Heart attacks and strokes are among the leading causes of death globally, with millions suffering from cardiovascular diseases (CVD) every year. There are more than seven million people in the UK alone, with about 100,000 patients experiencing heart attacks annually. However, a group of researchers at University College London (UCL) estimate that one 'polypill' taken daily day could eliminate a majority of these cases dramatically lowering death tolls.

The proposed polypill, a combination of a statin and three blood pressure-lowering drugs, has been under study for over two decades. Experts argue that introducing this pill universally for individuals aged 50 and above could be more effective than the current NHS Health Check, which assesses risk factors every five years for those aged between 40 and 74.

Studies have repeatedly proven the effectiveness of the polypill in preventing CVD. A groundbreaking 2019 study in The Lancet found that five years' use of the polypill cut the risk of heart attack and stroke by a third. In addition, previous modelling analyses have estimated that if given universally to people over 55, the polypill might be able to prevent 80% of heart attacks and strokes.

Today, the NHS Health Check follows a risk-based model in which patients are tested for CVD risk factors and treated with drugs accordingly. Yet, as per UCL's study, this system has serious flaws:

Low Uptake: Just 40% of those eligible for the NHS Health Check choose to have it, leaving a considerable number of at-risk patients undiagnosed and untreated.

Ineffective Prediction of Risk: The majority of heart attacks and strokes happen to people at average risk levels, thus making it challenging to identify the need for intervention effectively.

Limited Effectiveness: Even at maximum take-up, the NHS Health Check programme is predicted to have fewer health impacts compared to a polypill initiative applied to the whole population.

Simplicity and Affordability of the Polypill Strategy

One of the big benefits of the polypill is that it is so easy. In contrast to the existing screening-based model, the polypill scheme would not involve complicated medical tests or lengthy risk assessments. Instead, people reaching 50 would just have to fill out a few questions to determine possible side effects before they were prescribed.

Professor Aroon Hingorani of the UCL Institute of Cardiovascular Science, one of the strongest proponents of this scheme, says:

"Finally, the time is now to do much better on prevention. A population approach would prevent a lot more heart attacks and strokes than is done today with a strategy of trying to target a smaller group only."

Aside from the possible health implications, the polypill is also an economic solution. The drugs used are off-patent, thus cheap to produce and distribute. With the vast economic cost of managing CVD-related illnesses, a preventive model could result in substantial cost-saving for the NHS in the future.

The polypill has been proven to be effective by numerous international trials. In 2019, a randomised trial in rural Iran discovered that participants who took the polypill for five years had a 34% reduced risk of having a heart attack or stroke compared to non-participants.

Likewise, modelling research has indicated that even if only 8% of people aged over 50 took up the polypill regimen, it would still be more beneficial to their health than the NHS Health Check programme.

Is This a Case of Over-Medicalisation?

One of the main objections to the polypill strategy is the suggestion that it might result in the unnecessary medicalisation of a significant proportion of the population. But, it is argued, it should be considered as a preventative measure, not as mass medication.

Professor Sir Nicholas Wald of UCL's Institute of Health Informatics explains:

"Instead of being a 'medicalisation' of a significant proportion of the population, a polypill programme is a prevention measure to prevent an individual from becoming a patient."

He compares it with public health measures like water fluoridation or compulsory seatbelts—interventions that have been shown to have a significant impact in reducing public health danger at low individual cost.

With the evidence in favour of the polypill's effectiveness and viability overwhelming, experts are calling on the NHS to act now. It is their belief that substituting the NHS Health Check with a polypill-based prevention program could be the UK government's flagship policy under its pledge to put disease prevention ahead of cure.

As Professor Hingorani points out, "The status quo is not a justifiable option." With CVD still a major cause of death globally, taking a population-wide polypill approach could be a turning point for preventative medicine, potentially saving thousands of lives annually. The question now is whether the NHS will take up this call and establish a policy with the potential to transform the prevention of cardiovascular disease on a national level.

In another MAHA (Make America Healthy Again) meetings, Vice President JD Vance said that he thinks Ibuprofen, a common pain medication, is 'useless'. While speaking at the MAHA summit in Washington DC on November 12, along side the Health and Human Services Secretary Robert F Kennedy Jr, Vance talked about "the one way" he is "more instinctively MAHA".

