Heart attacks and strokes are among the leading causes of death globally, with millions suffering from cardiovascular diseases (CVD) every year. There are more than seven million people in the UK alone, with about 100,000 patients experiencing heart attacks annually. However, a group of researchers at University College London (UCL) estimate that one 'polypill' taken daily day could eliminate a majority of these cases dramatically lowering death tolls.

The proposed polypill, a combination of a statin and three blood pressure-lowering drugs, has been under study for over two decades. Experts argue that introducing this pill universally for individuals aged 50 and above could be more effective than the current NHS Health Check, which assesses risk factors every five years for those aged between 40 and 74.

Studies have repeatedly proven the effectiveness of the polypill in preventing CVD. A groundbreaking 2019 study in The Lancet found that five years' use of the polypill cut the risk of heart attack and stroke by a third. In addition, previous modelling analyses have estimated that if given universally to people over 55, the polypill might be able to prevent 80% of heart attacks and strokes.

Today, the NHS Health Check follows a risk-based model in which patients are tested for CVD risk factors and treated with drugs accordingly. Yet, as per UCL's study, this system has serious flaws:

Low Uptake: Just 40% of those eligible for the NHS Health Check choose to have it, leaving a considerable number of at-risk patients undiagnosed and untreated.

Ineffective Prediction of Risk: The majority of heart attacks and strokes happen to people at average risk levels, thus making it challenging to identify the need for intervention effectively.

Limited Effectiveness: Even at maximum take-up, the NHS Health Check programme is predicted to have fewer health impacts compared to a polypill initiative applied to the whole population.

Simplicity and Affordability of the Polypill Strategy

One of the big benefits of the polypill is that it is so easy. In contrast to the existing screening-based model, the polypill scheme would not involve complicated medical tests or lengthy risk assessments. Instead, people reaching 50 would just have to fill out a few questions to determine possible side effects before they were prescribed.

Professor Aroon Hingorani of the UCL Institute of Cardiovascular Science, one of the strongest proponents of this scheme, says:

"Finally, the time is now to do much better on prevention. A population approach would prevent a lot more heart attacks and strokes than is done today with a strategy of trying to target a smaller group only."

Aside from the possible health implications, the polypill is also an economic solution. The drugs used are off-patent, thus cheap to produce and distribute. With the vast economic cost of managing CVD-related illnesses, a preventive model could result in substantial cost-saving for the NHS in the future.

The polypill has been proven to be effective by numerous international trials. In 2019, a randomised trial in rural Iran discovered that participants who took the polypill for five years had a 34% reduced risk of having a heart attack or stroke compared to non-participants.

Likewise, modelling research has indicated that even if only 8% of people aged over 50 took up the polypill regimen, it would still be more beneficial to their health than the NHS Health Check programme.

Is This a Case of Over-Medicalisation?

One of the main objections to the polypill strategy is the suggestion that it might result in the unnecessary medicalisation of a significant proportion of the population. But, it is argued, it should be considered as a preventative measure, not as mass medication.

Professor Sir Nicholas Wald of UCL's Institute of Health Informatics explains:

"Instead of being a 'medicalisation' of a significant proportion of the population, a polypill programme is a prevention measure to prevent an individual from becoming a patient."

He compares it with public health measures like water fluoridation or compulsory seatbelts—interventions that have been shown to have a significant impact in reducing public health danger at low individual cost.

With the evidence in favour of the polypill's effectiveness and viability overwhelming, experts are calling on the NHS to act now. It is their belief that substituting the NHS Health Check with a polypill-based prevention program could be the UK government's flagship policy under its pledge to put disease prevention ahead of cure.

As Professor Hingorani points out, "The status quo is not a justifiable option." With CVD still a major cause of death globally, taking a population-wide polypill approach could be a turning point for preventative medicine, potentially saving thousands of lives annually. The question now is whether the NHS will take up this call and establish a policy with the potential to transform the prevention of cardiovascular disease on a national level.

