, which often protects against H3N2 strains—especially important for children, the elderly, and those with chronic illnesses

H3N2 in the United States

The 2017–18 flu season in the U.S. was particularly severe, with the CDC estimating that 41 million people experienced flu symptoms, including 52,000 deaths. However, as of now, no significant H3N2 cases are being reported in the U.S.

The WHO continues to stress that vaccination is the most effective way to prevent influenza, particularly for high-risk groups and their caregivers.

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Higher Dose Of Weight Loss Medicine Is Not Only Safe, But Could Also Be Better For Weight Loss In Obese Adults

Updated Sep 15, 2025 | 05:18 PM IST

SummaryDespite how weight loss medication may look like a magic pill, it has many setbacks that you should consider before you take it. Questioning how effective it is, researchers found that a dose higher than the basic prescription people get for this medication may work better. Here’s what you need to know.

Recently weight loss medication has gained a lot of popularity. Many people are getting these medicines prescribed in order to lose weight; however, it is not as straightforward of a process as we think it is. There are various aspects of it you should know about before you start taking the medication. One of which is that one needs to take it consistently even after they lose weight because they may gain weight back. How effective the medicine is on you also matters.

Whenever it comes to new medication that can majorly alter a person’s lifestyle physique as well as how their body functions, like Ozempic, one has to be very careful with the doses.

While too much of it can trigger health issues, less of it may not give you the desired effect. So, what should a person do when they are not seeing the results they want? A new study shows that a higher dosage than what we currently have approved, could actually help with better weight loss in obese adults.

An international study has found that a higher weekly dose of the drug semaglutide (7.2 mg) is safe and more effective for weight loss than the currently approved dose (2.4 mg). The findings, published in The Lancet Diabetes & Endocrinology, suggest that this higher dose could be a new and powerful option for adults living with obesity, including those who also have type 2 diabetes.

How Much Semaglutide Dosage Helped People Lose Weight?

In adults who do not have diabetes, a 7.2 mg weekly dose of semaglutide led to a significant average weight loss of almost 19%. This is a notable improvement over the 16% weight loss seen with the standard 2.4 mg dose and a 4% loss in the placebo group (who received a dummy treatment).

Almost half of the participants on the higher dose lost 20% or more of their body weight, with about one-third losing at least 25%. These participants also saw improvements in their waist circumference, blood pressure, blood sugar, and cholesterol levels, which are all important for reducing health risks related to obesity.

For adults with obesity and type 2 diabetes, the 7.2 mg dose also showed better results. These individuals experienced an average weight loss of 13%, compared to 10% with the 2.4 mg dose and 3.9% with the placebo. The higher dose also led to significant reductions in blood sugar levels and waist size.

Is It Safe To Take More Semaglutide?

The study found that the higher dose of semaglutide was safe and well-tolerated overall. The most common side effects were gastrointestinal issues, like nausea and diarrhea, and some tingling sensations. However, most of these side effects were manageable, resolved on their own over time, and did not cause people to drop out of the trial. The researchers did not find any increase in serious health problems or severe drops in blood sugar (hypoglycemia) with the higher dose.

Researchers believe this higher dose could help more people achieve their health goals and reduce the worldwide burden of obesity. They also noted that more research is needed to fully understand the long-term benefits and risks.

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