A 'Tired' Immune System Could Be A Latent Trigger For Parkinson’s Disease

Updated Mar 1, 2025 | 09:25 AM IST

SummaryParkinson’s disease affects over 10 million people worldwide, with 60,000 new cases diagnosed annually in the U.S. Research suggests immune system exhaustion and chronic inflammation may contribute to neurodegeneration in Parkinson’s patients.
Is A 'Tired' Immune System The Hidden Trigger For Parkinson’s Disease?

The COVID-19 pandemic may be over, but our immune systems are still feeling the impact. After years of battling constant viral threats, from COVID-19 to seasonal flu and other infections, our body’s defense system is exhausted. Many people continue to experience lingering inflammation, frequent illnesses, and slower recovery times. This extended state of immune stress has compromised us further to chronic illness, including autoimmune diseases and even neurodegenerative diseases such as Parkinson's. So why is our immune system still in trouble? And how do we give it its power back? Understanding immune exhaustion is the beginning of rebuilding our body's natural immunity.

A weakened immune system makes people more susceptible to disease, mental illnesses, and even sleep disorders. Now, new research indicates that immune system depletion may play an important role in the onset of Parkinson's disease, a degenerative neurologic disorder that compromises movement and cognition.

Role of Inflammation in Parkinson's Disease

Dysfunctional immune response is a leading cause of long-standing inflammation within the body, that has been found to contribute towards a multitude of conditions, including cardiovascular conditions, diabetes, depression, and neurodegenerative diseases such as Alzheimer's.

As people age, their immune system naturally becomes less effective. This deterioration, referred to as immune exhaustion, may be a key contributor to the onset and progression of Parkinson’s disease. Rebecca Wallings, a Parkinson’s Foundation Launch Award grant recipient and senior postdoctoral fellow at the University of Florida, believes that an accumulation of exhausted immune cells could be driving neurodegeneration in Parkinson’s patients.

How a Tired Immune System Might Affect Parkinson's?

Parkinson's disease is most commonly linked with the degeneration and loss of dopaminergic neurons—motor nerve cells that produce dopamine, an essential neurotransmitter for movement. While researchers have long suspected inflammation is involved in this neurodegeneration, the mechanisms are not yet well understood.

Wallings' study is on immune cell exhaustion, a process by which aging immune cells fail to control immune responses effectively. Her research indicates that instead of dampening inflammation in Parkinson's patients, attempts should be made to rejuvenate the immune system to regain its functionality.

Energy Deficiency in Immune Cells

One of the major findings of Wallings' work is the function of mitochondrial impairment in immune cell exhaustion. Mitochondria are commonly called the powerhouses of cells, as they are vital for generating energy. As mitochondria age and become inefficient, immune cells fail to function well, potentially accelerating neurodegeneration in Parkinson's disease.

Wallings has found that mutations in the LRRK2 gene, a recognized genetic risk factor for Parkinson's disease, are linked with defective mitochondrial function and immune cell exhaustion. Her current work includes testing various therapeutic approaches to restore mitochondrial function in immune cells with the potential to enhance the immune system and potentially prevent or treat Parkinson's disease.

Will Rejuvenating the Immune System Help in Treatment?

For decades, the standard practice in treating Parkinson's has been to suppress brain inflammation. Yet Wallings' work indicates that instead of slowing down immune responses, restoring the immune system could be a more successful strategy. By addressing mitochondrial impairment and immune resilience, researchers can potentially reverse or slow down Parkinson's disease.

Wallings is now looking into how to rejuvenate immune cells by fixing mitochondria. She studies immune cells from patients with Parkinson's as well as from healthy subjects and performs experiments on animal models to determine if rejuvenation of the immune system could result in improved disease outcomes.

Lifestyle Factors That May Affect Parkinson's Risk

While there is no cure for Parkinson's disease, some lifestyle adjustments may decrease the chances of developing the illness. Since neurodegenerative diseases are associated with chronic inflammation and immune dysfunction, developing habits that enhance immune function might prove helpful.

Diet: There is evidence to suggest that eating in accordance with the Mediterranean or MIND diets, both high in antioxidants, healthy fats, and anti-inflammatory foods, can encourage brain wellness and reduce Parkinson's risk.

Avoiding Dangerous Substances: Restricting alcohol and nicotine use can maintain a robust immune system and suppress inflammation.

