The COVID-19 pandemic may be over, but our immune systems are still feeling the impact. After years of battling constant viral threats, from COVID-19 to seasonal flu and other infections, our body’s defense system is exhausted. Many people continue to experience lingering inflammation, frequent illnesses, and slower recovery times. This extended state of immune stress has compromised us further to chronic illness, including autoimmune diseases and even neurodegenerative diseases such as Parkinson's. So why is our immune system still in trouble? And how do we give it its power back? Understanding immune exhaustion is the beginning of rebuilding our body's natural immunity.

A weakened immune system makes people more susceptible to disease, mental illnesses, and even sleep disorders. Now, new research indicates that immune system depletion may play an important role in the onset of Parkinson's disease, a degenerative neurologic disorder that compromises movement and cognition.

Role of Inflammation in Parkinson's Disease

Dysfunctional immune response is a leading cause of long-standing inflammation within the body, that has been found to contribute towards a multitude of conditions, including cardiovascular conditions, diabetes, depression, and neurodegenerative diseases such as Alzheimer's.

As people age, their immune system naturally becomes less effective. This deterioration, referred to as immune exhaustion, may be a key contributor to the onset and progression of Parkinson’s disease. Rebecca Wallings, a Parkinson’s Foundation Launch Award grant recipient and senior postdoctoral fellow at the University of Florida, believes that an accumulation of exhausted immune cells could be driving neurodegeneration in Parkinson’s patients.

How a Tired Immune System Might Affect Parkinson's?

Parkinson's disease is most commonly linked with the degeneration and loss of dopaminergic neurons—motor nerve cells that produce dopamine, an essential neurotransmitter for movement. While researchers have long suspected inflammation is involved in this neurodegeneration, the mechanisms are not yet well understood.

Wallings' study is on immune cell exhaustion, a process by which aging immune cells fail to control immune responses effectively. Her research indicates that instead of dampening inflammation in Parkinson's patients, attempts should be made to rejuvenate the immune system to regain its functionality.

Energy Deficiency in Immune Cells

One of the major findings of Wallings' work is the function of mitochondrial impairment in immune cell exhaustion. Mitochondria are commonly called the powerhouses of cells, as they are vital for generating energy. As mitochondria age and become inefficient, immune cells fail to function well, potentially accelerating neurodegeneration in Parkinson's disease.

Wallings has found that mutations in the LRRK2 gene, a recognized genetic risk factor for Parkinson's disease, are linked with defective mitochondrial function and immune cell exhaustion. Her current work includes testing various therapeutic approaches to restore mitochondrial function in immune cells with the potential to enhance the immune system and potentially prevent or treat Parkinson's disease.

Will Rejuvenating the Immune System Help in Treatment?

For decades, the standard practice in treating Parkinson's has been to suppress brain inflammation. Yet Wallings' work indicates that instead of slowing down immune responses, restoring the immune system could be a more successful strategy. By addressing mitochondrial impairment and immune resilience, researchers can potentially reverse or slow down Parkinson's disease.

Wallings is now looking into how to rejuvenate immune cells by fixing mitochondria. She studies immune cells from patients with Parkinson's as well as from healthy subjects and performs experiments on animal models to determine if rejuvenation of the immune system could result in improved disease outcomes.

Lifestyle Factors That May Affect Parkinson's Risk

While there is no cure for Parkinson's disease, some lifestyle adjustments may decrease the chances of developing the illness. Since neurodegenerative diseases are associated with chronic inflammation and immune dysfunction, developing habits that enhance immune function might prove helpful.

Diet: There is evidence to suggest that eating in accordance with the Mediterranean or MIND diets, both high in antioxidants, healthy fats, and anti-inflammatory foods, can encourage brain wellness and reduce Parkinson's risk.

Avoiding Dangerous Substances: Restricting alcohol and nicotine use can maintain a robust immune system and suppress inflammation.

Reducing Stress: Chronic stress weakens immune function, so methods such as meditation, exercise, and sufficient sleep can lead to improved overall well-being.

