Can Damaged Sperm Lead To Pregnancy Complications?
Pregnancy is usually a time of happiness and hope, but it also brings in the unexpected. While there is much talk placed on the health of the expectant mother, the quality sperm coming from the father could dramatically change the outcome of pregnancy. The latest study suggests the risks of sperm DNA damage, even increasing the risks of complications preeclampsia and birth prematurity.
In a groundbreaking research study conducted by scientists from Lund University in Sweden, scientists discovered that DNA damage in sperm increases the risk almost up to double that of preeclampsia, this is a dangerous condition that may arise during pregnancies characterized by high blood pressure. In addition, DNA anomalies also increase the risk of premature births, and this further entails increased related adverse health outcomes for infants born through such conditions.
The next step would be to find out which group of men respond best to methods to prevent and treat sperm DNA damage, and to test these methods to prevent pregnancy complications," said Dr. Amelie Stenqvist, a lecturer at Lund University. According to this study, a significant message is put forward that paternal health assumes an important role in a successful pregnancy.
It focused its research on men, specifically whose sperm contained high levels of DNA fragmentation. For instance, some 20% to 30% of babies born via in vitro fertilization have fathers whose sperm contains damaged DNA. The DNA fragmentation index, an indicator to assess the percentage of DNA damage in sperm, indicated that when the percentage of sperm with a DFI above 30% was observed, they had almost no chance of resulting in natural conception. Even a DFI greater than 20% showed that the chances of getting pregnant are highly risky as the risk factor for pregnancy complications like preeclampsia is much high.
Uncommon Complications during Pregnancy
The most alarming complication during pregnancy is preeclampsia. It affects approximately 5% to 8% of pregnancies worldwide, which can cause fatal conditions for both the mother and the baby. The new findings now point out that sperm DNA damage may contribute to this condition, especially if it is due to assisted reproductive techniques such as IVF pregnancies. The research found that a DFI above 20% doubled the risk of preeclampsia from a mere 5% to almost 11% per.
Apart from causing preeclampsia, DNA fragmentation in sperm is also known to increase the risk for prematurity. Most premature babies experience respiratory, neurological, and developmental complications. Therefore, some degree of early intervention might be important for prospective parents.
Some of the rarer, though serious complications include placental abruption, which is the separation of the placenta from the uterine wall and intrauterine growth restriction, a condition by which the baby does not grow normally in the womb. These conditions though rare are potentially catastrophic both to the mother and the child. Results from this study may help in establishing the contribution of the father in such pregnancies.
Further study into sperm DNA damage is of urgent interest with regard to its consequences for pregnancy outcomes. According to Professor Aleksander Giwercman of Lund University in the field of Reproductive Medicine, "the analysis of DFI should be introduced as routine test in all fertility clinics.". "It could give answers to couples who are having difficulties with infertility, but our latest result also shows that DFI analysis can be a method to identify high-risk pregnancies, explained Giwercman.
For many, DNA fragmentation in sperm is often treatable. Common causes are oxidative stress, age, smoking, being obese, and infections. Addressing these elements will likely reduce DNA damage in sperm for men, raising the chances for a healthy pregnancy and baby.
Overall, the study importance should take into consideration paternal as well as maternal health towards reaching for a healthy pregnancy. Though DNA fragmentation in the sperm is supposed to increase the risk factors for complications in pregnancies, the advances into novel treatment approaches and tests are likely to alleviate complications in many families. Thus the findings of this study offer optimism and pave a pathway to more holistic fertility treatments in the future.
Credit: AI-generated image
After the social media trend of ‘ferritin face’ had everyone scrutinising their face for pale skin, dark circles and sluggish features due to low iron levels, attention is now shifting to hair. Described as ‘ferritin hair’, social media users have been attributing symptoms like unusual hair shedding, thinning and brittle strands to the body’s low iron stores.
The trend is not just a fluke. There is a medical basis for recognising iron deficiency in people facing hair loss. However, ‘ferritin hair’ is not a formal medical diagnosis. Hair loss can be due to several reasons, including hormonal changes, stress, thyroid disorders, nutritional deficiencies and genetic hair-loss conditions.
So is there a connection between ferritin and hair health and which signs should prompt someone to seek medical advice?
