Can Damaged Sperm Lead To Pregnancy Complications?
Pregnancy is usually a time of happiness and hope, but it also brings in the unexpected. While there is much talk placed on the health of the expectant mother, the quality sperm coming from the father could dramatically change the outcome of pregnancy. The latest study suggests the risks of sperm DNA damage, even increasing the risks of complications preeclampsia and birth prematurity.
In a groundbreaking research study conducted by scientists from Lund University in Sweden, scientists discovered that DNA damage in sperm increases the risk almost up to double that of preeclampsia, this is a dangerous condition that may arise during pregnancies characterized by high blood pressure. In addition, DNA anomalies also increase the risk of premature births, and this further entails increased related adverse health outcomes for infants born through such conditions.
The next step would be to find out which group of men respond best to methods to prevent and treat sperm DNA damage, and to test these methods to prevent pregnancy complications," said Dr. Amelie Stenqvist, a lecturer at Lund University. According to this study, a significant message is put forward that paternal health assumes an important role in a successful pregnancy.
It focused its research on men, specifically whose sperm contained high levels of DNA fragmentation. For instance, some 20% to 30% of babies born via in vitro fertilization have fathers whose sperm contains damaged DNA. The DNA fragmentation index, an indicator to assess the percentage of DNA damage in sperm, indicated that when the percentage of sperm with a DFI above 30% was observed, they had almost no chance of resulting in natural conception. Even a DFI greater than 20% showed that the chances of getting pregnant are highly risky as the risk factor for pregnancy complications like preeclampsia is much high.
Uncommon Complications during Pregnancy
The most alarming complication during pregnancy is preeclampsia. It affects approximately 5% to 8% of pregnancies worldwide, which can cause fatal conditions for both the mother and the baby. The new findings now point out that sperm DNA damage may contribute to this condition, especially if it is due to assisted reproductive techniques such as IVF pregnancies. The research found that a DFI above 20% doubled the risk of preeclampsia from a mere 5% to almost 11% per.
Apart from causing preeclampsia, DNA fragmentation in sperm is also known to increase the risk for prematurity. Most premature babies experience respiratory, neurological, and developmental complications. Therefore, some degree of early intervention might be important for prospective parents.
Some of the rarer, though serious complications include placental abruption, which is the separation of the placenta from the uterine wall and intrauterine growth restriction, a condition by which the baby does not grow normally in the womb. These conditions though rare are potentially catastrophic both to the mother and the child. Results from this study may help in establishing the contribution of the father in such pregnancies.
Further study into sperm DNA damage is of urgent interest with regard to its consequences for pregnancy outcomes. According to Professor Aleksander Giwercman of Lund University in the field of Reproductive Medicine, "the analysis of DFI should be introduced as routine test in all fertility clinics.". "It could give answers to couples who are having difficulties with infertility, but our latest result also shows that DFI analysis can be a method to identify high-risk pregnancies, explained Giwercman.
For many, DNA fragmentation in sperm is often treatable. Common causes are oxidative stress, age, smoking, being obese, and infections. Addressing these elements will likely reduce DNA damage in sperm for men, raising the chances for a healthy pregnancy and baby.
Overall, the study importance should take into consideration paternal as well as maternal health towards reaching for a healthy pregnancy. Though DNA fragmentation in the sperm is supposed to increase the risk factors for complications in pregnancies, the advances into novel treatment approaches and tests are likely to alleviate complications in many families. Thus the findings of this study offer optimism and pave a pathway to more holistic fertility treatments in the future.
Credit: AI
Learning a second or even a third language may do more than expand your communication skills. According to a new study presented at the Federation of European Neuroscience Societies (FENS) Forum 2026 in Barcelona, learning a new language could also help keep your brain younger as you age.
The findings of the study say that people who speak multiple languages have brains that appear biologically younger than those who speak only one language. The research added to the growing evidence that multilingualism has a beneficial effect on healthy cognitive ageing.
To investigate how language affects the ageing brain, researchers analysed brain activity in adults living in Spain's multilingual Basque region.
