Pregnancy is usually a time of happiness and hope, but it also brings in the unexpected. While there is much talk placed on the health of the expectant mother, the quality sperm coming from the father could dramatically change the outcome of pregnancy. The latest study suggests the risks of sperm DNA damage, even increasing the risks of complications preeclampsia and birth prematurity.

In a groundbreaking research study conducted by scientists from Lund University in Sweden, scientists discovered that DNA damage in sperm increases the risk almost up to double that of preeclampsia, this is a dangerous condition that may arise during pregnancies characterized by high blood pressure. In addition, DNA anomalies also increase the risk of premature births, and this further entails increased related adverse health outcomes for infants born through such conditions.

The next step would be to find out which group of men respond best to methods to prevent and treat sperm DNA damage, and to test these methods to prevent pregnancy complications," said Dr. Amelie Stenqvist, a lecturer at Lund University. According to this study, a significant message is put forward that paternal health assumes an important role in a successful pregnancy.

It focused its research on men, specifically whose sperm contained high levels of DNA fragmentation. For instance, some 20% to 30% of babies born via in vitro fertilization have fathers whose sperm contains damaged DNA. The DNA fragmentation index, an indicator to assess the percentage of DNA damage in sperm, indicated that when the percentage of sperm with a DFI above 30% was observed, they had almost no chance of resulting in natural conception. Even a DFI greater than 20% showed that the chances of getting pregnant are highly risky as the risk factor for pregnancy complications like preeclampsia is much high.

Uncommon Complications during Pregnancy

The most alarming complication during pregnancy is preeclampsia. It affects approximately 5% to 8% of pregnancies worldwide, which can cause fatal conditions for both the mother and the baby. The new findings now point out that sperm DNA damage may contribute to this condition, especially if it is due to assisted reproductive techniques such as IVF pregnancies. The research found that a DFI above 20% doubled the risk of preeclampsia from a mere 5% to almost 11% per.

Apart from causing preeclampsia, DNA fragmentation in sperm is also known to increase the risk for prematurity. Most premature babies experience respiratory, neurological, and developmental complications. Therefore, some degree of early intervention might be important for prospective parents.

Some of the rarer, though serious complications include placental abruption, which is the separation of the placenta from the uterine wall and intrauterine growth restriction, a condition by which the baby does not grow normally in the womb. These conditions though rare are potentially catastrophic both to the mother and the child. Results from this study may help in establishing the contribution of the father in such pregnancies.

Further study into sperm DNA damage is of urgent interest with regard to its consequences for pregnancy outcomes. According to Professor Aleksander Giwercman of Lund University in the field of Reproductive Medicine, "the analysis of DFI should be introduced as routine test in all fertility clinics.". "It could give answers to couples who are having difficulties with infertility, but our latest result also shows that DFI analysis can be a method to identify high-risk pregnancies, explained Giwercman.

For many, DNA fragmentation in sperm is often treatable. Common causes are oxidative stress, age, smoking, being obese, and infections. Addressing these elements will likely reduce DNA damage in sperm for men, raising the chances for a healthy pregnancy and baby.

Overall, the study importance should take into consideration paternal as well as maternal health towards reaching for a healthy pregnancy. Though DNA fragmentation in the sperm is supposed to increase the risk factors for complications in pregnancies, the advances into novel treatment approaches and tests are likely to alleviate complications in many families. Thus the findings of this study offer optimism and pave a pathway to more holistic fertility treatments in the future.

Men planning to conceive should practise caution while consuming antioxidant supplements, as excessive intake may affect sperm and early craniofacial development in babies, a Frontiers in Cell and Developmental Biology study shows.

Antioxidants are often promoted as powerful supplements that can help protect the body from chronic conditions, including cancer, chronic obstructive pulmonary disease and dementia.

However, researchers at the Texas A&M College of Veterinary Medicine and Biomedical Sciences (VMBS) found that consuming high levels of the antioxidant compounds N-acetyl-L-cysteine (NAC) and selenium (Se) can alter skull and facial shape in female children, even though the treated fathers did not exhibit obvious health problems.

Dr Michael Golding, a professor in the VMBS’ Department of Veterinary Physiology and Pharmacology, whose research team made the discovery said: "We know alcohol causes oxidative stress and we were looking to push back on it by adding a supplement known to lower oxidative stress.

"When we realized that offspring born to males that had only been given NAC were displaying skull and facial differences, it was a surprise because this molecule is universally thought to be good.

