The COVID-19 pandemic may be over, but our immune systems are still feeling the impact. After years of battling constant viral threats, from COVID-19 to seasonal flu and other infections, our body’s defense system is exhausted. Many people continue to experience lingering inflammation, frequent illnesses, and slower recovery times. This extended state of immune stress has compromised us further to chronic illness, including autoimmune diseases and even neurodegenerative diseases such as Parkinson's. So why is our immune system still in trouble? And how do we give it its power back? Understanding immune exhaustion is the beginning of rebuilding our body's natural immunity.

A weakened immune system makes people more susceptible to disease, mental illnesses, and even sleep disorders. Now, new research indicates that immune system depletion may play an important role in the onset of Parkinson's disease, a degenerative neurologic disorder that compromises movement and cognition.

Role of Inflammation in Parkinson's Disease

Dysfunctional immune response is a leading cause of long-standing inflammation within the body, that has been found to contribute towards a multitude of conditions, including cardiovascular conditions, diabetes, depression, and neurodegenerative diseases such as Alzheimer's.

As people age, their immune system naturally becomes less effective. This deterioration, referred to as immune exhaustion, may be a key contributor to the onset and progression of Parkinson’s disease. Rebecca Wallings, a Parkinson’s Foundation Launch Award grant recipient and senior postdoctoral fellow at the University of Florida, believes that an accumulation of exhausted immune cells could be driving neurodegeneration in Parkinson’s patients.

How a Tired Immune System Might Affect Parkinson's?

Parkinson's disease is most commonly linked with the degeneration and loss of dopaminergic neurons—motor nerve cells that produce dopamine, an essential neurotransmitter for movement. While researchers have long suspected inflammation is involved in this neurodegeneration, the mechanisms are not yet well understood.

Wallings' study is on immune cell exhaustion, a process by which aging immune cells fail to control immune responses effectively. Her research indicates that instead of dampening inflammation in Parkinson's patients, attempts should be made to rejuvenate the immune system to regain its functionality.

Energy Deficiency in Immune Cells

One of the major findings of Wallings' work is the function of mitochondrial impairment in immune cell exhaustion. Mitochondria are commonly called the powerhouses of cells, as they are vital for generating energy. As mitochondria age and become inefficient, immune cells fail to function well, potentially accelerating neurodegeneration in Parkinson's disease.

Wallings has found that mutations in the LRRK2 gene, a recognized genetic risk factor for Parkinson's disease, are linked with defective mitochondrial function and immune cell exhaustion. Her current work includes testing various therapeutic approaches to restore mitochondrial function in immune cells with the potential to enhance the immune system and potentially prevent or treat Parkinson's disease.

Will Rejuvenating the Immune System Help in Treatment?

For decades, the standard practice in treating Parkinson's has been to suppress brain inflammation. Yet Wallings' work indicates that instead of slowing down immune responses, restoring the immune system could be a more successful strategy. By addressing mitochondrial impairment and immune resilience, researchers can potentially reverse or slow down Parkinson's disease.

Wallings is now looking into how to rejuvenate immune cells by fixing mitochondria. She studies immune cells from patients with Parkinson's as well as from healthy subjects and performs experiments on animal models to determine if rejuvenation of the immune system could result in improved disease outcomes.

Lifestyle Factors That May Affect Parkinson's Risk

While there is no cure for Parkinson's disease, some lifestyle adjustments may decrease the chances of developing the illness. Since neurodegenerative diseases are associated with chronic inflammation and immune dysfunction, developing habits that enhance immune function might prove helpful.

Diet: There is evidence to suggest that eating in accordance with the Mediterranean or MIND diets, both high in antioxidants, healthy fats, and anti-inflammatory foods, can encourage brain wellness and reduce Parkinson's risk.

Avoiding Dangerous Substances: Restricting alcohol and nicotine use can maintain a robust immune system and suppress inflammation.

Reducing Stress: Chronic stress weakens immune function, so methods such as meditation, exercise, and sufficient sleep can lead to improved overall well-being.

Air pollution, chemicals that interfere with hormonal health and stress due to climate may be contributing to South Asia’s growing burden of diabetes and heart disease. The Lancet study has highlighted the importance of considering other factors than diet and physical inactivity when addressing metabolic health.

A paper published in The Lancet Regional Health – Southeast Asia argues that the environmental conditions people face throughout their lives could play a key role in worsening cardiometabolic health.

The authors specifically point to a combination of exposures, from fine particulate matter in polluted air to chemicals in consumer products, that could influence how body regulates blood sugar, stores fat and maintains healthy blood vessels.

The paper, titled South Asia’s cardiometabolic burden: exposomal determinants of a health transition, was authored by Misra and Yashendra Sethi of the Department of Medicine at Subharti Medical College, Swami Vivekanand Subharti University, Meerut.

