A 'Tired' Immune System Could Be A Latent Trigger For Parkinson’s Disease

Updated Mar 1, 2025 | 09:25 AM IST

SummaryParkinson’s disease affects over 10 million people worldwide, with 60,000 new cases diagnosed annually in the U.S. Research suggests immune system exhaustion and chronic inflammation may contribute to neurodegeneration in Parkinson’s patients.
Is A 'Tired' Immune System The Hidden Trigger For Parkinson’s Disease?

The COVID-19 pandemic may be over, but our immune systems are still feeling the impact. After years of battling constant viral threats, from COVID-19 to seasonal flu and other infections, our body’s defense system is exhausted. Many people continue to experience lingering inflammation, frequent illnesses, and slower recovery times. This extended state of immune stress has compromised us further to chronic illness, including autoimmune diseases and even neurodegenerative diseases such as Parkinson's. So why is our immune system still in trouble? And how do we give it its power back? Understanding immune exhaustion is the beginning of rebuilding our body's natural immunity.

A weakened immune system makes people more susceptible to disease, mental illnesses, and even sleep disorders. Now, new research indicates that immune system depletion may play an important role in the onset of Parkinson's disease, a degenerative neurologic disorder that compromises movement and cognition.

Role of Inflammation in Parkinson's Disease

Dysfunctional immune response is a leading cause of long-standing inflammation within the body, that has been found to contribute towards a multitude of conditions, including cardiovascular conditions, diabetes, depression, and neurodegenerative diseases such as Alzheimer's.

As people age, their immune system naturally becomes less effective. This deterioration, referred to as immune exhaustion, may be a key contributor to the onset and progression of Parkinson’s disease. Rebecca Wallings, a Parkinson’s Foundation Launch Award grant recipient and senior postdoctoral fellow at the University of Florida, believes that an accumulation of exhausted immune cells could be driving neurodegeneration in Parkinson’s patients.

How a Tired Immune System Might Affect Parkinson's?

Parkinson's disease is most commonly linked with the degeneration and loss of dopaminergic neurons—motor nerve cells that produce dopamine, an essential neurotransmitter for movement. While researchers have long suspected inflammation is involved in this neurodegeneration, the mechanisms are not yet well understood.

Wallings' study is on immune cell exhaustion, a process by which aging immune cells fail to control immune responses effectively. Her research indicates that instead of dampening inflammation in Parkinson's patients, attempts should be made to rejuvenate the immune system to regain its functionality.

Energy Deficiency in Immune Cells

One of the major findings of Wallings' work is the function of mitochondrial impairment in immune cell exhaustion. Mitochondria are commonly called the powerhouses of cells, as they are vital for generating energy. As mitochondria age and become inefficient, immune cells fail to function well, potentially accelerating neurodegeneration in Parkinson's disease.

Wallings has found that mutations in the LRRK2 gene, a recognized genetic risk factor for Parkinson's disease, are linked with defective mitochondrial function and immune cell exhaustion. Her current work includes testing various therapeutic approaches to restore mitochondrial function in immune cells with the potential to enhance the immune system and potentially prevent or treat Parkinson's disease.

Will Rejuvenating the Immune System Help in Treatment?

For decades, the standard practice in treating Parkinson's has been to suppress brain inflammation. Yet Wallings' work indicates that instead of slowing down immune responses, restoring the immune system could be a more successful strategy. By addressing mitochondrial impairment and immune resilience, researchers can potentially reverse or slow down Parkinson's disease.

Wallings is now looking into how to rejuvenate immune cells by fixing mitochondria. She studies immune cells from patients with Parkinson's as well as from healthy subjects and performs experiments on animal models to determine if rejuvenation of the immune system could result in improved disease outcomes.

Lifestyle Factors That May Affect Parkinson's Risk

While there is no cure for Parkinson's disease, some lifestyle adjustments may decrease the chances of developing the illness. Since neurodegenerative diseases are associated with chronic inflammation and immune dysfunction, developing habits that enhance immune function might prove helpful.

Diet: There is evidence to suggest that eating in accordance with the Mediterranean or MIND diets, both high in antioxidants, healthy fats, and anti-inflammatory foods, can encourage brain wellness and reduce Parkinson's risk.

Avoiding Dangerous Substances: Restricting alcohol and nicotine use can maintain a robust immune system and suppress inflammation.

Reducing Stress: Chronic stress weakens immune function, so methods such as meditation, exercise, and sufficient sleep can lead to improved overall well-being.

