The COVID-19 pandemic may be over, but our immune systems are still feeling the impact. After years of battling constant viral threats, from COVID-19 to seasonal flu and other infections, our body’s defense system is exhausted. Many people continue to experience lingering inflammation, frequent illnesses, and slower recovery times. This extended state of immune stress has compromised us further to chronic illness, including autoimmune diseases and even neurodegenerative diseases such as Parkinson's. So why is our immune system still in trouble? And how do we give it its power back? Understanding immune exhaustion is the beginning of rebuilding our body's natural immunity.

A weakened immune system makes people more susceptible to disease, mental illnesses, and even sleep disorders. Now, new research indicates that immune system depletion may play an important role in the onset of Parkinson's disease, a degenerative neurologic disorder that compromises movement and cognition.

Role of Inflammation in Parkinson's Disease

Dysfunctional immune response is a leading cause of long-standing inflammation within the body, that has been found to contribute towards a multitude of conditions, including cardiovascular conditions, diabetes, depression, and neurodegenerative diseases such as Alzheimer's.

As people age, their immune system naturally becomes less effective. This deterioration, referred to as immune exhaustion, may be a key contributor to the onset and progression of Parkinson’s disease. Rebecca Wallings, a Parkinson’s Foundation Launch Award grant recipient and senior postdoctoral fellow at the University of Florida, believes that an accumulation of exhausted immune cells could be driving neurodegeneration in Parkinson’s patients.

How a Tired Immune System Might Affect Parkinson's?

Parkinson's disease is most commonly linked with the degeneration and loss of dopaminergic neurons—motor nerve cells that produce dopamine, an essential neurotransmitter for movement. While researchers have long suspected inflammation is involved in this neurodegeneration, the mechanisms are not yet well understood.

Wallings' study is on immune cell exhaustion, a process by which aging immune cells fail to control immune responses effectively. Her research indicates that instead of dampening inflammation in Parkinson's patients, attempts should be made to rejuvenate the immune system to regain its functionality.

Energy Deficiency in Immune Cells

One of the major findings of Wallings' work is the function of mitochondrial impairment in immune cell exhaustion. Mitochondria are commonly called the powerhouses of cells, as they are vital for generating energy. As mitochondria age and become inefficient, immune cells fail to function well, potentially accelerating neurodegeneration in Parkinson's disease.

Wallings has found that mutations in the LRRK2 gene, a recognized genetic risk factor for Parkinson's disease, are linked with defective mitochondrial function and immune cell exhaustion. Her current work includes testing various therapeutic approaches to restore mitochondrial function in immune cells with the potential to enhance the immune system and potentially prevent or treat Parkinson's disease.

Will Rejuvenating the Immune System Help in Treatment?

For decades, the standard practice in treating Parkinson's has been to suppress brain inflammation. Yet Wallings' work indicates that instead of slowing down immune responses, restoring the immune system could be a more successful strategy. By addressing mitochondrial impairment and immune resilience, researchers can potentially reverse or slow down Parkinson's disease.

Wallings is now looking into how to rejuvenate immune cells by fixing mitochondria. She studies immune cells from patients with Parkinson's as well as from healthy subjects and performs experiments on animal models to determine if rejuvenation of the immune system could result in improved disease outcomes.

Lifestyle Factors That May Affect Parkinson's Risk

While there is no cure for Parkinson's disease, some lifestyle adjustments may decrease the chances of developing the illness. Since neurodegenerative diseases are associated with chronic inflammation and immune dysfunction, developing habits that enhance immune function might prove helpful.

Diet: There is evidence to suggest that eating in accordance with the Mediterranean or MIND diets, both high in antioxidants, healthy fats, and anti-inflammatory foods, can encourage brain wellness and reduce Parkinson's risk.

Avoiding Dangerous Substances: Restricting alcohol and nicotine use can maintain a robust immune system and suppress inflammation.

Reducing Stress: Chronic stress weakens immune function, so methods such as meditation, exercise, and sufficient sleep can lead to improved overall well-being.

TikTok has a new sleep obsession every few months. Mouth taping, "cognitive shuffling," and now this: pouring salt onto a tray and stomping on it barefoot before bed. It's called "salt stomping," and doctors have doubts.

