The COVID-19 pandemic may be over, but our immune systems are still feeling the impact. After years of battling constant viral threats, from COVID-19 to seasonal flu and other infections, our body’s defense system is exhausted. Many people continue to experience lingering inflammation, frequent illnesses, and slower recovery times. This extended state of immune stress has compromised us further to chronic illness, including autoimmune diseases and even neurodegenerative diseases such as Parkinson's. So why is our immune system still in trouble? And how do we give it its power back? Understanding immune exhaustion is the beginning of rebuilding our body's natural immunity.

A weakened immune system makes people more susceptible to disease, mental illnesses, and even sleep disorders. Now, new research indicates that immune system depletion may play an important role in the onset of Parkinson's disease, a degenerative neurologic disorder that compromises movement and cognition.

Role of Inflammation in Parkinson's Disease

Dysfunctional immune response is a leading cause of long-standing inflammation within the body, that has been found to contribute towards a multitude of conditions, including cardiovascular conditions, diabetes, depression, and neurodegenerative diseases such as Alzheimer's.

As people age, their immune system naturally becomes less effective. This deterioration, referred to as immune exhaustion, may be a key contributor to the onset and progression of Parkinson’s disease. Rebecca Wallings, a Parkinson’s Foundation Launch Award grant recipient and senior postdoctoral fellow at the University of Florida, believes that an accumulation of exhausted immune cells could be driving neurodegeneration in Parkinson’s patients.

How a Tired Immune System Might Affect Parkinson's?

Parkinson's disease is most commonly linked with the degeneration and loss of dopaminergic neurons—motor nerve cells that produce dopamine, an essential neurotransmitter for movement. While researchers have long suspected inflammation is involved in this neurodegeneration, the mechanisms are not yet well understood.

Wallings' study is on immune cell exhaustion, a process by which aging immune cells fail to control immune responses effectively. Her research indicates that instead of dampening inflammation in Parkinson's patients, attempts should be made to rejuvenate the immune system to regain its functionality.

Energy Deficiency in Immune Cells

One of the major findings of Wallings' work is the function of mitochondrial impairment in immune cell exhaustion. Mitochondria are commonly called the powerhouses of cells, as they are vital for generating energy. As mitochondria age and become inefficient, immune cells fail to function well, potentially accelerating neurodegeneration in Parkinson's disease.

Wallings has found that mutations in the LRRK2 gene, a recognized genetic risk factor for Parkinson's disease, are linked with defective mitochondrial function and immune cell exhaustion. Her current work includes testing various therapeutic approaches to restore mitochondrial function in immune cells with the potential to enhance the immune system and potentially prevent or treat Parkinson's disease.

Will Rejuvenating the Immune System Help in Treatment?

For decades, the standard practice in treating Parkinson's has been to suppress brain inflammation. Yet Wallings' work indicates that instead of slowing down immune responses, restoring the immune system could be a more successful strategy. By addressing mitochondrial impairment and immune resilience, researchers can potentially reverse or slow down Parkinson's disease.

Wallings is now looking into how to rejuvenate immune cells by fixing mitochondria. She studies immune cells from patients with Parkinson's as well as from healthy subjects and performs experiments on animal models to determine if rejuvenation of the immune system could result in improved disease outcomes.

Lifestyle Factors That May Affect Parkinson's Risk

While there is no cure for Parkinson's disease, some lifestyle adjustments may decrease the chances of developing the illness. Since neurodegenerative diseases are associated with chronic inflammation and immune dysfunction, developing habits that enhance immune function might prove helpful.

Diet: There is evidence to suggest that eating in accordance with the Mediterranean or MIND diets, both high in antioxidants, healthy fats, and anti-inflammatory foods, can encourage brain wellness and reduce Parkinson's risk.

Avoiding Dangerous Substances: Restricting alcohol and nicotine use can maintain a robust immune system and suppress inflammation.

Reducing Stress: Chronic stress weakens immune function, so methods such as meditation, exercise, and sufficient sleep can lead to improved overall well-being.