Reducing Stress: Chronic stress weakens immune function, so methods such as meditation, exercise, and sufficient sleep can lead to improved overall well-being.

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World Allergy Day: Hidden Allergy Triggers At Home You May Be Overlooking

Updated Jul 8, 2026 | 05:00 PM IST

SummaryThe experts cautioned that chronic allergies should not be dismissed as a minor inconvenience, as they can affect sleep, respiratory health, and overall quality of life. They recommended consulting a healthcare professional if allergy symptoms persist for several weeks or throughout the year.
World Allergy Day: Hidden Allergy Triggers at Home You May Be Overlooking

Credit: iStock

While many people blame pollen or changing weather for their allergies, health experts say hidden allergens inside the home may be just as responsible. On the occasion of World Allergy Day on July 8, doctors highlighted that dust mites, mold, pet proteins, and household products are among the often-overlooked triggers that can affect indoor air quality and contribute to persistent allergy symptoms.

They also cautioned that chronic allergies should not be dismissed as a minor inconvenience, as they can affect sleep, respiratory health, and overall quality of life.

What Is A Chronic Allergy?

Dr. Sanjiv Dang, ENT & Allergy Specialist, Apollo Hospitals, Delhi, told HealthandMe that allergy symptoms lasting for weeks, months, or throughout the year may indicate chronic allergies and should not be ignored.

He explained that "allergies occur when the immune system overreacts to substances such as dust mites, pollen, mold, pet dander, or certain foods, releasing histamine". This can lead to symptoms including sneezing, nasal congestion, a runny nose, itchy eyes, and throat irritation.

Hidden Allergens Go Beyond Pollen

Also read: UK Met Office Warns of 'Pollen Bomb': What Hay Fever Patients Need to Know

Prof. (Dr.) Dwaipayan Mukherjee, Consultant ENT Surgeon, Kolkata, told HealthandMe that flower pollen is often blamed for seasonal allergies, but it is usually not the main culprit because its grains are larger and less likely to remain airborne. Instead, he said most seasonal allergies are caused by microscopic airborne pollen from grasses, weeds, and trees.

Dr. Mukherjee, also the Past President of the Association of Otolaryngologists of India (AOI), added that homes can also harbor numerous microscopic allergens that negatively affect indoor air quality. Common triggers include:

  • Dust Mites
These microscopic organisms thrive in mattresses, bedding, carpets, curtains, and upholstered furniture, and their presence depends more on warmth, humidity, and skin flakes than on how clean a home appears.

  • Mold
Found in damp areas such as bathrooms, kitchens, basements, and laundry rooms, it releases airborne spores that can cause sneezing, nasal congestion, coughing, and eye irritation. Poor ventilation and excess moisture can make the problem worse.

  • Pet Proteins
Pet allergies are also frequently misunderstood. Dr. Mukherjee explained that pet fur is rarely the main cause of allergic reactions. Instead, proteins found in an animal's skin cells, saliva, and urine trigger symptoms and can remain suspended in the air or settle on furniture, clothing, and bedding.

    Household Products and Indoor Plants

Cleaning sprays, air fresheners, scented candles, and similar products may emit compounds that irritate sensitive airways and worsen allergy symptoms despite creating the impression of a cleaner environment.

Indoor plants can also become a source of allergens if mold develops in damp potting soil or if certain plants release pollen. Outdoor pollen from trees, grasses, and weeds can also enter homes on clothing, shoes, and hair before settling on indoor surfaces, the experts said.

How Persistent Allergies Affect Health

Read More: New HIV Vaccine Produces Powerful Virus-Fighting Antibodies; Human Trials Begin

Dr. Dang said chronic allergies are more than just a runny nose. Persistent nasal congestion can disrupt sleep, leading to snoring, frequent awakenings, daytime fatigue, poor concentration, reduced productivity, and mood changes.

He added that ongoing allergic inflammation can affect both the upper and lower airways. People with chronic allergies are at a higher risk of developing asthma, while those who already have asthma may experience worsening symptoms such as coughing, wheezing, chest tightness, and shortness of breath.

Chronic allergies can also block normal sinus drainage, increasing the risk of recurrent sinus infections. Facial pressure, headaches, post-nasal drip, persistent congestion, and a reduced sense of smell may all indicate allergy-related sinus problems.

How To Prevent Chronic Allergies

The experts advised relying solely on over-the-counter medications, saying they may provide temporary relief without addressing the underlying cause. They noted that prolonged use of certain nasal decongestant sprays can even worsen congestion over time, and also recommended consulting a healthcare professional if allergy symptoms persist for several weeks or throughout the year.

