Heart attacks and strokes are among the leading causes of death globally, with millions suffering from cardiovascular diseases (CVD) every year. There are more than seven million people in the UK alone, with about 100,000 patients experiencing heart attacks annually. However, a group of researchers at University College London (UCL) estimate that one 'polypill' taken daily day could eliminate a majority of these cases dramatically lowering death tolls.

The proposed polypill, a combination of a statin and three blood pressure-lowering drugs, has been under study for over two decades. Experts argue that introducing this pill universally for individuals aged 50 and above could be more effective than the current NHS Health Check, which assesses risk factors every five years for those aged between 40 and 74.

Studies have repeatedly proven the effectiveness of the polypill in preventing CVD. A groundbreaking 2019 study in The Lancet found that five years' use of the polypill cut the risk of heart attack and stroke by a third. In addition, previous modelling analyses have estimated that if given universally to people over 55, the polypill might be able to prevent 80% of heart attacks and strokes.

Today, the NHS Health Check follows a risk-based model in which patients are tested for CVD risk factors and treated with drugs accordingly. Yet, as per UCL's study, this system has serious flaws:

Low Uptake: Just 40% of those eligible for the NHS Health Check choose to have it, leaving a considerable number of at-risk patients undiagnosed and untreated.

Ineffective Prediction of Risk: The majority of heart attacks and strokes happen to people at average risk levels, thus making it challenging to identify the need for intervention effectively.

Limited Effectiveness: Even at maximum take-up, the NHS Health Check programme is predicted to have fewer health impacts compared to a polypill initiative applied to the whole population.

Simplicity and Affordability of the Polypill Strategy

One of the big benefits of the polypill is that it is so easy. In contrast to the existing screening-based model, the polypill scheme would not involve complicated medical tests or lengthy risk assessments. Instead, people reaching 50 would just have to fill out a few questions to determine possible side effects before they were prescribed.

Professor Aroon Hingorani of the UCL Institute of Cardiovascular Science, one of the strongest proponents of this scheme, says:

"Finally, the time is now to do much better on prevention. A population approach would prevent a lot more heart attacks and strokes than is done today with a strategy of trying to target a smaller group only."

Aside from the possible health implications, the polypill is also an economic solution. The drugs used are off-patent, thus cheap to produce and distribute. With the vast economic cost of managing CVD-related illnesses, a preventive model could result in substantial cost-saving for the NHS in the future.

The polypill has been proven to be effective by numerous international trials. In 2019, a randomised trial in rural Iran discovered that participants who took the polypill for five years had a 34% reduced risk of having a heart attack or stroke compared to non-participants.

Likewise, modelling research has indicated that even if only 8% of people aged over 50 took up the polypill regimen, it would still be more beneficial to their health than the NHS Health Check programme.

Is This a Case of Over-Medicalisation?

One of the main objections to the polypill strategy is the suggestion that it might result in the unnecessary medicalisation of a significant proportion of the population. But, it is argued, it should be considered as a preventative measure, not as mass medication.

Professor Sir Nicholas Wald of UCL's Institute of Health Informatics explains:

"Instead of being a 'medicalisation' of a significant proportion of the population, a polypill programme is a prevention measure to prevent an individual from becoming a patient."

He compares it with public health measures like water fluoridation or compulsory seatbelts—interventions that have been shown to have a significant impact in reducing public health danger at low individual cost.

With the evidence in favour of the polypill's effectiveness and viability overwhelming, experts are calling on the NHS to act now. It is their belief that substituting the NHS Health Check with a polypill-based prevention program could be the UK government's flagship policy under its pledge to put disease prevention ahead of cure.

As Professor Hingorani points out, "The status quo is not a justifiable option." With CVD still a major cause of death globally, taking a population-wide polypill approach could be a turning point for preventative medicine, potentially saving thousands of lives annually. The question now is whether the NHS will take up this call and establish a policy with the potential to transform the prevention of cardiovascular disease on a national level.

A new scientific investigation has drawn attention to alarming levels of uranium in the breastmilk of nursing mothers across six districts in Bihar. The findings suggest possible health risks for infants who depend entirely on breastmilk in their first months.

Published in Scientific Reports, the study is the first to examine uranium contamination in breastmilk from the Gangetic belt of Bihar, a region already known for widespread exposure to arsenic, lead, mercury and other heavy metals.

