Heart attacks and strokes are among the leading causes of death globally, with millions suffering from cardiovascular diseases (CVD) every year. There are more than seven million people in the UK alone, with about 100,000 patients experiencing heart attacks annually. However, a group of researchers at University College London (UCL) estimate that one 'polypill' taken daily day could eliminate a majority of these cases dramatically lowering death tolls.

The proposed polypill, a combination of a statin and three blood pressure-lowering drugs, has been under study for over two decades. Experts argue that introducing this pill universally for individuals aged 50 and above could be more effective than the current NHS Health Check, which assesses risk factors every five years for those aged between 40 and 74.

Studies have repeatedly proven the effectiveness of the polypill in preventing CVD. A groundbreaking 2019 study in The Lancet found that five years' use of the polypill cut the risk of heart attack and stroke by a third. In addition, previous modelling analyses have estimated that if given universally to people over 55, the polypill might be able to prevent 80% of heart attacks and strokes.

Today, the NHS Health Check follows a risk-based model in which patients are tested for CVD risk factors and treated with drugs accordingly. Yet, as per UCL's study, this system has serious flaws:

Low Uptake: Just 40% of those eligible for the NHS Health Check choose to have it, leaving a considerable number of at-risk patients undiagnosed and untreated.

Ineffective Prediction of Risk: The majority of heart attacks and strokes happen to people at average risk levels, thus making it challenging to identify the need for intervention effectively.

Limited Effectiveness: Even at maximum take-up, the NHS Health Check programme is predicted to have fewer health impacts compared to a polypill initiative applied to the whole population.

Simplicity and Affordability of the Polypill Strategy

One of the big benefits of the polypill is that it is so easy. In contrast to the existing screening-based model, the polypill scheme would not involve complicated medical tests or lengthy risk assessments. Instead, people reaching 50 would just have to fill out a few questions to determine possible side effects before they were prescribed.

Professor Aroon Hingorani of the UCL Institute of Cardiovascular Science, one of the strongest proponents of this scheme, says:

"Finally, the time is now to do much better on prevention. A population approach would prevent a lot more heart attacks and strokes than is done today with a strategy of trying to target a smaller group only."

Aside from the possible health implications, the polypill is also an economic solution. The drugs used are off-patent, thus cheap to produce and distribute. With the vast economic cost of managing CVD-related illnesses, a preventive model could result in substantial cost-saving for the NHS in the future.

The polypill has been proven to be effective by numerous international trials. In 2019, a randomised trial in rural Iran discovered that participants who took the polypill for five years had a 34% reduced risk of having a heart attack or stroke compared to non-participants.

Likewise, modelling research has indicated that even if only 8% of people aged over 50 took up the polypill regimen, it would still be more beneficial to their health than the NHS Health Check programme.

Is This a Case of Over-Medicalisation?

One of the main objections to the polypill strategy is the suggestion that it might result in the unnecessary medicalisation of a significant proportion of the population. But, it is argued, it should be considered as a preventative measure, not as mass medication.

Professor Sir Nicholas Wald of UCL's Institute of Health Informatics explains:

"Instead of being a 'medicalisation' of a significant proportion of the population, a polypill programme is a prevention measure to prevent an individual from becoming a patient."

He compares it with public health measures like water fluoridation or compulsory seatbelts—interventions that have been shown to have a significant impact in reducing public health danger at low individual cost.

With the evidence in favour of the polypill's effectiveness and viability overwhelming, experts are calling on the NHS to act now. It is their belief that substituting the NHS Health Check with a polypill-based prevention program could be the UK government's flagship policy under its pledge to put disease prevention ahead of cure.

As Professor Hingorani points out, "The status quo is not a justifiable option." With CVD still a major cause of death globally, taking a population-wide polypill approach could be a turning point for preventative medicine, potentially saving thousands of lives annually. The question now is whether the NHS will take up this call and establish a policy with the potential to transform the prevention of cardiovascular disease on a national level.

Children under 5 in India remain at high risk of typhoid infections, hospitalization, and death due to growing antimicrobial resistance (AMR), according to an alarming study, which highlighted the urgent need to control drug resistance in the country.

Typhoid fever is a systemic illness caused by Salmonella enterica serovar Typhi (S. Typhi), and presents a significant health challenge in India.

The modelling study, published in The Lancet Regional Health – Southeast Asia, showed that typhoid fever caused an estimated 4.9 million cases and nearly 8,000 deaths in India in 2023.

However, more concerning was that a large proportion of infections were found resistant to fluoroquinolones — one of the main classes of antibiotics used to treat typhoid. They found that:

• Children aged 5–9 years had the highest number of typhoid fever cases and AMR cases
• Children aged 6 months to 4 years experienced the highest number of hospitalizations and deaths.

