The COVID-19 pandemic may be over, but our immune systems are still feeling the impact. After years of battling constant viral threats, from COVID-19 to seasonal flu and other infections, our body’s defense system is exhausted. Many people continue to experience lingering inflammation, frequent illnesses, and slower recovery times. This extended state of immune stress has compromised us further to chronic illness, including autoimmune diseases and even neurodegenerative diseases such as Parkinson's. So why is our immune system still in trouble? And how do we give it its power back? Understanding immune exhaustion is the beginning of rebuilding our body's natural immunity.

A weakened immune system makes people more susceptible to disease, mental illnesses, and even sleep disorders. Now, new research indicates that immune system depletion may play an important role in the onset of Parkinson's disease, a degenerative neurologic disorder that compromises movement and cognition.

Role of Inflammation in Parkinson's Disease

Dysfunctional immune response is a leading cause of long-standing inflammation within the body, that has been found to contribute towards a multitude of conditions, including cardiovascular conditions, diabetes, depression, and neurodegenerative diseases such as Alzheimer's.

As people age, their immune system naturally becomes less effective. This deterioration, referred to as immune exhaustion, may be a key contributor to the onset and progression of Parkinson’s disease. Rebecca Wallings, a Parkinson’s Foundation Launch Award grant recipient and senior postdoctoral fellow at the University of Florida, believes that an accumulation of exhausted immune cells could be driving neurodegeneration in Parkinson’s patients.

How a Tired Immune System Might Affect Parkinson's?

Parkinson's disease is most commonly linked with the degeneration and loss of dopaminergic neurons—motor nerve cells that produce dopamine, an essential neurotransmitter for movement. While researchers have long suspected inflammation is involved in this neurodegeneration, the mechanisms are not yet well understood.

Wallings' study is on immune cell exhaustion, a process by which aging immune cells fail to control immune responses effectively. Her research indicates that instead of dampening inflammation in Parkinson's patients, attempts should be made to rejuvenate the immune system to regain its functionality.

Energy Deficiency in Immune Cells

One of the major findings of Wallings' work is the function of mitochondrial impairment in immune cell exhaustion. Mitochondria are commonly called the powerhouses of cells, as they are vital for generating energy. As mitochondria age and become inefficient, immune cells fail to function well, potentially accelerating neurodegeneration in Parkinson's disease.

Wallings has found that mutations in the LRRK2 gene, a recognized genetic risk factor for Parkinson's disease, are linked with defective mitochondrial function and immune cell exhaustion. Her current work includes testing various therapeutic approaches to restore mitochondrial function in immune cells with the potential to enhance the immune system and potentially prevent or treat Parkinson's disease.

Will Rejuvenating the Immune System Help in Treatment?

For decades, the standard practice in treating Parkinson's has been to suppress brain inflammation. Yet Wallings' work indicates that instead of slowing down immune responses, restoring the immune system could be a more successful strategy. By addressing mitochondrial impairment and immune resilience, researchers can potentially reverse or slow down Parkinson's disease.

Wallings is now looking into how to rejuvenate immune cells by fixing mitochondria. She studies immune cells from patients with Parkinson's as well as from healthy subjects and performs experiments on animal models to determine if rejuvenation of the immune system could result in improved disease outcomes.

Lifestyle Factors That May Affect Parkinson's Risk

While there is no cure for Parkinson's disease, some lifestyle adjustments may decrease the chances of developing the illness. Since neurodegenerative diseases are associated with chronic inflammation and immune dysfunction, developing habits that enhance immune function might prove helpful.

Diet: There is evidence to suggest that eating in accordance with the Mediterranean or MIND diets, both high in antioxidants, healthy fats, and anti-inflammatory foods, can encourage brain wellness and reduce Parkinson's risk.

Avoiding Dangerous Substances: Restricting alcohol and nicotine use can maintain a robust immune system and suppress inflammation.

Reducing Stress: Chronic stress weakens immune function, so methods such as meditation, exercise, and sufficient sleep can lead to improved overall well-being.