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Times Network India Health Summit 2026 Key Takeaways: AI, Fertility, AYUSH, Cancer Care & More

Updated Oct 28, 2026 | 11:57 PM IST

SummaryThe Times Network India Health Summit 2026 featured several informative and insightful knowledge sessions and panel discussions on subjects like AI in healthcare, advancement in healthcare technologies, AYUSH, cancer care and more.
Times Network India Health Summit 2026 Key Takeaways: AI, Fertility, AYUSH, Cancer Care & More

Credit: Times Network

The Times Network India Health Summit 2026 brought together policymakers, clinicians, researchers and healthcare industry leaders to discuss the future of India's healthcare system, with conversations spanning medical innovation, access to treatment, mental health, women's health and preventive care.

The third edition of the Times Network India Health Summit & Awards was held in New Delhi on October 28 under the theme, The Blueprint for a Future-Ready Healthcare Ecosystem: Innovation. Access. Self-Reliance.

From the use of artificial intelligence (AI) in diagnostics to advances in fertility treatment and the need to strengthen public health infrastructure, various sessions explored several aspects of how healthcare delivery could evolve. Here are the key discussions and takeaways from the summit.

Anupriya Patel Highlights India's Healthcare Priorities Including Ayushman Bharat Coverage

Union Minister of State for Health and Family Welfare Anupriya Patel addressed the summit on building a future-ready healthcare ecosystem. With around 500 Ayushman Bharat cards issued, Patel also said that 132.5 million people had received free treatment under the scheme.

She also addressed India's Viksit Bharat 2047 vision, stating that Union health budget increased from around Rs 37,000 crore in 2014 to more than Rs 1.06 lakh crore.

Also read: Infertility Affects 1 In 6 Couples: Experts Highlight Age, IVF Costs & Male Fertility At Times Health Summit 2026

Delhi Health Minister Dr. Pankaj Singh Addressed Air Pollution Crisis

Delhi Health Minister Pankaj Singh answered key questions about the city’s looming air pollution crisis. He said that the government's various pollution-control measures, including electric vehicle (EV) policy can help fight it. He also spoke about the need for long-term solutions.

Union Minister of State (Independent Charge) AYUSH Prataprao Jadhav, Madhya Pradesh Minister of State Narendra Shivaji Patel and Uttarakhand Cabinet Minister Subodh Uniyal, were also scheduled to address different aspects of healthcare policy and delivery.

Padma Bhushan Dr S K Sarin On Liver Health

Padma Bhushan Dr Shiv Kumar Sarin, leading hepatologist, gastroenterologist, and medical educator who also serves as the Senior Professor, Chancellor, and Director of the Institute of Liver and Biliary Sciences (ILBS), recently spoke about the dos and don’ts to maintain a healthy liver at the Times Health Summit 2026.

From ideal breakfast time to late night eating, the expert spoke about common lifestyle mistakes people make that could worsen their liver health.

Also read: Unspoken Side Of Breast Cancer: Experts Discuss Recurrence Risk, Emotional Toll & Societal Impact At Times Health Summit 2026

Need For Investment In Ayurveda & AYUSH Sector

The session From Tradition to Therapeutics: The New Science of AYUSH was based on the role of traditional medicine in India's healthcare landscape.

Dr Biswaroop Roy Chowdhury, Founder of BRC Clinics Health, and Dr Tanmay Goswami, Founder of Goswal, discussed Ayurveda, its potential applications and questions surrounding its integration with modern medicine.

The speakers spoke about Ayurveda’s scientific research, evidence, AYUSH funding, clinical applications and integration with western medicine. The experts said that Ayurveda sector is valued at approximately $17–18 billion, while China's traditional medicine sector is estimated at around $30 billion, calling for greater investment in the sector.

Mental Health: Suicide Risk, Screen Addiction & More

Mental healthcare was another focus, with Dr Deepak Kumar, Professor and Head of the Department of Psychiatry at the Institute of Human Behaviour and Allied Sciences (IHBAS), discussing The Next Frontier in Indian Psychiatry: Specialization, Geriatric Mental Health, and De-addiction Strategies.

The doctor discussed immediate threat of suicidal thoughts, warning behavioural signs, screen addiction and need for parents to supervise and limit screen use in children.

Also read: Leading Gastroenterologist Padma Bhushan Dr S K Sarin Shares Dos & Don’ts For Healthy Liver At Times Health Summit 2026

Aftermath Breast Cancer Diagnosis & Treatment

Women's health was featured prominently at the summit, with the knowledge session Take Charge Together: Shaping a Future of Greater Breast Cancer Awareness and Better Outcomes.