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Ferritin is a protein that stores iron in the body and releases it when needed. A blood ferritin test helps assess the body's iron reserves. Iron is essential for several functions, including the production of haemoglobin, which carries oxygen in the blood.
When iron stores are exhausted, the body prioritises essential functions over those that are not absolutely necessary for survival. Hair growth may be affected in some people, contributing to increased shedding.
A 2023 clinical review published in Cutis noted that measuring serum ferritin can be useful while evaluating people with diffuse hair loss, especially to identify underlying iron deficiency.
A 2026 study published in Cureus reported that low serum ferritin and telogen effluvium in women may be connected.
A separate systematic review published in 2026 also found lower ferritin levels among people with telogen effluvium.
The European Food Safety Authority has also observed a cause-and-effect relationship between iron intake and the maintenance of normal hair growth.
Also read: Ditching Dairy For Oat, Almond Milk? Your Body Could Miss Out On These 4 Essential Nutrients
Hair shedding: One possible sign is diffuse hair shedding, in which more hair than usual falls from across the scalp rather than from one specific area. This can occur due to a condition called telogen effluvium, in which more hair follicles than usual enter the resting phase of the hair-growth cycle.
Hair thinning: Constant shedding can make the hair appear less dense over time. Some people may notice a wider-looking parting or thinner volume.
Dry or brittle hair: Iron deficiency may cause dry, brittle hair. However, hair texture can also be affected by heat styling, chemical treatments and other nutritional factors.
Other symptoms: Hair shedding may occur with other signs of iron deficiency like fatigue, weakness, poor concentration, breathlessness, palpitations or pale skin.
Iron deficiency can develop when the body loses more iron than it absorbs and does not receive enough through diet. Heavy menstrual bleeding and pregnancy are common reasons for iron deficiency. Other possible causes include:
Credit: AI-generated image
Delhi’s air pollution has worsened even before the onset of peak winter. This has raised concerns about development and health of children who are constantly exposed to high levels of fine particulate matter (PM2.5).
While the immediate effects of polluted air like coughing, wheezing and breathing difficulties are known, research says that long-term exposure can also impact children’s developing brains, including effects on their memory, attention, IQ and ability to learn.
On November 12, Delhi's air quality got listed under 'very poor' category. Stations like IIT Delhi and Delhi IITM recorded an AQI of 416, while NSUT Jaffarpur and Delhi DPCC recorded 404. Anand Vihar station recorded 319 while DTU Delhi stated 372.
A new analysis by the Centre for Science and Environment (CSE), released recently, found that Delhi’s average PM2.5 concentration during the week preceding Diwali stood at 236 micrograms per cubic metre (µg/m³), the highest in the last three years. This was 97% higher than the 120 µg/m³ recorded in 2025 and 32% above the 179 µg/m³ recorded in 2024.
The analysis also found that pollution levels during the early winter period were higher this year than in 2025. Vehicular emissions and pollution from neighbouring NCR districts were among the major contributors. The findings suggest that firecracker smoke from Diwali aggravated an already high pollution burden.
Delhi’s pollution crisis is not only threatening people’s lungs and cardiovascular health, it is also posing significant risks to children’s brain health. Could breathing polluted air affect how well children concentrate, recall information and learn at school?
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PM2.5 refers to fine particulate matter with a diameter of 2.5 micrometres or smaller. These particles are small enough to travel deep into the respiratory system, fueling inflammation and oxidative stress. Not just lungs, their effects may reach children’s nervous systems.
Dr Sushil Singla, Director, Paediatrics, Sarvodaya Hospital, Sector 8, Faridabad told HealthandMe, “Exposure to PM2.5 (fine particulate matter) can affect children's cognitive development, including memory, attention span and learning abilities. These tiny particles can penetrate deep into the lungs and may trigger inflammation and oxidative stress, which can have wider effects on the developing brain. Children are particularly vulnerable because their brains are still developing and they inhale more air relative to their body weight than adults.”
The developing brain goes through significant changes throughout childhood. Processes involved in learning, memory, attention and executive function continue to evolve during these years. Exposure to environmental pollutants during fragile developmental periods is therefore a huge concern.
Also read: Delhi Air Pollution: PM2.5 Exposure May Raise Type 2 Diabetes Risk By 16%, Study Finds
Difficulties in paying attention, memorising and processing complex information can make it harder for children to follow lessons in the classroom.
