The COVID-19 pandemic may be over, but our immune systems are still feeling the impact. After years of battling constant viral threats, from COVID-19 to seasonal flu and other infections, our body’s defense system is exhausted. Many people continue to experience lingering inflammation, frequent illnesses, and slower recovery times. This extended state of immune stress has compromised us further to chronic illness, including autoimmune diseases and even neurodegenerative diseases such as Parkinson's. So why is our immune system still in trouble? And how do we give it its power back? Understanding immune exhaustion is the beginning of rebuilding our body's natural immunity.

A weakened immune system makes people more susceptible to disease, mental illnesses, and even sleep disorders. Now, new research indicates that immune system depletion may play an important role in the onset of Parkinson's disease, a degenerative neurologic disorder that compromises movement and cognition.

Role of Inflammation in Parkinson's Disease

Dysfunctional immune response is a leading cause of long-standing inflammation within the body, that has been found to contribute towards a multitude of conditions, including cardiovascular conditions, diabetes, depression, and neurodegenerative diseases such as Alzheimer's.

As people age, their immune system naturally becomes less effective. This deterioration, referred to as immune exhaustion, may be a key contributor to the onset and progression of Parkinson’s disease. Rebecca Wallings, a Parkinson’s Foundation Launch Award grant recipient and senior postdoctoral fellow at the University of Florida, believes that an accumulation of exhausted immune cells could be driving neurodegeneration in Parkinson’s patients.

How a Tired Immune System Might Affect Parkinson's?

Parkinson's disease is most commonly linked with the degeneration and loss of dopaminergic neurons—motor nerve cells that produce dopamine, an essential neurotransmitter for movement. While researchers have long suspected inflammation is involved in this neurodegeneration, the mechanisms are not yet well understood.

Wallings' study is on immune cell exhaustion, a process by which aging immune cells fail to control immune responses effectively. Her research indicates that instead of dampening inflammation in Parkinson's patients, attempts should be made to rejuvenate the immune system to regain its functionality.

Energy Deficiency in Immune Cells

One of the major findings of Wallings' work is the function of mitochondrial impairment in immune cell exhaustion. Mitochondria are commonly called the powerhouses of cells, as they are vital for generating energy. As mitochondria age and become inefficient, immune cells fail to function well, potentially accelerating neurodegeneration in Parkinson's disease.

Wallings has found that mutations in the LRRK2 gene, a recognized genetic risk factor for Parkinson's disease, are linked with defective mitochondrial function and immune cell exhaustion. Her current work includes testing various therapeutic approaches to restore mitochondrial function in immune cells with the potential to enhance the immune system and potentially prevent or treat Parkinson's disease.

Will Rejuvenating the Immune System Help in Treatment?

For decades, the standard practice in treating Parkinson's has been to suppress brain inflammation. Yet Wallings' work indicates that instead of slowing down immune responses, restoring the immune system could be a more successful strategy. By addressing mitochondrial impairment and immune resilience, researchers can potentially reverse or slow down Parkinson's disease.

Wallings is now looking into how to rejuvenate immune cells by fixing mitochondria. She studies immune cells from patients with Parkinson's as well as from healthy subjects and performs experiments on animal models to determine if rejuvenation of the immune system could result in improved disease outcomes.

Lifestyle Factors That May Affect Parkinson's Risk

While there is no cure for Parkinson's disease, some lifestyle adjustments may decrease the chances of developing the illness. Since neurodegenerative diseases are associated with chronic inflammation and immune dysfunction, developing habits that enhance immune function might prove helpful.

Diet: There is evidence to suggest that eating in accordance with the Mediterranean or MIND diets, both high in antioxidants, healthy fats, and anti-inflammatory foods, can encourage brain wellness and reduce Parkinson's risk.

Avoiding Dangerous Substances: Restricting alcohol and nicotine use can maintain a robust immune system and suppress inflammation.

Reducing Stress: Chronic stress weakens immune function, so methods such as meditation, exercise, and sufficient sleep can lead to improved overall well-being.

On February 13, Canadians across the country mark Wear Red Canada Day, a reminder that heart disease remains the leading cause of death for women. Yet despite the scale of the problem, many women still do not recognize their risk or their symptoms.

“We’re learning more and more each day about how heart disease uniquely affects women,” said nurse practitioner and researcher Rachel Ollivier in an interview with CTV News. She emphasized that awareness is still lagging, both among patients and within health-care systems.

According to the World Health Organization, cardiovascular disease accounts for roughly one in three deaths among women globally. In Canada, heart disease and stroke continue to be leading causes of death among women, and women are less likely than men to receive timely diagnosis or treatment.

