Can Damaged Sperm Lead To Pregnancy Complications?
Pregnancy is usually a time of happiness and hope, but it also brings in the unexpected. While there is much talk placed on the health of the expectant mother, the quality sperm coming from the father could dramatically change the outcome of pregnancy. The latest study suggests the risks of sperm DNA damage, even increasing the risks of complications preeclampsia and birth prematurity.
In a groundbreaking research study conducted by scientists from Lund University in Sweden, scientists discovered that DNA damage in sperm increases the risk almost up to double that of preeclampsia, this is a dangerous condition that may arise during pregnancies characterized by high blood pressure. In addition, DNA anomalies also increase the risk of premature births, and this further entails increased related adverse health outcomes for infants born through such conditions.
The next step would be to find out which group of men respond best to methods to prevent and treat sperm DNA damage, and to test these methods to prevent pregnancy complications," said Dr. Amelie Stenqvist, a lecturer at Lund University. According to this study, a significant message is put forward that paternal health assumes an important role in a successful pregnancy.
It focused its research on men, specifically whose sperm contained high levels of DNA fragmentation. For instance, some 20% to 30% of babies born via in vitro fertilization have fathers whose sperm contains damaged DNA. The DNA fragmentation index, an indicator to assess the percentage of DNA damage in sperm, indicated that when the percentage of sperm with a DFI above 30% was observed, they had almost no chance of resulting in natural conception. Even a DFI greater than 20% showed that the chances of getting pregnant are highly risky as the risk factor for pregnancy complications like preeclampsia is much high.
Uncommon Complications during Pregnancy
The most alarming complication during pregnancy is preeclampsia. It affects approximately 5% to 8% of pregnancies worldwide, which can cause fatal conditions for both the mother and the baby. The new findings now point out that sperm DNA damage may contribute to this condition, especially if it is due to assisted reproductive techniques such as IVF pregnancies. The research found that a DFI above 20% doubled the risk of preeclampsia from a mere 5% to almost 11% per.
Apart from causing preeclampsia, DNA fragmentation in sperm is also known to increase the risk for prematurity. Most premature babies experience respiratory, neurological, and developmental complications. Therefore, some degree of early intervention might be important for prospective parents.
Some of the rarer, though serious complications include placental abruption, which is the separation of the placenta from the uterine wall and intrauterine growth restriction, a condition by which the baby does not grow normally in the womb. These conditions though rare are potentially catastrophic both to the mother and the child. Results from this study may help in establishing the contribution of the father in such pregnancies.
Further study into sperm DNA damage is of urgent interest with regard to its consequences for pregnancy outcomes. According to Professor Aleksander Giwercman of Lund University in the field of Reproductive Medicine, "the analysis of DFI should be introduced as routine test in all fertility clinics.". "It could give answers to couples who are having difficulties with infertility, but our latest result also shows that DFI analysis can be a method to identify high-risk pregnancies, explained Giwercman.
For many, DNA fragmentation in sperm is often treatable. Common causes are oxidative stress, age, smoking, being obese, and infections. Addressing these elements will likely reduce DNA damage in sperm for men, raising the chances for a healthy pregnancy and baby.
Overall, the study importance should take into consideration paternal as well as maternal health towards reaching for a healthy pregnancy. Though DNA fragmentation in the sperm is supposed to increase the risk factors for complications in pregnancies, the advances into novel treatment approaches and tests are likely to alleviate complications in many families. Thus the findings of this study offer optimism and pave a pathway to more holistic fertility treatments in the future.
Credits: Canva
The last thing anyone hopes to unwrap this Christmas is a heavy dose of flu. Yet as hospital admissions linked to the virus climb to levels not seen since 2010, this winter’s flu surge has pushed the NHS into what officials are calling a “worst-case scenario.”
Infections have jumped by over 50 per cent in just one week, and health leaders say there is still no clear peak. On average, 2,660 people a day were occupying hospital beds with flu last week, the highest figure ever recorded for this point in the season. Data from the UK Health Security Agency show the highest infection rates among children aged five to 14, followed closely by young people between 15 and 24. A number of schools have temporarily closed to curb outbreaks, while NHS leaders have advised people to consider wearing masks at work or on public transport, echoing guidance seen during the Covid years.
The strain driving the current spike has picked up the nickname “super flu” because it is believed to be a mutated form of influenza A (H3N2), known as “subclade K.”
