The COVID-19 pandemic may be over, but our immune systems are still feeling the impact. After years of battling constant viral threats, from COVID-19 to seasonal flu and other infections, our body’s defense system is exhausted. Many people continue to experience lingering inflammation, frequent illnesses, and slower recovery times. This extended state of immune stress has compromised us further to chronic illness, including autoimmune diseases and even neurodegenerative diseases such as Parkinson's. So why is our immune system still in trouble? And how do we give it its power back? Understanding immune exhaustion is the beginning of rebuilding our body's natural immunity.

A weakened immune system makes people more susceptible to disease, mental illnesses, and even sleep disorders. Now, new research indicates that immune system depletion may play an important role in the onset of Parkinson's disease, a degenerative neurologic disorder that compromises movement and cognition.

Role of Inflammation in Parkinson's Disease

Dysfunctional immune response is a leading cause of long-standing inflammation within the body, that has been found to contribute towards a multitude of conditions, including cardiovascular conditions, diabetes, depression, and neurodegenerative diseases such as Alzheimer's.

As people age, their immune system naturally becomes less effective. This deterioration, referred to as immune exhaustion, may be a key contributor to the onset and progression of Parkinson’s disease. Rebecca Wallings, a Parkinson’s Foundation Launch Award grant recipient and senior postdoctoral fellow at the University of Florida, believes that an accumulation of exhausted immune cells could be driving neurodegeneration in Parkinson’s patients.

How a Tired Immune System Might Affect Parkinson's?

Parkinson's disease is most commonly linked with the degeneration and loss of dopaminergic neurons—motor nerve cells that produce dopamine, an essential neurotransmitter for movement. While researchers have long suspected inflammation is involved in this neurodegeneration, the mechanisms are not yet well understood.

Wallings' study is on immune cell exhaustion, a process by which aging immune cells fail to control immune responses effectively. Her research indicates that instead of dampening inflammation in Parkinson's patients, attempts should be made to rejuvenate the immune system to regain its functionality.

Energy Deficiency in Immune Cells

One of the major findings of Wallings' work is the function of mitochondrial impairment in immune cell exhaustion. Mitochondria are commonly called the powerhouses of cells, as they are vital for generating energy. As mitochondria age and become inefficient, immune cells fail to function well, potentially accelerating neurodegeneration in Parkinson's disease.

Wallings has found that mutations in the LRRK2 gene, a recognized genetic risk factor for Parkinson's disease, are linked with defective mitochondrial function and immune cell exhaustion. Her current work includes testing various therapeutic approaches to restore mitochondrial function in immune cells with the potential to enhance the immune system and potentially prevent or treat Parkinson's disease.

Will Rejuvenating the Immune System Help in Treatment?

For decades, the standard practice in treating Parkinson's has been to suppress brain inflammation. Yet Wallings' work indicates that instead of slowing down immune responses, restoring the immune system could be a more successful strategy. By addressing mitochondrial impairment and immune resilience, researchers can potentially reverse or slow down Parkinson's disease.

Wallings is now looking into how to rejuvenate immune cells by fixing mitochondria. She studies immune cells from patients with Parkinson's as well as from healthy subjects and performs experiments on animal models to determine if rejuvenation of the immune system could result in improved disease outcomes.

Lifestyle Factors That May Affect Parkinson's Risk

While there is no cure for Parkinson's disease, some lifestyle adjustments may decrease the chances of developing the illness. Since neurodegenerative diseases are associated with chronic inflammation and immune dysfunction, developing habits that enhance immune function might prove helpful.

Diet: There is evidence to suggest that eating in accordance with the Mediterranean or MIND diets, both high in antioxidants, healthy fats, and anti-inflammatory foods, can encourage brain wellness and reduce Parkinson's risk.

Avoiding Dangerous Substances: Restricting alcohol and nicotine use can maintain a robust immune system and suppress inflammation.

Reducing Stress: Chronic stress weakens immune function, so methods such as meditation, exercise, and sufficient sleep can lead to improved overall well-being.