They used magnetoencephalography (MEG), a non-invasive brain imaging technique that records the brain's electrical activity, along with artificial intelligence (AI) to ascertain each participant's brain age.
Rather than relying on a person's actual age, the AI model assessed how well different regions of the brain communicated with one another, a key marker that normally weakens with age.
Researchers first trained the AI using brain scans from 728 adults with varying language abilities before validating the findings in an independent group of 144 participants.
Read more: Normal Ageing or Alzheimer's? Doctors Explain Six Key Differences to Watch For
The results revealed an association between multilingualism and a younger-looking brain. Compared with people who spoke only one language, bilingual participants had brains that appeared around six years younger. Those who spoke three languages had brains that looked approximately seven years younger, while participants fluent in four languages had brains that appeared up to 13 years younger.
Researcher Lucia Amoruso, deputy scientific director at the Basque Center on Cognition, Brain and Language in San Sebastián, Spain, said, “In simple terms, people who spoke more languages tended to have brains that looked younger than expected for their chronological age.”
The researchers also found that language proficiency mattered. People who learned additional languages earlier in life and became more fluent showed even greater differences in brain age.
Scientists believe speaking multiple languages provides the brain with a constant mental workout. Regularly switching between languages requires attention, memory, problem-solving and cognitive control, all of which strengthen the neural networks involved in thinking and decision-making.
This exercise may help maintain stronger communication between brain regions, increasing the brain's resilience against age-related decline.
While the team considered factors like age, sex, and education, multilingual individuals may also be more likely to engage in other habits that are beneficial for the brain.
Although the findings are encouraging, the researchers say that the study does not prove that learning another language directly slows brain ageing or prevents dementia. Experts say further long-term studies are needed to determine whether multilingualism can reduce the risk of neurodegenerative diseases such as Alzheimer's disease.
Despite the need for more research, scientists say the findings offer another compelling reason to learn a new language. Whether through formal classes, language-learning apps or everyday conversations, developing language skills could provide meaningful mental stimulation throughout life.
Credit: AI generated image
Millions of people around the world undergo blood tests every year to measure LDL, commonly known as "bad" cholesterol. But researchers now suggest that this standard test may not always provide the most accurate picture of heart disease risk.
A new study from Northwestern Medicine found that a blood test measuring apolipoprotein B (ApoB) may be better than LDL cholesterol testing for identifying people who need more intensive treatment to reduce their risk of heart attacks and strokes.
The researchers also found that using ApoB to guide treatment decisions could prevent more cardiovascular events while remaining cost-effective for healthcare systems. The findings were published in the journal JAMA.
"We found that ApoB testing to intensify cholesterol-lowering medication would prevent more heart attacks and strokes than current practice, and that these health benefits were achieved at a cost that represents good value for US healthcare payers," said study lead author Ciaran Kohli-Lynch, Assistant Professor of Preventive Medicine in the Division of Epidemiology at Northwestern University Feinberg School of Medicine.
Also read: Confused By Your Cholesterol Report? Here's What LDL And ApoB Really Mean
Doctors have traditionally relied on LDL ("bad") cholesterol and non-HDL cholesterol levels to assess heart disease risk and decide when patients should begin or intensify cholesterol-lowering treatment. While these tests provide useful information, researchers say they do not tell the whole story.
The difference lies in what the two tests measure:
"Research strongly shows that apolipoprotein B (ApoB) is better at identifying who is at risk because it counts the total number of harmful particles in the blood," Kohli-Lynch said.
According to the researchers, the number of harmful particles may provide a more accurate measure of cardiovascular risk than LDL cholesterol levels alone.
Read More: US Cardiologist Explains Why 2026 AHA Cholesterol Guidelines Recommend Starting Young
In a post on X, Dr. Sudhir, Senior Consultant Neurologist at the Institute of Neurosciences, Apollo Hospitals, Hyderabad, explained that ApoB is a protein found on potentially harmful cholesterol-carrying particles such as LDL and VLDL (very low-density lipoprotein).
