Can Damaged Sperm Lead To Pregnancy Complications? Study Highlights Uncommon Issues

Updated Oct 17, 2024 | 02:00 AM IST

SummaryDamaged sperm DNA increases the risk of complications such as preeclampsia and premature birth, even doubling it, according to a new study. These findings could make a difference in the execution of fertility treatments and delivery outcomes.
Can Damaged Sperm Lead To Pregnancy Complications?`

Can Damaged Sperm Lead To Pregnancy Complications?

Pregnancy is usually a time of happiness and hope, but it also brings in the unexpected. While there is much talk placed on the health of the expectant mother, the quality sperm coming from the father could dramatically change the outcome of pregnancy. The latest study suggests the risks of sperm DNA damage, even increasing the risks of complications preeclampsia and birth prematurity.

In a groundbreaking research study conducted by scientists from Lund University in Sweden, scientists discovered that DNA damage in sperm increases the risk almost up to double that of preeclampsia, this is a dangerous condition that may arise during pregnancies characterized by high blood pressure. In addition, DNA anomalies also increase the risk of premature births, and this further entails increased related adverse health outcomes for infants born through such conditions.

The next step would be to find out which group of men respond best to methods to prevent and treat sperm DNA damage, and to test these methods to prevent pregnancy complications," said Dr. Amelie Stenqvist, a lecturer at Lund University. According to this study, a significant message is put forward that paternal health assumes an important role in a successful pregnancy.

It focused its research on men, specifically whose sperm contained high levels of DNA fragmentation. For instance, some 20% to 30% of babies born via in vitro fertilization have fathers whose sperm contains damaged DNA. The DNA fragmentation index, an indicator to assess the percentage of DNA damage in sperm, indicated that when the percentage of sperm with a DFI above 30% was observed, they had almost no chance of resulting in natural conception. Even a DFI greater than 20% showed that the chances of getting pregnant are highly risky as the risk factor for pregnancy complications like preeclampsia is much high.

Uncommon Complications during Pregnancy

The most alarming complication during pregnancy is preeclampsia. It affects approximately 5% to 8% of pregnancies worldwide, which can cause fatal conditions for both the mother and the baby. The new findings now point out that sperm DNA damage may contribute to this condition, especially if it is due to assisted reproductive techniques such as IVF pregnancies. The research found that a DFI above 20% doubled the risk of preeclampsia from a mere 5% to almost 11% per.

Apart from causing preeclampsia, DNA fragmentation in sperm is also known to increase the risk for prematurity. Most premature babies experience respiratory, neurological, and developmental complications. Therefore, some degree of early intervention might be important for prospective parents.

Some of the rarer, though serious complications include placental abruption, which is the separation of the placenta from the uterine wall and intrauterine growth restriction, a condition by which the baby does not grow normally in the womb. These conditions though rare are potentially catastrophic both to the mother and the child. Results from this study may help in establishing the contribution of the father in such pregnancies.

Further study into sperm DNA damage is of urgent interest with regard to its consequences for pregnancy outcomes. According to Professor Aleksander Giwercman of Lund University in the field of Reproductive Medicine, "the analysis of DFI should be introduced as routine test in all fertility clinics.". "It could give answers to couples who are having difficulties with infertility, but our latest result also shows that DFI analysis can be a method to identify high-risk pregnancies, explained Giwercman.

For many, DNA fragmentation in sperm is often treatable. Common causes are oxidative stress, age, smoking, being obese, and infections. Addressing these elements will likely reduce DNA damage in sperm for men, raising the chances for a healthy pregnancy and baby.

Overall, the study importance should take into consideration paternal as well as maternal health towards reaching for a healthy pregnancy. Though DNA fragmentation in the sperm is supposed to increase the risk factors for complications in pregnancies, the advances into novel treatment approaches and tests are likely to alleviate complications in many families. Thus the findings of this study offer optimism and pave a pathway to more holistic fertility treatments in the future.