Symptoms Can Look Different

Chest pain remains the most common heart attack symptom in both men and women. But Ollivier explained that women’s symptoms can often be subtler or feel different.

“For women, they often uniquely experience chest pain that seems like more of a discomfort or a tightness in the chest,” she said. Some women may feel pain in the left arm or jaw, unusual fatigue, nausea, vomiting, or discomfort between the shoulder blades.

Because these symptoms can be less specific, they are sometimes dismissed as stress, anxiety, indigestion, or exhaustion. Social factors also play a role. Women often juggle multiple responsibilities at home and work, and may delay seeking care. In some cases, their concerns may also be minimized within health-care settings.

Medical differences matter too. Women typically have smaller hearts and arteries, and plaque buildup behaves differently compared to men. Conditions such as spontaneous coronary artery dissection and microvascular dysfunction are seen more commonly in women, making diagnosis more complex.

Hormones and the Hidden Risk Window

Beyond symptoms, experts are urging greater recognition of the role hormones play in lifelong heart health.

“Endogenous estrogen is cardio protective,” Ollivier explained. As women enter the perimenopausal transition, estrogen levels fluctuate and gradually decline, and that protection is lost. This shift can lead to higher cholesterol levels and changes in fat distribution, increasing cardiovascular risk, particularly between the ages of 40 and 60.

Colleen Norris, a nursing professor at the University of Alberta and research lead of the CKHui LHHW Women’s Heart Health Research Collaborative who wrote on Yahoo Canada, believes the conversation needs to go even deeper.

She argues that ovaries have long been viewed only through the lens of reproduction. “The ovaries are not just reproductive organs. They are architects of women’s health across the lifespan,” she noted. Estrogen influences the heart and blood vessels, but also the brain, bones, kidneys, metabolism, and immune function.

Most women are never told that ovarian reserve and estrogen levels begin declining in their late 30s. By the time noticeable symptoms appear, biological changes may have already been underway for years.

Menopause itself is just one day, Norris explained. The larger reproductive transition surrounding it is what significantly increases vulnerability to chronic disease. Yet the health-care system often waits until disease develops before intervening.

Moving From Awareness to Action

Both experts stress that education is critical. Women with conditions such as polycystic ovary syndrome, pregnancy complications like preeclampsia or gestational diabetes, and those entering midlife should be particularly mindful of their cardiovascular risk.

Wear Red Canada Day is meant to spark awareness, but symbols alone are not enough. Experts are calling for better research funding focused on midlife women, improved medical education around ovarian aging, and more proactive screening during the reproductive transition.

Heart disease in women is not inevitable. But recognizing that symptoms can differ, and that hormonal shifts matter, could be lifesaving.

Seychelles Chikungunya Virus Outbreak: The United States warned travelers to be careful if they plan to visit the Seychelles islands anytime soon as it is currently undergoing a chikungunya outbreak. As per the Centers for Disease Control and Prevention (CDC), a 'Level 2' advisory for the island has been issued and travelers have been asked to 'practice enhanced precautions' if they do plan to visit.

Unique Symptoms Of Chikungunya: What Is The Disease?

Chikungunya is a mosquito-borne viral disease transmitted primarily by Aedes aegypti and Aedes albopictus, the same mosquitoes that spread dengue fever. Symptoms typically appear three to seven days after a bite and include sudden fever, severe joint pain, headache, nausea, fatigue, and rash in about half of cases.

However, there are certain unique symptoms of chikungunya. For instance, unlike a Dengue fever, chikungunya leaves lingering effects along with joint pain and fatigue that lasts up to weeks.

Unique Symptoms of Chikungunya: What Are They?

While common symptoms like high fever often >102 degree F is common there are other symptoms too, which includes:

• Headache
• Muscle pain
• Fatigue
• Joint Swelling

• Some unique symptoms of this disease includes neurological complications such as rare instances that could lead to encephalitis or the inflammation of the brain, meningitis, or severe nerve issues like Guillain-Barré syndrome.

• Ocular symptoms include red eyes like conjunctivitis, eye pain, or temporary vision problems.

• Unique symptoms could also include bleeding, while it is more common in Dengue, rare bleeding from gums and nose could occur in Chikungunya.

• Other unique symptoms may include chronic and persistent symptoms like joint pain that does not subside after the initial week and lasts for months or even years.

• Other symptoms include cardiovascular and respiratory issues and skin manifestation, which could go beyond the common rash. Some patients may experience vasculitis-like skin lesions.

