With the holiday season high, there is festive cheer, family gatherings and also an undeniable increases in alcohol consumption that fills the air. Christmas and New Year's Eve celebrations to spring break and bachelor parties and sporting events that bring together huge crowds for celebrations mean that drinking becomes synonymous with partying. But behind the revelry lies a much darker behavior: high-intensity drinking.

Alcohol is the most widely used substance in the United States; it has been reported that 84% of adults aged 18 and older reported lifetime use. Moderate drinking is socially acceptable, but high-intensity drinking is an alarming trend. The behavior of consuming eight or more drinks over a few hours for women and 10 or more for men exceeds binge drinking and significantly increases risk for harm.

High-intensity drinking is far from being just a mere passing concern; it is instead a public health crisis. The burden is even greater as 29 million people in the United States suffer from alcohol use disorder. That has caused over 140,000 deaths annually while accounting for 200,000 hospitalizations and 7.4% of visits to emergency departments in the United States. However, only 7.6% of these affected get treated, thus forming a glaring gap in handling this concern.

What Is High-Intensity Drinking?

High-intensity drinking is a dangerous escalation from traditional binge drinking, characterized by consuming double or triple the standard binge amounts. While binge drinking involves four or more drinks for women and five or more for men, high-intensity drinkers often surpass these levels, leading to blood alcohol concentrations (BAC) exceeding 0.2%—a level that significantly impairs judgment and motor skills.

According to Dr. George Koob, the director of the National Institute on Alcohol Abuse and Alcoholism (NIAAA), high-intensity drinking is one of the factors that intensify the risks of injuries, overdose, and death. It is also very highly associated with the onset of AUD, since the chance of addiction increases with increased alcohol consumption per occasion.

Blackouts and Memory Loss Risks

One of the most troubling consequences of high-intensity drinking is alcohol-induced blackouts, periods of amnesia where individuals may appear functional but are incapable of forming memories. Blackouts occur when alcohol disrupts the hippocampus, the brain region responsible for memory formation.

Blackouts are often categorized into two types:

1. Fragmentary Blackouts: Characterized by spotty memory, where recalling certain details can trigger partial recollection.

2. En Bloc Blackouts: Significant amnesia for hours, wherein no memory is created at all, even if tried to be recalled.

Aside from memory loss, intense binge drinking is linked with poor decision-making, violence, injury, and conflicts in personal relationships.

Why Holidays and Special Events Are Hotbeds for Excessive Drinking

Holidays and celebrations create the perfect storm for high-intensity drinking. According to research, adults drink nearly double the amount of alcohol during holidays like Christmas and New Year's Eve than they do at any other time of the year. It is during these periods of social gathering, holiday stress, and seasonal sadness that people drink in excess.

For college students, experiences like spring break and 21st birthdays increase the danger. Some studies indicate that students, especially those who travel with buddies to spring break, indulge in more alcohol and make more serious decisions than any student who remains at home or goes with their family to other destinations. Sporting events are, too, notorious for promoting drunk consumption, especially among male customers. Alcohol consumption usually goes high during Super Bowl Sunday, thus leading to games day violence and arrests.

Consequences of Heavy Intensity Drinking

High-intensity drinking impacts not only physical health and mental well-being but also social relationships.

Acute Risks

- Alcohol poisoning

- Severe dehydration and electrolyte imbalances

- Hypoglycemia

- Risky sexual behavior

- Injuries and accidents

Chronic Risks

- Liver damage, alcoholic hepatitis, and cirrhosis

- Cardiovascular diseases such as arrhythmias and cardiomyopathy

- Neurological damage, including memory deficits and blackouts

- Progression to alcohol dependence or AUD

Psychological Impact

High-intensity drinking is strongly linked with increased risks of depression, anxiety, and suicidal ideation. Poor decision-making during episodes can lead to long-lasting consequences, including damaged academic, professional, or personal outcomes.

How to Address the Problem

Combating high-intensity drinking requires education, early intervention, and accessible treatment options. The NIAAA has defined high-intensity drinking to be distinct from binge drinking and has called for targeted approaches to decline prevalence and associated harms.

One promising treatment option is naltrexone, which a medication helps control alcohol cravings. Encouraging in preliminary evidence, more extensive clinical trials will be necessary to ascertain its efficacy more specifically in high-intensity drinkers.

As we head into the holiday season and other special occasions, it is important to heighten awareness of the dangers of high-intensity drinking. A good understanding of long-term consequences and seeking help when alcohol-related issues arise can be the difference between life and death. Celebrations should be about joy and connection, not about the gateway to harm.

If you or someone you know drinks at dangerous levels or have an alcohol use disorder, there is help available. Remember, for suspected cases of alcohol poisoning, dial 911. In this way, we can foster healthier relationships with alcohol and create safer environments for everyone.

The brain is a crucial component of the human body. It is an integral part of the whole system, but when the body ages, the brain does too. The brain is the organ that plays a big role in the aging process. The brain protein is an important component of the body, and can positively impact inflammation, memory decline, and other age-related changes.

A recent study conducted by PLOS Biology claims that the brain protein Menin loss can be crucial to inflammation, memory decline, and other age-related changes. The researchers in the study used mice as test subjects and tried to restore the very protein in them, which worked marvelously; aging conditions were completely reversed.