The number of autistic women is same as the number of autistic men, but women know to hide it well, says research. A study published in the BMJ, found that while the rates of diagnosis for autistic is found among young boys and girls, rates are almost identical by the time they reach adulthood. However, these new findings have also shown that women are more likely to "mask" signs of autism in order to fit in. This is why their diagnosis is done far later.

What Did The Study Find Out?

This is the first major study to find such high levels of condition among women. Previously, diagnoses rates were four times higher among boys and men than females.

Specialists say the findings highlight the urgent need to move away from outdated stereotypes that still influence how autism is recognized and diagnosed.

The international study, led by researchers at the Karolinska Institutet in Sweden, examined autism diagnosis rates among people born in Sweden between 1985 and 2000. More than 2.7 million individuals were followed for up to 37 years, making it one of the most comprehensive studies of its kind.

By 2022, around 2.8 per cent of the population studied had been diagnosed with autism spectrum disorder. The data revealed a clear pattern. In early childhood, boys were far more likely than girls to receive an autism diagnosis. However, this gap steadily narrowed during adolescence.

By the time participants reached their late teens and early 20s, diagnosis rates among men and women were broadly similar. Researchers noted that the male to female ratio of autism diagnoses decreased over time to the point that it may no longer be distinguishable in adulthood.

A Catch-Up Effect in Adolescence

Dr Caroline Fyfe, lead author of the study from the University of Edinburgh, said autism has long been viewed as a condition that mainly affects males. While that pattern was still visible in children under 10, the picture changed rapidly during adolescence.

Read: Mattel Launches First-Ever Barbie With Autism

She explained that diagnoses among girls rose sharply in the teenage years, creating what researchers described as a female catch-up effect. By the age of 20, autism rates were almost equal between men and women. According to Dr Fyfe, this suggests late or missed diagnoses in females rather than a true biological difference between sexes.

Masking and Mental Health Misdiagnoses

Experts say one major reason for delayed diagnosis is masking. Girls and women are often more likely to imitate social behavior, maintain eye contact and suppress traits traditionally associated with autism. While this can help them fit in socially, it can also make their difficulties harder to identify in clinical settings.

Dr Judith Brown from the National Autistic Society said gender should never be a barrier to diagnosis or support. She noted that autistic women who are misdiagnosed often develop additional mental health challenges due to years without appropriate understanding or help.

She added that the exhaustion of constant masking can contribute to anxiety and depression, reinforcing the importance of recognizing autism earlier in girls.

Clinical Biases Under Scrutiny

Dr Steven Kapp, senior lecturer in psychology at the University of Portsmouth, said research has consistently shown that clinical biases play a role in under-recognizing autism in women and girls. He explained that subtler behaviors and social adaptation often lead clinicians to overlook autism in females.

A linked editorial written by a patient and advocate echoed these concerns, warning that autistic women are frequently labelled with mood or personality disorders while waiting for a correct diagnosis. As a result, many are forced to self-advocate simply to be recognized as autistic.

Experts say the findings should prompt changes in diagnostic approaches, ensuring that autistic girls and women are no longer left unseen.

Actor Claire Foy has revealed that a long, uncomfortable health struggle picked up while travelling ended up reshaping her relationship with caffeine. The Crown star, 41, said she gave up tea and coffee after discovering she had stomach parasites, an experience she described as “gross” and “absolutely rank.”

Foy shared the story during her appearance on The Table Manners Podcast with hosts Jessie and Lennie Ware on February 4, where the conversation moved from food to a period of unexplained weight loss and constant hunger.

“I kept losing weight, and I didn’t know what was going on,” she told the hosts. Despite eating regularly, she said she never felt full. “I was so hungry,” Foy recalled, adding that the situation left her confused and worried.

Diagnosis After Years of Symptoms

The actor explained that the cause was eventually traced back to stomach parasites she had picked up while travelling in Morocco. The diagnosis came after medical tests, including stool samples, which she candidly described as unpleasant but necessary.

According to Foy, doctors told her she had been carrying the parasites for around five years, a length of time she herself described as “quite a long time.” While she did not name the specific parasites, she shared one detail that stuck with her. “They travel as a pair, I got told by the doctor,” she said, reacting with visible disgust even years later.

Living with the condition took a toll on her body and routine. The ongoing symptoms pushed her to rethink how she approached treatment and daily habits, including what she consumed.

