The COVID-19 pandemic may be over, but our immune systems are still feeling the impact. After years of battling constant viral threats, from COVID-19 to seasonal flu and other infections, our body’s defense system is exhausted. Many people continue to experience lingering inflammation, frequent illnesses, and slower recovery times. This extended state of immune stress has compromised us further to chronic illness, including autoimmune diseases and even neurodegenerative diseases such as Parkinson's. So why is our immune system still in trouble? And how do we give it its power back? Understanding immune exhaustion is the beginning of rebuilding our body's natural immunity.

A weakened immune system makes people more susceptible to disease, mental illnesses, and even sleep disorders. Now, new research indicates that immune system depletion may play an important role in the onset of Parkinson's disease, a degenerative neurologic disorder that compromises movement and cognition.

Role of Inflammation in Parkinson's Disease

Dysfunctional immune response is a leading cause of long-standing inflammation within the body, that has been found to contribute towards a multitude of conditions, including cardiovascular conditions, diabetes, depression, and neurodegenerative diseases such as Alzheimer's.

As people age, their immune system naturally becomes less effective. This deterioration, referred to as immune exhaustion, may be a key contributor to the onset and progression of Parkinson’s disease. Rebecca Wallings, a Parkinson’s Foundation Launch Award grant recipient and senior postdoctoral fellow at the University of Florida, believes that an accumulation of exhausted immune cells could be driving neurodegeneration in Parkinson’s patients.

How a Tired Immune System Might Affect Parkinson's?

Parkinson's disease is most commonly linked with the degeneration and loss of dopaminergic neurons—motor nerve cells that produce dopamine, an essential neurotransmitter for movement. While researchers have long suspected inflammation is involved in this neurodegeneration, the mechanisms are not yet well understood.

Wallings' study is on immune cell exhaustion, a process by which aging immune cells fail to control immune responses effectively. Her research indicates that instead of dampening inflammation in Parkinson's patients, attempts should be made to rejuvenate the immune system to regain its functionality.

Energy Deficiency in Immune Cells

One of the major findings of Wallings' work is the function of mitochondrial impairment in immune cell exhaustion. Mitochondria are commonly called the powerhouses of cells, as they are vital for generating energy. As mitochondria age and become inefficient, immune cells fail to function well, potentially accelerating neurodegeneration in Parkinson's disease.

Wallings has found that mutations in the LRRK2 gene, a recognized genetic risk factor for Parkinson's disease, are linked with defective mitochondrial function and immune cell exhaustion. Her current work includes testing various therapeutic approaches to restore mitochondrial function in immune cells with the potential to enhance the immune system and potentially prevent or treat Parkinson's disease.

Will Rejuvenating the Immune System Help in Treatment?

For decades, the standard practice in treating Parkinson's has been to suppress brain inflammation. Yet Wallings' work indicates that instead of slowing down immune responses, restoring the immune system could be a more successful strategy. By addressing mitochondrial impairment and immune resilience, researchers can potentially reverse or slow down Parkinson's disease.

Wallings is now looking into how to rejuvenate immune cells by fixing mitochondria. She studies immune cells from patients with Parkinson's as well as from healthy subjects and performs experiments on animal models to determine if rejuvenation of the immune system could result in improved disease outcomes.

Lifestyle Factors That May Affect Parkinson's Risk

While there is no cure for Parkinson's disease, some lifestyle adjustments may decrease the chances of developing the illness. Since neurodegenerative diseases are associated with chronic inflammation and immune dysfunction, developing habits that enhance immune function might prove helpful.

Diet: There is evidence to suggest that eating in accordance with the Mediterranean or MIND diets, both high in antioxidants, healthy fats, and anti-inflammatory foods, can encourage brain wellness and reduce Parkinson's risk.

Avoiding Dangerous Substances: Restricting alcohol and nicotine use can maintain a robust immune system and suppress inflammation.

Reducing Stress: Chronic stress weakens immune function, so methods such as meditation, exercise, and sufficient sleep can lead to improved overall well-being.

While alcohol consumption is known to be harmful to health, a new study has linked it to 62 disorders ranging from heart and digestive diseases to mental and neurological conditions and cancers.

The study, published in the journal Addiction, showed that the fully alcohol-attributable conditions are mainly grouped under non-communicable diseases and injuries. These include endocrine, nutritional, and metabolic diseases, mental and behavioral disorders, diseases of the nervous system, diseases of the circulatory system, such as alcoholic cardiomyopathy, and digestive diseases, including alcoholic liver disease and cirrhosis.