“When we sat down to think it through, we realized that it makes sense — you take a multivitamin to ensure that you’re in balance, but if the thing that you’re taking to ensure you’re in balance is unbalanced (the dose of antioxidants is too high), then you’re not doing a good thing.

“Sperm health is another performance metric; it’s just not one that we think about in everyday life. If you’re taking a high-dose antioxidant, you could be diminishing your reproductive fitness, and part of the journey toward the bad outcome is going to be the effects on the offspring.”

What Are Antioxidants?

Antioxidants are important because they protect the fundamental structure of the human body, cells. They safeguard an individual's DNA and proteins from the damage caused by free radicals.

Research has shown that a diet high in antioxidants may help individuals prevent chronic diseases and mental health issues. But on the contrary, having too many antioxidants in your body could confuse your cells' responses, leading to more damage than intented.

How Do Antioxidants Protect Your Body?

Antioxidants basically neutralize free radicals in the body. These free radicals are extra atoms that are produced during the body's internal processes and also by some external factors.

Overproduction of these free radicals, during the process of oxidation in the human body, damages cell membranes and other structures, including cellular proteins, lipids and DNA. Oxidation can be exacerbated by stress, smoking, alcohol, sunlight and pollution.

In the long run, they can lead to diseases such as cancer and heart diseases. It is pertinent to note that the brain is prone to oxidative stress due to its high metabolic activity. Here, the role of antioxidants becomes particularly important as they fight oxidative stress which could otherwise lead to stroke, traumatic brain injury or neurodegenerative diseases like Alzheimer's.

If you take large amounts of antioxidants, then it could hamper the cell's defence mechanisms and normal signalling. Different types of antioxidants also have different properties, so they may not be interchangeable. Therefore, health experts advise people to be mindful of the amount of antioxidant-rich food they are including in your diet. Notably, studies have found that antioxidant supplements have a lower impact such as natural food items.

Here Are Top 10 Antioxidant Rich Food:

• Blueberries: Packed with anthocyanins, which help fight oxidative stress and inflammation.
• Dark Chocolate (70 percent cacao or higher): Rich in flavonoids, known for their heart health and antioxidant properties.
• Spinach: Contains vitamins C and E, flavonoids, and carotenoids, all potent antioxidants.
• Nuts (especially almonds and walnuts): High in vitamin E and other antioxidant compounds that protect cells from damage.
• Green Tea: Loaded with polyphenols, particularly catechins, which are powerful antioxidants.
• Kale: Full of vitamins A, C, and K, along with flavonoids, which support immune function.
• Tomatoes: Rich in lycopene, a carotenoid antioxidant that supports skin health and may reduce the risk of certain cancers.
• Carrots: High in beta-carotene, which is converted to vitamin A and offers strong antioxidant benefits.
• Avocados: Packed with healthy fats, vitamin E, and carotenoids, helping to reduce oxidative stress.
• Pomegranates: Contain punicalagins and anthocyanins, powerful antioxidants that may help lower inflammation and improve heart health.

A simple biomarker blood test can now detect dementia in women 25 years before symptoms appear, a JAMA study suggests.

Researchers from the University of California San Diego have found a protein in the blood called plasma phosphorylated tau 217 (p-tau217), a protein linked to the brain changes seen in Alzheimer’s disease.

The researchers found a strong association between higher levels of p-tau217 in the blood and a higher chance of developing both mild cognitive impairment (MCI) and dementia, a key contributer in the developemnt of Alzheimer’s.

Neuroscientist Linda McEvoy, from the Kaiser Permanente Washington Health Research Institute: "Blood-based biomarkers like p-tau217 are especially promising because they are far less invasive and potentially more accessible than brain imaging or spinal fluid tests.

"This is important for accelerating research into the factors that affect risk of dementia and for evaluating strategies that may reduce risk."

The connection between higher p-tau217 and dementia was stronger in women over 70, the researchers also found, and in those carrying the APOE ε4 gene that has been linked to Alzheimer's disease in the past.

What Is Dementia?

Dementia is an umbrella term used to describe a significant decline in mental function that is serious enough to affect everyday life. It commonly impacts memory, thinking, and reasoning skills.

Dementia itself is not a single disease but a collection of symptoms caused by underlying conditions such as Alzheimer’s disease or vascular dementia.

Common signs include memory problems, confusion, difficulty finding words, changes in mood or behaviour and trouble completing familiar tasks.