Days after actor Genelia D'Souza revealed she does not feed her children ghee over fears of blocking their arteries and causing heart damage, cardiologists have exclusively revealed to HealthAndMe whether the superfood is healthy for youngsters.

During an episode of Soha Ali Khan’s YouTube podcast 'All About Her', D'Souza said: "Ghee was never a very big part of my diet. I’ve always been more conscious because cholesterol issues run in my family. Whether it was non-vegetarian food or anything else, it was always on my mind, I didn’t want to go overboard.

"We start building habits early. You can't keep feeding children excessive amounts of certain foods and then expect them to suddenly not be overweight and head to the gym later in life. It has to make sense."

And Dr Lakshmi Sukumaran, cardiologist and cardiac anesthesiologist at Metromed International Cardiac Centre agrees!

The specialist told the publication: "Children need appropriate fat for growth, brain development, and hormone synthesis. However, children also do not need excess saturated fat.

"Small amounts of ghee, a teaspoon added to food is not harmful for healthy children with normal weight, active lifestyle and no genetic lipid disorders.

What should be avoided is high daily intake, especially when combined with sedentary lifestyle and calorie excess."

Is Ghee Indeed Bad For Young Children?

Made from cow milk butter, ghee contains about 130 calories and 15 grams of fat on average. It is also known to be rich in Vitamin A, D, K and E as well antioxidants.

However due to its high saturated fat content, some experts claim ghee can raise bad cholesterol levels in some people. Dr Neville Solomon, pediatric cardiac surgeon at Apollo Hospitals, Chennai further advised that it is important for parents to practice caution over the amount their children are consuming of the superfood.

He exclusively told HealthAndMe: "Excessive intake can be harmful and manifest as weight gain, and indirectly in adulthood, as metabolic syndrome, which can manifest as hypertension, diabetes and raised bad cholesterol and low good cholesterol, which can translate into 'hardening of arteries' and coronary artery disease in adulthood."

Additionally, he suggested that children should be kept away from fried foods, be allowed to to consume ghee in moderation and encouraged to be physically active to maintain cardiac health as they grow.

"A sensible policy, if your child is overweight, it is best to avoid or restrict ghee and related potentially harmful foods like fried items, sweets, salty foods like chips and pickles. Ensure your child is physically active, and screen time is restricted. Adequate sleep and avoiding excessive stress are equally important for the long-term 'heart health' of a child," he said.

What About Adults?

Dr Sukumaran explained that while low amounts of ghee in itself is not unhealthy for children and cannot block arteries, it is necessary for adults to also practice moderation as it can pave the way for development of atherosclerosis, a condition in which plaque builds up inside your arteries over years and cause artery blockage.

She explained: "Ghee is simply a concentrated source of saturated fat. Saturated fats are known to raise LDL cholesterol in many individuals. Elevated LDL is a well-established risk factor for cardiovascular disease. But this effect is dose-dependent, meaning quantity and frequency matter. So, intake of ghee in moderation does not worsen heart health. What matters is long term dietary patterns.

"Studies on ghee consumption show mixed results , some show mild increases in LDL or triglycerides at high intake, while others show neutral effects when intake is modest and part of a traditional diet.

"Science supports moderation, not fear mongering a particular type of food, and certainly not oversimplified statements of celebrities about arterial blockage."

Who Should Avoid Ghee?

Experts recommend those suffering from conditions such as heart, digestive and kidney issues as well as obesity to steer clear from the superfood. Cholesterol patients should also avoid ghee as it is rich in fatty acids that may increase blood pressure and increase the risk of heart disease.

Lastly, those suffering from jaundice should also avoid it as it can cause major problems for the liver. Doctors suggest consuming not more than two teaspoons of ghee every day as it may pose certain health risks.

What Did Genelia Say About Her Children's Diets?

The 38-year-old mother-of-two clarified during the podcase episode that she considers ghee to be a problem when consumed in excess. D'Souza, who follows a strict plant-based lifestyle, explained that ghee, a known superfood, stays far away from her diet and instead she prefers to consume sesame seeds (til) for similar benefits.

