The COVID-19 pandemic may be over, but our immune systems are still feeling the impact. After years of battling constant viral threats, from COVID-19 to seasonal flu and other infections, our body’s defense system is exhausted. Many people continue to experience lingering inflammation, frequent illnesses, and slower recovery times. This extended state of immune stress has compromised us further to chronic illness, including autoimmune diseases and even neurodegenerative diseases such as Parkinson's. So why is our immune system still in trouble? And how do we give it its power back? Understanding immune exhaustion is the beginning of rebuilding our body's natural immunity.

A weakened immune system makes people more susceptible to disease, mental illnesses, and even sleep disorders. Now, new research indicates that immune system depletion may play an important role in the onset of Parkinson's disease, a degenerative neurologic disorder that compromises movement and cognition.

Role of Inflammation in Parkinson's Disease

Dysfunctional immune response is a leading cause of long-standing inflammation within the body, that has been found to contribute towards a multitude of conditions, including cardiovascular conditions, diabetes, depression, and neurodegenerative diseases such as Alzheimer's.

As people age, their immune system naturally becomes less effective. This deterioration, referred to as immune exhaustion, may be a key contributor to the onset and progression of Parkinson’s disease. Rebecca Wallings, a Parkinson’s Foundation Launch Award grant recipient and senior postdoctoral fellow at the University of Florida, believes that an accumulation of exhausted immune cells could be driving neurodegeneration in Parkinson’s patients.

How a Tired Immune System Might Affect Parkinson's?

Parkinson's disease is most commonly linked with the degeneration and loss of dopaminergic neurons—motor nerve cells that produce dopamine, an essential neurotransmitter for movement. While researchers have long suspected inflammation is involved in this neurodegeneration, the mechanisms are not yet well understood.

Wallings' study is on immune cell exhaustion, a process by which aging immune cells fail to control immune responses effectively. Her research indicates that instead of dampening inflammation in Parkinson's patients, attempts should be made to rejuvenate the immune system to regain its functionality.

Energy Deficiency in Immune Cells

One of the major findings of Wallings' work is the function of mitochondrial impairment in immune cell exhaustion. Mitochondria are commonly called the powerhouses of cells, as they are vital for generating energy. As mitochondria age and become inefficient, immune cells fail to function well, potentially accelerating neurodegeneration in Parkinson's disease.

Wallings has found that mutations in the LRRK2 gene, a recognized genetic risk factor for Parkinson's disease, are linked with defective mitochondrial function and immune cell exhaustion. Her current work includes testing various therapeutic approaches to restore mitochondrial function in immune cells with the potential to enhance the immune system and potentially prevent or treat Parkinson's disease.

Will Rejuvenating the Immune System Help in Treatment?

For decades, the standard practice in treating Parkinson's has been to suppress brain inflammation. Yet Wallings' work indicates that instead of slowing down immune responses, restoring the immune system could be a more successful strategy. By addressing mitochondrial impairment and immune resilience, researchers can potentially reverse or slow down Parkinson's disease.

Wallings is now looking into how to rejuvenate immune cells by fixing mitochondria. She studies immune cells from patients with Parkinson's as well as from healthy subjects and performs experiments on animal models to determine if rejuvenation of the immune system could result in improved disease outcomes.

Lifestyle Factors That May Affect Parkinson's Risk

While there is no cure for Parkinson's disease, some lifestyle adjustments may decrease the chances of developing the illness. Since neurodegenerative diseases are associated with chronic inflammation and immune dysfunction, developing habits that enhance immune function might prove helpful.

Diet: There is evidence to suggest that eating in accordance with the Mediterranean or MIND diets, both high in antioxidants, healthy fats, and anti-inflammatory foods, can encourage brain wellness and reduce Parkinson's risk.

Avoiding Dangerous Substances: Restricting alcohol and nicotine use can maintain a robust immune system and suppress inflammation.

Reducing Stress: Chronic stress weakens immune function, so methods such as meditation, exercise, and sufficient sleep can lead to improved overall well-being.

After eliminating measles in 2000, the US is now seeing a sharp increase in cases, with 3,659 confirmed cases reported as of September 24, 2026. Pennsylvania has reported five measles-related deaths this year, the first such deaths in the state in 35 years.

The number has risen significantly from previous years. The US reported 2,289 cases in 2025, compared with 285 in 2024 and just 85 cases in 2000.

Measles can cause serious complications, including pneumonia and encephalitis, or brain swelling, and can be fatal.

Two doses of the measles, mumps and rubella (MMR) vaccine can prevent measles by up to 97%, although breakthrough infections can still occur.

