The winter season compels us to sit at one place, under the blanket, at the ease of warmth. But aren't we all aware of the dangers of a sedentary lifestyle? And when it is winter, it makes it more so stagnant. Not just that, but now a new study from the University of Iowa says that being a couch potato could lead to 19 chronic conditions. Among the 19 chronic conditions, obesity, diabetes, depression and heart diseases also made it to the list.

Research shows that among many diseases, increased blood pressure, high blood sugar, excess body fat around the waist, unhealthy cholesterol levels that leads to metabolic syndrome, cardiovascular disease and cancer are also there. This is why any extended sitting whether at desk, behind the wheel or the screen can be harmful.

How was the study conducted?

The team of researchers from various departments at the University of Iowa conducted a detailed study where they analyzed records from over 40,000 patients at a major Midwestern hospital system. In the records, they looked at the extensive physical inactivity of these patients and how it impacted their overall health.

The study and the detailed analysis is published in the journal Preventing Chronic Disease and studies.

As part of conducting the study, a 30-second exercise survey was conducted. Then, patients were also asked two questions: how many days per week they engaged in moderate to vigorous exercise and for how many minutes per session? On the basis of response, the patients were categorized into three groups:

• Inactive - 0 minutes per week
• Insufficiently active - 1-149 minutes per week
• Active - 150 minutes per week

As per Lucas Carr, associate professor in the Department of Health and Human Physiology and study's corresponding author, "This two-question survey typically takes fewer than 30 seconds for a patient to complete so it does not interfere with their visit. But it can tell us a whole lot about that patient's overall health."

What did the study find?

The study got 7,261 responses, and it found that around 60% of them met the recommended guidelines for exercising. These people met the 150 minutes or more minutes of moderate exercise per week. However, almost 36% exercised less than 150 minutes per week and 4% reported no physical activity.

The study also found that people experienced lower rates of depression. 15% of people who exercise for 150 minutes or more, or at least for some amount of time could experience depression, as compared to 26% of those who are inactive. Similarly, for obesity, the numbers are 12% versus 21% for obesity, 20% versus 35% for hypertension and the similar trend was seen in other diseases, and markers of good health, including lower resting pulse rates, and cholesterol profiles.

Patients with no physical activity carried a median of 2.16 chronic conditions, this number was 1.49 conditions in insufficiently active patients and dropped to 1.17 in active patients.

The 19 chronic conditions are:

• Obesity
• Live disease
• Psychoses
• Chronic Lung disease
• Neurological seizures
• Coagulopathy (blood clotting disorder)
• Depression
• Weight loss issues
• Uncontrolled hypertension (high blood pressure)
• Controlled hypertension
• Uncontrolled diabetes
• Anemia deficiency
• Neurological disorder affecting movement
• Peripheral vascular disease
• Auto Immune Disease
• Drug Abuse
• Hypothyroidism
• Congestive heart failure
• Vulvar disease (heart valve problem)

Scientists have created a three-dimensional "heart-on-a-chip" (HOC) model that beats on its own, uses calcium to initiate muscular activity and responds predictably to common drugs in hopes that it will help fight against cardiovascular diseases and heart failure.

This engineered heart is the first to incorporate a dual-sensing platform that provides real-time tracking of activity throughout the heart tissue down to the cellular level, helping scientists measure cellular function, which is critical for preventing heart failure in patients with CVDs.

First author Ali Mousavi, a biomedical engineer at the University of Montreal: "The ability to observe the tissue's response to different compounds in real time represents a major advantage for preclinical development and translational research."

To create their heart-on-chip (HOC) models, researchers collected heart muscle and connective tissue cells from rats. They placed the cells in a gel rich in proteins and nutrients to help them grow, then put them onto tiny, flexible silicon chips.

To measure how the tissue worked, they used two types of sensors. First, they attached the engineered heart tissue between two small elastic pillars. Each time the tissue beat, the pillars bent slightly, and this bending showed how strong the heartbeat was.

Then they placed tiny, soft gel-based sensors inside the tissue. These very small droplets—about 50 micrometers wide—changed shape as the cells contracted. This allowed the researchers to measure mechanical stress at the level of individual cells.

