The main cause of death globally is still heart disease. Heart attacks may occur suddenly without any warning signs. However, in the film industry, intense chest pain would be portrayed for a heart attack. In actuality, many patients have slight symptoms that go unnoticed until the time of their heart attack days or even weeks prior to that.

Heart attacks do not always announce themselves with dramatic chest pain. Often, they manifest in subtle, easy-to-dismiss ways. Recognizing these overlooked warning signs and taking proactive steps toward cardiovascular health can save lives. If you or someone you know experiences any of these symptoms, seeking immediate medical care is crucial. Prioritizing heart health today can help prevent life-threatening complications in the future.

Warning Sings of A Heart Attack

1. Discomfort Pressure in the Chest

One of the earliest and most common warning signs of an impending heart attack is pressure, tightness, or fullness in the chest. This pain is not typically sharp and sudden, like most people associate with a heart attack, but it can be intermittent, coming in waves, and lasting for several minutes before fading away. According to the American Heart Association, this is one of the red flags when accompanied by exertion. If you have persistent chest pressure, you should call emergency services immediately.

2. Pain Radiating to Other Parts of the Body

The well-known symptom of chest pain can also manifest discomfort related to a heart attack as pain radiating to other parts of the body. It is not unusual for people experiencing this kind of heart attack to report feeling pain in the shoulders, arms, back, neck, and even jaw. The vagus nerve is one that connects the heart to the brain, abdomen, and neck. The pain may be referred to these regions. In case you experience a sudden, unexplained pain in these regions, especially when exercising, seek a doctor's opinion.

3. Dizziness and Lightheadedness

Feeling dizziness upon standing up quickly or missing a meal is common, but unexplained dizziness often with chest pain or shortness of breath is the first sign of heart attack. Sudden hypotension can seriously decrease the blood supply to the brain and cause dizziness. Dizziness that does not go away on its own should not be ignored.

4. Unexplained Fatigue

It often happens that excessive tiredness, particularly in a busy lifestyle, is considered trivial, but ongoing fatigue, mostly in women, is a predictor of heart failure. According to some studies, extreme fatigue often starts a month before a heart attack, primarily in women. This is simply because the heart cannot pump well enough, leaving insufficient oxygen available to muscles and organs. Consult a healthcare professional if you become increasingly tired over time, yet are getting all the rest in the world.

5. Nausea, Indigestion, or Stomach Pain

Digestive problems like nausea, vomiting, or indigestion are often mistaken for acid reflux or food poisoning. However, these symptoms can also indicate reduced blood flow to the digestive tract, a common precursor to heart attacks. If you experience gastrointestinal distress alongside other symptoms like dizziness or chest discomfort, it's important to seek medical advice immediately.

6. Cold Sweats and Excessive Perspiration

Without apparent reason, a heart attack might be signaled by sudden sweating without any exercise or hot weather conditions. The heart's inability to function properly creates the body's "fight or flight" reaction, which means excessive sweating will occur. Be aware of your body and never ignore a cold sweat, particularly if it coincides with other symptoms.

7. Heart palpitations or irregular heartbeat

A racing or irregular heartbeat can be a normal reaction to stress or caffeine consumption. However, regular or unprovoked heart palpitations may indicate that the heart is under duress. If the heart is not getting enough oxygen-rich blood, it can start to beat irregularly. If you experience palpitations along with dizziness, chest pain, or shortness of breath, you should see a doctor right away.

8. Shortness of Breath

If suddenly climbing stairs or performing other everyday activities becomes a problem, then there may be a heart issue. Shortness of breath usually occurs with heart conditions because the circulation is not adequate and less oxygen is provided to the lungs. This symptom can occur either with or without chest pain and is an important indicator of the presence of underlying heart disease. If you find yourself experiencing sudden unexplained breathlessness, then seek a healthcare provider as soon as possible.

When to Seek Medical Attention

Early detection of these symptoms and early intervention can help avoid a life-threatening heart attack. You should visit a doctor if you feel the following symptoms:

• Symptoms induced by exertion and relieved by rest
• The simultaneous onset of several warning signs, including weakness, dizziness, and nausea
• Personal or family history of heart disease, hypertension, diabetes, or smoking

Preventing Heart Attacks: Proactive Steps for Heart Health

Although heart attacks may come out of nowhere, lifestyle plays an important role in reducing a patient's risk; here are some heart-healthy habits to consider:

Take on a Heart-Healthy Diet: Focus on consuming whole foods, lean proteins, healthy fats, and fiber-rich fruits and vegetables. Try to limit processed foods, saturated fats, and added sugars.

