Heart attacks and strokes are among the leading causes of death globally, with millions suffering from cardiovascular diseases (CVD) every year. There are more than seven million people in the UK alone, with about 100,000 patients experiencing heart attacks annually. However, a group of researchers at University College London (UCL) estimate that one 'polypill' taken daily day could eliminate a majority of these cases dramatically lowering death tolls.

The proposed polypill, a combination of a statin and three blood pressure-lowering drugs, has been under study for over two decades. Experts argue that introducing this pill universally for individuals aged 50 and above could be more effective than the current NHS Health Check, which assesses risk factors every five years for those aged between 40 and 74.

Studies have repeatedly proven the effectiveness of the polypill in preventing CVD. A groundbreaking 2019 study in The Lancet found that five years' use of the polypill cut the risk of heart attack and stroke by a third. In addition, previous modelling analyses have estimated that if given universally to people over 55, the polypill might be able to prevent 80% of heart attacks and strokes.

Today, the NHS Health Check follows a risk-based model in which patients are tested for CVD risk factors and treated with drugs accordingly. Yet, as per UCL's study, this system has serious flaws:

Low Uptake: Just 40% of those eligible for the NHS Health Check choose to have it, leaving a considerable number of at-risk patients undiagnosed and untreated.

Ineffective Prediction of Risk: The majority of heart attacks and strokes happen to people at average risk levels, thus making it challenging to identify the need for intervention effectively.

Limited Effectiveness: Even at maximum take-up, the NHS Health Check programme is predicted to have fewer health impacts compared to a polypill initiative applied to the whole population.

Simplicity and Affordability of the Polypill Strategy

One of the big benefits of the polypill is that it is so easy. In contrast to the existing screening-based model, the polypill scheme would not involve complicated medical tests or lengthy risk assessments. Instead, people reaching 50 would just have to fill out a few questions to determine possible side effects before they were prescribed.

Professor Aroon Hingorani of the UCL Institute of Cardiovascular Science, one of the strongest proponents of this scheme, says:

"Finally, the time is now to do much better on prevention. A population approach would prevent a lot more heart attacks and strokes than is done today with a strategy of trying to target a smaller group only."

Aside from the possible health implications, the polypill is also an economic solution. The drugs used are off-patent, thus cheap to produce and distribute. With the vast economic cost of managing CVD-related illnesses, a preventive model could result in substantial cost-saving for the NHS in the future.

The polypill has been proven to be effective by numerous international trials. In 2019, a randomised trial in rural Iran discovered that participants who took the polypill for five years had a 34% reduced risk of having a heart attack or stroke compared to non-participants.

Likewise, modelling research has indicated that even if only 8% of people aged over 50 took up the polypill regimen, it would still be more beneficial to their health than the NHS Health Check programme.

Is This a Case of Over-Medicalisation?

One of the main objections to the polypill strategy is the suggestion that it might result in the unnecessary medicalisation of a significant proportion of the population. But, it is argued, it should be considered as a preventative measure, not as mass medication.

Professor Sir Nicholas Wald of UCL's Institute of Health Informatics explains:

"Instead of being a 'medicalisation' of a significant proportion of the population, a polypill programme is a prevention measure to prevent an individual from becoming a patient."

He compares it with public health measures like water fluoridation or compulsory seatbelts—interventions that have been shown to have a significant impact in reducing public health danger at low individual cost.

With the evidence in favour of the polypill's effectiveness and viability overwhelming, experts are calling on the NHS to act now. It is their belief that substituting the NHS Health Check with a polypill-based prevention program could be the UK government's flagship policy under its pledge to put disease prevention ahead of cure.

As Professor Hingorani points out, "The status quo is not a justifiable option." With CVD still a major cause of death globally, taking a population-wide polypill approach could be a turning point for preventative medicine, potentially saving thousands of lives annually. The question now is whether the NHS will take up this call and establish a policy with the potential to transform the prevention of cardiovascular disease on a national level.

Just ahead of Holi, the Food Safety and Standards Authority of India (FSSAI) seized fake paneer near Noida, along with 1,400 kg of fake khoya in Jhansi, and 400kg of expired ghee. The FSSAI started a series of raids in the Indian state of Uttar Pradesh and Rajasthan ahead of the festivities, when the demands of these food items are increased. Health and Me previously reported on the FSSAI raids in Kanpur where oil, rotten dates, and sweets were found to be adulterated.