Unique Symptoms of Chikungunya: How Long Does It Last?

Chikungunya symptoms usually occur with in 3 to 7 days after a bite. However, the symptoms could often last long. While fever could subside in a day or two, chronic symptoms especially like joint pain and muscle pain could last for months. Weakness too could persist.

Unique Symptoms Of Chikungunya: Outbreak In Seychelles Led To US Issuing Travel Advisory

A Level 2 travel advisory has been issued, which means the travelers are expected to practice enhanced precautions as compared to a Level 1 advisory that only asks travelers to practice usual precautions.

In more serious cases, Level 3 advisory is issued that asks travelers to reconsider non-essential travel, whereas a Level 4 advisory asks travelers to avoid all travel.

Read: CDC Travel Advisory Issued For These Islands Amid Chikungunya Outbreak

As CDC issues travel advisory, here is what travelers are expected to do:

• Travelers are expected to protect themselves by preventing mosquito bites, which includes using insect repellent, wearing long-sleeved shirts and pants, and staying in places where air conditioning or that have screens on the windows and doors
• The CDC also tells travelers to get vaccinated for those who are visiting the area affected by a chikungunya outbreak
• If a traveler is pregnant, they are asked to reconsider travel to affected area, especially if they are closed to delivering their baby. Mothers infected around the time of delivery can pass the virus to their baby before or during delivery. Newborns infected in this way or by a mosquito bite are at risk for severe illness, including poor long-term outcomes
• If someone has a fever, joint pain, headache, muscle pain, joint swelling, or rash during or after the travel, they must seek medical care

Why do some relationships feel effortless and magnetic, while others slowly unravel despite our best intentions? According to neuroscientist Andrew Huberman, the answers lie deep within our early childhood experiences and the intricate wiring of the brain.

In a recent episode of Huberman Lab titled “Essentials: The Science of Love, Desire & Attachment,” Huberman explores how biology and psychology work together to shape the way we connect, commit, and sometimes drift apart. What makes the conversation compelling is how it bridges hard science with very human emotions.

Our First Bonds Shape Our Love Stories

Huberman begins with a powerful idea: the way we love as adults often echoes how we were loved as children.

He refers to the landmark “Strange Situation” experiment by psychologist Mary Ainsworth. In this study, toddlers were briefly separated from their caregivers and then reunited. Researchers closely observed how the children reacted. Some felt secure and soothed upon return. Others were anxious, avoidant, or distressed.

These early attachment patterns, Huberman explains, frequently resurface in adult romantic relationships. A securely attached child may grow into a partner who trusts and communicates well. An anxious child may become someone who fears abandonment. An avoidant child may struggle with emotional closeness.

The hopeful part? These patterns are not destiny. Awareness allows change. Once people recognize their emotional blueprint, they can reshape it.

Love Is Not in One Spot in the Brain

Romantic connection is not housed in a single “love center.” Instead, multiple brain regions activate in sequence to create desire, attraction, empathy, and long term bonding.

Huberman clears up a common myth about dopamine. Many people think of it as the pleasure chemical. In reality, it is more about motivation and pursuit. Dopamine fuels craving and drives us toward a person we find compelling. It is the chemical that makes you check your phone, wait for a message, or feel a rush at the thought of someone.

But desire alone does not sustain love.

For deeper attachment, empathy circuits come into play. The prefrontal cortex and the insula are especially important. The insula helps us sense our internal bodily state, a process known as interoception. It allows us to feel our own emotions while tuning into someone else’s. This shared emotional awareness strengthens bonds.

The Role of “Positive Delusion”

One of the most fascinating ideas Huberman discusses is what he calls “positive delusion.” For long term stability, the brain benefits from believing that your partner is uniquely special. This slight bias, almost a romantic illusion, reinforces commitment.

It is not about ignoring flaws. It is about genuinely feeling that this person, out of billions, holds a singular place in your emotional world. Biologically, this strengthens attachment pathways.

Why Relationships Fall Apart

Huberman also references research from the Gottman Lab at the University of Washington. Decades of data reveal four behaviors that predict relationship breakdown: criticism, defensiveness, stonewalling, and contempt.

Stonewalling happens when one partner emotionally withdraws and stops responding. But the most toxic behavior is contempt. Researchers have described it as acid to a relationship because it corrodes trust and shuts down empathy. Once contempt takes root, the neural circuits that support connection begin to weaken.

In the end, love is both chemistry and choice. Our brains may set the stage, but awareness, empathy, and daily behavior determine whether attachment deepens or quietly falls away.