The COVID-19 pandemic may be over, but our immune systems are still feeling the impact. After years of battling constant viral threats, from COVID-19 to seasonal flu and other infections, our body’s defense system is exhausted. Many people continue to experience lingering inflammation, frequent illnesses, and slower recovery times. This extended state of immune stress has compromised us further to chronic illness, including autoimmune diseases and even neurodegenerative diseases such as Parkinson's. So why is our immune system still in trouble? And how do we give it its power back? Understanding immune exhaustion is the beginning of rebuilding our body's natural immunity.

A weakened immune system makes people more susceptible to disease, mental illnesses, and even sleep disorders. Now, new research indicates that immune system depletion may play an important role in the onset of Parkinson's disease, a degenerative neurologic disorder that compromises movement and cognition.

Role of Inflammation in Parkinson's Disease

Dysfunctional immune response is a leading cause of long-standing inflammation within the body, that has been found to contribute towards a multitude of conditions, including cardiovascular conditions, diabetes, depression, and neurodegenerative diseases such as Alzheimer's.

As people age, their immune system naturally becomes less effective. This deterioration, referred to as immune exhaustion, may be a key contributor to the onset and progression of Parkinson’s disease. Rebecca Wallings, a Parkinson’s Foundation Launch Award grant recipient and senior postdoctoral fellow at the University of Florida, believes that an accumulation of exhausted immune cells could be driving neurodegeneration in Parkinson’s patients.

How a Tired Immune System Might Affect Parkinson's?

Parkinson's disease is most commonly linked with the degeneration and loss of dopaminergic neurons—motor nerve cells that produce dopamine, an essential neurotransmitter for movement. While researchers have long suspected inflammation is involved in this neurodegeneration, the mechanisms are not yet well understood.

Wallings' study is on immune cell exhaustion, a process by which aging immune cells fail to control immune responses effectively. Her research indicates that instead of dampening inflammation in Parkinson's patients, attempts should be made to rejuvenate the immune system to regain its functionality.

Energy Deficiency in Immune Cells

One of the major findings of Wallings' work is the function of mitochondrial impairment in immune cell exhaustion. Mitochondria are commonly called the powerhouses of cells, as they are vital for generating energy. As mitochondria age and become inefficient, immune cells fail to function well, potentially accelerating neurodegeneration in Parkinson's disease.

Wallings has found that mutations in the LRRK2 gene, a recognized genetic risk factor for Parkinson's disease, are linked with defective mitochondrial function and immune cell exhaustion. Her current work includes testing various therapeutic approaches to restore mitochondrial function in immune cells with the potential to enhance the immune system and potentially prevent or treat Parkinson's disease.

Will Rejuvenating the Immune System Help in Treatment?

For decades, the standard practice in treating Parkinson's has been to suppress brain inflammation. Yet Wallings' work indicates that instead of slowing down immune responses, restoring the immune system could be a more successful strategy. By addressing mitochondrial impairment and immune resilience, researchers can potentially reverse or slow down Parkinson's disease.

Wallings is now looking into how to rejuvenate immune cells by fixing mitochondria. She studies immune cells from patients with Parkinson's as well as from healthy subjects and performs experiments on animal models to determine if rejuvenation of the immune system could result in improved disease outcomes.

Lifestyle Factors That May Affect Parkinson's Risk

While there is no cure for Parkinson's disease, some lifestyle adjustments may decrease the chances of developing the illness. Since neurodegenerative diseases are associated with chronic inflammation and immune dysfunction, developing habits that enhance immune function might prove helpful.

Diet: There is evidence to suggest that eating in accordance with the Mediterranean or MIND diets, both high in antioxidants, healthy fats, and anti-inflammatory foods, can encourage brain wellness and reduce Parkinson's risk.

Avoiding Dangerous Substances: Restricting alcohol and nicotine use can maintain a robust immune system and suppress inflammation.

Reducing Stress: Chronic stress weakens immune function, so methods such as meditation, exercise, and sufficient sleep can lead to improved overall well-being.

As the FIFA World Cup 2026 is underway, players are navigating demanding training schedules, frequent travel, challenging weather conditions, and the pressure to perform at their peak. Amid these challenges, many elite footballers quietly face an often-overlooked problem off the field: sleep disturbances.

In an exclusive interview with HealthandMe, Dr. P.S.M. Chandran, former Director of Sports Medicine at the Sports Authority of India (SAI), said that the stress, anxiety, and disrupted routines associated with elite sport can make it difficult for players to get adequate rest. In some cases, these challenges may drive athletes toward sleeping medications, potentially affecting both their health and on-field performance.

Dr. Chandran, currently President of the Indian Federation of Sports Medicine (IFSM), said that while players may turn to sleeping pills as a quick solution, regular use can become a habit that leads to dependence if left unchecked.

Recently, striker Omar Bogle, who plays for Crewe Alexandra in League Two, shared his story with The New York Times' The Athletic about the moment last year when he became addicted to sleeping pills and painkillers.

