The COVID-19 pandemic may be over, but our immune systems are still feeling the impact. After years of battling constant viral threats, from COVID-19 to seasonal flu and other infections, our body’s defense system is exhausted. Many people continue to experience lingering inflammation, frequent illnesses, and slower recovery times. This extended state of immune stress has compromised us further to chronic illness, including autoimmune diseases and even neurodegenerative diseases such as Parkinson's. So why is our immune system still in trouble? And how do we give it its power back? Understanding immune exhaustion is the beginning of rebuilding our body's natural immunity.

A weakened immune system makes people more susceptible to disease, mental illnesses, and even sleep disorders. Now, new research indicates that immune system depletion may play an important role in the onset of Parkinson's disease, a degenerative neurologic disorder that compromises movement and cognition.

Role of Inflammation in Parkinson's Disease

Dysfunctional immune response is a leading cause of long-standing inflammation within the body, that has been found to contribute towards a multitude of conditions, including cardiovascular conditions, diabetes, depression, and neurodegenerative diseases such as Alzheimer's.

As people age, their immune system naturally becomes less effective. This deterioration, referred to as immune exhaustion, may be a key contributor to the onset and progression of Parkinson’s disease. Rebecca Wallings, a Parkinson’s Foundation Launch Award grant recipient and senior postdoctoral fellow at the University of Florida, believes that an accumulation of exhausted immune cells could be driving neurodegeneration in Parkinson’s patients.

How a Tired Immune System Might Affect Parkinson's?

Parkinson's disease is most commonly linked with the degeneration and loss of dopaminergic neurons—motor nerve cells that produce dopamine, an essential neurotransmitter for movement. While researchers have long suspected inflammation is involved in this neurodegeneration, the mechanisms are not yet well understood.

Wallings' study is on immune cell exhaustion, a process by which aging immune cells fail to control immune responses effectively. Her research indicates that instead of dampening inflammation in Parkinson's patients, attempts should be made to rejuvenate the immune system to regain its functionality.

Energy Deficiency in Immune Cells

One of the major findings of Wallings' work is the function of mitochondrial impairment in immune cell exhaustion. Mitochondria are commonly called the powerhouses of cells, as they are vital for generating energy. As mitochondria age and become inefficient, immune cells fail to function well, potentially accelerating neurodegeneration in Parkinson's disease.

Wallings has found that mutations in the LRRK2 gene, a recognized genetic risk factor for Parkinson's disease, are linked with defective mitochondrial function and immune cell exhaustion. Her current work includes testing various therapeutic approaches to restore mitochondrial function in immune cells with the potential to enhance the immune system and potentially prevent or treat Parkinson's disease.

Will Rejuvenating the Immune System Help in Treatment?

For decades, the standard practice in treating Parkinson's has been to suppress brain inflammation. Yet Wallings' work indicates that instead of slowing down immune responses, restoring the immune system could be a more successful strategy. By addressing mitochondrial impairment and immune resilience, researchers can potentially reverse or slow down Parkinson's disease.

Wallings is now looking into how to rejuvenate immune cells by fixing mitochondria. She studies immune cells from patients with Parkinson's as well as from healthy subjects and performs experiments on animal models to determine if rejuvenation of the immune system could result in improved disease outcomes.

Lifestyle Factors That May Affect Parkinson's Risk

While there is no cure for Parkinson's disease, some lifestyle adjustments may decrease the chances of developing the illness. Since neurodegenerative diseases are associated with chronic inflammation and immune dysfunction, developing habits that enhance immune function might prove helpful.

Diet: There is evidence to suggest that eating in accordance with the Mediterranean or MIND diets, both high in antioxidants, healthy fats, and anti-inflammatory foods, can encourage brain wellness and reduce Parkinson's risk.

Avoiding Dangerous Substances: Restricting alcohol and nicotine use can maintain a robust immune system and suppress inflammation.

Reducing Stress: Chronic stress weakens immune function, so methods such as meditation, exercise, and sufficient sleep can lead to improved overall well-being.

Fever is one of the body's most common warning signals. In most cases, particularly among children, it is caused by a simple infection and resolves within a few days. However, when fever keeps returning repeatedly, follows a pattern, or occurs alongside other concerning symptoms, it may signal an underlying health condition that requires medical attention.

What Is A Recurring Fever?

Dr. Hemalata Arora, Director of Internal Medicine at Nanavati Max Super Speciality Hospital, Mumbai, told HealthandMe that a recurring fever refers to repeated episodes of elevated body temperature that are separated by days, weeks, or even months during which a person feels completely well.

While recurrent fevers can sometimes result from common viral infections, especially in children exposed to school environments, daycare settings, or seasonal illnesses, persistent or unexplained episodes warrant further investigation.

The expert stated that understanding the pattern of fever is often one of the most important clues in determining the cause.

What Can Cause Recurring Fever?

