Pregnancy is usually a time of happiness and hope, but it also brings in the unexpected. While there is much talk placed on the health of the expectant mother, the quality sperm coming from the father could dramatically change the outcome of pregnancy. The latest study suggests the risks of sperm DNA damage, even increasing the risks of complications preeclampsia and birth prematurity.

In a groundbreaking research study conducted by scientists from Lund University in Sweden, scientists discovered that DNA damage in sperm increases the risk almost up to double that of preeclampsia, this is a dangerous condition that may arise during pregnancies characterized by high blood pressure. In addition, DNA anomalies also increase the risk of premature births, and this further entails increased related adverse health outcomes for infants born through such conditions.

The next step would be to find out which group of men respond best to methods to prevent and treat sperm DNA damage, and to test these methods to prevent pregnancy complications," said Dr. Amelie Stenqvist, a lecturer at Lund University. According to this study, a significant message is put forward that paternal health assumes an important role in a successful pregnancy.

It focused its research on men, specifically whose sperm contained high levels of DNA fragmentation. For instance, some 20% to 30% of babies born via in vitro fertilization have fathers whose sperm contains damaged DNA. The DNA fragmentation index, an indicator to assess the percentage of DNA damage in sperm, indicated that when the percentage of sperm with a DFI above 30% was observed, they had almost no chance of resulting in natural conception. Even a DFI greater than 20% showed that the chances of getting pregnant are highly risky as the risk factor for pregnancy complications like preeclampsia is much high.

Uncommon Complications during Pregnancy

The most alarming complication during pregnancy is preeclampsia. It affects approximately 5% to 8% of pregnancies worldwide, which can cause fatal conditions for both the mother and the baby. The new findings now point out that sperm DNA damage may contribute to this condition, especially if it is due to assisted reproductive techniques such as IVF pregnancies. The research found that a DFI above 20% doubled the risk of preeclampsia from a mere 5% to almost 11% per.

Apart from causing preeclampsia, DNA fragmentation in sperm is also known to increase the risk for prematurity. Most premature babies experience respiratory, neurological, and developmental complications. Therefore, some degree of early intervention might be important for prospective parents.

Some of the rarer, though serious complications include placental abruption, which is the separation of the placenta from the uterine wall and intrauterine growth restriction, a condition by which the baby does not grow normally in the womb. These conditions though rare are potentially catastrophic both to the mother and the child. Results from this study may help in establishing the contribution of the father in such pregnancies.

Further study into sperm DNA damage is of urgent interest with regard to its consequences for pregnancy outcomes. According to Professor Aleksander Giwercman of Lund University in the field of Reproductive Medicine, "the analysis of DFI should be introduced as routine test in all fertility clinics.". "It could give answers to couples who are having difficulties with infertility, but our latest result also shows that DFI analysis can be a method to identify high-risk pregnancies, explained Giwercman.

For many, DNA fragmentation in sperm is often treatable. Common causes are oxidative stress, age, smoking, being obese, and infections. Addressing these elements will likely reduce DNA damage in sperm for men, raising the chances for a healthy pregnancy and baby.

Overall, the study importance should take into consideration paternal as well as maternal health towards reaching for a healthy pregnancy. Though DNA fragmentation in the sperm is supposed to increase the risk factors for complications in pregnancies, the advances into novel treatment approaches and tests are likely to alleviate complications in many families. Thus the findings of this study offer optimism and pave a pathway to more holistic fertility treatments in the future.

Feeling breathless after climbing several flights of stairs or a session of strenuous exercise is usually considered normal.

But breathlessness that appears suddenly, happens frequently, or occurs during routine activities should never be dismissed as tiredness or lack of fitness.

When Is Breathlessness Concerning?

Breathlessness, clinically known as dyspnoea, can occur due to many reasons. Asthma, allergies, respiratory infections, chronic lung disease, and heart problems are some of the common possibilities. Anxiety, anaemia and obesity could also be driving factors.

In some cases, persistent or unexplained breathing difficulty may also be linked to more serious conditions, including lung cancer. The important thing is to understand when breathlessness needs medical attention.

HealthandMe spoke to lung disease experts - Dr. Sachin Kumar, Director of Pulmonology & Critical Care Medicine, Sakra World Hospital, Bengaluru, Dr. Sanjeev Kumar, Director & Unit Head of GI & HPB Surgical Oncology & Clinical Administrator, Surgical Oncology, Max Super Specialty Hospital, Dwarka, Dr. Ruchi Singh, HOD & Senior Consultant, Radiation Oncology, Asian Institute of Medical Sciences, and Dr. Ashwin Mallya, Uro-Oncologist and Robotic Surgeon, Sir Ganga Ram Hospital.