Although brain tumours are more commonly associated with older adults, they can occur at any age, including during adolescence and young adulthood. Recognising the warning signs early can help ensure timely diagnosis and treatment. Here, an expert explains the symptoms and highlights when medical attention should be sought.

What is a brain tumour?

In an interview with Health and Me, Dr Rakesh Patil, Consultant Medical Oncologist, AIMS Hospital, Dombivli, spoke about brain tumours and their rising incidence among younger Indians.

Brain tumours occur when abnormal cells grow uncontrollably within the brain or surrounding tissues. These tumours may be benign (non-cancerous) or malignant (cancerous). While brain tumours are not among the most common cancers affecting young adults, cases do occur in this age group. The exact cause of most brain tumours remains unknown. However, certain genetic conditions, a family history of brain tumours, previous exposure to radiation therapy, and rare inherited disorders may increase the risk. In many cases, affected individuals have no identifiable risk factors. Early diagnosis and appropriate treatment remain crucial for achieving the best possible outcomes.

Why are brain tumour symptoms missed?

One of the major challenges is that the early symptoms of a brain tumour can be mistaken for stress, migraines, sleep deprivation, or eye strain. Persistent headaches, especially those that worsen over time; nausea; vomiting; blurred or double vision; balance problems; unexplained seizures; weakness in an arm or leg; personality changes; memory difficulties; and problems with speech or concentration should not be ignored and warrant prompt medical evaluation.

Why are brain tumour cases rising among young Indians?

Many young adults are occupied with studies, careers, and social commitments, which may lead them to overlook symptoms or delay seeking medical attention. If left untreated, a brain tumour can affect important brain functions, including movement, speech, vision, memory, and behaviour. In some cases, it can become life-threatening.

What are the best treatment options for brain tumour?

Advances in imaging technology, neurosurgery, radiation therapy, and targeted treatments have significantly improved outcomes for many patients. Following a thorough evaluation and diagnosis, the treating physician will determine the most appropriate treatment plan based on the type, size, and location of the tumour. Some patients may also benefit from neurorehabilitation as part of their recovery.

Young adults should seek medical evaluation if they experience persistent headaches, develop neurological symptoms, or have seizures without an obvious cause. Greater awareness and timely medical attention can help improve outcomes and, in some cases, save lives.

Air pollution is one of the most impactful issues for the people of Delhi, as the city is known for having heavy air pollution, and the whole NCR faces this particular health hazard due to very high PM2.5 concentrations.

Though until now there was a public perception that the effect of this situation on babies was not massive, but that hopeful thinking has been shattered by a new study done by the All India Institute of Medical Sciences (AIIMS), Delhi.

The study by AIIMS has revealed that when fine particulate matter is found in the air, it can damage the placenta, restrict fetal growth, and increase the risk of low birth weight.

It was published in EMBO Molecular Medicine and focused on the effect of fine particulate matter in the air on pregnancy through laboratory study, animal models, and human data.

The research team observed that the presence of fine particulate matter in the air causes harm to placental function, including blood vessel formation, nutrient transport, and fetal growth.

In animal trials, the team has observed that the rats exposed to pollution have smaller litters, abnormal placentas, and babies with reduced birth weight and growth.

The research was supported by an analysis of 994 pregnancies from regions with different pollution levels. The team of AIIMS also stated that they have seen PM2.5 exposure was associated with a greater risk of low birth weight and preeclampsia.

How To Reduce Climate-related Health Risks

To reduce climate-related health risks, the experts recommend staying informed about weather conditions, remaining hydrated, limiting outdoor exposure during extreme heat, and taking precautions against mosquito bites.

People with chronic conditions such as hypertension, diabetes, heart disease, and kidney disease are advised to maintain adequate medication supplies and consult healthcare providers during periods of extreme heat.

Also Read: Meningitis Alert at UK University: Preventive Antibiotics and Vaccination Offered to Students

According to the experts, awareness and early action remain critical to protecting public health as climate change continues to reshape disease patterns around the world.

