Can Damaged Sperm Lead To Pregnancy Complications?
Pregnancy is usually a time of happiness and hope, but it also brings in the unexpected. While there is much talk placed on the health of the expectant mother, the quality sperm coming from the father could dramatically change the outcome of pregnancy. The latest study suggests the risks of sperm DNA damage, even increasing the risks of complications preeclampsia and birth prematurity.
In a groundbreaking research study conducted by scientists from Lund University in Sweden, scientists discovered that DNA damage in sperm increases the risk almost up to double that of preeclampsia, this is a dangerous condition that may arise during pregnancies characterized by high blood pressure. In addition, DNA anomalies also increase the risk of premature births, and this further entails increased related adverse health outcomes for infants born through such conditions.
The next step would be to find out which group of men respond best to methods to prevent and treat sperm DNA damage, and to test these methods to prevent pregnancy complications," said Dr. Amelie Stenqvist, a lecturer at Lund University. According to this study, a significant message is put forward that paternal health assumes an important role in a successful pregnancy.
It focused its research on men, specifically whose sperm contained high levels of DNA fragmentation. For instance, some 20% to 30% of babies born via in vitro fertilization have fathers whose sperm contains damaged DNA. The DNA fragmentation index, an indicator to assess the percentage of DNA damage in sperm, indicated that when the percentage of sperm with a DFI above 30% was observed, they had almost no chance of resulting in natural conception. Even a DFI greater than 20% showed that the chances of getting pregnant are highly risky as the risk factor for pregnancy complications like preeclampsia is much high.
Uncommon Complications during Pregnancy
The most alarming complication during pregnancy is preeclampsia. It affects approximately 5% to 8% of pregnancies worldwide, which can cause fatal conditions for both the mother and the baby. The new findings now point out that sperm DNA damage may contribute to this condition, especially if it is due to assisted reproductive techniques such as IVF pregnancies. The research found that a DFI above 20% doubled the risk of preeclampsia from a mere 5% to almost 11% per.
Apart from causing preeclampsia, DNA fragmentation in sperm is also known to increase the risk for prematurity. Most premature babies experience respiratory, neurological, and developmental complications. Therefore, some degree of early intervention might be important for prospective parents.
Some of the rarer, though serious complications include placental abruption, which is the separation of the placenta from the uterine wall and intrauterine growth restriction, a condition by which the baby does not grow normally in the womb. These conditions though rare are potentially catastrophic both to the mother and the child. Results from this study may help in establishing the contribution of the father in such pregnancies.
Further study into sperm DNA damage is of urgent interest with regard to its consequences for pregnancy outcomes. According to Professor Aleksander Giwercman of Lund University in the field of Reproductive Medicine, "the analysis of DFI should be introduced as routine test in all fertility clinics.". "It could give answers to couples who are having difficulties with infertility, but our latest result also shows that DFI analysis can be a method to identify high-risk pregnancies, explained Giwercman.
For many, DNA fragmentation in sperm is often treatable. Common causes are oxidative stress, age, smoking, being obese, and infections. Addressing these elements will likely reduce DNA damage in sperm for men, raising the chances for a healthy pregnancy and baby.
Overall, the study importance should take into consideration paternal as well as maternal health towards reaching for a healthy pregnancy. Though DNA fragmentation in the sperm is supposed to increase the risk factors for complications in pregnancies, the advances into novel treatment approaches and tests are likely to alleviate complications in many families. Thus the findings of this study offer optimism and pave a pathway to more holistic fertility treatments in the future.
Credit: X.com
When John Cena started noticing blurry vision, he assumed it was simply part of getting older. But the worsening eyesight was also accompanied by redness, itchiness and crusting around his eyes.
“I had a lot of redness and itchiness, and every once in a while, waking up with eye crusties and stuff. At the same time, given my age — I'm 49 now — my vision was going a little bit, so I just figured it was par for the course. But because my vision was going, I needed to see if I needed glasses or prescriptions.”
Until then, Cena had delayed getting his eyes checked. He believed that the symptoms were caused by bright lights, excessive screen time or ageing.
However, an eye examination gave him a surprise. Cena learned that his symptoms were caused by Demodex blepharitis, a condition he says he had never heard of.
“Diagnosed with Demodex blepharitis, which I didn't even know existed.”
Also read: Study Decodes Why COVID Survivors Continue To Suffer Vision Problems
Demodex mites are tiny, eight-legged organisms that live naturally on human skin, particularly around hair follicles. Measuring just 0.15 to 0.4 millimeters, they are invisible to the naked eye but are present on the skin of almost every adult.
These microscopic mites feed on sebum (the skin's natural oil) and dead skin cells, helping remove accumulated debris under normal conditions.
Demodex mites are most active at night. They emerge from hair follicles after sunset because ultraviolet (UV) light is harmful to them. While people sleep, the mites feed, crawl and reproduce on the skin's surface.
They are also believed to be stimulated by melatonin, the hormone that helps regulate sleep, creating a unique relationship between humans and these naturally occurring organisms.
Although harmless in small numbers, Demodex mites can cause problems if they multiply excessively—a condition known as demodicosis.