Paneer Seized Near Noida At Yamuna Express Way

FSSAI on 27 February posted a video where officials could be seen disposing of a large quantity of adulterated paneer at a landfill site. FSSAI noted that the consignment was intercepted late at night at Jewar Toll Plaza on the Yamuna Expressway. The sample was seized and sent for laboratory testing, while rest of the stock was destroyed immediately.

From time and again news of adulterated paneer have made headline. Fake paneer is an adulterated, non-dairy, or low-quality substitute made using starch, hydrogenated oil (vanaspati), urea, detergent, or ammonium sulphate to mimic real milk cheese. It is found in street foods and local markets, and feels rubbery.

How to test fake paneer? The easy way to test is to use iodine on it, and if it turns blue or black, it means it is fake.

Read: Kanpur Food Adulteration: FSSAI Seizes 14,000L of Oil, 1320Kg Rotten Dates And More Ahead Of Festive Season

1,400 kg Of Adulterated Khoya In Jhansi

In another series of raid by FSSAI in Jhansi, officials confiscated nearly 1,400kg of adulterated khoya. This too happened as a part of a late night operation.

A mobile laboratory unit detected starch adulteration and fungal contamination in the product. The khoya confiscated was worth 3.5 lakh and was destroyed on the spot after inspectors determined that they were unsafe for consumption.

In the images shared by FSSAI, it could be clearly seen that mould-infested khoya had been dumped and discarded.

Expired Food Seized In Rajasthan

FSSAI on March 1 raided in Salumbar district of the Indian state of Rajasthan, where authorities confiscated nearly 400 kg of expired and contaminated food items. This included ghee, cooking oil, tea leaves and spices. Samples from several shops were collected and sent for tests.

Cases Of Contaminated Food In India

Not too long ago, Health and Me reported food contamination from Indore's Bhagirathpura, the same place which was the epicentre of water contamination that took many lives. Health and me also reported the news of Horlicks adulteration in Odisha.

In another news, bacteria were found in Amul milk packages, along with Mother Dairy and Country Delight. Eggoz too landed in a controversy, when a YouTube video went viral claiming that the sample tested positive for Nitrofuran.

MicrobioTx, a Bengaluru-based gut health startup tested samples from urban populations across 9 Indian states and 14 cities and found that people are significantly exposed to pesticides, insecticides, antibiotics, steroidal growth regulators, and forever chemicals.

The independent study found:

• 78% were exposed to pesticide residues, with 36% exposed to three or more pesticides, indicating cumulative exposure that may pose serious health risks.
• 54% showed presence of antibiotics, linked to antimicrobial resistance, harder-to-treat infections, and disruption of the gut microbiome that may contribute to metabolic disorders.
• 39% were exposed to steroids, compounds that may cause endocrine disruption and increased carcinogenic risk.
• 38% tested positive for forever chemicals, persistent toxins that may cause cancer risk, reduced fertility, thyroid disease, hormone suppression, high cholesterol, liver damage, and ulcerative colitis.
• 17% of the samples had 10 or more toxins in their blood across 3 categories, indicating hidden chronic exposure.

In a significant breakthrough for faster diagnosis of tuberculosis -- the world’s most infectious disease --, the World Health Organization (WHO) has recommended tongue swab tests.

The new recommendations come as many people with TB do not produce sputum, but are contributing to transmission. The swab tests may not only expand access to testing but also enable early and timely treatment that can help break chains of TB transmission.

The updated guidance also includes recommendations for the use of near point-of-care molecular tests - the nucleic acid amplification tests (NPOC-NAATs) for drug-resistant TB and pooling of sputa as a diagnostic strategy for the initial detection of TB and drug resistance.

“The WHO has just issued recommendations on new near-point-of-care (NPOC) tests for the diagnosis of #TB; easy-to-collect tongue swab samples to expand access to testing; & a cost-saving sputum pooling strategy to increase testing efficiency for TB & RR-TB,” Tereza Kasaeva, Director - WHO department on HIV, Tuberculosis, Hepatitis, in a post on social media platform X.

“These new recommendations mark a major step toward making #TB testing faster and more accessible,” she said, while calling on countries to roll out the guidelines to close diagnostic gaps.

What Are Tongue Swabs

Tongue swabs are new, readily available, and easy-to-collect specimens for use with NPOC-NAATs and low-complexity automated NAATs (LC-aNAATs) for the initial detection of TB, with and without drug resistance.

The global health body recommends using the low-complexity automated NAATs as initial diagnostic tests in adults and adolescents with signs and symptoms of lung TB.

However, in cases where respiratory samples such as sputum (expectorated or induced), tracheal aspirate, and bronchoalveolar lavage (BAL) cannot be obtained, tongue swabs may be used as initial diagnostic tests for TB.

