The COVID-19 pandemic may be over, but our immune systems are still feeling the impact. After years of battling constant viral threats, from COVID-19 to seasonal flu and other infections, our body’s defense system is exhausted. Many people continue to experience lingering inflammation, frequent illnesses, and slower recovery times. This extended state of immune stress has compromised us further to chronic illness, including autoimmune diseases and even neurodegenerative diseases such as Parkinson's. So why is our immune system still in trouble? And how do we give it its power back? Understanding immune exhaustion is the beginning of rebuilding our body's natural immunity.

A weakened immune system makes people more susceptible to disease, mental illnesses, and even sleep disorders. Now, new research indicates that immune system depletion may play an important role in the onset of Parkinson's disease, a degenerative neurologic disorder that compromises movement and cognition.

Role of Inflammation in Parkinson's Disease

Dysfunctional immune response is a leading cause of long-standing inflammation within the body, that has been found to contribute towards a multitude of conditions, including cardiovascular conditions, diabetes, depression, and neurodegenerative diseases such as Alzheimer's.

As people age, their immune system naturally becomes less effective. This deterioration, referred to as immune exhaustion, may be a key contributor to the onset and progression of Parkinson’s disease. Rebecca Wallings, a Parkinson’s Foundation Launch Award grant recipient and senior postdoctoral fellow at the University of Florida, believes that an accumulation of exhausted immune cells could be driving neurodegeneration in Parkinson’s patients.

How a Tired Immune System Might Affect Parkinson's?

Parkinson's disease is most commonly linked with the degeneration and loss of dopaminergic neurons—motor nerve cells that produce dopamine, an essential neurotransmitter for movement. While researchers have long suspected inflammation is involved in this neurodegeneration, the mechanisms are not yet well understood.

Wallings' study is on immune cell exhaustion, a process by which aging immune cells fail to control immune responses effectively. Her research indicates that instead of dampening inflammation in Parkinson's patients, attempts should be made to rejuvenate the immune system to regain its functionality.

Energy Deficiency in Immune Cells

One of the major findings of Wallings' work is the function of mitochondrial impairment in immune cell exhaustion. Mitochondria are commonly called the powerhouses of cells, as they are vital for generating energy. As mitochondria age and become inefficient, immune cells fail to function well, potentially accelerating neurodegeneration in Parkinson's disease.

Wallings has found that mutations in the LRRK2 gene, a recognized genetic risk factor for Parkinson's disease, are linked with defective mitochondrial function and immune cell exhaustion. Her current work includes testing various therapeutic approaches to restore mitochondrial function in immune cells with the potential to enhance the immune system and potentially prevent or treat Parkinson's disease.

Will Rejuvenating the Immune System Help in Treatment?

For decades, the standard practice in treating Parkinson's has been to suppress brain inflammation. Yet Wallings' work indicates that instead of slowing down immune responses, restoring the immune system could be a more successful strategy. By addressing mitochondrial impairment and immune resilience, researchers can potentially reverse or slow down Parkinson's disease.

Wallings is now looking into how to rejuvenate immune cells by fixing mitochondria. She studies immune cells from patients with Parkinson's as well as from healthy subjects and performs experiments on animal models to determine if rejuvenation of the immune system could result in improved disease outcomes.

Lifestyle Factors That May Affect Parkinson's Risk

While there is no cure for Parkinson's disease, some lifestyle adjustments may decrease the chances of developing the illness. Since neurodegenerative diseases are associated with chronic inflammation and immune dysfunction, developing habits that enhance immune function might prove helpful.

Diet: There is evidence to suggest that eating in accordance with the Mediterranean or MIND diets, both high in antioxidants, healthy fats, and anti-inflammatory foods, can encourage brain wellness and reduce Parkinson's risk.

Avoiding Dangerous Substances: Restricting alcohol and nicotine use can maintain a robust immune system and suppress inflammation.

Reducing Stress: Chronic stress weakens immune function, so methods such as meditation, exercise, and sufficient sleep can lead to improved overall well-being.

