Can Damaged Sperm Lead To Pregnancy Complications?
Pregnancy is usually a time of happiness and hope, but it also brings in the unexpected. While there is much talk placed on the health of the expectant mother, the quality sperm coming from the father could dramatically change the outcome of pregnancy. The latest study suggests the risks of sperm DNA damage, even increasing the risks of complications preeclampsia and birth prematurity.
In a groundbreaking research study conducted by scientists from Lund University in Sweden, scientists discovered that DNA damage in sperm increases the risk almost up to double that of preeclampsia, this is a dangerous condition that may arise during pregnancies characterized by high blood pressure. In addition, DNA anomalies also increase the risk of premature births, and this further entails increased related adverse health outcomes for infants born through such conditions.
The next step would be to find out which group of men respond best to methods to prevent and treat sperm DNA damage, and to test these methods to prevent pregnancy complications," said Dr. Amelie Stenqvist, a lecturer at Lund University. According to this study, a significant message is put forward that paternal health assumes an important role in a successful pregnancy.
It focused its research on men, specifically whose sperm contained high levels of DNA fragmentation. For instance, some 20% to 30% of babies born via in vitro fertilization have fathers whose sperm contains damaged DNA. The DNA fragmentation index, an indicator to assess the percentage of DNA damage in sperm, indicated that when the percentage of sperm with a DFI above 30% was observed, they had almost no chance of resulting in natural conception. Even a DFI greater than 20% showed that the chances of getting pregnant are highly risky as the risk factor for pregnancy complications like preeclampsia is much high.
Uncommon Complications during Pregnancy
The most alarming complication during pregnancy is preeclampsia. It affects approximately 5% to 8% of pregnancies worldwide, which can cause fatal conditions for both the mother and the baby. The new findings now point out that sperm DNA damage may contribute to this condition, especially if it is due to assisted reproductive techniques such as IVF pregnancies. The research found that a DFI above 20% doubled the risk of preeclampsia from a mere 5% to almost 11% per.
Apart from causing preeclampsia, DNA fragmentation in sperm is also known to increase the risk for prematurity. Most premature babies experience respiratory, neurological, and developmental complications. Therefore, some degree of early intervention might be important for prospective parents.
Some of the rarer, though serious complications include placental abruption, which is the separation of the placenta from the uterine wall and intrauterine growth restriction, a condition by which the baby does not grow normally in the womb. These conditions though rare are potentially catastrophic both to the mother and the child. Results from this study may help in establishing the contribution of the father in such pregnancies.
Further study into sperm DNA damage is of urgent interest with regard to its consequences for pregnancy outcomes. According to Professor Aleksander Giwercman of Lund University in the field of Reproductive Medicine, "the analysis of DFI should be introduced as routine test in all fertility clinics.". "It could give answers to couples who are having difficulties with infertility, but our latest result also shows that DFI analysis can be a method to identify high-risk pregnancies, explained Giwercman.
For many, DNA fragmentation in sperm is often treatable. Common causes are oxidative stress, age, smoking, being obese, and infections. Addressing these elements will likely reduce DNA damage in sperm for men, raising the chances for a healthy pregnancy and baby.
Overall, the study importance should take into consideration paternal as well as maternal health towards reaching for a healthy pregnancy. Though DNA fragmentation in the sperm is supposed to increase the risk factors for complications in pregnancies, the advances into novel treatment approaches and tests are likely to alleviate complications in many families. Thus the findings of this study offer optimism and pave a pathway to more holistic fertility treatments in the future.
Credit: Pixabay
In 2025, Andhra Pradesh reported 1,566 scrub typhus cases, and nine suspected deaths, according to data from the Integrated Health Information Platform, Integrated Disease Surveillance Programme (IDSP-IHIP) on 8 December. Followed by Karnataka with 1,870 cases, Tamil Nadu 7,308 cases, and Telangana, 309 cases. Scrub typhus cases have significantly increased from previous year. It is one of the deadliest infections affecting multiple organs, or even death. Early it was relevant to poeple working in fields, new studies show it migrating to human settlements.
Scrub typhus, also known as bush typhus, is a bacterial infection caused by bacteria infection, caused by bacterium Orientia tsutsugamushi. It is spread through bites of infected larval mites, Chiggers.
Most cases of scrub typhus occur in rural areas of Southeast Asia, Indonesia, China, Japan, the Indian subcontinent and northern Australia. Until now, it was believed that chiggers only lurked in the tall grasses of remote paddy fields or dense forests. Due to this, it is commonly known as "farmers' disease", only confined to the fields.
However, new PLOS study data revealed the opposite. The study is led by researchers from Christian Medical College (CMC) Vellore and international collaborators and suggests that the bulk of infections are now even occurring within human settlements.
The study monitored over 32 000 people in Tamil Nadu, which led to the conclusion that agricultural activities, long considered the primary risk factor, were only weakly associated with the disease in high-prevalence areas.
Risk for scrub typhus is significantly higher for those living in clustered houses or homes with fewer rooms. If the micro environment around the residence is unmaintained, gardens are patched, or even the damp corners of a courtyard, it could lead to breeding ground for the mites and the rodents that carry Chiggers.
It was once believed that working-age men were the most affected, but the new study tells otherwise. According to the new data, women over 60 are at the highest risk of infection.
As women spend most of their time in and around the home, due to household work, from the kitchen to the laundry, these activities are now the primary cross point of contact with infected mites.