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This Common Vitamin Deficiency Can Look Like Dementia, Doctors Warn

Updated Jan 13, 2026 | 12:00 AM IST

SummaryVitamin B12 deficiency can cause memory loss and other symptoms that mimic dementia. Experts and the NHS explain the warning signs, risks, treatment options, and foods rich in B12.
vitamin b12 deficiency

Credits: Canva

People troubled by increasing forgetfulness are being advised to have their vitamin levels checked, as a shortage of one essential nutrient can cause symptoms that closely resemble dementia. According to the NHS, a deficiency in a key vitamin may lead to neurological issues that affect the nervous system, including problems with memory.

As per Mirror, Dr Eric Berg, DC, has also drawn attention to what he calls the “leading vitamin deficiency that mimics dementia,” identifying vitamin B12 as a major concern. Adequate levels of this nutrient are vital because it helps form red blood cells that carry oxygen through the body, supports DNA production and regulation, and converts food into usable energy.

Dr Berg, well known for promoting healthy ketosis and intermittent fasting, is the author of the bestselling book The Healthy Keto Plan and runs Dr Berg Nutritionals. He has since moved away from clinical practice to focus on sharing health information through online platforms.

Why Is Vitamin B12 Important?

Vitamin B12 is essential for the healthy functioning of the central nervous system and plays a key role in maintaining clear thinking and memory. When levels drop, people may experience weakness, numbness, difficulty walking, nausea, unintended weight loss, irritability, extreme tiredness, and a fast or irregular heartbeat.

Bones, hair, skin, and nails may also suffer. Dr Berg explains: “Vitamin B12 is essential for normal brain function. Without it, symptoms similar to dementia can develop. This vitamin is mainly found in animal-based foods, although some microbes can produce it. Low intake of animal products is the most common reason for vitamin B12 deficiency.”

Research suggests that low B12 levels can impair nerve function and may contribute to conditions such as dementia, peripheral neuropathy, or subacute combined degeneration. A deficiency can also interfere with DNA synthesis and cause homocysteine levels to rise.

What Does The NHS Say?

On its official website, the NHS states: “Most cases of vitamin B12 or folate deficiency can be treated easily and effectively, so complications are uncommon. However, complications may sometimes occur, particularly if the deficiency has been present for a long time. If neurological problems develop, they can occasionally be permanent.”

The NHS explains that a lack of vitamin B12 may lead to neurological symptoms such as:

  • vision problems
  • memory loss
  • pins and needles
  • loss of physical coordination (ataxia), which can affect speech or walking
  • damage to parts of the nervous system (peripheral neuropathy), especially in the legs

A study published in 2020 found a “clear association between low vitamin B12 levels and progressive cognitive impairment.” Researchers added that more large-scale studies are needed to confirm these findings and to see whether correcting the deficiency can slow cognitive decline.

More than one in ten older adults are estimated to have low vitamin B12 levels. In addition to memory problems, a deficiency may cause other neurological and psychological symptoms, including:

  • confusion
  • difficulty with thinking and reasoning
  • tingling or numbness in the hands and feet
  • poor balance and coordination
  • fatigue
  • weakness
  • vision disturbances
  • peripheral neuropathy affecting the nervous system
  • depression, anxiety, paranoia, and delusions
  • incontinence
  • loss of taste and smell

Can A Vitamin B12 Deficiency Be Treated?

If a vitamin B12 deficiency is diagnosed, treatment usually involves high-dose supplementation, either through injections or oral supplements. GPs may arrange regular blood tests to monitor B12 levels over time.

As per The Mirror, the longer the deficiency goes untreated, the higher the risk of permanent damage. That said, it is often reversible, with many people noticing marked improvement within three to six months. Other signs of vitamin B12 deficiency may include:

  • numbness, tingling, and pins and needles in the arms and legs
  • pale skin
  • unsteady walking or balance problems
  • a rapid heartbeat
  • shortness of breath
  • a swollen tongue
Low levels of stomach acid, known as hydrochloric acid (HCL), can also contribute to vitamin B12 deficiency, Dr Berg notes. He explains: “Your digestive system needs HCL to properly break down and absorb many vitamins and minerals.

