Can Damaged Sperm Lead To Pregnancy Complications?
Pregnancy is usually a time of happiness and hope, but it also brings in the unexpected. While there is much talk placed on the health of the expectant mother, the quality sperm coming from the father could dramatically change the outcome of pregnancy. The latest study suggests the risks of sperm DNA damage, even increasing the risks of complications preeclampsia and birth prematurity.
In a groundbreaking research study conducted by scientists from Lund University in Sweden, scientists discovered that DNA damage in sperm increases the risk almost up to double that of preeclampsia, this is a dangerous condition that may arise during pregnancies characterized by high blood pressure. In addition, DNA anomalies also increase the risk of premature births, and this further entails increased related adverse health outcomes for infants born through such conditions.
The next step would be to find out which group of men respond best to methods to prevent and treat sperm DNA damage, and to test these methods to prevent pregnancy complications," said Dr. Amelie Stenqvist, a lecturer at Lund University. According to this study, a significant message is put forward that paternal health assumes an important role in a successful pregnancy.
It focused its research on men, specifically whose sperm contained high levels of DNA fragmentation. For instance, some 20% to 30% of babies born via in vitro fertilization have fathers whose sperm contains damaged DNA. The DNA fragmentation index, an indicator to assess the percentage of DNA damage in sperm, indicated that when the percentage of sperm with a DFI above 30% was observed, they had almost no chance of resulting in natural conception. Even a DFI greater than 20% showed that the chances of getting pregnant are highly risky as the risk factor for pregnancy complications like preeclampsia is much high.
Uncommon Complications during Pregnancy
The most alarming complication during pregnancy is preeclampsia. It affects approximately 5% to 8% of pregnancies worldwide, which can cause fatal conditions for both the mother and the baby. The new findings now point out that sperm DNA damage may contribute to this condition, especially if it is due to assisted reproductive techniques such as IVF pregnancies. The research found that a DFI above 20% doubled the risk of preeclampsia from a mere 5% to almost 11% per.
Apart from causing preeclampsia, DNA fragmentation in sperm is also known to increase the risk for prematurity. Most premature babies experience respiratory, neurological, and developmental complications. Therefore, some degree of early intervention might be important for prospective parents.
Some of the rarer, though serious complications include placental abruption, which is the separation of the placenta from the uterine wall and intrauterine growth restriction, a condition by which the baby does not grow normally in the womb. These conditions though rare are potentially catastrophic both to the mother and the child. Results from this study may help in establishing the contribution of the father in such pregnancies.
Further study into sperm DNA damage is of urgent interest with regard to its consequences for pregnancy outcomes. According to Professor Aleksander Giwercman of Lund University in the field of Reproductive Medicine, "the analysis of DFI should be introduced as routine test in all fertility clinics.". "It could give answers to couples who are having difficulties with infertility, but our latest result also shows that DFI analysis can be a method to identify high-risk pregnancies, explained Giwercman.
For many, DNA fragmentation in sperm is often treatable. Common causes are oxidative stress, age, smoking, being obese, and infections. Addressing these elements will likely reduce DNA damage in sperm for men, raising the chances for a healthy pregnancy and baby.
Overall, the study importance should take into consideration paternal as well as maternal health towards reaching for a healthy pregnancy. Though DNA fragmentation in the sperm is supposed to increase the risk factors for complications in pregnancies, the advances into novel treatment approaches and tests are likely to alleviate complications in many families. Thus the findings of this study offer optimism and pave a pathway to more holistic fertility treatments in the future.
In most cases, a few careful habits are enough to prevent eye health from getting worse. (Photo credit: AI generated)
Summer can be difficult for the eyes, often in ways people do not immediately notice. Most of the attention during this season goes to drinking enough water, avoiding heat, and protecting the skin. Eye care usually comes much later, often only after discomfort begins. Long hours in the sun, dry surroundings, heat, and outdoor exposure can all leave the eyes feeling uneasy, especially over repeated days.
“During the summer season, we commonly see an increase in patients presenting with ocular surface discomfort, including dryness, itching, redness, burning sensation, and watering. Prolonged exposure to heat, ultraviolet radiation, dust, and air-conditioned environments can disturb the normal tear film and aggravate underlying allergic or dry eye conditions. In some cases, repeated eye rubbing and poor hygiene may also increase the risk of secondary irritation or infection. Timely preventive care and early attention to persistent symptoms are important to avoid worsening of these seasonal eye concerns,” says Dr Niteen Dedhia, Medical Director, Ojas Maxivision Super Specialty Eye Hospitals.
A common experience during summer is that the eyes simply do not feel as comfortable as they usually do. There may be a slight burning sensation, or the eyes may feel tired much earlier in the day, especially after being outdoors or spending hours in cooled indoor spaces. With the body losing fluids more quickly in hot weather, the eyes can also feel the effects. Many people do not immediately connect this discomfort to dehydration, but it plays a bigger role than expected. Added screen time indoors only makes this more noticeable.
