The COVID-19 pandemic may be over, but our immune systems are still feeling the impact. After years of battling constant viral threats, from COVID-19 to seasonal flu and other infections, our body’s defense system is exhausted. Many people continue to experience lingering inflammation, frequent illnesses, and slower recovery times. This extended state of immune stress has compromised us further to chronic illness, including autoimmune diseases and even neurodegenerative diseases such as Parkinson's. So why is our immune system still in trouble? And how do we give it its power back? Understanding immune exhaustion is the beginning of rebuilding our body's natural immunity.

A weakened immune system makes people more susceptible to disease, mental illnesses, and even sleep disorders. Now, new research indicates that immune system depletion may play an important role in the onset of Parkinson's disease, a degenerative neurologic disorder that compromises movement and cognition.

Role of Inflammation in Parkinson's Disease

Dysfunctional immune response is a leading cause of long-standing inflammation within the body, that has been found to contribute towards a multitude of conditions, including cardiovascular conditions, diabetes, depression, and neurodegenerative diseases such as Alzheimer's.

As people age, their immune system naturally becomes less effective. This deterioration, referred to as immune exhaustion, may be a key contributor to the onset and progression of Parkinson’s disease. Rebecca Wallings, a Parkinson’s Foundation Launch Award grant recipient and senior postdoctoral fellow at the University of Florida, believes that an accumulation of exhausted immune cells could be driving neurodegeneration in Parkinson’s patients.

How a Tired Immune System Might Affect Parkinson's?

Parkinson's disease is most commonly linked with the degeneration and loss of dopaminergic neurons—motor nerve cells that produce dopamine, an essential neurotransmitter for movement. While researchers have long suspected inflammation is involved in this neurodegeneration, the mechanisms are not yet well understood.

Wallings' study is on immune cell exhaustion, a process by which aging immune cells fail to control immune responses effectively. Her research indicates that instead of dampening inflammation in Parkinson's patients, attempts should be made to rejuvenate the immune system to regain its functionality.

Energy Deficiency in Immune Cells

One of the major findings of Wallings' work is the function of mitochondrial impairment in immune cell exhaustion. Mitochondria are commonly called the powerhouses of cells, as they are vital for generating energy. As mitochondria age and become inefficient, immune cells fail to function well, potentially accelerating neurodegeneration in Parkinson's disease.

Wallings has found that mutations in the LRRK2 gene, a recognized genetic risk factor for Parkinson's disease, are linked with defective mitochondrial function and immune cell exhaustion. Her current work includes testing various therapeutic approaches to restore mitochondrial function in immune cells with the potential to enhance the immune system and potentially prevent or treat Parkinson's disease.

Will Rejuvenating the Immune System Help in Treatment?

For decades, the standard practice in treating Parkinson's has been to suppress brain inflammation. Yet Wallings' work indicates that instead of slowing down immune responses, restoring the immune system could be a more successful strategy. By addressing mitochondrial impairment and immune resilience, researchers can potentially reverse or slow down Parkinson's disease.

Wallings is now looking into how to rejuvenate immune cells by fixing mitochondria. She studies immune cells from patients with Parkinson's as well as from healthy subjects and performs experiments on animal models to determine if rejuvenation of the immune system could result in improved disease outcomes.

Lifestyle Factors That May Affect Parkinson's Risk

While there is no cure for Parkinson's disease, some lifestyle adjustments may decrease the chances of developing the illness. Since neurodegenerative diseases are associated with chronic inflammation and immune dysfunction, developing habits that enhance immune function might prove helpful.

Diet: There is evidence to suggest that eating in accordance with the Mediterranean or MIND diets, both high in antioxidants, healthy fats, and anti-inflammatory foods, can encourage brain wellness and reduce Parkinson's risk.

Avoiding Dangerous Substances: Restricting alcohol and nicotine use can maintain a robust immune system and suppress inflammation.

Reducing Stress: Chronic stress weakens immune function, so methods such as meditation, exercise, and sufficient sleep can lead to improved overall well-being.

Men who consume higher amounts of dietary nitrite may have a greater risk of colorectal cancer, particularly the type affecting the distal colon, according to a new study published in the Journal of the National Cancer Institute.