Around 95% of reported cases have been among unvaccinated people, although breakthrough infections have also been reported among people who were fully vaccinated. However, measles is not expected to be as severe in people who are vaccinated.

“Their illness will be much more mild and less likely to cause serious illness than if they had not received two vaccines,” Dr. Pia Fenimore, chief and vice chair of pediatrics at Penn Medicine Lancaster General Health.

Yet according to experts some people can take a booster shot to stay safe.

Who May Need a Measles Booster?

The first measles vaccine was introduced in the US in 1963, but the formulation used between 1963 and 1967 was less effective than current versions.

Adults vaccinated during that period may need another dose if they have not received a later measles vaccine.

People born before 1957 are generally considered to have presumptive evidence of immunity because measles circulated widely before routine vaccination, and most people in this age group were naturally infected.

Some people may need individualized vaccination guidance rather than standard recommendations, including:

• People with uncertain vaccination status or no vaccination records
• People who received an inactivated measles vaccine between 1963 and 1967
• People with a weakened immune system
• Pregnant people

A measles vaccine booster may also be considered for children who received only one MMR dose, high-risk adults such as healthcare workers or international travelers, and people whose testing shows they lack immunity.

Can A Blood Test Check Measles Immunity?

In cases where people do not remember or have no records of two-dose measles vaccination, an Immunoglobulin G (IgG) antibody test can help assess whether they have antibodies against measles.

If testing shows sufficient measles IgG antibodies, the person is considered immune. If immunity is not established, vaccination may be recommended based on their individual circumstances.

Why Adults Also Need To Be Alert

Measles is often associated with children, but adults can also become infected.

“We often forget about adults getting measles ... 38% to 40% of cases this year of measles have been in adults. Adults become infected at the same, if not higher, rates than children themselves ... in 2025, just over half of the measles hospitalizations were actually ... adults,” Dr. Gavin Harris, an infectious diseases physician with Emory Healthcare in Georgia and the associate medical director of the Serious Communicable Diseases Unit.

What If You Were Exposed To Measles?

Measles is highly contagious and can spread through even limited exposure to the virus. With the virus outbreak, it is likely for people to get exposed to it.

The measles vaccine remains the absolute best way to prevent disease.

A shot within three days of exposure to the contagious virus can help prevent the disease. Intravenous immunoglobulin (IVIG) given within six days can also provide protection after exposure.

A 30-year-old law student with Type 1 diabetes was hospitalized with diabetic ketoacidosis (DKA) after allegedly being advised to stop insulin while following the “VRK Diet” promoted by social media personality Veeramachineni Ramakrishna, popularly known as VRK.

According to the complaint, the student had been living with Type 1 diabetes since 2018. He alleged that he came across VRK’s social media videos claiming that the diet could permanently cure conditions including Type 1 diabetes, cancer and kidney disease.

The student later visited the VRK Health Care Centre in Hyderabad in September 2025, where he alleged that he was orally advised to stop taking insulin. He said he paid around ₹26,000 for supplements and services at the center.

Two days later, he was admitted to a private hospital with DKA and severe dehydration, according to the complaint. He was later discharged.

Hyderabad police have booked Ramakrishna and another person in an alleged fake-doctor and fraud case.

Why Type 1 Diabetes Patients Must Never Stop Insulin

Also read: Gut Microbiome Linked To 3x Higher Type 1 Diabetes Risk In Children

More than 9 million people worldwide are estimated to be living with Type 1 diabetes, including about 1.8 million children and adolescents.

Type 1 diabetes occurs when the body cannot produce insulin. Insulin helps glucose move from the blood into cells, where it is used for energy. People with Type 1 diabetes therefore need insulin to control their blood glucose.

“Insulin is not optional in Type 1 diabetes,” Dr Sudhir Kumar, neurologist at Apollo Hospitals, Hyderabad, said in a post on X.

He advised people with Type 1 diabetes to never stop insulin on their own, including when they are unwell or unable to eat.

“Insulin doses may sometimes need adjustment, but this should be done with guidance from your diabetes team,” he said.

What Happens If Insulin Is Stopped?

The NHS UK explains that the human body needs insulin to break down glucose, i.e. sugar, to turn it into energy. People who have type 1 diabetes need insulin devices as their own body cannot produce it.

When the body does not have enough insulin, it cannot properly use glucose for energy. It starts breaking down fat instead, producing chemicals called ketones.

If ketones build up in the blood, they can cause diabetic ketoacidosis, a serious and potentially life-threatening complication.