To help manage chronic allergies, the experts recommended:

  • Improving ventilation indoors.
  • Controlling indoor humidity.
  • Using HEPA air cleaners.
  • Cleaning the home regularly.
  • Eliminate excess moisture.
  • Identifying and reducing exposure to allergy triggers.
  • Controlling mold growth indoors.

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Challenge Your Brain To Keep It Young: New Study Says Learning Another Language Can Help

Updated Jul 8, 2026 | 11:47 AM IST

SummaryA new study says learning new languages requires attention, memory, problem-solving and cognitive control, all of which help in keeping the brain younger.
Learning Another Language May Help Slow Brain Ageing

Credit: AI

Learning a second or even a third language may do more than expand your communication skills. According to a new study presented at the Federation of European Neuroscience Societies (FENS) Forum 2026 in Barcelona, learning a new language could also help keep your brain younger as you age.

The findings of the study say that people who speak multiple languages have brains that appear biologically younger than those who speak only one language. The research added to the growing evidence that multilingualism has a beneficial effect on healthy cognitive ageing.

About The Study

To investigate how language affects the ageing brain, researchers analysed brain activity in adults living in Spain's multilingual Basque region.

They used magnetoencephalography (MEG), a non-invasive brain imaging technique that records the brain's electrical activity, along with artificial intelligence (AI) to ascertain each participant's brain age.

Rather than relying on a person's actual age, the AI model assessed how well different regions of the brain communicated with one another, a key marker that normally weakens with age.

Researchers first trained the AI using brain scans from 728 adults with varying language abilities before validating the findings in an independent group of 144 participants.

Read more: Normal Ageing or Alzheimer's? Doctors Explain Six Key Differences to Watch For

The results revealed an association between multilingualism and a younger-looking brain. Compared with people who spoke only one language, bilingual participants had brains that appeared around six years younger. Those who spoke three languages had brains that looked approximately seven years younger, while participants fluent in four languages had brains that appeared up to 13 years younger.

Researcher Lucia Amoruso, deputy scientific director at the Basque Center on Cognition, Brain and Language in San Sebastián, Spain, said, “In simple terms, people who spoke more languages tended to have brains that looked younger than expected for their chronological age.”

The researchers also found that language proficiency mattered. People who learned additional languages earlier in life and became more fluent showed even greater differences in brain age.

Is Multilingualism The Key To Keep Your Brain Younger?

Scientists believe speaking multiple languages provides the brain with a constant mental workout. Regularly switching between languages requires attention, memory, problem-solving and cognitive control, all of which strengthen the neural networks involved in thinking and decision-making.

This exercise may help maintain stronger communication between brain regions, increasing the brain's resilience against age-related decline.

While the team considered factors like age, sex, and education, multilingual individuals may also be more likely to engage in other habits that are beneficial for the brain.

Although the findings are encouraging, the researchers say that the study does not prove that learning another language directly slows brain ageing or prevents dementia. Experts say further long-term studies are needed to determine whether multilingualism can reduce the risk of neurodegenerative diseases such as Alzheimer's disease.

Despite the need for more research, scientists say the findings offer another compelling reason to learn a new language. Whether through formal classes, language-learning apps or everyday conversations, developing language skills could provide meaningful mental stimulation throughout life.

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The New Chapter After Cancer: Focusing On Wellness And Quality Of Life

Updated Jul 8, 2026 | 10:00 AM IST

SummaryThe goal is no longer to eliminate cancer cells, but to create a life that feels fulfilling and meaningful. Survivors are encouraged to focus on three things treatment itself cannot provide: strength, joy, and a renewed sense of control.
The New Chapter After Cancer: Focusing On Wellness And Quality Of Life

Credit: iStock

Completing cancer treatment is often imagined as the moment life returns to normal. The final chemotherapy session ends, follow-up scans show encouraging results, and the long-awaited words, “You’re in remission,” bring immense relief. Family and friends celebrate the milestone, expecting life to pick up where it left off.

Yet for many survivors, the end of treatment marks the beginning of a different journey. The hospital visits may become less frequent, but new questions often take their place. Will energy levels ever return? Is it normal to still feel anxious before every check-up? How does one rebuild a life that has been profoundly changed by illness?

