Can Damaged Sperm Lead To Pregnancy Complications?
Pregnancy is usually a time of happiness and hope, but it also brings in the unexpected. While there is much talk placed on the health of the expectant mother, the quality sperm coming from the father could dramatically change the outcome of pregnancy. The latest study suggests the risks of sperm DNA damage, even increasing the risks of complications preeclampsia and birth prematurity.
In a groundbreaking research study conducted by scientists from Lund University in Sweden, scientists discovered that DNA damage in sperm increases the risk almost up to double that of preeclampsia, this is a dangerous condition that may arise during pregnancies characterized by high blood pressure. In addition, DNA anomalies also increase the risk of premature births, and this further entails increased related adverse health outcomes for infants born through such conditions.
The next step would be to find out which group of men respond best to methods to prevent and treat sperm DNA damage, and to test these methods to prevent pregnancy complications," said Dr. Amelie Stenqvist, a lecturer at Lund University. According to this study, a significant message is put forward that paternal health assumes an important role in a successful pregnancy.
It focused its research on men, specifically whose sperm contained high levels of DNA fragmentation. For instance, some 20% to 30% of babies born via in vitro fertilization have fathers whose sperm contains damaged DNA. The DNA fragmentation index, an indicator to assess the percentage of DNA damage in sperm, indicated that when the percentage of sperm with a DFI above 30% was observed, they had almost no chance of resulting in natural conception. Even a DFI greater than 20% showed that the chances of getting pregnant are highly risky as the risk factor for pregnancy complications like preeclampsia is much high.
Uncommon Complications during Pregnancy
The most alarming complication during pregnancy is preeclampsia. It affects approximately 5% to 8% of pregnancies worldwide, which can cause fatal conditions for both the mother and the baby. The new findings now point out that sperm DNA damage may contribute to this condition, especially if it is due to assisted reproductive techniques such as IVF pregnancies. The research found that a DFI above 20% doubled the risk of preeclampsia from a mere 5% to almost 11% per.
Apart from causing preeclampsia, DNA fragmentation in sperm is also known to increase the risk for prematurity. Most premature babies experience respiratory, neurological, and developmental complications. Therefore, some degree of early intervention might be important for prospective parents.
Some of the rarer, though serious complications include placental abruption, which is the separation of the placenta from the uterine wall and intrauterine growth restriction, a condition by which the baby does not grow normally in the womb. These conditions though rare are potentially catastrophic both to the mother and the child. Results from this study may help in establishing the contribution of the father in such pregnancies.
Further study into sperm DNA damage is of urgent interest with regard to its consequences for pregnancy outcomes. According to Professor Aleksander Giwercman of Lund University in the field of Reproductive Medicine, "the analysis of DFI should be introduced as routine test in all fertility clinics.". "It could give answers to couples who are having difficulties with infertility, but our latest result also shows that DFI analysis can be a method to identify high-risk pregnancies, explained Giwercman.
For many, DNA fragmentation in sperm is often treatable. Common causes are oxidative stress, age, smoking, being obese, and infections. Addressing these elements will likely reduce DNA damage in sperm for men, raising the chances for a healthy pregnancy and baby.
Overall, the study importance should take into consideration paternal as well as maternal health towards reaching for a healthy pregnancy. Though DNA fragmentation in the sperm is supposed to increase the risk factors for complications in pregnancies, the advances into novel treatment approaches and tests are likely to alleviate complications in many families. Thus the findings of this study offer optimism and pave a pathway to more holistic fertility treatments in the future.
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Bruce Willis was diagnosed with frontotemporal dementia in 2022. His wife, Emma Heming Willis recalled the day when Bruce was diagnosed with the condition and how it made her feel "lost, isolated and afraid." Talkin to PEOPLE, Emma said, Bruce "never connected the dots" that he has been diagnosed with frontotemporal dementia. “I think that's like the blessing and the curse of this, is that he never connected the dots that he had this disease, and I'm really happy about that. I'm really happy that he doesn't know about it,” she shared about Bruce, 70.
"On the day Bruce got his diagnosis, we walked out of the doctor's office with a pamphlet and an empty goodbye. No plan, no guidance, no hope, just shock," she explained in front of a packed auditorium, People reported.