She also addressed questions about giving up ghee and butter, stating, "I enjoyed a little bit of ghee and butter, but only in tiny portions. So when I eventually gave it up, it wasn’t a big deal," while acknowledging the sensory appeal of ghee, "I know it’s very tasty and it smells amazing."

After Indore water contamination, whose epicentre is Bhagirathpura, that led to the outbreak of diarrhea, with confirmed E coli and Klebsiella bacteria in the water, similar cases form 5 different states have come up. Madhya Pradesh has again made it to the list, now, with Bhopal's water being contaminated.

Greater Noida, Uttar Pradesh : Water Contamination

Residents of Greater Noida's Delta 1 Sector fell ill after consuming contaminated drinking water. This has prompted health concerns and complaints of sewage mixing in the pipe line, said officials and residents.

The residents reported symptoms like vomiting, fever, stomachache and loose motion after consuming tap water in parts of sector on Tuesday and Wednesday. However, the officials of the Greater Noida Industrial Development Authority (GNIDA) denied mixing of sewage with portable water supply, claiming tests conducted so far has found the water to be clean. However, Harendra Bhati, a resident of Beta 1 Sector, society located nearby, claimed that sewage overflow is a common problem in several parts of Greater Noida, as reported by NDTV.

Gandhi Nagar, Gujarat: Water Contamination

In Gujarat's Gandhi Nagar, typhoid outbreak was traced to contaminated drinking water. Residents have been affected by sewage mixing into pipelines, which were meant to deliver clean water. Official from Gandhinagar Civil Hospital, as reported by The Indian Express said that many complaint of high grade fever, abdominal pain, nausea, and vomiting. Most of the patients are in the age group of 1 to 16.

“Various samples were taken and they showed fecal contamination,” reported The Indian Express.

Hyderabad, Telangana: Water Contamination

Four of Hyderabad's 6 water sources were found to be critically polluted, according to a study titled Assessment of Water Quality of Osmansagar, by the scholars of Maulana Azad National Urdu University (MANUU). Hyderabad draws 600 million gallons water per day from six major sources, they include: Osmansagar, Himayatsagar, Singur, Manjeera, Akkampally (Krishna) and Sripada Yellampalli (Godavari).

Very poor levels of pollutant have been found in Osmansagar, Himayatsagar, Krishna and Godavari. As per researchers, untreated sewage from nearby residential areas are reported to flow directly into the lake. the problem is worsened due to the surrounding industries as well as pesticides and fertilizers. The researchers noted: “Fecal contamination clearly points to serious health hazards."

Also Read: Indore Water Contamination Linked to E. coli and Klebsiella Bacteria — What Are They?

Rohtak and Jhajjar, Haryana: Water Contamination

Residents from Haryana's Rohtak and Jhajjar also reported that they have been receiving dirty, foul-smelling water, sometimes even black in color. This situation has forced many families to fetch daily use and drinking water from far away areas or purchase it from private tanker.

Mayank, JE (Civil) with the Public Health and Engineering Department, said in response to an online complaint that efforts are underway to trace the source of the contaminated water supply. The problem is likely to be resolved within seven to ten days, as preliminary findings suggest a damaged household connection, currently being identified through excavation and pipeline inspections.

Bhopal, Madhya Pradesh: Water Contamination

Groundwater samples collected from four locations in Bhopal have tested positive for E. coli bacteria. In response, the Bhopal Municipal Corporation has barred residents from using groundwater for any purpose.

Read: E. Coli Detected In Bhopal Groundwater: Symptoms To Watch And How To Stay Safe

Officials clarified that the contamination is restricted to underground water sources and has not spread to the treated piped water supplied across the city. According to ANI, civic teams have tested 1,810 water samples so far and inspections are still underway in all zones.

