Pregnancy is usually a time of happiness and hope, but it also brings in the unexpected. While there is much talk placed on the health of the expectant mother, the quality sperm coming from the father could dramatically change the outcome of pregnancy. The latest study suggests the risks of sperm DNA damage, even increasing the risks of complications preeclampsia and birth prematurity.

In a groundbreaking research study conducted by scientists from Lund University in Sweden, scientists discovered that DNA damage in sperm increases the risk almost up to double that of preeclampsia, this is a dangerous condition that may arise during pregnancies characterized by high blood pressure. In addition, DNA anomalies also increase the risk of premature births, and this further entails increased related adverse health outcomes for infants born through such conditions.

The next step would be to find out which group of men respond best to methods to prevent and treat sperm DNA damage, and to test these methods to prevent pregnancy complications," said Dr. Amelie Stenqvist, a lecturer at Lund University. According to this study, a significant message is put forward that paternal health assumes an important role in a successful pregnancy.

It focused its research on men, specifically whose sperm contained high levels of DNA fragmentation. For instance, some 20% to 30% of babies born via in vitro fertilization have fathers whose sperm contains damaged DNA. The DNA fragmentation index, an indicator to assess the percentage of DNA damage in sperm, indicated that when the percentage of sperm with a DFI above 30% was observed, they had almost no chance of resulting in natural conception. Even a DFI greater than 20% showed that the chances of getting pregnant are highly risky as the risk factor for pregnancy complications like preeclampsia is much high.

Uncommon Complications during Pregnancy

The most alarming complication during pregnancy is preeclampsia. It affects approximately 5% to 8% of pregnancies worldwide, which can cause fatal conditions for both the mother and the baby. The new findings now point out that sperm DNA damage may contribute to this condition, especially if it is due to assisted reproductive techniques such as IVF pregnancies. The research found that a DFI above 20% doubled the risk of preeclampsia from a mere 5% to almost 11% per.

Apart from causing preeclampsia, DNA fragmentation in sperm is also known to increase the risk for prematurity. Most premature babies experience respiratory, neurological, and developmental complications. Therefore, some degree of early intervention might be important for prospective parents.

Some of the rarer, though serious complications include placental abruption, which is the separation of the placenta from the uterine wall and intrauterine growth restriction, a condition by which the baby does not grow normally in the womb. These conditions though rare are potentially catastrophic both to the mother and the child. Results from this study may help in establishing the contribution of the father in such pregnancies.

Further study into sperm DNA damage is of urgent interest with regard to its consequences for pregnancy outcomes. According to Professor Aleksander Giwercman of Lund University in the field of Reproductive Medicine, "the analysis of DFI should be introduced as routine test in all fertility clinics.". "It could give answers to couples who are having difficulties with infertility, but our latest result also shows that DFI analysis can be a method to identify high-risk pregnancies, explained Giwercman.

For many, DNA fragmentation in sperm is often treatable. Common causes are oxidative stress, age, smoking, being obese, and infections. Addressing these elements will likely reduce DNA damage in sperm for men, raising the chances for a healthy pregnancy and baby.

Overall, the study importance should take into consideration paternal as well as maternal health towards reaching for a healthy pregnancy. Though DNA fragmentation in the sperm is supposed to increase the risk factors for complications in pregnancies, the advances into novel treatment approaches and tests are likely to alleviate complications in many families. Thus the findings of this study offer optimism and pave a pathway to more holistic fertility treatments in the future.

While vaccinations against human papillomavirus (HPV) are key to preventing cervical cancers in women, a new study has shown that the shots can also lead to a significant risk of head and neck cancers in men and boys.

The study, published in JAMA Oncology, showed that men and boys who received the HPV vaccine from ages nine to 26 were nearly 50 per cent less likely to develop cancers of the head and neck, esophagus, anus, or penis.

The results show the importance of vaccinating all children and teens against HPV, said Taito Kitano, DrPH, first author of the study and a researcher at Nara Prefecture General Medical Center in Nara, Japan, CIDRAP News reported.

“Children, adolescents, parents, and health care workers should be more informed about the expected benefits of the HPV vaccine, not just cervical cancer,” Kitano added.

The study included more than 510,000 boys and men vaccinated between January 2016 and December 2024, along with an equal number of unvaccinated males.

Vaccinated participants in the study were given shots that prevent infection with nine strains of HPV.

