Heart attacks and strokes are among the leading causes of death globally, with millions suffering from cardiovascular diseases (CVD) every year. There are more than seven million people in the UK alone, with about 100,000 patients experiencing heart attacks annually. However, a group of researchers at University College London (UCL) estimate that one 'polypill' taken daily day could eliminate a majority of these cases dramatically lowering death tolls.

The proposed polypill, a combination of a statin and three blood pressure-lowering drugs, has been under study for over two decades. Experts argue that introducing this pill universally for individuals aged 50 and above could be more effective than the current NHS Health Check, which assesses risk factors every five years for those aged between 40 and 74.

Studies have repeatedly proven the effectiveness of the polypill in preventing CVD. A groundbreaking 2019 study in The Lancet found that five years' use of the polypill cut the risk of heart attack and stroke by a third. In addition, previous modelling analyses have estimated that if given universally to people over 55, the polypill might be able to prevent 80% of heart attacks and strokes.

Today, the NHS Health Check follows a risk-based model in which patients are tested for CVD risk factors and treated with drugs accordingly. Yet, as per UCL's study, this system has serious flaws:

Low Uptake: Just 40% of those eligible for the NHS Health Check choose to have it, leaving a considerable number of at-risk patients undiagnosed and untreated.

Ineffective Prediction of Risk: The majority of heart attacks and strokes happen to people at average risk levels, thus making it challenging to identify the need for intervention effectively.

Limited Effectiveness: Even at maximum take-up, the NHS Health Check programme is predicted to have fewer health impacts compared to a polypill initiative applied to the whole population.

Simplicity and Affordability of the Polypill Strategy

One of the big benefits of the polypill is that it is so easy. In contrast to the existing screening-based model, the polypill scheme would not involve complicated medical tests or lengthy risk assessments. Instead, people reaching 50 would just have to fill out a few questions to determine possible side effects before they were prescribed.

Professor Aroon Hingorani of the UCL Institute of Cardiovascular Science, one of the strongest proponents of this scheme, says:

"Finally, the time is now to do much better on prevention. A population approach would prevent a lot more heart attacks and strokes than is done today with a strategy of trying to target a smaller group only."

Aside from the possible health implications, the polypill is also an economic solution. The drugs used are off-patent, thus cheap to produce and distribute. With the vast economic cost of managing CVD-related illnesses, a preventive model could result in substantial cost-saving for the NHS in the future.

The polypill has been proven to be effective by numerous international trials. In 2019, a randomised trial in rural Iran discovered that participants who took the polypill for five years had a 34% reduced risk of having a heart attack or stroke compared to non-participants.

Likewise, modelling research has indicated that even if only 8% of people aged over 50 took up the polypill regimen, it would still be more beneficial to their health than the NHS Health Check programme.

Is This a Case of Over-Medicalisation?

One of the main objections to the polypill strategy is the suggestion that it might result in the unnecessary medicalisation of a significant proportion of the population. But, it is argued, it should be considered as a preventative measure, not as mass medication.

Professor Sir Nicholas Wald of UCL's Institute of Health Informatics explains:

"Instead of being a 'medicalisation' of a significant proportion of the population, a polypill programme is a prevention measure to prevent an individual from becoming a patient."

He compares it with public health measures like water fluoridation or compulsory seatbelts—interventions that have been shown to have a significant impact in reducing public health danger at low individual cost.

With the evidence in favour of the polypill's effectiveness and viability overwhelming, experts are calling on the NHS to act now. It is their belief that substituting the NHS Health Check with a polypill-based prevention program could be the UK government's flagship policy under its pledge to put disease prevention ahead of cure.

As Professor Hingorani points out, "The status quo is not a justifiable option." With CVD still a major cause of death globally, taking a population-wide polypill approach could be a turning point for preventative medicine, potentially saving thousands of lives annually. The question now is whether the NHS will take up this call and establish a policy with the potential to transform the prevention of cardiovascular disease on a national level.

Finger-prick test for Alzheimer's could actually change its diagnosis. An international research trial is exploring if a simple finger-prick blood test could one day help diagnose Alzheimer's disease much earlier and more easily than current methods. The study has involved 1,000 volunteers aged over 60 from the UK, the UK, and Canada, and aims to detect biological markers in the blood linked to the condition.

If the test is successful, it could shift the Alzheimer's diagnosis. The test has the potential to make the diagnosis cheaper, which may not require expensive scans and invasive procedures.

Why Is This Finger-Prick Alzheimer's Test So Important?

Alzheimer's disease does not begin when memory problems become obvious. Research also shows that abnormal proteins linked to the disease, particularly amyloid and tau, can start building up in the brain more than a decade before symptoms appear.

