The COVID-19 pandemic may be over, but our immune systems are still feeling the impact. After years of battling constant viral threats, from COVID-19 to seasonal flu and other infections, our body’s defense system is exhausted. Many people continue to experience lingering inflammation, frequent illnesses, and slower recovery times. This extended state of immune stress has compromised us further to chronic illness, including autoimmune diseases and even neurodegenerative diseases such as Parkinson's. So why is our immune system still in trouble? And how do we give it its power back? Understanding immune exhaustion is the beginning of rebuilding our body's natural immunity.

A weakened immune system makes people more susceptible to disease, mental illnesses, and even sleep disorders. Now, new research indicates that immune system depletion may play an important role in the onset of Parkinson's disease, a degenerative neurologic disorder that compromises movement and cognition.

Role of Inflammation in Parkinson's Disease

Dysfunctional immune response is a leading cause of long-standing inflammation within the body, that has been found to contribute towards a multitude of conditions, including cardiovascular conditions, diabetes, depression, and neurodegenerative diseases such as Alzheimer's.

As people age, their immune system naturally becomes less effective. This deterioration, referred to as immune exhaustion, may be a key contributor to the onset and progression of Parkinson’s disease. Rebecca Wallings, a Parkinson’s Foundation Launch Award grant recipient and senior postdoctoral fellow at the University of Florida, believes that an accumulation of exhausted immune cells could be driving neurodegeneration in Parkinson’s patients.

How a Tired Immune System Might Affect Parkinson's?

Parkinson's disease is most commonly linked with the degeneration and loss of dopaminergic neurons—motor nerve cells that produce dopamine, an essential neurotransmitter for movement. While researchers have long suspected inflammation is involved in this neurodegeneration, the mechanisms are not yet well understood.

Wallings' study is on immune cell exhaustion, a process by which aging immune cells fail to control immune responses effectively. Her research indicates that instead of dampening inflammation in Parkinson's patients, attempts should be made to rejuvenate the immune system to regain its functionality.

Energy Deficiency in Immune Cells

One of the major findings of Wallings' work is the function of mitochondrial impairment in immune cell exhaustion. Mitochondria are commonly called the powerhouses of cells, as they are vital for generating energy. As mitochondria age and become inefficient, immune cells fail to function well, potentially accelerating neurodegeneration in Parkinson's disease.

Wallings has found that mutations in the LRRK2 gene, a recognized genetic risk factor for Parkinson's disease, are linked with defective mitochondrial function and immune cell exhaustion. Her current work includes testing various therapeutic approaches to restore mitochondrial function in immune cells with the potential to enhance the immune system and potentially prevent or treat Parkinson's disease.

Will Rejuvenating the Immune System Help in Treatment?

For decades, the standard practice in treating Parkinson's has been to suppress brain inflammation. Yet Wallings' work indicates that instead of slowing down immune responses, restoring the immune system could be a more successful strategy. By addressing mitochondrial impairment and immune resilience, researchers can potentially reverse or slow down Parkinson's disease.

Wallings is now looking into how to rejuvenate immune cells by fixing mitochondria. She studies immune cells from patients with Parkinson's as well as from healthy subjects and performs experiments on animal models to determine if rejuvenation of the immune system could result in improved disease outcomes.

Lifestyle Factors That May Affect Parkinson's Risk

While there is no cure for Parkinson's disease, some lifestyle adjustments may decrease the chances of developing the illness. Since neurodegenerative diseases are associated with chronic inflammation and immune dysfunction, developing habits that enhance immune function might prove helpful.

Diet: There is evidence to suggest that eating in accordance with the Mediterranean or MIND diets, both high in antioxidants, healthy fats, and anti-inflammatory foods, can encourage brain wellness and reduce Parkinson's risk.

Avoiding Dangerous Substances: Restricting alcohol and nicotine use can maintain a robust immune system and suppress inflammation.

Reducing Stress: Chronic stress weakens immune function, so methods such as meditation, exercise, and sufficient sleep can lead to improved overall well-being.

