This is the story of Joseph, a 28-year-old man who's made a very difficult choice. On December 2024, Joseph Awuah-Darko shared the difficult decision of choosing euthanasia on Instagram. He's not physically sick, but he's been battling a severe mental illness called bipolar disorder for many years. He's tried many treatments, but nothing has helped him feel better. He feels like the pain of his illness is too much to bear. He's shared his story publicly to help people understand what he's going through and to show how serious mental illness can be. Joseph shared a post that explained why he is making this decision, in the caption of the post he shared, “I am not saying that life (as a phenomenon) isn’t worth living. It ABSOLUTELY is. What I am saying is that the mental weight of MINE has become entirely unbearable.”

Joseph has bipolar disorder, which means his moods swing very high and very low. He's had this illness for a long time, and it makes his life very difficult. On his Instagram, he has shared his journey with bipolar, he explained that he tried many different medicines and therapies, but they haven't worked. He feels constant pain and suffering because of his illness. He's reached a point where he feels like he can't go on anymore. He's been open about his struggles on social media, hoping to raise awareness about mental health. He wants people to understand how much he suffers and why he's made this decision.

Euthanasia in the Netherlands

Government of the Netherlands explain that in the Netherlands, it's legal for a doctor to help someone end their life if they meet certain conditions. This is called euthanasia. Joseph has applied for this because he feels his mental illness is causing him unbearable suffering. There are rules and procedures that doctors must follow. They have to make sure the person understands their decision and that there are no other options. The process can take a long time, sometimes years. Joseph believes that having the option of a peaceful and dignified death is important. He wants to have control over how his life ends.

The Last Supper Project

When Joseph shared his decision, people had many different reactions. Some people understood and supported him. Others were sad and hoped he would change his mind. He even received some negative comments. But he also received many kind messages, including invitations to have dinner. This inspired him to start "The Last Supper Project," where he travels and shares meals with strangers. In the caption he explained, “‘The Last Supper Project’ is based on the Harvard Study of Adult Development which speaks to the importance of quality relationships and community as the greatest predictor for happiness. And I feel connecting this way around food as a great unifying vessel could be beautiful.”

The Last Supper Project is one of the longest studies, lasting for more than 80 years, done on adult development. In an Author Speaks edition of McKinsey & Company, the study’s director Robert Waldinger explained the study wanted to know what helps people have happy and healthy lives, even if they had problems when they were young. Most studies only looked at what goes wrong, but this one wanted to know what goes right. The study emphasizes that it is never too late for positive changes. People often believe they are too old or incapable of forming good relationships. They may think happiness is out of reach. However, the study has observed individuals who found happiness unexpectedly.

Joseph wants to connect with people and enjoy these moments while he waits for his euthanasia request to be approved. He sees these dinners as a way to find joy and connection in his final chapter. He still has bad days, but he finds comfort in these shared experiences.

Several recent studies suggest that older adults who receive the shingles vaccine may be less likely to develop dementia, a condition affecting more than 57 million people worldwide.

Shingles is a painful viral infection caused by the reactivation of the varicella-zoster virus (VZV), which can remain dormant after chickenpox and later trigger a blistering rash and severe nerve pain.

Shingrix Vaccine And Reduced Dementia Risk

A June 2026 study published in the Annals of Internal Medicine suggests that one in 17 dementia cases could potentially be prevented through shingles vaccination.

Researchers at Brown University found that older adults who received the recombinant shingles vaccine (Shingrix) after a stay in a skilled nursing facility had a 24% lower risk of being diagnosed with dementia over four years than those who were not vaccinated.

The study analyzed Medicare and health records from more than 500,000 adults aged 66 and older admitted to skilled nursing facilities. Researchers compared those who received at least one dose of Shingrix with those who remained unvaccinated.

“A lot of previous studies with similar results focused on an older vaccine,” said study author Kaley Hayes, an assistant professor at Brown University’s School of Public Health.

“This study looks at the newest vaccine only in an older, vulnerable adult population who were not up to date with shingles vaccination and are at a very clear clinical point in care: entering a skilled nursing facility.”

The findings add to growing evidence linking shingles vaccination with a lower risk of dementia.

Also read: How To Spot Leptospirosis, Dengue, Malaria During Monsoons? Early Symptoms Not To Neglect

How Does The Vaccine Protect The Brain?

Researchers believe the vaccine may help protect the brain by preventing shingles and the inflammation caused by the virus.

Shingles can cause a “war zone” of inflammation in the brain, said Dr. Jennifer Pauldurai, the medical director of the Inova Brain Health and Memory Disorders Program in Northern Virginia, NBC News reported.

It’s not that the shingles vaccine itself is a “magic pill,” Pauldurai said.

