The COVID-19 pandemic may be over, but our immune systems are still feeling the impact. After years of battling constant viral threats, from COVID-19 to seasonal flu and other infections, our body’s defense system is exhausted. Many people continue to experience lingering inflammation, frequent illnesses, and slower recovery times. This extended state of immune stress has compromised us further to chronic illness, including autoimmune diseases and even neurodegenerative diseases such as Parkinson's. So why is our immune system still in trouble? And how do we give it its power back? Understanding immune exhaustion is the beginning of rebuilding our body's natural immunity.

A weakened immune system makes people more susceptible to disease, mental illnesses, and even sleep disorders. Now, new research indicates that immune system depletion may play an important role in the onset of Parkinson's disease, a degenerative neurologic disorder that compromises movement and cognition.

Role of Inflammation in Parkinson's Disease

Dysfunctional immune response is a leading cause of long-standing inflammation within the body, that has been found to contribute towards a multitude of conditions, including cardiovascular conditions, diabetes, depression, and neurodegenerative diseases such as Alzheimer's.

As people age, their immune system naturally becomes less effective. This deterioration, referred to as immune exhaustion, may be a key contributor to the onset and progression of Parkinson’s disease. Rebecca Wallings, a Parkinson’s Foundation Launch Award grant recipient and senior postdoctoral fellow at the University of Florida, believes that an accumulation of exhausted immune cells could be driving neurodegeneration in Parkinson’s patients.

How a Tired Immune System Might Affect Parkinson's?

Parkinson's disease is most commonly linked with the degeneration and loss of dopaminergic neurons—motor nerve cells that produce dopamine, an essential neurotransmitter for movement. While researchers have long suspected inflammation is involved in this neurodegeneration, the mechanisms are not yet well understood.

Wallings' study is on immune cell exhaustion, a process by which aging immune cells fail to control immune responses effectively. Her research indicates that instead of dampening inflammation in Parkinson's patients, attempts should be made to rejuvenate the immune system to regain its functionality.

Energy Deficiency in Immune Cells

One of the major findings of Wallings' work is the function of mitochondrial impairment in immune cell exhaustion. Mitochondria are commonly called the powerhouses of cells, as they are vital for generating energy. As mitochondria age and become inefficient, immune cells fail to function well, potentially accelerating neurodegeneration in Parkinson's disease.

Wallings has found that mutations in the LRRK2 gene, a recognized genetic risk factor for Parkinson's disease, are linked with defective mitochondrial function and immune cell exhaustion. Her current work includes testing various therapeutic approaches to restore mitochondrial function in immune cells with the potential to enhance the immune system and potentially prevent or treat Parkinson's disease.

Will Rejuvenating the Immune System Help in Treatment?

For decades, the standard practice in treating Parkinson's has been to suppress brain inflammation. Yet Wallings' work indicates that instead of slowing down immune responses, restoring the immune system could be a more successful strategy. By addressing mitochondrial impairment and immune resilience, researchers can potentially reverse or slow down Parkinson's disease.

Wallings is now looking into how to rejuvenate immune cells by fixing mitochondria. She studies immune cells from patients with Parkinson's as well as from healthy subjects and performs experiments on animal models to determine if rejuvenation of the immune system could result in improved disease outcomes.

Lifestyle Factors That May Affect Parkinson's Risk

While there is no cure for Parkinson's disease, some lifestyle adjustments may decrease the chances of developing the illness. Since neurodegenerative diseases are associated with chronic inflammation and immune dysfunction, developing habits that enhance immune function might prove helpful.

Diet: There is evidence to suggest that eating in accordance with the Mediterranean or MIND diets, both high in antioxidants, healthy fats, and anti-inflammatory foods, can encourage brain wellness and reduce Parkinson's risk.

Avoiding Dangerous Substances: Restricting alcohol and nicotine use can maintain a robust immune system and suppress inflammation.

Reducing Stress: Chronic stress weakens immune function, so methods such as meditation, exercise, and sufficient sleep can lead to improved overall well-being.