He was here making a reference to Trump's administration's Make America Healthy Again. This is an initiative led by Kennedy.

This is when Vance said, "If I have like, you know, a back sprain, or I slept weird and I woke up with back pain, I don't want to take Ibuprofen." He said that he does not like taking medications. "I don't like taking anything unless I absolutely have to. And I think that is another MAHA style attitude. It is not anti-medication, it is anti-useless-medication," he said.

His remarks has made with many experts criticizing it. This is not the first time the MAHA flag bearers have faced criticism for their 'MAHA attitudes' and opinions. Earlier the connection between Tylenol, another popular pain medication and autism was also faced with criticism, with expert commenting on why the link is not correct.

In fact, Kennedy, who is leading the MAHA initiative has had a long history of being anti-vaccination and medication, which also includes refusing to promote the measles vaccines amid a measles surge. He also announced that the Centers for Disease Control and Prevention (CDC) would no longer recommend children and pregnant women get COVID vaccines, and the reason he cited was "common sense".

What Does Ibuprofen Do In Your Body?

Many widely used painkillers contain ibuprofen, a medication known for easing pain, reducing inflammation, and lowering fever. It works by blocking certain natural chemicals in the body that trigger swelling and discomfort.

When someone is injured or unwell, the body produces chemicals that heighten nerve sensitivity, making pain feel more intense. Painkillers help slow this process by reducing the production of these chemicals, preventing nerves from sending strong pain signals to the brain, ultimately helping the person feel relief.

Ibuprofen’s main role is to reduce inflammation and soothe pain. By limiting the chemicals that cause discomfort, it also decreases redness and heat in the affected area. This is why it is commonly recommended for muscle spasms and sprains, as noted in a 2015 study in the National Library of Medicine.

The medication also acts on the hypothalamus, the brain’s temperature-regulation center, helping to bring down fever. The same 2015 study suggests that some painkillers may suppress certain immune responses, which can worsen inflammation but make the brain perceive less pain, creating an overall calming effect.

Former world heavyweight champion Joseph Parker faces a potential ban from boxing after testing positive for cocaine, casting a shadow over his October 26 fight with Briton Fabio Wardley. As reported by BBC Sport, the 33-year-old New Zealander returned a positive result for a recreational drug, not a performance-enhancing substance. The sample was collected a day earlier by the Voluntary Anti-Doping Association (VADA).

His promoter, Queensberry Promotions, acknowledged the “adverse finding” but said no further comment would be made while the matter is being investigated. Parker’s UK manager Spencer Brown told Reuters they were “in total shock” and intend to get to the bottom of the development.

Parker could face a ban ranging from three months to two years, depending on circumstances. Although UK Anti-Doping (UKAD) and the British Boxing Board of Control will determine sanctions, UKAD did not administer the test and must conduct its own inquiry before issuing any decision.

The case comes amid broader debates on how recreational drug use should be penalized in elite sports. Sanctions have varied widely in recent years, from a four-year ban for boxer Liam Cameron in 2019 to a three-month ban for rugby league player Adam Rusling in 2024.

Parker, who held the heavyweight world title from 2016–2018, had hoped to work his way toward a fight with undisputed champion Oleksandr Usyk before his surprise loss to Wardley.

Why the Distinction Matters

Parker’s positive test for cocaine has reignited discussion around an important but often misunderstood issue: the difference between recreational drugs and performance-enhancing drugs (PEDs). While both categories are prohibited in competitive sport, their purpose, impact, and penalties differ significantly.

Recreational Drug Use in Sports

Recreational drug use reflects broader social trends. Studies in Western countries show that up to 38% of people have used an illicit drug at least once, with even higher rates among young adults. This behavior inevitably spills into sport, where athletes, like anyone else, may be exposed socially or recreationally.

The World Anti-Doping Agency (WADA) classifies prohibited substances into categories such as stimulants, narcotics, cannabinoids, beta-blockers, and more. Among athletes, the most commonly misused recreational substances include alcohol, cigarettes, and cannabis, particularly among adolescents and collegiate players.

