The COVID-19 pandemic may be over, but our immune systems are still feeling the impact. After years of battling constant viral threats, from COVID-19 to seasonal flu and other infections, our body’s defense system is exhausted. Many people continue to experience lingering inflammation, frequent illnesses, and slower recovery times. This extended state of immune stress has compromised us further to chronic illness, including autoimmune diseases and even neurodegenerative diseases such as Parkinson's. So why is our immune system still in trouble? And how do we give it its power back? Understanding immune exhaustion is the beginning of rebuilding our body's natural immunity.

A weakened immune system makes people more susceptible to disease, mental illnesses, and even sleep disorders. Now, new research indicates that immune system depletion may play an important role in the onset of Parkinson's disease, a degenerative neurologic disorder that compromises movement and cognition.

Role of Inflammation in Parkinson's Disease

Dysfunctional immune response is a leading cause of long-standing inflammation within the body, that has been found to contribute towards a multitude of conditions, including cardiovascular conditions, diabetes, depression, and neurodegenerative diseases such as Alzheimer's.

As people age, their immune system naturally becomes less effective. This deterioration, referred to as immune exhaustion, may be a key contributor to the onset and progression of Parkinson’s disease. Rebecca Wallings, a Parkinson’s Foundation Launch Award grant recipient and senior postdoctoral fellow at the University of Florida, believes that an accumulation of exhausted immune cells could be driving neurodegeneration in Parkinson’s patients.

How a Tired Immune System Might Affect Parkinson's?

Parkinson's disease is most commonly linked with the degeneration and loss of dopaminergic neurons—motor nerve cells that produce dopamine, an essential neurotransmitter for movement. While researchers have long suspected inflammation is involved in this neurodegeneration, the mechanisms are not yet well understood.

Wallings' study is on immune cell exhaustion, a process by which aging immune cells fail to control immune responses effectively. Her research indicates that instead of dampening inflammation in Parkinson's patients, attempts should be made to rejuvenate the immune system to regain its functionality.

Energy Deficiency in Immune Cells

One of the major findings of Wallings' work is the function of mitochondrial impairment in immune cell exhaustion. Mitochondria are commonly called the powerhouses of cells, as they are vital for generating energy. As mitochondria age and become inefficient, immune cells fail to function well, potentially accelerating neurodegeneration in Parkinson's disease.

Wallings has found that mutations in the LRRK2 gene, a recognized genetic risk factor for Parkinson's disease, are linked with defective mitochondrial function and immune cell exhaustion. Her current work includes testing various therapeutic approaches to restore mitochondrial function in immune cells with the potential to enhance the immune system and potentially prevent or treat Parkinson's disease.

Will Rejuvenating the Immune System Help in Treatment?

For decades, the standard practice in treating Parkinson's has been to suppress brain inflammation. Yet Wallings' work indicates that instead of slowing down immune responses, restoring the immune system could be a more successful strategy. By addressing mitochondrial impairment and immune resilience, researchers can potentially reverse or slow down Parkinson's disease.

Wallings is now looking into how to rejuvenate immune cells by fixing mitochondria. She studies immune cells from patients with Parkinson's as well as from healthy subjects and performs experiments on animal models to determine if rejuvenation of the immune system could result in improved disease outcomes.

Lifestyle Factors That May Affect Parkinson's Risk

While there is no cure for Parkinson's disease, some lifestyle adjustments may decrease the chances of developing the illness. Since neurodegenerative diseases are associated with chronic inflammation and immune dysfunction, developing habits that enhance immune function might prove helpful.

Diet: There is evidence to suggest that eating in accordance with the Mediterranean or MIND diets, both high in antioxidants, healthy fats, and anti-inflammatory foods, can encourage brain wellness and reduce Parkinson's risk.

Avoiding Dangerous Substances: Restricting alcohol and nicotine use can maintain a robust immune system and suppress inflammation.

Reducing Stress: Chronic stress weakens immune function, so methods such as meditation, exercise, and sufficient sleep can lead to improved overall well-being.

Work, school, competition—stress appears to be inevitable these days. Across age groups, many are dealing with it in some form or the other, but unfortunately stress never stops at just headaches or fatigue. It has direct effects on an individual's health through causing disease (such as cardiovascular problems); it also has indirect effects on health by negatively influencing other health behaviors such as physical activity and sleep. It is also vital to note that stress is one of the leading health risks for people in the work environment. Healthcare professionals are advised to consider both major stressors and those that occur regularly. Further discussion about stress reduction strategies is provided.