Tongue swabs may be collected by trained personnel or self-collected with guidance from trained personnel.

Dr Rakesh PS, from the International Union Against Tuberculosis and Lung Disease (The Union), in a LinkedIn post mentioned individuals having no or minimal symptoms, and often cannot present respiratory specimens.

"Tongue swabs offer a practical way to include this otherwise “missed” group in the diagnostic pathway. By enabling testing of individuals who would otherwise be excluded, tongue swab–based testing can enhance the efficiency of active systematic screening," Dr. Rakesh said.

"Tongue swabs are a strategic alternative when obtaining a respiratory specimen is difficult or not possible -- and, when used appropriately, they can strengthen our fight against TB," he added.

What Are NPOC-NAATs

NPOC-NAATs are swab-based molecular tests for TB detection that can produce results from a primary sputum or tongue swab sample in less than one hour. These tests use instruments that can be battery-operated and do not require specialized infrastructure for use or storage.

The tests can be done in basic peripheral laboratories, such as those that perform smear microscopy, and health clinics, mobile units, or community sites that do not have laboratories.

They can be performed by health care workers with basic technical skills because they do not require laboratory methods like precision pipetting.

What Is Sputa Pooling

In sputum pooling, samples from several individuals are mixed and tested together. It is a proven strategy to improve testing efficiency and reduce costs in resource-constrained environments.

Global TB burden

While being preventable and curable, TB remains a top infectious killer, with an estimated 10.7 to 10.8 million new cases and 1.23–1.25 million deaths in 2024, as per WHO.

The infectious disease disproportionately affects low- and middle-income countries.

While TB incidence rates have shown a slight, uneven decline since 2015, the overall burden remains high, with 30 countries accounting for 87 percent of global cases, led by India, Indonesia, China, the Philippines, and Pakistan.

An increasing number of the National Health Service or the NHS UK doctors are now choosing to practise privately. This has happened at the backdrop of mounting pressures and burnout that reshaped the landscape of general practice in England. According to a recent BBC report on Care Quality Commission (CQC), data found a sharp rise in doctors registering to work outside the NHS.

In the five years to the end of 2025, the CQC received 1,238 new registrations for "independent consulting doctors" in England. This is a 212 per cent increase as compared to 396 doctors registering to work independently over the five years. Between 2024 and 2025, registrations rose by 58 per cent.

Independent consulting doctors provide care privately, either in person or online, across a range of specialties including general practice, skin conditions, women’s health and aesthetics.

"You Don't Have Time To Go To The Toilet"

Dr Yvonne Girgis-Hanna is among those dividing her time between NHS and private practice. Speaking to the BBC, she said full-time NHS work had become unsustainable.

“I could not work as a full-time NHS GP,” she said. “The days I do in the NHS, the next day I'm totally wiped out… You might have 30 face-to-face contacts, then extra telephone calls and paperwork. You just don't have time to even go to the toilet.”

She now sees private patients in Essex, charging from £129 for a 20-minute appointment, with options of up to an hour. Longer consultations, she told the BBC, allow for continuity of care reminiscent of the “cradle to grave” model that once defined family medicine.

Demand, she argues, is the central strain on NHS general practice. With practices receiving roughly £120 per patient annually, frequent attenders can stretch resources thin. “If you imagine £120 for somebody that might be presenting 20 times, it is very little,” she said.

Patients Pay For Time And Familiarity

A 2024 LaingBuisson report noted that 13 per cent of GP consultations were private, which is up by 3 per cent two decades ago. This is because, some patients want faster access and longer appointments. Vanessa Ravazzotti, 51, told BBC that NHS wait worsened her symptoms and heightened anxiety. This is when seeing a private GP felt "mentally better". "She knows me; I know her."

Ian Miller, 85, who has arthritis, told the BBC he found short NHS appointments difficult and disliked seeing different clinicians. Private care offered familiarity and focus: “You immediately get down to the problem.”

Greater Autonomy, But Less Affordability

Dr Karen Benson, who works privately from a pharmacy in Hertfordshire, said the environment is calmer. “I haven't got constant interruptions… it's a much more relaxed atmosphere." She said she is better able to offer longer appointments and address the root cause of the illness. However, some patients switch back to NHS for specialist referrals that they cannot afford privately.

Dr Oliver Denton of the British Medical Association (BMA) told the BBC that while it is difficult to pinpoint a single cause, “with growing pressures within the NHS it is no wonder more may be considering looking to work outside the health service.”