Pregnancy is usually a time of happiness and hope, but it also brings in the unexpected. While there is much talk placed on the health of the expectant mother, the quality sperm coming from the father could dramatically change the outcome of pregnancy. The latest study suggests the risks of sperm DNA damage, even increasing the risks of complications preeclampsia and birth prematurity.

In a groundbreaking research study conducted by scientists from Lund University in Sweden, scientists discovered that DNA damage in sperm increases the risk almost up to double that of preeclampsia, this is a dangerous condition that may arise during pregnancies characterized by high blood pressure. In addition, DNA anomalies also increase the risk of premature births, and this further entails increased related adverse health outcomes for infants born through such conditions.

The next step would be to find out which group of men respond best to methods to prevent and treat sperm DNA damage, and to test these methods to prevent pregnancy complications," said Dr. Amelie Stenqvist, a lecturer at Lund University. According to this study, a significant message is put forward that paternal health assumes an important role in a successful pregnancy.

It focused its research on men, specifically whose sperm contained high levels of DNA fragmentation. For instance, some 20% to 30% of babies born via in vitro fertilization have fathers whose sperm contains damaged DNA. The DNA fragmentation index, an indicator to assess the percentage of DNA damage in sperm, indicated that when the percentage of sperm with a DFI above 30% was observed, they had almost no chance of resulting in natural conception. Even a DFI greater than 20% showed that the chances of getting pregnant are highly risky as the risk factor for pregnancy complications like preeclampsia is much high.

Uncommon Complications during Pregnancy

The most alarming complication during pregnancy is preeclampsia. It affects approximately 5% to 8% of pregnancies worldwide, which can cause fatal conditions for both the mother and the baby. The new findings now point out that sperm DNA damage may contribute to this condition, especially if it is due to assisted reproductive techniques such as IVF pregnancies. The research found that a DFI above 20% doubled the risk of preeclampsia from a mere 5% to almost 11% per.

Apart from causing preeclampsia, DNA fragmentation in sperm is also known to increase the risk for prematurity. Most premature babies experience respiratory, neurological, and developmental complications. Therefore, some degree of early intervention might be important for prospective parents.

Some of the rarer, though serious complications include placental abruption, which is the separation of the placenta from the uterine wall and intrauterine growth restriction, a condition by which the baby does not grow normally in the womb. These conditions though rare are potentially catastrophic both to the mother and the child. Results from this study may help in establishing the contribution of the father in such pregnancies.

Further study into sperm DNA damage is of urgent interest with regard to its consequences for pregnancy outcomes. According to Professor Aleksander Giwercman of Lund University in the field of Reproductive Medicine, "the analysis of DFI should be introduced as routine test in all fertility clinics.". "It could give answers to couples who are having difficulties with infertility, but our latest result also shows that DFI analysis can be a method to identify high-risk pregnancies, explained Giwercman.

For many, DNA fragmentation in sperm is often treatable. Common causes are oxidative stress, age, smoking, being obese, and infections. Addressing these elements will likely reduce DNA damage in sperm for men, raising the chances for a healthy pregnancy and baby.

Overall, the study importance should take into consideration paternal as well as maternal health towards reaching for a healthy pregnancy. Though DNA fragmentation in the sperm is supposed to increase the risk factors for complications in pregnancies, the advances into novel treatment approaches and tests are likely to alleviate complications in many families. Thus the findings of this study offer optimism and pave a pathway to more holistic fertility treatments in the future.

Obesity is a very significant modifiable risk factor for brain stroke, which is an extremely dangerous illness caused by an insufficient or lack of blood supply to the brain. Stroke leads to disability, memory impairment, paralysis, and sometimes death. As obesity is related to many illnesses, regulation of weight can considerably decrease the probability of suffering a brain stroke.

Dr Bhupesh Kumar Mansukhani, Director of Neurology at Neuromet Wellness Care & Diagnostics, in an interview with Health and Me, said, "Obesity is an excessive accumulation of fat in the body, which causes damage to health. Obesity is determined using the BMI index. Those who suffer from obesity are more prone to illnesses like hypertension, diabetes, and elevated cholesterol levels, all of which put people at a higher risk of suffering a brain stroke. Excessive fat, particularly abdominal fat, affects the arteries, leading to their constriction."

