Heart attacks and strokes are among the leading causes of death globally, with millions suffering from cardiovascular diseases (CVD) every year. There are more than seven million people in the UK alone, with about 100,000 patients experiencing heart attacks annually. However, a group of researchers at University College London (UCL) estimate that one 'polypill' taken daily day could eliminate a majority of these cases dramatically lowering death tolls.

The proposed polypill, a combination of a statin and three blood pressure-lowering drugs, has been under study for over two decades. Experts argue that introducing this pill universally for individuals aged 50 and above could be more effective than the current NHS Health Check, which assesses risk factors every five years for those aged between 40 and 74.

Studies have repeatedly proven the effectiveness of the polypill in preventing CVD. A groundbreaking 2019 study in The Lancet found that five years' use of the polypill cut the risk of heart attack and stroke by a third. In addition, previous modelling analyses have estimated that if given universally to people over 55, the polypill might be able to prevent 80% of heart attacks and strokes.

Today, the NHS Health Check follows a risk-based model in which patients are tested for CVD risk factors and treated with drugs accordingly. Yet, as per UCL's study, this system has serious flaws:

Low Uptake: Just 40% of those eligible for the NHS Health Check choose to have it, leaving a considerable number of at-risk patients undiagnosed and untreated.

Ineffective Prediction of Risk: The majority of heart attacks and strokes happen to people at average risk levels, thus making it challenging to identify the need for intervention effectively.

Limited Effectiveness: Even at maximum take-up, the NHS Health Check programme is predicted to have fewer health impacts compared to a polypill initiative applied to the whole population.

Simplicity and Affordability of the Polypill Strategy

One of the big benefits of the polypill is that it is so easy. In contrast to the existing screening-based model, the polypill scheme would not involve complicated medical tests or lengthy risk assessments. Instead, people reaching 50 would just have to fill out a few questions to determine possible side effects before they were prescribed.

Professor Aroon Hingorani of the UCL Institute of Cardiovascular Science, one of the strongest proponents of this scheme, says:

"Finally, the time is now to do much better on prevention. A population approach would prevent a lot more heart attacks and strokes than is done today with a strategy of trying to target a smaller group only."

Aside from the possible health implications, the polypill is also an economic solution. The drugs used are off-patent, thus cheap to produce and distribute. With the vast economic cost of managing CVD-related illnesses, a preventive model could result in substantial cost-saving for the NHS in the future.

The polypill has been proven to be effective by numerous international trials. In 2019, a randomised trial in rural Iran discovered that participants who took the polypill for five years had a 34% reduced risk of having a heart attack or stroke compared to non-participants.

Likewise, modelling research has indicated that even if only 8% of people aged over 50 took up the polypill regimen, it would still be more beneficial to their health than the NHS Health Check programme.

Is This a Case of Over-Medicalisation?

One of the main objections to the polypill strategy is the suggestion that it might result in the unnecessary medicalisation of a significant proportion of the population. But, it is argued, it should be considered as a preventative measure, not as mass medication.

Professor Sir Nicholas Wald of UCL's Institute of Health Informatics explains:

"Instead of being a 'medicalisation' of a significant proportion of the population, a polypill programme is a prevention measure to prevent an individual from becoming a patient."

He compares it with public health measures like water fluoridation or compulsory seatbelts—interventions that have been shown to have a significant impact in reducing public health danger at low individual cost.

With the evidence in favour of the polypill's effectiveness and viability overwhelming, experts are calling on the NHS to act now. It is their belief that substituting the NHS Health Check with a polypill-based prevention program could be the UK government's flagship policy under its pledge to put disease prevention ahead of cure.

As Professor Hingorani points out, "The status quo is not a justifiable option." With CVD still a major cause of death globally, taking a population-wide polypill approach could be a turning point for preventative medicine, potentially saving thousands of lives annually. The question now is whether the NHS will take up this call and establish a policy with the potential to transform the prevention of cardiovascular disease on a national level.

Amid a record-high measles outbreak in the US, Pennsylvania has reported the first measles deaths of 2026, involving two unvaccinated individuals.

According to a statement by the Pennsylvania Department of Health (DOH), the confirmed deaths “mark the first deaths related to measles within the Commonwealth in 35 years.”

