The winter season compels us to sit at one place, under the blanket, at the ease of warmth. But aren't we all aware of the dangers of a sedentary lifestyle? And when it is winter, it makes it more so stagnant. Not just that, but now a new study from the University of Iowa says that being a couch potato could lead to 19 chronic conditions. Among the 19 chronic conditions, obesity, diabetes, depression and heart diseases also made it to the list.

Research shows that among many diseases, increased blood pressure, high blood sugar, excess body fat around the waist, unhealthy cholesterol levels that leads to metabolic syndrome, cardiovascular disease and cancer are also there. This is why any extended sitting whether at desk, behind the wheel or the screen can be harmful.

How was the study conducted?

The team of researchers from various departments at the University of Iowa conducted a detailed study where they analyzed records from over 40,000 patients at a major Midwestern hospital system. In the records, they looked at the extensive physical inactivity of these patients and how it impacted their overall health.

The study and the detailed analysis is published in the journal Preventing Chronic Disease and studies.

As part of conducting the study, a 30-second exercise survey was conducted. Then, patients were also asked two questions: how many days per week they engaged in moderate to vigorous exercise and for how many minutes per session? On the basis of response, the patients were categorized into three groups:

• Inactive - 0 minutes per week
• Insufficiently active - 1-149 minutes per week
• Active - 150 minutes per week

As per Lucas Carr, associate professor in the Department of Health and Human Physiology and study's corresponding author, "This two-question survey typically takes fewer than 30 seconds for a patient to complete so it does not interfere with their visit. But it can tell us a whole lot about that patient's overall health."

What did the study find?

The study got 7,261 responses, and it found that around 60% of them met the recommended guidelines for exercising. These people met the 150 minutes or more minutes of moderate exercise per week. However, almost 36% exercised less than 150 minutes per week and 4% reported no physical activity.

The study also found that people experienced lower rates of depression. 15% of people who exercise for 150 minutes or more, or at least for some amount of time could experience depression, as compared to 26% of those who are inactive. Similarly, for obesity, the numbers are 12% versus 21% for obesity, 20% versus 35% for hypertension and the similar trend was seen in other diseases, and markers of good health, including lower resting pulse rates, and cholesterol profiles.

Patients with no physical activity carried a median of 2.16 chronic conditions, this number was 1.49 conditions in insufficiently active patients and dropped to 1.17 in active patients.

The 19 chronic conditions are:

• Obesity
• Live disease
• Psychoses
• Chronic Lung disease
• Neurological seizures
• Coagulopathy (blood clotting disorder)
• Depression
• Weight loss issues
• Uncontrolled hypertension (high blood pressure)
• Controlled hypertension
• Uncontrolled diabetes
• Anemia deficiency
• Neurological disorder affecting movement
• Peripheral vascular disease
• Auto Immune Disease
• Drug Abuse
• Hypothyroidism
• Congestive heart failure
• Vulvar disease (heart valve problem)

Lung cancer is among one of the most feared health condition known to man and detecting it early on can make a difference between life and death but now a new study has even claiming of a more promising detection option where the detection the disease will be possible even before it starts to grow in this way the potential patient will be able to stay through screening and possible medication far before the ailment starts to grow in their body.

A new study by Australia’s Walter and Eliza Hall Institute of Medical Research (WEHI) has identified a new blood signature that might detect cancer even before the disease develops. They are claiming that with this blood test, there is a chance that detection can be possible even 5 years before it actually occurs. The study was published in Cell.

The research was conducted with over 48,000 blood samples, and they identified a 14-protein signature that predicted lung cancer risk within five years and was validated across eight international datasets. Researchers made clear that the detection did not come from the tumor but from a different inflammatory lung environment that precedes cancer.

WEHI laboratory head Clare Weeden, a corresponding author on the paper, said: "The study could lead to more inclusive and effective screening approaches for people in Australia and across the world." She added, “In doing so, these findings bring us closer to a future where early intervention is possible, even before the cancer has a chance to develop.”

Also Read: Diphtheria Outbreak: Australia Reports First Death In A Decade

What Is Lung Cancer?

Lung Cancer is one of the most common and serious types of cancer. It is also the leading cause of cancer-related deaths worldwide, with approximately 2.5 million new cases and 1.8 million deaths reported in 2022. According to the American Cancer Society, lung cancer mainly occurs in older people. Most people diagnosed with lung cancer are 65 or older; a very small number of people diagnosed are younger than 45.

The Two Main Types Of Lung Cancers Are:

Non-small-cell lung cancer (NSCLC): This is the most common form, making up about 80–85% of all cases. NSCLC includes three subtypes:

• Squamous cell carcinoma
• Adenocarcinoma
• Large-cell carcinoma

Small-cell lung cancer (SCLC): Less common than NSCLC, this type tends to grow and spread more quickly.

Early Signs And Symptoms To Look Out For

Lung cancer symptoms can mimic less serious conditions, which is why they’re often dismissed or misdiagnosed. If you experience the following symptoms persistently, don’t ignore them—regardless of your age or smoking history:

• Chest pain or discomfort
• Unexplained shortness of breath
• Persistent cough or wheezing
• Shoulder, back, or rib pain
• Fatigue or sudden weight loss
• Blood in sputum (though not always present).

For many young and middle- aged adults, headaches or brief dizzy spells often feel routine — attributed to long work hours, stress, or poor sleep. Occasional blackouts or “spacing out” episodes may be brushed aside as fatigue or skipped meals.

What makes these symptoms particularly dangerous is that they are often mistaken for burnout, stress, migraines, or exhaustion — especially among younger working professionals. While most headaches are harmless, persistent neurological symptoms that disrupt daily life should never be ignored.