"Drug-resistant typhoid fever remains a serious public-health threat in India, with implications beyond national borders," said Dr Vijayalaxmi Mogasale, Joint PhD Candidate at the London School of Hygiene & Tropical Medicine and Nagasaki University.

"Tackling this problem does not lie solely in moving to newer antibiotics, but calls for timely preventive action, including responsible antibiotic use and the introduction of the typhoid vaccine into the national immunization program, prioritizing high-burden age groups and regions," she added.

Also read: Study Links Widespread Use of Antibiotics During COVID To Surge In AMR Cases

Typhoid: AMR A Major Concern In India

In Global Burden of Diseases (GBD) 2021, India contributed to 58 percent of global typhoid fever cases and 48 percent of global deaths.

The new study, including researchers from Christian Medical College in Vellore, estimated that more than two-thirds of typhoid cases in India are resistant to fluoroquinolones. This not only limits treatment options but also increases the risk of complications.

The major drivers of typhoid fever deaths were identified among those with no treatment and hospitalized cases with AMR-related complications. The highest burden of typhoid cases were reported from Delhi, Maharashtra, and Karnataka.

Further, the study found that drug-resistant typhoid infections accounted for at least 87 per cent of India's disease-related economic burden in 2023, the PTI reported.

The total economic burden due to typhoid fever was estimated at Rs 123 billion.

Children under the age of 10 incurred the highest economic burden, contributing to over half of the costs, researchers found.

In addition, they estimated that households bore 91 per cent of expenses, and 70,000 families faced "catastrophic" health expenditure.

A 2024 ICMR report also flagged that more Indians are developing antibiotic resistance against typhoid, pneumonia, and urinary infections. Over 95 percent of Salmonella typhi strains are now resistant to fluoroquinolones, making it difficult to treat infections caused by this bacterium.

Also read: Antimicrobial Resistance Explained: Why Is WHO Calling It A Serious Health Threat?

Typhoid: How Vaccines Can Help

Typhoid fever is a water- and food-borne infectious disease. Major symptoms include

• high fever,
• fatigue,
• headache,
• abdominal pain.

The World Health Organization (WHO) recommends TCV for children from six months of age and for adults up to 45–65 years, depending on the vaccine.

To achieve greater impact, the Lancet researchers suggested implementing:

• A broader catch-up or school-based vaccination campaigns
• controlling the broader strategy of antimicrobial stewardship
• Making improvements in water, sanitation, and hygiene.

The US Centers for Disease Control and Prevention (CDC) has raised concerns about a highly mutated variant of COVID-19 -- BA.3.2 -- which has been reported in at least 23 countries, including 25 states in America.

The BA.3.2 variant was first identified in a respiratory sample in South Africa in November 2024.

The World Health Organization (WHO) has designated BA.3.2 as a Variant Under Monitoring (VUM). It does not boost immunity from previous infection or vaccination.

What makes the BA.3.2 variant special is the “70 to 75 substitutions and deletions in the gene sequence of its spike protein”, according to the CDC’s latest Morbidity and Mortality Weekly Report.

“BA.3.2 represents a new lineage of SARS-CoV-2, genetically distinct from the JN.1 lineages (including LP.8.1 and XFG) that have circulated in the US since January 2024,” said the CDC researchers.

“BA.3.2 mutations in the spike protein have the potential to reduce protection from a previous infection or vaccination,” they added.

What Is The BA.3.2 Variant?

BA.3.2 is a descendant of the Omicron BA.3 lineage. It is genetically distinct from the previously circulating JN.1 lineages (including LP.8.1 and XFG).

BA.3.2 comprises two major branches, BA.3.2.1 and BA.3.2.2. BA.3.2.2 also has substitutions like: K356T, A575S, R681H, and R1162P, the CDC report said.

The first BA.3.2 lineage sequence was detected in a respiratory sample collected on November 22, 2024, in South Africa from a boy aged 5 years.

It was then identified in 2025, in Mozambique (March), the Netherlands (April), and Germany (April). It began to increase in September 2025, with the highest number of detections reported during the week beginning December 7, 2025.

As of February 11, 2026, BA.3.2 had been detected in at least 23 countries.

Between November 2025 and January 2026, the weekly BA.3.2 detections increased and reached approximately 30 percent of sequences reported in three European countries (Denmark, Germany, and the Netherlands).

BA.3.2 In The US

The strain was detected in the US on June 27, 2025, through the CDC’s Traveler-Based Genomic Surveillance program in a participant traveling to the US from the Netherlands.

