With the holiday season high, there is festive cheer, family gatherings and also an undeniable increases in alcohol consumption that fills the air. Christmas and New Year's Eve celebrations to spring break and bachelor parties and sporting events that bring together huge crowds for celebrations mean that drinking becomes synonymous with partying. But behind the revelry lies a much darker behavior: high-intensity drinking.

Alcohol is the most widely used substance in the United States; it has been reported that 84% of adults aged 18 and older reported lifetime use. Moderate drinking is socially acceptable, but high-intensity drinking is an alarming trend. The behavior of consuming eight or more drinks over a few hours for women and 10 or more for men exceeds binge drinking and significantly increases risk for harm.

High-intensity drinking is far from being just a mere passing concern; it is instead a public health crisis. The burden is even greater as 29 million people in the United States suffer from alcohol use disorder. That has caused over 140,000 deaths annually while accounting for 200,000 hospitalizations and 7.4% of visits to emergency departments in the United States. However, only 7.6% of these affected get treated, thus forming a glaring gap in handling this concern.

What Is High-Intensity Drinking?

High-intensity drinking is a dangerous escalation from traditional binge drinking, characterized by consuming double or triple the standard binge amounts. While binge drinking involves four or more drinks for women and five or more for men, high-intensity drinkers often surpass these levels, leading to blood alcohol concentrations (BAC) exceeding 0.2%—a level that significantly impairs judgment and motor skills.

According to Dr. George Koob, the director of the National Institute on Alcohol Abuse and Alcoholism (NIAAA), high-intensity drinking is one of the factors that intensify the risks of injuries, overdose, and death. It is also very highly associated with the onset of AUD, since the chance of addiction increases with increased alcohol consumption per occasion.

Blackouts and Memory Loss Risks

One of the most troubling consequences of high-intensity drinking is alcohol-induced blackouts, periods of amnesia where individuals may appear functional but are incapable of forming memories. Blackouts occur when alcohol disrupts the hippocampus, the brain region responsible for memory formation.

Blackouts are often categorized into two types:

1. Fragmentary Blackouts: Characterized by spotty memory, where recalling certain details can trigger partial recollection.

2. En Bloc Blackouts: Significant amnesia for hours, wherein no memory is created at all, even if tried to be recalled.

Aside from memory loss, intense binge drinking is linked with poor decision-making, violence, injury, and conflicts in personal relationships.

Why Holidays and Special Events Are Hotbeds for Excessive Drinking

Holidays and celebrations create the perfect storm for high-intensity drinking. According to research, adults drink nearly double the amount of alcohol during holidays like Christmas and New Year's Eve than they do at any other time of the year. It is during these periods of social gathering, holiday stress, and seasonal sadness that people drink in excess.

For college students, experiences like spring break and 21st birthdays increase the danger. Some studies indicate that students, especially those who travel with buddies to spring break, indulge in more alcohol and make more serious decisions than any student who remains at home or goes with their family to other destinations. Sporting events are, too, notorious for promoting drunk consumption, especially among male customers. Alcohol consumption usually goes high during Super Bowl Sunday, thus leading to games day violence and arrests.

Consequences of Heavy Intensity Drinking

High-intensity drinking impacts not only physical health and mental well-being but also social relationships.

Acute Risks

- Alcohol poisoning

- Severe dehydration and electrolyte imbalances

- Hypoglycemia

- Risky sexual behavior

- Injuries and accidents

Chronic Risks

- Liver damage, alcoholic hepatitis, and cirrhosis

- Cardiovascular diseases such as arrhythmias and cardiomyopathy

- Neurological damage, including memory deficits and blackouts

- Progression to alcohol dependence or AUD

Psychological Impact

High-intensity drinking is strongly linked with increased risks of depression, anxiety, and suicidal ideation. Poor decision-making during episodes can lead to long-lasting consequences, including damaged academic, professional, or personal outcomes.

How to Address the Problem

Combating high-intensity drinking requires education, early intervention, and accessible treatment options. The NIAAA has defined high-intensity drinking to be distinct from binge drinking and has called for targeted approaches to decline prevalence and associated harms.

One promising treatment option is naltrexone, which a medication helps control alcohol cravings. Encouraging in preliminary evidence, more extensive clinical trials will be necessary to ascertain its efficacy more specifically in high-intensity drinkers.

As we head into the holiday season and other special occasions, it is important to heighten awareness of the dangers of high-intensity drinking. A good understanding of long-term consequences and seeking help when alcohol-related issues arise can be the difference between life and death. Celebrations should be about joy and connection, not about the gateway to harm.

