The COVID-19 pandemic may be over, but our immune systems are still feeling the impact. After years of battling constant viral threats, from COVID-19 to seasonal flu and other infections, our body’s defense system is exhausted. Many people continue to experience lingering inflammation, frequent illnesses, and slower recovery times. This extended state of immune stress has compromised us further to chronic illness, including autoimmune diseases and even neurodegenerative diseases such as Parkinson's. So why is our immune system still in trouble? And how do we give it its power back? Understanding immune exhaustion is the beginning of rebuilding our body's natural immunity.

A weakened immune system makes people more susceptible to disease, mental illnesses, and even sleep disorders. Now, new research indicates that immune system depletion may play an important role in the onset of Parkinson's disease, a degenerative neurologic disorder that compromises movement and cognition.

Role of Inflammation in Parkinson's Disease

Dysfunctional immune response is a leading cause of long-standing inflammation within the body, that has been found to contribute towards a multitude of conditions, including cardiovascular conditions, diabetes, depression, and neurodegenerative diseases such as Alzheimer's.

As people age, their immune system naturally becomes less effective. This deterioration, referred to as immune exhaustion, may be a key contributor to the onset and progression of Parkinson’s disease. Rebecca Wallings, a Parkinson’s Foundation Launch Award grant recipient and senior postdoctoral fellow at the University of Florida, believes that an accumulation of exhausted immune cells could be driving neurodegeneration in Parkinson’s patients.

How a Tired Immune System Might Affect Parkinson's?

Parkinson's disease is most commonly linked with the degeneration and loss of dopaminergic neurons—motor nerve cells that produce dopamine, an essential neurotransmitter for movement. While researchers have long suspected inflammation is involved in this neurodegeneration, the mechanisms are not yet well understood.

Wallings' study is on immune cell exhaustion, a process by which aging immune cells fail to control immune responses effectively. Her research indicates that instead of dampening inflammation in Parkinson's patients, attempts should be made to rejuvenate the immune system to regain its functionality.

Energy Deficiency in Immune Cells

One of the major findings of Wallings' work is the function of mitochondrial impairment in immune cell exhaustion. Mitochondria are commonly called the powerhouses of cells, as they are vital for generating energy. As mitochondria age and become inefficient, immune cells fail to function well, potentially accelerating neurodegeneration in Parkinson's disease.

Wallings has found that mutations in the LRRK2 gene, a recognized genetic risk factor for Parkinson's disease, are linked with defective mitochondrial function and immune cell exhaustion. Her current work includes testing various therapeutic approaches to restore mitochondrial function in immune cells with the potential to enhance the immune system and potentially prevent or treat Parkinson's disease.

Will Rejuvenating the Immune System Help in Treatment?

For decades, the standard practice in treating Parkinson's has been to suppress brain inflammation. Yet Wallings' work indicates that instead of slowing down immune responses, restoring the immune system could be a more successful strategy. By addressing mitochondrial impairment and immune resilience, researchers can potentially reverse or slow down Parkinson's disease.

Wallings is now looking into how to rejuvenate immune cells by fixing mitochondria. She studies immune cells from patients with Parkinson's as well as from healthy subjects and performs experiments on animal models to determine if rejuvenation of the immune system could result in improved disease outcomes.

Lifestyle Factors That May Affect Parkinson's Risk

While there is no cure for Parkinson's disease, some lifestyle adjustments may decrease the chances of developing the illness. Since neurodegenerative diseases are associated with chronic inflammation and immune dysfunction, developing habits that enhance immune function might prove helpful.

Diet: There is evidence to suggest that eating in accordance with the Mediterranean or MIND diets, both high in antioxidants, healthy fats, and anti-inflammatory foods, can encourage brain wellness and reduce Parkinson's risk.

Avoiding Dangerous Substances: Restricting alcohol and nicotine use can maintain a robust immune system and suppress inflammation.

Reducing Stress: Chronic stress weakens immune function, so methods such as meditation, exercise, and sufficient sleep can lead to improved overall well-being.

US tech giant Apple today announced that Tim Cook has been elevated to executive chairman of the company and will step down as CEO.

John Ternus, senior vice president of hardware engineering, will succeed Cook as chief executive officer, effective September 1, 2026.