By the time cognitive changes become noticeable, these damage may already occur. This is why such a test is important to ensure that the condition is diagnosed early. New treatments work best in early stages, which makes it more so important.

How Does The Finger-Prick Test Work?

The trial is examining three specific proteins in the blood that have been strongly associated with Alzheimer’s disease. By measuring their levels and concentration, researchers hope to identify whether someone may be at risk, even before symptoms develop.

All volunteers are also undergoing existing gold-standard tests. These include specialized brain scans using radioactive tracers or lumbar punctures to collect cerebrospinal fluid. These methods are accurate but costly, time-consuming, and invasive. As a result, only a small fraction of patients currently receive them.

One of the biggest advantages of the finger-prick test is that it is simple. Unlike traditional blood tests, this test does not require needles, hospital visits or refrigeration. In the future, it could potentially be done at home, with samples mailed to a laboratory for analysis.

Experts say this could dramatically shorten the time it takes to receive an accurate diagnosis. Many families currently wait months or even years, often navigating multiple appointments before getting clear answers.

Participants have also chosen to take a part due to their personal experience with dementia in the families. For them, the possibility of early screening and new treatment is a way to avoid worsening the condition. Participants who have received negative results describe relief, while also recognizing that individual outcomes are just one part of a much larger study. Researchers will only know how effective the test truly is once data from all participants has been analyzed.

What Happens Next?

So far, 883 volunteers have enrolled, with more than 360 completing every test required. The group includes cognitively healthy individuals, people with mild impairment, and those in the early stages of Alzheimer’s. At least a quarter of participants come from under-represented communities. The trial is also expected to run until 2028.

After a brief period of clear sky, and better air quality index levels (AQI), Delhi is again engulfed with thick layer of smog. Delhiites on Monday morning woke up with the AQI of 418, under the 'severe' category. As per the data released by the Central Pollution Control Board (CPCB), the AQI in the ITO area was recorded 434, Rafi Marg at 417, and areas around Swaminarayan Akshardham temple at 455. All under 'severe' category.

Also Read: NHS England Expands Access To Life Saving Prostate Cancer Drug

• Anand Vihar stood at 462
• Ashok Vihar stood at 473
• Bawana stood at 448
• Burari stood at 460
• Chandni Chowk stood at 454
• Dwarka Sector 8 stood at 427
• Mundka stood at 467
• Narela stood at 437
• Punjabi Bagh stood at 434
• RK Puram stood at 439
• Rohini stood at 437
• Wazirpur stood at 472

GRAP IV Reimposed In Delhi

The Commission for Air Quality Management (CAQM) imposed Stage IV of the Graded Response Action Plan (GRAP) on Saturday evening after AQI crossed the 400 mark for the first time in 2026. GRAP-IV is the strictest of all measures, and bans construction activities, along with restrictions on vehicle movement.

What Is Allowed And What Is Not

Under GRAP-IV, all petrol, diesel and CNG stations in Delhi will supply fuel to only vehicles with valid Pollution Under Control Certificate (PUCC).

Vehicles identified through ANPR cameras or other methods and found refuelled without PUCC will be facing penalties.

Verification of the physical certificates or electronic certificates would be done through systems like VAHAN.

Note: These rules do not apply on emergency vehicles on sovereign duty like ambulances, fire tenders and police vehicles. Vehicles carrying essential goods or providing essential services will be exempted too, notified by authorities.

Any vehicle registered outside Delhi and not compliant with BS-VI norms will not be allowed to operate in the city. CNG and electric vehicles, public transport, and vehicles carrying essential goods are exempted.

Trucks or any other carriers that transport construction materials like sand, stones, bricks, cement, ready-mix concrete, debris and similar items, will not be allowed to enter Delhi.

Are Schools Closed Under GRAP-IV?

Under GRAP-IV, physical classes are suspended, and based on previous precedents, educational institutions were directed to shift to online or hybrid learning mode. GRAP-IV restrictions have been reimposed across Delhi and NCR residents, including Gurugram, Faridabad, Ghaziabad, and Gautam Budh Nagar.

Also Read: Delhi Isn't Just Breathing Toxic Air, But Also A Superbug That Resists Antibiotics

Delhi's Air Pollution Continues To Worsen

Delhi is not just breathing toxic air, but also a superbug through its air, which was found in a latest research conducted by the researchers are Jawaharlal Nehru University, published in Nature - Scientific Reports. Apart from the heavy particulate matter or the PM2.5, which are small enough to penetrate through one's bloodstream and cause blockage, Delhi's air also contains airborne bacteria, including staphylococci. The bacteria levels exceed the safety limit by 16-fold as provided by the World Health Organization (WHO).