"Think of ApoB as a count of the particles capable of entering artery walls and causing plaque. One ApoB is equal to one potentially harmful particle," he said.
Dr. Sudhir explained that two people can have the same LDL cholesterol level but very different numbers of cholesterol-carrying particles. The person with more particles will usually have a higher ApoB level and, potentially, a greater risk of cardiovascular disease.
He added that ApoB often provides a more accurate assessment of heart disease risk than LDL cholesterol alone.
Despite growing evidence supporting ApoB, the test is still not widely used in routine clinical practice because it generally requires an additional blood test beyond the standard cholesterol panel, increasing both cost and inconvenience.
"Our study asked: Is it worth spending extra money to use ApoB instead of LDL to guide treatment intensification?" Kohli-Lynch said.
Dr. Sudhir suggested that ApoB testing should be considered for:
Earlier this year, the American Heart Association and 10 other medical organisations released updated guidelines recommending that many people begin cholesterol-lowering therapy at younger ages.
"This means it is increasingly important to accurately identify who would benefit most from intensive treatment," Kohli-Lynch said.
The updated guidelines also recommend measuring ApoB, particularly in people with high triglycerides, diabetes or in situations where LDL cholesterol levels may underestimate the number of harmful cholesterol-carrying particles.
Credit: AI generated image
Do you often forget where you kept your keys or glasses and worry that it could be a sign of Alzheimer's disease? While many people become more forgetful with age, doctors say that occasional memory lapses are a normal part of ageing. Alzheimer's disease, however, causes a different pattern of decline that affects memory, thinking and the ability to function in everyday life.
HealthandMe spoke to two neurologists who explained how to tell the difference between normal age-related forgetfulness and the warning signs of Alzheimer's disease.
"Many people worry when they start becoming more forgetful with age. While some changes in memory and thinking are a natural part of growing older, Alzheimer's disease causes a different pattern of decline that affects everyday life," said Dr. Rajneesh Kummar, Vice Chairman & Unit Head, Neurology, Max Super Speciality Hospital, Dwarka.
Dr. Praveen Gupta, Chairman, MAIINS, Marengo Asia Hospitals, Gurugram, added, "Alzheimer's is not a normal part of ageing. It's a neurodegenerative disease that affects memory, thinking and how you function each day. Recognising the difference can help people get medical evaluation and treatment sooner."
Also read: India Gets Its First Alzheimer’s Drug: Know All About Eli Lilly’s Lormalzi
The experts advised that persistent memory concerns should not be ignored. If symptoms become more noticeable or begin affecting day-to-day functioning, a medical assessment can help identify the cause and guide appropriate treatment and support.
They outlined six key differences that can help distinguish normal ageing from Alzheimer's disease.

According to the doctors, it is common to occasionally misplace items, forget a name or an appointment, and remember the information later.
However, people with Alzheimer's disease may repeatedly forget recent events, conversations, appointments or newly learned information and may not recall them even after reminders.
Normal ageing may mean taking longer to learn new technology or complete routine tasks.
In Alzheimer's disease, people may struggle to manage bills, prepare meals, follow directions, learn to use a new phone or remember instructions given only moments earlier.
Occasionally losing keys or glasses is considered a normal part of ageing, and most people can usually retrace their steps and find them.
By contrast, people with Alzheimer's disease may not remember putting an item down or even recall recently getting or buying it.
Older adults may occasionally lose track of the day or date but usually remember it shortly afterwards.
According to the doctors, Alzheimer's disease can cause confusion about time, dates and places. People may repeatedly ask the same questions or become disoriented, even in familiar surroundings.
Everyone experiences occasional "tip-of-the-tongue" moments.
With Alzheimer's disease, people may frequently lose their train of thought, repeat themselves, struggle to follow conversations or have difficulty finding the right words.
The doctors said one of the biggest differences is that normal ageing generally does not prevent a person from living independently.
Alzheimer's disease, however, gradually affects a person's ability to carry out everyday activities, adapt to changes in routine and maintain self-care without assistance.
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