Can Damaged Sperm Lead To Pregnancy Complications? Study Highlights Uncommon Issues

Updated Oct 17, 2024 | 02:00 AM IST

SummaryDamaged sperm DNA increases the risk of complications such as preeclampsia and premature birth, even doubling it, according to a new study. These findings could make a difference in the execution of fertility treatments and delivery outcomes.
Can Damaged Sperm Lead To Pregnancy Complications?`

Can Damaged Sperm Lead To Pregnancy Complications?

Pregnancy is usually a time of happiness and hope, but it also brings in the unexpected. While there is much talk placed on the health of the expectant mother, the quality sperm coming from the father could dramatically change the outcome of pregnancy. The latest study suggests the risks of sperm DNA damage, even increasing the risks of complications preeclampsia and birth prematurity.

In a groundbreaking research study conducted by scientists from Lund University in Sweden, scientists discovered that DNA damage in sperm increases the risk almost up to double that of preeclampsia, this is a dangerous condition that may arise during pregnancies characterized by high blood pressure. In addition, DNA anomalies also increase the risk of premature births, and this further entails increased related adverse health outcomes for infants born through such conditions.

The next step would be to find out which group of men respond best to methods to prevent and treat sperm DNA damage, and to test these methods to prevent pregnancy complications," said Dr. Amelie Stenqvist, a lecturer at Lund University. According to this study, a significant message is put forward that paternal health assumes an important role in a successful pregnancy.

It focused its research on men, specifically whose sperm contained high levels of DNA fragmentation. For instance, some 20% to 30% of babies born via in vitro fertilization have fathers whose sperm contains damaged DNA. The DNA fragmentation index, an indicator to assess the percentage of DNA damage in sperm, indicated that when the percentage of sperm with a DFI above 30% was observed, they had almost no chance of resulting in natural conception. Even a DFI greater than 20% showed that the chances of getting pregnant are highly risky as the risk factor for pregnancy complications like preeclampsia is much high.

Uncommon Complications during Pregnancy

The most alarming complication during pregnancy is preeclampsia. It affects approximately 5% to 8% of pregnancies worldwide, which can cause fatal conditions for both the mother and the baby. The new findings now point out that sperm DNA damage may contribute to this condition, especially if it is due to assisted reproductive techniques such as IVF pregnancies. The research found that a DFI above 20% doubled the risk of preeclampsia from a mere 5% to almost 11% per.

Apart from causing preeclampsia, DNA fragmentation in sperm is also known to increase the risk for prematurity. Most premature babies experience respiratory, neurological, and developmental complications. Therefore, some degree of early intervention might be important for prospective parents.

Some of the rarer, though serious complications include placental abruption, which is the separation of the placenta from the uterine wall and intrauterine growth restriction, a condition by which the baby does not grow normally in the womb. These conditions though rare are potentially catastrophic both to the mother and the child. Results from this study may help in establishing the contribution of the father in such pregnancies.

Further study into sperm DNA damage is of urgent interest with regard to its consequences for pregnancy outcomes. According to Professor Aleksander Giwercman of Lund University in the field of Reproductive Medicine, "the analysis of DFI should be introduced as routine test in all fertility clinics.". "It could give answers to couples who are having difficulties with infertility, but our latest result also shows that DFI analysis can be a method to identify high-risk pregnancies, explained Giwercman.

For many, DNA fragmentation in sperm is often treatable. Common causes are oxidative stress, age, smoking, being obese, and infections. Addressing these elements will likely reduce DNA damage in sperm for men, raising the chances for a healthy pregnancy and baby.

Overall, the study importance should take into consideration paternal as well as maternal health towards reaching for a healthy pregnancy. Though DNA fragmentation in the sperm is supposed to increase the risk factors for complications in pregnancies, the advances into novel treatment approaches and tests are likely to alleviate complications in many families. Thus the findings of this study offer optimism and pave a pathway to more holistic fertility treatments in the future.