Dr. Diksha Goyal, Consultant in Internal Medicine at Marengo Asia Hospitals, Gurugram, told HealthandMe that a recurrent fever can occur when body temperature rises to 38°C or higher and reappears after improving or occurs intermittently over time.

Several medical conditions may cause recurring fever, including:

1. Chronic Infections such as tuberculosis (TB), urinary tract infections

2. Autoimmune Diseases

3. Immune System Disorders

4. Cancers, particularly blood-related cancers

5. Certain Viral Infections

Also read: Doctors Call Kratom The ‘Next Addiction Crisis’ As More US States Push Bans

Warning Signs That Should Not Be Ignored

While recurrent fever is not always dangerous, the experts emphasize that certain accompanying symptoms require prompt medical evaluation.

Dr. Arora notes that urgent attention is needed if recurring fever is associated with:

• Unexplained weight loss
• Night sweats
• Persistent fatigue or unusual tiredness
• Poor appetite
• Repeated vomiting
• Breathing difficulties
• Persistent abdominal pain
• Confusion or altered mental status

Dr. Goyal added that persistent cough, swollen lymph nodes, and unexplained body pain can also indicate an underlying condition requiring medical treatment.

These symptoms may point toward serious infections, immune system disorders, blood-related diseases, cancers, or inflammatory conditions in which the body's defense system triggers repeated inflammation without a clear infection.

Early Treatment For Better Outcomes

Another important warning sign is a fever that continues to recur despite treatment. According to Dr. Arora, repeated courses of antibiotics without a confirmed diagnosis should raise concern. In some cases, medications themselves can trigger fever, making a detailed medication history an important part of the evaluation.

The goal is not to panic but to seek timely medical assessment. Check for swollen lymph nodes, rashes, signs of infection, or evidence of systemic inflammation.

The experts noted that early medical evaluation can help identify the underlying cause, prevent complications, and ensure appropriate treatment. With timely diagnosis and proper management, many causes of recurrent fever can be effectively treated, allowing individuals to maintain their health and daily activities.

Tobacco use remains a global epidemic and one of the leading preventable causes of death worldwide. Despite a strong desire among many users to quit, relapse rates remain alarmingly high. A new study by researchers at the All India Institute of Medical Sciences (AIIMS), New Delhi, suggests that yoga could be a valuable tool in helping people quit tobacco.

Yoga Shows Promise for Tobacco Cessation

To evaluate the effectiveness of yoga in tobacco cessation, researchers led by Dr Gautam Sharma, Department of Cardiology and Centre for Integrative Medicine and Research, AIIMS, conducted a meta-analysis of five randomized controlled trials (RCTs) published up to September 2024.

The review included adults aged 18 years and older who used any form of tobacco, excluding vaping products. Participants were randomly assigned to yoga either as a standalone intervention or alongside conventional cessation treatments.

The primary outcome assessed was the 7-day point prevalence abstinence (7PPA), a standard measure of smoking cessation. Secondary outcomes included quality of life, depression, anxiety, and mood states.

The findings suggest that “yoga may serve as a moderately effective intervention for tobacco cessation, with an estimated effectiveness of around 50 per cent”, the team said in the paper.

Also read: Yoga May Boost Fertility And Hormonal Health In Women With PCOS

How Yoga May Help People Quit Tobacco

Researchers found that active yoga styles such as Hatha, Vinyasa, and Iyengar yoga improved abstinence rates by helping reduce stress, depression, and negative emotions often associated with tobacco withdrawal.

Pranayama, or yogic breathing exercises, was found to reduce cravings and negative affect, making it easier for participants to cope with withdrawal symptoms.

The review also highlighted the importance of addressing psychological factors linked to tobacco addiction, including perceived stress, anxiety, depression, and emotional distress—all of which are known contributors to relapse.

While some studies reported stronger psychological benefits than others, overall evidence suggests yoga may support emotional well-being during the quitting process.

Yoga and Tobacco Addiction

Also read: Yoga Shows Promise for Anxiety Relief And Seizure Control In Epilepsy, Claims Study

Researchers believe yoga may help manage tobacco addiction through several biological mechanisms.

Nicotine stimulates nicotinic cholinergic receptors in the brain, triggering the release of neurotransmitters that produce pleasurable and rewarding effects. During withdrawal, stress-related hormones increase, leading to anxiety, cravings, and emotional discomfort.

Yoga appears to counter these effects by shifting the body from a state of sympathetic nervous system dominance ("fight or flight") to parasympathetic dominance ("rest and digest").

Read More: India Launches New Yoga Protocols To Fight Diabetes, High BP, Asthma

This shift may reduce activity in the hypothalamic-pituitary-adrenal (HPA) axis, lower cortisol levels, and decrease stress hormone production, helping individuals better manage cravings and withdrawal symptoms.

The team also noted that controlled breathing techniques can significantly influence emotional regulation, with voluntary breath control accounting for substantial variations in emotional states such as anger, fear, and joy.