In one instant, the family's future disappeared. The Oscar-winning actor, famous for his quick wit and performances in Die Hard and The Sixth Sense, would be leaving his career behind. Emma found herself thrust into a whole new role of full-time caregiver at the same time.
She continued to explain, "I found myself having to keep my family intact, raise our two small girls, and tend to the man that I love while dealing with an illness I hardly knew anything about."
Emma's emotional candor resonated with hundreds of families who have received similar diagnoses and encouraged her to author a book, The Unexpected Journey, scheduled for publication in September. In Emma's words, "This is the book I hope will assist the next caregiver. It is packed with encouragement, wisdom, and the encouragement necessary to walk this path.
Frontotemporal dementia is a less prevalent type of dementia that mainly occurs in the frontal and temporal lobes of the brain. It tends to affect behavior, personality, language, and movement more than memory, particularly in its initial stages.
In contrast to Alzheimer's, which generally strikes older individuals, FTD can hit at an earlier age—sometimes as young as 40. The symptoms can range from changes in personality, emotional flatness, or the inability to show empathy to impulsiveness, so it is especially hard for spouses and children to cope.
Emma's case illustrates how abrupt and disrupting this diagnosis can be—not only for the patient but for caregivers as well.
Whereas Bruce Willis' diagnosis hit global headlines, the mental toll taken by Emma, his caregiver, was largely in the background—until she decided to come forward.
Caregiving is a respectable position, but it's also a challenging and thankless one. For those who are caring for loved ones with dementia or other chronic illnesses, the stress of "keeping it all together" can result in a condition called caregiver burnout.
"Caring for someone is the most intimate and demanding work of love," Emma explained, "but when you're not noticed or supported, it begins to undermine your health—mentally and physically."
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Work stress could make you gay, said a Malaysian minister Zulkifli Hasan, as continued government intervention of what is described as 'sexually deviant behavior' has pressured the country's LGBTQ community. This happened two weeks after religious authorities and police acted on complaints from a sultan and Islamist politicians that a camping retreat was promoting the LGBTQ lifestyle, reported South China Morning Post.
Religious Affairs Minister Hasan on Tuesday said that work stress could be among many other factors that is pushing people into sexual orientations other than heterosexuality. “Societal influence, sexual experiences, work stress and other personal factors come under this category [of possible causes],” Zulkifli said in a written parliamentary reply to a question by Siti Zailah Mohd Yusoff, a lawmaker with the opposition Islamist party PAS.
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He cited a 2017 study by Sulaiman et.al., that said such elements "can contribute to the increase in LGBT acts".
His comments have attracted a lot of backlash, with many people on social media mocking him. A social media user Muaz Zam said, "By this logic, I am genuinely shocked my entire office isn't gay by now". Another one read: "In other words: they never work hard in the parliament."
However, these claims are not scientifically back. Work related stress can impact a person, but cannot change their sexuality. It can, however, cause health effects. What it does not do is change one's sexuality and this is why one should know the difference about gender, sex and sexual orientation or sexuality.

While these both terms are often used interchangeably in official forms, there is a difference between the two.
As per the Council of Europe, gender is an area that cuts across thinking about society, law, politics, and culture.
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The World Health Organization notes that sex refers to: "the different biological and physiological characteristics of males and females, such as reproductive organs, chromosomes, hormones, etc.”
Whereas, gender refers to: "the socially constructed characteristics of women and men – such as norms, roles and relationships of and between groups of women and men. It varies from society to society and can be changed. The concept of gender includes five important elements: relational, hierarchical, historical, contextual and institutional. While most people are born either male or female, they are taught appropriate norms and behaviours – including how they should interact with others of the same or opposite sex within households, communities and work places. When individuals or groups do not “fit” established gender norms they often face stigma, discriminatory practices or social exclusion – all of which adversely affect health."
“Sex refers to the biological and physiological characteristics that define humans as female or male. These sets of biological characteristics are not mutually exclusive, as there are individuals who possess both, but these characteristics tend to differentiate humans as females or males.”
