The COVID-19 pandemic may be over, but our immune systems are still feeling the impact. After years of battling constant viral threats, from COVID-19 to seasonal flu and other infections, our body’s defense system is exhausted. Many people continue to experience lingering inflammation, frequent illnesses, and slower recovery times. This extended state of immune stress has compromised us further to chronic illness, including autoimmune diseases and even neurodegenerative diseases such as Parkinson's. So why is our immune system still in trouble? And how do we give it its power back? Understanding immune exhaustion is the beginning of rebuilding our body's natural immunity.

A weakened immune system makes people more susceptible to disease, mental illnesses, and even sleep disorders. Now, new research indicates that immune system depletion may play an important role in the onset of Parkinson's disease, a degenerative neurologic disorder that compromises movement and cognition.

Role of Inflammation in Parkinson's Disease

Dysfunctional immune response is a leading cause of long-standing inflammation within the body, that has been found to contribute towards a multitude of conditions, including cardiovascular conditions, diabetes, depression, and neurodegenerative diseases such as Alzheimer's.

As people age, their immune system naturally becomes less effective. This deterioration, referred to as immune exhaustion, may be a key contributor to the onset and progression of Parkinson’s disease. Rebecca Wallings, a Parkinson’s Foundation Launch Award grant recipient and senior postdoctoral fellow at the University of Florida, believes that an accumulation of exhausted immune cells could be driving neurodegeneration in Parkinson’s patients.

How a Tired Immune System Might Affect Parkinson's?

Parkinson's disease is most commonly linked with the degeneration and loss of dopaminergic neurons—motor nerve cells that produce dopamine, an essential neurotransmitter for movement. While researchers have long suspected inflammation is involved in this neurodegeneration, the mechanisms are not yet well understood.

Wallings' study is on immune cell exhaustion, a process by which aging immune cells fail to control immune responses effectively. Her research indicates that instead of dampening inflammation in Parkinson's patients, attempts should be made to rejuvenate the immune system to regain its functionality.

Energy Deficiency in Immune Cells

One of the major findings of Wallings' work is the function of mitochondrial impairment in immune cell exhaustion. Mitochondria are commonly called the powerhouses of cells, as they are vital for generating energy. As mitochondria age and become inefficient, immune cells fail to function well, potentially accelerating neurodegeneration in Parkinson's disease.

Wallings has found that mutations in the LRRK2 gene, a recognized genetic risk factor for Parkinson's disease, are linked with defective mitochondrial function and immune cell exhaustion. Her current work includes testing various therapeutic approaches to restore mitochondrial function in immune cells with the potential to enhance the immune system and potentially prevent or treat Parkinson's disease.

Will Rejuvenating the Immune System Help in Treatment?

For decades, the standard practice in treating Parkinson's has been to suppress brain inflammation. Yet Wallings' work indicates that instead of slowing down immune responses, restoring the immune system could be a more successful strategy. By addressing mitochondrial impairment and immune resilience, researchers can potentially reverse or slow down Parkinson's disease.

Wallings is now looking into how to rejuvenate immune cells by fixing mitochondria. She studies immune cells from patients with Parkinson's as well as from healthy subjects and performs experiments on animal models to determine if rejuvenation of the immune system could result in improved disease outcomes.

Lifestyle Factors That May Affect Parkinson's Risk

While there is no cure for Parkinson's disease, some lifestyle adjustments may decrease the chances of developing the illness. Since neurodegenerative diseases are associated with chronic inflammation and immune dysfunction, developing habits that enhance immune function might prove helpful.

Diet: There is evidence to suggest that eating in accordance with the Mediterranean or MIND diets, both high in antioxidants, healthy fats, and anti-inflammatory foods, can encourage brain wellness and reduce Parkinson's risk.

Avoiding Dangerous Substances: Restricting alcohol and nicotine use can maintain a robust immune system and suppress inflammation.

Reducing Stress: Chronic stress weakens immune function, so methods such as meditation, exercise, and sufficient sleep can lead to improved overall well-being.