To reduce the risk of mosquito-borne diseases, people should make sure that water does not get collected in buckets, coolers, flower pots, or other containers around the home. Additional precautions include the use of mosquito repellents, sleeping under nets when necessary, and wearing clothing that covers the arms and legs.

Dr Sabine said food and water safety are particularly important after heavy rain or flooding. Proper food storage, clean drinking water, and good hygiene practices can go a long way in preventing many infections. Those with pre-existing medical conditions should also have essential medicines within easy reach during extreme weather.

Back pain was once considered a problem of ageing, heavy labour, or injury. Today, it is increasingly common among people in their 20s and early 30s. Many young Indians now walk into clinics with persistent lower back pain, neck stiffness, shooting pain down the leg, or recurrent muscle spasms—symptoms that were earlier seen more often in older adults.

Why are spine problems becoming more common?

The reasons are closely linked to the way modern life has changed. Long hours at desks, laptop use from beds or sofas, prolonged mobile phone scrolling, reduced physical activity, irregular sleep, stress, and weight gain are all placing unusual strain on the spine at a younger age.

Dr Satish Satyanarayana, Neurosurgeon, Apollo Hospitals, Bengaluru, said, "The spine is designed for movement. It depends on strong muscles, flexible joints, healthy discs, and good posture to function well. When a person sits for eight to ten hours a day, often slouched over a screen, the muscles supporting the spine become weak and tight. The discs between the vertebrae also experience uneven pressure. Over time, this can lead to chronic pain, early disc degeneration, nerve irritation, and, in some cases, slipped disc symptoms."

Posture problems among working professionals

One of the biggest contributors is poor sitting posture. Many young professionals work with rounded shoulders, forward-bent necks, and unsupported lower backs. This posture increases the load on the neck and lumbar spine. Similarly, “tech neck," caused by looking down at phones for long periods, can trigger neck pain, headaches, shoulder stiffness, and upper back discomfort.

Work-from-home habits have made the problem worse. Dining chairs, couches, beds, and low tables are not designed for long working hours. A person may feel comfortable initially, but the spine quietly absorbs the stress. By the time pain becomes persistent, the underlying muscle imbalance may already be significant.

Can lack of exercise make you prone to spine problems?

Lack of exercise is another major factor. Many young adults focus on work but neglect strength and mobility. Walking alone may not be enough if the core, hip, back, and gluteal muscles are weak. These muscle groups act like a natural brace for the spine. When they are weak, even simple activities such as bending, lifting a bag, climbing stairs, or sitting for long periods can trigger pain.

Stress also plays a role. Mental stress increases muscle tension, especially around the neck, shoulders, and lower back. Poor sleep reduces tissue recovery and increases pain sensitivity. In some people, repeated stress and inadequate rest can turn occasional discomfort into chronic pain.

Is back pain the same as posture pain?

Back pain should not always be dismissed as “posture pain." Medical evaluation is important if pain lasts more than two to three weeks, keeps returning, travels down the leg, causes numbness or weakness, worsens at night, follows an injury, or is associated with fever, unexplained weight loss, or bladder and bowel problems. These symptoms may suggest nerve compression, infection, inflammatory disease, or other serious spine conditions.

Can exercise help?

The good news is that most early spine problems are preventable and manageable. Young adults should take movement breaks every 30 to 45 minutes, set up an ergonomic workstation, keep screens at eye level, use a chair with lower back support, and avoid working from bed. Regular strengthening exercises, stretching, weight control, hydration, and good sleep are equally important.

It is better to exercise caution while undertaking heavy weightlifting, and it is certainly not advisable to do so without professional trainer supervision. It is also important to lift correctly, avoid sudden heavy gym workouts without supervision, and treat early pain seriously rather than relying repeatedly on painkillers. Pain medicines may provide temporary relief, but they do not correct the cause.

Back pain is often the body’s warning that the spine is under more stress than it can handle. The earlier young people correct their posture, improve their strength, and seek proper medical advice, the better their chances of avoiding long-term spine problems.