Dr. Sanjeev Kumar explains that breathlessness that gets worse during routine activities are major red flags. He also says that other symptoms like chronic cough, coughing up blood, tiredness, and others should not be neglected.

He says, "Pay attention if breathlessness is accompanied by chest pain or pressure, dizziness, fainting, unusual sweating, bluish lips or fingertips, or a feeling that you cannot get enough air. A persistent cough, wheezing, recurring chest infections, coughing up blood, unexplained weight loss or prolonged fatigue along with breathlessness also deserves medical assessment. A cough that does not go away or changes in a long-standing smoker’s cough should not be overlooked. Although these symptoms can have several causes, they can occasionally be associated with lung cancer and need appropriate evaluation."

He also said that changes in usual breathing capacity is also a red flag. He said that if you previously walked comfortably for 20–30 minutes but now have to stop frequently because you are breathless, this change should not simply be attributed to age.

Also read: Lung Nodule on CT Scan? Doctors Explain When You Should Worry

Risks Of Delayed Evaluation & Treatment

Dr. Ruchi Singh points to a worrying trend. She said that the initial symptoms of lung cancer are usually dismissed as routine, which leads to delayed evaluation and treatment.

She says, "One of the most concerning things we are tracking is how late many patients present. Because symptoms like persistent cough or breathlessness are so easily mistaken for pollution-related irritation or a lingering infection, people delay getting scanned."

She explains that earlier detection through low-dose CT screening in high-risk groups remains the best tool for improving survival, and awareness needs to catch up with how the patient's profile itself is changing.

Also read: Can Fitness Hide Lung Cancer? Why Even Active People Shouldn't Ignore Symptoms

Importance Of A Multidisciplinary Approach

Talking about how lung cancer could metastasize, Dr Ashwin Mallya explains that along with early evaluation, it is essential to adopt a treatment strategy

Dr Mallya said, "Although primarily a thoracic malignancy, lung cancer frequently extends beyond the chest. Adrenal metastases are among its most common distant manifestations, while renal metastases, though less frequent, are well recognised."

He added, "These patterns underscore the importance of a multidisciplinary approach, often bringing urologists into the care of patients with advanced disease."

Also read: 'I Wish Every Patient Knew This Before Their Lung Cancer Diagnosis'- Lessons From An Oncologist

Lung Cancer Is No Longer A Smoker's Disease

Giving a real-life example of how lung cancer is no longer a smoker's disease, Dr Sachin Kumar said, "A 50-year-old lady went to the clinic seeking a second opinion after being treated for "asthma" for several weeks. She complained of occasional breathlessness and a persistent cough. Despite inhalers, her symptoms continued. A simple chest X-ray revealed something entirely different: a massive pleural effusion (fluid around the lung). Further evaluation confirmed the underlying cause: *lung cancer that had spread to the pleura (the lining surrounding the lungs).

He added, "This case is a reminder that not every cough or episode of breathlessness is asthma. When symptoms persist or do not respond as expected, they deserve a fresh look. Sadly, lung cancer is no longer a disease seen only in older male smokers. In our own practice, we now diagnose around 2–3 new cases of primary lung cancer every three months, and nearly 40% of these patients are either women or people who have never smoked."

Kidney stones are no longer a disease seen only in middle-aged adults. Across urban India, nephrologists are witnessing an increasing number of young professionals developing kidney stones. Sedentary lifestyles, inadequate water intake, unhealthy dietary habits, obesity, and rising temperatures are all contributing to this growing problem.

It is estimated that nearly one in every ten Indians will develop a kidney stone during their lifetime, and almost half of these patients may experience recurrence if preventive measures are not adopted.

Why Are Kidney Stones Becoming More Common?

Kidney stones form when minerals and salts in the urine become highly concentrated and crystallize inside the kidneys.

Several lifestyle factors increase this risk:

• Drinking too little water

• Excessive salt intake

• Frequent consumption of processed foods and sugary beverages

• High intake of animal protein

• Obesity and sedentary lifestyle

• Diabetes and hypertension

• Prolonged exposure to hot weather causing dehydration

• Busy work schedules, air-conditioned offices, frequent travel, and ignoring the urge to drink water have become common contributors in urban populations

Also read: Adult Kidney Transplant Recipients Who Took COVID-19 Drug Remdesivir At Lower Risk Of Transplant Failure

Warning Signs

The symptoms depend upon the size and location of the stone. Small stones may pass unnoticed, while larger stones can produce severe pain. Common symptoms include:

• Sudden severe pain in the back, side, or lower abdomen

• Pain radiating towards the groin

• Burning during urination

• Blood in urine

• Increased frequency or urgency of urination

• Nausea and vomiting

• Fever with chills, especially if infection develops

• Persistent pain, fever, or difficulty passing urine should never be ignored, as these may indicate obstruction or infection requiring urgent medical attention

Also read: Why Dialysis Patients Should Check Their Fistula Every Day

Can Kidney Stones Be Prevented?

