The COVID-19 pandemic may be over, but our immune systems are still feeling the impact. After years of battling constant viral threats, from COVID-19 to seasonal flu and other infections, our body’s defense system is exhausted. Many people continue to experience lingering inflammation, frequent illnesses, and slower recovery times. This extended state of immune stress has compromised us further to chronic illness, including autoimmune diseases and even neurodegenerative diseases such as Parkinson's. So why is our immune system still in trouble? And how do we give it its power back? Understanding immune exhaustion is the beginning of rebuilding our body's natural immunity.

A weakened immune system makes people more susceptible to disease, mental illnesses, and even sleep disorders. Now, new research indicates that immune system depletion may play an important role in the onset of Parkinson's disease, a degenerative neurologic disorder that compromises movement and cognition.

Role of Inflammation in Parkinson's Disease

Dysfunctional immune response is a leading cause of long-standing inflammation within the body, that has been found to contribute towards a multitude of conditions, including cardiovascular conditions, diabetes, depression, and neurodegenerative diseases such as Alzheimer's.

As people age, their immune system naturally becomes less effective. This deterioration, referred to as immune exhaustion, may be a key contributor to the onset and progression of Parkinson’s disease. Rebecca Wallings, a Parkinson’s Foundation Launch Award grant recipient and senior postdoctoral fellow at the University of Florida, believes that an accumulation of exhausted immune cells could be driving neurodegeneration in Parkinson’s patients.

How a Tired Immune System Might Affect Parkinson's?

Parkinson's disease is most commonly linked with the degeneration and loss of dopaminergic neurons—motor nerve cells that produce dopamine, an essential neurotransmitter for movement. While researchers have long suspected inflammation is involved in this neurodegeneration, the mechanisms are not yet well understood.

Wallings' study is on immune cell exhaustion, a process by which aging immune cells fail to control immune responses effectively. Her research indicates that instead of dampening inflammation in Parkinson's patients, attempts should be made to rejuvenate the immune system to regain its functionality.

Energy Deficiency in Immune Cells

One of the major findings of Wallings' work is the function of mitochondrial impairment in immune cell exhaustion. Mitochondria are commonly called the powerhouses of cells, as they are vital for generating energy. As mitochondria age and become inefficient, immune cells fail to function well, potentially accelerating neurodegeneration in Parkinson's disease.

Wallings has found that mutations in the LRRK2 gene, a recognized genetic risk factor for Parkinson's disease, are linked with defective mitochondrial function and immune cell exhaustion. Her current work includes testing various therapeutic approaches to restore mitochondrial function in immune cells with the potential to enhance the immune system and potentially prevent or treat Parkinson's disease.

Will Rejuvenating the Immune System Help in Treatment?

For decades, the standard practice in treating Parkinson's has been to suppress brain inflammation. Yet Wallings' work indicates that instead of slowing down immune responses, restoring the immune system could be a more successful strategy. By addressing mitochondrial impairment and immune resilience, researchers can potentially reverse or slow down Parkinson's disease.

Wallings is now looking into how to rejuvenate immune cells by fixing mitochondria. She studies immune cells from patients with Parkinson's as well as from healthy subjects and performs experiments on animal models to determine if rejuvenation of the immune system could result in improved disease outcomes.

Lifestyle Factors That May Affect Parkinson's Risk

While there is no cure for Parkinson's disease, some lifestyle adjustments may decrease the chances of developing the illness. Since neurodegenerative diseases are associated with chronic inflammation and immune dysfunction, developing habits that enhance immune function might prove helpful.

Diet: There is evidence to suggest that eating in accordance with the Mediterranean or MIND diets, both high in antioxidants, healthy fats, and anti-inflammatory foods, can encourage brain wellness and reduce Parkinson's risk.

Avoiding Dangerous Substances: Restricting alcohol and nicotine use can maintain a robust immune system and suppress inflammation.

Reducing Stress: Chronic stress weakens immune function, so methods such as meditation, exercise, and sufficient sleep can lead to improved overall well-being.