Your weight not only affects your heart health but also your brain health. A recent study published in the Journal of Clinical Endocrinology & Metabolism has revealed a powerful connection between your body weight, heart and brain.

After studying over 500,000 people, scientists discovered that having a high Body Mass Index (BMI) can nearly double your chances of developing brain-related illnesses later in life, which confirms that being overweight and having high blood pressure are not just general health concerns, they are direct causes of dementia.

How Does Your Weight Affect Brain Health?

The study focused heavily on vascular dementia, a specific type of memory loss that occurs when the brain is damaged because of a lack of blood flow.

Think of your blood vessels like a system of pipes. If those pipes are narrowed or blocked due to weight-related issues, the "engine" (your brain) doesn't get the fuel it needs. Over time, this lack of oxygen and nutrients leads to permanent brain damage and the loss of memory and thinking skills.

Researchers found that high blood pressure, often caused by carrying extra weight, is the main "middleman" in this process. Blood pressure is measured with two numbers, and both play a part in brain health:

Systolic

This is the pressure when your heart beats. It accounts for about 18 percent of the link between obesity and dementia.

Diastolic

This is the pressure when your heart rests between beats. It accounts for about 25 percent of the link. When these numbers stay high, they constantly "batter" the delicate vessels in the brain, causing them to weaken or clog.

How Weight Affects the Brain

Beyond just blood flow, a high BMI impacts the brain in several other ways:

Increased Inflammation

Obesity often causes the body to be in a constant state of "alarm" or inflammation. This can irritate the immune system and eventually damage brain cells.

Metabolism Issues

When the body struggles to process energy and food properly, it changes how the brain uses energy, which can lead to cognitive decline.

Heart Strain

A heart that has to work harder to pump blood through a larger body eventually becomes less efficient at sending blood all the way up to the brain. Your heart essentially has to do twice as much work as it would at a lower weight.

Can Preventing Obesity Help Dementia?

The most encouraging takeaway from this study is that dementia isn't always a matter of bad luck or "old age." Researchers call this an unexploited opportunity.

By managing your weight and blood pressure early in life, through a healthy diet, consistent exercise, and good sleep, you are essentially "dementia-proofing" your brain. The researchers suggested that intervening early, possibly even with weight-loss medications before symptoms start, could be a key strategy for protecting brain health in the future.

How Much Does Obesity Affect Worldwide?

According to the World Health Organization, one in eight people in the world are living with obesity. In 2022, about 2.5 billion adults were overweight. Causes of it vary, from things like diseases or chronic conditions, to the kind of food that is available to consume.

Heart attacks need immediate intervention and Dr. Balbir revealed one medicine that can save a life when this happens: Aspirin. In an interview with HealthandMe, Dr. Singh revealed that one does not need fancy equipment to help a person having a heart attack.

“If the history of the family history or cholesterol or diabetic. This patient is at risk, so what is the medicine if you get such a symptom? Aspirin.”

What Medicine Can Help a Heart Attack?

Dr. Singh points out that if you or someone near you begins to experience symptoms of a heart attack, such as heavy chest pain, pressure, or unexplained sweating, taking a dissolvable aspirin immediately can be a lifesaver.

By dissolving a tablet (like Dispirin) in a glass of water and drinking it, the medicine dissolves into the bloodstream much more quickly than simply ingesting it.

Aspirin works by thinning the blood and preventing further clotting in the arteries, which can stop a heart attack from getting worse before medical professionals arrive.

Other Preventative Measures To Take For Heart Attack

Before medical professionals arrive, performing CPR can also help save a person's life; however, one must know the right way to do CPR.

While speaking to HealthandMe, Dr Singh mentioned a viral video where a person collapses and someone attempts to give them CPR while they are still sitting in a chair, notng that this was 'a dangerous mistake' and people should steer clear away from such false videos.

He explained that you cannot perform CPR on someone who is sitting up as the body must be positioned correctly for the heart and lungs to receive the benefit of the chest compressions.