Irritable Bowel Syndrome (IBS) is becoming an increasingly important health issue among IT professionals, who are specifically at risk because of certain factors present in corporate culture. There has been a gradual rise in the prevalence of IBS among these individuals over the last ten years, due not only to better diagnosis but also to the accumulation of stress, erratic lifestyles, and physical inactivity.

What is contributing to IBS cases in the IT industry?

Dr Sudha Subhana Desai, Senior Consultant in Internal Medicine and Critical Care at Ruby Hall Clinic, Pune, said, "The first factor contributing to the development of IBS in the IT environment is constant psychological stress. Working in the information technology industry requires the ability to meet tight deadlines, maintain high-level performance, and spend many hours in front of a computer while coordinating with colleagues from different time zones. All these activities affect normal circadian rhythms, placing an individual's body under constant stress. This becomes particularly relevant as the connection between the central nervous system and the digestive tract via the gut-brain axis is involved in this mechanism. Thus, constant stress can lead to disturbances in gut motility, increased sensitisation, and an imbalance of the flora. Hence, individuals develop common IBS symptoms such as abdominal pain, bloating, constipation, diarrhoea, or an alternation between these."

How do dietary habits of IT professionals worsen IBS?

Further, Dr Desai spoke about how the dietary practices common among employees in IT professions exacerbate the issue. The expert said that the hectic nature of their work schedules often forces them to resort to unhealthy eating practices, including eating out at fast food restaurants. Their diet often consists of foods lacking dietary fibre but containing high levels of fats, sugars, and additives. This is unhealthy not only because it is nutritionally unbalanced but also because such foods may cause gastrointestinal problems. In addition, their unpredictable work hours make their diet and sleep habits less regular, thus disrupting digestive processes.

The role of lifestyle habits in IBS risk

Other lifestyle behaviours typical of employees in IT professions put them at higher risk. Firstly, a lack of exercise, which results from long working days, prolonged sitting, and little physical activity, slows down intestinal motility and decreases overall metabolism. Secondly, long screen exposure and sedentary behaviour have the same effect. Thirdly, poor sleep quality, experienced by night shift workers and those responsible for international projects, adversely impacts the hormonal balance necessary for healthy digestion. Lastly, high caffeine intake is typical of these employees, as they use coffee and energy drinks to alleviate fatigue.

While there is increased health consciousness, along with improved availability of medical care, the increase in IBS can only be partially explained by increased diagnoses. Rather, there is an actual increase due to stress factors and living patterns associated with the working environment of the IT industry.

Treating IBS among IT professionals

In the treatment of IBS among IT professionals, a number of factors must be addressed in order to help individuals cope with their conditions. One such factor is stress management. Professionals must be taught various methods of coping with stress, ranging from exercises such as yoga and breathing techniques to more structured interventions. The environment must also be conducive to health and well-being. In other words, organisations must facilitate a healthy working environment and encourage individuals to achieve a work-life balance while reducing any workload stresses. Professionals must also make alterations to their dietary habits, including eating regularly, having fibre-rich meals, and avoiding highly processed foods.

Iron deficiency, or anaemia, is a common occurrence these days, especially in women. However, a study’s findings will make you stop normalising low iron levels—it turns out that anaemic people are more likely to develop dementia later in life. Experts have long warned about low iron levels and advised rectifying the condition as soon as it is diagnosed. Swedish scientists have recently found that anaemic people are 60 per cent more likely to develop dementia later in life.

How does iron deficiency raise dementia risk later?

Writing in the journal JAMA Network Open, scientists noted that dangerously low levels of iron can dramatically raise the risk of dementia in old age. Research suggests that people who are severely anaemic are more likely to face problems with thinking, understanding, and memory later in life. For this, Swedish researchers tracked thousands of people aged 60 years and above for about a decade and discovered that people living with anaemia were 60 per cent more likely to develop dementia later in life.

Researchers said that the findings were important for understanding that anaemia could also qualify as a risk factor for dementia, apart from family history. However, the study does not conclusively prove that anaemia triggers dementia later in life. Experts from theKarolinska Institute said that anaemia patients exhibit a higher risk of dementia, along with elevated levels of Alzheimer’s-related blood biomarkers. The findings, therefore, suggest that anaemia is a relevant factor to consider in dementia prevention strategies.