As initial symptoms of infection, such as fever, headache, and muscle pain, are the same as viral flu or dengue, many first seek help from untrained practitioners or local pharmacies.
By the time they reach the hospital, the disease has already progressed to severe complications like acute respiratory distress syndrome (ARDS), Kidney failure, or Meningoencephalitis, which is inflammation of your meninges and brain at the same time, a life-threatening condition.
Not only this, the researchers revealed that nearly 10 percent of affected households exceed 25 percent of their income in the treatment.
For severe cases, the cost of treatment can be up to approximately INR 110,000, a staggering sum for rural and peri-urban families earning a fraction of that monthly.
Early intervention is necessary, as if a fever lasts more than two days, don't just treat it as "seasonal fever".
Consult a qualified doctor and specifically ask about scrub typhus. Infection can be treated with doxycycline common antibiotic, in the early stages. The case fatality rate in this study was 1.5 percent, hospital based studies in South India have previously recorded mortality rates as high 30 percent when treatment is delayed
Credit: @gynaegirls/Instagram
A now-viral video has revealed how a new mother who believed she had grown excessive fat tissue instead discovered that her body had developed a third nipple under her armpit.
Jasmine, an American woman had given birth five days earlier when a lactation consultant visited her to giver her advice on breastfeeding. The new mother, who was still exhausted and recovering from childbirth, recalled mentioning that her armpits always carried what she believed was excess fat that darkened during pregnancy.
"I breastfed my first baby for one-and-a-half-years, so I'm thinking that there's nothing this nurse can say that's going to surprise me," Jasmine said.
However, after a careful examination, the expert told her that the swelling in her underarm was extra breast tissue and that she also had "a nipple” there.
"When you're pregnant, your nipples and areolas will get really dark, and I have noticed the same change with my armpits, so I was like 'Great! extra breast tissue, I already knew that.' And then the lactation consultant is like 'Let me see,' and I show her, and she goes, 'Oh! yeah... And that's a nipple'.
"You know how cows and puppies and kittens, they have that line of nipples? Yeah, humans have that, too. Tell me why she's telling me about someone that had an extra nipple on her thigh. Telling me I have a third nipple in my armpit before I even had my first postpartum poop is diabolical work,” she said, joking about how little sleep she’d had.
According to Dr Rooma Sinha, an obstetrician and gynaecologist at Apollo Hospitals in Hyderabad, Jasmine's third nipple is known as the axillary tail of the breast, a normal extension of breast glandular tissue that tapers into the underarm.
“Some women have axillary tail of the breast. This is probably that. It may produce milk if it has active mammary glands," she told Moneycontrol .
She also confirmed that humans can have supernumerary nipples along what is known as the “embryonic milk line,” extending from the armpit toward the chest. However, this line does not extend down to the thigh, as Jasmine recalled in her video.
According to experts, the axillary tail can feel like a lump or thickened area, particularly during hormonal changes such as pregnancy, breastfeeding or menstruation and may become tender or enlarged.
“Regular breast production is sufficient for me,” she said, noting that the extra tissue was painful and that she might consider surgically removing the tissue after she decides not to have more children.
Credit: Canva
Even as India is working to roll out a free Human papillomavirus (HPV) vaccination campaign to curb cervical cancer risk, a new global study today revealed that the shot offers sustained protection for up to 18 years.
HPV is one of the most common sexually transmitted infections, and many countries offer vaccination to protect girls against cervical cancer and other related cancers in later life.
The study from Sweden, published by The BMJ, based on 926,362 girls and women between 2006 and 2023, showed that girls vaccinated before age 17 had a substantially (79 percent) lower risk of cervical cancer.
"This study provides evidence of sustained protection against invasive cervical cancer throughout 18 years of follow-up, with no indication of waning protection," said corresponding author Shiqiang Wu, doctoral student at the Department of Medical Epidemiology and Biostatistics, Karolinska Institutet.
"These findings further support global strategies for eliminating cervical cancer as a public health problem by achieving high coverage of routine HPV vaccination," Wu added.
In the study, 40 percent of participants had received at least one dose of the quadrivalent HPV vaccine.
Of 930 cases identified of invasive cervical cancer, 97 were in vaccinated individuals, while 833 were among the unvaccinated.
Vaccination before age 17 offered higher protection -- 79 percent -- against cervical cancer compared with the unvaccinated group. The protection was sustained with 77 percent lower risk for over 15 years after vaccination, the researchers said.
On the other hand, women vaccinated at age 17 or older had a 37 percent lower risk of invasive cervical cancer compared with the unvaccinated group. Vaccination at an older age led to a 46 percent lower risk of cervical cancer -- about 10–12 years.
The results also show a population-level decline in cervical cancer cases over time.
Cervical cancer remains the second most common cancer among women in India, with nearly 80,000 new cases and over 42,000 deaths reported annually.
The new nationwide HPV vaccination program will strengthen women's health and eliminate the risks of preventable cervical cancers in the country.
Vaccination under the national program will be voluntary and free of cost.
The nationwide program, based on expert recommendations of the National Technical Advisory Group on Immunization (NTAGI), will target girls aged 14 years.
At 14, the HPV vaccine offers maximum preventive benefit, well before potential exposure to the virus.
The HPV vaccination will be conducted exclusively at designated government health facilities, including Ayushman Arogya Mandirs (Primary Health Centers), Community Health Centers, Sub-District and District Hospitals, and Government Medical Colleges.
© 2024 Bennett, Coleman & Company Limited