1 in every 8 child in Kolkata school between the age of 12 to 16 is obese. A new study conducted in Kolkata schools by a global obesity awareness organization revealed this data. Wednesday, the same day as Holi in India, was also the World Obesity Day. In Kolkata, the issue is concerning, especially when children are at the center of it. The Howrah bridge also lit with blue and yellow lights, the colors to symbolize obesity awareness.

What Did The Study Reveal About Obese Children?

An initiative by METTA Dana Foundation, a global academic outreach organization with its focus on childhood obesity revealed the rising case of childhood obesity in Kolkata. "Childhood obesity is rising rapidly, with the prevalence among school-aged children increasing from 4% in 1975 to almost 20% in 2022," said Debashis Basu, endocrinologist and chairman of METTA Dana Foundation. This is seen as a five-fold increase over five decades.

Basu further said, "The rise is sharpest in low-and-middle-income countries like India and Bangladesh. Childhood obesity often continues into adulthood, increasing the risk of serious non-communicable diseases, such as diabetes, heart disease and certain cancers." Basu also said that 13 per cent of such cancers are related to childhood obesity.

He said that early signs of chronic diseases are already appearing in children. He also noted that around "a fourth of Kolkata's children are diabetic or are in a pre-diabetic stage".

Obesity In Young People

Globally, as per a Lancet study, more than half of all adults and a third of children and adolescents will become overweight by 2050. The study also notes that obesity is becoming a bigger concern and it could impact around 21.8 crore men and 23.1 crore women in India.

In fact, India is projected to have world's second highest number of obese kids and adolescents, aged between five and 14 years. This means around 16 million boys and 14 million girls could be overweight.

One of the biggest challenges of being overweight is diabetes, as Basu also noted. In a previous conversation with Health and Me Dr Mayank Lodha Seth, chief pathologist at Redcliffe Labs, noted that diabetes is no longer a disease of aging, young people, including teenagers too are affected.

Also Read: Diabetes No Longer A Disease Of Aging; Four Things Youth Should Know About It, According To Doctor

"We took this initiative to revive it [World Obesity Day] this year with support from National Institute of Nutrition. India is beginning to face the triple burden of malnutrition, stunting and wasting, micronutrient deficiencies, and obesity- often coexisting in the same family or the same person in various stages," said Basu.

Why Is India Facing A Crisis In Youth Obesity?

According to UNICEF’s Child Nutrition Global Report 2025, obesity, for the first time, surpassed underweight globally as the most common form of malnutrition among school-aged children and adolescents.

According to the National Family Health Survey (NFHS) data, India is witnessing a rapid surge in overweight and obesity among under-five children under five, with prevalence rising by 127 per cent (from 1.5 per cent to 3.4 per cent between NFHS 3 (2005-06) and NFHS 5 (2019-21). Similarly, adolescent girls and boys have seen an increase in overweight and obesity of 125 per cent (from 2.4 per cent to 5.4 per cent) and 288 per cent (from 1.7 per cent to 6.6 per cent) respectively.

A recent child nutrition report points to a worrying shift in the way young people in India eat. Fast foods, ultra-processed snacks, and sugary drinks that are high in fat, salt, and sugar are steadily replacing fruits, vegetables, and traditional home-cooked meals. These choices are not always driven by taste alone. Easy availability and aggressive marketing campaigns aimed at children and teenagers are increasingly shaping what they want to eat.

Early-life factors are also playing a role in the rising numbers. Poor maternal nutrition during pregnancy, inadequate infant feeding practices, and low rates of exclusive breastfeeding can influence a child’s long-term health and metabolism. Social and gender norms add another layer to the problem. In many households, adolescent girls and women still eat last and often the least, which can affect nutritional balance early in life and contribute to unhealthy patterns later.

At the same time, lifestyles among young people are rapidly changing. The growing consumption of ultra-processed foods and sugar-sweetened beverages is being combined with lower levels of physical activity. Children and teenagers today spend more time on screens, whether for schoolwork, entertainment, or social media, leaving less time for outdoor play and movement. This shift towards sedentary routines is one of the key reasons obesity is increasing among the younger population.