What Are HPV-related Cancers in Men

HPV-related head and neck cancers often develop in the back of the mouth and throat. They are asymptomatic in the early stages and are typically found only after they cause pain or swelling.

However, by the time these symptoms begin to appear, the cancers are often larger and more advanced, making them harder to cure.

Earlier this year, the European Cancer Organization noted in a LinkedIn post urged for HPV vaccine for all people, regardless of gender.

"HPV affects everyone, regardless of gender. It can lead to cancers of the cervix, mouth and throat, anus, and penis. This is why universal protection is so important," it said.

According to Dr David Pfister, an oncologist at Memorial Sloan Kettering Cancer Centre, New York, the HPV vaccine protects men from penile, neck, and head cancer. He also noted that while a pap test detects early-stage cervical cancer in women, no such test exists for penile, anal, or head and neck cancers in men, which can worsen their survival rate.

"Developing something like a pap test for throat cancer would be a game-changer. When you compare the throat to the cervix, the anatomy of sites like the tonsils and the base of the tongue has hard-to-reach crevices in which the virus can hide," Dr Pfister explained.

"Until an effective and reliable screening test is developed, patients should stay up to date on their HPV vaccines, know how the disease is acquired, and take any suspicious symptoms like a lump in the neck or blood in the phlegm to their doctor or dentist," he added.

The findings have important implications for vaccination policies. HPV vaccination programs have focused primarily on women because of the link between HPV and cervical cancers. The study provides evidence that HPV vaccination should be accessible irrespective of sex.

Growing fatty liver disease in India is significantly affecting both male and female fertility, said doctors ahead of World Liver Day.

World Liver Day is observed annually on April 19 to raise global awareness about liver-related diseases, the importance of early detection, and preventive measures. The liver is the second largest organ in the body and a vital "silent worker," often showing no signs of damage until late stages.

With nearly one in three adults is affected by fatty liver, the silent disease is now emerging as an important but often ignored cause behind infertility in India.

Poor liver health is causing health issues, such as irregular periods in women and falling sperm counts in men, affecting their reproductive health.

Rising Liver Disease Cases

A recent study published in The Lancet Gastroenterology & Hepatology journal showed that the Metabolically Dysfunctional-Associated Steatotic Liver Disease (MASLD), formerly known as non-alcoholic fatty liver disease (NAFLD), affected 1.3 billion people around the globe in 2023.

India has also shown a sharp rise in MASLD prevalence, up 23.19 per cent from 1990 to 2023. India’s age-standardized MASLD prevalence rate rose from 10,191 per 100,000 in 1990 to 12,555 per 100,000 in 2023.

The findings show that the spike is increasingly driven by rising metabolic risk factors, including high blood sugar and obesity.

The alarming study estimates the numbers to further spike by over 38 percent to reach 1.8 billion cases by 2050, causing substantial health and economic impacts worldwide.

“We are seeing a big increase in fatty liver cases, even in younger people in their late 20s and 30s. Earlier, it was mostly seen in older patients, but now, due to poor lifestyle and diet habits, it is becoming very common in the young population also in India,” said Dr. Saurabh Singhal, Senior Consultant & Director, Centre for Liver-GI Diseases and Transplantation (CLDT) at Aakash Healthcare.

Also read: NAFLD to MASLD: Experts Explain Why This Common Yet Dangerous Liver Condition Got Renamed

"Almost every second patient we see has some degree of fatty liver. Many people do not even know they have it because it shows very few symptoms in the early stage. That is why it is called a silent disease,” added Dr Amit Miglani, Director & HOD, Gastroenterology, Asian Hospital, Faridabad.

Impact On Women’s Fertility

In India, around 8 per cent of women face infertility, and doctors are now seeing a strong link between fatty liver and difficulty in conceiving. The problem is more common in women with PCOS.

Dr. Hrishikesh Pai, Consultant Gynecologist & IVF Specialist, Lilavati Hospital, Mumbai, explains, “In women, fatty liver is closely linked with hormonal imbalance. We are seeing more patients with Polycystic Ovary Syndrome and irregular periods, where fatty liver is also present. This affects ovulation and makes it difficult to conceive.”

The doctors noted fatty liver affects how the body handles insulin and hormones, which are very important for regular periods and pregnancy.

Impact On Male Fertility

Infertility is no longer only a woman’s issue. In India, 30-40 per cent of infertility cases are linked to men, and doctors say cases are rising.

