The COVID-19 pandemic may be over, but our immune systems are still feeling the impact. After years of battling constant viral threats, from COVID-19 to seasonal flu and other infections, our body’s defense system is exhausted. Many people continue to experience lingering inflammation, frequent illnesses, and slower recovery times. This extended state of immune stress has compromised us further to chronic illness, including autoimmune diseases and even neurodegenerative diseases such as Parkinson's. So why is our immune system still in trouble? And how do we give it its power back? Understanding immune exhaustion is the beginning of rebuilding our body's natural immunity.

A weakened immune system makes people more susceptible to disease, mental illnesses, and even sleep disorders. Now, new research indicates that immune system depletion may play an important role in the onset of Parkinson's disease, a degenerative neurologic disorder that compromises movement and cognition.

Role of Inflammation in Parkinson's Disease

Dysfunctional immune response is a leading cause of long-standing inflammation within the body, that has been found to contribute towards a multitude of conditions, including cardiovascular conditions, diabetes, depression, and neurodegenerative diseases such as Alzheimer's.

As people age, their immune system naturally becomes less effective. This deterioration, referred to as immune exhaustion, may be a key contributor to the onset and progression of Parkinson’s disease. Rebecca Wallings, a Parkinson’s Foundation Launch Award grant recipient and senior postdoctoral fellow at the University of Florida, believes that an accumulation of exhausted immune cells could be driving neurodegeneration in Parkinson’s patients.

How a Tired Immune System Might Affect Parkinson's?

Parkinson's disease is most commonly linked with the degeneration and loss of dopaminergic neurons—motor nerve cells that produce dopamine, an essential neurotransmitter for movement. While researchers have long suspected inflammation is involved in this neurodegeneration, the mechanisms are not yet well understood.

Wallings' study is on immune cell exhaustion, a process by which aging immune cells fail to control immune responses effectively. Her research indicates that instead of dampening inflammation in Parkinson's patients, attempts should be made to rejuvenate the immune system to regain its functionality.

Energy Deficiency in Immune Cells

One of the major findings of Wallings' work is the function of mitochondrial impairment in immune cell exhaustion. Mitochondria are commonly called the powerhouses of cells, as they are vital for generating energy. As mitochondria age and become inefficient, immune cells fail to function well, potentially accelerating neurodegeneration in Parkinson's disease.

Wallings has found that mutations in the LRRK2 gene, a recognized genetic risk factor for Parkinson's disease, are linked with defective mitochondrial function and immune cell exhaustion. Her current work includes testing various therapeutic approaches to restore mitochondrial function in immune cells with the potential to enhance the immune system and potentially prevent or treat Parkinson's disease.

Will Rejuvenating the Immune System Help in Treatment?

For decades, the standard practice in treating Parkinson's has been to suppress brain inflammation. Yet Wallings' work indicates that instead of slowing down immune responses, restoring the immune system could be a more successful strategy. By addressing mitochondrial impairment and immune resilience, researchers can potentially reverse or slow down Parkinson's disease.

Wallings is now looking into how to rejuvenate immune cells by fixing mitochondria. She studies immune cells from patients with Parkinson's as well as from healthy subjects and performs experiments on animal models to determine if rejuvenation of the immune system could result in improved disease outcomes.

Lifestyle Factors That May Affect Parkinson's Risk

While there is no cure for Parkinson's disease, some lifestyle adjustments may decrease the chances of developing the illness. Since neurodegenerative diseases are associated with chronic inflammation and immune dysfunction, developing habits that enhance immune function might prove helpful.

Diet: There is evidence to suggest that eating in accordance with the Mediterranean or MIND diets, both high in antioxidants, healthy fats, and anti-inflammatory foods, can encourage brain wellness and reduce Parkinson's risk.

Avoiding Dangerous Substances: Restricting alcohol and nicotine use can maintain a robust immune system and suppress inflammation.

Reducing Stress: Chronic stress weakens immune function, so methods such as meditation, exercise, and sufficient sleep can lead to improved overall well-being.