As temperatures fall, a growing number of people are seeking medical advice for sudden, painful rashes and nerve-related discomfort. Superdrug Online Doctor has reported a 50% rise in patients requesting consultations for shingles over recent weeks. Shingles develops when the chickenpox virus, which stays dormant in the body after childhood infection, becomes active again later in life.

What Is Shingles?

Shingles, also known as herpes zoster, is a viral illness that causes a painful, blistering rash, usually appearing on one side of the body. It occurs when the varicella-zoster virus, which causes chickenpox, becomes active again after lying dormant in the nerves for many years. This reactivation is more likely when the immune system is weakened.

Symptoms often begin with burning, tingling, or itching in a specific area, followed by clusters of fluid-filled blisters that eventually dry out and form scabs. Starting antiviral treatment early can help reduce the severity and length of the infection. A shingles vaccine is also available and is recommended, particularly for people over the age of 50, to lower the risk of developing shingles and to prevent complications such as long-lasting nerve pain, known as postherpetic neuralgia.

Who Is Most At Risk Of Shingles?

The condition is more likely to affect older adults and people with weakened immune systems. Dr Babak Ashrafi, Superdrug’s Online Doctor, explained that many patients are caught off guard by how quickly symptoms appear. “Shingles often begins unexpectedly,” he said. “People may wake up with a burning or tingling sensation, followed by a rash that rapidly becomes more painful. We typically see higher numbers during colder months, when immune defences are under greater pressure.”

Winter-related factors such as stress, poor sleep, and seasonal infections can all take a toll on the immune system. When immunity dips, the virus responsible for shingles has a greater chance of reactivating, increasing the likelihood of flare-ups during colder periods.

Shingles Early Warning Signs To Watch For

According to the NHS, early symptoms of shingles often include a tingling, itching, or painful sensation on one side of the body. Some people may also experience headaches or feel generally unwell before a rash appears. The rash usually develops a few days later and is most commonly seen on the chest or abdomen, although it can occur anywhere on the body.

Superdrug Online Doctor has outlined five situations where people should seek prompt medical advice rather than rely on self-care. These include cases where:

• the rash appears on or near the eye
• pain is severe or spreading
• the person has a weakened immune system
• the individual is pregnant
• symptoms are worsening quickly

Shingles Treatment

Superdrug Online Doctor provides an online assessment and photo-diagnosis service, allowing clinicians to review symptoms remotely. Where appropriate, patients can be prescribed antiviral medication without needing to wait for a GP appointment.

Dr Ashrafi stressed the importance of acting quickly, adding: “The most important advice is not to wait and see. Starting treatment early can make a significant difference to recovery and long-term outcomes.”

Doctors are reporting a change in the way the flu is presenting as a new strain spreads across the UK. Hospital admissions linked to the flu rose sharply at the beginning of the year, with an average of 2,924 people a day admitted by January 4. Four hospital trusts have declared critical incidents, citing ongoing and intense pressure on services. These include three trusts in Surrey and one in Kent.

Surrey Heartlands Trust said winter pressures had been made worse by a rise in flu and norovirus cases. NHS national medical director Professor Meghana Pandit said the situation remains difficult, with hospitals seeing another increase in patients admitted with flu and other respiratory infections last week.

She said it is still vital for people to seek medical help when needed and reminded the public that there are many chances to get vaccinated against flu. Health Secretary Wes Streeting also stressed that flu can be dangerous, especially for older adults, young children, and those with existing health problems. He urged everyone who qualifies to get their flu vaccine as soon as possible, calling it the best form of protection.

Doctors Report Unusual Symptoms As New Flu Strain Spreads Across The UK

Doctors say this latest flu strain appears to be causing different symptoms. The virus, known as subclade K, is a variant of the A H3N2 type of influenza.

Dr Mark Loafman told NBC Chicago that many patients are experiencing much higher fevers than usual. He said the fever can last five to seven days, which is longer than people typically expect and is a cause for concern.