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Mental Health Crisis: 1 in 5 Adolescents Turning To AI For Advice

Updated Jun 2, 2026 | 12:00 PM IST

SummaryA recent survey by the research institute RAND shows that 1 in 5 adolescents and young people use AI chatbots for mental health advice. The survey was published in the journal JAMA Pediatrics.
Mental Health Crisis: 1 in 5 Adolescents Turning To AI For Advice

Credits: Health and me

Mental health is a very important aspect of life, and the society at large, but a recent survey has shed light on the current state of mental health in adolescents and young adults. The survey of RAND was published in the journal JAMA Pediatrics. The survey finds that 1 in 5 adolescents and young people is using an AI chatbot for mental health.

The organization also did a similar survey back in 2025, but then about 13% of respondents admitted to using a chatbot for advice; that number has jumped up to 19% this year. The 63% of them confessed that they did not tell anyone about taking therapy from a chatbot.

Ryan McBain, a senior policy researcher at RAND and the lead author of the study, said, “It’s a sad number, because you’d hope that young people would have the sorts of supportive relationships that they would feel comfortable and empowered reaching out to those around them.”

McBain and his team asked people aged between 12 and 21 years about their use of AI chatbots, including ChatGPT, Google Gemini, or Character.AI, for mental health advice. They also asked whether the advice from the chatbots was helpful, and the majority of participants felt that the suggestions were useful.

Also Read: Study Finds Healthy Lifestyle Reduces Cardiovascular Risk In Childhood Cancer Survivors

Habits To Boost Mental Health

  • Quality sleep is essential not just for physical health but also for emotional stability. Establishing a consistent sleep schedule, creating a comfortable sleep environment, and limiting caffeine intake in the evenings can promote better rest and overall well-being.

  • Reducing social media usage is another effective strategy. Constant exposure to curated glimpses of other people’s lives can lead to unhealthy comparisons and feelings of inadequacy, increasing anxiety and depression.

  • Human connection plays a vital role in mental well-being. Strong relationships provide emotional support, reduce loneliness, and add meaning to life.

  • Regular physical activity offers significant mental health benefits. Exercise does not have to be intense; enjoyable activities such as walking, dancing, yoga, or even stretching can positively impact mental well-being.
Also Read: Space Grown Stem Cells: How Are Expedition 74 Astronauts Helping To Fight Cancer?

  • Diet also plays a crucial role in mental health. Nutrient-rich foods, such as berries, bananas, beans, whole grains, and fatty fish, contain mood-boosting properties. Staying hydrated is equally important, as dehydration can lead to fatigue and cognitive difficulties.

  • Knowing when to take a step back is equally essential. Some days may feel overwhelming, making even the simplest tasks seem daunting. Practicing self-compassion can prevent feelings of guilt and frustration from accumulating.

  • Rest is critical for mental restoration. Engaging in mindfulness practices or setting aside quiet time can create a sense of calm amid daily responsibilities.

  • Spending time outdoors, even briefly, can also uplift mental well-being. Stepping outside for a few minutes, taking a short walk, or simply opening a window can provide a refreshing mental boost.

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Potential 'Functional Cure' For Hepatitis B: Trial Give Hope To Millions

Updated Jun 2, 2026 | 10:15 AM IST

SummaryThe recent publication of a research paper on a drug trial has given hope to millions of patients with chronic hepatitis B for a functional cure.
Potential 'Functional Cure' For Hepatitis B: Trials Give Hope To Millions

Credit: AI Generated Image

Over one million Americans have contracted chronic hepatitis B and are now forced to go through a lifelong treatment process. Though these treatment only helps in terminating the virus, the risk of liver cancer stays on, and the constant fear and torment remain. Now, a new study of a drug trial for hepatitis B patients has given hope to millions.

The trial saw 1 in 5 patients with chronic hepatitis B infection getting cured. The 24-week test had 1,838 patients from 29 countries in Asia, Europe, and North and South America. The research published in the New England Journal of Medicine concluded that 20% of patients got a functional cure, and no virus was detected in them after 48 hours.

The drug, bepirovirsen, is made by Ionis Pharmaceuticals and GlaxoSmithKline and can stop the virus from replicating itself while giving the immune system a chance to eradicate it. The treatment process will be done by administering an injection once a week. Notably, GlaxoSmithKline has already applied to the Food and Drug Administration for approval to market the drug.

Though there was an option of vaccination to prevent the disease, still, millions are infected. This effective functional cure option will be a great addition to the treatment of hepatitis B.