Both people were unvaccinated residents of Lancaster County, according to the DOH, which did not release additional details, citing privacy concerns.

“Because measles was largely eliminated in the Commonwealth for more than three decades, people are not familiar with this disease and don't fully understand the potential severity of the illness,” said Pennsylvania Secretary of Health Debra Bogen.

Pennsylvania has been one of the hardest-hit states this year. So far, 393 cases of the contagious virus has been reported across 28 counties. Lancaster County, in the southeastern part of the state, has recorded 185 cases.

MMR Vaccine Offers Strong Protection

The best protection against measles is getting fully vaccinated. The MMR vaccine, administered over two doses, boosts a person’s immune system and provides 97% lifetime protection.

However, vaccination rates and policies under the President Donald Trump, along with long-term vaccine skeptic Health Secretary Robert F. Kennedy Jr., have led to a severe decline in immunization rates.

As per the latest figures from the US CDC, the country has recorded 2,777 confirmed measles cases this year, a disease that had been largely eradicated in the country.

Notably, the increase in cases also means that the US is set to lose its status for having eradicated measles.

Trump, Kennedy Push for Vaccine Changes

Moreover, Kennedy and President Donald Trump, earlier this month, issued an executive order calling for a reduction in recommended childhood vaccines and also promoted a long-debunked link between vaccines and autism, contrary to established scientific evidence.

“We all thought the Texas outbreak and the deaths there last year would be a wake-up call. Then we had the outbreaks in South Carolina and Utah,” said Dr. Angela Dunn, former Utah state epidemiologist and previously a CDC division director in infectious disease response, Reuters reported.

In 2025, three people died in an outbreak that began in West Texas and spread to New Mexico.

How Does Measles Spread?

Measles is a highly contagious virus that can cause serious short- and long-term health problems, including pneumonia and brain swelling. Nearly 20% of people who contract measles are hospitalized. Death related to measles, though rare, occurs in one to three patients per 1,000 cases.

Measles spreads when an infected person breathes, coughs, or sneezes. The virus remains infectious in the air and on surfaces for up to two hours after the person with the infection leaves the area.

Measles Symptoms

Early symptoms of measles include fever, cough, runny nose, and red, watery eyes (conjunctivitis). The measles rash follows a few days later, starting on the head and spreading downward.

Because early symptoms can look similar to other respiratory viral infections, it is important to contact a healthcare provider early if someone has these symptoms or may have been exposed to measles.

Symptoms can start 7 to 21 days after exposure. Without proper protection or supportive care, measles can be deadly.

Even as Delhi’s H1N1 cases crossed 2,300, Director General of the Indian Council of Medical Research (ICMR) Dr. Rajiv Bahl today said there was “absolutely no cause for panic” and that seasonal influenza remains largely self-limiting.

Speaking to the media, Dr. Bahl said no new or unusual virus strain has been detected and that the rise in cases reflects expected seasonal changes.

The virus currently circulating in the country is the familiar H1N1 pdm09 strain that emerged during the 2009 pandemic and has since become a seasonal influenza virus.

The circulating Influenza A (H1N1) viruses have been identified as A/Missouri/11/2025 (H1N1) pdm09-like viruses. Hemagglutinin (HA) gene analysis places the isolates in clade 6B.1A.5a2a, subclade D.3.1.1.

Dr. Bahl said this lineage has been in continuous circulation in India since 2025. The genetic changes observed are consistent with the normal antigenic drift seen in seasonal influenza viruses.

Such minor genetic changes occur routinely as influenza viruses circulate and, by themselves, do not indicate the emergence of a new or dangerous strain.

No Urgent Need for Flu Vaccine

Dr. Bahl, who is also Secretary of the Department of Health Research (DHR), said there is no urgent need for everyone to take the flu vaccine.

He added that individuals above 65 and those who are immunocompromised may discuss vaccination with their doctors. He said that vaccination is currently only a recommendation from the WHO and is not part of the National Immunization Program.

Who Is at Higher Risk?

Seasonal influenza, including Influenza A (H1N1), is predominantly a mild and self-limiting respiratory illness in otherwise healthy individuals.