The environment around food is also changing. Urban areas and even smaller towns are now saturated with packaged and processed food options that are quick, cheap, and heavily promoted. When healthier choices are less visible or less accessible, children and adolescents are more likely to gravitate toward convenient, calorie-dense products.

Data from UNICEF’s U-Report poll, which surveyed adolescents and young adults aged 13 to 24 across 171 countries, highlights the scale of marketing exposure. More than two-thirds of young people said they regularly encounter food advertisements. In the week before the poll, 75 per cent reported seeing ads for sugary drinks, fast food, or packaged snacks. Social media was the biggest source of exposure at 52 per cent, followed by the internet at 46 per cent and television at 43 per cent. Not surprisingly, three in five respondents admitted that these advertisements made them want to try the products they saw.

Experts say this constant exposure is shaping dietary habits from an early age. When young people repeatedly see unhealthy foods promoted as fun, trendy, or aspirational, it normalizes those choices.

Selena Gomez recently opened up about being wrongly diagnosed for her mental health issues. The 33-year-old singer said that she was "misdiagnosed" before she ultimately received her bipolar disorder diagnosis.

She, along with her husband appeared on the podcast Friends Keep Secret, and said that she knew something was wrong with her. "I knew something was wrong, but I think I was misdiagnosed," Gomez said. "People were just assuming, and I would try multiple therapists. And that’s why it’s hard. It’s actually really hard when we’re talking about these things. And for me to go get a therapist, all of it is so f***ing complicated."

Going on to explain that finding the right diagnosis and treatments took going through "multiple different people," Gomez emphasized how important it was to remember that "you can’t just give up." Gomez also said she underwent therapies at four different rehabs, which helped her understand her diagnosis - a chronic mental health condition characterized by severe mood swings, alternating between extreme emotional highs and lows.

Therapy Should Not Be Shamed, Says Gomez

Gomez also slammed people who shame the idea of therapy. She said those people are hypocrites. "That's the problem with misconceptions," she said. "The whole hypocrisy of shaming people for therapy or people not understanding it is that it’s just not for you. That’s completely fine, but for me, it finally allowed me to go, ‘Oh, that’s why I handled things the way I handled them. That’s why all the other people were able to get over things so quickly, and I wasn’t.'”

“I would act out of fear, I would act out of love, I would act out of passion,” she added.

What Is Bipolar Disorder?

As per the American Psychiatric Association (APA), bipolar disorders are mental health conditions characterized by periodic, intense emotional states affecting a person's mood, energy and ability to function. APA notes that these periods, lasting from days to weeks, are called mood episodes.

Mood episodes are categorized as manic/hypomanic episodes when the predominant mood is intensely happy or irritable, or depressive episodes, when there is an intensely sad mood or the ability to experience joy or pleasure disappears. People with bipolar disorder generally have periods of neutral mood as well. When treated, people with bipolar disorder can lead full and productive lives.

But Don't Mood Fluctuations Happen To People Without The Disorder?

APA notes that while people without bipolar disorder could also experiences mood fluctuations, they are part of commonly lived experience and typically last hours rather than days. These mood fluctuations are also not accompanied by extreme changes in behavior or changes in functioning, such as difficulties with daily routines and social interactions. Bipolar disorder could also disrupt a person's relationships with loved ones and cause difficulty in working or going to school.

What Causes Bipolar Disorder?

Bipolar disorder usually runs in families, as 80 to 90 per cent of cases come from a relative with bipolar disorder or depression.

Environmental factors such as stress, sleep disruption, and drugs and alcohol may trigger mood episodes in vulnerable people. Though the specific causes of bipolar disorder are unclear, there are both biological factors, including a family history of mood disorders, psychotic disorders, and substance misuse, and environmental factors that increase the risk for bipolar disorder. The average age of onset is in the mid-20s.

This Is Endometriosis, a 2024 intimate, expressive film by Georgie Wileman and Matt Houghton won a BAFTA Award 2026 for Best British Short Film. This 19.27 minute long film shows how Georgie was robbed of her time due to endometriosis. The film sets in present-day narrative with memories from her past.