Talking about this development, senior author Houman Savoji, a mechanical and biomedical engineer at the University of Montreal said: "This breakthrough brings us even closer to true precision health by giving us the ability to identify the most effective medication for each person before treatment is even administered."

The Rising Heart Attack Crisis

During a heart attack, a lack of blood flow causes the cells and tissue in the heart muscle to die, leading to irreversible damage that can result in serious complications like arrhythmias, heart failure, cardiogenic shock, or cardiac arrest.

It is one of the leading causes of death in the country. Four Indians experience a heart attack every minute, with one in four dying of the cause. Experts have also noticed a rising trend of nearly 50 percent of heart attack patients being under the age of 40, with half of all heart attacks in Indian men occurring under 50.

Coronary Artery Disease: The Silent KillerCoronary artery disease (CAD) is one of the most common illnesses that can cause a heart attack in people. It develops over years and has no clear signs and symptoms apart from a heart attack.

The illness begins due to a buildup of fats, cholesterol and other substances known as plaque in and on the artery walls.

Over time, this can cause narrowing or blockage of the coronary arteries and block the supply of oxygen-rich blood to the heart which can lead to chest pain (angina), shortness of breath and ultimately, heart attacks.

READ MORE: How This Chinese Medicine Can Improve Blood Flow In Angina Patients

Typically, those above the age of 45, having a biological family member with heart disease, lack of sleep, smoking, consuming saturated fats along with other autoimmune diseases such as lupus and rheumatoid arthritis, can increase the risk of developing CAD.

Nearly one in 10 Indian adults suffer from CAD and about two million people die from the disease annually. Apart from this, about 18 to 20 million American adults aged 20 and older are also affected about the disease.

How Much You Should Exercise To Prevent CAD?

Moreover, regular exercise can also reduce the risk of Type 2 diabetes, high blood pressure, dementia and Alzheimer’s as well as several types of cancer. It can also help improve sleep, cognition, including memory, attention and processing speed.

Dr Hayes recommends opting for a cardiac evaluation such as an electrocardiogram, or EKG; a stress test; a cardiac MRI or CT scan to generate images of your heart if you notice changes in your ability to exercise or cannot perform consistent levels of exercise.

Long-term exposure to tiny air pollution particles can significantly increase your risk of developing Alzheimer's disease-caused dementia.

Researchers from Emory University, US have found that constant exposure to PM2.5 can affect the brain more directly than scientists have assumed.

They noted: "Alzheimer's disease is the most common form of dementia and a growing public health challenge, especially in aging populations. Our findings suggest that PM2.5 exposure was associated with increased Alzheimer's disease risk, primarily through direct rather than comorbidity-mediated pathways."

The scientists also discovered that those who had suffered a stroke were at a slightly higher risk of developing Alzheimer's disease, suggesting that strokes may make the brain more vulnerable to air pollution.

"The observed effect modification by stroke may reflect an underlying biological vulnerability in cerebrovascular pathways. Stroke-related neurovascular damage can compromise the blood–brain barrier, facilitating the translocation of PM2.5 particles or their associated inflammatory mediators into the brain."

The observational study was released in PLOS Magazine.

When Does The Risk Increase?

A new IIT Delhi study suggests the air quality may be worse than what conventional surface monitoring stations capture.

During a post-winter-haze day in March 2021, the researchers measured the vertical distribution of fine particulate matter at 20-metre intervals from the surface up to 100 meters through drones.

At 100 meters, PM2.5 concentrations were around 160 micrograms per cubic meter which is about 60 percent higher than surface readings on the same days. They also found that humidity levels were also higher by 70 percent, which promoted the concentration of ammonium nitrate and chloride.

Additionally, the study found that PM2.5 levels increased sharply near the top of this shallow layer, leading to higher concentrations at around 100 metres.

Based on these observations, the researchers concluded that residents in 28–30-storey buildings may face higher exposure to pollutants and inorganic material than indicated by ground-based monitors.

They also noted that drone-mounted low-cost sensors are a much more effective tool for studying the lower atmospheric boundary layer to improve air quality monitoring, model evaluation and mitigation strategies in cities such as Delhi.

What Is Alzheimer’s Disease?Alzheimer's disease is one of the most common forms of dementia and mostly affects adults over the age of 65.

