Can Damaged Sperm Lead To Pregnancy Complications?
Pregnancy is usually a time of happiness and hope, but it also brings in the unexpected. While there is much talk placed on the health of the expectant mother, the quality sperm coming from the father could dramatically change the outcome of pregnancy. The latest study suggests the risks of sperm DNA damage, even increasing the risks of complications preeclampsia and birth prematurity.
In a groundbreaking research study conducted by scientists from Lund University in Sweden, scientists discovered that DNA damage in sperm increases the risk almost up to double that of preeclampsia, this is a dangerous condition that may arise during pregnancies characterized by high blood pressure. In addition, DNA anomalies also increase the risk of premature births, and this further entails increased related adverse health outcomes for infants born through such conditions.
The next step would be to find out which group of men respond best to methods to prevent and treat sperm DNA damage, and to test these methods to prevent pregnancy complications," said Dr. Amelie Stenqvist, a lecturer at Lund University. According to this study, a significant message is put forward that paternal health assumes an important role in a successful pregnancy.
It focused its research on men, specifically whose sperm contained high levels of DNA fragmentation. For instance, some 20% to 30% of babies born via in vitro fertilization have fathers whose sperm contains damaged DNA. The DNA fragmentation index, an indicator to assess the percentage of DNA damage in sperm, indicated that when the percentage of sperm with a DFI above 30% was observed, they had almost no chance of resulting in natural conception. Even a DFI greater than 20% showed that the chances of getting pregnant are highly risky as the risk factor for pregnancy complications like preeclampsia is much high.
Uncommon Complications during Pregnancy
The most alarming complication during pregnancy is preeclampsia. It affects approximately 5% to 8% of pregnancies worldwide, which can cause fatal conditions for both the mother and the baby. The new findings now point out that sperm DNA damage may contribute to this condition, especially if it is due to assisted reproductive techniques such as IVF pregnancies. The research found that a DFI above 20% doubled the risk of preeclampsia from a mere 5% to almost 11% per.
Apart from causing preeclampsia, DNA fragmentation in sperm is also known to increase the risk for prematurity. Most premature babies experience respiratory, neurological, and developmental complications. Therefore, some degree of early intervention might be important for prospective parents.
Some of the rarer, though serious complications include placental abruption, which is the separation of the placenta from the uterine wall and intrauterine growth restriction, a condition by which the baby does not grow normally in the womb. These conditions though rare are potentially catastrophic both to the mother and the child. Results from this study may help in establishing the contribution of the father in such pregnancies.
Further study into sperm DNA damage is of urgent interest with regard to its consequences for pregnancy outcomes. According to Professor Aleksander Giwercman of Lund University in the field of Reproductive Medicine, "the analysis of DFI should be introduced as routine test in all fertility clinics.". "It could give answers to couples who are having difficulties with infertility, but our latest result also shows that DFI analysis can be a method to identify high-risk pregnancies, explained Giwercman.
For many, DNA fragmentation in sperm is often treatable. Common causes are oxidative stress, age, smoking, being obese, and infections. Addressing these elements will likely reduce DNA damage in sperm for men, raising the chances for a healthy pregnancy and baby.
Overall, the study importance should take into consideration paternal as well as maternal health towards reaching for a healthy pregnancy. Though DNA fragmentation in the sperm is supposed to increase the risk factors for complications in pregnancies, the advances into novel treatment approaches and tests are likely to alleviate complications in many families. Thus the findings of this study offer optimism and pave a pathway to more holistic fertility treatments in the future.
Credit: AI generated image
There is a particular cruelty about ovarian cancer. It does not announce itself loudly. Instead, it murmurs softly with a bit of bloating here, some lower back pain there, a persistent sense that something is not quite right, but nothing dramatic enough to cause alarm. And by the time most women receive a diagnosis, the disease has often made itself very much at home.
