Pregnancy is usually a time of happiness and hope, but it also brings in the unexpected. While there is much talk placed on the health of the expectant mother, the quality sperm coming from the father could dramatically change the outcome of pregnancy. The latest study suggests the risks of sperm DNA damage, even increasing the risks of complications preeclampsia and birth prematurity.

In a groundbreaking research study conducted by scientists from Lund University in Sweden, scientists discovered that DNA damage in sperm increases the risk almost up to double that of preeclampsia, this is a dangerous condition that may arise during pregnancies characterized by high blood pressure. In addition, DNA anomalies also increase the risk of premature births, and this further entails increased related adverse health outcomes for infants born through such conditions.

The next step would be to find out which group of men respond best to methods to prevent and treat sperm DNA damage, and to test these methods to prevent pregnancy complications," said Dr. Amelie Stenqvist, a lecturer at Lund University. According to this study, a significant message is put forward that paternal health assumes an important role in a successful pregnancy.

It focused its research on men, specifically whose sperm contained high levels of DNA fragmentation. For instance, some 20% to 30% of babies born via in vitro fertilization have fathers whose sperm contains damaged DNA. The DNA fragmentation index, an indicator to assess the percentage of DNA damage in sperm, indicated that when the percentage of sperm with a DFI above 30% was observed, they had almost no chance of resulting in natural conception. Even a DFI greater than 20% showed that the chances of getting pregnant are highly risky as the risk factor for pregnancy complications like preeclampsia is much high.

Uncommon Complications during Pregnancy

The most alarming complication during pregnancy is preeclampsia. It affects approximately 5% to 8% of pregnancies worldwide, which can cause fatal conditions for both the mother and the baby. The new findings now point out that sperm DNA damage may contribute to this condition, especially if it is due to assisted reproductive techniques such as IVF pregnancies. The research found that a DFI above 20% doubled the risk of preeclampsia from a mere 5% to almost 11% per.

Apart from causing preeclampsia, DNA fragmentation in sperm is also known to increase the risk for prematurity. Most premature babies experience respiratory, neurological, and developmental complications. Therefore, some degree of early intervention might be important for prospective parents.

Some of the rarer, though serious complications include placental abruption, which is the separation of the placenta from the uterine wall and intrauterine growth restriction, a condition by which the baby does not grow normally in the womb. These conditions though rare are potentially catastrophic both to the mother and the child. Results from this study may help in establishing the contribution of the father in such pregnancies.

Further study into sperm DNA damage is of urgent interest with regard to its consequences for pregnancy outcomes. According to Professor Aleksander Giwercman of Lund University in the field of Reproductive Medicine, "the analysis of DFI should be introduced as routine test in all fertility clinics.". "It could give answers to couples who are having difficulties with infertility, but our latest result also shows that DFI analysis can be a method to identify high-risk pregnancies, explained Giwercman.

For many, DNA fragmentation in sperm is often treatable. Common causes are oxidative stress, age, smoking, being obese, and infections. Addressing these elements will likely reduce DNA damage in sperm for men, raising the chances for a healthy pregnancy and baby.

Overall, the study importance should take into consideration paternal as well as maternal health towards reaching for a healthy pregnancy. Though DNA fragmentation in the sperm is supposed to increase the risk factors for complications in pregnancies, the advances into novel treatment approaches and tests are likely to alleviate complications in many families. Thus the findings of this study offer optimism and pave a pathway to more holistic fertility treatments in the future.

Diabetes develops when the body can no longer use food efficiently for energy. In this condition, the system either produces too little insulin or does not respond to it well enough. Insulin is the hormone that moves glucose into the cells, where it can be used as fuel. When glucose stays in the bloodstream instead of entering the cells, it begins to harm the blood vessels and nerves that support every organ, including the eyes.

This raises a natural question: can diabetes lead to blindness?

To understand how this happens and what people can do to prevent it, we spoke with Dr Arpan Dev Bhattacharya, Consultant in Diabetes and Endocrinology at Manipal Hospital in Bengaluru.

Can Diabetes Lead To Blindness?