Stay Active: Engage in at least 30 minutes of moderate physical activity most days of the week to strengthen your heart and improve blood circulation.

Smoking. Smoking is probably the single largest risk factor for heart disease. If you are a smoker, quitting can easily be the single best thing you can do to improve your heart health.

Deal with Stress: Chronic stress leads to heart disease. Relaxed people through various relaxation techniques including yoga, meditation, and even deep breathing, have lesser stresses.

Regular health checks Monitor blood pressure, cholesterol levels, and blood sugar on a regular basis. The risk factors' early detection can help avoid serious complications.

Dehydration is a serious concern for people fasting during the month-long Ramadan period, and can severely impact kidney and prostate health. Experts suggested that avoiding excess salt and caffeine can help.

While Ramadan fasting is generally safe for people with early-stage chronic kidney disease (CKD), maintaining adequate hydration between iftar and sehri -- the two important meals each day for faithful observing the fasting -- is of significant importance.

Dehydration can lead to acute kidney injury and electrolyte imbalances for individuals with advanced CKD. As prolonged fasting hours -- more than 12 hours a day -- urine becomes concentrated, increasing the risk for kidney stones and Urinary Tract infections (UTIs).

For men with prostate problems, fasting during Ramadan can pose challenges, such as Benign Prostatic Hyperplasia (BPH) or an enlarged prostate, primarily due to dehydration.

“As a practicing urologist and kidney transplant surgeon in India, I often notice a rise in kidney stone pain and urinary infections during Ramzan. When patients fast for long hours -- especially in our warm climate -- urine becomes highly concentrated. That increases the risk of stones and UTIs. Men with prostate enlargement sometimes report worsening urinary flow because they consciously reduce fluid intake,” Dr. Pankaj Panwar, Additional Director, Urology, Fortis Escorts Okhla, New Delhi, told HealthandMe.

The doctor advised people “to hydrate strategically between Iftar and Sehri, avoid excess salt and caffeine”.

How Excess Salt And Caffeine Impact Ramadan Fasting

Consuming high-sodium foods such as processed meats, pickles, salty snacks, and fast food during iftar or sehri can increase thirst and dehydration.

High salt intake forces the body to pull water from cells to dilute the sodium, leading to severe thirst. It can also lead to bloating.

Similarly, caffeine in coffee, tea, chocolate, and energy drinks can be diuretic and cause the body to lose fluids and salts through increased urination. Particularly, drinking coffee or tea at sehri -- the pre-dawn meal -- can lead to faster dehydration during the day.

Caffeine consumption, especially late in the evening, can also interfere with sleep, making it harder to wake up for sehri.

“Ramzan is a sacred month of fasting, but prolonged abstinence from water, especially in hot climates, can increase dehydration risk. Concentrated urine puts stress on the kidneys and may worsen kidney stones or trigger urinary tract infections,” Dr. Mangesh Patil, Urologist at Saifee Hospital, Mumbai, told HealthandMe.

Dehydration during Ramadan fasting can lead to symptoms like headaches, extreme thirst, fatigue, and dizziness. But in case of severe dizziness, fever, confusion, or blurred vision, the experts warned of immediate medical help.

“Do not ignore warning signs like flank pain, fever, or difficulty passing urine. A little planning can prevent an emergency hospital visit,” Panwar said.

Patil said warning signs include severe flank pain, burning urination, fever, vomiting, blood in urine, or reduced urine output. Men with Benign Prostatic Hyperplasia may notice worsening urinary symptoms.

Tips To Prevent Complications

• Drink 2-3 liters of water between iftar and sehri
• Include water-rich fruits
• Avoid excess salt and caffeine
• Individuals with kidney disease, stones, UTIs, or prostate issues should consult their doctor before fasting.

Colon (colorectal) cancer begins when small growths called polyps form on the inner lining of the colon or rectum. Over time, changes in the DNA of these cells can cause the polyps to become cancerous.

As abnormal cells multiply, they replace healthy cells and eventually form a mass known as a tumor. This process develops slowly, often taking up to ten years for a precancerous polyp to turn into cancer and begin showing symptoms.

Colon cancer poses serious health risks because cancerous cells can invade healthy tissues. Over time, they may break away and spread to other parts of the body, making detection more difficult since the symptoms can resemble other conditions.

What Is the First Sign of Colon Cancer You Shouldn’t Ignore?

Colon cancer can be difficult to detect because it often develops without obvious symptoms. However, doctors emphasize that the number one warning sign is rectal bleeding or blood in your stool.