The session featured Dr Meenu Walia, Chairman of Medical Oncology at Max Healthcare; Vaishali Iyer, Country Head of Communications, Patient Advocacy and CSR at Novartis in India; and Dr Pankaj Goyal, Senior Consultant and Unit Head of Medical Oncology at Rajiv Gandhi Cancer Institute.

The experts focused on the risk of recurrence, the emotional toll of breast cancer treatment, financial and societal hardships, body image issues, intimacy problems and other challenges patients face after leaving the hospital.

Fertility Treatment And Parenthood

The panel The Fertility Revolution: Reimagining Parenthood in Modern India spoke about the evolving field of reproductive medicine and the challenges faced by people seeking fertility treatment.

The speakers included Dr Ranjana Sharma, Senior Consultant in Obstetrics and Gynaecology at Indraprastha Apollo Hospital; Dr Vimal Grover, Senior Director of Obstetrics and Gynaecology at Fortis LaFemme; Dr Hrishikesh Pai, Founder and Managing Director of Bloom IVF India; and Dr Abha Majumdar, Emeritus Consultant in IVF and Human Reproduction at Sir Ganga Ram Hospital.

The session brought attention to fertility preservation, IVF costs, male infertility, stigma women face, and the judgments that come with seeking IVF for starting a family.

Also read: Experts Discuss Ayurveda For Treating Lifestyle Disorders, Medical Emergencies & Trauma At Times Health Summit 2026

Why Menopause Is A Long-Overlooked Health Issue

The session From Silence to Care: Why India Can No Longer Ignore Menopause focused on menopause and the need to bring greater attention to women's health during midlife.

The session was led by Sanjith Shetty, Founder and CEO of Miror. He spoke about the suicide rates among menopausal women, along with other life challenges like divorces, retirements, and social isolation.

Digging Deeper Into Longevity Science

The fireside chat From LifeSpan to HealthSpan: Can Science Help Us Live Longer and Better? explored the science of longevity and the difference between living longer and maintaining good health for more years.

The conversation featured Dr Chirantan Bose and Dr Preetesh Bhandari, founders of Vytalyou. They spoke about the importance of maintaining muscle health, monitoring neurological health, and warding off lifestyle diseases like obesity and diabetes.

Other Sessions

The role of technology in modern medicine was explored in Precision Diagnostics: AI, Genomics & The New Era Of Personalized Care. The panel featured Dr Arjun Dang, CEO and Partner at Dr Dangs Lab; Dr Manish Vaish, Director and Head of the Institute of Neurosciences at Medanta, Noida; and Dr Belal Bin Asaf, Director of the Institute of Chest Surgery, Chest Onco-Surgery and Lung Transplant at Medanta, Noida.

The discussion focused on the evolving role of artificial intelligence and genomics in diagnostics, personalised treatment and improving diagnostic accuracy.

The future of specialised medical services was examined in The Next Frontier of Advanced Care: Scaling Capacity, Innovation & Clinical Excellence. The session brought together Dr V.S. Chauhan, Chairman and Managing Director of Prakash Hospitals and Institutions, and Prof. Dr Sanjeev Bagai, Chairman of Nephron Clinic.

The discussion centred on expanding advanced healthcare capacity, strengthening clinical excellence and leveraging innovation and technology to improve patient outcomes while making specialised treatment more accessible.

Addressing the challenges of equitable healthcare delivery, Reengineering Public Health Infrastructure: Last-Mile Delivery, Digital Health Equity, and Rural Access brought together Dr Anoop Saraya of the Institute of Liver & Biliary Sciences; Dr Charu Dutt Arora of AmeriHealth Home Healthcare, Asian Institute of Medical Sciences; Dr Gyanendra Kumar of Maulana Azad Institute of Dental Sciences; Girish Krishnamurthy, CEO of Tata Medical & Diagnostics; and Dr Jyoti Wadhwa of Apollo Athenaa Women's Cancer Centres.

The session focused on strengthening public health infrastructure, improving rural and last-mile access, and exploring the role of digital health and healthcare delivery models in bridging gaps in access to medical services.

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Unspoken Side Of Breast Cancer: Experts Discuss Recurrence Risk, Emotional Toll & Societal Impact At Times Health Summit 2026

Updated Oct 28, 2026 | 08:59 PM IST

SummaryAt the Times Network India Health Summit and Awards 2026 in New Delhi, experts discussed the aftermath of breast cancer diagnosis and treatment.
Unspoken Side Of Breast Cancer: Experts Discuss Recurrence Risk, Emotional Toll & Societal Impact At Times Health Summit 2025

Credit: Times Network

The journey of a breast cancer patient does not end when their treatment comes to a conclusion. There is always a risk of recurrence, which makes regular follow-ups and adherence to treatment important.