According to Dr. Richard Locksley, professor of medicine at the University of California, San Francisco, an overgrowth of Demodex mites can contribute to:
Read More: Wegovy More Likely To Cause Rare Blindness Than Ozempic And Other Similar Drugs, Recent Study Finds
People with weakened immune systems are particularly vulnerable because their bodies may be less able to control mite populations. In addition, inadequate sleep may increase oil production, providing more nourishment for the mites.
For most healthy people, Demodex mites are a normal part of the skin microbiome and are not considered harmful. Problems generally arise only when their numbers increase significantly.
To help reduce the risk of overgrowth:
Credit: iStock
A stroke can happen suddenly and without warning, making every minute count. The first 60 minutes after the onset of stroke symptoms are crucial because timely medical treatment can help reduce brain damage and improve recovery.
A stroke happens when the blood flow to an area of the brain is cut off due to either the blockage of a blood vessel supplying that area or the bursting of the said blood vessel. Without adequate blood flow, brain cells are deprived of oxygen and nutrients and begin to be damaged within minutes.
The first hour after a stroke is focused on rapid assessment and treatment. Once the patient reaches the hospital, doctors evaluate the symptoms, determine when they started, and perform an urgent brain scan, usually a CT scan, to identify the type of stroke.
This step is important because treatment depends on whether the stroke is caused by a blocked artery (ischemic stroke) or bleeding in the brain (hemorrhagic stroke). For eligible patients with an ischemic stroke, clot-dissolving medication or a procedure to remove the clot may be considered.
Although treatment windows may extend beyond the first hour for some patients, reaching the hospital as early as possible offers the greatest chance of saving brain tissue. In most patients, clot-dissolving medication is given within 4.5 hours of symptom onset, while selected patients may be eligible for treatment up to 9 hours. Mechanical clot removal is generally performed within 6 hours, although carefully selected patients may benefit from the procedure up to 24 hours after symptoms begin. However, earlier treatment is associated with better protection of brain tissue and improved outcomes.
Recognizing stroke symptoms early can help save valuable time. The BEFAST acronym is a simple way to remember the common warning signs:
B – Sudden loss of balance or coordination
E – Sudden vision loss or changes in one or both eyes
F – Face drooping
A – Arm weakness
S – Speech difficulty
T – Time to call emergency medical services
Other symptoms may include sudden loss of vision, dizziness, difficulty walking, numbness on one side of the body, confusion, or a sudden, severe headache.
During a stroke, brain cells continue to be damaged as blood flow remains interrupted. Delays in reaching the hospital can limit treatment options and increase the risk of long-term disability. Seeking medical care as early as possible gives doctors the best chance to provide appropriate treatment.
If you notice stroke symptoms in yourself or someone else, do not ignore them or wait for them to improve. Call emergency medical services immediately and note the time the symptoms first appeared, as this information helps doctors decide the most suitable treatment.
The golden hour is a critical window during which timely action can significantly improve outcomes. Recognizing the signs of stroke and seeking immediate medical care can make a meaningful difference in recovery.
Credit: AI
Massive wildfires have ravaged several parts of Canada and other regions of the world, filling the air with hazardous smoke. This has triggered health warnings far beyond the fire zones.
While most people experience immediate breathing problems during and after wildfires, experts say that some health effects can persist long after the skies clear.
Wildfire smoke is composed of harmful gases and microscopic particles known as PM2.5. These tiny particles are small enough to travel into our lungs and enter the bloodstream, where they can trigger inflammation throughout the body.
Unlike typical air pollution, wildfire smoke also contains toxic substances released from burning homes, plastics, furniture, vehicles, electronics, and industrial materials, making prolonged exposure particularly harmful.
Also read: Delhi's Poor AQI, Monsoon Conditions Put Children's Lungs at Risk: Ways to Keep Kids Safe
Prolonged exposure to wildfire smoke can have long-term effects on the respiratory system. Possible health effects may include:
Children, older adults, and people with existing lung conditions face the highest risk because their lung function is already compromised.
Also read: Phones, Pollution, AI: What Is Driving Cognitive Decline In Humans?
The tiny particles in wildfire smoke don't just stay confined to the lungs. Once they enter the bloodstream, they can affect the cardiovascular system. In the long run, research says wildfire smoke exposure can lead to:
With frequent incidences of wildfires, scientists are looking into how wildfire smoke affects the brain. Emerging evidence suggests smoke exposure may contribute to:
Wildfires can affect mental health in more than one way. Besides the stress of evacuation and property loss, smoke exposure itself may contribute to mental health problems directly. One is at the risk of the following mental health issues after exposure:
Communities repeatedly exposed to wildfire events may experience prolonged psychological distress that could often go undetected.
Growing evidence suggests that long-term exposure to wildfire smoke may increase the risk of several cancers. Studies have reported possible associations with lung cancer, breast cancer, colorectal cancer, bladder cancer, and certain blood cancers
Although researchers say more studies are needed to establish a direct cause-and-effect relationship, the findings highlight the importance of limiting repeated smoke exposure.
Also read: How Air Pollution Puts Heart Patients At Risk - What You Can Do About It
Pregnant women are among the groups considered most vulnerable to wildfire smoke. Research suggests exposure during pregnancy may increase the risk of preterm birth, low birth weight and other pregnancy complications.
Healthcare providers recommend minimizing outdoor exposure whenever air quality deteriorates.
Even after visible smoke disappears, harmful particles may remain in the air. Experts recommend:
© 2024 Bennett, Coleman & Company Limited