Rather, the vaccine guards against the disease, which is known to disrupt brain health.

Evidence from Wales, Australia, and Canada

The latest findings add to a growing body of international research.

A study involving more than 282,000 older adults in Wales, published in Nature in 2025, found shingles vaccination was associated with a 3.5% lower absolute risk of dementia over seven years.

Another study of more than 101,000 older adults in Australia, published in the Journal of the American Medical Association in 2025, found vaccine eligibility was associated with a 1.8% lower dementia risk over 7.4 years.

Similarly, a study involving more than 232,000 older adults in Canada, published in The Lancet Neurology in 2026, linked shingles vaccine eligibility to a 2% lower dementia risk over 5.5 years.

Read More: Sepsis: India Joins Global Trial To Screen Newborns For Deadly Drug-Resistant Infections

Shingles: Early Warning Signs

After a person recovers from chickenpox, the VZV virus remains dormant in nerve cells and can become active again years or even decades later, particularly when the immune system weakens.

Older adults and people with weakened immune systems are at the highest risk of developing shingles.

According to the NHS, shingles often starts with:

• Burning, tingling, itching, or pain on one side of the body
• Headache or feeling generally unwell
• A blistering rash that develops within a few days, most commonly on the chest or abdomen

When To See A Doctor

Seek prompt medical attention if:

• The rash appears on or near the eye
• The pain is severe or rapidly spreading
• You have a weakened immune system
• You are pregnant
• Symptoms are worsening quickly

From bone smashing to black market peptides, the modern push to “optimize” the male body increasingly runs through human endocrinology, often without a doctor anywhere in the loop.

A Trend That Outgrew Its Origins

Looksmaxxing began on incel forums that blamed romantic failure on fixed facial geometry. That ideology has since spread to TikTok and Instagram, stripped of some of its uglier language but keeping its core premise: a man’s body can and should be engineered, whatever the cost. What started as a fringe belief system now functions as mainstream influencer content with millions of followers.

Clinicians split the practice into softmaxing (sleep, skincare, fitness, mostly harmless) and hardmaxxing, which branches into two wings: mechanical (bone smashing, jaw implants, leg lengthening) and pharmaceutical (unsupervised testosterone, anabolic steroids, SARMs, and peptides marketed as growth hormone substitutes). The pharmaceutical wing is growing fastest, and it sits squarely in endocrinology’s territory.

What These Drugs Actually Do

The body regulates testosterone through a feedback loop running from the hypothalamus to the pituitary to the testes. Flood that system with outside testosterone or anabolic steroids, and it shuts down its own production, taking fertility down with it. SARMs were built to act on muscle and bone while sparing the prostate, but none are approved for human use, and the versions sold online are unregulated and inconsistently dosed. Peptides like ibutamoren (MK-677) stimulate the body’s own growth hormone release. The mechanism sounds gentler, but few have completed real clinical trials for the uses they are marketed for.

The Documented Harms

Anabolic steroids:

● Testicular atrophy and infertility from HPG axis suppression

● Gynecomastia, from testosterone converting to estrogen

● Hepatotoxicity, especially with oral forms

● Psychiatric effects at high doses, including mood instability

SARMs:

● Liver injury, including cholestatic jaundice in black market cases

● Dose-dependent suppression of natural testosterone production

● Elevated liver enzymes, reduced HDL cholesterol

Across the board:

● Elevated hematocrit, raising clotting risk if unmonitored

● Adrenal suppression and disruption of corticosteroid and DHEAS production: exogenous androgens interfere with the hypothalamic-pituitary-adrenal axis, blunting the adrenal gland’s output of cortisol and dehydroepiandrosterone sulphate (DHEAS). The result is impaired stress response, fatigue, and hormonal dysregulation that persists well after the substance is stopped.

● Elevated blood pressure and increased cardiac sympathetic drive: anabolic agents raise systolic pressure and heighten sympathetic nervous system activity in the heart, accelerating resting heart rate and increasing myocardial oxygen demand. Over time, this contributes to left ventricular hypertrophy and raises the risk of arrhythmia.

● Unreliable contents: labels rarely match what is actually in the product, and contamination or substitution is common enough that toxicology reports periodically turn up drugs users never intended to take.

The Mechanical Risks

Bone smashing has no basis in orthopedic science. Bone remodels under sustained load, not blunt trauma, which produces fractures, hematomas, and sometimes permanent damage. Cosmetic jaw implants and leg lengthening are legitimate procedures in the right clinical context, but carry the same surgical risks, infection, nerve damage, long recovery, without the medical justification that normally accompanies them.

The pharmaceutical track carries its own structural toll: supraphysiological androgen levels accelerate calcification in tendons and menisci, reducing their elasticity and load-bearing capacity. Meniscal and tendon calcinosis increases the risk of tears and joint instability, often in the absence of any acute injury. Athletes who stop using these compounds may find the damage is already done.