These symptoms usually worsen over time and are not considered a normal part of ageing. Although there is no cure, treatment options can help manage symptoms, and early diagnosis plays an important role in care planning.

Alzheimer’s Disease: The Leading Cause of Dementia

Alzheimer's disease is one of the most common forms of dementia and mostly affects adults over the age of 65.

About 8.8 million Indians aged 60 and above are estimated to be living with Alzheimer's disease. Over seven million people in the US 65 and older live with the condition and over 100,00 die from it annually.

Alzheimer's disease is believed to be caused by the development of toxic amyloid and beta proteins in the brain, which can accumulate in the brain and damage cells responsible for memory.

Amyloid protein molecules stick together in brain cells, forming clumps called plaques. At the same time, tau proteins twist together in fiber-like strands called tangles. The plaques and tangles block the brain's neurons from sending electrical and chemical signals back and forth.

Over time, this disruption causes permanent damage in the brain that leads to Alzheimer's disease and dementia, causing patients to lose their ability to speak, care for themselves or even respond to the world around them.

While there is no clear cause of Alzheimer's disease, experts believe it can develop due to genetic mutations and lifestyle choices, such as physical inactivity, unhealthy diet and social isolation.

Early symptoms of Alzheimer's disease include forgetting recent events or conversations. Over time, Alzheimer's disease leads to serious memory loss and affects a person's ability to do everyday tasks.

There is no cure for this progressive brain disorder and in advanced stages, loss of brain function can cause dehydration, poor nutrition or infection. These complications can result in death.

Once seen only among the elderly, glaucoma, also known as irreversible blindness, is increasing among younger adults in their 20s and 30s, said experts.

Glaucoma is a chronic disease that affects an estimated 80 million individuals globally, according to the World Glaucoma Association.

Beyond the role of genetics, unhealthy lifestyles with increased screen time and stress are the major reasons for the rise in glaucoma cases in young adults.

"We have seen an increasing incidence of glaucoma among younger adults in their 20s and 30s because of lifestyle habits such as increased screen time and lack of sleep, an increase in diabetes and high blood pressure, and a genetic predisposition," Dr. Mahipal Singh Sachdev, Chairman & Medical Director, Centre For Sight Group of Eye Hospitals, told HealthandMe.

Why Is Treatment Difficult

A major challenge with glaucoma is its lack of symptoms in the initial stages. As a result, the condition is often diagnosed at an advanced stage, where treatment yields the least results.

More than 75 percent of glaucoma cases globally remain undiagnosed.

Although the condition does not directly lead to mortality, glaucoma-led blindness is categorized as a severe form of disability (category VI) out of seven World Health Organization (WHO) classifications on the global burden of diseases.

"Often referred to as a silent thief of sight, glaucoma usually has no warning signs until the damage to the optic nerve has already caused permanent vision loss," Sachdev said.

"Because there are no noticeable symptoms in the early stages of glaucoma, many people have been unaware that they are developing it until it has progressed to a point where there is already significant damage and vision loss; this often translates to blindness," he added.

However, increased awareness of glaucoma and increased frequency of eye examinations have helped reduce the time between the onset of the disease and the diagnosis, the expert said.

Glaucoma: Are Children At Risk?

Although rare, children can be born with congenital or paediatric glaucoma as a result of ocular drainage abnormalities.

Dr Devindra Sood, Senior Consultant — Ophthalmology, Max Multi Speciality Centre, Panchsheel Park, told HealthandMe that glaucoma in children is uncommon.

"Its presentation for diagnosis and treatment is also different from that in adults," Sood said.

The symptoms of pediatric glaucoma include:

• enlargement of the globe,
• excessive lacrimation,
• photophobia,
• corneal cloudiness.

Sood stated that traditionally, large eyes are considered to harbor glaucoma.

These children usually do not respond to medical treatment, and surgical intervention is required.

However, early detection and treatment of congenital glaucoma are vital to reducing the risk of permanent visual impairment, Sachdeva said.

Glaucoma: A Global Health Burden

It is a progressive, degenerative disorder of the optic nerve that produces characteristic visual field damage.

The chronic disease affects an estimated 80 million individuals globally. By the year 2040, it is estimated that there will be 22 million individuals worldwide who are blind from glaucoma.

In India, around 12 million people suffer from glaucoma, and 1.5 million are blind due to it.

When to see a doctor for glaucoma:

• Vision suddenly gets blurry

• Severe eye pain

• Headache

• Nausea

• Vomiting

• Rainbow-colored rings or halos around lights.