High blood sugar, especially in people living with diabetes, can lead to serious eye problems and even permanent vision loss. When glucose stays elevated for long periods, it harms the fine network of blood vessels that nourish the retina. This injury is known as diabetic retinopathy, a condition that may begin with mild blurring and gradually progress to significant loss of sight if it is not treated in time.

Other eye diseases linked to diabetes include diabetic macular edema, cataracts, and glaucoma, each adding to the risk of visual decline.

Dr Arpan Dev Bhattacharya said, “Earliest changes almost always appear in the retina, the light-sensitive layer at the back of the eye. The vessels here are extremely delicate. When sugar levels remain high, these vessels become fragile or start to leak, creating the groundwork for diabetic retinopathy.”

Diabetes And Blindness: Early Warning Signs Are Easy to Miss

Diabetic eye disease often begins without noticeable symptoms. Some early clues include blurred or shifting vision, faded colours, difficulty seeing in low light, or small dark floaters that drift across the field of sight. These symptoms can come and go, which makes people dismiss them. Routine eye exams with dilation remain the most reliable way to detect trouble before vision begins to decline.

Blood Sugar Targets That Protect the Eyes

Good metabolic control offers the strongest defence. For most adults with diabetes, the recommended targets include an HbA1c below 7 percent, fasting glucose between 70 and 130 mg per decilitre, and post-meal readings under 180 mg per decilitre. According to Dr Bhattacharya, keeping blood pressure and cholesterol within recommended ranges also helps lower the risk of retinal complications.

Innovative Therapies For Treatment

Researchers are also studying whether certain diabetes medications may offer additional protection. Semaglutide, a GLP-1 receptor agonist widely used for type 2 diabetes and weight management, has drawn particular interest. Dr Bhattacharya said, “Early studies suggest it may reduce stress on retinal cells and slow processes linked to cell injury. Later reviews show that semaglutide does not significantly raise retinopathy risk when compared with other treatments, and some findings even point toward possible benefits. More clinical trials are underway to define its role.”

While new therapies may strengthen prevention strategies, the core advice remains unchanged. Consistent glucose control, regular screening, and timely care provide the best protection against vision loss.

Lone Star Tick disease: Scientists have verified the first known death tied to a serious meat allergy brought on by a tick bite. The man, who passed away in 2024 after eating a burger, had alpha-gal syndrome. This condition begins after certain tick bites and leads to dangerous allergic reactions to red meat and other foods made from animals. Two weeks before his death, he had already reacted badly after eating a steak.

“The sad part is that no one recognised that earlier incident as anaphylaxis, so it was never linked to the beef,” said study co-author Thomas Platts-Mills, an allergist at the University of Virginia School of Medicine who helped identify alpha-gal syndrome and diagnosed the New Jersey case, during an interview with NBC News. But how did he develop this condition in the first place?

Lone Star Tick: What Are Lone Star Ticks?

A tick marked with a small white dot is known as the lone star tick (Amblyomma americanum). Many people already know that certain tick species can threaten human health. Lone star ticks are mainly found in Texas and Oklahoma, stretching across the Southern states and moving up the Atlantic coastline to parts of Maine. They live in wooded regions and are most common from April to September.

Falling ill after a lone star tick bite can take several days or even a few weeks. A bite can trigger various problems, including a serious meat allergy known as alpha-gal syndrome.

Lone Star Tick: What Is Alpha Gal Syndrome?

Bites from lone star ticks can lead to another major effect. The bite can cause the body to develop an allergy to meat. Substances from the tick, including alpha-gal, enter the bloodstream when it bites, which alerts the immune system and prompts the body to create antibodies to the alpha-gal molecule. Humans do not naturally produce this sugar, so the body treats it as foreign.

This reaction can make a person allergic to the sugar. Alpha-gal is present in many common foods, including beef, pork, lamb, dairy products, and gelatin. Once the allergy develops, a person can fall sick after eating these foods.

Experts believe that many people with alpha-gal syndrome have no idea they carry it. In the New Jersey case, it took scientists months to confirm that the man had the syndrome and had died as a result of it. Warmer winters have also allowed ticks to remain active for longer periods, raising the chances of bites throughout the year.