The latest data also adds psychotic disorders, gastritis, ulcers, pancreatitis, fatty liver disease, pregnancy- and perinatal-related conditions such as fetal alcohol syndrome and fetal alcohol spectrum disorders, as well as external causes and injuries, including alcohol poisoning.

“These conditions are 100 per cent alcohol attributable, meaning these diseases would not even exist in the world without alcohol use,” said Jürgen Rehm, senior scientist at the Institute for Mental Health Policy Research in Toronto and part of the study team, according to CNN.

“There are another 30 diseases in which alcohol plays a role, such as breast and other cancers, heart disease, stroke, diabetes, and dementia,” Rehm said. “These diseases would exist even without alcohol use, but alcohol use is responsible for a certain proportion of them.”

How The Study Identified Alcohol-Related Diseases

The diseases and injury categories fully attributable to alcohol were identified using the World Health Organization (WHO) International Statistical Classification of Diseases and Related Health Problems, 10th (ICD-10) and 11th (ICD-11) revision databases.

The study defines heavy drinking as more than 40 g of pure alcohol a day for women and 60 g a day for men. This translates to about 1.4 ounces of liquor for women and 2.1 ounces for men.

The good news, researchers said, is that many of these health effects can be slowed, stopped, or even reversed.

“Fortunately, the immediate effects of alcohol on the immune system don’t last long. Depending on levels of consumption, the body bounces back within days to a week,” Rehm said.

Alcohol And Cancer Risk

Also read: Antidepressant Use During Pregnancy Not Linked To Autism, ADHD, Finds Lancet Study

In 2025, former US Surgeon General Dr. Vivek Murthy released a new Surgeon General Advisory on alcohol and cancer risk, highlighting the direct link between alcohol consumption and increased cancer risk.

Similar to warning labels on cigarettes, the Surgeon General called for cancer risk warnings on alcohol products.

The report released by the US Surgeon General’s office identified at least seven types of cancer associated with alcohol consumption. It also recommended updating alcohol labels to include cancer warnings and reassessing guideline limits for alcohol consumption.

The cancers linked to alcohol consumption that Murthy recommended should be included on warning labels:

• Breast cancer
• Colon cancer
• Throat cancer
• Liver cancer
• Voice box cancer
• Esophageal cancer
• Mouth cancer.

Amid India's growing burden of high blood pressure among the youth, Prataprao Jadhav, Union Minister of State (I/C), Ministry of Ayush and Minister of State for Health and Family Welfare, said hypertension is emerging as a major public health concern due to worsening lifestyle habits.

High blood pressure is a “silent killer” that is rapidly increasing among India’s youth because of unhealthy lifestyle changes, the minister said.

Hypertension Rising Rapidly Among Young Indians

Ahead of World Hypertension Day 2026, Jadhav noted that the condition often progresses without visible symptoms and can eventually lead to severe complications such as heart attacks and strokes.

“In today’s time, it is essential that we make our communities more sensitive and aware and strengthen awareness about hypertension. Due to changing lifestyles and reduced attention to physical and mental health, hypertension is rapidly increasing even among the youth,” Jadhav said in a video message during the ‘Illness to Wellness Conference on Transforming Hypertension Care: Prevention to Wellness’ organized in the national capital.

He highlighted that the Government of India, under the National Program for Prevention and Control of Non-Communicable Diseases (NPCDCS), is actively promoting population-based screening, early detection, and management through Health and Wellness Centers across the country.

Modern Lifestyle Habits Increasing Hypertension Risk

Prof. Rakesh Yadav, Cardiologist and head of the Department of Emergency Medicine at AIIMS, New Delhi, stated that once known to be the disease of the elderly, hypertension is now more common among the youth. The reason — lifestyle changes, the experts said.

“The biggest problem is that despite increasing awareness, people still do not monitor their blood pressure regularly or continue treatment consistently. Hypertension is no longer limited to the affluent or elderly; it is now affecting all sections of society, including children and young adults,” said Prof. Rakesh Yadav, Cardiologist and head of the Department of Emergency Medicine, AIIMS, New Delhi.

“Obesity remains one of the major underlying causes, and regular monitoring of blood pressure and sugar levels, affordable lifelong medication, healthy dietary practices, and weight management are essential to reducing mortality associated with hypertension and related diseases,” he added.

In India, more than 1 in 4 people have hypertension, and cumulatively, more than 90% of adults with hypertension are either undiagnosed, untreated, or treated but live with uncontrolled hypertension.