The study followed 82,009 middle-aged and older adults in Sweden for more than two decades and identified 3,170 cases of colorectal cancer.

Researchers found that men in the highest category of nitrite intake had a 23% higher risk of colorectal cancer overall compared with those in the lowest category. The strongest association was for for distal colon cancer, where the risk was 50% higher.

The findings were not seen in women, and dietary nitrate was not associated with colorectal cancer in either men or women.

More About The Study

Researchers from Karolinska Institutet in Sweden used dietary information collected in 1997 and updated in 2009 and 2019. They linked this information with Sweden's cancer registry to identify colorectal cancer cases through 2022.

Rather than relying only on participants' diet at the beginning of the study, researchers used repeated measurements to capture changes in nitrite and nitrate intake over time. Among men, the highest versus lowest levels of nitrite consumption were associated with a hazard ratio of 1.23 for colorectal cancer. For distal colon cancer, the hazard ratio rose to 1.50.

Also read: How Genetic and Genomic Testing Can Help Women Make Smarter Cancer Decisions

Difference Between Nitrite And Nitrate

Nitrite and nitrate are related compounds, but they are found in different foods and behave differently in the body. Nitrate occurs naturally in vegetables, particularly leafy greens, as well as drinking water. Nitrite is also naturally present in some foods but is commonly used as a preservative in processed meat and other animal products.

The researchers found no association between dietary nitrate and colorectal cancer, making the distinction particularly important.

Also read: Moderna-Merck’s Personalized mRNA Vaccine: Ushering In A New Era In Cancer Care?

Why Nitrite Could Be A Concern For Cancer Risk?

A possible explanation involves N-nitroso compounds, which can form when nitrate and nitrite undergo chemical reactions in the body. Some N-nitroso compounds are known to be carcinogenic in animals.

The researchers saw that previous studies have also investigated possible links between nitrite exposure and cancers of the gastrointestinal tract. However, the exact biological mechanism behind the association observed in this study remains uncertain.

The researchers also found that the association was specific to men, and they said the reason for this difference is unclear.

Sex Difference Needs More Investigation

The authors noted that the higher risk associated with nitrite intake was confined to men and suggested several possible biological explanations, including differences in oxidative stress and other sex-specific factors.

But they stressed that these mechanisms have not been established as the reason for the finding. The study concludes that further research should examine nitrite and colorectal cancer separately in men and women and.

The study was observational, meaning researchers identified an association between dietary nitrite intake and cancer risk but could not prove a direct cause and effect relationship.

For people who work, laptops and computers are something we use every day. Sitting in front of a screen for hours can be bad for your neck and spine. When you sit and use your laptop the way you position yourself can hurt your neck over time.

This is true even when you are just scrolling on your phone. Keeping your head bent for a long time can put stress on the muscles and joints in your neck.

How Looking Down At Screens Strains Your Neck

The problem is not the laptop itself but how we use it. Many people spend hours looking down at a screen without realizing it. This can cause muscle fatigue, stiffness, headaches and neck pain that will not go away.

Your neck is meant to support your head and let you move it around. When you keep your head tilted forward for hours the muscles in your neck have to work hard to keep it that way. Over time this can cause discomfort. Make it harder to move your neck.

If you sit with posture it can also affect the normal curve of your neck. Poor posture may not cause spinal problems on its own but it can cause wear and discomfort. This is especially true for people who already have neck or spine problems.

Also read: The Hidden Health Risk of Sitting for Long Hours: What Young Professionals Need to Know

Small Workspace Changes Can Reduce Neck Strain

One simple way to reduce strain on your neck is to make your workspace more comfortable. Your laptop or monitor should be at eye level so you do not have to look down all the time. Your back should be. Your arms should be comfortable too. Keep your feet flat on the floor. Do not sit still for too long.

It is also important to move regularly. Of sitting for hours get up and move every 30-40 minutes. Stand up walk around and move your neck and shoulders gently. This can help prevent stiffness and reduce strain on your neck. Your neck is meant to move not be stuck in one position for hours.

When Neck Pain Should Not Be Ignored?

