Heart attacks and strokes are among the leading causes of death globally, with millions suffering from cardiovascular diseases (CVD) every year. There are more than seven million people in the UK alone, with about 100,000 patients experiencing heart attacks annually. However, a group of researchers at University College London (UCL) estimate that one 'polypill' taken daily day could eliminate a majority of these cases dramatically lowering death tolls.

The proposed polypill, a combination of a statin and three blood pressure-lowering drugs, has been under study for over two decades. Experts argue that introducing this pill universally for individuals aged 50 and above could be more effective than the current NHS Health Check, which assesses risk factors every five years for those aged between 40 and 74.

Studies have repeatedly proven the effectiveness of the polypill in preventing CVD. A groundbreaking 2019 study in The Lancet found that five years' use of the polypill cut the risk of heart attack and stroke by a third. In addition, previous modelling analyses have estimated that if given universally to people over 55, the polypill might be able to prevent 80% of heart attacks and strokes.

Today, the NHS Health Check follows a risk-based model in which patients are tested for CVD risk factors and treated with drugs accordingly. Yet, as per UCL's study, this system has serious flaws:

Low Uptake: Just 40% of those eligible for the NHS Health Check choose to have it, leaving a considerable number of at-risk patients undiagnosed and untreated.

Ineffective Prediction of Risk: The majority of heart attacks and strokes happen to people at average risk levels, thus making it challenging to identify the need for intervention effectively.

Limited Effectiveness: Even at maximum take-up, the NHS Health Check programme is predicted to have fewer health impacts compared to a polypill initiative applied to the whole population.

Simplicity and Affordability of the Polypill Strategy

One of the big benefits of the polypill is that it is so easy. In contrast to the existing screening-based model, the polypill scheme would not involve complicated medical tests or lengthy risk assessments. Instead, people reaching 50 would just have to fill out a few questions to determine possible side effects before they were prescribed.

Professor Aroon Hingorani of the UCL Institute of Cardiovascular Science, one of the strongest proponents of this scheme, says:

"Finally, the time is now to do much better on prevention. A population approach would prevent a lot more heart attacks and strokes than is done today with a strategy of trying to target a smaller group only."

Aside from the possible health implications, the polypill is also an economic solution. The drugs used are off-patent, thus cheap to produce and distribute. With the vast economic cost of managing CVD-related illnesses, a preventive model could result in substantial cost-saving for the NHS in the future.

The polypill has been proven to be effective by numerous international trials. In 2019, a randomised trial in rural Iran discovered that participants who took the polypill for five years had a 34% reduced risk of having a heart attack or stroke compared to non-participants.

Likewise, modelling research has indicated that even if only 8% of people aged over 50 took up the polypill regimen, it would still be more beneficial to their health than the NHS Health Check programme.

Is This a Case of Over-Medicalisation?

One of the main objections to the polypill strategy is the suggestion that it might result in the unnecessary medicalisation of a significant proportion of the population. But, it is argued, it should be considered as a preventative measure, not as mass medication.

Professor Sir Nicholas Wald of UCL's Institute of Health Informatics explains:

"Instead of being a 'medicalisation' of a significant proportion of the population, a polypill programme is a prevention measure to prevent an individual from becoming a patient."

He compares it with public health measures like water fluoridation or compulsory seatbelts—interventions that have been shown to have a significant impact in reducing public health danger at low individual cost.

With the evidence in favour of the polypill's effectiveness and viability overwhelming, experts are calling on the NHS to act now. It is their belief that substituting the NHS Health Check with a polypill-based prevention program could be the UK government's flagship policy under its pledge to put disease prevention ahead of cure.

As Professor Hingorani points out, "The status quo is not a justifiable option." With CVD still a major cause of death globally, taking a population-wide polypill approach could be a turning point for preventative medicine, potentially saving thousands of lives annually. The question now is whether the NHS will take up this call and establish a policy with the potential to transform the prevention of cardiovascular disease on a national level.

Nearly nine out of every 10 Indian adults have at least one abnormal blood lipid level, according to a recent nationwide study by ICMR-INDIAB.

The findings highlighted a massive looming public health crisis that could increase the risk of heart attacks, strokes and other cardiovascular diseases across the country in the near future.

India’s Silent Cholesterol Crisis

The findings, which were reported between July 17 and July 19, 2026, reveal that dyslipidemia, an unhealthy imbalance of cholesterol and triglycerides in the blood, affects an alarming number of Indian adults.

Despite being preventable and treatable, the condition often remains undiagnosed because it presents with little to no symptoms until serious complications surface.

The study was conducted by the Indian Council of Medical Research’s India Diabetes (ICMR-INDIAB) in what is one of the country’s largest community-based metabolic health surveys, involving over 113,000 adults from different states and Union Territories.

Also read: As Sonam Wangchuk's Indefinite Fast Continues, Doctors Explain When Hunger Strike Becomes Medically Dangerous

Women And Urban Residents At Greater Risk

According to the study, women, those living in urban areas, and residents of Central India carried a disproportionately higher burden of abnormal lipid levels.