“It has been the greatest privilege of my life to be the CEO of Apple,” Cook said in an official statement, praising Ternus as someone with “the mind of an engineer, the soul of an innovator, and the heart to lead with integrity.”

Apple’s Biggest Contribution In Health: Tim Cook

Cook has led Apple since 2011, after the passing of co-founder Steve Jobs. Under Cook, the company shifted from a device company to a consumer health platform company.

“If you zoom out way into the future, and you look back and ask what Apple’s biggest contribution was, it will be in the health area,” Cook said in an interview with WIRED, an American magazine, in 2024.

The company entered the wearables segment with the Apple Watch in 2015. From being a fashion statement, it gradually evolved into a health-focused product.

Under Cook’s leadership, Apple moved from wellness tracking to proactive medical monitoring, with the Apple Watch at its core.

With features ranging from ECG to blood oxygen monitoring and fall detection, it expanded Apple’s ecosystem beyond smartphones.

Cook focused on “democratizing” healthcare by empowering users to track metrics such as AFib, sleep apnea, hypertension, and blood oxygen levels.

Here's a look at various features of Apple devices under Tim Cook that focused on health, ranging from heart to vision to reproductive health.

Heart Health

With advanced features like hypertension notifications, irregular rhythm notifications, the ECG app, and AFib history, the Apple Watch provides users with an invaluable view of their cardiovascular health.

Apple Watch can detect patterns of hypertension that may increase the risk of heart attack, stroke, and kidney disease.

It works by using the optical heart sensor, which provides data to an algorithm that can detect potential hypertension by analysing how blood vessels respond to heartbeats over 30-day periods.

Key features include:

• AirPods Pro 3 come with heart rate sensing, helping users track heart rate and calories burned during workouts. Using LEDs that pulse invisible light 256 times per second, along with sensor fusion from accelerometers, users can get highly accurate data across up to 50 workout types in the Fitness app.

• Apple Watch can measure VO₂ max -- the maximum amount of oxygen the body can consume during exercise.
• If cardio fitness levels are low for age and sex, users receive a notification. Fitness can be improved by increasing the intensity and frequency of cardiovascular exercise.

Hearing Health

The Noise app on Apple Watch sends notifications when environmental noise levels may affect hearing health.

Apple’s AirPods Pro also provide loud sound reduction, lowering sound exposure in environments as loud as 110 dBA.

The Sleep and Activity Tracker

The device tracks sleep, which plays a crucial role in physical and mental health. Apple Watch can monitor sleep and provide a daily sleep score.

Apple Watch Activity Rings enables customizable goals that encourages consistent physical activity. It also provides a daily visual representation of movement through metrics such as:

• move (red, active calories),
• exercise (green, minutes of brisk activity),
• stand (blue, hours with at least one minute of movement).

The Apple Watch Workout app features enhanced training load tracking, custom workout builders for strength training, and new metrics for personalized fitness tracking.

Even without an Apple Watch, users can set a daily Move goal in the Fitness app on iPhone to stay motivated. It tracks steps, distance, flights climbed, and workouts from third-party apps to estimate active calories contributing to the Move goal.

Also read: India Introduces Healthy Lifestyle, Mental Wellness as Priority Areas at BRICS Meet

Period Tracking And Reproductive Health

The Cycle Tracking experience on iPhone, Apple Watch, and iPad allows users to log periods and record symptoms or cycle factors for a better understanding of their cycle. It helps with family planning by tracking temperature during sleep and estimating when ovulation likely occurred. Wrist temperature can also improve period predictions.

It also flags for deviations such as irregular, infrequent, or prolonged periods, or persistent spotting.

Further, in the Health app on iPhone or iPad, Cycle Tracking offers additional support during pregnancy, including gestational age tracking and health chart monitoring. It also reminds users to check in on mental health conditions during pregnancy and postpartum periods.

Eye Health

iPhone, iPad, and Apple Watch include features designed to support eye health, especially myopia or nearsightedness in children.

The Screen Distance feature on iPhone and iPad uses the TrueDepth camera (also used for Face ID) to detect when a device is held closer than 30.48 cm (12 inches) for extended periods and encourages users to move it farther away.

Users can also store their vision prescription in the Health app. It can be securely saved on iPhone and iPad by taking a photo of the document or entering the details manually.

The first national mental health survey carried out in India, 2015-2016, suggested that one in 10 Indians had a diagnosable psychiatric disorder.

