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Low-dose CT chest scans could help detect pneumonia in at-risk patients while exposing them to only small amounts of radiation, a new study has found. The research, published in Radiology: Cardiothoracic Imaging, shows that ultra-low-dose scans can effectively detect pneumonia in patients with compromised immune systems, enabling doctors to treat the infection before it becomes life-threatening. According to the researchers, these scans expose patients to just 2% of the radiation dose used in a standard CT scan.
"This study paves the way for safer, AI-driven imaging that reduces radiation exposure while preserving diagnostic accuracy,” lead researcher Dr Maximiliano Klug, a radiologist with the Sheba Medical Center in Ramat Gan, Israel, said in a news release. He added that CT scans are the gold standard for detecting pneumonia but there are concerns regarding the risk posed by repeated exposure to radiation. There is a solution- ultra-low-dose CT scan. However, the problem is that these scans can be grainy and hard to read, researchers said.
Study Gives Solution To This
To overcome that, Klug's team developed an AI program that could help "de-noise" low-dose scans, making them sharper and easier to read. Between September 2020 and December 2022, 54 patients with compromised immune systems who had fevers underwent a pair of chest CT scans -- a normal dose scan and an ultra-low-dose scan. The AI program cleaned up the low-dose scan, and then both sets of images were given to a pair of radiologists for assessment. Radiologists had 100% accuracy in detecting pneumonia and other lung problems with the AI-cleaned low-dose scans, but 91% to 98% accuracy in examining the scans that hadn’t been improved through AI, results show.
"This pilot study identified infection with a fraction of the radiation dose," Klug said. "This approach could drive larger studies and ultimately reshape clinical guidelines, making denoised ultra-low dose CT the new standard for young immunocompromised patients.
How Can You Detect Pneumonia?
Pneumonia is a lung infection that causes the air sacs in the lungs to fill with fluid or pus and can be caused by bacteria, viruses, or fungi. The symptoms can range from milk to severe, which includes:
Coughing with or without cough
Fever
Chills
Trouble breathing
Chest pain, especially when breathing deeply or coughing
Sweating or chills
Rapid heart rate
Loss of appetite
Bluish skin, lips, and nails
Confusion.
How to detect Pneumonia in coughing newborns and toddlers?
Pneumonia can severely affect newborns and young children as their lungs are comparatively more sensitive. As per Dr Goyal, young children can cough for various reasons including seasonal infections and tonsillitis, which is very common in this age group. But if they look visibly irritable and have poor sleep patterns, then parents must reach out to an expert. "I am not saying that parents must visit a hospital but any local paediatrician would be able to detect pneumonia in your kid.
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Even as the world is still grappling with the news of a hantavirus and two separate norovirus outbreaks, the Africa Centres for Disease Control and Prevention (Africa CDC) today confirmed that the Ebola virus has resurfaced in eastern Democratic Republic of the Congo for the 17th time.
In a statement, the Africa CDC reported that there are 246 suspected cases and 65 deaths, mainly in the mining areas of Mongwalu and Rwampara, about 100 kilometers north of the provincial capital, Bunia.
While tests are being carried out to identify the strain of the virus, early indications suggest the strain is not the Zaire variant, which has been responsible for several previous outbreaks in the country, the health officials said.
The Ebola Zaire strain was prominent in Congo’s past outbreaks, including the 2018 to 2020 outbreak in the eastern region that killed more than 1,000 people.
Ebola was first discovered in 1976 in the DR Congo. This is the 17th outbreak of the deadly viral disease in the country.
As per preliminary tests conducted at the Institut National de Recherche Biomédicale (INRB) in the country's capital, Kinshasa, the Ebola virus has been detected in 13 of 20 samples analysed, following consultations with DR Congo's Ministry of Health and National Public Institute.
Of the 65 deaths, four were reported among lab-confirmed cases, Africa CDC said.
Additional suspected cases have also been reported in Ituri's provincial capital, Bunia, a densely populated urban centre near the borders with Uganda and South Sudan, raising fears of regional transmission.
All affected communities and at-risk areas have been advised to follow guidelines from the national health authorities.
Also read: More Americans Exposed To Hantavirus; 41 Under Monitoring, Says CDC
As per the WHO, Ebola virus disease (EVD) is a rare but severe illness in humans and is often fatal.
People can get infected with the virus if they touch an infected animal when preparing food, or touch body fluids of an infected person, such as saliva, urine, feces, or semen, or things that have body fluids of an infected person, like clothes or sheets.
Read More: Another Norovirus Outbreak Confirmed Aboard Cruise Ship In France; Over 1,700 People Trapped
Ebola enters the body through cuts in the skin or when one touches their eyes, nose, or mouth. Early symptoms include fever, fatigue, and headache.