“Gender refers to the social attributes and opportunities associated with being female and male and to the relationships between women and men and girls and boys, as well as to the relations between women and those between men. These attributes, opportunities and relationships are socially constructed and are learned through socialisation processes. They are context- and time-specific, and changeable. Gender determines what is expected, allowed and valued in a woman or a man in a given context. In most societies, there are differences and inequalities between women and men in responsibilities assigned, activities undertaken, access to and control over resources, as well as decision-making opportunities. Gender is part of the broader sociocultural context. Other important criteria for sociocultural analysis include class, race, poverty level, ethnic group and age.”
The main difference is that gender is a social construct, whereas sex is the biologically labelled term based on organs and hormones.
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As per the American Psychological Association (APA), sexuality is the capacity to derive pleasure from various forms of sexual activity and behavior. The Lanarkshire Sexual Health describes sexual orientation as a way to describe the feelings you have for someone you fancy or are attached to.
While sexuality can change overtime, it is not a choice. There is no evidence that sexual orientation can be forced to change through therapy.
While stress can impact sexual function by reducing libido, causing fatigue, and triggering hormonal changes, it does not change one's sexual orientation. Jason Teoh, who writes on LGBTQ issues, project partner at NSW Department of Planning, Housing and Infrastructure, notes: "Sexual orientation is not caused by stress. It is not caused by trauma, influence or difficult life circumstances."
The WHO notes: sexual orientation is a natural, stable part of human identity shaped by biology, genetics, and early development. The WHO removed homosexuality from its disease classification in 1990. The American Psychiatric Association did the same in 1973.
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Parkinson's disease is a progressive, neurodegenerative movement disorder caused by the loss of dopamine-producing brain cells, primarily affecting people over 60. Apart from motor loss, the disease also causes cognitive decline, depression, anxiety and swallowing problems.
The first symptom may be a barely noticeable tremor in just one hand or sometimes a foot or the jaw. Over time, swinging your arms may become difficult and your speech may become soft or slurred. The disorder also causes stiffness, slowing of movement and trouble with balance that raises the risk of falls.
However, before clear symptoms begin to appear, Neurologist Rachel Dolhun says certain signs may help identify the onset of the disease decades before it is diagnosed.
“It’s important to stress that not everyone who has these symptoms goes on to develop Parkinson’s,” said neurologist Rachel Dolhun. “But we know that in some people, these can be some of the earliest signs," she told The Washington Post.
Here is what you should look out for:
Loss of smell, or hyposmia, is a common and early non-motor symptom of Parkinson's disease, affecting up to 90 percent of patients. This symptom can significantly impact quality of life by reducing the enjoyment of food and diminishing appetite.
While strongly linked to Parkinson's, smell loss can also stem from other causes, including sinus problems, COVID-19, or aging.
Acting out dreams, known as REM Sleep Behavior Disorder (RBD), involves physically enacting vivid, often unpleasant dreams through shouting, punching, or kicking during sleep.
This typically happens because the brainstem fails to temporarily paralyze muscles during REM sleep. It is a strong early warning sign of Parkinson's disease, often appearing years or decades before motor symptoms. About 50 percent of people with Parkinson's experience RBD.
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Constipation is a very common and significant non-motor symptom of Parkinson's disease that is caused by nerve changes slowing gut muscles and potentially exacerbated by low activity and dehydration.
Constipation can also be caused by Parkinson's medications such as anticholinergics, amantadine and other common drugs such as opioids, iron/calcium antacids.
The autonomic nervous system fails to properly constrict blood vessels or increase heart rate upon standing, often due to a lack of norepinephrine. This causes the autonomic nervous system to fail in regulating blood pressure. Over time, this leads to Neurogenic Orthostatic Hypotension.
Beyond dizziness, symptoms include blurred vision, weakness, fatigue, cognitive "fog," and "coat hanger pain" (pain in the neck/shoulders). Often times, patients experience dizziness in the morning or immediately after meals.
Diagnosing Parkinson’s disease is mostly a clinical process, meaning it relies heavily on a healthcare provider examining your symptoms, asking questions and reviewing your medical history. Various imaging and diagnostic tests used to detect disease includes CT scan, PET scan, MRI scan and genetic testing.
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