About 8.8 million Indians aged 60 and above are estimated to be living with Alzheimer's disease. Over seven million people in the US 65 and older live with the condition and over 100,00 die from it annually.

Alzheimer's disease is believed to be caused by the development of toxic amyloid and beta proteins in the brain, which can accumulate in the brain and damage cells responsible for memory.

Amyloid protein molecules stick together in brain cells, forming clumps called plaques. At the same time, tau proteins twist together in fiber-like strands called tangles. The plaques and tangles block the brain's neurons from sending electrical and chemical signals back and forth.

Over time, this disruption causes permanent damage in the brain that leads to Alzheimer's disease and dementia, causing patients to lose their ability to speak, care for themselves or even respond to the world around them.

While there is no clear cause of Alzheimer's disease, experts believe it can develop due to genetic mutations and lifestyle choices, such as physical inactivity, unhealthy diet and social isolation.

Early symptoms of Alzheimer's disease include forgetting recent events or conversations. Over time, Alzheimer's disease leads to serious memory loss and affects a person's ability to do everyday tasks.

There is no cure for this progressive brain disorder and in advanced stages, loss of brain function can cause dehydration, poor nutrition or infection. These complications can result in death.

Frequently experiencing deep sleep may help prevent the development of brain changes related to Alzheimer's Disease, the most common form of dementia.

Researchers from the University of California, Berkeley, Stanford University, and UC Irvine in the US have found that people experiencing early symptoms of Alzheimer's performed better on memory function tests as they got more deep sleep.

This sign was found to be independent of education and physical activity, two factors, along with social connection, known to contribute to cognitive resilience in older age.

Those with similar Alzheimer's-linked changes who failed to get as much deep sleep did not do as well on the same tests. By comparison, sleep made little difference to those individuals with few Alzheimer's-related deposits.

The results imply that a frequently being able to sleep deeply frequently could help support the memory decline that sets in as dementia begins to take hold.

UC Berkeley neuroscientist Matthew Walker said of the results: "Think of deep sleep almost like a life raft that keeps memory afloat, rather than memory getting dragged down by the weight of Alzheimer's disease pathology.

"This is especially exciting because we can do something about it. There are ways we can improve sleep, even in older adults."

Previous research has also shown that poor sleep is both a risk factor for and a symptom of Alzheimer's disease, making it tricky for scientists to detect how sleep is linked to neurological damage.

What Is Alzheimer’s Disease?Alzheimer's disease is one of the most common forms of dementia and mostly affects adults over the age of 65.

About 8.8 million Indians aged 60 and above are estimated to be living with Alzheimer's disease. Over seven million people in the US 65 and older live with the condition and over 100,00 die from it annually.

Alzheimer's disease is believed to be caused by the development of toxic amyloid and beta proteins in the brain, which can accumulate in the brain and damage cells responsible for memory.

Amyloid protein molecules stick together in brain cells, forming clumps called plaques. At the same time, tau proteins twist together in fiber-like strands called tangles. The plaques and tangles block the brain's neurons from sending electrical and chemical signals back and forth.

Over time, this disruption causes permanent damage in the brain that leads to Alzheimer's disease and dementia, causing patients to lose their ability to speak, care for themselves or even respond to the world around them.

While there is no clear cause of Alzheimer's disease, experts believe it can develop due to genetic mutations and lifestyle choices, such as physical inactivity, unhealthy diet and social isolation.

Early symptoms of Alzheimer's disease include forgetting recent events or conversations. Over time, Alzheimer's disease leads to serious memory loss and affects a person's ability to do everyday tasks.

There is no cure for this progressive brain disorder and in advanced stages, loss of brain function can cause dehydration, poor nutrition or infection. These complications can result in death.

Can You Detect Alzheimer's Early On?

The blood test, known as Lumipulse, can detect amyloid plaques associated with Alzheimer’s disease and has proven to be a “less invasive option” that “reduces reliance on PET scans and increases diagnosis accessibility.”

FDA Commissioner Martin A. Makary said of the landmark decision, "Alzheimer’s disease impacts too many people, more than breast cancer and prostate cancer combined.

"Knowing that 10 percent of people aged 65 and older have Alzheimer's, and that by 2050 that number is expected to double, I am hopeful that new medical products such as this one will help patients."

It remains unclear when this test will be available for commercial use across the world.