"Colon cancer can be hard to diagnose because it can develop asymptomatically,” said Dr. John Nathanson, a gastroenterologist at New York-Presbyterian Allen Hospital.

Dr. Pratima Dibba adds that this symptom should not be misdiagnosed as hemorrhoids, infection, or constipation, since early signs of colon cancer can look similar.

She urges patients to get checked promptly to rule out serious conditions.

Research from the Cleveland Clinic also shows that blood in stool can originate anywhere in the gastrointestinal tract, including the colon.

Detecting colon cancer early is critical, as survival rates can be as high as 90 percent when caught in its initial stages.

What Are Other Symptoms Of Colon Cancer?

Persistent changes in bowel habits (diarrhea, constipation, or narrowing of stool). Other signs include:

• Abdominal (belly) pain
• Bloated stomach
• Constipation or diarrhea
• Feeling like there’s still poop in your bowel even after you go to the bathroom
• Feeling tired or weak
• Unexplained weight loss

Present Day Scenario In India

Colorectal cancer (CRC) is a major health concern worldwide. In India, it is the fourth most common cancer among both men and women. In 2022, there were 64,863 new cases and 38,367 deaths.

Projections suggest that incidence will continue to rise by 2026, reflecting both lifestyle changes and improved detection.

Compared to developed countries, survival rates in India remain lower, largely due to late-stage diagnosis and limited access to screening programs.

The American Cancer Society notes that colorectal cancer is a cancer that starts in the colon or the rectum. Colorectal cancer impacts around 1.9 million people every year, noted the World Health Organization (WHO) as per its 2022 data.

Some of the risk factors include risk factors involve being over the age 50, family history, certain genetic syndromes (like Lynch syndrome), inflammatory bowel diseases, and lifestyle factors (diet high in red meat, alcohol, smoking, inactivity).

The most effective way to prevent colorectal cancer is through annual colonoscopies, screening and stool tests.

Ever wondered how your body generates antibodies in the face of a virus attack? A new study by French researchers showed that our age, biological sex, and human genetic factors can determine our immunity levels.

The human body, when exposed to a virus, defends itself by producing molecules called antibodies. Their main function is to identify pathogens and kill them.

Scientists from the Institut Pasteur, the CNRS, and the Collège de France noted that these factors not only boost the quantity of antibodies produced in the body but also determine the specific viral regions to target.

The February 2026 study, published in the journal Nature Immunology, can pave the way for the development of personalized treatments, especially for individuals who are most vulnerable to infection.

"This study provides a detailed, integrated view of how age, sex, and human genetics shape the antibody response," said Lluis Quintana-Murci, Head of the Human Evolutionary Genetics laboratory at the Institut Pasteur.

"It shows that these factors even determine which specific regions of a given virus are targeted by antibodies, with important implications for vaccine and therapeutic design," Quintana-Murci added.

How Age And Sex Influence Immunity

The findings revealed that individuals produce antibodies that target different parts of the virus when attacked by the same virus. Age was identified as the dominant factor influencing antibody production. The team noted that more than half of the antibody repertoire varies depending on age.

Further, some antibodies were found to increase with age, while others decreased. This was seen particularly in the case of influenza H1N1 and H3N2 viruses.

In young adults, the antibodies mainly targeted a part of the viral surface protein known as hemagglutinin (HA), which evolves rapidly. In older individuals, it focused on a more stable region of the same protein known as the stalk domain.

Women were also found to produce more antibodies against HA. On the other hand, men tended to target other viral proteins (NP and M1), despite comparable vaccination rates between the two sexes.

How Human Genetics Shape Antibody Production

The team identified mutations in genomic regions known to encode the immunoglobulin repertoire. These variants determine which genes are used to produce antibodies.

Using an African cohort, the study revealed population disparities in terms of the molecular targets of their antibody repertoires.

In the case of Epstein-Barr virus (EBV), antibodies were found to recognize different viral proteins depending on the geographical and epidemiological context.

This difference can be explained by the level of exposure -- Africans are more exposed to a particular strain of EBV in which the protein EBNA-4 is the primary antibody target.

How Was The Study Conducted?

The research is based on data from the Milieu Intérieur cohort, launched 15 years ago to study variations in the immune response in 1,000 healthy individuals.

Using an innovative sequencing technology, the scientists analyzed blood plasma samples to measure antibody responses against more than 90,000 fragments of viral proteins, covering a large number of viruses responsible for infections such as influenza, respiratory infections, gastroenteritis, and herpesvirus infections.