When John Cena started noticing blurry vision, he assumed it was simply part of getting older. But the worsening eyesight was also accompanied by redness, itchiness and crusting around his eyes.

“I had a lot of redness and itchiness, and every once in a while, waking up with eye crusties and stuff. At the same time, given my age — I'm 49 now — my vision was going a little bit, so I just figured it was par for the course. But because my vision was going, I needed to see if I needed glasses or prescriptions.”

Until then, Cena had delayed getting his eyes checked. He believed that the symptoms were caused by bright lights, excessive screen time or ageing.

However, an eye examination gave him a surprise. Cena learned that his symptoms were caused by Demodex blepharitis, a condition he says he had never heard of.

“Diagnosed with Demodex blepharitis, which I didn't even know existed.”

What Are Demodex Mites?

Also read: Study Decodes Why COVID Survivors Continue To Suffer Vision Problems

Demodex mites are tiny, eight-legged organisms that live naturally on human skin, particularly around hair follicles. Measuring just 0.15 to 0.4 millimeters, they are invisible to the naked eye but are present on the skin of almost every adult.

These microscopic mites feed on sebum (the skin's natural oil) and dead skin cells, helping remove accumulated debris under normal conditions.

How Do Demodex Mites Work?

Demodex mites are most active at night. They emerge from hair follicles after sunset because ultraviolet (UV) light is harmful to them. While people sleep, the mites feed, crawl and reproduce on the skin's surface.

They are also believed to be stimulated by melatonin, the hormone that helps regulate sleep, creating a unique relationship between humans and these naturally occurring organisms.

When Can Demodex Mites Become A Problem?

Although harmless in small numbers, Demodex mites can cause problems if they multiply excessively—a condition known as demodicosis.

According to Dr. Richard Locksley, professor of medicine at the University of California, San Francisco, an overgrowth of Demodex mites can contribute to:

• Rosacea
• Blepharitis (eyelid inflammation)
• Acne-like breakouts
• Itchy, inflamed skin

Read More: Wegovy More Likely To Cause Rare Blindness Than Ozempic And Other Similar Drugs, Recent Study Finds

People with weakened immune systems are particularly vulnerable because their bodies may be less able to control mite populations. In addition, inadequate sleep may increase oil production, providing more nourishment for the mites.

Should You Be Worried?

For most healthy people, Demodex mites are a normal part of the skin microbiome and are not considered harmful. Problems generally arise only when their numbers increase significantly.

To help reduce the risk of overgrowth:

• Wash your face every night with a gentle, non-comedogenic cleanser to remove excess oil and debris.
• Remove eye makeup and false eyelashes before bed, as these can encourage mite buildup.
• Get adequate sleep, since poor sleep may increase sebum production.
• Consult a dermatologist if you experience persistent redness, itching or inflammation around the eyes or skin.

Common Sports Injuries and How to Prevent Them by Dr Sumit Batra. Whether you're training for a marathon, playing pickleball with friends, or simply trying to stay fit at the gym, being active is one of the best things you can do for your health. But every sport is unique and places different demands on your body. Without the right preparation, even a fun weekend workout can leave you with an injury that keeps you on the sidelines. Often, I see people whose injuries could have been avoided by warming up properly, increasing their training slowly, and paying attention to pain. Many think the pain will go away on its own, but getting it checked early can help prevent bigger problems.

Several types of common sports injuries show up suddenly, while others build up over time. Ankle sprains are among the most common. They usually happen when the foot rolls awkwardly during running, jumping, or changing direction quickly. Simultaneously, Knee injuries are another common problem, especially in sports that involve sudden stops, pivots, or jumps, so the ligaments, cartilage, or tendons around the knee can be affected, making movement painful and unstable.

Muscle strains in the hamstrings and calves often occur when muscles are pushed harder than they're ready for. Skipping a warm-up or increasing the intensity of your workouts too quickly can raise the risk.

