The winter season compels us to sit at one place, under the blanket, at the ease of warmth. But aren't we all aware of the dangers of a sedentary lifestyle? And when it is winter, it makes it more so stagnant. Not just that, but now a new study from the University of Iowa says that being a couch potato could lead to 19 chronic conditions. Among the 19 chronic conditions, obesity, diabetes, depression and heart diseases also made it to the list.

Research shows that among many diseases, increased blood pressure, high blood sugar, excess body fat around the waist, unhealthy cholesterol levels that leads to metabolic syndrome, cardiovascular disease and cancer are also there. This is why any extended sitting whether at desk, behind the wheel or the screen can be harmful.

How was the study conducted?

The team of researchers from various departments at the University of Iowa conducted a detailed study where they analyzed records from over 40,000 patients at a major Midwestern hospital system. In the records, they looked at the extensive physical inactivity of these patients and how it impacted their overall health.

The study and the detailed analysis is published in the journal Preventing Chronic Disease and studies.

As part of conducting the study, a 30-second exercise survey was conducted. Then, patients were also asked two questions: how many days per week they engaged in moderate to vigorous exercise and for how many minutes per session? On the basis of response, the patients were categorized into three groups:

• Inactive - 0 minutes per week
• Insufficiently active - 1-149 minutes per week
• Active - 150 minutes per week

As per Lucas Carr, associate professor in the Department of Health and Human Physiology and study's corresponding author, "This two-question survey typically takes fewer than 30 seconds for a patient to complete so it does not interfere with their visit. But it can tell us a whole lot about that patient's overall health."

What did the study find?

The study got 7,261 responses, and it found that around 60% of them met the recommended guidelines for exercising. These people met the 150 minutes or more minutes of moderate exercise per week. However, almost 36% exercised less than 150 minutes per week and 4% reported no physical activity.

The study also found that people experienced lower rates of depression. 15% of people who exercise for 150 minutes or more, or at least for some amount of time could experience depression, as compared to 26% of those who are inactive. Similarly, for obesity, the numbers are 12% versus 21% for obesity, 20% versus 35% for hypertension and the similar trend was seen in other diseases, and markers of good health, including lower resting pulse rates, and cholesterol profiles.

Patients with no physical activity carried a median of 2.16 chronic conditions, this number was 1.49 conditions in insufficiently active patients and dropped to 1.17 in active patients.

The 19 chronic conditions are:

• Obesity
• Live disease
• Psychoses
• Chronic Lung disease
• Neurological seizures
• Coagulopathy (blood clotting disorder)
• Depression
• Weight loss issues
• Uncontrolled hypertension (high blood pressure)
• Controlled hypertension
• Uncontrolled diabetes
• Anemia deficiency
• Neurological disorder affecting movement
• Peripheral vascular disease
• Auto Immune Disease
• Drug Abuse
• Hypothyroidism
• Congestive heart failure
• Vulvar disease (heart valve problem)

A woman experiencing abdominal discomfort went to her gynecologist for an ultrasound, only to discover something far more startling than a baby. The mom, who shares her story on TikTok under the handle @sandwitchbread, revealed her medical surprise in a video that has now amassed over 1.9 million views. She said she had been struggling with pain and unusual bleeding since giving birth to her two-year-old son and decided to see a gynecologist fearing she might be pregnant again.

During the ultrasound, she noticed something on the screen, but the doctor quickly reassured her it wasn’t a baby. “When my doctor came in to share the results,” the TikToker recalled, “she looked me in the eyes and told me I had a seven-centimeter cyst, about the size of a chicken egg, called a dermoid cyst.”

What Is A Dermoid Cyst?

A dermoid cyst is a pocket of tissue growth that can contain normal body tissues, sometimes including hair, fluid, teeth, or skin. While this TikToker’s cyst was in her uterus, dermoid cysts are most commonly found in the ovaries. They are generally harmless but often require surgical removal. According to the National Cancer Institute, dermoid cysts are present from birth but may not be detected until later in life. These benign tumors originate from embryonic cells that become “trapped” and develop into tissues in the wrong location. Teeth and hair are frequent components, and surgery is usually recommended if the cyst causes symptoms or complications.