Life After Cancer

Life after cancer is not simply about surviving; it is about learning to live well again. This phase is an opportunity to focus not only on physical recovery but also on emotional healing, meaningful relationships, and rediscovering a sense of purpose. Survivorship is not defined by the absence of disease alone; it is measured by the quality of life that follows.

During treatment, every decision revolves around cancer. Appointments, medications, scans, and side effects dominate daily life. Once treatment ends, the focus gradually shifts from fighting the disease to rebuilding health and well-being. This transition, often referred to as survivorship care, is about moving from crisis management to long-term wellness.

The goal is no longer simply to eliminate cancer cells, but to create a life that feels fulfilling and meaningful. Survivors are encouraged to focus on three things treatment itself cannot provide: strength, joy, and a renewed sense of control.

Quality of life after cancer extends far beyond follow-up scans and medical reports. It encompasses physical, emotional, social, and practical well-being. Paying attention to each of these areas can help survivors thrive rather than merely cope.

Physical Recovery After Cancer Treatment

Physically, the body often needs time to recover from the effects of chemotherapy, surgery, radiation, or hormone therapy. Fatigue, reduced stamina, neuropathy, weight changes, and muscle loss are common challenges. Regular movement plays a critical role in recovery.

Experts recommend at least 150 minutes of moderate exercise each week, along with two sessions of strength training to rebuild muscle and improve energy levels. For survivors experiencing lymphedema, pelvic floor concerns, or mobility limitations, working with a physiotherapist can provide targeted support. A balanced diet rich in protein also helps restore strength and independence.

Emotional Recovery Post Cancer Treatment

Emotional recovery deserves equal attention. Fear of recurrence, anxiety before follow-up scans, survivor's guilt, and grief for the life that existed before diagnosis are all common experiences.

These feelings are not symptoms of weakness; they are natural responses to a life-changing event. Seeking support from a psycho-oncologist, counsellor, or support group can significantly improve emotional well-being. Even simple practices such as mindfulness, journaling, or spending a few quiet minutes each day focusing on the present moment can help reduce stress and build resilience.

Cancer's Impact On Relationships And Financial Pressures

Cancer can also reshape relationships. Some friendships may change, while family members and partners may continue adjusting to roles they adopted during treatment.

Open conversations about needs, limitations, and expectations can help strengthen these relationships. Reconnecting with supportive people, participating in survivor communities, or mentoring newly diagnosed patients can create a sense of belonging and purpose. Healing is often easier when it happens in the company of others.

Practical concerns can persist long after treatment ends. Financial pressures, career interruptions, insurance challenges, and concerns about returning to work can affect overall well-being. Seeking guidance from social workers, financial counsellors, or patient support organizations can help survivors navigate these issues. In India, government initiatives such as Ayushman Bharat, state-level healthcare schemes, and various non-governmental organizations may offer valuable assistance.

Challenges Of Survivors

One of the greatest challenges survivors face is the expectation of returning to the person they were before cancer. However, recovery is not about going back; it is about moving forward. A new normal often emerges, the one shaped by deeper self-awareness, healthier boundaries, and a greater appreciation for everyday moments.

Many long-term survivors describe experiencing what experts call post-traumatic growth. They report stronger relationships, clearer priorities, and a renewed sense of purpose. They become more intentional about how they spend their time and energy, recognizing that health and meaningful experiences deserve as much attention as professional achievements.

The first year after treatment is a time of adjustment. Establishing healthy routines, gradually resuming work and hobbies, staying consistent with follow-up appointments, and setting goals unrelated to cancer can help restore confidence. Whether it is taking a short trip, learning a new skill, planting a garden, or simply enjoying time with loved ones, these experiences remind survivors that life extends beyond medical milestones.

Risk of New Symptoms

At the same time, wellness does not mean ignoring new symptoms. Persistent pain, unexplained weight loss, unusual bleeding, ongoing fatigue, or symptoms of anxiety and depression that last more than two weeks should be discussed with a healthcare provider. Survivorship care is an essential part of recovery, and seeking help when needed is a sign of self-care, not concern.

Cancer may have changed the course of life, but it does not define its future. The chapter after treatment may look different from the one that came before, but it can still be rich with meaning, connection, and hope.

The treatment phase was about fighting to survive. The next phase is about discovering what makes life meaningful again. It is about protecting quality of life with the same determination that carried survivors through treatment—because surviving cancer is not only about living longer, but about living well.

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