Every year on May 8th, the world pauses to mark World Ovarian Cancer Day, an occasion that has grown since its launch in 2013 into a genuinely global movement. This year’s theme – ‘No Woman Left Behind’ – carries particular weight because the uncomfortable truth is that far too many women are being left behind by late diagnoses, by underfunded research, and by healthcare systems that have historically paid less attention to this disease than it deserves.
Roughly 250,000 women are diagnosed with ovarian cancer every year across the world. An estimated 140,000 will die from it. It is, by some measures, the deadliest of all gynecological cancers, and yet, it receives a fraction of the public attention given to breast cancer.
The comparison is worth dwelling on. Approximately 89 per cent of breast cancer patients survive beyond five years. For ovarian cancer, that figure drops to around 45 per cent – nearly half! And the primary reason for that stark difference is not that ovarian cancer is inherently untreatable but that it is rarely caught in its early stages.
When diagnosed at Stage I before the cancer has spread beyond the ovaries, survival rates climb dramatically, with some studies suggesting above 90 per cent. The problem is that only around 20 per cent of cases are caught that early. The rest are diagnosed at Stage III or Stage IV, when the cancer has already spread to the abdomen, lymph nodes, or beyond.
Ask most people to name the symptoms of ovarian cancer, and you will likely be met with a blank look. That in itself is part of the problem. Unlike the distinct lump in breast cancer cases or the irregular bleeding associated with cervical and uterine cancer, ovarian cancer does not produce one clear and recognizable sign. What it does produce are symptoms that most of us would simply dismiss – persistent bloating, feeling full quickly when eating, pelvic or lower abdominal pain, urge to urinate more frequently or urgently, unexplained fatigue, and a change in bowel habits.
Each of those individually could be attributed to several other conditions, including irritable bowel syndrome, gut infections, stress, dietary changes, and even getting older. That is precisely what makes this disease so dangerous. Women dismiss these symptoms. Sometimes doctors do too.
This is not about blame; it is about recognition. The medical community has made genuine progress in understanding ovarian cancer, but there simply aren’t any reliable early-screening tests available that are similar to mammograms for breast cancer or smear tests for cervical cancer. Hence, genuine and widespread public awareness becomes the closest thing to building a first line of defense.
The 2026 theme is not merely a slogan. It is a confrontation with the reality that a woman’s place of residence, country, or economic circumstances should not determine whether or not she lives.
In higher-income countries, access to surgery and chemotherapy, whilst still imperfect, is broadly available. Newer treatments are beginning to extend survival times for women with advanced disease. Research into biomarkers is advancing, offering hope for earlier detection in the future.
But in lower-income countries, the picture is vastly different. Women are often diagnosed later, treated less effectively, and supported less comprehensively. The global survival gap for ovarian cancer is not simply a medical problem; it is more a problem of justice.
‘No Woman Left Behind’ asks us to hold that in mind. Progress that only reaches the privileged is not progress enough.
The absence of a reliable screening test makes personal awareness all the more essential. There are several things every woman can do, not just on May 8 but throughout the year.
Since 2013, World Ovarian Cancer Day has grown into a movement that now spans more than 80 per cent of the world’s countries and is supported by over 200 organizations globally. That is an extraordinary thing. It is proof that sustained, collective attention can shift awareness, influence policy, and ultimately change outcomes.
But awareness days only work if they spark something beyond the day itself. The teal ribbons and social media posts matter, not because they are gestures, but because every gesture has the potential to reach someone who needs to hear it, someone whose bloating has been going on for two months, someone whose mother was diagnosed with breast cancer and who has never thought to ask whether their own risk might be elevated. Someone who simply did not know.
Therefore, let us spread awareness this day by realizing that equality is not in regarding different things similarly, equality is in regarding different things differently, and still leaving no one behind.
Frequent bloating is a cause of concern. (Photo credit: AI generated)
Many women do not consider persistent bloating to be a serious issue because they tend to correlate their symptoms with acidity, excessive gas, overeating, or other temporary issues caused by their digestive system. Many women tend to treat their symptoms on their own by changing their diet or taking over-the-counter medications without looking into what the underlying problem may be. Many women do this because their symptoms initially seem mild. However, it is important to pay attention to any persistent bloating, especially if the bloating occurs on a regular basis, has lasted for at least one month, or is associated with symptoms such as pelvic discomfort, loss of appetite, an increased feeling of fullness, or irregular bowel habits (diarrhoea, constipation, etc.).