Why Athletes Use Them

• Recreational use in sports can be driven by:
• Social environments
• Stress or pressure to perform
• Age segregation and peer dynamics
• Motivation to relax or cope

In some sports, especially high-contact ones, alcohol use has been shown to be more prevalent.

Testing and Consequences

Although these drugs do not enhance performance, they raise concerns about athlete safety, decision-making, and conduct. Penalties vary widely, as seen in recent cases: some athletes have received multi-year bans, while others served suspensions as short as three months.

Performance-Enhancing Drugs (PEDs)

PEDs are substances deliberately used to boost strength, stamina, speed, or recovery beyond natural limits. Their misuse is far more dangerous and directly threatens fair play.

Common PED categories include:

• Anabolic steroids
• Growth hormone and peptide hormones
• Erythropoietin (EPO)
• Stimulants
• Blood doping agents

These substances are often abused to gain a competitive edge, and their health consequences can be severe.

Risks and Health Damage

PEDs can cause:

• Hypertension, arrhythmias, stroke, heart attacks
• Liver toxicity
• Infertility, hormonal damage, genital changes
• Psychiatric effects such as aggression, depression, mania
• Addiction and withdrawal symptoms
• In extreme cases, death

Steroids are regulated as Schedule III substances, and many PEDs banned in sport are also restricted in general medicine. To ensure athletes can receive legitimate medical treatment, WADA allows Therapeutic Use Exemptions (TUEs) under strict criteria.

Actor Jarryd Nurden, a known name in theatre has finally made his return to the West End stage six months after his surgery that removed half of his lung due to a rare cancer.

Jarryd first thought he had nothing more than a stubborn winter bug. In late 2022, he came down with what felt like a “very bad flu,” pushing through fatigue and discomfort while performing in a Christmas pantomime. He assumed it was simply illness made worse by long rehearsals and a busy stage schedule. But the symptoms persisted, and further medical checks revealed something far more serious than a seasonal infection.

A Flu That Turned Out To Be A Lung Cancer

What Jarryd thought was flu turned out to be a rare form of lung cancer. The doctors re-examined the old medical scans, which had shown minor scarring, which was thought to be form a childhood drowning accident. This is when the doctors discovered a tumor had doubled in size, and it grew from two to four centimeters.

In January 2023, the same day he received news that he had secured a role in We Will Rock You, Jarryd attended an appointment at Guy’s Hospital, where doctors told him about the tumor. “When I had that phone call, that’s when my world crashed,” he told The Independent. “I was like: ‘I’m properly screwed.’”

The Diagnosis Of The Rare Lung Cancer

After months of tests and a keyhole surgery in August 2023 to examine the tumor, doctors confirmed it was primary malignant neuroendocrine neoplasm of the lung (atypical carcinoid), a rare form of lung cancer.

“That phone call I’ve always described as being underwater,” he said to The Independent. “Everything just slows down, and you’re like: ‘Oh, I have cancer’… I don’t drink, I don’t smoke… How’s this happening?”

Though the tumor was removed, some cancerous cells remained. Jarryd was given a choice: chemotherapy and radiotherapy, or a major operation to remove part of his lung. He chose surgery.

In October 2023, he underwent a completion lobectomy, removing the entire lower lobe of his left lung. The recovery was brutal. “Recovery was really hard… I think it was touch and go at one point,” he shared with The Independent. Complications meant four months in hospital, a second open surgery due to infections, and enduring the most intense pain he had ever felt.

Despite the hardship, the Actors’ Trust helped support him financially while he was unable to work. He underwent additional treatment in July 2024 to insert stents into a chest fistula and continued healing.

Way Back To The Stage

Against all odds, just three months after his last surgery, Jarryd accepted an offer to join the international tour of Chicago, covering the role of Mary Sunshine. He rehearsed for one day in London, flew to China, had a two-hour rehearsal, and stepped onstage.

“It was do or die… The challenge was intense,” he told The Independent. Taking his bow afterward was overwhelming. “It was immense gratitude… for being back on stage… being with such a supportive company.”

He added, “I think when you go through something very life-changing, you stop sweating the small stuff… You do have that second chance at life, essentially.”