If you or someone you know drinks at dangerous levels or have an alcohol use disorder, there is help available. Remember, for suspected cases of alcohol poisoning, dial 911. In this way, we can foster healthier relationships with alcohol and create safer environments for everyone.

For people living with primary sclerosing cholangitis or PSC, medical options have always been painfully limited. Until now, there has been no approved drug that can slow the disease itself. Treatment has mostly meant managing symptoms and waiting, often for years, until a liver transplant becomes the only option. That is why new results around a monoclonal antibody called nebokitug are being seen as a turning point.

Researchers from the University of California Davis have reported promising findings from a Phase 2 clinical trial showing that nebokitug appears safe and may actually reduce liver inflammation and scarring. The study was published in the American Journal of Gastroenterology and has brought cautious optimism to both doctors and patients.

What Exactly Is PSC?

PSC is a rare, long-term liver disease that mainly affects the bile ducts. These ducts act like tiny pipelines that carry bile from the liver to the small intestine, where it helps digest fats. In PSC, these ducts become inflamed, damaged, and scarred over time. As they narrow, bile starts backing up in the liver, slowly causing liver injury.

Many people with PSC also have inflammatory bowel disease, especially ulcerative colitis. This strong link has led researchers to believe that ongoing gut inflammation may trigger immune reactions that damage the liver as well. Symptoms can range from extreme tiredness and itching to yellowing of the skin and eyes. Some patients have no symptoms at all in the early stages, which makes the disease harder to catch.

Why Treatment Has Been So Difficult

One of the biggest challenges with PSC is that doctors have not had a way to stop the scarring process itself. Once fibrosis sets in, it slowly progresses and increases the risk of liver failure and bile duct cancer. While medications can help with itching or infections, they do not change the course of the disease. This gap in treatment is what makes the nebokitug study so important.

How Nebokitug Works

Nebokitug is a lab-made antibody designed to block a protein called CCL24. This protein plays a key role in driving inflammation and fibrosis in the liver. In people with PSC, CCL24 levels are higher than normal and are found around the bile ducts where damage is most severe.

By blocking CCL24, nebokitug aims to calm the immune response and slow down the scarring process. Earlier lab and animal studies suggested this approach could work. The new trial is one of the first to test this idea in people with PSC.

What the Trial Found

The Phase 2 study included 76 patients from five countries. Participants received either one of two doses of nebokitug or a placebo through an IV every three weeks for 15 weeks. The main goal was to check safety, since this was still an early-stage trial.

The results were encouraging. Nebokitug was found to be safe and well tolerated. More importantly, patients who already had more advanced liver scarring showed improvements in liver stiffness and markers linked to fibrosis when compared to those on placebo. These changes suggest that the drug may be doing more than just easing symptoms.

Experts involved in the study say these findings could change the future of PSC care. Reducing inflammation and fibrosis could slow disease progression and delay or even prevent the need for a transplant in some patients. While larger trials are still needed, nebokitug represents one of the strongest signals yet that PSC may finally have a disease-modifying treatment on the horizon.

Now, drinking beer too could increase the risk of mouth cancer. On Tuesday, researchers at the Tata Memorial Centre (TMC) reported this adding new evidence. They found a 59 per cent higher risk of mouth cancer in people who drank, on average, just two grams of alcohol from beer daily, compared with those who did not drink. The research suggests that there may not be any safe limit to drink.

What Did The Study Reveal About Beer And Cancer?

Their study in India's large scale analysis that probs link between alcohol and cancer of the buccal mucosa. This is the pink lining of cheeks and lips. In India, this kind of cancer is the second most common malignancy in India after breast cancer. It also leads to 1,40,000 new cases and nearly 80,000 deaths each year.

Who Are More Prone To Buccal Mucosa Cancer?

People who consume more than one glass of alcohol a day and chew tobacco on a day to day basis are five times more at risk of developing this cancer as compared to those who do not drink or chew tobacco.

The findings of the study was published in the journal BMJ Global Health and it suggests that joint use of both, alcohol and tobacco leads to 62 per cent of all buccal mucosa cancer in the country.

As Telegraph reported, Tata Memorial Centre for Cancer Epidemiology unit's head of molecular epidemiology and population genomics unit Sharayu Mhatre said, "We see an unmistakable pattern: the more alcohol people drink, the greater their risk of buccal mucosal cancer."

