The COVID-19 pandemic may be over, but our immune systems are still feeling the impact. After years of battling constant viral threats, from COVID-19 to seasonal flu and other infections, our body’s defense system is exhausted. Many people continue to experience lingering inflammation, frequent illnesses, and slower recovery times. This extended state of immune stress has compromised us further to chronic illness, including autoimmune diseases and even neurodegenerative diseases such as Parkinson's. So why is our immune system still in trouble? And how do we give it its power back? Understanding immune exhaustion is the beginning of rebuilding our body's natural immunity.

A weakened immune system makes people more susceptible to disease, mental illnesses, and even sleep disorders. Now, new research indicates that immune system depletion may play an important role in the onset of Parkinson's disease, a degenerative neurologic disorder that compromises movement and cognition.

Role of Inflammation in Parkinson's Disease

Dysfunctional immune response is a leading cause of long-standing inflammation within the body, that has been found to contribute towards a multitude of conditions, including cardiovascular conditions, diabetes, depression, and neurodegenerative diseases such as Alzheimer's.

As people age, their immune system naturally becomes less effective. This deterioration, referred to as immune exhaustion, may be a key contributor to the onset and progression of Parkinson’s disease. Rebecca Wallings, a Parkinson’s Foundation Launch Award grant recipient and senior postdoctoral fellow at the University of Florida, believes that an accumulation of exhausted immune cells could be driving neurodegeneration in Parkinson’s patients.

How a Tired Immune System Might Affect Parkinson's?

Parkinson's disease is most commonly linked with the degeneration and loss of dopaminergic neurons—motor nerve cells that produce dopamine, an essential neurotransmitter for movement. While researchers have long suspected inflammation is involved in this neurodegeneration, the mechanisms are not yet well understood.

Wallings' study is on immune cell exhaustion, a process by which aging immune cells fail to control immune responses effectively. Her research indicates that instead of dampening inflammation in Parkinson's patients, attempts should be made to rejuvenate the immune system to regain its functionality.

Energy Deficiency in Immune Cells

One of the major findings of Wallings' work is the function of mitochondrial impairment in immune cell exhaustion. Mitochondria are commonly called the powerhouses of cells, as they are vital for generating energy. As mitochondria age and become inefficient, immune cells fail to function well, potentially accelerating neurodegeneration in Parkinson's disease.

Wallings has found that mutations in the LRRK2 gene, a recognized genetic risk factor for Parkinson's disease, are linked with defective mitochondrial function and immune cell exhaustion. Her current work includes testing various therapeutic approaches to restore mitochondrial function in immune cells with the potential to enhance the immune system and potentially prevent or treat Parkinson's disease.

Will Rejuvenating the Immune System Help in Treatment?

For decades, the standard practice in treating Parkinson's has been to suppress brain inflammation. Yet Wallings' work indicates that instead of slowing down immune responses, restoring the immune system could be a more successful strategy. By addressing mitochondrial impairment and immune resilience, researchers can potentially reverse or slow down Parkinson's disease.

Wallings is now looking into how to rejuvenate immune cells by fixing mitochondria. She studies immune cells from patients with Parkinson's as well as from healthy subjects and performs experiments on animal models to determine if rejuvenation of the immune system could result in improved disease outcomes.

Lifestyle Factors That May Affect Parkinson's Risk

While there is no cure for Parkinson's disease, some lifestyle adjustments may decrease the chances of developing the illness. Since neurodegenerative diseases are associated with chronic inflammation and immune dysfunction, developing habits that enhance immune function might prove helpful.

Diet: There is evidence to suggest that eating in accordance with the Mediterranean or MIND diets, both high in antioxidants, healthy fats, and anti-inflammatory foods, can encourage brain wellness and reduce Parkinson's risk.

Avoiding Dangerous Substances: Restricting alcohol and nicotine use can maintain a robust immune system and suppress inflammation.

Reducing Stress: Chronic stress weakens immune function, so methods such as meditation, exercise, and sufficient sleep can lead to improved overall well-being.

In today’s digital age, screens have become almost inseparable from daily life—even for very young children. While technology offers convenience and learning opportunities, increasing clinical observations have raised concerns about a phenomenon often referred to as “virtual autism." In an interview with Health and Me, Dr Aarti Javeri Manek, Paediatric Neurologist at Sir HN Reliance Foundation Hospital, explained what virtual autism is and the impact of screen time on children's brain health.