Influenza H3N2 does not circulate as often as some other flu strains. Dr Simon Clarke, associate professor of cellular microbiology at the University of Reading, explains that the letters “H” and “N” refer to two proteins found on the virus surface, haemagglutinin and neuraminidase. “The numbers simply tell us which versions of those proteins are present,” says Dr Clarke. “It’s a way of grouping strains. This year, H3N2 happens to be the one in the lead.”
“H3 subtypes are relatively uncommon,” he adds. “That means fewer people have built up immunity. There is also evidence they spread more easily and mutate faster, which makes them harder for vaccines to keep up with.
“What we are seeing now is the outcome of that: cases rising sharply earlier than usual, with numbers likely to climb further as winter goes on.”
Broadly speaking, flu falls into three main groups, A, B and C, according to Professor Ed Hutchinson from the Glasgow Centre for Virus Research. “Types A and B are the ones that make people seriously ill each winter. Influenza C circulates too, but it rarely causes severe disease. They are related, but not closely enough that immunity to one protects against the others,” he explains.
The concern is not that the virus has suddenly become far more deadly. Many people will catch it and recover without major problems. “The issue is scale,” Hutchinson says, as reported by The Telegraph. “When a virus spreads widely, even a small proportion of severe cases quickly adds up. That is what puts pressure on individuals and on the NHS.”
Last week, around 1,700 flu patients were in hospital, a 63 per cent increase on the previous week and more than 50 per cent higher than the same period last year. This rise is partly linked to a particularly aggressive subtype of the circulating H3N2 virus. “This strain is appearing earlier and spreading faster than we would expect, and immunity levels in the population are lower than usual for this stage of the season,” says Dr Aslam.
Recent figures suggest the flu vaccine cuts the risk of hospital admission by roughly 30 to 40 per cent in older adults. That protection rate is lower than for some other vaccines, but it is in line with flu vaccine performance in past years. For that reason, advice has not changed. Vaccination remains the single most effective step people can take to protect themselves and to ease pressure on the NHS.
This season’s vaccines are still doing a solid job of preventing severe illness. Vaccinated children are about 70 to 75 per cent less likely to need a hospital visit or admission for flu. Among adults, the reduction is closer to 30 to 40 per cent.
One reason for this gap is the type of vaccine used. Children receive a nasal spray, while adults are given an injection. Research shows the nasal spray works particularly well in children but is less effective in adults, which is why different recommendations exist. So the comparison reflects not just age, but also different vaccines.
Another factor is prior immunity. Adults have encountered many flu viruses over their lifetime, so the added benefit of each new vaccine dose may be smaller than it is for a child. Even so, that extra protection still matters and can make a real difference.
Credits: Canva
A medical expert has revealed that you might be able to tell which winter illness you’re dealing with just by the type of cough you have. According to Dr. Rupa Parmar, a GP and medical director at Midland Health, coughing can present differently depending on whether you have a cold, flu, or COVID-19. During the winter months, certain infections become more common. Viruses spread more easily in cold weather, and spending more time indoors with others makes transmission more likely.
Still, it can be tricky to identify exactly what’s wrong because symptoms often overlap. Dr. Parmar advises: “There are some key differences between a cold, Covid, and flu that make it easier to tell them apart. But if you’re unsure, always check with your doctor. It’s better to be safe when it comes to your health.”
Dr. Parmar explained: “A cold usually causes a mild cough, while a flu cough is typically dry.” According to the NHS, cold symptoms develop gradually over two to three days. In contrast, flu symptoms “come on very quickly,” with a dry cough being a key sign.
Covid can also cause a dry cough, but it is usually persistent. Dr. Parmar said: “Covid tends to trigger a dry, continuous cough. Many people cough for over an hour at a time or have three or more coughing episodes in a single day.”
The NHS defines this as: “A new, continuous cough—meaning you’re coughing a lot for more than an hour or have three or more coughing episodes within 24 hours.”
NHS officials are warning that the UK may be facing an unusually severe flu season. Cases have started a month earlier than usual, driven by a stronger strain of the influenza A(H3N2) virus, sometimes being called “super flu.” Despite its intensity, vaccines remain effective against this strain, offering protection to those who get immunized.
Other signs of Covid to watch for include:
The NHS warns: “Covid symptoms can resemble those of other illnesses like colds or flu. Most people recover within a few weeks, but some may take longer. If you have a cough, pharmacists can offer guidance on treatment.”
The NHS advises staying at home and avoiding contact with others if you or your child:
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The much-feared “winter vomiting disease,” commonly known as norovirus, is once again spreading rapidly across the United States.