Delhi is not just breathing toxic air, but also a superbug through its air, which was found in a latest research conducted by the researchers are Jawaharlal Nehru University, published in Nature - Scientific Reports. Apart from the heavy particulate matter or the PM2.5, which are small enough to penetrate through one's bloodstream and cause blockage, Delhi's air also contains airborne bacteria, including staphylococci. The bacteria levels exceed the safety limit by 16-fold as provided by the World Health Organization (WHO).

According to scientists most of these bacteria are methicillin resistant and unaffected by multiple antibiotic classes. This has raised concerns about the hard to treat and life threatening air that people are breathing in Delhi, also responsible for causing respiratory infections. While Delhi's AQI may have improved in the past few days and come down to 'very poor' from 'severe', high levels of particulate matter still put many people at the risk of aggravated asthma and cardiovascular disease. However, the added finding of the antimicrobial resistant superbug also adds a new layer of threat to residents.

Many have left the city already due to the toxic air. Aflah Ul Haque, a 33-year-old Media and Communications PR consultant had been living in Delhi since 2017. However, in 2024, he considered to move out. He is now living in Aligarh. While he did face difficulties to uproot himself from a metro city like Delhi, as it had become his comfort zone, it was a decision he had to take for a healthy life. Health and Me also previously reported stories of people who shifted or are actively considering shifting out of the city. Will more people consider the same move now that a superbug is found in the air? This is yet to be seen.

Read: Connection Between Migration And Pollution: People Are Leaving City To Be Away From Delhi's Toxic Air

What Did PM Modi Say About Antimicrobial Resistance?

India is already fighting a battle with antimicrobial resistance or AMR, with the breakthrough of Zaynich, a drug to treat AMR, there is hope, however, one still needs to be extra careful. On December 28, 2025, Prime Minister Narendra Modi on the 129th edition of "Mann Ki Baat", spoke about AMR. He pointed out that this is a matter of concern and cited data from the Indian Council of Medical Research (ICMR) showing that antibiotics are becoming less effective against pneumonia and urinary tract infections. He also pointed out that in India, this is a crisis due to "thoughtless and indiscriminate use of antibiotics by people".

How Was The Study That Found Superbug In Delhi's Air Conducted?

In order to understand what people might be breathing in, the researchers collected air samples from a range of everyday locations across Delhi, such as:

• Crowded market areas
• Urban slum neighborhoods
• Residential apartments
• A sewage treatment plant located within the JNU campus

Both indoor and outdoor air samples were taken during summer, monsoon and winter to track how bacterial levels and resistance patterns shifted with the seasons.

Across every setting, airborne bacteria levels were far above the World Health Organization’s recommended safe limit for microbial exposure. In some winter samples, bacterial counts exceeded 16,000 colony-forming units per cubic meter, which is more than 16 times higher than the WHO guideline.

What raised even greater concern was the type of bacteria detected. Many belonged to the Staphylococcus group, which includes strains linked to skin infections, pneumonia, bloodstream infections and illnesses commonly acquired in hospitals.

According to the researchers, a large share of the airborne bacteria were identified as methicillin-resistant staphylococci (MRS), meaning they do not respond to commonly prescribed antibiotics. Among these:

73 per cent were multidrug-resistant, showing resistance to several classes of antibiotics

Many were resistant to macrolides, beta-lactams, trimethoprim, gentamicin and other commonly used drugs

Genetic analysis confirmed the presence of antibiotic resistance genes (ARGs)

Notably, 14 out of 36 multidrug-resistant samples carried the mecA gene, a well-known marker that makes bacteria resistant to methicillin and related antibiotics.

Why Is Winter Smog Linked To Drug-Resistant Bacteria?

The study showed that levels of airborne drug-resistant bacteria were highest in winter, while monsoon rains led to a sharp drop in outdoor contamination.

Researchers point to a few likely reasons:

• Poor air movement in winter traps pollutants and microbes near ground level
• High levels of particulate matter may give bacteria surfaces to cling to and spread
• Cooler temperatures and lower humidity allow bacteria to survive longer in the air

On the other hand, rainfall during the monsoon appears to clear bioaerosols from the air, reducing bacterial concentrations outdoors.