India alone has more than 270 million active tobacco users. Given the widespread use of smokeless tobacco in the region—and the limited effectiveness of standard cessation medications for these users—yoga could offer an accessible, culturally familiar, and low-cost complementary approach, the researchers stressed.

While the results are encouraging, researchers also cautioned that larger and more standardized studies are needed.

Every day, hospitals care for patients whose survival depends on a simple yet irreplaceable resource—donated blood. A mother experiencing severe bleeding after childbirth, a child with thalassemia requiring regular transfusions, a cancer patient undergoing chemotherapy, or a victim of a road traffic accident may all rely on timely access to safe blood.

Despite medical advances, blood remains unique. It cannot be manufactured or artificially replicated. It can only come from healthy individuals who choose to donate. This makes blood donation one of the most vital contributions a person can make to healthcare and society.

It is important to understand that the impact of a single donation extends far beyond what most people imagine.

One Donation, Multiple Patients

When a person donates whole blood, it is separated into components—red blood cells, platelets, and plasma. Each component serves a different purpose. Red blood cells carry oxygen and are essential in treating anemia and blood loss. Platelets help control bleeding and are critical for patients undergoing chemotherapy. Plasma contains proteins and clotting factors required for managing bleeding disorders.

Because these components can be used independently, a single donation has the potential to benefit multiple patients with different medical conditions. One act of donation can therefore support several lives.

Why Blood Supply Must Be Continuous

A common misconception is that blood is needed only during emergencies or disasters. In reality, the demand for blood is constant. Patients with chronic conditions such as thalassemia require regular transfusions throughout their lives. Cancer treatments, major surgeries, organ transplants, complicated pregnancies, and trauma care all depend on a steady and reliable blood supply.

Unlike many medical resources, blood components have limited shelf lives. Platelets can only be stored for a few days, and red blood cells have a defined storage period. This means blood stocks must be continuously replenished. A stable blood supply cannot be created overnight—it depends on regular and voluntary donations throughout the year.

The Importance Of Voluntary Donors

The safest and most reliable blood supply comes from voluntary donors who give blood without expectation of reward. However, maintaining this supply is an ongoing challenge. It requires not only recruiting new donors but also encouraging previous donors to return.

Many individuals who donate once do not return, often due to lack of awareness, time constraints, or fading motivation. Yet every regular donor begins as a first-time donor. A positive first donation experience plays a key role in building long-term commitment.

Hospitals, workplaces, and community organizations play a crucial role in promoting donation through awareness campaigns, outreach programs, and well-organized blood donation drives. Sustained engagement is essential to ensure that donors remain connected to this life-saving cause.

What Motivates People To Donate

Blood donation is not just a medical act—it is a powerful expression of social responsibility. Most donors never meet the individuals they help, yet they donate willingly to support someone in need. This anonymous act of giving reflects compassion, empathy, and a shared sense of humanity.

People are motivated to donate for many reasons. Some are driven by altruism and the desire to help others. Others are influenced by personal experiences, community values, or encouragement from family and peers. Awareness campaigns and social engagement can also play a significant role in shaping attitudes towards donation.

Understanding these motivations is important because it helps design more effective strategies to encourage both first-time and repeat donors.

Addressing Common Concerns

Despite its importance, many eligible individuals hesitate to donate due to fear or uncertainty. Concerns about pain, weakness, or safety are common. However, blood donation is a carefully regulated process conducted by trained healthcare professionals.

Donors undergo screening to ensure that the procedure is safe for both themselves and the recipient. The donation itself takes only a short time, and most people can resume normal activities soon afterward. Efforts to improve donor comfort and reduce anxiety have further enhanced the overall donation experience.

For many first-time donors, the greatest takeaway is a sense of satisfaction and pride in having contributed to saving lives.

Every First-Time Donor Matters

One of the greatest challenges in maintaining a stable blood supply is ensuring a continuous flow of new donors. As regular donors age or become ineligible, new volunteers are needed to sustain the system.

Encouraging first-time donors is therefore critical. With the right experience and awareness, a first-time donor can become a lifelong contributor, potentially helping dozens of patients over the years. Simple follow-up communication and continued engagement can significantly improve donor retention.

Families, educational institutions, workplaces, and healthcare providers all have a role to play in encouraging individuals to take this first step.

A Gift That Saves and Sustains Lives

Blood is more than a medical resource—it is a gift that cannot be bought, manufactured, or stored indefinitely. It represents hope, survival, and the generosity of one human being towards another.

Behind every successful surgery, every recovering patient, and every saved life, there is often an unseen donor whose contribution made that outcome possible.

A single donation may take only a few minutes, but its impact extends far beyond a single individual. It supports families, strengthens healthcare systems, and builds a culture of care and compassion within communities.

The message is simple: if you are eligible, consider donating. Your one unit of blood may help many—and could make the difference between life and loss for someone in need.