Researchers collected breastmilk samples from 40 mothers aged 17 to 35 from Bhojpur, Samastipur, Begusarai, Khagaria, Katihar and Nalanda. Each participant gave informed consent, and the team documented breastfeeding habits, child health, and residential history. The work was carried out by scientists from Mahavir Cancer Sansthan & Research Centre (Patna), Lovely Professional University, NIPER-Hajipur and other collaborating institutions.

Breastfeeding Samples Show Uranium In Bihar

The most concerning outcome was that every single sample contained detectable uranium. As per NTDV, the authors noted that “100% of lactating mothers had their breastmilk highly contaminated with uranium.” The concentrations varied, reaching as high as 5.25 μg/L in some cases. Although there is no globally accepted safety limit for uranium in breastmilk, the presence of any radioactive heavy metal in an infant’s only food source raises immediate health worries.

District Wise Readings

Uranium concentrations were not uniform across districts. The data showed the highest average burden in Khagaria, followed by Samastipur, Begusarai, Katihar, Bhojpur and Nalanda. Katihar had the single highest recorded value at 5.25 μg/L, while Khagaria had the highest mean value of 4.035 μg/L. Nalanda showed the lowest average level at 2.354 μg/L. Spatial mapping in the study also indicated a distinct distribution pattern, suggesting local environmental and geological influences.

Can Breastmilk Contaminated with Uranium Affect Newborns?

To assess potential harm, the team estimated uranium intake by infants using Monte Carlo modelling with 10,000 simulations. The analysis suggested that about 70 percent of infants could face non-cancer health effects if exposure continues.

The study stressed that babies are far more vulnerable than adults because their organs are still developing, their body weight is low, and they eliminate toxins less efficiently. While the analysis did not show a cancer risk from the detected levels, the exposure was high enough for researchers to warn about possible kidney damage and other non-carcinogenic effects in infants.

Interestingly, as per NDTV, a senior scientist with the National Disaster Management Authority said the study does not signal a public health threat. According to him, the uranium levels detected in the Bihar samples fall well below the limit set by the World Health Organization.

Is Uranium In Breastmilk Worrisome?

Though uranium is known for its radioactive properties, its chemical toxicity poses a more immediate threat. Since infants absorb heavy metals more easily, uranium exposure in early life may cause long-term issues, including:

• Kidney damage and impaired kidney function

• Problems in neurological development, affecting behaviour and cognition

• Possible increased cancer risk later in life

• Interference with bone, immune and motor development

• The ability to cross the placental and blood-brain barriers, potentially harming brain growth

The study did not test water or food consumed by the participating mothers, but the authors referred to previous research that documented high uranium levels in 273 groundwater samples from Bihar.

Districts such as Supaul, Nalanda and Vaishali recorded extremely elevated levels, far above the WHO guideline of 30 μg/L for drinking water. Since groundwater is widely used for drinking and farming in Bihar, the contamination likely stems from natural geological deposits, excessive groundwater extraction, phosphate fertilisers, industrial waste and inadequately treated sewage. Earlier surveys show that uranium contamination is widespread, with at least 11 districts reporting unsafe concentrations in drinking water,

Should Mothers Stop Breastfeeding Their Newborns?

The researchers make it clear that mothers should not stop breastfeeding because of these findings. They emphasise that breastfeeding remains the healthiest and most beneficial source of nutrition for infants, and should only be discontinued if a doctor advises it. While the uranium levels observed are a cause for concern, the study notes that they are not a reason to halt breastfeeding on their own.

New findings suggest that a common supplement might play a role in lowering the risk of Alzheimer’s disease. Researchers have found that a naturally occurring amino acid may help stop the build-up of harmful plaque in the brain. Alzheimer’s remains the leading cause of dementia and often brings changes in memory, communication and behaviour.

Experts believe the condition begins when certain proteins collect in and around brain cells. One of these proteins, amyloid, can form thick deposits that interfere with how the brain functions. Recent work now indicates that a simple oral supplement may help limit amyloid levels.

A Supplement That May Help Protect The Brain

The study, published in Neurochemistry International, showed that arginine, a naturally present amino acid, could reduce the clumping of amyloid and lessen its damaging effects in animal models of Alzheimer’s.

What Is Arginine?

Arginine, sometimes listed as l-arginine, helps the body build proteins and is found in foods such as meat, fish, nuts, seeds and dairy. It is also available in supplement form. Researchers stressed that the doses used in their experiments were specific to the study and do not match the amounts sold in commercial supplements. Professor Yoshitaka Nagai, who led the research, said the results suggest that arginine has the ability to curb this build-up both in lab testing and in living organisms.