As per the experts, liver problems directly affect hormones like testosterone in men.

In addition to obesity, fatty liver is leading to low sperm count and poor sperm quality.

Studies show that sperm count in Indian men has dropped sharply over the last few decades, which is a growing concern. Doctors stated that "liver problems can also increase body stress, which further damages sperm health".

How To Prevent?

Fortunately, the progression of fatty liver disease can be stopped if people lose weight early in the course of the disease and adopt healthy eating habits and exercise regularly, said Dr. Vikas Jindal, Consultant, Dept of Gastroenterology at the CK Birla Hospital, Delhi

Further, the doctors stated that although liver disease is becoming a common problem, the worrying part is that people realize it very late.

They recommended:

• a liver health evaluation once a year, especially at-risk people like those with obesity, diabetes, altered liver parameters in blood test, fatty liver, hepatitis, or cirrhosis in family members.”

• Liver health and overall metabolic health must also be checked early in fertility treatment.

• Make simple lifestyle changes like healthy food, regular exercise, and weight control.

Cancer is often feared as a silent disease, but in many cases, the body does give early warning signs. The challenge is that these signals are either ignored, misunderstood, or detected too late.

A large number of cancer cases are diagnosed at advanced stages—not because symptoms were absent, but because they were overlooked or diagnosis was delayed.

Understanding the early signs and the reasons behind delayed detection can help save lives.

Speaking to HealthandMe, Dr Siddharth Sahai, Director & Unit Head - Medical Oncology, Max Super Speciality Hospital, Dwarka, shared seven signs of cancer that should not be neglected.

1. Unexplained weight loss

Losing weight without trying—especially more than 4–5 kilos in a short time—can be an early sign of cancers such as stomach, pancreas, or lung cancer.

2. Persistent fatigue

Feeling unusually tired despite adequate rest could signal underlying issues like blood cancers or colon cancer. This kind of fatigue does not improve with sleep.

3. Changes in bowel or bladder habits

Chronic constipation, diarrhea, blood in stool, or changes in urination patterns should not be ignored. These may point toward colorectal, bladder, or prostate cancer.

4. A lump or thickening in the body

Any new lump—especially in the breast, neck, or underarms—needs medical evaluation. Not all lumps are cancerous, but it’s important to rule it out early.

5. Persistent cough or hoarseness

A cough lasting more than 2–3 weeks, or voice changes, could be early signs of lung or throat cancer, especially in smokers.

6. Unusual bleeding or discharge

Bleeding between periods, after menopause, blood in urine, or unusual discharge can be warning signs of cancers such as cervical, uterine, or bladder cancer.

7. Non-healing sores or skin changes

Sores that do not heal, changes in moles, or new skin growths could indicate skin cancer or oral cancer (especially in tobacco users).

Also read: New Breast Cancer Guidelines Recommend Mammograms Every Two Years for Women

Why Cancer Diagnosis Often Gets Delayed

Dr Sahai also mentioned six common causes of delayed cancer diagnosis

Factors that contribute to late detection include:

1. Lack of awareness

Many people are not aware that these symptoms could be linked to cancer. They often dismiss them as minor issues like acidity, infection, or weakness.

2. Ignoring symptoms due to busy lifestyles

In both urban and rural settings, people tend to delay doctor visits due to work commitments, family responsibilities, or simply hoping the problem will resolve on its own.

3. Fear and denial

The fear of being diagnosed with cancer leads many individuals to avoid medical consultation. Denial becomes a major barrier, especially when symptoms are mild initially.

4. Limited access to healthcare in some areas

In smaller towns and rural regions, access to diagnostic facilities and specialists is still limited. This leads to delays in proper testing and referrals.

5. Financial constraints

Concerns about the cost of investigations and treatment often prevent timely medical attention. Many patients wait until symptoms worsen significantly.

6. Misdiagnosis or delayed referral

In some cases, early symptoms may mimic common illnesses. Without timely screening or specialist referral, diagnosis can be delayed.

The Importance Of Early Detection

Dr Sahai stressed that early detection significantly improves cancer outcomes. Most cancers, if identified in the initial stages, are treatable and even curable. The key lies in listening to your body and acting without delay.

Simple steps like regular health check-ups, cancer screening (such as mammography, Pap smear, or oral screening), and timely consultation can make a crucial difference.

Ignoring symptoms may seem convenient in the short term—but early action can save not just time, but life itself.