Why Do Dermoid Cysts Have Hair and Teeth?

Dermoid cysts develop hair and teeth because they arise from trapped embryonic cells (ectoderm) that can grow into skin, hair follicles, sweat glands, and even teeth, instead of forming the tissues normally found in the ovary or skin. Essentially, they are benign tumors made up of mature but misplaced body tissues from the outer layer of the embryo, which normally forms skin and related structures.

Dermoid Cysts: Symptoms

Most ovarian dermoid cysts remain symptom-free unless complications occur. When symptoms do appear, the most common one reported is lower abdominal pain.

As the cyst enlarges, it can cause noticeable abdominal swelling and problems with the urinary or digestive system.

In more severe cases, individuals might also experience:

• Fever
• Intense abdominal pain
• Unusual vaginal bleeding
• Unexplained weight loss

The Office on Women’s Health notes that cysts on the ovaries can also cause:

• Pressure in the abdomen
• Bloating
• Abdominal swelling
• Pain in the lower abdomen

Dermoid Cysts: Possible Complications

Some potential complications include:

Rupturing of the cyst: Though rare, ovarian dermoid cysts can burst. If the cyst’s contents leak into the abdominal cavity, it may lead to chronic inflammation of the abdominal lining (peritonitis). In some cases, leakage into the intestines or rectum can result in the material being expelled through the anus.

Ovarian torsion: This occurs when the cyst twists the ligaments holding the ovary in place, which can cut off blood supply to the ovary and fallopian tube.

Infection: The risk of infection is around 1–4%. Severe infections may lead to cyst rupture.

Malignant transformation: Dermoid cysts are almost always benign, but in rare instances, they can become cancerous.

A new weight-loss drug often described as the “triple G” treatment because it mimics three hormones linked to hunger and metabolism has delivered striking results in fresh data shared Thursday by its developer, Eli Lilly. In a clinical study involving more than 400 people living with obesity and knee osteoarthritis, the experimental drug retatrutide led to an average weight reduction of 71 pounds, or close to 29% of total body weight, over a period of 16 months, according to figures released by the company. Participants who received retatrutide also reported a 76% drop in knee pain by the end of the study period, based on the same data. So is

What Is Retatrutide?

Retatrutide is an experimental weight-loss drug developed by Eli Lilly and is widely seen as a next-step advancement beyond current GLP-1-based medications such as semaglutide and tirzepatide. While semaglutide acts on a single hormone pathway and tirzepatide works on two, retatrutide targets three.

It activates GLP-1 and GIP, along with an added glucagon pathway, which is why it is sometimes informally referred to as a “GLP-3” drug. Researchers believe this third pathway could explain the greater weight-loss effects seen so far, although retatrutide remains under investigation and has not yet received FDA approval.

Why Is Retatrutide Trending?

Even without regulatory approval, retatrutide has gained attention among gym enthusiasts, fitness creators, and online weight-loss communities. On platforms like TikTok, where direct searches for #reta or #retatrutide are restricted, users often refer to it using coded terms such as “ratatouille.”

At the same time, the drug has been in the news due to growing concerns about counterfeit versions. Reports from the UK recently revealed that authorities seized more than £250,000 worth of fake weight-loss injection pens labelled as tirzepatide and retatrutide from a hidden factory in Northampton. These products are especially concerning because retatrutide is still in clinical trials and has not been approved for use anywhere in the world.

How Is Retatrutide Different Than Other Weight-Loss Drugs?

Retatrutide works by mimicking three hormones that play a role in appetite and metabolism: GLP-1, GIP, and glucagon. In contrast, most weight-loss drugs currently available target only one or two of these pathways. Ozempic and Wegovy, made by Novo Nordisk, copy the effects of GLP-1, a hormone that influences the brain, pancreas, stomach, liver, and muscles, according to the National Institutes of Health.

Mounjaro and Zepbound, on the other hand, act on both GLP-1 and GIP, a hormone involved in blood sugar regulation through insulin stimulation. Retatrutide’s added glucagon effect is key, as glucagon is known to support fat burning, even when the body is at rest. Ozempic and Mounjaro are approved by the FDA for treating Type 2 diabetes, while Wegovy and Zepbound are approved for people with overweight or obesity. As with any prescription drug, it is important for individuals to consult a healthcare professional to determine whether these treatments are appropriate for them.