DKA can develop when there is too little insulin, including when a person with Type 1 diabetes misses insulin doses.

Dr Kumar advised people with Type 1 diabetes to regularly monitor their blood glucose and check blood or urine ketones when indicated, particularly during illness or persistent high blood sugar.

Also read: H. pylori, HPV Among Five Infections Behind 1 In 8 Cancers Worldwide: Lancet

Warning Signs Of Diabetic Ketoacidosis

Dr Kumar said people with Type 1 diabetes should know the warning signs of DKA, including:

• Excessive thirst
• Frequent urination
• Nausea or vomiting
• Abdominal pain
• Dehydration
• Rapid or deep breathing
• Drowsiness or confusion

Anyone with symptoms suggestive of DKA should seek urgent medical care.

Can Diet Or Supplements Replace Insulin?

Type 1 diabetes is an incurable condition. Dr Kumar warned people to be extremely cautious about claims that Type 1 diabetes can be “cured” through supplements, diets, herbs or alternative treatments that allow insulin to be stopped.

“Check the qualifications and registration of anyone giving medical advice. Social-media popularity is NOT a substitute for medical training,” he said.

“One wrong piece of advice can have life-threatening consequences. For Type 1 diabetes, evidence-based medical care and uninterrupted access to insulin are essential,” he added.

Climate change is increasingly affecting human health, with the skin potentially among the first organs to show its effects, according to a new international study.

The analysis of 136 countries found that 42.6% reported climate-related changes in the prevalence, severity or both of skin diseases.

Presented at the European Academy of Dermatology and Venereology (EADV) Congress 2026, the study found that lower-income countries reported a greater burden.

Lower-Income Countries Report Greater Impact

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More than half of low-income countries (55.6%) and lower-middle-income countries (52.5%) reported climate-related changes in skin disease.

This compared with 43.8% of upper-middle-income and 28.3% of high-income countries.

Regional differences were also substantial:

• Western Pacific: 64.7%
• Eastern Mediterranean: 60%
• South-East Asia: 60%
• Europe: 16.1%

In Africa, 42.9% of respondents were unsure about climate change's impact on skin disease, suggesting gaps in surveillance and evidence.

Heat Rashes, Inflammatory Skin Diseases Rising

Among the 58 countries reporting climate-related effects, the most commonly reported changes included:

• Heat rashes: 81%
• Inflammatory skin diseases: 75.9%
• Infectious skin diseases: 62.1%
• Vector-borne diseases: 50%

“The most important finding from our study is that climate change is already associated with negative impacts on skin disease, and these effects disproportionately burden lower-income settings,” said Dr. Esther Freeman, study author and Associate Professor of Dermatology at Harvard Medical School.

How Climate Change Affects Skin

Read More: World Environment Day 2026: How Climate Change Is Increasing the Global Disease Burden | Explained

Rising temperatures, humidity, changing rainfall, air pollution and other environmental exposures can influence both the onset and severity of skin conditions.

Freeman said higher temperatures and humidity can increase sweating and skin irritation, while heat and air pollution may trigger or worsen inflammation.

“Shifts in temperature and rainfall can also affect the habitats of mosquitoes, ticks and other disease vectors, potentially allowing them to survive in places where they were previously uncommon,” she added.

Why Lower-Income Countries Face Greater Risks

The findings point to a wider climate-health disparity. Countries with fewer resources reported more climate-related changes in skin disease, despite generally contributing less to climate change.

These countries may also have fewer resources for disease surveillance, healthcare and climate adaptation.

The researchers called for stronger monitoring, greater awareness among healthcare professionals and locally tailored strategies.

Extreme Weather Can Trigger Skin Problems

The skin is constantly exposed to environmental conditions, making it particularly vulnerable to extreme weather events like flooding, wildfire smoke, etc.

• Flooding: It can increase traumatic injuries and bacterial or fungal infections, while contaminated water can trigger contact dermatitis.
• Wildfire smoke: Smoke and air pollution can worsen skin inflammation, including eczema.
• Heat waves: Prolonged exposure can aggravate inflammatory skin conditions and, in severe cases, contribute to heat exhaustion and heat stroke.
• Hot and humid weather: These conditions may increase some bacterial, fungal and viral infections.

As climate patterns change, the researchers said stronger surveillance and greater awareness of these emerging skin-health risks will be increasingly important.

Freeman stressed the need “to start treating skin health as part of climate-health preparedness.”

Key priorities include:

• Strengthening surveillance
• Improving climate-health education
• Developing locally relevant adaptation strategies
• Accounting for differences in healthcare resources.