In some cases, doctors say the fever does not respond well to common medicines such as paracetamol or ibuprofen. Lung specialist Dr Juanita Mora said this strain is linked to very high temperatures, a severe and persistent cough with heavy phlegm, vomiting, diarrhoea, and widespread joint and muscle pain.

Doctors have also noticed a rise in stomach-related symptoms, including nausea and vomiting, often referred to as gastrointestinal or GI issues. Dr Loafman said that, based on what doctors are seeing, adults infected with the subclade K strain seem to be showing more signs of GI illness than usual.

According to the NHS, flu symptoms usually appear suddenly and tend to be much more severe than those of a common cold. While most people start to recover within about a week, the illness can feel particularly harsh while it lasts.

Key Symptoms of Flu

The main symptoms usually begin abruptly and include:

• A sudden high temperature of 38C or higher
• Body aches affecting muscles and joints
• Extreme tiredness or exhaustion
• A dry cough
• A sore throat
• Headaches
• Problems sleeping
• Reduced appetite
• Nausea, vomiting, or diarrhoea, which are more common in children

How To Treat Flu at Home

Most people can deal with flu symptoms at home without needing to see a doctor. The NHS advises the following self-care measures:

• Rest and Sleep: Allow your body time and energy to fight off the infection.
• Stay Warm: Use extra layers or blankets to maintain body warmth.
• Hydration: Drink plenty of fluids to prevent dehydration. Your urine should be pale yellow or clear.
• Pain Relief: Paracetamol or ibuprofen can help reduce fever and ease aches. Avoid taking combination flu medicines alongside paracetamol tablets, as this can lead to taking too much.
• Sore Throat Relief: Gargle with salt water if you are an adult, or have hot drinks such as lemon and honey to ease discomfort.

People across the UK are being urged to follow basic safety steps as concerns grow over so-called “evolving” bacteria. A few decades ago, antibiotics were routinely prescribed for a wide range of illnesses and minor infections.

Today, many GPs are far more cautious about giving them out, largely because of the steady rise in bacteria that no longer respond to treatment. Figures from the UK Health Security Agency show that close to 400 antibiotic-resistant infections are being recorded every week in England.

What Are Antibiotic-Resistant Infections?

According to the World Health Organisation (WHO), antibiotic-resistant infections develop when bacteria change over time and stop responding to the medicines meant to kill them. As a result, infections that were once easy to treat become much harder, and in some cases impossible, to cure. This can lead to serious illness, longer hospital stays, and a higher risk of death.

While antibiotic resistance can occur naturally, the WHO warns that misuse and overuse of antibiotics in both humans and animals greatly speeds up the process. This allows resistant bacteria, often referred to as “superbugs,” to survive, multiply, and spread more easily.

Why Is Antibiotic Resistance Dangerous?

The biggest risk linked to these “superbugs” is that they are much harder to treat because standard antibiotics no longer work against them. Infections caused by resistant bacteria can lead to serious complications, including pneumonia and bloodstream infections, which can be life-threatening if not controlled quickly.

In a post shared on X, the UKHSA said: “Bacteria are evolving against antibiotics, with nearly 400 new resistant infections appearing each week in England.” NHS guidance has also warned that several bacteria have already developed resistance as a result of antibiotic overuse. These include MRSA, Clostridium difficile, and the bacteria linked to multidrug-resistant tuberculosis.

A major concern is that this growing trend could eventually lead to new strains of bacteria that cannot be treated with any existing antibiotics.

How To Reduce The Risk Of Antibiotic-Resistant Infections?

According to UKHSA advice, people can play a role in slowing the spread of resistant bacteria by following a few simple precautions in daily life. These include:

• Returning unused antibiotics to a pharmacy so they can be disposed of safely and do not contribute to resistance in the environment
• Practising safe sex, particularly to reduce the spread of infections such as gonorrhoea, which is becoming harder to treat
• Staying up to date with vaccinations, which can help prevent infections in the first place
• Talking to a healthcare professional before taking antibiotics, as they are not always necessary
• Washing hands thoroughly and staying at home when feeling unwell to avoid spreading infection