Researchers also found that dyslipidemia was significantly more common among people with prediabetes or diabetes, obesity, and hypertension.

These metabolic conditions substantially increasing the risk of various cardiovascular diseases and complications.

What Is Dyslipidemia?

Dyslipidemia refers to unhealthy levels of fats circulating in the bloodstream. These include:

• High LDL (bad) cholesterol, which contributes to plaque buildup in the arteries.
• Low HDL (good) cholesterol, reducing the body’s ability to remove excess cholesterol.
• High triglycerides, another blood fat that contributes to cardiovascular disease and pancreatitis.
• Elevated total cholesterol

ICMR-INDIAB programme has already shown that lipid disorders remain one of the concerning health risks. However, the latest study highlights just how serious the problem has become, with nearly 90% of adults exhibiting at least one lipid abnormality.

Also read: US Senator & Trump's Close Ally Lindsey Graham Died Of Aortic Dissection: All About The Fatal Heart Emergency

Why Is India Facing A Cholesterol Crisis?

Factors like rapid urbanisation, sedentary lifestyles, unhealthy diets, obesity and rising diabetes rates are likely contributing to the worsening burden of cholesterol.

Unlike many chronic diseases, dyslipidemia can be managed through early detection and lifestyle change. Doctors recommend the following preventive measures:

• Regular lipid profile screening, especially after age 30 or earlier for high-risk individuals.
• Maintaining a healthy body weight.
• Exercising regularly.
• Eating a diet rich in fruits, vegetables, whole grains and healthy fats while limiting saturated and trans fats.
• Managing diabetes and blood pressure.
• Taking cholesterol-lowering medications such as statins when prescribed.

India has witnessed a steady rise in metabolic disorders over the past two decades, with cases of diabetes, obesity, hypertension and abnormal cholesterol increasingly surging.

Researchers warn that unless preventive measures are strengthened and strict lifestyle changes adopted, the country could face an even greater burden of heart disease and other related disorders in the future.

Climate activist and education reformer Sonam Wangchuk's indefinite hunger strike has entered a critical stage. After 20 days of without food, Wangchuk's condition worsened significantly. The spectacle drew nationwide attention as concerns over his deteriorating health continue to grow.

The protest, which began on June 28 at Delhi's Jantar Mantar, is aimed at demanding accountability over alleged irregularities in national entrance examinations like NEET and broader education reforms.

Wangchuk has experienced substantial weight loss ever since his hunger strike started. Doctors also warned that prolonged fasting could lead to serious complications, including organ involvement.

Sonam Wangchuk's Hospitalisation & 'Chalo Sansad' March

On July 18, Delhi Police shifted Sonam Wangchuk from the protest site to Safdarjung Hospital following medical advice and court-directed health monitoring. The move sparked controversy, with supporters alleging that he was moved to the hospital against his wishes.

According to the hospital, he’s receiving the necessary medical care, and his vital parameters remain stable.

“Sonam Wangchuk is being given the required medical intervention at VMMC & Safdarjung Hospital. His vital parameters are stable at present; however, his blood parameters remain marginally altered, and considering the physiological stress and systemic effects of prolonged fasting, he requires continuous medical care under the close observation of a multidisciplinary team of experts", the hospital's spokesperson said.

Despite being hospitalised, Wangchuk has remained firm on continuing his fast. In a handwritten note that was shared on his official X handle, he urged supporters to participate in the planned "Chalo Sansad" march on July 20.

When Does Hunger Strike Become Medically Concerning?

Also read: Watch: What Really Happens To Your Body After 72 Hours Without Food?

With Wangchuk's health continuing to deteriorate, his protest has renewed public interest in the medical dangers of prolonged hunger strikes.

The deterioration of one's health after a period of prolonged fasting is a medical emergency but it is highly variable.

Dr M Wali, Principal Director, Internal Medicine, Pacific One Health, says, "The timing of health deterioration becoming a medical emergency varies on various factors. It depends on age, existing health parameters before fasting, hydration, medications, environmental conditions and most important whether the person is taking only water or electrolytes. There is no fixed timeline for vitals to deteriorate."

24-72 Hours

In the first three days, the doctor says that the body suffers from spells of hunger, dizziness, and mild drop in blood pressure.

3 to 9 Days

During this period, fluctuations in blood sugar can start. The expert says that during this time, the body relies heavily on stored fats. Weight loss, low blood pressure, slow pulse, dehydration, and electrolytes imbalance start happening too.

10-14 days

Experts say that this is the critical period when serious complications can arise, especially like kidney injury, heart rhythm abnormalities, confusion, and collapse.

According to Dr Anshu Rohtagi, Sr Consultant at Department of Neurology, Sir Ganga Ram Hospital, "After sustained and prolonged complete fasting of couple of weeks, the risk of permanent organ damage and death increases manifold although survival depends on hydration and status of nutrition. Someone refusing both food and water can deteriorate much faster - sometimes in a few days also."