Athletes who play cricket, tennis, or volleyball, or who spend long hours swimming, may also develop shoulder pain due to repeated overhead movements. And then there are overuse injuries like tennis elbow, shin splints, and Achilles tendinitis, which develop slowly after repeated stress without enough recovery.

How to Reduce Your Risk

The good news is that most sports injuries can be prevented. Start every workout with a proper warm-up. Just five to ten minutes of light movement and stretching can help prepare your muscles and joints for exercise.

Strength training is equally important. Strong muscles support your joints, improve balance, and help your body absorb the impact of running, jumping, and lifting.

It's also important not to rush your progress. Whether you're preparing for a race or trying heavier weights, increasing the intensity little by little gives your body time to adapt safely.

Recovery deserves just as much attention as training. Good sleep, proper hydration, balanced meals, rest days, and well-fitting sports shoes all play a role in keeping injuries away.

Listen to What Your Body Is Telling You

Always listen to your body—it often gives warning signs before it's too late. Feeling sore after a challenging workout is completely normal. But pain that doesn't improve, swelling, difficulty putting weight on a limb, or restricted movement shouldn't be ignored. Getting the injury checked early often means a quicker recovery and lowers the chances of long-term problems. Sports injuries can happen to anyone, whether you are a seasoned athlete or someone who enjoys staying active on weekends. A little preparation, sensible training, and adequate recovery can go a long way in preventing them. And if something doesn't feel right, don't wait for it to get worse. Early care can make all the difference in getting you back to doing what you love.

Dr. Sumit Batra, Consultant Orthopaedic & Spine Surgeon at PB Health

Gone are the days when constipation was considered a problem only among older adults. Today, an increasing number of young professionals are experiencing irregular bowel movements, bloating, abdominal discomfort, and a constant feeling of incomplete evacuation. The fast-paced corporate lifestyle, long working hours, unhealthy eating habits, and chronic stress have made constipation a common digestive concern among people in their 20s and 30s.

One of the biggest contributors is a sedentary lifestyle. Many professionals spend eight to ten hours sitting at a desk, with little time for physical activity. Regular movement helps stimulate bowel function, and a lack of it can slow down digestion. Another common cause is poor dietary habits. Skipping breakfast, relying on processed or fast foods, and consuming inadequate amounts of fibre can significantly affect bowel health.

Hydration also plays a vital role. Busy schedules often lead people to consume more coffee or tea while neglecting water intake. Dehydration makes stools harder and more difficult to pass, increasing the risk of constipation. Stress is another major factor. Deadlines, work pressure, and poor sleep can disrupt the communication between the brain and the gut, affecting normal bowel movements. Ignoring the natural urge to pass stools due to meetings or travel can further worsen the condition over time.

The good news is that constipation can often be managed through simple lifestyle changes. A balanced diet rich in fibre from fruits, vegetables, whole grains, legumes, and nuts helps add bulk to stools and promotes regular bowel movements. Drinking at least two to three litres of water daily keeps stools soft and easier to pass.

Regular physical activity is equally important. Even a brisk 30-minute walk, stretching during work breaks, or choosing stairs over elevators can improve gut motility. Maintaining a consistent toilet routine, preferably after breakfast, and responding promptly to the body's natural urge can also help establish healthy bowel habits.

Stress management should not be overlooked. Practising yoga, meditation, deep breathing exercises, or simply ensuring adequate sleep can positively influence digestive health. Limiting excessive consumption of processed foods and caffeinated beverages can also reduce the risk of constipation.

While occasional constipation is usually not a cause for concern, persistent symptoms lasting more than three weeks, severe abdominal pain, blood in the stool, unexplained weight loss, or constipation alternating with diarrhoea should never be ignored. These could indicate an underlying medical condition that requires evaluation by a gastroenterologist.

Healthy digestion is closely linked to overall well-being and productivity. By adopting healthier daily habits and paying attention to digestive health, young professionals can prevent constipation, improve their quality of life, and maintain better physical and mental performance at work.

By Dr. Pradeepta Kumar Sethy, Director, Gastroenterology, Manipal Hospital, EM Bypass & Mukundupur