Can hypertension trigger a stroke?

Hypertension, or high blood pressure, is yet another major connection between obesity and stroke. Obesity causes stress on the cardiovascular system and elevates blood pressure levels. Such a state poses a risk of injury to the blood vessels in the brain, causing their rupture or blockage. Obesity usually results in diabetes, and both conditions harm the walls of the blood vessels and increase the risk of blood clot formation. Besides, the increased concentration of cholesterol contributes to plaque accumulation in the arteries.

The presence of obesity in the body stimulates inflammatory reactions and reduces the rate of circulation, which may cause the formation of blood clots. As a result, these clots are delivered to the brain and prevent blood from delivering oxygen to it, and ischaemia becomes the trigger for an ischaemic stroke, which is the leading type of stroke.

Is obesity a modifiable risk factor?

The advantage here is that obesity is a modifiable risk factor, which can actually be avoided or managed. Proper nutrition, physical exercise, adequate sleep, and the absence of negative behaviours will enable an individual to maintain a healthy body weight. It is also important to take part in preventive measures, such as having regular medical examinations and testing one’s blood pressure, glucose levels, and cholesterol.

To conclude, it can be noted that obesity contributes significantly to increased risks of developing a brain stroke due to many reasons, including hypertension, diabetes mellitus, and vascular diseases. Being a modifiable risk factor, it can be easily avoided.

Cancer is, without a doubt, one of the most feared diseases known to man. According to the Indian Council of Medical Research - National Cancer Registry Programme (ICMR-NCRP), India gets 1.5 million new cases of the disease every year, with one in nine people likely to develop cancer in their lifetime. On the other hand, the American Cancer Society (ACS) and National Cancer Institute (NCI) expect about 2,114,850 new cases in the United States this year alone.

A new study claims that the weight loss drug, glucagon-like peptide-1 (GLP-1), may help slow the spread of some cancers. The research was done by the Cleveland Clinic and claimed that the medications may slow down the spread of several obesity-related cancers, including lung, breast, colorectal, and liver cancers.

The official press release by the Cleveland Clinic mentions their research being included 12,112 patients with the following types of obesity-related cancers, ranging from stage 1 to stage 3, and half of these participants started a GLP-1 medication after their cancer diagnosis. The others were taking a DPP-4 inhibitor comparator, "gliptins," a different class of diabetes medications.

The comparison between the two groups clearly shows that the patients who took GLP-1 have a much lower progression to stage 4 disease for four types of cancers.

The study author, Mark David Orland, MD, of the Taussig Cancer Institute at Cleveland Clinic, said, "Our study found that use of GLP-1 drugs, compared to DPP-4 inhibitors and other antidiabetic drugs, was associated with a meaningful reduction in cancer progression across four solid tumor types."

How To Reduce The Risk Of Cancer?

• Consuming a healthy and balanced diet rich in fruits, vegetables, whole grains, and lean proteins can reduce cancer risk.
• Regular physical activity keeps the body fit and reduces the risk of breast, colon, and endometrial cancers.
• Smoking and alcohol consumption should be avoided.
• Skin cancer is one of the most preventable types of cancer. Applying sunscreen with high SPF, finding shade, and avoiding tanning beds would save you from harmful ultraviolet rays.
• Long-term stress can weaken the immune system and may contribute to an increased risk of cancer. Incorporating stress-relief techniques such as mindfulness, practising deep-breathing exercises, and engaging in enjoyable hobbies can enhance overall well-being.
• Exposure to environmental elements like pesticides, pollutants, and workplace chemicals can increase the risk of cancer. To avoid this risk, wearing protective gear, opting for organic produce, and ensuring adequate ventilation in living or working areas can greatly assist.
• By vaccinating against Hepatitis B and HPV, individuals can protect themselves against infections closely linked to liver and cervical cancers; apart from vaccination, adopting proper hygiene practices and steering clear of high-risk activities can help prevent the risk of cancer-causing infections.