The study found that aging can be highly influenced by the hypothalamus, a strong brain region that regulates metabolism, hormones, body temperature, sleep, and stress responses. According to the researchers, the hypothalamus is a central command centre for aging.

The research was done by Lige Leng and colleagues at Xiamen University in China and mainly focused on the Menin. They intended to see what the impact would be if someone lost this very important protective protein. The study on mice shows that when Menin levels drop in the hypothalamus, it causes faster aging.

The study specifically used young mice and reduced menin levels; as a result, they faced brain inflammation, thinning skin, lower bone mass, impaired balance, memory problems, and a shorter lifespan. Thus, the conclusion of the research was that menin is likely to act as an anti-aging component in the body.

How Much Protein Do You Really Need?

Your protein needs aren’t one-size-fits-all. They depend on several factors: your weight, age, physical activity, body composition goals, and overall health status.

The Recommended Dietary Allowance (RDA) for the average adult is 0.36 grams per pound (0.8 grams per kilogram) of body weight. This amount is to meet basic nutritional needs in most sedentary adults.

However, experts suggest that physically active people often need more, anywhere from 0.54 to 0.9 grams per pound (1.2–2 grams per kilogram) per day. Athletes may even require higher amounts to support muscle repair and performance.

Certain groups, such as pregnant or breastfeeding individuals, older adults, and people recovering from illness or injury, also have increased protein needs. For example, during pregnancy, the recommendation rises to about 0.5 grams per pound (1.1 grams per kilogram).

According to the World Health Organization (WHO), tobacco use kills over 8 million people globally each year, including non-smokers exposed to second-hand smoke.

India continues to face a massive burden of tobacco addiction. Cigarettes, bidis, gutka, pan masala and khaini continue to affect millions, including young adults. This year’s WHO theme- “Unmasking the Appeal: Countering Nicotine and Tobacco Addiction” focuses on how flavoured products, attractive packaging and social media marketing are making nicotine products appealing to the younger generation.

Tobacco damages nearly every organ in the body. It is strongly linked to cancers of the mouth, throat, voice box, lungs, food pipe and bladder. In India, oral cancer remains one of the commonest cancers, largely driven by smokeless tobacco use. Tobacco also increases the risk of heart attacks, strokes, chronic lung disease, infertility and poor immunity.

Many people mistakenly believe that e-cigarettes and vaping are “safe alternatives.” However, e-cigarettes still contain addictive nicotine and harmful chemicals that can damage the lungs and cardiovascular system. They may also act as a gateway to conventional tobacco use among teenagers and young adults. Recognising these risks, India banned the production, sale and advertisement of e-cigarettes under the Prohibition of Electronic Cigarettes Act, 2019.

The encouraging fact is that quitting works at any age. Within weeks of stopping tobacco, blood pressure and lung function begin to improve, while long-term risks of cancer and heart disease reduce significantly.

Simple Steps To Quit Tobacco

* Fix a quit date and inform family and friends.

* Identify triggers such as stress, tea, alcohol or social gatherings.

* Avoid keeping tobacco products nearby.

* Stay physically active and hydrated.

* Seek professional counselling if cravings are severe.

* Nicotine replacement therapy or prescribed medications may help selected individuals.

* Remember that relapses can happen and restarting the quit journey is still progress.

World No Tobacco Day is not just about awareness but is a call to action. Choosing to quit today may be the single most important decision for a healthier and longer life.

(Dr Akshat Malik, Senior Consultant, Head & Neck Oncology, Apollo Hospital, Delhi)

According to the Indian Council of Medical Research - National Cancer Registry Programme (ICMR-NCRP), India reports about 220,000 new cases every year, and the common treatment procedure for this disease is chemotherapy, which comes with profound fatigue, hair loss, nausea, compromised immunity, and nerve damage.

The University College London led the Optima trial, which studied over 4000 patients with the disease in different parts of the world, and a low score on the genomic test could be mediated with only hormone therapy.

The trial’s chief investigator and a professor of breast oncology at UCL, Professor Rob Stein, explains that the study used tumour biology to guide decisions instead of relying on traditional clinical procedures.

The research had 4,429 women participants above the age of 40 years with hormone-positive breast cancer. These patients were then divided into two groups based on the genomic test results by the researchers, and one group with a higher risk was given chemotherapy along with hormone therapy, while the others were only treated with hormone therapy.

What Is Breast Cancer?

Breast cancer refers to the uncontrolled growth of the cells that are found along the inner lining of breast tissue. This out-of-control growth of cells leads to the formation of tumours. The tumour can be “invasive”, meaning that it spreads to the nearby tissues outside the breast, or “in situ”, where the tumour does not spread outside the breast region.

Usually, the “in situ” type of tumour is non-cancerous and non-life-threatening. However, in the case of invasive tumours, the cancerous cell mass can spread to the lymph nodes and further metastasise, that is, spread to other body parts. About 80% times the breast cancer cases are invasive. Hence, upon noticing symptoms like lumps, changes in breast shape, or abnormal nipple discharge, you must promptly consult a doctor.

While both men and women can develop it, in 99% of cases of breast cancer, women are seen to be affected by it. Only 0.5 to 1% of men are affected due to this condition. Furthermore, the condition is mostly prevalent in women aged 50 or older.