“Prolonged exposure to high levels of air pollution has been associated with difficulties in concentration, attention, information processing and memory. This may also affect a child's learning abilities and academic performance over time. Although the extent of the impact varies depending on the duration and intensity of exposure, parents should take preventive measures,” says Dr Singla.
Several studies suggest that air pollution exposure may be associated with poorer cognitive outcomes in children.
A review and meta-analysis published in Environmental Health in 2024 examined six studies involving 4,860 children across North America, Europe and Asia. It found a statistically significant association between higher PM2.5 exposure and lower IQ scores. The researchers reported that every 1 µg/m³ increase in PM2.5 was associated with a 0.27-point decrease in full-scale IQ.
A 2022 review of 86 studies also found evidence between particulate matter exposure and poorer executive function in children, specifically working memory. Executive function refers to a set of mental skills that help children plan, focus attention, remember instructions and manage multiple tasks.
Recent research based on data from the US Adolescent Brain Cognitive Development (ABCD) study also showed that PM2.5 exposure was linked with smaller hippocampal volumes and lower working-memory in young people.
The hippocampus is a brain region involved in learning and memory. The researchers suggested that exposure during both prenatal development and late childhood could affect brain structure and function.
While individual precautions cannot eliminate the pollution burden, they can help reduce exposure. Dr Singla advises parents to monitor AQI levels, limit outdoor activities during peak pollution hours and ensure adequate indoor ventilation. Other measures include:
Credit: X
Former US President Joe Biden has shared an update on his battle with stage 4 prostate cancer, saying the disease has sometimes slowed him down but has not stopped him.
In a post on X, ahead of the November 17 release of his memoir, PROMISE ME, AMERICA, Biden revealed that he was diagnosed with prostate cancer while writing the book.
“Some days are better than others. It hasn't stopped me. But sometimes it slows me down,” he wrote, adding that he would be unable to participate in as many book-related conversations as he had hoped.
Biden said his doctors were encouraged by his response to treatment. He also thanked people for their prayers and wishes, saying their support meant a great deal to him, Jill and their family.
Biden also discussed his cancer diagnosis, treatment and its impact on his life in an interview with People, alongside his wife, former First Lady Jill Biden.
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Biden addressed speculation about when he learnt about his diagnosis, saying, “We let the public know when I found out.”
He said he initially experienced recurring pain, prompting Jill to question why men in their 70s were not routinely tested. Subsequent tests revealed that his prostate cancer had metastasised to the bone.
Biden also said he would have stepped down from the presidency had he known his discomfort was caused by cancer, People reported.
“If I had known that I was feeling lousy because I had cancer, I would have resigned,” he said, adding that he did not believe an 80-year-old man with cancer should be running for president.
The diagnosis changed the couple's plans for life after the White House, including travelling.
“Because of that metastasis, he will always have cancer,” Jill said. “It changes your life, it changes your perspective about life. So now we're on a new journey.”
Biden said he remained hopeful and was feeling good. He takes eight pills a day and has undergone two tests to check whether the cancer has spread further. He said the results indicated that it had not.
“I still have all my faculties. I still have my physical faculties as well. So we're hopeful,” he said.
Meanwhile, Jill described the emotional and physical demands of caring for her husband, saying it was different from looking after her parents or in-laws.
“It's just a lot different, I think, when it's your spouse because of the difference in the relationship,” she said.
Her daily routine now includes ensuring Biden eats well, exercises and takes his medication, as well as communicating with his doctors.
“I have seen how hard it is, how really emotionally hard it is, physically hard to go through each day,” she said.
The couple also discussed their family life and time with their grandchildren as they approach their 50th wedding anniversary.
Prostate cancer develops in the prostate, a gland found only in males, located below the urinary bladder and in front of the rectum.
Nearly all prostate cancers develop from glandular cells and are classified as adenocarcinomas.
In 2020, an estimated 1.4 million new cases and 370,000 deaths from prostate cancer were reported worldwide. It was the most frequently diagnosed cancer among men in 112 countries and the leading cause of cancer deaths among men in 48 countries.
According to the US Centers for Disease Control and Prevention (CDC), 255,395 new prostate cancer cases were reported in the US in 2022, making it the most commonly diagnosed cancer among American men that year.
Symptoms may include:
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