What began as a way to help him sleep after suffering a back fracture during pre-season in the summer of 2024 became an addiction.

From January 2025, his usage accelerated to an alarming level. He said that many of the pills he was taking were benzodiazepines, such as diazepam and lorazepam. He was also using the stronger zopiclone pills, which the NHS says can be prescribed for the short-term treatment of severe insomnia.

"No one knew the extent of what I was doing," he said. "I never told anyone I was popping 18 or 19 of the things in the night."

Bogle's is not alone.

Also read: FIFA World Cup 2026: What Keeps Messi and Ronaldo Biologically Younger Than Their Age? Experts Explain

In January 2026, former England midfielder Jonjo Shelvey revealed on a podcast how he had become addicted to sleeping pills because of the loneliness he experienced while playing in Turkey. Shelvey said his dependence affected his relationship with his children.

Former Manchester United midfielder Darron Gibson also developed a sleeping pill addiction and, at his worst point, was taking 12 to 14 tablets a night, according to The New York Times.

In 2023, former Tottenham Hotspur and England midfielder Dele Alli told the BBC that he had become addicted to sleeping pills to block out past traumas.

According to Dr. Chandran, the issue is not unique to football but affects athletes across multiple sports, driven by stress, performance pressures, injuries, and demanding schedules.

"Football is not an exception," Dr. Chandran said. "Because of its popularity, we hear more about football players, but athletes in other sports face similar problems."

Why Elite Footballers Face Sleep Issues?

Elite footballers operate in a high-pressure environment where careers can be influenced by contracts, team selection, injuries, and performance expectations. Frequent travel, changing time zones, training camps, and irregular eating patterns can further disrupt normal sleep cycles.

According to Dr. Chandran, these factors create significant psychological stress, making it difficult for athletes to unwind and get adequate rest.

"Athletes are always stressed because of their contracts with clubs, their interaction with coaches, and concerns about injuries that can affect their income," he explained. "All these tensions bring stress, and stress leads to sleep disturbance."

Read More: Heading to FIFA World Cup 2026? Here's How to Stay Safe From Measles, Heatstroke

Why Athletes Turn to Sleeping Pills

Sleep plays a crucial role in athletic recovery. Without adequate rest, muscle repair, mental focus, and physical performance can suffer.

"If athletes do not get good sleep, the next day's training will suffer," Dr. Chandran said. "To get better sleep, they try sleeping pills. That becomes an escape route for them."

However, he warned that regular use of sleeping medications can quickly develop into dependence.

"Once they start taking sleeping pills, it becomes a habit. It is difficult to get out of it," he told HealthandMe.

The expert noted that while occasional use under medical supervision may be appropriate in certain situations, unsupervised and prolonged use can worsen sleep problems and lead to dependence.

Also read: 22 Treated For Heat Illness At FIFA Fan Festival: How Are World Cup Players Protected?

The Role of Stress Hormones

Stress hormones such as cortisol, adrenaline, and noradrenaline are naturally involved in exercise and performance. However, elevated stress levels can interfere with healthy sleep patterns.

These hormones increase alertness, heart rate, and metabolic activity—responses that may be useful during competition but can make it difficult to fall asleep afterward.

Dr. Chandran emphasized that athletes should seek professional guidance when dealing with sleep issues rather than relying on self-medication.

Recovery Is Key to Performance

Modern sports science places a strong emphasis on recovery, recognizing it as an essential component of performance. Elite football clubs now employ teams of physiotherapists, psychologists, nutritionists, doctors, and recovery specialists to help athletes maintain optimal health.

"Training leads to tiredness, and tiredness has to be overcome by recovery methods," Dr. Chandran said. "The better you recover, the better you can perform the next day."

The loss of a tooth is often viewed as a purely dental concern, but its impact extends far beyond appearance. Missing teeth can affect chewing efficiency, speech, facial structure, and even emotional well-being. While traditional tooth replacement options have served patients for decades, modern implant dentistry has transformed the way tooth loss is managed. Today, dental implants are not merely about filling a gap; they are about restoring function, confidence, and overall quality of life.

Restoring Natural Function and Comfort

Dr. Achuth M. Baliga, Director, Happiest Pearls, said, "One of the greatest advantages of dental implants is their ability to closely replicate the function of natural teeth. Unlike removable dentures that may shift or cause discomfort, implants are anchored securely within the jawbone, providing exceptional stability. This allows individuals to chew a wider variety of foods with confidence and comfort."

The expert went on to say that proper chewing is essential for nutrition and digestive health. Patients who struggle with missing teeth often avoid certain foods such as fruits, vegetables, nuts, and proteins, potentially compromising their dietary intake. By restoring full chewing efficiency, dental implants help individuals maintain a balanced and nutritious diet, contributing to better overall health. Dr Baliga also answered more FAQs on the subject.

Preserving Jawbone and Facial Structure

Tooth loss triggers a process known as bone resorption, where the jawbone gradually deteriorates due to the absence of stimulation from the tooth root. Over time, this can lead to changes in facial appearance, including a sunken or prematurely aged look.