Read: 10 Signs You May Have A Parasite

Clair Foy Had Parasites For 5 Years: Why Caffeine Had to Go

It was during treatment that Foy made the decision to give up caffeine entirely. She explained that she wanted to avoid very strong antibiotics if possible and instead followed a strict diet alongside other treatments. “I basically had to go on this diet,” she said. “I didn’t want to take really hardcore antibiotics.”

As part of that process, caffeine was cut out. “I took all this gross stuff and part of that was giving up caffeine,” Foy told the hosts. At the time, it was a major shift. She admitted she had been a heavy caffeine consumer, drinking around 15 cups of tea a day along with two coffees she had carefully planned into her schedule.

A Habit That Never Came Back

Giving up caffeine was not easy, but once she did, Foy decided to stick with it. “Once you’ve given it up, it’s such a mission to give it up, that I was like, well, maybe I’ll just give it a go,” she said.

Now fully caffeine-free, she even brought her own tea bags to the podcast recording. The show is known for hosts and guests sharing food and drinks in the Ware family kitchen, making her preparation a small but telling detail of how seriously she takes the change.

Medical experts note that parasitic infections usually require medication to clear completely, often involving antiparasitic drugs and sometimes antibiotics or antifungals. In many cases, a combination of treatments is needed.

"I went into chemo-induced menopause at 37," said Lisa Ray, a Canadian actress during an interview with BBC. She also shared the clip of the interview on her Instagram account talking about the importance of awareness about the side effects of cancer and its treatment on women. Sharing the clip on her Instagram story, she wrote "This is me in menopause. Menopause does not have one face...I went into premature chemo-induced menopause at 37."

She revealed that she had blood cancer, called Multiple Myeloma. "At that time, it was the least of my worries. I had a blood cancer called Multiple Myeloma to contend with… But after recovering, I could focus on what being in menopause suddenly at 37 would mean. And I had no one to talk to," said Lisa, now 53.

What Is Chemo-induced Menopause?

Chemotherapy do not just target cancer cells, but it can also harm healthy cells, which are fast diving. Ovaries fall into that category and thus they stop producing hormones like estrogen and progesterone, which pushes the body into sudden menopause.

This condition is called iatrogenic menopause or chemotherapy-induced ovarian failure. While it could be temporary for some people, for others, it could be permanent. Experts explain that women under 30 could see their periods return after the treatment.

Chemotherapy works by attacking cells that grow and divide rapidly. While this helps destroy cancer cells, it also affects healthy cells, such as those responsible for hair growth, which is why hair loss is a common side effect.

This process can also impact reproductive organs, including the ovaries, and disrupt hormone production. As a result, levels of estrogen and progesterone—the key hormones involved in menopause—may become imbalanced due to chemotherapy’s effects on the endocrine system.

Damage to cells and these hormonal shifts can trigger menopausal symptoms and, in some cases, cause periods to stop altogether.

For people over 40, hormone levels may already be naturally declining. In such cases, chemotherapy can accelerate a menopausal transition that has already begun.

Chemo-induced Menopause Symptoms

The symptoms are same as one experiences in natural menopause, which include:

• Hot flashes
• Night sweats
• Mood swings
• Fatigue
• Vaginal dryness
• Loss of libido

However, Lisa also points out the emotional impact, which could be intense especially for someone who is young and was not expecting to face menopause for decades. “Both menopause and disease-induced menopause have been treated with shame and silence for too long,” Lisa wrote on her Instagram post.

Chemo-induced Menopause: What Can Help?

Hormone Replacement Therapy (HRT): When considered safe and not restricted by hormone-sensitive cancers, HRT can help manage symptoms while supporting bone strength and heart health.

Non-hormonal treatments: Certain medications, including SSRIs, SNRIs, and gabapentin, may reduce hot flashes, while vaginal moisturizers and lubricants can relieve dryness.

Lifestyle changes: Staying physically active, following a calcium and vitamin D-rich diet, maintaining a healthy weight, and managing stress can significantly support overall wellbeing.

Fertility support: Options such as egg or embryo freezing before treatment, along with consultations with a fertility specialist afterward, may help preserve future parenthood possibilities.