Without the proper technique, blood will not reach the brain and your efforts will not help the patient. Understanding the proper sequence of events is the difference between a failed attempt and a saved life.

Step 1: The Importance of Positioning

If someone collapses, immediately place them flat on their back on a hard floor. You need the ground's resistance to pump the heart manually. In this position, the heart is "sandwiched" between the rib cage and spine. On a soft bed, your presses will fail to squeeze the heart effectively.

Step 2: Focus on the Heart First

Dr. Singh emphasizes that restarting the heart is the absolute priority. Place both hands in the center of the chest and use your body weight to press firmly. By pushing the rib cage toward the spine, you force the heart to pump. Often, once circulation starts, the patient begins breathing again spontaneously.

Step 3: The Proper CPR Sequence

If the person doesn't wake up, begin a rhythm of three chest presses followed by one mouth-to-mouth breath. Lock your elbows and press hard to ensure the heart is being squeezed between the bones. This specific cycle keeps oxygenated blood moving to the brain, preventing permanent damage during a cardiac emergency.

How Common Are Heart Attacks?

According to the Centers for Disease Control and Prevention, heart attacks claim a life every 34 seconds. In 2023, it caused nearly 920,000 deaths, one in every three recorded. Hence it is important to know not just the ways to help when someone has a heart attack but also how to prevent them.

Heart attacks need immediate intervention, and Dr. Balbir revealed one medicine that can save a life when this is happening: Aspirin. In an interview with HealthandMe, Dr. Balbir Singh revealed that one does not need fancy equipment to help a person having a heart attack.

“If the history of the family history or cholesterol or diabetic. This patient is at risk, so what is the medicine if you get such a symptom? Aspirin.”

What Medicine Can Help a Heart Attack?

Dr. Singh points out that if you or someone near you begins to experience symptoms of a heart attack, such as heavy chest pain, pressure, or unexplained sweating, taking a dissolvable aspirin immediately can be a lifesaver.

By dissolving a tablet (like Dispirin) in a glass of water and drinking it, the medicine enters the bloodstream quickly.

Aspirin works by thinning the blood and preventing further clotting in the arteries, which can stop a heart attack from getting worse before medical professionals arrive.

Other Preventative Measures To Take For Heart Attack

Before medical professionals arrive, doing CPR also helps; however, one must know the right way to do CPR.

There is a lot of misinformation online. Dr. Singh mentions a viral video where a person collapses and someone attempts to give them CPR while they are still sitting in a chair. This is a dangerous mistake.

He explained that you cannot perform CPR on someone who is sitting up. The body must be positioned correctly for the heart and lungs to receive the benefit of the chest compressions. If the technique is wrong, the blood will not reach the brain, and your efforts will not help the patient. Understanding the proper sequence of events is the difference between a failed attempt and a saved life.

Step 1: The Importance of Positioning

If someone collapses, immediately place them flat on their back on a hard floor. You need the ground's resistance to pump the heart manually. In this position, the heart is "sandwiched" between the rib cage and spine. On a soft bed, your presses will fail to squeeze the heart effectively.

Step 2: Focus on the Heart First

Dr. Singh emphasizes that restarting the heart is the absolute priority. Place both hands in the center of the chest and use your body weight to press firmly. By pushing the rib cage toward the spine, you force the heart to pump. Often, once circulation starts, the patient begins breathing again spontaneously.

Step 3: The Proper CPR Sequence

If the person doesn't wake up, begin a rhythm of three chest presses followed by one mouth-to-mouth breath. Lock your elbows and press hard to ensure the heart is being squeezed between the bones. This specific cycle keeps oxygenated blood moving to the brain, preventing permanent damage during a cardiac emergency.

How Common Are Heart Attacks?

According to the Centers for Disease Control and Prevention, heart attacks claim a life every 34 seconds. In 2023, it caused nearly 920,000 deaths, one in every three recorded. Hence it is important to know not just the ways to help when someone has a heart attack but also how to prevent them.