Common symptoms include:

• Fever
• Cough
• Sore throat
• Headache
• Body ache
• Fatigue and weakness

In most people, symptoms improve with supportive care, adequate rest and hydration. The presence of H1N1 does not, by itself, mean that a person will develop severe disease or require hospitalization.

However, certain groups have a higher risk of developing complications. These include:

• Elderly persons
• Young children
• Individuals with underlying medical conditions or co-morbidities
• People with compromised immunity

Dr. Bahl advised these individuals to exercise greater caution and seek timely medical advice if they develop influenza-like symptoms.

How to Prevent the Spread of Flu

Dr. Bahl advised the public to follow routine respiratory hygiene and infection-prevention measures.

Do's:

• Cover the mouth and nose while coughing or sneezing.
• Wash hands frequently with soap and water or use an appropriate hand sanitiser.
• Stay at home when unwell and avoid close contact with others.
• Maintain adequate hydration and get sufficient rest.
• Consume a healthy and balanced diet.
• Seek medical advice if symptoms are severe, persistent or worsening.
• Follow medical advice regarding testing or treatment.

Don’t:

• Do not panic because of the detection of H1N1.
• Do not take antivirals or antibiotics without medical advice.
• Avoid close contact with others while symptomatic.
• Avoid touching the eyes, nose and mouth with unwashed hands.

Stay Informed, Not Alarmed

The Ministry of Health said the public should remain “informed and vigilant, but not alarmed.”

Seasonal influenza is a familiar and routinely monitored respiratory infection. Following simple preventive measures, seeking timely medical consultation when required and avoiding unnecessary medication can help protect individuals and communities.

A massive analysis involving more than 100 million people has found strong links between recreational drug use and stroke, including among younger adults.

Stroke remains one of the world's biggest health problems and ranks as the third leading cause of death and disability combined.

The researchers found that cannabis use disorders were associated with stroke overall and were particularly linked to large artery stroke.

The study "provides compelling evidence that drugs like cocaine, amphetamines, and cannabis are causal risk factors for stroke. These findings give us stronger evidence to guide future research and public health strategies," said Dr. Megan Ritson from the Stroke Research Group at the University of Cambridge.

What Did the Study Find?

The team conducted a meta-analysis covering studies with more than 100 million participants. Their results, published in the International Journal of Stroke, showed substantial differences in stroke risk associated with several drugs.

Cocaine and amphetamine use were each linked to roughly twice the risk of stroke.

• Cocaine increased stroke risk by 96%.
• Amphetamine use was associated with a 122% increase.
• Cannabis use was associated with an increase of about 37%.
• Opioid use showed no statistically significant association with stroke risk.

Stroke Risk Was Especially High in Younger Users

The researchers separately examined people under age 55. Within this younger group, amphetamine use was associated with nearly three times the risk of stroke, an increase of 174%.

Cocaine use was associated with a 97% increase in stroke risk, while cannabis was linked to a smaller 14% increase.

Cocaine Linked to Brain Hemorrhage and Cardioembolic Stroke

Further genetic analysis revealed that cocaine use disorders were especially associated with brain hemorrhage and cardioembolic stroke.

In cardioembolic stroke, a blood clot forms in the heart and travels to the brain, blocking blood flow and causing damage to brain tissue.

According to the researchers, these genetic findings support the possibility of a causal relationship rather than an association alone.

Problematic alcohol use was also associated with an increased risk of cardioembolic stroke and large artery stroke. Alcohol addiction, meanwhile, was linked to a greater overall risk of stroke.

How Could Recreational Drugs Increase Stroke Risk?

The researchers noted several biological mechanisms that could help explain why these substances are associated with stroke. These include:

• Sudden increases in blood pressure
• Spasms and narrowing of blood vessels
• Abnormal heart rhythms
• Greater blood clotting, especially with cannabis
• Inflammation or vasculitis, particularly with amphetamines

All of these processes are already known to contribute to stroke. They can play a role in ischemic strokes, which occur when blood clots interrupt blood flow, as well as hemorrhagic strokes.

"Our analysis suggests that it is these drugs themselves that increase the risk of stroke, not just other lifestyle factors among users. Taken together, our findings emphasize the importance of public health measures to reduce substance abuse as a way of helping also reduce stroke risk," said Dr. Eric Harshfield, Alzheimer's Society Research Fellow at the Department of Clinical Neurosciences.