If your neck is stiff after a day, it may feel better with rest and better posture. If the pain gets worse or does not go away, you should see a doctor. If you have pain in your arm or if your arm feels numb tingling or weak you should see a doctor too.

To protect your neck, you do not have to make changes. Just make small adjustments to how you sit and use your laptop and move around more during the day. This can make using your laptop more comfortable. Reduce strain, on your neck and spine.

By Dr. Zahir Abbas Merchant, Consultant Spine Surgeon, Saifee Hospital, Mumbai

Delhi has issued a public health advisory amid a sharp rise in H1N1, commonly known as swine flu, cases. Health authorities urging residents to follow respiratory hygiene, avoid crowded places and seek medical advice if flu-like symptoms develop.

The national capital has reported more than 1,777 H1N1 cases so far this year, including 114 new infections recorded on August 20 alone, according to the latest health department data. Overall, Delhi has reported more than 2,300 Influenza-A cases in 2026.

The sudden surge has prompted the Centre and Delhi authorities to step up surveillance and hospital preparedness. Health officials have also stressed that people should not panic but take necessary precautions to avoid getting sick.

Delhi Sees A Sharp Rise In H1N1 Cases

According to health department, Delhi had recorded 2,392 Influenza-A cases by August 21, of which 1,777 were H1N1. The tally also included H1 and H3 infections and other Influenza-A strains.

The current number is significantly higher than the corresponding period last year. Public health experts have also described some of the H1N1 cases being seen this season as relatively severe.

Dr Chandrakant Lahariya, a public health expert, said H1N1 is not a new subtype and has been known for years, but the current surge needs to be taken seriously.

Also read: Delhi H1N1 Cases Rise To 1,777: Patients Reporting Diarrhea, Muscle Pain, Drop In Oxygen Levels, Say Doctors

Humid Weather Could Be A Major Factor

Doctors have linked the increase to the seasonal pattern of respiratory infections during the monsoon, when humidity, changing temperatures and increased indoor contact can facilitate the spread of respiratory viruses.

Dr Neetu Jain, senior consultant in pulmonary, critical care and sleep medicine at PSRI Hospital, told PTI, “H1N1 cases are particularly high in Delhi-NCR this year.”

She also said the number of cases was reported to be around six times higher than previous years and noted that high temperatures and humidity may contribute to the increase in flu and other viral infections.

Common Symptoms

H1N1 infection can mimic other viral respiratory illnesses. Common symptoms include:

• Fever
• Cough
• Sore throat
• Runny or blocked nose
• Headache
• Body aches
• Chills
• Fatigue and weakness

Some people recover without complications, but influenza can become serious, particularly in young children, older adults, pregnant women and people with weak immune systems.

Difficulty in breathing, chest pain, drowsiness, low blood pressure, bluish discolouration or worsening of an existing medical condition are among warning signs that need urgent medical attention.

Also read: Human H1N2v Swine Flu Case Detected In China: Should You Worry?

Doctors Advise Against Self-Medication

With flu cases rising, doctors are also urging people not to assume that every fever or cough is H1N1 and start medicines without medical advice.

Dr Jain described H1N1 as a “fairly treatable illness”, while noting that it can become serious in vulnerable people. Antiviral medicines may be prescribed in appropriate cases, along with supportive treatment.

The Delhi government's advisory recommends several basic measures to reduce transmission. People are being urged to wear masks in crowded places, cover their mouth and nose while coughing or sneezing, wash their hands frequently and avoid close contact with people showing respiratory symptoms.

Residents have also been advised not to touch their eyes, nose or mouth unnecessarily and to avoid spitting in public places.

People who develop flu-like symptoms should stay away from others where possible and seek medical advice, particularly if symptoms become severe.

Strenghtening Healthcare System

Authorities have also increased monitoring across the healthcare system. Thirty-five hospitals are under special surveillance, while referral laboratories at AIIMS and the National Centre for Disease Control (NCDC) are available for testing and confirmation.

Hospitals and district health authorities have been asked to strengthen monitoring of influenza-like illness, severe respiratory infections and COVID-19.

Union Health Minister JP Nadda has also reviewed Delhi's preparedness amid the rise in H1N1 cases, with authorities instructed to focus on surveillance, early detection and timely treatment.