Can Damaged Sperm Lead To Pregnancy Complications?
Pregnancy is usually a time of happiness and hope, but it also brings in the unexpected. While there is much talk placed on the health of the expectant mother, the quality sperm coming from the father could dramatically change the outcome of pregnancy. The latest study suggests the risks of sperm DNA damage, even increasing the risks of complications preeclampsia and birth prematurity.
In a groundbreaking research study conducted by scientists from Lund University in Sweden, scientists discovered that DNA damage in sperm increases the risk almost up to double that of preeclampsia, this is a dangerous condition that may arise during pregnancies characterized by high blood pressure. In addition, DNA anomalies also increase the risk of premature births, and this further entails increased related adverse health outcomes for infants born through such conditions.
The next step would be to find out which group of men respond best to methods to prevent and treat sperm DNA damage, and to test these methods to prevent pregnancy complications," said Dr. Amelie Stenqvist, a lecturer at Lund University. According to this study, a significant message is put forward that paternal health assumes an important role in a successful pregnancy.
It focused its research on men, specifically whose sperm contained high levels of DNA fragmentation. For instance, some 20% to 30% of babies born via in vitro fertilization have fathers whose sperm contains damaged DNA. The DNA fragmentation index, an indicator to assess the percentage of DNA damage in sperm, indicated that when the percentage of sperm with a DFI above 30% was observed, they had almost no chance of resulting in natural conception. Even a DFI greater than 20% showed that the chances of getting pregnant are highly risky as the risk factor for pregnancy complications like preeclampsia is much high.
Uncommon Complications during Pregnancy
The most alarming complication during pregnancy is preeclampsia. It affects approximately 5% to 8% of pregnancies worldwide, which can cause fatal conditions for both the mother and the baby. The new findings now point out that sperm DNA damage may contribute to this condition, especially if it is due to assisted reproductive techniques such as IVF pregnancies. The research found that a DFI above 20% doubled the risk of preeclampsia from a mere 5% to almost 11% per.
Apart from causing preeclampsia, DNA fragmentation in sperm is also known to increase the risk for prematurity. Most premature babies experience respiratory, neurological, and developmental complications. Therefore, some degree of early intervention might be important for prospective parents.
Some of the rarer, though serious complications include placental abruption, which is the separation of the placenta from the uterine wall and intrauterine growth restriction, a condition by which the baby does not grow normally in the womb. These conditions though rare are potentially catastrophic both to the mother and the child. Results from this study may help in establishing the contribution of the father in such pregnancies.
Further study into sperm DNA damage is of urgent interest with regard to its consequences for pregnancy outcomes. According to Professor Aleksander Giwercman of Lund University in the field of Reproductive Medicine, "the analysis of DFI should be introduced as routine test in all fertility clinics.". "It could give answers to couples who are having difficulties with infertility, but our latest result also shows that DFI analysis can be a method to identify high-risk pregnancies, explained Giwercman.
For many, DNA fragmentation in sperm is often treatable. Common causes are oxidative stress, age, smoking, being obese, and infections. Addressing these elements will likely reduce DNA damage in sperm for men, raising the chances for a healthy pregnancy and baby.
Overall, the study importance should take into consideration paternal as well as maternal health towards reaching for a healthy pregnancy. Though DNA fragmentation in the sperm is supposed to increase the risk factors for complications in pregnancies, the advances into novel treatment approaches and tests are likely to alleviate complications in many families. Thus the findings of this study offer optimism and pave a pathway to more holistic fertility treatments in the future.
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US journalist Norah O’Donnell recently spoke about the importance of early skin cancer detection a decade after being diagnosed with melanoma, the most dangerous form of skin cancer.
She said her experience changed her outlook towards sun protection. She also shared advice related to skin cancer from her dermatologist, Dr Elizabeth Hale.
According to CBS News, O’Donnell recalled that it was during a routine dermatology appointment when Hale noticed two concerning spots on her back.