Endometriosis is a condition, that Georgie notes is often dismissed by many doctors as just "painful periods". However, her film portrays how truly disabling this medical condition. It is a condition in which cell similar to the lining of the uterus or the endometrium, grow outside the uterus. It affects 1 in 10 born with a uterus and could cause pain, often "worse than the last stages of child labour", notes thisiseno.com, the official website of the short film. Around 190 million people worldwide are impacted by the condition, however, what the film points out is how "dangerously underfunded, under researched and misinformed" doctors continue to remain despite the condition being so widespread.

Read: A Woman Lost Her Ovary To Endometriosis Surgery After Receiving An Ultimatum From Gynecologist

A Film That Documents Personal Struggle

Georgie, while accepting the award wore a symbolic blood-red gown. She said, "It was surreal and beautiful. Knowing how much this win would mean to the [endometriosis] community made it an emotional moment."

She points out that it is more than just a "painful period" and that "It is a full body disease. It important for people to understand the severity of the pain – it’s widely considered to be worse than childbirth." What is shocking is that it takes an average of eight to 10 years to be diagnosed.

She shares being "bed-bound for three months" when she was only 13. She said it first got "really bad" and she was not believed for long time. "It took me a long time to even believe myself. I was just so angry at my body for not working."

While she had been in and out of wheelchair, she was not formally diagnosed with endometriosis until she was 26, and then at 29, she was diagnosed with its 'sister disease' adenomyosis. She has undergone seven surgeries for her endometriosis and a hysterectomy for adenomyosis.

Read: Keltie Knight Was Gaslit By Doctors For Years Before Getting A Hysterectomy

In 2020, after years of feeling dismissed by doctors and watching her condition be misunderstood in the media, she decided she had had enough. That frustration pushed her to tell the story herself.

“It began as a photography project,” Wileman says. “And it meant a lot to people because, for the first time, they felt their experiences were being shown truthfully.”

But she soon realized that still images could only go so far. “There’s only so much a photograph can capture,” she adds.

Why Does It Take So Long For An Endometriosis Diagnosis?

A study published in Obstetrics and Gynecology journal looks at the factors of what leads to such a delay in endometriosis diagnosis. Researchers identified that factors include normalization of menstrual pain, the diversity of symptoms, and a lack of training and prompt referrals among healthcare professionals lead to this delay.

At an individual level, the researchers found that many women struggled to tell the difference between “normal” period pain and something more serious. A common belief was that painful periods were simply part of being a woman and had to be endured. As a result, many relied on self-care measures and delayed seeking medical help, which likely pushed back the timeline for an endometriosis diagnosis.

On an interpersonal level, stigma played a powerful role. Menstrual problems were often seen as too private or embarrassing to talk about. At the same time, society’s tendency to normalize period pain meant that symptoms were minimized, both by those experiencing them and by people around them. This silence and normalization further contributed to delayed diagnoses.

Barriers also existed within the healthcare system itself. Some participants said their general practitioners dismissed their concerns or appeared unfamiliar with endometriosis. Healthcare professionals involved in the study acknowledged gaps in their own training and pointed out the lack of clear clinical guidelines for diagnosing the condition.

Doctors also noted that endometriosis symptoms can overlap with other disorders, making it harder to identify. Diagnosis is particularly challenging because there is no simple, noninvasive test that can confirm the condition with certainty. Delays in referrals were common. One contributing factor was the widespread belief that laparoscopic surgery is the only definitive way to diagnose endometriosis. Some healthcare providers also questioned how useful a formal diagnosis would be, which further slowed the process.

Dr Sophie Davenport, a doctor in England who conducted the research as part of her Master of Public Health dissertation, emphasized that the problem is layered and requires solutions at multiple levels.

“The key highlights of the data are that delays to diagnosis exist throughout the journey,” she explained. “We need to address these at different levels — from society understanding what ‘normal’ menstruation looks like and being open about menstrual problems, to clinicians being well educated, up to date on how endometriosis presents and diagnosed, and truly listening when patients say their periods aren’t normal.”