Experts at the conference also pointed out that modern lifestyles marked by long working hours, constant connectivity, poor sleep, sedentary habits, and rising stress levels are significantly contributing to the growing burden of hypertension and other lifestyle disorders.

Another major concern, they said, is that many people tend to ignore early symptoms until complications arise, negatively affecting treatment outcomes.

“Hypertension is one of the biggest public health challenges today because most people do not take it seriously until complications arise. Nearly one in four adults is affected by hypertension, yet awareness and blood pressure control remain very low,” said Dr. Ripen Gupta, Vice Chairman & Unit Head - Cardiology, Max Smart Super Speciality Hospital, Saket.

Rajesh Bhushan, Former Secretary, Ministry of Health & Family Welfare, said high blood pressure is not limited to urban populations and is increasingly affecting youth in rural India as well.

“The problem of hypertension is as prevalent in rural India as it is in urban India, but because we live in metro cities, we often believe it is only an urban problem. Early detection is extremely important because without early detection, early treatment becomes difficult,” Bhushan said.

Experts Stress Early Detection And Preventive Care

Bushan stated that non-communicable diseases impact GDP significantly across countries, and therefore, prevention and timely intervention are critical.

Hypertension should never be taken lightly, said Dr. Sanjeev Singh, Chairperson, FICCI Medical Education Task Force and Medical Director, Amrita Institute of Medical Sciences & Research Centre. He urged people to follow medical advice seriously to avoid long-term complications.

The doctors called for critical lifestyle interventions for prevention and management. This included:

• annual BP screening,
• aerobic exercise,
• resistance training,
• reduced desk time,
• proper sleep,
• yoga,
• meditation,
• monitoring BMI and waist circumference.

High blood pressure, or hypertension, is often called a “silent killer” because it may cause no symptoms, but serious damage to multiple organs can occur. Most people associate hypertension only with heart attacks, but its ill effects extend far beyond the heart. Persistent high blood pressure can gradually damage the brain, kidneys, eyes, and blood vessels, reducing both quality and length of life.

The heart pumps blood through blood vessels, which carry blood to every organ. When hypertension is not properly treated, blood pressure remains high for years, and these blood vessels become stiff, narrow, and damaged. This affects blood flow to vital organs that these blood vessels supply and triggers multiple health problems.

Hypertension: Stroke And Dementia Risk

One of the most serious consequences is damage to the brain. Hypertension is the leading cause of stroke. A blood vessel in the brain may either get blocked or burst due to excessive pressure, resulting in paralysis, speech difficulty, or even death.

Repeated uncontrolled hypertension can also impair memory and thinking ability over time, increasing the risk of vascular dementia in older age. Many patients are surprised to learn that controlling blood pressure today may help preserve brain function years later.

Hypertension: The Silent Effect On Kidneys

The kidneys are another major target. High blood pressure damages the delicate blood vessels inside the kidneys, gradually reducing their ability to function.

In fact, hypertension is one of the important causes of renal failure leading to dialysis. Unfortunately, kidney damage develops silently and may remain unnoticed until advanced stages. Regular monitoring of blood pressure and kidney function is therefore essential.

Hypertension And Eyesight

The eyes, too, can suffer from uncontrolled hypertension. The tiny blood vessels of the retina may narrow, leak, or bleed, leading to blurred vision or even permanent visual loss.

Eye specialists can often detect signs of long-standing hypertension during routine retinal examination. Sometimes, the eyes provide the first warning that blood pressure has been poorly controlled for years.

Hypertension Weakens Blood Vessels

High blood pressure also weakens arteries throughout the body. It accelerates hardening of blood vessels, increases the risk of peripheral artery disease, and can contribute to aneurysms — dangerous ballooning of arteries that may rupture unexpectedly. In some patients, hypertension is linked to sexual dysfunction, sleep disturbances, and reduced exercise capacity.

Hypertension: How To Curb

The good news is that hypertension is both detectable and treatable. Lifestyle measures remain the foundation of prevention and control.

Maintaining a healthy body weight, exercising regularly, avoiding tobacco, limiting alcohol, and managing stress can significantly lower blood pressure.

Adequate sleep is equally important. However, many patients also require medicines, and these should be taken regularly even when one feels perfectly well.

Adults should check their blood pressure periodically, especially after the age of 30 or earlier if there is obesity, diabetes, or a family history of hypertension. Early diagnosis and proper treatment can prevent devastating complications later.

Hypertension is not merely a “heart problem.” It is a whole-body disease that silently injures multiple organs. Recognizing this reality is the first step toward prevention, timely treatment, and healthier living.