When Is Retatrutide Expected To Be Available To Consumers?

There is currently no confirmed timeline for when retatrutide might become available by prescription. Its launch will depend on the FDA’s detailed evaluation of clinical trial data once it is formally submitted. Based on current expectations, approval is unlikely before late 2026 and could potentially extend into 2027 or even 2028.

The use of nicotine pouches is rising sharply across the UK, especially among young adults, recent research suggests. These small pouches sit between the lip and gum and release nicotine gradually into the body. Available in many flavours, they often include sweeteners and plant-based fibres. But are they truly a better option than smoking, or could nicotine pouches still pose health risks? We take a closer look below.

What Are Nicotine Pouches?

Nicotine pouches are small, tobacco-free sachets that contain nicotine powder along with flavourings and fillers. They are placed between the lip and gum, similar to snus, allowing nicotine to be absorbed without smoke, vapour, or spitting. Marketed as a discreet way to consume nicotine, they still deliver a highly addictive substance and expose users to certain chemicals. Health experts have raised concerns, particularly for young people, despite these products often being promoted as a “safer” choice than cigarettes.

Popular brands such as Zyn, On!, and Velo now dominate a fast-growing market, according to the CDC. Like vaping, they do not contain tobacco and are generally viewed as less harmful than smoking.

A recent study led by researchers at University College London (UCL) found that over the past five years, about 522,000 additional people in the UK have started using nicotine pouches, with usage rising from 0.1% to 1% of the adult population.

This has raised an important question: are nicotine pouches actually safer than smoking, and what is driving their sudden popularity?

Nicotine Pouches: Is Using Them Safer Than Smoking?

Speaking on *Mornings with Ridge and Frost*, lead study author Dr Harry Tattan-Birch from UCL’s Institute of Epidemiology and Health Care told Sky News that the risks linked to nicotine pouches are much lower than those associated with smoking. “There’s no tobacco and no combustion,” he explained. “And we know it’s the burning of tobacco that causes most smoking-related diseases.”

That said, Dr Tattan-Birch and his colleagues stressed that these products are not harmless and should never be accessible to children. The NHS notes that while nicotine itself does not cause serious diseases in the way tobacco does, young people’s developing brains and lungs are more vulnerable to its effects, and dependency can form quickly.

UCL research fellow Eve Taylor also told Sky News that nicotine pouches are “far less harmful than smoking,” but cautioned that they are still relatively new. Because of this, their long-term effects are not yet fully understood. “We can look at what’s in them to estimate potential risks,” she said. “They’re not risk-free. Users are still exposed to some toxic substances, even if the levels are much lower.”

Nicotine Pouches: Are Pouches Helping People Quit Smoking?

According to UCL’s findings, among participants surveyed between January 2022 and March 2025, 69% of nicotine pouch users were also using other nicotine products. More than half of them, 56%, were still smoking cigarettes. Around one in six users, or 16%, reported that they had never been regular smokers, suggesting the habit was not linked to quitting cigarettes.

As quoted by Sky News, Dr Tattan-Birch said the public health impact of nicotine pouches depends largely on who is using them. “If a young person who might otherwise smoke switches to pouches, that could reduce harm,” he said. “But if someone who wouldn’t have used nicotine at all starts using them, the risk of harm goes up.”

Researchers added that more studies are needed to understand whether nicotine pouches genuinely help people stop smoking in the long run.

Are Nicotine Patches Harmful For Health?

Nicotine patches are widely regarded as safer than smoking and are a well-established aid for quitting. They provide a steady dose of nicotine to reduce cravings without exposing users to tar or cancer-causing chemicals found in cigarettes. However, they are not completely without side effects. Common issues include skin irritation, headaches, and sleep disturbances. People with serious heart conditions or those who are pregnant are advised to speak with a doctor before using them, as nicotine can still affect heart rate and blood pressure, though far less dangerously than smoking, according to the CDC.