Also read: How Colonialism Continues To Bear An Impact On The South Asian Health Crisis

Another expert says that during this time, certain critical symptoms are evaluated that could cause serious complications.

According to Dr Niraj Tyagi, renowned critical care specialist, "The visiting medical team looks for signs that generally prompt urgent medical evacuations. Some of them are loss of consciousness or inability to stay awake, confusion or delirium, chest pain, abnormal heart rhythm, very low blood pressure causing fainting or shock, persistent low blood pressure, severe dehydration, little or no urine output, dangerous imbalance of electrolytes and kidney or other organs injury."

According to human rights experts, "Whether someone can be shifted to medical facility or treated against their wishes depends on local laws, court orders, and, most importantly, whether the person is in sound mental health to take informed decisions."

Treatment Plan

Dr. Wali explains how the treatment course looks like for someone who has been without food for weeks.

He says, "Once shifted to medical facility, treatment depends on the patient's condition and may include careful rehydration, correction of electrolytes imbalance, continuous cardiac and kidney monitoring, nutritional rehabilitation. Doctors usually monitor potassium, magnesium, and glucose closely during re-feeding."

He adds, "It is important to note that even after recovery, the person may remain medically vulnerable even if they feel well."

A new experimental vaccine targeting one of pancreatic cancer's most common genetic mutations has shown encouraging results in an early-stage clinical trial.

Strong immune responses in most participants were observed, sparking fresh hope against one of the world's deadliest cancers.

About The Study

The Phase I study, published in Cancer Discovery, examined an investigational mutant KRAS-targeted vaccine (mKRAS-VAX) in patients who had undergone surgery for pancreatic ductal adenocarcinoma (PDAC), the most common form of pancreatic cancer.

The trial enrolled 12 patients with resected KRAS-mutant pancreatic cancer who received the vaccine alongside two immune checkpoint inhibitors, nivolumab and ipilimumab, after completing standard treatment.

Researchers observed vaccine-induced T-cell responses in 91.7% of patients, with immune cells remaining detectable for up to two years in some participants.

Importantly, patients who mounted stronger immune responses also appeared to remain disease-free for longer, although the study was not designed to prove that the vaccine directly improves survival.

Also read: Broadcaster Lauren Laverne Shares 'Smoldering Myeloma' Diagnosis After Cancer Recovery

Milestone Results Show Strong Immune Response

According to the researchers, pancreatic cancer has always been difficult to treat because it suppresses immune responses.

"The significant increase in vaccine-generated T-cell responses demonstrates that the immune system can be trained to recognize KRAS-mutant pancreatic cancer," the researchers said, noting that higher T-cell responses were associated with longer disease-free survival.

The researchers said that these findings support continued evaluation of KRAS-targeted vaccination strategies in larger clinical trials.

Also read: Postpartum Breast Cancer May Be Biologically More Aggressive; Here’s Why

Parallel Research Shows Potential Too

The promising study follows another recently published Phase I trial in Cancer Discovery that tested a KRAS-targeted vaccine in individuals at high risk of developing pancreatic cancer.

That study found the vaccine safely stimulated KRAS-specific T-cell responses in about 90% of participants, suggesting such vaccines may eventually help prevent pancreatic cancer in selected high-risk groups.

Dr. Neeha Zaidi, associate professor of oncology at Johns Hopkins University and one of the corresponding authors of the prevention study, said, "Individuals at high risk due to hereditary predisposition or to the presence of a concerning pancreatic lesion detected on imaging usually undergo surveillance to monitor for changes over time."

Also read: Cancer Is Not A Death Sentence Anymore: How Early Detection & Modern Treatment Are Changing Outcomes In Tier-2 Cities

She noted that surgery remains the standard treatment when cancer or high-risk lesions are detected, but recurrence remains common, highlighting the need for preventive strategies.

Elizabeth Jaffee, another author, said, "The goal of this study was to test the safety of the vaccine and induction of durable immune responses."

She added that the clinical trial was built on existing evidence showing KRAS-targeted vaccination could prevent progression of early precancerous lesions in animal .

Importance Of KRAS

KRAS is one of the most frequently mutated cancer-driving genes in pancreatic cancer, with mutations present in roughly 90% of pancreatic ductal adenocarcinomas. These mutations continuously prompt cancer cells to grow and divide.

However, scientists have spent decades trying to develop therapies capable of effectively targeting the protein.

Rather than attacking the cancer directly, the new vaccine teaches the immune system to recognize mutated KRAS proteins as abnormal and launch T-cell attacks against cancer cells.

Pancreatic cancer remains one of the most aggressive cancers worldwide because symptoms often appear only after the disease has spread beyond the pancreas.

While experts caution that the current findings come from an early-stage study, they say the results provide promising evidence that cancer vaccines can successfully activate the immune system against pancreatic tumors.