What is “virtual autism”?

Virtual autism is not a formally recognised medical diagnosis but rather a descriptive term used for children—typically toddlers—who exhibit autism-like features in the context of excessive screen exposure, particularly during critical periods of brain development. These children may show reduced eye contact, delayed speech, poor social interaction, and limited responsiveness to their environment.

Also Read: Cancer Is The 10th Leading Cause Of Death In Indian Children: Study

However, it is crucial to distinguish this entity from clinical Autism Spectrum Disorder (ASD). ASD is a neurodevelopmental condition, often with a strong underlying genetic and biological basis, present in addition to exogenous influences. External stimulus exposure may not even be apparent. In contrast, children with virtual autism often demonstrate significant improvement when screen time is reduced and replaced with real-world, interactive experiences. This reversibility is a key differentiating factor.

Read more: Is My Child Shy Or Autistic? Psychiatrist Shares Tips To Help Parents Spot Early Signs

What early signs should parents watch for?

From a neurological perspective, early childhood is a period of rapid synaptic growth, heavily influenced by sensory and social input. When screens replace human interaction, this can impact language acquisition, attention, and social interaction.

Some red flags that may suggest screen-related developmental delays include:

1. Limited or absent eye contact
2. Reduced response to name
3. Delayed speech or loss of previously acquired words
4. Preference for screens over people
5. Decreased or limited gestures (not pointing, showing, or sharing interest)
6. Repetitive behaviours such as watching the same videos excessively or viewing the same rhyme persistently
7. Irritability or meltdowns when screens are removed

While these signs overlap with autism, the context is important. A history of prolonged, unsupervised screen exposure, often exceeding 3–4 hours per day in toddlers, should prompt consideration of environmental impact.

Read more: Can Cell Therapy Be The Future Of Autism Treatment?

Are toddlers at greater risk compared to older children?

Yes, significantly so. The first three years of life are critical for brain development, particularly for language, social bonding, and emotional regulation. During this period, the brain relies heavily on serve-and-return interactions—a child babbles, a caregiver responds; a child points, and a parent names the object. These exchanges build neural circuits essential for communication and cognition.

Screens, even educational ones, are inherently passive. They do not adapt in real time to a child’s cues in the same way a human does. Excessive exposure during this sensitive window can therefore displace meaningful interactions, leading to significant developmental delays.

Older children, while not immune, are generally more resilient, as they have already established foundational social and language skills. However, excessive screen time in this group may still contribute to attention difficulties, behavioural issues, and reduced social engagement.

What can parents do?

The encouraging aspect of virtual autism is its potential reversibility if it is identified early. Reducing screen exposure, especially in children under 2 years, and reintroducing interactive play, storytelling, and face-to-face communication may lead to noticeable improvements. Ultimately, screens are tools and not substitutes for relationships. In early childhood, it is these relationships that shape the developing brain most profoundly.

For some people, getting inked is more than a passion—it is a form of self-expression. And tattoos are nothing short of an addiction; it is not easy to stop at one. Despite being a painful procedure that requires a great deal of caution—using fresh needles and safe ink, for instance—several incidents come to light where getting a tattoo goes wrong in irreversible ways. In a recent case, a man developed a weeping, black ulcer of dead flesh on his neck months after getting a tattoo. In this case, doctors blamed this reaction on the colour of the tattoo ink—it may have triggered inflammation that caused the skin to blacken and die.

A reaction from the tattoo ink

A 20-year-old man had a red cross tattoo on the base of his neck. After three months, it faded away spontaneously and was replaced by scars and bumps on either side of the neck, accompanied by a necrotic ulcer. In this case, when the tissue blackens and dies, it results in a painful wound. The unnamed man was hospitalised five months after getting his first tattoo. Doctors examining the patient found that the lymph nodes, which help fight infections, were swollen and hard. Doctors also examined a large crusted ulcer, which had spread across the base of the neck and had seeped into deeper layers of skin.