Anyone who thinks they may have this allergy can undergo testing to check. Although there is no cure for alpha-gal syndrome, doctors advise people with the condition to avoid all forms of meat, as well as dairy, gelatin, and some medicines that include these ingredients.

Lone Star Tick: How To Know if You Have the Alpha-Gal Allergy

Many people never realise they were bitten, unless a rash becomes visible. The symptoms of alpha-gal syndrome vary widely and may take weeks to appear, which makes it difficult to diagnose.

Signs of an alpha-gal allergy can include gastrointestinal discomfort after eating foods such as:

• Dairy products, which trouble about 10 to 20 percent of individuals with the allergy
• Red meats like beef, pork, lamb, or venison
• Foods and items that contain gelatin

Other signs may involve hives or, in severe situations, anaphylaxis. The allergy can take four to six weeks to form after the tick bite. Reactions may also be delayed for several hours after a person eats the food that triggers it.

A healthcare professional can test for the alpha-gal IgE antibody through a blood sample. Food challenge tests may also be carried out under medical supervision, in case a severe reaction occurs.

Doctors usually recommend taking daily medications in the morning, making it part of a morning routine. However, recent research suggests that taking blood pressure (BP) medications at night may provide additional cardiovascular protection. Still, consistency like taking your BP medicine at the same time every day—is more important than whether it’s morning or evening.

Numerous studies have examined the timing of BP medications, but none have produced conclusive evidence favoring morning or evening doses. To gain more insight, we spoke with Dr. Kiran Aithal, Vice Principal, Professor, and HOD of General Medicine at SDMCMS&H, SDM University, Dharwad who shared his perspective on the topic.

When Is The Best Time To Take Blood Pressure Medicine?

One of the largest trials, including over 21,000 participants, did not find clear evidence that taking BP medication in the morning is superior to taking it at night. Dr. Kiran suggests linking the timing to a daily activity that’s hard to forget, like breakfast or dinner, so doses aren’t missed. Skipping a dose is a common reason for hypertensive emergencies.

Dr Kiran said, “Sometimes, patients on multiple BP medications may need to split doses between morning and night, following the doctor’s instructions. Certain drugs, such as diuretics, are advised in the morning as they can increase urination. In some patients whose blood pressure doesn’t naturally dip at night (detectable through Ambulatory BP monitoring), physicians may recommend taking medication at night to achieve better control. Following your doctor’s advice is key.”

In general, most BP medications can be taken either in the morning or evening. The critical factor is taking them consistently at the same time every day to prevent complications. It’s important to remember that hypertension cannot be cured but can be effectively controlled. Lifestyle changes combined with regular, timely medication are crucial for managing high blood pressure successfully.

What Should You Avoid While Taking Blood Pressure Medicine?

Certain foods, drinks, and medications can interfere with blood pressure medicines. These include grapefruit juice, high-potassium foods, and salt substitutes, as well as alcohol and caffeine. Over-the-counter drugs like decongestants and NSAIDs (such as ibuprofen or naproxen) should also be avoided.

Some herbal supplements, including St. John’s Wort and licorice, can affect your blood pressure, and recreational drugs should be completely avoided. Always check with your doctor or pharmacist before starting any new medication, supplement, or making significant changes to your diet, says the Heart Organisation.

Understanding Blood Pressure Categories

Blood pressure is measured using two numbers: systolic (the top number) and diastolic (the bottom number). Based on these readings, blood pressure is classified as normal, elevated, or high. A normal reading is below 120/80 mmHg. Elevated blood pressure falls between 120–129 systolic with a diastolic under 80. Stage 1 hypertension is defined as 130–139 systolic or 80–89 diastolic, while Stage 2 hypertension is 140 or higher systolic or 90 or higher diastolic.

Readings of 180/120 or above are considered a hypertensive crisis and require immediate medical attention, according to the Heart Organisation.

Disclaimer: This article is for informational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always consult your healthcare provider before making any changes to your medication, diet, or lifestyle.