Norovirus is an extremely contagious stomach virus that triggers sudden and intense episodes of vomiting and diarrhea. Anyone who has had it knows how abruptly it strikes. You can feel normal one moment and then find yourself completely incapacitated by stomach distress the next. With the holiday season nearing and people gathering indoors, norovirus infections are climbing nationwide.
Data from WastewaterSCAN, a program that tracks disease levels through municipal wastewater, shows that norovirus activity is currently classified as “high” across the U.S., with a sharp rise over the past three weeks. Marlene Wolfe, Ph.D., a professor at Emory University and director of WastewaterSCAN, told TODAY.com that the upward trend is clear and concerning.
At present, the highest levels are being recorded in the Midwest, the South, and the Northeast. States reporting notable spikes include Alabama, Connecticut, Florida, Indiana, Massachusetts, and Michigan.
In Bedford, Massachusetts, an elementary school shut down for two days this week after more than 130 students were absent with stomach-related symptoms, prompting officials to suspect a norovirus outbreak, according to NBC10 Boston. Cruise ships are also seeing a rise in outbreaks, with norovirus spreading quickly among passengers at sea.
This year’s increase appears to be arriving slightly earlier than usual and is likely linked to a newer strain of the virus, which drove a particularly severe 2024–2025 season. Last winter, norovirus cases reached their highest levels in more than a decade.
Since the early 2000s, most norovirus outbreaks have been linked to a strain known as GII.4, according to previous reports from NBC News. Roughly a decade ago, another strain called GII.17 first appeared in Asia and has expanded significantly in recent years. During the 2024–2025 season, GII.17 accounted for 75 percent of norovirus outbreaks in the U.S., compared with less than 10 percent in 2023, a CDC study found.
“When a new strain appears, it can spread very quickly,” Roberts says. “That is exactly what happened last year.”
Experts are unsure whether GII.17 spreads more easily than GII.4. However, they say more people may be vulnerable because they lack immunity to this newer variant.
Infection with norovirus does offer some level of immune protection, but it is incomplete, Schaffner explains.
“We do not know how long that immunity lasts,” Roberts says. “And it likely does not protect you against a different strain.”
If a large portion of the population is susceptible, the virus may have more opportunities to circulate widely. How this season unfolds remains uncertain.
“This is not a subtle illness,” Roberts says. Symptoms typically appear suddenly, usually within 12 to 48 hours of exposure.
Some common signs of norovirus are:
Some people may also experience a mild fever, chills, or headache, according to the CDC.
“The good news is that it does not usually last long,” Schaffner says. “Most people feel terrible for about two days, then recover.”
In most cases, symptoms resolve on their own within one to three days.
However, the virus can cause significant fluid loss, increasing the risk of dehydration. Certain groups face a higher risk of severe illness and hospitalization, including children under 5 and adults over 85.
Medical care should be sought if symptoms continue beyond a few days, if there is blood in vomit or stool, or if signs of dehydration appear, such as dizziness or dark urine, according to the Cleveland Clinic.
There is no medication that directly treats norovirus. Care focuses on managing symptoms through rest and fluid replacement, Roberts says. Drinks that replenish electrolytes can be helpful.
“It is better to take small sips,” Schaffner advises. “Drinking too much at once can make vomiting worse.”
In more serious cases, intravenous fluids may be necessary to prevent dehydration. Anyone with concerns should contact a health care provider, Schaffner adds.
There is currently no approved vaccine for norovirus, though a Moderna vaccine candidate is undergoing phase 3 clinical trials.
“It is an especially troublesome virus because it spreads so easily and in so many ways,” Schaffner says. An infected person can release billions of virus particles through vomit or stool. “It only takes one to ten particles to cause an infection,” he notes. Norovirus usually spreads through the fecal-oral route, Roberts explains, when virus particles from feces make their way into the mouth, often via unwashed hands.
Some common ways how the virus spread are:
People are most contagious from the time symptoms begin until a few days after they feel better. However, the virus can continue to be shed in stool for up to two weeks after recovery, Roberts says.
Norovirus can survive on surfaces, objects, and foods for extended periods. Foods frequently linked to outbreaks include leafy greens, fresh produce, and shellfish, according to the CDC.
Norovirus is especially difficult to eliminate. Alcohol-based hand sanitizers and cleaners are largely ineffective because the virus has a tough outer shell that alcohol cannot break down. “The only way to remove it from your hands is to physically wash it away,” Schaffner says. “Soap and water lift the virus off the skin and rinse it down the drain.”
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