The COVID-19 pandemic may be over, but our immune systems are still feeling the impact. After years of battling constant viral threats, from COVID-19 to seasonal flu and other infections, our body’s defense system is exhausted. Many people continue to experience lingering inflammation, frequent illnesses, and slower recovery times. This extended state of immune stress has compromised us further to chronic illness, including autoimmune diseases and even neurodegenerative diseases such as Parkinson's. So why is our immune system still in trouble? And how do we give it its power back? Understanding immune exhaustion is the beginning of rebuilding our body's natural immunity.

A weakened immune system makes people more susceptible to disease, mental illnesses, and even sleep disorders. Now, new research indicates that immune system depletion may play an important role in the onset of Parkinson's disease, a degenerative neurologic disorder that compromises movement and cognition.

Role of Inflammation in Parkinson's Disease

Dysfunctional immune response is a leading cause of long-standing inflammation within the body, that has been found to contribute towards a multitude of conditions, including cardiovascular conditions, diabetes, depression, and neurodegenerative diseases such as Alzheimer's.

As people age, their immune system naturally becomes less effective. This deterioration, referred to as immune exhaustion, may be a key contributor to the onset and progression of Parkinson’s disease. Rebecca Wallings, a Parkinson’s Foundation Launch Award grant recipient and senior postdoctoral fellow at the University of Florida, believes that an accumulation of exhausted immune cells could be driving neurodegeneration in Parkinson’s patients.

How a Tired Immune System Might Affect Parkinson's?

Parkinson's disease is most commonly linked with the degeneration and loss of dopaminergic neurons—motor nerve cells that produce dopamine, an essential neurotransmitter for movement. While researchers have long suspected inflammation is involved in this neurodegeneration, the mechanisms are not yet well understood.

Wallings' study is on immune cell exhaustion, a process by which aging immune cells fail to control immune responses effectively. Her research indicates that instead of dampening inflammation in Parkinson's patients, attempts should be made to rejuvenate the immune system to regain its functionality.

Energy Deficiency in Immune Cells

One of the major findings of Wallings' work is the function of mitochondrial impairment in immune cell exhaustion. Mitochondria are commonly called the powerhouses of cells, as they are vital for generating energy. As mitochondria age and become inefficient, immune cells fail to function well, potentially accelerating neurodegeneration in Parkinson's disease.

Wallings has found that mutations in the LRRK2 gene, a recognized genetic risk factor for Parkinson's disease, are linked with defective mitochondrial function and immune cell exhaustion. Her current work includes testing various therapeutic approaches to restore mitochondrial function in immune cells with the potential to enhance the immune system and potentially prevent or treat Parkinson's disease.

Will Rejuvenating the Immune System Help in Treatment?

For decades, the standard practice in treating Parkinson's has been to suppress brain inflammation. Yet Wallings' work indicates that instead of slowing down immune responses, restoring the immune system could be a more successful strategy. By addressing mitochondrial impairment and immune resilience, researchers can potentially reverse or slow down Parkinson's disease.

Wallings is now looking into how to rejuvenate immune cells by fixing mitochondria. She studies immune cells from patients with Parkinson's as well as from healthy subjects and performs experiments on animal models to determine if rejuvenation of the immune system could result in improved disease outcomes.

Lifestyle Factors That May Affect Parkinson's Risk

While there is no cure for Parkinson's disease, some lifestyle adjustments may decrease the chances of developing the illness. Since neurodegenerative diseases are associated with chronic inflammation and immune dysfunction, developing habits that enhance immune function might prove helpful.

Diet: There is evidence to suggest that eating in accordance with the Mediterranean or MIND diets, both high in antioxidants, healthy fats, and anti-inflammatory foods, can encourage brain wellness and reduce Parkinson's risk.

Avoiding Dangerous Substances: Restricting alcohol and nicotine use can maintain a robust immune system and suppress inflammation.

Reducing Stress: Chronic stress weakens immune function, so methods such as meditation, exercise, and sufficient sleep can lead to improved overall well-being.

Students gaming more than 10 hours a week can have long-lasting negative effects on their physical and mental health, a new Australian study suggests.

Researchers from Curtin University, Perth have found that playing online games for over 10 hours can worsen diets, increase body weight and led to poorer sleep than lighter gamers.

Professor Mario Siervo, Curtin School of Population Health said of the results: "What stood out was students gaming up to 10 hours a week all looked very similar in terms of diet, sleep and body weight. The real differences emerged in those gaming more than 10 hours a week, who showed clear divergence from the rest of the sample."

What Did The Study Find?

Researchers surveyed 317 students across five Australian universities, with a median age of 20, to understand how time spent gaming each week might affect their diet, sleep, and body composition.

Students were categorized as low gamers (zero to five hours a week), moderate gamers (five to 10 hours) or high gamers, who played video games for more than 10 hours each week.

They found that low and moderate gamers showed largely comparable health outcomes but health indicators deteriorated sharply among students whose gaming time exceeded 10 hours a week.

The study found diet quality declined and obesity was more common once gaming exceeded 10 hours a week, with each extra hour linked to poorer diets even after accounting for other lifestyle factors. While high gamers recorded a body mass index (BMI) of 26.3kg/m2, low and moderate gamers fell within a healthier range, with median BMIs of 22.2kg/m2 and 22.8kg/m2 respectively.

Professor Siervo said: "Each additional hour of gaming per week was linked to a decline in diet quality, even after accounting for stress, physical activity and other lifestyle factors."

Additionally, sleep quality was generally poor across all groups but students who played video games for moderate or high amounts of time reported worse sleep than low gamers.