The shape of your gluteus maximus, the largest muscle in your backside, may offer surprising clues about your likelihood of developing diabetes. New research suggests that the contours of this major muscle change with age and health conditions, helping scientists better understand how fitness, muscle health, and metabolism are connected.

Ageing, Weight, and Diabetes: What We Already Know

For years, the NHS has warned that ageing and excess weight increase the risk of developing Type 2 diabetes. However, this new study goes beyond traditional measures, proposing that the shape of the gluteus maximus itself shifts as people age or develop conditions such as osteoporosis or diabetes. These subtle muscular changes could provide valuable information about a person’s metabolic health.

Why the Gluteus Maximus Matters

Researchers from the University of Westminster highlighted that the gluteus maximus plays a key role not just in movement but also in metabolic regulation. Healthy, well-maintained muscles can improve blood sugar control and reduce the burden on organs involved in glucose processing.

Dr Marjola Thanaj, co-author of the study from the university’s Research Centre for Optimal Health, explained, as reported by Independent: “People with higher fitness, as measured by vigorous physical activity and hand grip strength, had a greater gluteus maximus shape, while ageing, frailty and long sitting times were linked to muscle thinning.”

Mapping the Muscle

To understand these differences, researchers used advanced MRI 3D mapping to create a detailed anatomical model of the gluteus maximus. By analyzing more than 61,000 MRI scans from the UK Biobank database, they discovered that the shape, not the size, of the muscle varied significantly between individuals with diabetes and those without it.

What the Study Found

The MRI analysis revealed distinct, sex-specific patterns linked to Type 2 diabetes. Among male participants living with the disease, those classified as “frail” showed widespread muscle shrinkage across the gluteus maximus, indicating a loss of muscle quality and strength.

Women with diabetes, on the other hand, had enlarged muscle shapes — not because of increased muscle strength, but because of fat infiltrating the muscle tissue. This type of fat infiltration often signals declining muscle function and poorer metabolic health.

Dr Thanaj said these patterns underline a crucial point: men and women can experience the same illness in very different biological ways, which may influence diagnosis and treatment strategies in the future.

Why Maintaining Muscle Mass Matters

Beyond appearance or strength, muscle health is essential for long-term wellbeing. Maintaining muscle mass supports blood sugar regulation, reduces the risk of cardiovascular disease, and lowers the likelihood of developing fatty liver disease, all conditions closely linked to metabolic health.

Professor Louise Thomas, senior author of the study, told The Times: “Maintaining muscle mass as we age is one of the most important things we can do for our long-term health. If people understand how important their muscles are, and make small changes to keep them healthy, that could have a huge impact on disease across the population.”

Small Steps to Strengthen Your Glutes

Improving glute muscle health doesn’t require intense gym sessions. Simple actions such as taking the stairs instead of the lift, adding squats or lunges to your routine, or breaking up long periods of sitting can help tone and strengthen the gluteus maximus.

Kidney disease is rising at an alarming pace worldwide, and it’s now among the top causes of death. A Lancet study highlights that the number of people living with chronic kidney disease jumped from 78 million in 1990 to nearly 788 million in 2023. That’s a massive tenfold spike, and a reminder that our kidneys need more attention than we realize.

The tricky part? Kidney problems often progress silently. Many people don’t realize anything is wrong until the kidneys are already significantly damaged. That’s why experts strongly emphasize early screening. According to nephrologists like Dr Arjun Sabharwal, a few simple tests — often quick and inexpensive — can help catch kidney issues early and improve treatment outcomes.

Below are the four key tests everyone should know about, especially if you have diabetes, high blood pressure, a family history of kidney disease, or you’re simply trying to stay proactive about your health.

Creatinine Blood Test & eGFR: Your First Kidney Health Check

eGFR uses creatinine values along with age and other factors to estimate how well your kidneys are functioning overall. Doctors often say, “Creatinine is just a number — eGFR tells you how much your kidneys are working.”

An eGFR below normal may be an early signal that your kidneys aren’t filtering efficiently, even if you feel fine.

Cystatin C: A More Accurate Indicator for Some People

Cystatin C is a protein produced naturally by all cells. When kidneys are healthy, its levels stay stable; when the kidneys struggle, the levels rise.