A biopsy confirmed melanoma, but the cancer was detected early and removed before it could spread.
O’Donnell said she now seeks shade wherever she can find, wears UV-protective clothing and regularly reapplies broad-spectrum sunscreen when spending time outdoors. She also reflected on her past exposure to sunburns and tanning salons.
Melanoma develops in the cells that produce melanin, the pigment responsible for skin colour. Although it accounts for a smaller proportion of skin cancer cases, it is responsible for an alarming share of skin cancer deaths.
Hale emphasised that early detection can make a considerable difference. “Even though it only accounts for 5% of new cases of skin cancer, it’s responsible for more than 75% of skin cancer-related deaths,” she said.
She also spoke about the importance of getting suspicious spots examined rather than waiting for them to become more noticeable and serious.
“There have been major advances in melanoma treatment, but it’s still really best to get your skin checked because when melanoma is caught early it has greater than a 99% five-year survival. But once it spreads, that survival rate goes down precipitously,” Hale said.
Speaking about skin cancer risks related to tanning beds and sunburns, Hale said melanoma cases have been increasing among women in their 20s and 30s.
“It is directly related to exposure to tanning beds and to sunburns,” she said.
According to the Skin Cancer Foundation, using tanning beds before 35 could increase melanoma risk by 75%.
Hale also warned against the growing trend of deliberately seeking a tan through prolonged, unprotected sun exposure.
“There really is no such thing as … a safe, healthy tan,” she said.
A tan is not simply a cosmetic appeal. As Hale explained, it denotes “DNA damage” that may contribute to cancer later in life.
Hale recommends regular skin examinations to nab suspicious skin changes early. She advises people to discuss their individual cancer screening needs with a dermatologist, especially if they have a family history of skin cancer.
Sun protection is another essential part of prevention. Hale recommends using a broad-spectrum sunscreen with SPF 30 or higher and reapplying it every two hours when spending extended periods outdoors.
Her advice on choosing sunscreen is straightforward: “the best sunscreen is the one you’ll actually use”.
As per the Johns Hopkins Medicine, wearing sunscreen is the easiest and the best ways to protect your skin's appearance and health at any age. It recommends to use it regularly to prevent sunburn, skin cancer, and premature aging.
While everyone needs sun exposure to produce vitamin D, unprotected exposure to the sun's UV rays can cause damage to the eyes, skin, and the immune system.
To protect, apply 1 ounce of sunscreen throughout your body. To protect your face and neck, you will need about half a teaspoon of sunscreen.
Experts also believe that as long as the sunscreen is at least SPF 30 and is water-resistant, it does not matter what order you apply your skin care products. While some people find it is easiest to work with bare skin, some do it at the end.
Protective clothing and seeking shade can provide additional protection, especially during prolonged outdoor activities.
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Arthritis is sometimes treated like a normal part of getting older. Yet it can show up in many age groups. It can also limit how freely someone moves. That can affect daily independence and overall comfort.
Some people think arthritis care always means an operation, like joint replacement. In reality, the path to care is wider. What happens next depends on symptoms, which joint is affected, a person’s age, how active they are, and their general health.
Where the disease is in its early stages or is perceived to be mild, treatment will begin in a very low-key manner. This will involve physiotherapy and exercise. Where necessary, losing excess body weight can be beneficial. Minor changes in daily activities will decrease stress. Doctors will prescribe medication depending on the situation. Here, the main objective is to alleviate symptoms and maintain function. It will not be the initial step and will only be considered where appropriate.
In case arthritis is severe, pain and stiffness will persist for a long period of time. Performing simple activities becomes difficult. Even walking will become challenging. Sleep may also be affected. When this happens, it helps to check again. Doctors can use exam findings and imaging to see how much the joint has changed. They can also review whether non-surgical care is working as expected.
Good arthritis care is about choosing the right path for the right person. Timing matters too. It begins with a close look at symptoms and a clear diagnosis. Sometimes it also means getting scans when they are needed. After that, the plan should rely on what the best research shows.