During summer, the eyes are exposed to many small everyday irritants. Dust on the roads, dry wind, pollution, and even sweat can all add to the discomfort. In some people, this shows up as itching, mild redness, or watering that keeps returning. Rubbing the eyes may feel like the easiest response, but it often makes the irritation worse. If this continues for days, even a minor problem can start feeling quite troublesome.
Spending time in strong sunlight can be more exhausting for the eyes than most people realise. It is not just the brightness — by the end of the day, the eyes may feel heavy, watery, or unusually sensitive to light. Many people wear sunglasses, but not every pair is suitable for eye protection. Dark lenses may reduce glare, but that does not always mean they are blocking harmful rays. This is one reason discomfort can continue even when someone feels they have protected their eyes properly.
Managing summer eye discomfort does not require anything complicated. Staying well hydrated throughout the day helps more than most people expect. Using good-quality sunglasses, limiting time in the harsh afternoon sun, and simply rinsing the eyes after coming back from outside can ease a lot of irritation. Clean habits also matter in day-to-day care. Using your own towel, avoiding frequent hand contact with the eyes, and stepping away from screens occasionally can all help reduce strain and irritation.
Frequent heartburn is far from normal; doctors recommend getting it checked timely to rule out cancer. (Photo credit: AI generated)
Most people treat heartburn the way they treat a bad day: they reach for an antacid and move on. But for some patients, that familiar burning sensation is not just a digestive nuisance. It can be an early sign of something far more serious. A type of cancer called gastroesophageal junction (GEJ) adenocarcinoma develops quietly at the point where the food pipe meets the stomach, and it is frequently mistaken for routine acidity—until it is not.
Dr Ankit Jain, Senior Consultant, Medical Oncology, at Indraprastha Apollo Hospitals, in an interaction with Health and Me, spoke about the difference between cancer and heartburn symptoms.
The gastroesophageal junction is simply the meeting point between the oesophagus and the stomach. When stomach acid repeatedly irritates this area over months or years, the lining can begin to change at a cellular level. This change, known as Barrett’s oesophagus, is a precancerous condition that often develops silently in people with chronic acid reflux. If left undetected, it can progress to GEJ adenocarcinoma. The tricky part is that this cancer does not behave exactly like oesophageal cancer or stomach cancer. It sits between the two, and that makes both diagnosis and treatment more nuanced.
Heartburn is common across India, yet certain symptoms should not be brushed aside as routine acidity. If any of the following are present, a doctor’s visit should not be delayed:
These are not panic triggers; they are signals worth investigating promptly.
For patients over 40 with long-standing reflux, obesity, a smoking history, or a family history of upper digestive cancers, a baseline endoscopy is a reasonable and potentially life-saving step. GEJ adenocarcinoma caught early is far more treatable than the same cancer found at an advanced stage. The window for early detection exists, but it requires action before symptoms become severe. Persistent reflux deserves more than a repeat prescription. Sometimes, it deserves a closer look.
Credit: AI generated
India is taking significant steps to enhance its vaccination strategy, with a special focus on adults, particularly those aged 55 and above, said Dr. N K Arora, Member of the National Technical Advisory Group on Immunisation in India (NTAGI), as part of the World Immunization Week.
NTAGI is the highest advisory body on immunization in the country, which consists of independent experts who provide recommendations on vaccines after reviewing data on disease burden, efficacy, and cost-effectiveness of vaccines.
In an exclusive interaction with HealthandMe, Dr. Arora shared that the country “is in the process of establishing priority pathogens and vaccines aimed at the adult population”.
This initiative will target those above the age of 55 or 60 to tackle infections that are particularly serious in older individuals, especially those living with chronic conditions like diabetes, hypertension, and cancer.
“The process has started. This year, we will be moving in that direction,” said Dr. Arora.
The expert lauded the introduction of the HPV vaccine for young girls. Dr. Arora highlighted the critical importance of this initiative, given India’s status as the country with the highest number of cervical cancer cases globally.
"Cervical cancer is preventable by the HPV vaccine, and we are now in the fortunate position of having a domestically manufactured vaccine," he explained.
The first round of vaccinations has already commenced, and Dr. Arora urged the media and public to dispel any misinformation surrounding the vaccine to ensure its success.
Further, the vaccine expert highlighted the potential introduction of an indigenous dengue vaccine, currently undergoing trials.
“The trials will take at least two and a half years, which means by the end of 28, we will have the results,” Dr. Arora said.
He emphasized the severity of dengue when it turns from a mild illness into a severe one, particularly among young adults.
The dengue vaccine, being developed indigenously, is expected to play a crucial role in protecting the 10-20 age group, who are most susceptible to severe dengue cases.
“We are waiting for the results of the trials, and once the vaccine is recommended by the NTAGI, the system will be ready to adopt it,” said Dr. Arora.
Dr. Arora stated that India, known as the pharmacy of the world, is playing a significant role in the global vaccine landscape.
“One feels very proud to be an Indian as every vaccine administered in India is made in India,” he said, noting that India also "provides two-thirds of the global vaccine supply".
This achievement positions India as a global leader in vaccine research and development, contributing substantially to global health initiatives.
"These initiatives are vital for the future of public health in India," Dr. Arora said.
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