A related danger runs alongside both tracks. Some men adopt extreme dieting, dehydration, or fasting protocols purely to sharpen jaw and cheekbone definition before photos. The behavior carries the same physical risks as any restrictive eating disorder, yet it rarely gets recognized or treated as one, since it is framed online as discipline rather than disorder.

Why Now

Gallup polling found that roughly a quarter of young American men report frequent loneliness, a notably higher rate than young women. Online communities built around appearance fill that gap with something that looks like belonging, even though the content itself runs on comparison and self-criticism.

TikTok’s own data illustrate how fast the trend has moved: searches for bone smashing and related terms ran in the hundreds of thousands per day in early 2026 and climbed into the millions within a month, before the platform restricted the content. Marketing has kept pace too: one UK survey found nearly a third of 16 to 25-year-olds see SARM ads on social media weekly.

What Legitimate Treatment Looks Like

TRT for confirmed hypogonadism, diagnosed through repeat morning bloodwork and monitored over time, is genuinely effective medicine. That is a different undertaking entirely from a eugonadal man sourcing hormones or peptides online to chase a feeling, with no diagnosis and no monitoring. The same distinction applies to surgery: a qualified surgeon’s evaluation is not the same as a procedure booked off a forum recommendation.

The Bottom Line

None of this is an argument against fitness or grooming, and most softmaxxing is harmless. The danger lies in a narrower set of behaviors: fracturing healthy bone, importing unregulated hormones, chasing a standard that keeps moving regardless of what is achieved.

Endocrinologists studying this are not against masculinity or ambition about one’s appearance. They are arguing that hormonal systems deserve the same evidence-based caution as any other organ system, and that distinction matters more now that these behaviors are still treated as cultural curiosities rather than the clinical concerns they actually are. A blood test and a doctor’s judgment remain better tools than a forum thread and a vial of unknown origin.

The United Kingdom is facing constant heatwaves. So far, the nation has witnessed two heatwaves, while the natural temperature increases usually during late July and August, thus creating fear and the possibility of more and more temperature rises. As the country has been going through a weather roller-coaster since May, there was a huge area of high pressure, commonly explained as a 'heat dome'. This resulted in dry, very warm, and sunny weather in the island nation.

Notably, the temperature soared up to 35.1 °C in London during the month of May. The temperature in the UK has been on a rising trend over the past few years, and the first time it touches 40C in July 2022. And according to the experts at the Met Office, if global warming continues at its current pace, temperatures in the mid-forties could be a serious possibility for the UK by 2050.

The World Health Organization advises people to drink plenty of water, avoid going outdoors during the hottest hours of the day, wear loose and light-coloured clothing, and keep homes as cool as possible as temperatures continue to spike across many parts of the world.

Indians are used to living with intense summer heat, and over the years, people have developed simple yet effective ways to cope with it. Many prefer to finish outdoor work during the cooler hours of the morning or after sunset. Drinking plenty of water and traditional cooling beverages, seeking shade whenever possible, and keeping a close eye on elderly family members, young children, and people with existing health problems are all common practices during extended spells of extreme heat.

Also Read: Why Thousands Of Black Men In The UK Are Now Being Invited For Prostate Cancer Screening?

Hospitals Under Pressure Throughout Western Europe And Strict Restrictions

The worsening conditions have disrupted healthcare services, with media reports saying hospitals have had to postpone critical imaging scans after sensitive equipment overheated. Cities have also opened emergency cooling centers to protect vulnerable residents.

In Paris, authorities have announced temporary bans on public alcohol consumption and takeaway alcohol sales to ease pressure on hospitals. Public drinking will be prohibited from noon to 7 a.m. over the weekend, while takeaway alcohol sales will be banned between 6 p.m. and 7 a.m.

The extreme temperatures have also reached the sporting world. Formula 1's governing body, the FIA, has declared another "heat hazard" ahead of the Austrian Grand Prix weekend at Spielberg's Red Bull Ring, triggering additional measures to protect drivers, teams, and spectators.

The June 2026 heatwave has triggered red alerts across France, Spain, Italy, and the United Kingdom, and killed dozens of people.

How Does Heat Impact Health?

Health experts warn that prolonged exposure to extreme heat can have serious and sometimes fatal consequences, particularly for older adults and people with underlying medical conditions.

According to the WHO, extreme heat can overwhelm the body's ability to regulate temperature, increasing the risk of heat exhaustion and heatstroke. As the body works harder to cool itself, it places added strain on the heart and kidneys, potentially worsening chronic conditions such as cardiovascular, respiratory, mental health, and diabetes-related illnesses, and increasing the risk of acute kidney injury.