“As we get older, HCL levels naturally decline. They can also drop if you take antacids or medications like Metformin. Interestingly, acid reflux can actually be a sign of low HCL, and antacids may worsen the problem. Betaine hydrochloride is one way to support normal stomach acidity.”

What Else Is Worth Being Aware Of?

Deficiencies in other nutrients may also cause symptoms that resemble dementia. Dr Berg highlights vitamin B1, which is often linked to high sugar and carbohydrate intake. Zinc deficiency, sometimes related to phytic acid found in grains, and low vitamin D levels due to limited sun exposure, may also play a role. “Nutrient deficiencies can shrink the hippocampus, which is linked to Alzheimer’s disease,” Dr Berg said.

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Have Flu Symptoms? NHS Shares Four Steps You Should Follow To Recover

Updated Jan 12, 2026 | 08:00 PM IST

SummaryNHS shares important advice for managing flu symptoms, including simple steps to support recovery and guidance on when to seek medical care.
influenza flu symptoms

Credits: Canva

The NHS has released fresh guidance on how to manage flu symptoms, setting out four simple steps that could help people recover faster. Influenza, commonly known as flu, is a highly contagious viral illness that affects the respiratory system, including the nose, throat, and lungs. It is marked by a sudden onset of fever, muscle aches, headaches, a persistent dry cough, and extreme tiredness, making it far more serious than the common cold.

Recent data from NHS England shows that in the first week of January, an average of 2,924 hospital beds across England were taken up by patients with flu. This figure reflects a nine per cent increase compared with the previous week.

With flu cases continuing to climb, the NHS has shared several important steps that people can follow to help support a quicker recovery.

NHS Shares Four Steps To Tackle Flu Symptoms 2026

In a recent update, NHS England warned that social gatherings during Christmas and New Year may have led to a resurgence of winter illnesses. NHS national medical director Professor Meghana Pandit said: “It is clear that the pressure on the NHS this winter is far from easing, with hospitals once again seeing a rise in patients admitted with flu and other respiratory viruses last week.

“The colder weather is also bringing more vulnerable patients to A&E with breathing difficulties, along with an increase in injuries caused by slips and falls in icy conditions, making this an exceptionally demanding period.”

According to the Mirror, she added: “Staff continue to work extremely hard, with teams across the country doing everything possible to ensure patients receive the care they need. It remains important for people to seek care as usual, and there are still many opportunities to get vaccinated and protect yourself against flu.”

Flu Symptoms 2026

The NHS says flu symptoms tend to appear suddenly and may include:

  • A high temperature that comes on quickly
  • Aches and pains throughout the body
  • Feeling very tired or exhausted
  • A dry, persistent cough
  • A sore throat
  • Headaches
  • Trouble sleeping
  • Loss of appetite
  • Diarrhoea or stomach pain
  • Feeling sick or being sick

Children may experience similar symptoms, but they can also have earaches and may appear more tired or less active than usual.

Flu Symptoms 2026: NHS Advice

The NHS states: “If you have flu, there are steps you can take to help yourself recover more quickly.”

  • Rest and get plenty of sleep
  • Keep yourself warm
  • Use paracetamol or ibuprofen to reduce fever and ease aches and pains
  • Drink plenty of fluids to prevent dehydration, aiming for urine that is pale yellow or clear

Flu Symptoms 2026: When To Seek Help?

You should contact NHS 111 or arrange an urgent GP appointment if you or your child have flu symptoms and:

  • You are concerned about your baby’s or child’s condition
  • You are aged 65 or over
  • You are pregnant
  • You have a long-term health condition, such as diabetes or a problem affecting the heart, lungs, kidneys, brain, or nerves
  • You have a weakened immune system, for example due to chemotherapy or HIV
  • Your symptoms have not improved after seven days
  • You develop sudden chest pain
  • You have trouble breathing
  • You begin coughing up large amounts of blood

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Inhaled Insulin: How Does This Needle-Free Option Work For People With Diabetes?