Also Read: Space Grown Stem Cells: How Are Expedition 74 Astronauts Helping To Fight Cancer?

What Is Hepatitis B?

Hepatitis B is a viral infection that affects the liver. Many adults can clear the virus after an acute infection. Some, however, go on to develop chronic hepatitis B, which increases the risk of liver cancer, liver failure, and cirrhosis, or permanent scarring of the liver.

Also Read: Study Finds Healthy Lifestyle Reduces Cardiovascular Risk In Childhood Cancer Survivors

How Is Hepatitis B Spread?

The hepatitis B virus is highly contagious. It spreads when blood, semen, or other bodily fluids from a person who carries the virus enter the body of someone who is not infected.

Certain medical conditions, personal habits, and other circumstances can raise the risk, such as injection drug use or sexual contact, but the virus can infect anyone. Hepatitis B can also pass from an infected mother to her baby during childbirth, whether through a vaginal delivery or a C-section.

How Can Hepatitis B Be Prevented?

Vaccination is the most reliable way to prevent hepatitis B. The shots offer strong protection in infancy and continue to shield individuals well into adulthood. Babies usually receive a three-dose series.

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Study Finds Healthy Lifestyle Reduces Cardiovascular Risk In Childhood Cancer Survivors

Updated Jun 2, 2026 | 08:00 AM IST

SummaryTwo new studies have found that childhood cancer survivors can drastically reduce the risk of cardiovascular disease if they lead a healthy lifestyle.
Study Finds Healthy Lifestyle Reduces Cardiovascular Risk In Childhood Cancer Survivors

Credit: AI Generated Image

A healthy lifestyle is very crucial for any human being, but for cancer survivors, it's a must, as they tend to get various diseases, including cardiovascular ones. A recent study by the University of Gothenburg and St. Jude Children's Research Hospital also doubles down on this aspect. Their research reveals that a healthy lifestyle can significantly lower the risk of diseases like cardiovascular disease in childhood cancer survivors.

The study published in Nature Communications observed over 18,000 childhood cancer survivors for 30 days. The results clearly show that most of the chronic health problems among childhood cancer survivors revolve around lifestyle. Those with a habit of inactivity, obesity, smoking, and high alcohol intake are likely to catch diseases.

Aron Onerup, Pediatrician and Researcher at the University of Gothenburg and former Postdoctoral Fellow at St. Jude Children's Research Hospital in Memphis, said, "This reveals that lifestyle plays a much bigger role than previously thought. Unlike the treatments already given, the lifestyle can actually be changed."

Also Read: Space Grown Stem Cells: How Are Expedition 74 Astronauts Helping To Fight Cancer?

Another study published in JACC: CardioOncology with 2,300 cancer survivor participants finds that those who do not exercise regularly are 1.4 times more likely to contract a cardiovascular disease. The disease burden in childhood cancer survivors who do not exercise is twelve times more than that of the general population.

Aron Onerup, a Researcher within Pediatrics at Sahlgrenska Academy at the University of Gothenburg and a Specialist Physician at the Pediatric Cancer Center at Queen Silvia Children's Hospital, Sahlgrenska University Hospital, in Gothenburg, said, "This means that physical activity can make a big difference in reducing the extra risk that emerges after cancer treatment and modify the negative effects from cancer treatments. Our results provide strong scientific support for offering survivors structured support for healthy lifestyles."

Also Read: Vitamin B12 And Folate Deficiencies Behind Chronic Fatigue, New Study Finds

Why Women Are More Likely To Develop Cardiovascular Diseases?

Cardiovascular diseases are the number one reason for death among women and men, according to the Centers for Disease Control and Prevention (CDC). Statistics show that about 44% women are living with heart diseases, and it is responsible for the death of 1 in 5 women.

There are many risk factors for heart diseases, like high blood pressure, which often goes undiagnosed in women. While studies have shown that women are more likely to live longer, even with diseases, a recent report shared how women are also more likely to have cardiovascular diseases than men.

According to the study published in the American College of Cardiology, even though women often try to live healthier, if they have issues like bad food habits or high blood pressure, their risk of heart disease goes up much more than it does for men.

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