Experts highlight that Cystatin C can be more reliable than creatinine for people with very high muscle mass, those who work out intensely, or individuals taking supplements that may affect creatinine readings. If creatinine results seem unclear or inconsistent, this test adds clarity.

Urine Dipstick Test: Quick and Tells You a Lot

Before kidney function takes a major hit, the body often shows early warnings — one of which is protein leakage in urine. A urine dipstick test is one of the fastest ways to detect this.

A chemically treated strip is dipped into your urine sample, and if proteins like albumin are present, the strip changes color. It’s simple, non-invasive, and helpful for spotting early kidney damage.

Urine Protein-to-Creatinine Ratio (UPCR): How Much Protein Is Leaking

If a dipstick shows abnormalities, the next step is often a UPCR test. This test measures exactly how much protein is leaking into the urine relative to creatinine. Higher levels may signal worsening kidney function or underlying disease. Doctors use UPCR to assess the severity of kidney damage and monitor progress over time.

When to See a Nephrologist

If any test shows rising creatinine, an abnormal eGFR, protein in urine, or blood detected on a dipstick, it’s crucial to book an appointment. Lifestyle tweaks, home remedies, or detox drinks cannot reverse kidney damage. Expert evaluation is essential.

In 2025, thanks to climate change, rapid urbanization, and frequent travels, new viruses, their strains, and infections have spread frequently. Infections have affect millions and some diseases have come back with their new strains, which have been more contagious, whereas other diseases are finding new ways to emerge.

As we look back at the year, which is about to end in just another month, let us look back at the top 5 infectious diseases of 2025.

Respiratory Infections

In 2025, respiratory infections were the most widespread, with new COVID-19 variants emerging every now and then. Along with this common flu too has emerged. This has weakened immunity and made elderly and infants, and people with comorbidities more vulnerable to the diseases.

The new COVID variants in India are linked with the JN.1 variant and its sub-variants like LF.7 and NB.1.8. The COVID variants in the UK which were active were XFG, NB.1.8.1, or known as the Stratus and Nimbus variants. Other variants were XFG.3, XFG.5, and XFG.3.4.1.

Tuberculosis (TB)

Tuberculosis still continues to be a major infectious disease in 2025, especially in countries like India. As per the World Health Organization (WHO), tuberculosis caused 1.25 billion deaths in 2023. It becomes the world's leading infectious disease after COVID-19.

Each day, close to 3,425 people lose their lives to TB, and close to 30,000 people fall ill with this preventable and curable disease. About 10.8 million people got TB in 2023, which include 6 million, 3.6 million women, and 1.3 million children.

Dengue and other mosquito-borne infections

Mosquito-borne diseases like dengue, chikungunya, malaria, and Zika continued to rise in 2025. The reason being changing weather patterns. Dr Sanjeev Bagai, Chairman of Nephron Clinic, and Senior Consultant Pediatrician and Nephrologist points out that earlier the mosquito-borne diseases were seasonal, however, due to rapid urbanization and climate changes, these diseases have stayed all round the year.

Hepatitis Infections

Hepatitis B and Hepatitis C are among the most common Hepatitis infections in 2025. However, there have been outbreaks of Hepatitis A and E in unsafe water and food. Chronic hepatitis can also damage liver and also lead to cancer. It is a concern because it spreads through contaminated food, unsafe water, blood, and sexual contact. While many people may not show symptoms until serious liver damage occurs.

Symptoms also include jaundice, dark urine, fatigue, nausea, and abdominal pain.

Gastrointestinal Infections

Food- and water-borne infections are still common across the world. Illnesses like salmonella, cholera, rotavirus, and norovirus often spread in areas where hygiene, sanitation, and food safety are poorly maintained.

Why are these infections risky?

They can spread extremely fast, especially among children and older adults. Severe diarrhea and vomiting can lead to dangerous dehydration if not treated in time.

What symptoms should you look out for?

Persistent diarrhea, vomiting, stomach cramps, fever, and signs of dehydration. The best prevention is simple: drink clean water, wash hands regularly, and eat properly cooked food.