Despite clear results, the expert added that the study does not prove cause and effect but shows excessive gaming is linked to higher health risks, while low to moderate play appears largely fine.

Why Is Playing Video Games Bad For You?

"Our data suggests low and moderate gaming is generally fine, but excessive gaming may crowd out healthy habits such as eating a balanced diet, sleeping properly and staying active.

"Because university habits often follow people into adulthood, healthier routines such as taking breaks from gaming, avoiding playing games late at night and choosing healthier snacks may help improve their overall well-being," Professor Siervo said.

Playing video games for excessive amount of time has also been linked to paving the way for mental health problems such as anxiety, depression, aggression and poor emotional control as well as social/life problems including neglecting responsibilities, isolation, poor relationships, academic/career impact.

Moreover, previous research has also found that playing games for over three hours straight significantly raises the risk of physical issues. Sessions exceeding this time frame can lead to eye fatigue, headaches, neck pain and wrist pain, regardless of the player's age or gender.

This study was published in Nutrition on January 16.

Days after eagle-eyed fans spotted Nick Jonas stepping out of the Golden Globes during the Nikki Glaser-hosted show in Los Angeles, the popstar has now revealed what led to him there.

In an X video from January 11, Jonas was seen standing alone outside of a tent at the Beverly Hilton hotel surrounded by palm trees and green foliage, looking like he was taking a breather while sipping from a glass bottle of water and rubbing his chin.

As the clip began to go viral online, users shared their guess on why he had to exit the ceremony, commenting, "Social anxiety got the best of him." Soon after, he did reveal that he anxiety had "hit him like a gut punch" on X.

Living with Type 1 diabetes, Jonas has previously spoken about the emotional challenges of managing a chronic condition and how it has affected his life.

What Is Social Anxiety?

As explained by Dr Sanil Sinhasan, Consultant Psychiatrist at Mind Care Clinic and SRV Hospital, Mumbai, to Health Shots: "Social anxiety disorder is an intense fear of being judged, rejected, or embarrassed in social or performance situations.

"People with social anxiety often worry excessively about how they look, speak or are perceived by others."

This kind of anxiety is typically triggered by meeting new people, public speaking or even everyday interactions like eating in public, stemming from fears of negative evaluation by others.

Symptoms include blushing, sweating, trembling, rapid heartbeat, nausea, dizziness, trouble speaking, stomach issues. If left untreated, social anxiety can become debilitating as it can also cause fast, shallow breathing, muscle tension, suffocation, symptoms that can intensify anxiety further and lead to serious medical events.

How To Overcome Social Anxiety?

Professional therapies such as Cognitive Behavioral Therapy (CBT) and medication such as antidepressants (SSRIs/SNRIs) can offer deeper solutions for managing fear and building skills.

Regular physical activity can also help release endorphins and reduce tension as well avoiding excess caffeine can support mental health.

Mental health experts also recommend opening up to loved ones and avoiding isolation. Speaking to loved ones and sharing how you’re feeling can help ensure your current state doesn’t aggravate.

Doctors also advise speaking therapist if social anxiety significantly impacts your life as professional help is crucial for lasting change.

Wondering if abnormal bleeding, pelvic pain and leg swelling are signs of something fatal?

According to Dr Ninad Katdare, Consultant Surgical Oncologist, Jaslok Hospital & Research Centre, they may be symptoms of cervical cancer. While many may expect drastic signs such as severe pain, heavy bleeding or obvious illness, identifying certain symptoms can help with early diagnosis and treatment.

Cervical cancer develops in a women's cervix (uterus opening) due to abnormal cell growth, primarily caused by persistent HPV infection, a common infection that's passed through sexual contact.

When exposed to HPV, the body's immune system typically prevents the virus from causing damage however, in a small percentage of people, the virus can survive for years and pave the way for some cervical cells to become cancerous.

Treatment involves surgery, radiation, and chemotherapy, with early detection significantly improving outcomes, though it remains a major cancer in low-income countries. Cervical cancer can also be prevented through vaccination and regular screening (Pap/HPV tests).

Dr Katdare told News18: "In its early stages, it is often more of a whisper than a shout. As a cancer surgeon who has treated hundreds of women with gynaecological cancers, I can say with confidence that recognising these subtle cues can lead to earlier diagnosis and significantly better outcomes."

He recommends looking out for these early signs:

1. Intermenstrual Bleeding

2. Changes In Vaginal Discharge

But Dr Katdare warns that any sudden or abnormal changes in discharge may be a symptom of the cancer. “Because discharge issues are commonly linked to infections, many women self-medicate or delay seeking care," he said. “While infections are far more common, chronic or unusual discharge especially in older women requires thorough evaluation."

Discharge may become persistent, watery, foul-smelling, or tinged with blood or pink, brown, or rust-colored if you're suffering from this kind of cancer.

3. Persistent Pelvic Pain

Consistent pelvic pain particularly that occurs outside the menstrual cycle or during sexual intercourse should be a point of concern. According to Dr Katdare, "Pain during intercourse, or dyspareunia, is especially important. It should not be dismissed as ‘just dryness’ or an age-related change. In cervical cancer, this pain may result from inflammation or tumour growth involving the cervix and surrounding tissues."

4. Leg Swelling

5. Urinary And Bowel Symptoms

“These symptoms are often evaluated in isolation because they don’t seem related to the cervix," said Dr Katdare, “which can delay the correct diagnosis."

Ultimately the expert advised: "“Cervical cancer does not always announce itself loudly,. Sometimes, it leaves silent clues. The sooner you listen to them, the better the outcome. If something feels ‘off,’ trust that instinct and seek medical advice. Early action can make the difference between a curable disease and a life-altering diagnosis."