Screening for all men is "likely to cause more harm than good", says the UK National Committee. This recommendation is based on a clinical trial called Transform, which is now filling gaps in the evidence on how screening could be safely rolled out to other groups.

As of now, as per the recommendation, men who are between the ages of 45 and 61 should be screened every two years, if they have specific genetic mutations called BRCA variants.

The UK National Screening Committee recommends:

• No screening for black men due to "uncertainties" around the impact due to a lack of clinical trials in black men
• No screening based on family history

Why Is The New Recommendation Asking People To Not Get Screened For Prostrate Cancer?

As per the clinical study and the Cancer Research UK, of the 1000 men who get screened between the age of 50 to 60 for PSA test or the prostate-specific antigen test, around 100 have a positive PSA test. Of them, 34 have a positive MRI and receive a biopsy. Then only 28 are diagnosed with prostrate cancer. Of those 28, 10 are offered active surveillance, 13 are offered surgery or radiotherapy, and 4 need surgery or radiotherapy, while 1 need any other treatment.

However, the Cancer Research UK notes that while 1000 men are screening, and 28 diagnosed, only 2 lives could be saved, with 20 being over diagnosed, this means they have a slow-growing tumor that does not need treating, and of them 12 men will receive treatments that do not benefit them, rather harms them. These harms come in forms like being unable to control your bladder, or maintain an erection.

Is Prostrate Cancer Screening Recommendation Fit For All?

While experts say it is, patients are disappointed. Sir Chris Hoy, a terminal prostrate cancer patient says he was "disappointed and saddened" by the new recommendations as BBC reports.

However, Prof Freddie Hamdy, who is a urological surgeon in Oxford tells BBC: "The diagnosis of prostrate cancer in a healthy man is hugely disruptive event, with potential to affect quality of life, very significantly, for many years."

"It cannot be done lightly, men need to be really well counselled and informed before the 'snowball' starts. Before you know it, you are on the operating table having your prostate removed – and we see examples of that all the time," he said.

The screening committee’s decision is not final. It marks the beginning of a three-month public consultation period, after which the committee will reconvene and present its final recommendations to ministers in England, Wales, Scotland, and Northern Ireland. Each nation will then make its own decision on prostate screening.

England’s Health Secretary Wes Streeting said he supports screening “if backed by evidence” and promised to review the data “thoroughly” ahead of the final guidance expected in March.

Reactions to the draft recommendations have been sharply divided. Cancer Research UK welcomed the consideration of screening for men with faulty BRCA genes and agreed that, for most men, screening could currently do more harm than good.

But others strongly disagreed. Sir Chris Hoy said he was “extremely disappointed and saddened,” calling the BRCA-specific recommendation “a very small step forward” that falls short. Sharing his own experience, he emphasised that “early screening and diagnosis saves lives.”

Prostate Cancer UK CEO Laura Kerby also expressed being “deeply disappointed,” saying the decision will “come as a blow” to tens of thousands of men.

Prostate Cancer Research criticized the move as “a serious error that ignores modern evidence,” calling it a missed opportunity for Black men and those with a family history.

Many people struggle to fall asleep because their minds race with worries about the next day or even old memories. To stop this mental chatter, some try complicated breathing exercises or relaxation hacks. However, a simple neuroscience trick involving temperature might help you drift off instantly.

Neuroscientist Kyle Cox suggests that you can fall asleep in seconds simply by placing something cold on your forehead when you go to bed. He explains that this method has been backed by sleep clinics and can be highly effective.

Sleep Hack That Could Help You Sleep Quicker

Researchers have learned that the temperature right on your forehead controls whether your brain stays active or decides to rest.

When the front part of your brain, called the frontal lobe, gets cooled down by even a little bit, just one degree, it automatically tells your body to start producing the chemicals needed for sleep.

The cold also quickly slows down all that busy mental chatter because the part of your brain that handles thinking (the prefrontal cortex) literally cannot work as hard when it is being cooled down.