Treatment should be set up with rehab in mind. The aim is to fit the person, not just the label on the chart. One person may do well with physical therapy and simple habit shifts. Another person may need a procedure, mainly when a joint is badly worn.
The main goal is easier daily comfort and better movement. Just as important, it should help someone keep their independence. It is also not only about chasing the newest option.
People should not wait until pain makes normal life hard. When they seek help early, it can be easier to see what is driving the joint pain. It can also help show how far the arthritis has gone. With that in hand, a care plan can be built with more clarity.
When care starts early and matches the person, many can stay active longer. They may also better protect joint function and keep it working well for more time.
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As pollution levels rise in October, doctors warn that exposure to particulate matter can affect lung and heart health, aggravate existing respiratory conditions, and cause symptoms even in otherwise healthy individuals, particularly as winter approaches.
PM2.5 and PM10 can irritate the respiratory tract, while fine particles such as PM2.5 can penetrate deep into the lungs, with some entering the bloodstream.
Delhi woke up to poor air quality on Thursday, with the Commission for Air Quality Management’s (CAQM) AQI dashboard recording an Air Quality Index (AQI) of 226 across Delhi-NCR at 7 am.
As per the CAQM’s dashboard, some areas of the national capital recorded very poor air quality, with an average AQI of 307.
The Commission for Air Quality Management (CAQM) on Wednesday imposed Stage I of the Graded Response Action Plan (GRAP) across Delhi-NCR after the capital's air quality slipped into the 'poor' category.
According to the Air Quality Early Warning System, Delhi's air quality is likely to remain in the 'poor' category until October 23. The forecast for the following six days also indicates that pollution levels are likely to remain in the same category.
Also read: Delhi Air Pollution Is Back: What Days Of Poor AQI Can Do to Your Lungs
Dr. Amit Kumar Mandal, Senior Director - Pulmonology, Paras Health Panchkula, told HealthandMe that air pollution can cause inflammation in the airways and worsen asthma, chronic obstructive pulmonary disease (COPD) and other respiratory conditions. It can also increase the risk of cardiovascular complications.
The effects may not always be immediately noticeable. People may experience persistent coughing, throat irritation, wheezing or breathlessness. Repeated exposure over time can contribute to more serious health problems, even in people without pre-existing conditions.
Dr. A.S. Sandhya, Consultant, Pulmonary & Sleep Medicine, Kailash Hospital & Neuro Institute, told HealthandMe that October can mark the beginning of a prolonged period of poor air quality in Delhi-NCR.
When pollution combines with changing weather conditions, people with asthma, bronchitis and COPD may experience more frequent symptoms. However, healthy individuals can also develop eye irritation, coughing, throat discomfort and reduced exercise tolerance after exposure to polluted air.
Read More: Can Delhi’s Air Pollution Increase GI Cancer Risk? Doctors Report Patients As Young As 15
Doctors recommend monitoring daily AQI levels and limiting exposure when air quality is poor.
Dr. Mandal advises reducing prolonged outdoor activity and avoiding exercise near busy roads during high-pollution periods. Children, older adults, pregnant women and people with respiratory or heart conditions should take extra precautions.
Dr. Sandhya recommends limiting strenuous outdoor exercise when pollution levels are high and using a well-fitted N95 mask when outdoor exposure cannot be avoided.
Indoor air quality also matters, particularly for children and older adults who spend extended periods at home. Air purifiers with suitable filtration may help reduce indoor particulate matter, although they do not eliminate all pollutants.
People should not ignore persistent coughing, wheezing or unusual breathlessness. Those experiencing persistent breathing difficulties, chest discomfort or worsening respiratory symptoms should consult a doctor.
People with existing medical conditions should follow their treatment plans and seek medical advice if their symptoms worsen.
Taking preventive measures now, rather than waiting for pollution to peak in winter, can help reduce exposure and the risk of avoidable health complications in the months ahead.
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