The answer is yes. Most kidney stones can be prevented through simple lifestyle modifications. The most important preventive measure is adequate hydration. Adults should drink enough fluids to produce at least 2–2.5 litres of urine daily, which generally requires about 2.5–3 litres of water per day, depending on climate and physical activity.

Other preventive measures include:

• Reduce salt intake

• Limit processed and packaged foods

• Moderate consumption of red meat

• Avoid excessive sugary drinks

• Maintain a healthy body weight

• Exercise regularly

• Control diabetes and high blood pressure

Contrary to popular belief, dietary calcium should not be avoided unless specifically advised by a doctor. In fact, normal calcium intake helps reduce oxalate absorption and lowers the risk of stone formation.

Modern Treatment Has Changed the Outlook

Fortunately, advances in technology have made kidney stone treatment highly effective and minimally invasive.

Small stones often pass with increased fluid intake, pain relief, and medications that relax the urinary tract. However, larger or obstructing stones require specialist treatment.

Current treatment options include:

• Extracorporeal Shock Wave Lithotripsy (ESWL): Non-invasive shock waves break stones into smaller fragments

• Ureteroscopy (URS): A thin endoscope is passed through the urinary tract to remove or fragment stones

• Retrograde Intrarenal Surgery (RIRS): Flexible laser technology allows treatment of stones inside the kidney without any external incision

• Percutaneous Nephrolithotomy (PCNL): Recommended for large or complex kidney stones through a small skin incision

• Compared with conventional open surgery, these procedures offer higher success rates, less pain, shorter hospital stays, and faster recovery

The Take-Home Message

Kidney stones are becoming increasingly common but are largely preventable. Adequate hydration, healthy dietary habits, regular exercise, and timely medical evaluation can significantly reduce the risk. Those who have already developed one stone should undergo metabolic evaluation and follow preventive advice, as recurrence is common.

Early diagnosis and timely treatment not only relieve pain but also protect kidney function and improve long-term health.

Many people assume that if they exercise regularly, eat healthy, and stay active, they are naturally protected from serious illnesses like lung cancer. It is a comforting belief but unfortunately, it is not entirely true. While a healthy lifestyle lowers the risk of many diseases and improves overall well-being, it does not make anyone completely immune to lung cancer.

This misconception often leads to another problem: delayed diagnosis. When someone who has never smoked or is physically fit develops a persistent cough, unusual tiredness, or breathlessness, they may dismiss these symptoms as a lingering cold, seasonal allergies, or simply overexertion after a workout. Family members may do the same, assuming that someone who looks healthy couldn't possibly have a serious lung condition. As a result, valuable time may be lost before medical help is sought.

Being Fit Doesn't Eliminate Lung Cancer Risk

Some forms of lung cancer, especially adenocarcinoma, develop in the outer parts of the lungs, where they may grow silently for months before causing noticeable symptoms.

Also read: The 'Safer Than Smoking' Myth? Doctors Warn Vaping May Carry Its Own Lung Cancer Risks

Warning Signs That Should Never Be Ignored

One of the challenges is that active individuals often have better lung capacity and stamina, allowing their bodies to compensate for early changes. This can make the warning signs subtler in the beginning.

A persistent cough, breathlessness during activities that once felt easy, unexplained fatigue, chest discomfort, hoarseness of voice, recurrent chest infections, coughing up blood, or unexplained weight loss should never be ignored, especially if these symptoms last for more than two to three weeks.

Also read: Bryan Johnson's New 2.6M Women's Health Project Centers on Girlfriend's Menstrual Blood

Early Detection Can Save Lives

The encouraging news is that early detection can make a significant difference. Recognizing persistent symptoms and seeking medical evaluation promptly can lead to earlier diagnosis, when treatment is often more effective. Depending on an individual's symptoms and risk factors, a doctor may recommend investigations such as a chest X-ray or CT scan.

Staying physically active remains one of the best decisions a person can make for their health. Exercise strengthens the heart, improves lung function, and reduces the risk of several chronic diseases.

But fitness should never create a false sense of security. The body has its own way of asking for attention, and listening to those signals no matter how healthy a person feels can sometimes be the most important step toward protecting long-term health.

By Dr. Jayesh Prajapati, Senior Consultant Surgical Oncology, Sterling Hospital, Ahmedabad