Dr Anshuman Kaushal, Director of Robotic GI, Minimal Access & Bariatric Surgery at CK Birla Hospital, Gurugram, in an interview with Health and Me, spoke about the long-term effects of chronic stress and why it can be termed a lifestyle disorder.

Mechanisms of Chronic Stress

Exposure to certain stressors activates the HPA axis, and as a result, adrenaline and cortisol are released. While these hormones play a crucial role in survival during emergencies, they can result in serious health problems when continuously present in the body. Some of the most common consequences of stress are low immunity, insulin resistance, or inflammation. It can over time result in hypertension or heart disease.

Lifestyle as the Main Cause

With growing rates of urbanisation, competitive workplaces, financial issues, and the development of technology leading to a permanently accessible Internet, the boundaries between working time and time for rest have been blurred entirely. Moreover, an insufficient amount of sleep, poor sleeping habits, and a sedentary lifestyle cause stress as well. The young generation in India has become victims of stress-related disorders the most.

Identification of the Symptoms

One of the major challenges when identifying chronic stress cases lies in the subtlety of the condition. The list of symptoms includes constant fatigue, irritability, concentration issues, headaches, tight muscles, and insomnia. Other symptoms of the condition include gastrointestinal disorders such as acid reflux, bloating, and loss of appetite that are hardly ever associated with stress.

Long-term effects of stress

Chronic stress may appear harmless, but the truth is quite contrary. When an individual is stressed for too long without controlling it, it may result in anxiety disorders like depression. Physiological side effects of stress are:

1. Poor immunity
2. Inflammation
3. Obesity
4. Diabetes
5. Weakened memory
6. Mood swings

What makes chronic stress a lifestyle disease?

While most lifestyle disorders are caused by environmental factors and behavioural alterations, it can be termed a lifestyle disease. These disorders are progressive and require constant intervention in the form of medication or meditation.

Managing chronic stress

Doctors say that it takes a comprehensive strategy to reduce cortisol levels in the body and uplift mood. For instance, workouts like weight training or yoga are known to increase levels of happy hormones, thereby reducing stress. Breathing exercises and meditation, too, have a positive impact on mental health. Experts recommend combining them with nutrition, proper sleep, and socialising.

Early diagnosis matters

Chronic stress is not just a symptom of modern life but also a key health problem. Recognising it as a health issue and addressing it helps combat the long-term consequences well in time. And with continued changes in lifestyle habits and patterns, a lifestyle disease like chronic stress can also be brought under control for the better.

Asha Bhosle, India's veteran singer, died of cardiac arrest on Sunday. On Saturday evening, the 92-year-old was admitted to Mumbai's Breach Candy Hospital. Initially, she was admitted due to a chest infection but was later moved to the ICU the same night. The news of her hospitalisation was confirmed by her singer granddaughter Zanai Bhosle, citing 'extreme exhaustion and chest infection'.

"My grandmother, Asha Bhosle, due to extreme exhaustion and suffering a chest infection, has been admitted to hospital and we request you to value our privacy. Treatment is ongoing and hopefully everything will be well and we shall update you positively," Zanai wrote.

What is cardiac arrest?

A cardiac arrest is a medical emergency that requires immediate attention. It is characterised by a sudden halt in heart function – it stops beating and blood circulation to the brain and organs is consequently cut off. It is characterised by unresponsiveness, sudden collapse, and lack of breathing. As opposed to a heart attack, a cardiac arrest is an electrical failure caused by conditions like arrhythmia. The symptoms can include palpitations, dizziness, shortness of breath, and sudden collapse. For treatment, or as a life-saving measure, CPR must be performed.

What is CPR?

Cardiopulmonary Resuscitation (CPR) is an emergency procedure for patients who suffer a cardiac arrest. It combines chest compressions and rescue breathing to ensure oxygen flow to the organs. It is an effort to resuscitate a patient, and performing it immediately can double or even triple the chances of survival.

How to perform CPR?