At the Times Network India Health Summit and Awards 2026 in New Delhi, a panel formed by Dr Priya Parmar, Chief Operating Officer, Indian Cancer Society, Delhi, Dr. Jyoti Wadhwa - Principal Lead of Medical and Precision Oncology, Apollo Athena Women’s Cancer Centres, New Delhi and Apollo Hospital, Gurgaon, Dr. Meenu Walia, Chairman Medical Oncology, Max Healthcare, Dr Pankaj Goyal, Sr Consultant and Unit Head, Medical Oncology, RGCI, and Vaishali Iyer, Country Head, Communications, Patient Advocacy and CSR, Novartis in India, discussed the big picture after breast cancer treatment.

During a panel discussion titled “Take Charge Together: Shaping a Future of Greater Breast Cancer Awareness and Better Outcomes,” experts highlighted the physical, emotional, social and financial challenges that women may continue to face after treatment among many more.

What Comes After Breast Cancer Treatment?

For many women, the period after breast cancer can involve more than medical monitoring. They may face fatigue, menopausal symptoms and changes in body image after undergoing a major physical change, while concerns about intimacy, fertility and relationships can affect emotional and mental well-being.

Dr. Priya Parmar highlighted how losing a breast or hair can affect a woman's sense of identity and femininity. Some survivors also face social stigma related to marriage and fertility, while sexual health and relationship concerns may remain difficult to discuss.

The burden can be greater for women who lack family support or have limited financial resources. These circumstances may affect not only emotional recovery but also their ability to attend follow-up appointments and continue treatment.

The financial strain can become particularly difficult if cancer returns and further investigations or treatment are required.

Dr. Meenu Walia said that treatment for advanced disease can add to the economic burden faced by patients and their families.

Also read: Vanessa Trump Recovers From 'Very Invasive' Breast Cancer, Reveals Early Sign Of The Disease

Risk Of Recurrence

The risk of breast cancer recurrence is not the same for every patient. It depends on the cancer's stage and subtype, tumour grade, lymph node involvement, response to treatment and whether treatment is timely.

Dr. Jyoti Wadhwa explained that different breast cancer subtypes can follow different recurrence patterns.

Triple-negative breast cancer tends to recur earlier, often within the first two to three years after treatment. Hormone receptor-positive, HER2-negative breast cancer, however, can return even 10 to 20 years later.

She also said that patients who achieve a pathological complete response after treatment given before surgery may have a lower risk of recurrence than those with residual disease.

However, a lower estimated risk does not mean the risk is eliminated. Continued monitoring is important even for patients who have responded well to treatment.

Also read: Beyond the Lump: Overlooked Breast Cancer Symptoms That Can Delay Diagnosis

Feeling Better Is Not A Reason To Skip Follow-Ups

One concern raised by the experts was that some patients stop taking prescribed oral hormone therapy or miss appointments after their symptoms improve.

“Your first attempt at treatment is always your best attempt,” Dr. Walia said, underlining the importance of appropriate diagnosis and treatment from the outset.

Follow-up care helps doctors monitor a patient's recovery, assess treatment-related effects and make decisions based on individual clinical circumstances. The appropriate schedule and any further treatment depend on the patient's diagnosis, risk profile and medical history.

Experts also cautioned against allowing the possibility of recurrence to dominate a survivor's life. Understanding individual risk should help patients make informed decisions, rather than leave them in constant fear that cancer will return.

Post-Treatment Care Needs More Than Medical Monitoring

The long-term effects of breast cancer also have implications beyond the individual patient. Vaishali Iyer, Country Head of Communications, Patient Advocacy and CSR at Novartis in India, highlighted an estimated 140 million productive hours lost due to breast cancer care, drawing attention to its wider economic impact.

Dr. Wadhwa emphasised the need to address treatment-related concerns, including menopausal symptoms and bone health, which may require attention even after primary cancer treatment has ended.

Dr. Pankaj Goyal, Senior Consultant and Unit Head of Medical Oncology at RGCI, stressed that doctors must build trust with patients and explain recurrence risks without causing unnecessary alarm. Discussions about care should also account for patients' personal circumstances and financial constraints.