Updated Jan 12, 2026 | 06:20 PM IST

SummaryInhaled insulin is a needle-free option for diabetes care now launched in India. Here’s how it works, who it’s for, and what doctors say about its safety and use.
inhaled insulin

Credits: Afrezza

Cipla, a global name in inhalation therapies, has announced the launch of Afrezza, the world’s only rapid-acting inhaled insulin, in India. The drug is approved for adults with type 1 and type 2 diabetes to help manage high blood sugar levels and represents a notable change in how insulin can be delivered in a country facing a growing diabetes crisis.

For many patients, injecting insulin during long workdays or in public spaces can be uncomfortable or inconvenient. While insulin injections are widely used, awareness around inhaled insulin remains limited. Below, we explain how inhaled insulin works and what it means for people living with diabetes.

What Is Inhaled Insulin?

Inhaled insulin is a fast-acting form of insulin that is taken as a fine powder through an inhaler. Instead of being injected, it is breathed into the lungs, where it is quickly absorbed into the bloodstream to manage blood sugar spikes that occur after meals. This makes it a needle-free option for adults with type 1 or type 2 diabetes.

It begins working very rapidly, often just before or at the start of a meal, and exits the body sooner than injectable insulin. Because of this, it may lower the risk of insulin stacking and offers greater flexibility around mealtimes. Afrezza is currently the main FDA-approved inhaled insulin available.

How To Use Inhaled Insulin?

Unlike traditional insulin injections given under the skin, inhaled insulin is absorbed through the lining of the lungs, which allows it to enter the bloodstream quickly. “It functions like fast-acting insulin but starts acting sooner and also clears the body faster than conventional insulin,” said Dr Pranav Ghody, consultant endocrinologist and diabetologist at Wockhardt Hospitals, Mumbai Central, speaking to The Indian Express.

The insulin comes as a dry powder and is taken using a small, discreet inhaler with single-use cartridges available in 4, 8, and 12-unit doses. It has been approved by the FDA for adults with type 1 and type 2 diabetes to help control blood sugar rises after meals. “Its absorption into the bloodstream is faster than injectable rapid-acting insulins such as lispro or aspart,” said Dr Hetashvi Gondaliya, as reported by The Indian Express.

How Does Inhaled Insulin Work For Diabetic People?

Before starting inhaled insulin, patients are required to undergo lung function tests. The insulin itself is identical to the insulin used in injections. What differs is the way it enters the body.

In simple terms, the insulin is not new, only the method of delivery is. Once inhaled, it is absorbed through the lungs, passes into the bloodstream, and helps control the rise in blood sugar levels that happens after eating.

Is Inhaled Insulin Better Than Injectable Insulin?

Inhaled insulin is not necessarily better for everyone, but it offers an alternative to injections. It works faster to control post-meal blood sugar levels and may appeal to people who dislike needles. However, it is less efficient than injected insulin, requires a specific inhaler, and is not suitable for all patients.

Studies show that blood sugar control is similar to injectable insulin, but inhaled insulin must still be used along with long-acting basal insulin. It is best viewed as an option rather than a replacement.

Is Inhaled Insulin Suitable For All Diabetic Patients?

According to the National Institutes of Health, inhaled insulin is not appropriate for everyone. It may be considered for adults with type 1 or type 2 diabetes who want a needle-free option or need rapid control of blood sugar after meals.

However, it is not recommended for people who smoke or have smoked in the past six months, or for those with lung conditions such as asthma, COPD, or bronchitis. It is also not approved for children or pregnant women. Lung health and ongoing insulin needs must be carefully evaluated before starting this treatment.

Always consult your doctor before switching to or starting inhaled insulin. Your healthcare provider can help determine whether it is safe and suitable for you based on your medical history and lung health.

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