Many couples who consult a fertility specialist are advised to undergo Assisted Reproductive Techniques, such as in vitro fertilisation (IVF). However, there are many myths linked to IVF regarding pain and injections. According to the experts, the procedure is more manageable and less painful than commonly believed. This article helps debunk myths surrounding IVF injections.

Dr Sulbha Arora, Clinical Director & Fertility Specialist, Nova IVF Fertility, Andheri, Mumbai, and Dr Anuranjita Pallavi, Consultant – Fertility & IVF Specialist, Motherhood Fertility & IVF, Kharghar, Navi Mumbai, collectively listed some of the most common myths associated with the stigma surrounding IVF – whether it is painful, complicated, or even worth the financial investment.

Currently, many are opting for IVF, a process where eggs are collected from a woman’s ovaries and fertilised with sperm in a laboratory. The embryo is then transferred into the uterus for conception. Couples may consider IVF for several reasons, such as blocked fallopian tubes, low sperm count, hormonal issues, age-related fertility decline, or unexplained infertility. For many, IVF becomes a go-to option, offering hope and a chance to start a family. However, despite its growing success, IVF is still surrounded by fear, especially when it comes to injections and pain. Social media, hearsay, and lack of awareness often make the process seem more difficult and can prevent couples from exploring it.

The IVF journey is different for each woman. IVF does involve medical procedures, but it is not as painful or overwhelming as people believe. One of the biggest concerns around IVF is the use of injections. These injections are given to stimulate the ovaries to produce multiple eggs. While the idea of daily injections can be intimidating, most are administered using very fine needles and are relatively painless. Patients may feel slight discomfort, similar to a small prick, but it is usually manageable and short-lived.

Common IVF Myths Debunked

1. Myth: IVF injections cause extreme pain—IVF injections cause minimal discomfort, and women should not worry. Most patients experience mild and easy-to-manage pain, especially with guidance from an expert.
2. Myth: IVF is a very complicated and stressful process. While IVF consists of multiple steps, doctors guide patients throughout the journey. With proper counselling and support, the process becomes much smoother and less stressful for women.
3. Myth: IVF guarantees pregnancy in one cycle - IVF increases the chances of pregnancy but may not be successful on the first attempt. Success depends on factors such as age, health, and underlying fertility conditions. So, do not get disheartened if the first cycle fails. The first cycle provides a lot of information, and certain steps can be taken, along with changes made to the next attempt, in order to improve the chances of success.

Understanding the facts and debunking common myths can help reduce anxiety and build confidence in couples.

Couples often hesitate to opt for IVF due to the fear of injections and the assumption that the process will be extremely painful or emotionally exhausting. However, with advancements in fertility care today, IVF has become far more patient-friendly, safe, and comfortable than most people imagine. One of the biggest myths is that IVF injections are administered painfully multiple times throughout the day. In reality, most injections are scheduled and simple to administer, and many couples are even taught how to take them comfortably at home.

Another important aspect people often overlook is that IVF treatment today is highly personalised.

While some women may experience temporary bloating, mild cramps, mood changes, or fatigue due to hormonal medications, these symptoms are usually manageable and closely monitored by the facility team. Most women can continue their daily routine during treatment without any major challenges. Equally important are support, counselling, and clear communication with the fertility team, which help reduce anxiety and build confidence. It is necessary to understand that IVF is a step-by-step guided process designed to give couples hope and a better chance at parenthood. Hence, make sure to consult an expert, clear all doubts, and initiate IVF treatment as soon as possible to achieve the dream of pregnancy.

Everyone knows that when cancer is detected early, cure rates are far superior, side effects are much less, and treatment expenses are also less.

Diagnosis of cancer depends upon carrying out various tests and then their analysis to reach a conclusion.

How AI Supports Cancer Diagnosis

These tests are radiological, like Chest X-ray, CT scans, MRI, Mammography, etc., and in histopathology, analysis of tissue, be it a small biopsy, large specimen handling, or Frozen Section. AI is empowered with large data to suggest and analyze minute patterns that are difficult for a human mind to comprehend, supported by machine learning.