Effects Of Environmental Exposures On Metabolic Health

Also read: Delhi Air Pollution: Experts Explain Why You Feel Unusually Tired When AQI Rises

The authors use the term “exposome” to denote the range of environmental factors a person sees over their lifetime living in a particular city. These include air pollution, chemical contaminants, dietary patterns, sleep pattern and stress.

Fine particulate matter, or PM2.5, is the primary concern, according to the authors. These tiny airborne particles can seep deep into the lungs and cause inflammation that could worsen cardiovascular and respiratory illness.

The paper also highlights how prolonged exposure may contribute to metabolic dysfunction, including oxidative stress, insulin resistance and damage to the lining of blood vessels.

Chemical exposures are another area of concern. Bisphenols, phthalates and per- and polyfluoroalkyl substances (PFAS), found in various industrial and consumer applications, can interfere with hormone health. Depending on the level of exposure, these chemicals may have an effect on insulin sensitivity, appetite and fat cells in the body.

Other lifestyle will only fuel these risks. Irregular sleep, shift work and disrupted body clocks can interfere with metabolic health, while unhealthy diets featuring ultra-processed foods and stress may contribute to inflammation and other reasons that lead to chronic diseases.

The authors say that these overlapping exposures could help explain why conditions like type 2 diabetes, steatotic liver disease and cardiovascular disease are becoming alarming public health concerns in South Asia. However, the contribution of individual exposures and their combined effects requires further investigation.

South Asians Face Greater Risks Of Chronic Diseases

South Asians can develop type 2 diabetes and cardiovascular disease at younger ages and at lower body mass index levels than many Western populations. The paper places the region’s rapid economic and social transformation behind this vulnerability.

It means that generations that experienced undernutrition for centuries now live in environments influenced by urbanisation, better transport, changing diets and greater exposure to pollution. Biological tendencies towards energy storage may interact with these newer conditions, increasing metabolic risk.

Across the Asia-Pacific region, the burden of cardiometabolic disease, measured in life years after adjusting disability, rose between 1.7-fold and 3.7-fold from 1990 to 2023.

Also read: Rising AQI In Delhi-NCR: Doctors Warn Of Lung And Heart Risks As Pollution Builds

Approach For Prevention

The authors argue that advice on eating well, exercising and sleeping adequately remains important, but they cannot help when people have limited control over the air they breathe or the environmental quality.

The paper recommends monitoring environmental exposures, intervening early in life, strengthening food policies, and conducting long-term research to understand how exposures influence cardiometabolic outcomes.

The boom in GLP-1 weight loss drugs is not only affecting the obesity market but also reshaping the beauty industry. Changes in consumer behaviour among those who use GLP-1 drugs is evident as people may see differences in their appearance after drastic weight loss. This phenomenon has prompted global beauty companies to explore products for people experiencing changes in their appearance after losing weight.

French cosmetics giant L’Oréal is among the companies exploring this emerging market segment. Its CEO, Nicolas Hieronimus, said the increasing use of these medications was affecting beauty and skincare consumption, compelling the company to explore products that address concerns like sagging skin after extreme weight loss.

“The rise in their (GLP-1 drugs) use was having an impact on beauty consumption and skin care consumption in particular,” Hieronimus said during an investor call on October 22, after the company's third-quarter results came out.

The development mirrors an important shift in the beauty industry as weight loss medications like Ozempic, Wegovy and Zepbound become more widely used for weight management.

Amid the growing market for these drugs, companies are now seeing increased demand for treatments that help changes in facial volume, skin firmness and elasticity after weight loss.

However, the science behind ‘Ozempic face’ is far more complicated than the name suggests. Experts say these changes are generally associated with losing facial fat during weight loss, especially when it happens rapidly.

What is ‘Ozempic Face’?

‘Ozempic face’ is an informal term for facial changes that occur after rapid and substantial weight loss. It is marked by hollowing around the cheeks and temples and more noticeable wrinkles or sagging skin.

GLP-1 medicines, including semaglutide and tirzepatide, act on appetite regulation, helping people feel fuller for a long time and reducing their calorie intake. As a result, some people lose a substantial amount of weight over a short period.

Beauty Companies Respond to GLP-1 Boom

Apart from L’Oréal, Swiss skincare company Galderma and Brazilian cosmetics group Natura are also seeing similar demands from consumers experiencing changes in their facial skin after medicated weight loss.

L’Oréal has said that it is testing products on people using GLP-1 medications. Its SkinCeuticals range also has products intended to address concerns such as skin sagging, according to Hieronimus.

“We have products in SkinCeuticals that are made to work alongside GLP-1 drugs and address their side effects, such as skin sagging and other related issues. It is very integrated,” he said.

Galderma, in which L’Oréal holds a 20% stake, has assessed some of its existing aesthetic treatments for changes due to GLP-1 use. Its portfolio includes Sculptra, an injectable that stimulates collagen, and Restylane, a range of hyaluronic acid-based dermal fillers.

Anne-Cecile Chevrier, Galderma's global head of injectable aesthetics, described the concerns that experts are seeing among consumers. “Sagginess is a concern, loss of firmness is a concern, some hollowness can be of concern and dullness can be a concern,” she said.