Following the COVID-19 pandemic, there was a surge in common mental disorders (particularly anxiety and depression). Worldwide, the age of onset of substance use disorders is reducing, and there has been an increase in synthetic and pharmaceutical drug misuse.

Digital addiction is a growing problem, particularly among young people. Suicide is a major global concern, and in India, there were more than two lakh suicides in 2025. Rising suicides in urban areas and among students have been growing concerns.

Improving Mental Health Literacy

Just like people recognize physical disorders, it is important to improve mental health literacy so that people can recognize symptoms of a mental or psychiatric disorder in themselves or others. It is also important that they reach out for timely help, without a sense of feeling stigmatized.

Often, physical and mental disorders occur together and worsen each other, so addressing both is important to improve health outcomes.

How Government Is Tackling Mental Health Burden

The Government of India has initiated the Tele MANAS (14416) to provide telephonic mental health counselling and to link people up to other services. The National Mental Health Program of India seeks to provide decentralized mental health care at the District levels and below.

The Ayushman Arogya Mandirs also offer basic mental health support. NIMHANS, apart from providing quality institution-based services, has also been closely involved in developing community models of mental health care, working with non-governmental organizations and with community stakeholders. It has also been focusing on expanding human resources through its digital academy.

A second NIMHANS in northern India, strengthening some of the other institutions providing mental health care to expand infrastructure, human resources, and networking to develop a continuum of care from primary to tertiary care settings, is a recent step taken by the Union government.

Urological cancer cases are surging at an alarming rate in India. Yet, many patients continue to seek medical help only when the disease has reached an advanced stage. Doctors highlight that cancers affecting the urinary system are often silent during the initial stages and are ignored by people owing to a lack of awareness and hesitation in consulting an expert. It is important to remember that timely urology screening can help detect cancer early, reduce complications, and improve survival rates. Many people ignore symptoms and seek help only during the advanced stages, when the risk of complications also increases. Experts are urging people, especially those at higher risk, to seek early screening and intervention without delay.

What are urological cancers?

“People should prioritise their well-being and seek timely help,” said Dr Pradeep Rao, Head of Department – Urology Oncoscience, Gleneagles Hospital, Mumbai.

Diagnosis and treatment of urological cancers

Dr Pradeep Rao further explained how early-stage urological cancers are often treatable with less aggressive procedures, while advanced cancers require complex treatment and carry higher risks. Diagnosis is carried out through urine examination, ultrasound, and prostate-specific antigen (PSA) testing to detect cancer early. Timely screening and intervention can not only save lives but also preserve organ function. Advanced techniques such as robotic-assisted surgery are now widely used to provide relief to patients. Robotics has made diagnosis, treatment, and the healing journey much smoother for both patients and doctors.

What are the symptoms of urological cancers?

“Urological cancers such as prostate, bladder, and kidney cancer are rising across age groups, yet many patients seek medical help only when symptoms become severe. Each month, two to three patients in the age group of 30–65 consult me when symptoms worsen and the cancer progresses, which takes a toll on their overall well-being. Moreover, signs and symptoms such as blood in the urine, difficulty in urination, pelvic pain, or unexplained weight loss are often ignored, leading to advanced-stage disease that can cause anxiety and panic among patients. Delayed diagnosis can result in serious complications such as kidney damage, the spread of cancer, and reduced quality of life. Early screening and treatment are life-saving. Currently, a combination of robotic surgery, chemotherapy, radiation therapy, and targeted treatments offers better outcomes, but early diagnosis remains the most critical factor for successful recovery,” concluded Dr Anil Bradoo, Consultant Urologist, Zen Annexe, Zen Multispeciality Hospital, Chembur, Mumbai.

What are the benefits of robotic surgeries?

Dr Pradeep Rao also explained the benefits of robotic surgeries. Robotic-assisted prostatectomy for prostate cancer helps with the accurate removal of the prostate while protecting vital nerves, thereby reducing the risk of incontinence and erectile dysfunction. Robotic partial nephrectomy is performed for kidney cancer and helps remove diseased kidney tissue while preserving the kidney, with minimal blood loss and quicker healing. The advantages of robotic surgery include precise tumour removal with minimal blood loss, reduced pain and complications, shorter hospital stays, and faster recovery. Early-stage patients benefit the most from these modern treatments, which is why awareness and screening are so important.