What Is Salt Stomping?

The trend was popularised by TikTok creator Tammy Weatherhead, who films herself pouring Epsom salt onto a baking sheet and shuffling her feet on it, according to the New York Post. "If you are not standing on salt before bed, you are missing out," she says in her videos. Other creators pour the salt onto baking sheets, towels or straight onto the shower floor, according to the New York Post.

The practice is framed as a type of "grounding," or direct contact with the earth, which some people normally do by walking barefoot on grass or sand, the New York Post notes. Weatherhead claims the salt version also exfoliates feet, reduces inflammation, and shifts the body into "rest mode" by lowering cortisol and raising serotonin.

Also Read: Heart Valve Clips Explained: How a Tiny Clip Can Help Repair a Leaking Valve

Does It Actually Work?

Doctors say no. Saema Tahir, a board-certified sleep physician, told the New York Post, "There's no evidence that standing on salt calms anything." IOL, a South African outlet, reported the same conclusion. There is currently no scientific evidence that standing directly on salt improves sleep.

There is some research on grounding in general, separate from salt. A small 2004 study published in the Journal of Alternative and Complementary Medicine found that people who slept in contact with a grounding mat had lower night-time cortisol levels. But the study didn't test salt, involved a small group of people, and hasn't been repeated at a larger scale since.

What might actually help is the ritual itself, not the salt. Jacqueline Geer, a sleep medicine specialist at Yale School of Medicine, told Vogue, as reported by Yahoo, that the benefit "lies in the fact that this trend requires a certain level of focus and disconnect" from a busy day. A psychologist identified as Dr. Bostock told the Huffington Post UK there's likely a placebo effect too: "If you believe something helps you sleep, the odds are you will fall asleep faster and stay asleep longer."

The Real Risk: Your Skin

Standing barefoot on salt can cause harm. Chris Winter, a neurologist and sleep specialist, told Vogue, as reported by Yahoo, that salt stomping can cause skin irritation, worsen cracks on the feet, and create small cuts that let bacteria into the body.

What To Do Instead

Sleep experts point to simpler, low-risk habits: calming, repetitive routines before bed that signal to the nervous system it's time to rest, per IOL. Geer's advice, per Yahoo, is to build in a period of focus and disconnection from screens and stress, rather than a specific trick. If anxiety is what's keeping you up at night, that's worth raising with a doctor directly, rather than testing viral hacks with no real evidence behind them.

Heart clips—also referred to as heart valve clips—are part of a minimally invasive medical procedure known as Transcatheter Edge-to-Edge Repair (TEER). Designed to repair leaking heart valves without open-heart surgery, this advanced treatment restores proper blood flow, relieves debilitating symptoms, and helps patients return to their daily lives.

Understanding Valve Leakage and Symptoms

The heart's valves rely on thin flaps of tissue called leaflets to regulate blood flow.

• The mitral valve (located on the left side of the heart) typically has two leaflets.

• The tricuspid valve (located on the right side of the heart) usually consists of three leaflets.

When a valve is leaking, the leaflets fail to close completely, leaving a gap. Blood leaks backward through this opening toward the lungs, increasing lung pressure and directly causing chronic breathlessness and fatigue.

Also read: 100% Blockage At 18, 25% Patients Under 40: On World Heart Day, Cardiologists Reveal An Alarming Heart Attack Pattern

How the Clip Repair Procedure Works

During a Transcatheter Edge-to-Edge Repair, cardiologists repair the valve using a tiny clip delivered through the vascular system:

1. Catheter Access: Guided by continuous echo imaging, doctors insert a catheter into a blood vessel in the groin and navigate it directly to the heart.
2. Targeting the Valve: The catheter goes to the left side of the heart for a mitral valve repair or to the right side for a tricuspid valve repair.
3. Identifying the Leak: Imaging pinpoints the exact spot where the leaflets fail to seal.
4. Deploying the Clip: The doctor positions and deploys the clip across the leaking gap, grasping the two opposing leaflets and pulling them closer together.
5. Evaluating the Seal: Before releasing the clip completely, doctors perform an echocardiogram to confirm that the clip is strongly anchored, that the backward leak is fixed, and that the risk of clip detachment (embolization) is negligible.