Read more: Tattoos May Increase Cancer Risk, Study Suggests

Doctors also performed an MRI and found large lumps around the ulcer that measured up to 5 cm. There were two blood clots in the jugular vein as well. Two biopsies were taken of the necrotic ulcer, but they did not reveal what may have triggered the necrosis. The team was then concerned about the scan results and how fast the patient's condition was progressing. He was then rushed into surgery, where doctors removed the ulcer along with masses on the neck. His neck was then reconstructed using fat from the thighs. The patient was then diagnosed with necrotising granulomatous lymphadenitis.

What is necrotising granulomatous lymphadenitis?

Necrotising granulomatous lymphadenitis is an inflammatory condition wherein the lymph node tissues die and form clumps of immune cells known as granulomas. This can develop in response to an injury, and in this case, doctors said that the tattoo was to blame.

Doctors said that heavy metals like cadmium and mercury in organic tattoo ink can result in an immune response. From surgery to recovery, the patient's case is published in the journal JAMA Otolaryngology. Experts say that this is only the second known case of necrosis after a tattoo.

What are the riskiest spots for a tattoo?

Getting a tattoo can be painful, but for some people, the pain is worth it. However, according to experts, there are some spots that are not ideal for getting a tattoo. These are:

1. Eyes—can lead to partial or complete blindness
2. Genitals – heightened risk of contracting sexually transmitted diseases and infections
3. Spine – a tattoo on the spine is extremely painful, and if it goes wrong, there could be irreversible repercussions

As winter transitions into warmer summer months, many people notice a sudden worsening of dandruff. During colder months, dandruff often appears as dry, fine flakes due to scalp dryness. However, as temperatures rise and humidity increases, dandruff can become oily and sticky because of increased sweating and sebum production. This seasonal shift highlights that dandruff is not limited to a particular time of year; rather, changes in climate can disrupt scalp balance and trigger flare-ups. Dr. Anupriya Goel, MBBS, MD, DPD (UK) – Dermatology, answered this for us.

Why does dandruff recur?

Many people struggle to understand why dandruff keeps recurring. It is often treated as a temporary cosmetic concern, but in reality, dandruff is a chronic scalp condition that requires consistent care and appropriate treatment. The primary cause of dandruff is a yeast called Malassezia globosa, which naturally resides on the scalp. This microorganism feeds on sebum (the natural oils produced by the scalp). As it breaks down these oils, it releases by-products that can irritate the scalp, leading to inflammation, itching, and visible flaking.

Seasonal factors further aggravate this process. In winter, cold air, low humidity, indoor heating, and frequent hot showers can strip the scalp of its natural moisture and weaken the skin barrier, resulting in dryness and flaking. In contrast, summer brings increased sweat and oil production. The combination of humidity, sweat, and sebum creates an ideal environment for Malassezia to multiply, which can worsen dandruff symptoms.

Read here: Simple Secrets To Establishing The Right Winter Hair Care Routine

What are the external factors responsible for dandruff?

Environmental factors such as pollution can also settle on the scalp and contribute to irritation. In addition, daily habits like wearing helmets for long hours, tying up damp hair, or not cleansing the scalp regularly can further disrupt scalp health. The transition period between seasons is often the most challenging, as the scalp has limited time to adapt to changing environmental conditions.

Because dandruff is often mistaken for a temporary issue, many people rely on occasional treatments or home remedies. However, effective management typically requires regular scalp-focused care using clinically proven active ingredients.

Treating dandruff

One such ingredient commonly used in anti-dandruff formulations is Piroctone Olamine, an antifungal agent that helps control the growth of Malassezia on the scalp. By reducing fungal proliferation, it helps address the underlying cause of dandruff and can assist in decreasing flaking, itching, and scalp irritation. It also helps cleanse the scalp by removing excess oil and buildup while being relatively gentle on the hair and scalp.

Read more: 7 Ayurvedic Hair Health Tips You Should Try For Healthy Locks

For optimal results, individuals experiencing recurrent dandruff may benefit from incorporating an anti-dandruff shampoo containing Piroctone Olamine into their regular hair care routine. Consistent use is important for maintaining scalp balance. During periods of increased sweating, such as in hot and humid weather, washing frequency may be increased as needed. Maintaining hygiene practices such as regularly cleaning helmets, pillowcases, and hair accessories can also help minimise recurrence.

In addition to controlling dandruff, well-formulated shampoos containing Piroctone Olamine are often combined with conditioning and moisturising ingredients that help maintain hair softness and scalp comfort while supporting long-term scalp balance.