To perform CPR on an adult, follow the given steps:

1. Begin by checking if the collapsed patient is responsive
2. Check if the patient is breathing or not, even if he or she is only gasping
3. Lay the patient on the ground with their back on a firm, flat surface
4. Place the heel of one of your hands on the centre of the chest and place the other hand on top of it
5. Start delivering chest compressions – hard and fast
6. Push at a rate of 100 to 120 compressions per minute and allow the chest to return to normal
7. You may combine 30 compressions with two rescue breaths until an ambulance arrives, or till the patient wakes up

Simply performing this can double the odds of survival, which is why CPR training is a must for all. However, doctors say that if not trained in CPR, then only perform compressions.

The prevalence of diseases and disorders in the gastrointestinal tract has increased within the last decade due to significant lifestyle modifications. Patients suffering from gastroenterological diseases exhibit high levels of depression, stress, anxiety, and dysfunction in the central nervous system. The name "functional gastrointestinal disorder" refers to numerous diseases manifesting symptoms related to GI problems (for example, pain in the abdomen, difficulty swallowing, indigestion, diarrhea, constipation, and bloating) but lacking detectable physical anomalies during standard diagnostic tests. There are 20 different diseases categorized as FGID in children. FGIDs have an extremely high frequency. Almost every other individual has met the criteria for FGIDs.

Dr. Anukalp Prakash, Director, Gastroenterology, CK Birla Hospital, Gurugram, in an interview with Health and Me, spoke about the rising incidence of

Prevalence Trends of Functional Gastrointestinal Disorders in India

Functional Gastrointestinal Disorders (FGIDs) occur frequently among adolescents, causing significant morbidity. Nevertheless, the actual prevalence rate is not well-defined yet. FGIDs are commonly encountered in school- and college-going adolescents, with most FGIDs being functional abdominal pain disorders.

Lifestyle Issues that Influence the Health of the Gastrointestinal System in Adolescents

1. Diet: Overconsumption of fast foods, junk foods, and sweet drinks leads to disturbances in the gut flora. Frequent consumption of oil-containing foods and spices raises the risk of heartburn and inflammation. Irregular meal times lead to indigestion.
2. Sedentary Lifestyle: Increased periods spent sitting because of online classes and remote working have adverse effects on intestinal motility. Inadequate physical activity leads to obesity and insulin resistance—the main causes of liver diseases.
3. Stress and Sleep Disorders: Educational and occupational stress affect brain-gut interactions. Stress causes irritable bowel syndrome. Sleep deprivation has a negative impact on liver function.
4. Substance Abuse: College alcohol abuse causes liver diseases like fatty liver and hepatitis. Cigarettes and energy drinks are detrimental to the GI tract and the liver.

Youth Lifestyles and Liver Disorders

1. Non-Alcoholic Fatty Liver Disease (NAFLD): NAFLD was uncommon among the youth previously but is becoming more prevalent nowadays. This is highly associated with obesity, insulin resistance, and bad dietary habits. The condition has no symptoms and develops gradually from benign fatty liver to cirrhosis.
2. Liver Injuries due to Alcohol Abuse: Binge drinking is common nowadays among the youth, especially among university students and city dwellers. Consumption of large amounts of alcohol in short periods of time leads to fatty liver or hepatitis. Persistent abuse leads to cirrhosis that develops earlier than usual.
3. Metabolic Disorders among Youths: These include several disorders such as obesity, diabetes, and high blood pressure due to lifestyle changes. These conditions have increased in prevalence in India as well as across the globe and result in NAFLD and heart ailments.

Management and Prevention Techniques

1. Dietary Modifications: Intake of whole grains, fruits, and vegetables along with drinking enough water should be suggested. Refined foods, beverages, and fast food should be reduced.
2. Daily Exercise: Doing moderate exercise for at least 30 – 45 minutes daily is suggested. Spending less time on the screens and opting for more exercise is recommended.
3. Stress Reduction and Sleep Patterns: Yoga and meditation practices enable better connection between the brain and intestines. Eight hours of sleep each night contribute to better regeneration of the liver.
4. Avoidance of Risky Behavior: Not consuming any alcohol, smoking cigarettes, or drinking energy drinks. Instead, recommending stress-reducing physical activities is suggested.
5. Frequent Screening for Illnesses: Liver screenings should be performed for young people who are at risk of health issues.