The panel discussion, titled “Take Charge Together: Shaping a Future of Greater Breast Cancer Awareness and Better Outcomes,” took place at the Times Network India Health Summit and Awards 2026.

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Leading Gastroenterologist Padma Bhushan Dr S K Sarin Shares Dos & Don’ts For Healthy Liver At Times Health Summit 2026

Updated Oct 28, 2026 | 04:02 PM IST

SummaryPadma Bhushan Dr Shiv Kumar Sarin spoke about lifestyle habits that could worsen liver health at the Times Health Summit 2026.
Leading Gastroenterologist Padma Bhushan Dr S K Sarin Shares Dos & Don’ts For Healthy Liver At Times Health Summit 2026

Credit: Times Health Summit 2026

Padma Bhushan Dr Shiv Kumar Sarin, leading hepatologist, gastroenterologist, and medical educator who also serves as the Senior Professor, Chancellor, and Director of the Institute of Liver and Biliary Sciences (ILBS), recently spoke about the dos and don’ts to maintain a healthy liver at the Times Health Summit 2026.

Held under the theme “The Blueprint for a Future-Ready Healthcare Ecosystem – Innovation. Access. Self-Reliance,” the summit brought together healthcare professionals and industry stakeholders to discuss innovation, access to treatment and policy approaches shaping India's healthcare sector.

Should You Drink Hot Water In The Morning For Bowel Movement?

The doctor addressed the daily morning ritual of drinking hot water in the morning, which a lot of people follow to release bowels.

Dr Sarin said, “Don't use hot water or anything for that matter to make you go to the toilet because it is the connection between the brain and the bowel that is very important.

He also spoke about opting for other drinks like coconut water or lemon water with honey. He said that lemon can help improve iron absorption in your body.

He added, “As per coconut water is concerned, it has potassium which is very good for your bowel health but it should still not be an everyday thing. For nimbu and honey, you should remember that honey has fructose. So if you are consuming honey, you also need to churn that out."

Also read: Fatty Liver Disease: Scientists Identify 5 Subtypes With Different Health Risks

Ideal Time for Breakfast

Many of us do not know what is the right time for breakfast. It is especially important as eating after fasting for eight to ten hours affects your energy and metabolic health throughout the day.

Dr Sarin said, "It's after sunrise. Minimum 12 hours after the last food that you have eaten. Ussay pehle galti nahi kariyega khaanay ki. Let the stomach, and the bacteria and the intestine recover."

He also spoke about whether you should have fruits for breakfast. "Breakfast should be fruits. And, low calories fruits. Avoid carbs."

Also read: The Changing Obesity Treatment Landscape: Where Does Bariatric Surgery Fit in the Age of Weight-Loss Drugs?

How Coffee Affects The Liver

There is a lot of information as well as misinformation about coffee consumption and liver health. Dr S K Sarin spoke in its favour and said that it could prevent a lot of liver conditions.

He said, "It does many things. it clears several toxic things including fat, clears the flow of bile, good enzyme inducer, prevents fibrosis of the liver and can decrease cirrhosis and also the development of liver cancer."

He also warned ignoring healthy dietary habits and simply relying on coffee is also not ideal. He added, "Coffee is not medicine, it is something which can help you prevent and not treat."

Is Your Lunch Completely Healthy?

Dr Sarin also warned against eating more amount carbohydrates than the recommended limit. He explained how sitting next to an obese person can make you feel physically lethargic as their breath may emit endogenous alcohol.

When you eat a carbohydrate-heavy meal, your digestive system breaks down carbohydrates into sugars. Certain microorganisms in the gut, including yeasts and some bacteria, can ferment these sugars and produce small amounts of ethanol, or alcohol. This is known as endogenous alcohol production.

Dr Sarin recommends eating low-carb meals for lunch like sprouts, vegetables, yoghurt, buttermilk or low-sugar fruits.

Late-Night Eating Is A Red Flag

Dr Sarin recommends having dinner before sunset. He also said that having late-night dinners could disrupt your sleep.

He added, "Obesity during youth increases the risk of heart disease later in life. After the age of 40, eating one meal a day may have health implications. The total daily calorie intake should not exceed 300–400. Avoid eating late at night. Eating late can also affect your insulin resistance."

Yearly Screening To Keep Liver Health In Check

Dr Sarin also said that thin people can also have unhealthy fat that may cause fatty liver. He recommended yearly screens to keep liver health in check.

He said, "Even thin people can have excess body fat and low muscle mass, which may affect their health. Being thin does not necessarily mean being healthy. Maintaining good muscle mass is important."

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