Can Skincare Products Reverse ‘Ozempic Face’?

The expansion of this market does not necessarily mean that skincare products can reverse facial changes due to rapid weight loss.

The skin has several layers, and topical products act on the skin's surface. Facial fat loss happens when fat accumulated beneath the skin melts off. Skincare products cannot simply replace this process.

Dr Graeme Glass, a plastic and craniofacial surgeon and aesthetic director at British beauty brand LYMA, explained the limitations of topical treatments. “They can't reposition the deep fat pads of the face. There is a limit to what these things can do,” he said.

Moisturisers and other products may help improve hydration, texture and the appearance of fine lines. But these benefits should not be confused with correcting sagging skin.

Treatments like fillers and collagen injectables may address these concerns directly, but they involve different risks, costs and clinical considerations.

Avani Sinha, MD, and FACE endocrinologist and program director of the Northwell Health Division of Endocrinology, Diabetes and Metabolism fellowship told Women's Health Magazine that it is important to take care of nutrition and muscle-building to "fill up spaces where you are losing that skin laxity".

“We are what we eat, we are what we do,” she said, stating that protein intake is especially important on a GLP-1. She suggested aiming 0.8 to 1.8 grams per kilogram of body weight.

Sinha also recommended staying hydrated along with strength training to build muscle. “You build up that muscle, you're going to fill up those spaces where you're losing that skin laxity,” she said.

US journalist Norah O’Donnell recently spoke about the importance of early skin cancer detection a decade after being diagnosed with melanoma, the most dangerous form of skin cancer.

She said her experience changed her outlook towards sun protection. She also shared advice related to skin cancer from her dermatologist, Dr Elizabeth Hale.

According to CBS News, O’Donnell recalled that it was during a routine dermatology appointment when Hale noticed two concerning spots on her back.

A biopsy confirmed melanoma, but the cancer was detected early and removed before it could spread.

O’Donnell said she now seeks shade wherever she can find, wears UV-protective clothing and regularly reapplies broad-spectrum sunscreen when spending time outdoors. She also reflected on her past exposure to sunburns and tanning salons.

Detecting Melanoma Early

Melanoma develops in the cells that produce melanin, the pigment responsible for skin colour. Although it accounts for a smaller proportion of skin cancer cases, it is responsible for an alarming share of skin cancer deaths.

Hale emphasised that early detection can make a considerable difference. “Even though it only accounts for 5% of new cases of skin cancer, it’s responsible for more than 75% of skin cancer-related deaths,” she said.

She also spoke about the importance of getting suspicious spots examined rather than waiting for them to become more noticeable and serious.

“There have been major advances in melanoma treatment, but it’s still really best to get your skin checked because when melanoma is caught early it has greater than a 99% five-year survival. But once it spreads, that survival rate goes down precipitously,” Hale said.

Also read: Jeana Keough’s Cancer Battle: Why The ‘RHOC’ Star Is Struggling To Recover After Tongue Cancer Treatment

Tanning Beds And Sunburns Increase Melanoma Risk

Speaking about skin cancer risks related to tanning beds and sunburns, Hale said melanoma cases have been increasing among women in their 20s and 30s.

“It is directly related to exposure to tanning beds and to sunburns,” she said.

According to the Skin Cancer Foundation, using tanning beds before 35 could increase melanoma risk by 75%.

Hale also warned against the growing trend of deliberately seeking a tan through prolonged, unprotected sun exposure.

“There really is no such thing as … a safe, healthy tan,” she said.

A tan is not simply a cosmetic appeal. As Hale explained, it denotes “DNA damage” that may contribute to cancer later in life.

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What Does Her Dermatologist Recommend?

Hale recommends regular skin examinations to nab suspicious skin changes early. She advises people to discuss their individual cancer screening needs with a dermatologist, especially if they have a family history of skin cancer.

Sun protection is another essential part of prevention. Hale recommends using a broad-spectrum sunscreen with SPF 30 or higher and reapplying it every two hours when spending extended periods outdoors.

Her advice on choosing sunscreen is straightforward: “the best sunscreen is the one you’ll actually use”.

Non-Negotiable Sunscreen Ritual

As per the Johns Hopkins Medicine, wearing sunscreen is the easiest and the best ways to protect your skin's appearance and health at any age. It recommends to use it regularly to prevent sunburn, skin cancer, and premature aging.

While everyone needs sun exposure to produce vitamin D, unprotected exposure to the sun's UV rays can cause damage to the eyes, skin, and the immune system.

To protect, apply 1 ounce of sunscreen throughout your body. To protect your face and neck, you will need about half a teaspoon of sunscreen.

Experts also believe that as long as the sunscreen is at least SPF 30 and is water-resistant, it does not matter what order you apply your skin care products. While some people find it is easiest to work with bare skin, some do it at the end.

Protective clothing and seeking shade can provide additional protection, especially during prolonged outdoor activities.