Buccal mucosal cancer continues to pose a serious public health challenge in India. Among 100 patients diagnosed with locally advanced stages of the disease, 57 die within five years, a mortality rate that experts say highlights the urgent need for prevention, early detection, and stronger regulation of risk factors.

Alcohol Emerges as a Major Risk Factor

While the link between alcohol and cancer is well known, new findings reinforce just how dangerous alcohol consumption can be for oral health. Researchers found that people who consumed alcohol had a 68% higher risk of developing buccal mucosal cancer compared to non-drinkers.

What stood out most was the type of alcohol consumed. Unregulated, locally brewed liquor carried the highest risk, increasing cancer likelihood by 87%, compared to 72% among consumers of regulated, commercially sold drinks. Experts point out that these local brews often contain significantly higher ethanol concentrations and lack quality control.

Not Just Heavy Drinking—Even Small Amounts Matter

The study analyzed drinking patterns among over 3,700 participants, comparing cancer patients with healthy individuals. Alcohol types ranged from beer and spirits like whisky and vodka to traditional local drinks such as bangla and tharra. Ethanol levels varied widely—from 5% in beer to as high as 90% in some locally distilled spirits.

Alarmingly, increased cancer risk was seen even at low levels of alcohol intake. As little as two grams of alcohol a day from beer, or roughly one glass of stronger liquor, was enough to raise concern.

Alcohol and Tobacco: A Dangerous Combination

The risk escalates dramatically when alcohol use is combined with tobacco chewing. Tobacco alone raised cancer risk by 200%, alcohol alone by 76%, but together, the risk shot up to 346%. Researchers explain that alcohol may damage the mouth’s protective lining, making it easier for tobacco-related carcinogens to penetrate and cause harm.

Health experts stress that these findings underline the need for greater public awareness, stricter monitoring of locally brewed alcohol, and stronger prevention strategies. The World Health Organization has already warned that no level of alcohol is safe, noting that even light or moderate drinking contributes to a significant number of alcohol-related cancers globally.

For India, where oral cancers remain widespread, these insights serve as a critical reminder: everyday habits can have life-altering consequences.

Delhi finds itself in a little relief as the AQI of the city has dropped to 221 as per the CAQM. GRAP IV restrictions have also been lifted, however, pollution and smog continues to take over the city. The Meteorological Department has issued a yellow alert for the next few days, which could affect road and air traffic.

While GRAP IV is now removed, measures under GRAP I, II, and III will continue. As per the IMD forecast, this is what could happen for the next 5 days in Delhi

• December 26: Dense fog will prevail in the morning. Visibility is likely to be low.
• December 27: Yellow alert, dense fog in the morning and afternoon.
• December 28: Yellow alert, moderate to dense fog expected in the early morning.
• December 29-30: Fog will reduce slightly, but moderate haze will prevail in the morning.

Union Transport Minister On Delhi's Pollution

Nitin Gadkari, Union Minister of Road Transport and Highways also highlighted the alarming conditions of Delhi's smog and pollution. He said, "I stay for hardly two days in Delhi, and get an infection," as he spoke on how pollution impacts one's health conditions. However, he did speak on the severity of pollution and highlighted how the transport sector could play a huge role to bring relief to Delhi.

He highlighted that fuel combustion and transport emission leads to most of Delhi pollution.

In an interview with the news agency ANI, the minister also said that his ministry and Central Government are working on several projects and initiatives that will free Delhi from air pollution in the next five years.

Gadkari stated that the Ministry of Road Transport and Highways is undertaking projects worth Rs 1 lakh crore in Delhi to ease traffic congestion. He stated that all these efforts will not only help free Delhi of air pollution but also reduce the country's imports, increase job opportunities, and help farmers.

Electric Buses, Cars, and Scooters

The minister highlighted that 40% of the air pollution in the National Capital region is due to the burning of fossil fuels. In this regard, the government introduced electric buses in the city and enabled automakers to introduce electric cars and two-wheelers in the country.

He further stated that alternate fuel vehicles, such as those that run on CNG, LPG, and flex fuels (E20), are also being introduced and that all these efforts combined will reduce the city's pollution levels.

CNG And Bitumin From Rice Straw

Gadkari pointed out that nearly 200 lakh tonnes of rice straw or parali is burnt in Haryana and Punjab, a major cause of air pollution in the Delhi-NCR region. In this regard, the government is setting up 400 plants to convert the rice straw into CNG. At the moment, 60 plants are operational.

The minister also discussed a new project in Panipat in which rice straw is being used to create 1 lakh litres of Ethanol, 1.5 tonnes of bitumen, and 78,000 tonnes of jet fuel.