Professor Nagai explained that the discovery is especially encouraging because arginine already has a well-established safety record and is relatively affordable. This combination, he noted, makes it a promising candidate for future therapeutic use. Reports from Science Daily highlight that the animals given oral arginine developed fewer amyloid plaques and showed a drop in insoluble Aβ42 in the brain. These mice also performed better in behavioural assessments and showed reduced activity of inflammatory genes linked to the progression of Alzheimer’s.

How Arginine Affected Brain Changes In Mice

The research team believes that these results may help spark new ideas for preventing Alzheimer’s or slowing its progression. Professor Nagai said that the findings could be useful not only for Alzheimer’s but also for other disorders linked to abnormal protein folding. He added that because arginine is low-cost and already considered safe for general use, it could move into clinical testing more quickly than many experimental drugs. Even so, researchers cautioned that more preclinical work and human-based studies are needed before any firm conclusions can be made about recommended doses or long-term impact.

Signs of Alzheimer’s disease

According to the NHS, early Alzheimer’s often begins with noticeable memory problems. A person in the initial stages may show signs such as:

• Forgetting recent events or conversations

• Misplacing belongings

• Struggling to recall names of common places or objects

• Having difficulty finding the right words

• Repeating questions

• Showing weaker judgement or taking longer to make decisions

• Becoming less adaptable or more resistant to changes

Anyone who notices these changes in themselves or a loved one should consider seeking advice from a GP.

People who are dealing with a particular Covid symptom have been given a cautionary note by the NHS. The way you position yourself while resting or sleeping can actually aggravate how you feel. As cold weather settles over the UK, the chances of picking up seasonal infections such as colds, flu or COVID-19 begin to rise. These viruses thrive in lower temperatures and spread more easily when people spend more time indoors.

For most individuals, Covid clears up within a few days or a couple of weeks without needing specialised care. Because of this, the NHS advises plenty of rest to support recovery. It also recommends staying home and limiting contact with others if you have symptoms and do not feel well enough to go about your usual activities. The health service further offers specific guidance for anyone struggling with a cough.

NHS Issued A Warning For Certain Covid Symptoms

Cough remains one of the most common signs of Covid, especially when it becomes “continuous.” The NHS describes this as coughing repeatedly for more than an hour, or having three or more coughing spells in a single day.

To help ease the discomfort, the NHS advises: “Do not lie on your back if you have a cough – lie on your side or sit upright instead.”

This suggestion is echoed by Dr Elizabeth Rainbolt. In an interview with the Cleveland Clinic, she noted that lying flat on your back can worsen postnasal drip.

Why Sleeping Position Matters When You Have a Cough

For people dealing with a dry cough, resting on your side rather than on your back may help limit irritation. Dr Rainbolt added: “Raising your head is usually the best position for sleep. You can do this by adding an extra pillow or slightly lifting the head of your bed. This keeps drainage from settling at the back of your throat.”

Anyone coping with a persistent cough should speak with a pharmacist to explore available remedies.

Symptoms

Along with coughing, the NHS lists several other signs of Covid, including:

• A high temperature or shivers (chills) – a high temperature means your chest or back feels hot to the touch (you do not need to check it with a thermometer)
• A change or loss in your sense of smell or taste
• Shortness of breath
• Fatigue
• Aches in the body
• Headache
• Sore throat
• Blocked or runny nose
• Poor appetite
• Diarrhoea
• Nausea or vomiting

Covid Recovery Tips From Health Experts

• Make sure you get enough rest to support your body’s recovery.
• Drink plenty of water to stay hydrated; aim for urine that is light yellow or clear.
• Use paracetamol or ibuprofen to ease discomfort if needed.
• A teaspoon of honey may soothe a cough, but never give honey to infants under 12 months.
• For breathlessness, lower the room temperature or open a window to improve airflow.
• Practice slow, controlled breathing: inhale through your nose and exhale gently through pursed lips, like blowing out a candle.
• Sitting upright in a chair can help ease shortness of breath.
• Keep your shoulders relaxed to prevent tension that can worsen breathing.
• Lean forward slightly, supporting yourself with your hands on your knees or a stable surface, to make breathing easier.
• Avoid using fans to cool your room, as they may disperse viral particles.
• Stay calm if you feel breathless, as anxiety can intensify the sensation.