The first US detection of BA.3.2 in a clinical specimen collected from a patient was reported on January 5, 2026. Since then, the CDC has detected the BA.3.2 variant from

• nasal swabs collected from 4 US travelers,
• clinical samples from 5 patients,
• 3 airplane wastewater samples,
• 132 wastewater surveillance samples from 25 states in the US.
• Till February 11, the strain has been prevalent among 2,579 total genetic sequences.

The CDC stressed the need for “continued genomic surveillance to track SARS-CoV-2 evolution and determine its potential effect on public health”.

BA.3.2 A Variant Under Monitoring

According to the WHO, BA.3.2 demonstrates antigenic drift and reduced neutralization in vitro from previously infected or vaccinated individuals.

However, the global health body noted that currently approved COVID-19 vaccines are expected to continue providing protection against severe disease.

Despite immune evasion, phenotypic data suggest BA.3.2 has reduced infectivity.

It shows resistance to some monoclonal antibodies (cilgavimab, bebtelovimab, sotrovimab) but increased sensitivity to tixagevimab-be, the WHO said.

After the huge success of the first phase of its 100-day TB Mukt Bharat campaign in 2025, India has launched the next phase of a focused and intensified campaign to end tuberculosis — the most infectious disease in the world — in the country.

The campaign was launched by Union Minister for Health and Family Welfare Jagat Prakash Nadda at a national-level event held in Greater Noida to commemorate World TB Day 2026.

He reaffirmed India’s unwavering commitment to eliminating tuberculosis, ahead of the global Sustainable Development Goals target of 2030.

The second phase marks “a decisive, mission-mode push to accelerate progress towards TB elimination”, the Ministry of Health said.

The campaign is expected to “cover 1.58 lakh villages and urban wards, each guided by granular, locally tailored micro-plans, ensuring precision in implementation and measurable outcomes,” it added. The villages and wards were identified using AI-based assessment of 30+ indicators.

“World TB Day 2026 as both a moment of reflection and a renewed call to action in India’s journey towards a TB-Mukt Bharat,” said Nadda, while delivering the keynote address.

The 100-day campaign

The 100-day campaign was first launched on December 7, 2024, and it continued till March 24. It aims to accelerate TB detection, rapid decline in TB incidence, finding of missing cases, reducing mortality, and following a Jan Bhagidari or community approach.

In 2025, the campaign targeted a selected 347 high-priority districts across 33 States/UTs. It was later scaled nationwide and deployed advanced tools such as portable X-rays, AI-enabled diagnostics, and molecular testing.

Nadda noted that the 100-day campaign led to the detection of “nearly 10.9 lakh asymptomatic patients who exhibited no classical symptoms at the time of testing”.

The campaign led to the identification of the “invisible” pool of infection that would otherwise have remained undetected and contributed to continued transmission in the community, the Minister said.

Other key milestones achieved in the fight against TB since December 2024 include:

• screening of vulnerable population – more than 20 Crores
• new TB patients diagnosed - 32,65,215
• asymptomatic patients diagnosed - 10,90,742
• TB preventive treatment initiated - 16,45,493
• Ni-kshay Poshan Yojana paid - 8,36,754
• New Ni-kshay mitras registered - 5,40, 028
• Food Basket distributed - 31, 91, 091.

India Acing Forward In Fight Against TB

In 2024, India notified 26.18 lakh TB cases — the highest so far. TB notification has remained a key area of concern. A total of 67, 933 gram panchayats have achieved the TB-free status, the Ministry

“Over the past decade, India’s TB response has evolved into a transformational, people-centric movement, driven by innovation, equity, and strong political commitment,” Nadda said.

Also read: Tuberculosis in 2026: Why It Still Remains India’s Silent Epidemic

The Minister highlighted key achievements from 2015 to 2024. This includes:

• a 21 percent reduction in TB incidence — from 237 to 187 per lakh population
• a 25 percent decline in TB mortality — from 28 to 21 per lakh population
• treatment coverage increased — 92 percent from 53 percent in 2015
• sharp decline in undetected cases — from >10 lakhs annually to <1 lakh
• treatment success rate increased — 90 percent — higher than the global rate of 88 percent.

• Over 3,000 handheld AI-enabled X-ray units deployed
• NAAT laboratories scaled up to over 9,800
• TB services integrated across 1.8 lakh Ayushman Arogya Mandirs
• Nikshay Poshan Yojana transferred over Rs 4,590 crore to 1.39 crore TB patients since 2018
• Ni-kshay Mitra initiative participation increased to over 7.16 lakh citizen.