With the use of AI in the analysis of radiological data, it points out suspicious changes (data is fed into its memory), but they are not very clearly visible to the human eye. Hence, it alerts the radiologist to have a close look at that and enhances accuracy and reduces the chances. It is the radiologist who takes the final call because it has to be correlated with the patient’s clinical findings and other information from other investigations of the patient.

Early detection of breast cancer has received a big boost from the integration of AI in the analysis of mammography data. Similar applications are also used by pathologists when they are examining the tissues because the final diagnosis of cancer can be obtained on histopathology only.

Challenges In The Use Of AI

Use of AI is not without challenges: knowledge of proper tools and applications is critical. Results can not be relied upon blindly, and an expert is very critical of their analysis. Sometimes there may be an improper result that needs to be filtered out.

It's time to accept that AI is present and not the future, and we need to learn, adapt, and use it to the benefit of mankind. India is making great strides in AI, and many startups have also come up that are doing a great job.

The real strength of AI in the care of cancer mainly lies in its ability to support the doctors in making faster, sharper, and more well-informed decisions. It can also reduce delay in diagnostics, improve efficiency of screening, and help in detecting cancers at a stage where outcomes of treatment are much better.

Amid rising summer temperatures, along with pollution, eye specialists today warned that the heat and dust can add stress on the eyes, leading to dryness, allergies, infections, and irritation.

Delhi witnessed its first official heatwave day of the month on Tuesday, as scorching sunshine and dry winds pushed temperatures beyond 45°C across several parts of the city.

The India Meteorological Department (IMD) warned that conditions are likely to worsen over the coming days, with temperatures expected to rise to nearly 46°C on May 20.

The weather department has also issued an orange alert for Delhi until May 25, cautioning residents about prolonged heatwaves and excessive heat conditions expected over six consecutive days.

Allergies, Dryness, and Infections Common In Summer

Speaking to HealthandMe, Dr. Bhavatharini M, Senior Consultant Ophthalmologist at Dr. Agarwal's Eye Hospital, said that summer conditions can significantly impact eye health.

“Summer places added stress on the eyes, particularly in cities like New Delhi where heat, dust, and pollution are significant factors,” she said.

Dr. Bhavatharini explained that common concerns during the season include dryness caused by increased tear evaporation while

• watching screens,
• allergies triggered by environmental irritants,
• UV-related damage,
• infections linked to swimming in poorly maintained pools.

Dr. Kalpana R, Senior Consultant, Ophthalmology at SIMS Hospital, also warned of problems that affect the eyes during this season, such as

• allergies,
• dryness,
• seasonal infections,
• viral and bacterial infections,
• swimming pool infections,
• migraine headaches.

She stressed the importance of maintaining proper hydration and following a balanced, nutritious diet to support eye health during the hotter months.

How To Prevent Eye Health In Scorching Summers

Dr. Bhavatharini advised people to take simple preventive measures, such as wearing UV-protective sunglasses, staying well-hydrated, avoiding rubbing their eyes, and using protective goggles while swimming.

“Persistent redness, irritation, or blurred vision should not be ignored and warrants timely evaluation by your eye specialist,” she added.

Dr. Kalpana further recommended wearing protective eyewear outdoors to shield the eyes from harmful UV rays and glare.

People travelling on bikes should wear helmets with visors to reduce exposure to dust and pollution, while swimmers should use swimming goggles to prevent infections and injuries associated with pool water.

For allergies, she advised people not to rub their eyes even if they experience itching.

“Just as a home remedy, you can use an ice pack over the closed eyelids or splash cold water over the closed eyelids to get some immediate relief,” she told HealthandMe.

Avoid Self-Medication

The experts also warned against self-medication in case of eye infections.

“And for viral infections and bacterial infections, if you feel that you get a sticky discharge and redness, you must immediately go to an ophthalmologist and get it treated. Never use over-the-counter medicines for any of your infections,” Dr. Kalpana said.

She added that people with common cold symptoms should wear masks and avoid touching commonly used surfaces if they have signs of an eye infection, as infections can spread through secretions.