As summer heat intensifies both in India and globally, many people may experience unusual heart sensations such as a racing heartbeat, chest fluttering, skipped beats, or pounding sensations, even while resting.

Speaking to HealthandMe, Dr. L.K. Jha, Associate Director and Head Unit-II, Cardiology, Asian Hospital, Faridabad, said that heatwaves can significantly increase the risk of heart palpitations.

Normal healthy people may experience occasional mild palpitations due to heat exposure, which usually resolve with rest, fluids, and cooling off. However, experts warn that when palpitations are accompanied by symptoms such as chest pain, loss of consciousness, shortness of breath, extreme light-headedness, or recurring episodes while resting, they may indicate an underlying cardiac rhythm issue requiring medical attention.

“The association between heatwaves and palpitations occurs more frequently than people think,” Dr. Jha said.

Dehydration: A Key Risk Factor

The human body constantly works to maintain a stable internal temperature.

During extreme heat, blood vessels dilate to release heat through the skin, while the heart pumps faster to circulate blood and cool the body. According to Dr. Jha, this additional strain on the cardiovascular system can make the heartbeat feel stronger or irregular, especially in people sensitive to heat.

Also read: Heatwave In India: Temperatures Continuously Rising; Stay Hydrated, Says PM Modi

Dr. Jha explained that dehydration is one of the biggest contributors to heat-related palpitations.

Excessive sweating leads to the loss of water and essential electrolytes such as sodium, potassium, and magnesium, all of which are crucial for maintaining a normal heart rhythm.

“Dehydration can lower blood pressure, forcing the heart to beat faster, which may cause dizziness, shakiness, or pounding sensations,” he said.

Existing Health Conditions Can Increase Risk

Heatwaves may also worsen existing conditions such as anxiety, thyroid disorders, anemia, diabetes, and heart disease, increasing the likelihood of palpitations.

Certain medications, including blood pressure drugs, diuretics, asthma inhalers, as well as excessive consumption of caffeine or energy drinks, may further contribute to irregular heartbeats during hot weather, Dr. Jha told HealthandMe.

Sleep disturbances caused by hot nights can also trigger stress hormones in the body, potentially leading to rapid heartbeat episodes or fluttering sensations.

Also read: Climate Change Fueling Chikungunya Spread To Europe, North America, Warns Study

When To Seek Medical Help?

Dr. Jha noted that occasional mild palpitations due to heat exposure are common and often improve with rest, hydration, and cooling down.

Doctors recommend drinking fluids regularly, replenishing electrolytes through coconut water, buttermilk, lemon water, or Oral Rehydration Salts (ORS), avoiding prolonged sun exposure, and limiting caffeine and alcohol intake during heatwaves.

However, persistent or severe palpitations may indicate a more serious condition.

“If palpitations are accompanied by chest pain, shortness of breath, fainting, severe light-headedness, or repeated episodes while resting, immediate medical evaluation is necessary,” Dr. Jha warned.

He added that some heat-related palpitations may actually signal an underlying heart rhythm disorder requiring treatment.

Yellow Alert In Delhi; Heat Dome in Europe

Meanwhile, the India Meteorological Department (IMD) has issued a yellow alert for heatwave conditions in Delhi.

Heatwave conditions in the national capital are expected to continue till tomorrow, with maximum temperatures remaining between 44 and 46 degrees Celsius.

The IMD forecast also includes relief in the form of thunderstorms, dust storms, and light rainfall from May 28 evening onwards.

At the same time, European countries like France, the United Kingdom, Spain, and Germany are experiencing early heatwaves and record-breaking conditions.

The sweltering heat conditions have affected scores of people, reportedly resulting in the deaths of about seven people in France. The unusually high temperatures early in May are being triggered by a phenomenon called a “heat dome”.

As a result, southern and southwestern regions, including Portugal, Spain, and France, will experience daytime temperature highs of 38°C. The majority of France is under a moderate to high temperature warning, while Germany and the UK are witnessing maximum temperatures exceeding 30°C, the Euronews reported.