A 2018 study published in the Sleep Journal also found similar results through a device that that cooled the forehead temperature as a treatment for insomnia. The device improved things like the time it took to fall asleep compared to the patient's own baseline sleep and the time it took to enter different stages of light and deep sleep (NREM Stages 1 and 2).

The two-night treatment helped patients fall asleep faster according to most PSG measurements and was safe. The researchers recommend more studies to see if this treatment works for the longer-term management of insomnia.

General Tips for Treating Insomnia

If you struggle with sleep, the NHS (National Health Service) says that often the best cure is to change your daily sleep habits. If you stick to a healthier routine, your insomnia usually gets much better over time.

Keep a Schedule

Go to bed and set your alarm to wake up at the exact same time every day, even on weekends. This helps set your body's internal clock.

Wind Down

Start relaxing at least one hour before you plan to sleep. This could mean taking a warm bath, listening to calm music, or reading a physical book.

Optimize Your Room

Make your bedroom a perfect place for sleeping. It should be as dark and quiet as possible. Use heavy curtains, blinds, or even an eye mask and earplugs if needed.

Get Moving

Exercise is great for sleep, but do it regularly during the day, not right before bed.

Be Comfortable

Check that your mattress, pillows, and blankets are supportive and cozy so you can easily relax once you lie down.

Things You Should Avoid For Better Sleep

To sleep better, avoid things that keep you awake. Stop smoking, drinking caffeine or alcohol six hours before bed. Do not eat a large meal or exercise intensely late at night. Avoid screens right before bed, limit daytime naps, and always stick to your regular morning wake-up time.

Researchers have recently found that looking closely at the shape of the main buttock muscle, called the gluteus maximus, gives important clues about a person's health. This muscle shape reflects key changes linked to how we age, our lifestyle choices, and medical problems like diabetes.

This new study, done by a team at the University of Westminster, is unique because, unlike older research that only measured how big the muscle was, the team used advanced 3D mapping to show exactly where and how the muscle shape was changing.

These shifts, either the muscle shrinking (atrophy) or becoming inflamed, are connected to things like being frail, the amount of time someone sits each day, fat storage and diabetes risk.

How Do Muscle Changes Indicate Diabetes Risk?

the research analysed a large dataset, looking at over 61,000 MRI scans taken from the large U.K. Biobank health database.

Along with the MRI images, the dataset also included detailed information on 86 different factors for each person, including their medical history, body measurements, and what kind of lifestyle they led.

By putting all this data together, the team was able to figure out which specific factors were strongly linked to changes in the shape of the buttock muscle over time.

The analysis revealed strong connections between muscle shape and certain health factors:

Fitness

People who were considered fitter, meaning they reported doing more vigorous physical activity and had a stronger hand grip, tended to have a greater gluteus maximus shape. This often means the muscle was larger and more defined.

Aging and Frailty

On the other hand, factors like getting older, being generally frail (weak), and spending many hours sitting were all linked to muscle thinning or shrinkage. This suggests that a lack of use and the natural process of aging reduce the muscle's size and fullness.

How Gender Affects Muscle Responses

A very important discovery was that the gluteal muscles don't change in the same way for men and women, especially when they are dealing with a disease. For example, men who were considered frail showed more shrinkage (thinning) in their gluteus maximus compared to women who were also frail.

When the researchers examined Type 2 diabetes, the difference was even more noticeable: diabetic men showed clear muscle thinning (reduced muscle mass), while diabetic women often showed enlarged muscle mass.

This larger appearance in women is likely due to fat building up within the muscle tissue, rather than the muscle itself growing stronger. These differences strongly suggest that the body's biological response to diseases like Type 2 diabetes may be completely different between men and women.

What Does Your Glute Shape Reveal About Health??

The researchers conclude that the shape of the buttocks, rather than simply its size, is more closely connected to fundamental metabolic changes happening in the body. Because the gluteus maximus is one of the largest muscles in the body, its health plays a crucial role in overall metabolic health.

These findings suggest that tracking gluteal muscle shape could potentially become a new way to monitor metabolic health and disease risk.