Immediate Relief and Long-Term Healing

Once the clip brings the leaflets together, backward leakage stops immediately, allowing the entire volume of blood to pump forward as intended.

• 24-Hour Recovery: Pressure inside the lungs drops rapidly once the leak is sealed. Many patients notice a dramatic improvement in their breathing within 24 hours of the procedure.

• 3 to 6 Month Integration: Over a period of three to six months, surrounding heart tissue naturally grows over the clip (endothelialization), permanently integrating it into the heart structure.

Smooth Hospital Stay and Recovery

Because the procedure is catheter-based rather than open-chest, patient recovery is remarkably swift:

• In-Room Extubation: Patients are taken off the ventilator right on the procedure table.

• Minimal Closure Site: The groin entry point is closed cleanly using specialized sutures (such as ProGlide or a figure-of-eight suture).

• Quick Discharge: Patients typically spend just one day in the Intensive Care Unit (ICU) before moving to a standard room, after which they can return home and resume normal daily activities.

Frequent cannabis use may worsen epilepsy-related symptoms, new research. It discovered that raised that people with drug-resistant epilepsy who used cannabis often had more frequent convulsive seizures and sought advanced epilepsy care much sooner than non-users.

Published in Epilepsia, the study analysed health records of 64 adults with drug-resistant epilepsy. It found that frequent cannabis users reached an intensive epilepsy monitoring stage an average of five years after their first seizure, compared to 18 years reported among non-users.

The difference of 13 years is attention-worthy but it must be noted that the study shows an association, not proof that cannabis worsens epilepsy.

Seizures Doubled In Cannabis Users With Epilepsy

Researchers compared 22 people who used cannabis at least 20 days a month to 42 people who did not.

The frequent users reported to have a heavier burden of seizure, one of the symptoms of epilepsy. They had more than twice as many convulsive seizures per year than non-users.

About 91% of frequent cannabis users experienced convulsive seizures, compared to roughly half of the non-users.

Seizures involve stiffening and jerking of the body and loss of consciousness. They constitute medical emergency as they are associated with sudden death in epilepsy.

Also read: Does Cannabis Really Help You Sleep? Experts Say It Is Complicated

What Does Drug-Resistant Epilepsy Mean?

Epilepsy is considered drug-resistant when seizures continue despite appropriate treatment with two antiseizure medications.

People with drug-resistant epilepsy may need to visit specialised epilepsy centres, where doctors can monitor them and recommend changes in medication, surgery, or other treatment options. In this study, frequent cannabis users reached this stage much earlier.

They were also discharged from hospital after taking an average of 3.05 antiseizure medications, compared with 2.21 among non-users.

Also read: Why Can’t Millennials Sleep? The Crisis Keeping An Entire Generation Up At Night

Cannabis & Epilepsy

This was a retrospective study based on health records of a small sample size. There may be other differences between people who used cannabis often and those who did not that could affect the severity of the seizures.

However, researchers were able to establish the timing of cannabis use for 15 of the 22 users. All 15 had started using cannabis before their first seizure, making it less likely that they had simply begun using cannabis to cope with an already existing seizure disorder.

The researchers say larger studies can determine whether cannabis contributes to worsening seizures.

The association between cannabis and seizures is complicated as CBD (cannabidiol) is reported to have beneficial effect on severe epilepsy.

To understand the seeming contradiction, we must understand the distinction between cannabis and purified cannabidiol (CBD).

A purified form of CBD is an approved treatment for certain severe forms of epilepsy. CBD is different from THC, the psychoactive element responsible for the “high” associated with cannabis. Recreational cannabis products may contain high concentrations of THC.

According to the researchers, animal studies suggest CBD can suppress seizures, while THC may have the opposite effect.

Hence, evidence that a specific CBD-based medicine can help certain epilepsy syndromes cannot be used to conclude that recreational cannabis is an epilepsy treatment.

Researchers suggest that THC acts on receptors concentrated in brain regions involved in seizures, raising the possibility that cannabis could influence how brain circuits fire. But this is a hypothesis that needs further investigation.