In an interaction with Health and Me, Dr Parnamita Bhattacharya, Gynaecologist at CK Birla Hospitals, CMRI, spoke about the concerns surrounding persistent bloating and whether it is associated with the risk of ovarian cancer.
One of the most significant concerns surrounding persistent bloating is that women can develop ovarian cancer, especially in the early stages, without knowing or having any obvious signs that they have the disease. Because there are no routine screening tests to detect ovarian cancer in the general population, it is critical for women to be on the lookout for any symptoms of persistent bloating and report them immediately to their doctor. Unfortunately, because women often ignore their symptoms and fail to seek medical attention, by the time they do see a doctor, ovarian cancer has progressed to a later stage of development.
Not all bloating is related to ovarian cancer. Other common contributing factors to bloating include irritable bowel syndrome, food intolerance, hormonal changes, and lifestyle factors. The significant difference between "normal" bloating and "abnormal" bloating is how long each type of bloating lasts and how quickly the symptoms progress. If your bloating continues despite dietary changes, or if it increases in frequency, you should not ignore the symptoms. You should have them evaluated by a medical professional.
It is important for women to understand the signals sent by their bodies. If you frequently experience bloating, this issue needs to be investigated and not just accepted as normal. If you seek timely evaluation, doctors can determine the source of your problem early on, which greatly increases your chances of a good outcome from a serious diagnosis such as ovarian cancer.
Ovarian cancer symptoms can be vague and may develop as the disease progresses. Therefore, timely detection is a challenge. Some of the signs of ovarian cancer include:
Credit: AP
Former New York City Mayor Rudy Giuliani has been discharged from the ICU but will remain in the hospital for “some time” as he recovers from pneumonia, according to his spokesperson.
In a post on social media platform X, spokesperson Ted Goodman said Giuliani, 81, was hospitalized earlier this week in critical but stable condition.
Giuliani, who served as New York City's mayor from 1994 to 2001, was previously diagnosed with restrictive airway disease following the infamous 9/11 terrorist incident, where he “took down the mafia, saved New York City, and ran toward the towers on September 11th".
However, the incident left Giuliani with lasting health complications, Goodman said, adding that the former NYC Mayor "is recovering from pneumonia”.
“The virus quickly overwhelmed his body, requiring mechanical ventilation to maintain adequate oxygen and stabilize his condition,” Goodman said.
Calling him the "same fighter he's always been, and he's winning this fight,” Goodman said that the "mayor and his family appreciate the outpouring of love and prayers sent his way”.
Notably, Giuliani is a longtime ally of President Donald Trump. In 2025, Trump also announced awarding Giuliani with the Presidential Medal of Freedom, the country's highest civilian honor.
Pneumonia is an inflammatory condition of the lung tissue, most often caused by infections. It can affect one or both lungs and can range from mild to life-threatening, especially in vulnerable populations like the elderly, young children, or those with underlying health conditions.
There are several types of pneumonia, classified based on their causes—bacterial, viral, and fungal—and each has distinct patterns of transmission and severity.
Pneumonia is not a single disease but a syndrome resulting from various infectious agents:
Bacterial Pneumonia: This is the most common type, often developing as a secondary infection after a cold or flu. Streptococcus pneumoniae is the most frequent culprit.
Viral Pneumonia: Caused by viruses like influenza, respiratory syncytial virus (RSV), and SARS-CoV-2 (COVID-19), this type often starts in the upper respiratory tract and spreads to the lungs.
Fungal Pneumonia: This type is less common and usually affects individuals with weakened immune systems. It's typically contracted through environmental exposure, such as to soil or bird droppings.
Pneumonia can be insidious. It often begins with symptoms that mimic the flu: headache, fatigue, and fever. But as the infection progresses, signs become more serious:
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