Study’s findings explained

In the study, researchers tracked 2,282 volunteers aged 60 years and above who showed no symptoms of dementia. Blood samples were also analysed to check for levels of tau, a toxic protein that spreads in the brain. Experts found that clumps of this protein and amyloid can form tangles in the brain, thereby resulting in Alzheimer’s-like symptoms.

Are men more prone to anaemia-related dementia?

While evaluating blood samples for haemoglobin levels to diagnose anaemia, researchers followed up for over nine years and found that 362 of the participants had developed the condition. Compared to people with normal haemoglobin levels, anaemic people had higher levels of tau. During the follow-up period, anaemic people were 66 per cent more likely to develop dementia. Experts also noted that anaemia was associated with a higher risk of dementia in men compared to women, despite anaemia being a concern more often for women. This could be because, in men, anaemia is often driven by inflammation or chronic diseases.

What is anaemia?

Anaemia is a condition characterised by iron deficiency—in this condition, the number of red blood cells or haemoglobin is lower than normal. Iron is essential for the creation of red blood cells that help transport oxygen in the body. The symptoms of anaemia include palpitations, shortness of breath, or pale skin. Other symptoms include hair loss, mouth ulcers, or tinnitus.

What triggers anaemia?

Sometimes, anaemia can be triggered by excessive bleeding during periods or bleeding in the intestines or stomach. Overuse of anti-inflammatory drugs can also trigger the condition. Doctors say that eating iron-rich foods like leafy greens, red meat, and lentils can boost iron levels in the body.

Did you know? Discontinuing activities and overly restrictive behaviour, including unnecessary bed rest, does not improve implantation chances when it comes to IVF. Instead, balanced living, moderate activity, proper nutrition, and emotional well-being are important after the procedure. Hence, make sure to follow the advice given by a fertility consultant. Women should prioritise their health.

A failed IVF attempt is not just a financial crisis but also an emotional rollercoaster. For several couples struggling with infertility, IVF offers a ray of hope and may even help them conceive a baby. However, sometimes the attempt can fail due to several reasons, but do not let that affect your motivation to engage in your favourite activities.

Dr Rashmi Agarwal, Fertility Specialist, Nova IVF Fertility, Gurugram, in an interview with Health and Me, spoke about the rising incidence of infertility in young couples, and how following a restricted behaviour may only lower the odds of conceiving a baby.

How is IVF coming to the rescue of young couples?

Infertility cases are rising among couples. There are a large number of couples who struggle with infertility and opt for in vitro fertilisation (IVF). However, couples tend to have doubts regarding it. For those who undergo IVF, the period after embryo transfer is filled with hope, anxiety, and a strong urge to “do everything right”. Many women feel that after the procedure, complete bed rest, taking it easy, and avoiding any activity can increase the chances of pregnancy. However, maintaining a balanced routine is often more beneficial than extreme rest.

What happens after an embryo transfer

After embryo transfer, many patients assume that movement could disturb implantation, and they suddenly avoid all activities without asking the doctor. They try not to walk, work, or do any household chores. But do not worry or panic, as the embryo is safely placed inside the uterus and cannot “fall out” with normal movement. The body is naturally designed to support implantation. There is no evidence available that claims that strict bed rest improves success rates. However, staying inactive for long periods can lead to stiffness, poor blood circulation, and increased stress or anxiety, which can take a toll on overall well-being.

How to improve chances of IVF success

Light activities like walking, gentle stretching, and routine household tasks are generally safe, as recommended by the doctor. Eating a nutritious diet, staying hydrated by drinking 3–4 litres of water per day, de-stressing by doing meditation or reading, and getting enough sleep can be beneficial for women. Many women can also overthink, become anxious, and constantly worry about pregnancy. Hence, opting for relaxing activities like deep breathing, meditation, reading, staying connected with loved ones, and maintaining a positive mindset can help patients cope better during the waiting period, although it is not advised to overexert or do any strenuous activities without the doctor’s knowledge.

Following the expert’s instructions without fail, staying active, doing light exercises, and paying attention to physical and emotional well-being can support a smoother IVF journey.