Dental implants address this challenge by functioning like artificial tooth roots. They stimulate the surrounding bone during everyday activities such as chewing, helping to preserve bone volume and density. This not only supports long-term oral health but also helps maintain natural facial contours. In many cases, implants play a significant role in preserving a youthful appearance and preventing the structural changes associated with prolonged tooth loss.

Rebuilding Confidence and Self-Esteem

The psychological effects of missing teeth are often underestimated. Individuals may become self-conscious about smiling, speaking, or interacting socially. Concerns about appearance can affect personal relationships, professional interactions, and overall self-confidence.

Dental implants provide a fixed and natural-looking solution that blends seamlessly with surrounding teeth. The ability to smile without hesitation and speak without worrying about movement or instability can have a profound impact on emotional well-being. Many patients report feeling more confident in social settings and more comfortable expressing themselves after completing implant treatment.

Supporting Better Speech and Daily Living

Missing teeth, particularly in the front of the mouth, can interfere with pronunciation and speech clarity. Similarly, loose or ill-fitting dentures may cause slurring or difficulty articulating certain sounds.

Because implants are securely integrated into the jawbone, they provide the stability needed for clear and natural speech. Everyday activities such as eating in public, participating in meetings, or engaging in conversations become more comfortable and predictable. These seemingly small improvements can significantly enhance daily living and social participation.

Advancements Making Treatment More Predictable

Modern implant dentistry has benefited greatly from technological innovations. Digital imaging, three-dimensional treatment planning, guided implant placement, and advanced restorative materials have improved precision and predictability. These advancements allow clinicians to tailor treatment plans to each patient's unique anatomy and functional requirements.

In addition, improved understanding of bone biology and soft tissue management has contributed to higher success rates and more aesthetically pleasing outcomes. As a result, implant therapy has become a reliable long-term solution for a wide range of patients experiencing tooth loss.

A Comprehensive Approach to Oral Health

Implant dentistry today is centred on patient outcomes rather than simply replacing missing teeth. The goal is to restore oral function, maintain facial structure, support emotional well-being, and improve overall quality of life. Successful treatment considers not only the clinical aspects of tooth replacement but also the patient's lifestyle, expectations, and long-term health needs.

India has a physical inactivity problem that is contributing to a growing burden of joint and musculoskeletal disorders among its working-age population. Close to half of Indian adults were insufficiently active in 2022, according to a Lancet study, and among women, that figure climbed to 57%. Behind those numbers is a generation whose muscles have quietly stopped supporting their joints and whose weight has quietly started punishing them for it.

Also Read: Can A Heatwave Affect The IVF Process In A Lab?

Why do Indians struggle with weak, ageing knees?

In an interview with Health and Me, Dr Deepak Gautam, Sr. Consultant Orthopaedic & Robotic Joint Replacement Surgeon, Apollo Hospitals, Navi Mumbai, explained how a patient's knees can start ageing faster than their actual biological age.

Young Indians broadly assume joint problems are inherited with age. Clinical practice keeps demonstrating that they are earned much earlier, through years of small daily choices that never feel consequential until they are. The best time to address this is before a patient ever needs to describe where it hurts.

The knee absorbs roughly four times a person's body weight with every step. Add excess weight over several years, and that force erodes cartilage far ahead of schedule. Obesity also drives systemic inflammation through the release of molecules from fat tissue, which attack joint cells independently of any mechanical load. Patients frequently describe their pain as having an insidious onset and, at times, being sudden. Clinically, joint degeneration develops gradually over many years before symptoms become apparent.

Read more: Feeling Weak In Your Knees? Here Are Tips To Maintain Them As You Age

What are the consequences of weak knees?

Muscle weakness makes that threshold arrive sooner. The quadriceps and core do the work of absorbing shock and stabilising the joint under load. Sedentary work strips that capacity away gradually, and screen time beyond three hours a day has been directly linked to weight gain and metabolic deterioration. For a large portion of India's urban workforce, three hours of daily screen exposure is where the morning starts.

None of this stays contained to the joints. Around one in five Indian adults is already managing several chronic conditions at once, and 45.4% of Indians with coronary heart disease remain physically inactive. Musculoskeletal decline and cardiovascular disease tend to share the same lifestyle roots and reinforce each other. Globally, inactivity rates are still climbing and are expected to reach 35% by 2030, up from 31% in 2022.

When should you take action?

Once cartilage degeneration starts, it is very difficult to reverse the process. We can, however, retard the progression of the disease or prevent it from occurring in the first place. That single fact should change how people think about when to seek help. By the time climbing stairs or a regular walk in the market or garden becomes painful, the window for conservative management has already narrowed.

Waiting for symptoms is the wrong strategy. People with sedentary work patterns, weight above the healthy range, or significant screen exposure should have their joint mobility, gait, and muscle strength assessed before pain enters the picture at all. Resistance training twice a week, clinician-guided weight management, and dietary changes that dial down chronic inflammation are not complicated prescriptions. They are what separates someone who stays mobile in their forties from someone who is discussing surgical options.