But there are neurological symptoms you should never ignore: sudden seizures, memory loss after brief collapse, repeated headaches, unexplained weakness, or changes in personality. These can sometimes point to an underlying brain disorder — and, in rare cases, to Glioblastoma, one of the most aggressive forms of brain cancer.

Glioblastoma (GBM) is one of the most aggressive and fast-growing forms of brain cancer in adults. It develops in the supportive tissue of the brain and can quickly affect memory, speech, movement, personality, and other neurological functions. Because the tumour tends to spread into nearby healthy brain tissue, complete surgical removal is often difficult, making timely diagnosis and treatment extremely important. While brain tumours are often associated with older adults, specialists are increasingly seeing younger individuals dismiss early warning signs as work-related fatigue, lack of sleep, stress, or lifestyle burnout. Delayed recognition can sometimes postpone critical medical intervention. In India, there are around 23,000 glioblastoma cases per day, considered higher incidence rates along with North America, Australia, Northern and Eastern Europe. Seizures and persistent headaches are often among the earliest symptoms that prompt medical investigation.

Recently, a 34-year-old woman presented to Apollo Hospitals, Bannerghatta with seizures and memory loss. Her first seizure occurred one morning at home — she collapsed briefly, with twisting of arms and legs, and woke with total memory loss of the episode. Like many young professionals struggling between work and personal commitments, she first considered the cause to be work-induced stress. The family did not suspect that these seemingly routine headaches and blackouts could indicate a serious neurological condition. Before that, she had minor headaches — the kind most people ignore. An MRI scan revealed brain swelling, and anti-seizure medication was prescribed. A second opinion at month’s end showed swelling reduction.

The turning point came in late, during a road trip, when she suffered three seizures in two hours. A burr hole biopsy of a right frontal lesion suggested a diffuse low-grade glioma. Subsequent evaluations at Apollo Hospitals upgraded the diagnosis to bifrontal Glioblastoma — a clinically challenging case due to its location. This is a clinically unusual case because most of the time, GBM is diagnosed with MRI with contrast, MR spectroscopy, and biopsy to confirm the type and grade of tumor. In this patient’s case, imaging revealed widespread bifrontal involvement — making conventional surgery high risk. Her care team opted for a non-surgical precision radiotherapy approach. She had 25 high precision image guided radiotherapy (IGRT) sessions using RapidArc technology. This was followed by two CyberKnife boost sessions to high-risk tumour areas - a plan to boost treatment precisely where it was most needed. All sessions went smoothly, with no major side effects. Since October 2024, she has been undergoing her cycle of monthly chemotherapy treatment alongside her regular scanning.Happily, she was also able to slowly get back to work, engage in recreational activities, and gain a semblance of normal life despite the ongoing cancer treatment.

Signs that point to headaches along with seizures, vomiting, blurred vision, confusion, personality changes, weakness, or an increasing frequency of symptoms should be evaluated medically without delay. Even one seizure is not an issue to ignore.

Some symptoms you must mention to your doctor will be:

• Dizziness or headaches

• Constriction
• Trembling and weakness or paralysis
• Memory loss or other indications of memory disorder
• Visual difficulties

It may help you diagnose your problems effectively if you see a neurologist, conduct MRI brain imaging and have consultations from an early stage. While some headaches or seizures do not necessarily mean having a tumor in the brain, regular occurrence of such symptoms with no reason is likely to be examined by an expert. However, although a proper healthy lifestyle may help your brain remain healthy, it will be ineffective for illnesses like GBM.

Dr Sridhar PS, Radiation Oncologist, Apollo Hospitals, Bangalore

Glomerular Diseases affect the glomeruli, which are very small filtering units in the human kidney, and when they get damaged due to disorders, the filters leak blood and vital proteins into the urine and fail to remove waste efficiently. Eventually, these problems can lead to chronic kidney disease or kidney failure. As per its treatment, medications are used to slow kidney damage, manage blood pressure, and reduce protein leakage.

Notably, a new study has revealed hope in this condition by finding that a well-known drug can be very effective in slowing damage if the patient has Glomerular Diseases, and that common drug is Finerenone, which is often prescribed for heart and kidney diseases associated with type 2 diabetes.

The trial was participated in by 903 participants with glomerular diseases. The drug finerenone was given to them. The results show that compared with placebo, it slowed kidney damage, reduced albuminuria, and lowered the risk of kidney failure or sustained loss of kidney function.

Thus, the study clearly indicates that the drug called finerenone may play an important role in protecting kidney function in patients with glomerular diseases.

The research was conducted through subgroup analysis of a phase 3, randomized, double-blind, placebo-controlled trial conducted across 24 countries and regions, focusing on participants with an investigator-reported glomerular disease.

The study was conducted on a large scale, having conducted the research for months in 24 countries and regions. The trial also took care of other important details and implemented all required paperwork, thus securing approvals by regulatory authorities along with ethics committees in every center. Other than that, the participants were required to submit written informed consent. Moreover, an independent data monitoring committee performed safety monitoring throughout the tests.

How To Keep Kidneys Healthy?

Dietary habits can contribute to kidney strain, particularly when busy schedules encourage reliance on convenient foods that are often high in sodium and low in nutritional value.

Hydration habits are additional concerns among office workers. Many professionals rely heavily on coffee, energy drinks, or sugary beverages during long workdays, often replacing plain water as the main source of fluid intake.

Protecting kidney health often begins with small lifestyle changes. Reducing processed food consumption, limiting excessive salt intake, staying adequately hydrated, and maintaining regular sleep schedules can all support kidney function.

Taking short movement breaks during long work hours and managing stress through regular physical activity or relaxation techniques may also help reduce the long-term strain that modern work routines place on the body.