Will Delhi Use Smog-Eating Surfaces To Deal With Pollution?

The government is pursuing "smog eating" surfaces to deal with the pollution problem in Delhi. While it may sound like a strange thing in India, not to the world. In fact, in the Netherlands these were used to reduce local nitrogen oxide or the NO concentrations in the air, rather than greenhouse gas concentrations.

Smog usually contains a mixture of hydrocarbons, ozone, oxides of nitrogen and sulphur, and particulates. The pollution is caused by both photochemical reactions that involve sunlight, unburned hydrocarbons and nitrogen oxides, along with high concentrations of particulate matter, especially from vehicle exhaust, construction dust and biomass burning.

Read: Explained: What Are Smog-Eating Surface And How Is Delhi Using It To Beat Air Pollution

Environment Minister Manjinder Singh Sirsa announced "smog eating" surface as part of its pollution control plan, for which the government has also signed an MoU with IIT Madras.

The smog eating surfaces will be public surfaces coated with photocatalytic materials like titanium dioxide or TiO2 that is used to degrade pollutants.

Smog contains mainly nitric oxide, nitrogen dioxide, sulphur dioxide, ozone, and particulate matter. When all of these interact with photocatalytic materials, gaseous pollutants convert into less harmful compounds, such as nitrogen oxides become nitrates or decompose into ions. This process is also known as pollutant mineralization.

Jesy Nelson, former Little Mix singer, 34, and her fiancé, Zion Foster welcomed their twins, Ocean Jade and Story Monroe Nelson-Foster were devastated when the doctors broke the news that "they are probably never going to be able to walk, they probably will never regain their neck strength, so they will be disabled". Both the twins were diagnosed with SMA-1, a rare disease, known as the spinal muscular atrophy type 1.

Zion, 27, shared a poem for his eight-month-old warrior little girls. The Sun reported, he said: "They said it’s unlikely you’ll walk, you may not be able to talk, probably won’t be able to hold your head up, that’s what me and Jesy heard – SMA Type 1.

And it became so clear, doctors only go near what they can measure, so what’s certain?

I watch your smiles like sunsets, not promised, but real. I listen to you babble the sweetest melodies, in the moment it makes me wonder, if I keep telling you who I want you to be, what I want you to do, what I expect from you, am I loving you, or am I loving my fear?

If I take you for how God knitted you, just as you are, nothing removed, am I loving you? Am I accepting you?

Story, is your heart okay? Ocean, how’s your mind? I hear strength in your lungs every time you cry, two little warrior girls who already know how to fight.

Honestly, my worry isn’t the milestones, isn’t forcing life to live a different way. My worry is quieter than that, deeper. It’s about accepting you, loving you for who you are right now, without conditions.

No matter what tomorrow brings, and no matter what yesterday was."

What Treatment Jesy Nelson's Daughter Are Undergoing?

Jesy said, "They have had their treatment, thank God. A one-off infusion. That puts the gene back in their body that they don't have. It stops the muscles still working from dying. Any that have gone you can't regain them back."

While she does not reveal the name of the treatment, it is a single dose gene treatment, where patients receive an intravenous adeno-associated virus stereotype 9 carrying SMN complementary DNA encoding the missing SMN protein, as mentions a 2017 study published in The New England Journal of Medicine, or the Zolgensma, a prescribed gene therapy used to treat children less than 2 years old with SMA.

“Now it’s down to constant physio. We’ve been told they’ll probably never walk or regain their neck strength. They’ll probably be in wheelchairs.”

Also Read: Former Little Mix singer Jesy Nelson's Twin Babies Have SMA-1; Signs She Is Asking Other Parents To Look Out For

Jesy Nelson Twins: What Is SMA-1?

SMA-1. a rare disease, known as the spinal muscular atrophy type 1 or the Werdnig-Hoffmann disease is when the muscle weakness appears at birth or within the first six months. This rare condition prevents infants from sitting unassisted and causing severe breathing, swallowing, and sucking difficulties, leading to a poor prognosis without aggressive support. This condition has impacted the twin babies of the former Little Mix singer Jesy Nelson. Her twin babies may never be able to walk. However, she said that her babies will "fight all the odds" after they were being diagnosed with such a rare genetic condition.

Nelson said that there could be some common signs to look out for, which includes floppiness, inability to hold yourself up without support, a "frog-like" positioning of the legs without much movement, and rapid breathing in the tummy.

"If anyone is watching this video and they think they see these signs in their child, then please, please take your child to the doctor, to the hospital, because time is of the essence, and your child will need treatment. And the quicker you get this, the better their life will be," she added.