It is a highly infectious and transmissible disease; in fact, there have been cases of healthcare workers who have frequently been infected while treating patients with suspected or confirmed Ebola. This occurs through close contact with patients when infection control precautions are not practiced strictly.
Cases of people conducting burial ceremonies, involving direct contact with the body of the deceased, can lead to the transmission of Ebola. Even after the long suffering and recovery, there is a possibility of sexual transmission. Pregnant women who get acute Ebola and recover may still carry the virus in their breastmilk or in pregnancy-related fluids and tissues.
Symptoms include:
According to the WHO, there are two vaccines against the Ebola virus. But both the Merck-developed Ervebo vaccine, administered in one dose, and Johnson & Johnson-developed Zabdeno and Mvabea vaccine, administered in a two-dose regimen, target Zaire ebolavirus.
The Ervebo vaccine is recommended for use in outbreak settings and is currently the only vaccine available in the global stockpile.
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The hantavirus outbreak may no longer be confined to the luxury Dutch cruise ship MV Hondius, with health officials now assessing the possibility of wider exposure. Officials at the US Centers for Disease Control and Prevention (CDC) said that although no cases have been reported in the US so far, the agency is monitoring 41 people for possible exposure.
The 41 includes the 18 people evacuated from the hantavirus-hit ship from Spain’s Canary Islands.
Notably, of the 18 passengers evacuated, two were carried in the plane's biocontainment units out of an abundance of caution — one who tested positive and another considered a suspected case. They were quarantined at a special facility in Nebraska. The remaining 16 are being quarantined in Omaha and Atlanta.
Speaking to CNN from a biocontainment unit at the University of Nebraska Medical Center in Omaha, Dr. Stephen Kornfeld of Oregon said he “feels wonderful” and is not experiencing symptoms.
Spanish officials confirmed that after initially testing positive for hantavirus, Dr. Kornfeld has since tested negative twice for the disease, meaning no Americans currently have the illness, Forbes reported.
CDC Monitoring More People
However, an additional 16 people are being monitored by the CDC.
The new individuals were not on the cruise ship but were passengers on an April 25 flight to Johannesburg and were exposed to someone known to have been infected, said Dr. David Fitter, who is leading the CDC response to the outbreak, according to The New York Times.
Also read: Shocking Study Finds Andes Hantavirus Could Linger In Semen For Years, Pose Transmission Risk
Seven other passengers from the cruise ship had disembarked on April 24 in St. Helena, an island in the Atlantic Ocean, returned to the US on commercial flights, and are being monitored by state health departments.
As of May 14, there were no confirmed hantavirus cases in the United States, Dr. Fitter said.
“Our job is to ensure that we are monitoring and in contact with anybody that might have been on the flight this person had taken,” Dr. Fitter told reporters. The agency is “monitoring all Americans that potentially would have been exposed, whether in the US or abroad, and we have been in contact with them,” he said.
According to the World Health Organization (WHO), 10 people have been affected by the rat-borne virus so far, of whom three have died.
A Dutch couple is believed to have first been exposed to the virus while visiting a birdwatching site in Argentina.
The WHO has confirmed that the Andes strain of hantavirus — the only strain known to spread from person to person — is behind the outbreak.
While all passengers onboard the cruise have been taken care of by health authorities, the virus’ long incubation period remains a serious concern. This means that even asymptomatic individuals could potentially become infectious 6-8 weeks later.
The WHO recommends that people exposed to hantavirus should be:
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The UK is witnessing yet another outbreak of meningitis, with one college student dead and two others infected in Berkshire, according to the UK Health Security Agency (UKHSA).
According to the agency, close contacts of those affected are being offered antibiotics as a precautionary measure.
Also Read: Why Rebranding PCOS As PMOS Could Mark A New Era In Women’s Health
While stressing that the risk to the wider public remains low, the UKHSA confirmed that one case has been identified as Meningitis B (MenB), while further testing is ongoing.
The latest infections come after a small number of meningitis B cases were reported in the Weymouth region in April, followed by a major outbreak in Kent in March that affected more than 30 people and led to the deaths of a sixth-form pupil and a university student.
The young person who died attended The Henley College, according to a local GP surgery.
Authorities are reportedly sharing information about the infection with students and parents at affected schools. The other two cases are believed to be linked to schools in the Reading area. But the officials are yet to disclose the exact link.
Health officials said close contacts of the infected individuals are being offered antibiotics as a precaution.
Read More: Hantavirus Outbreak: Critically Ill French Patient On Artificial Lung Support
GP surgery, the Hart Surgery, based in Henley-on-Thames, stated that it was in contact with the UKHSA due to the college’s location, adding that the agency was “actively contacting those who may be at risk due to a close association with the student involved.”
However, it said anyone whom the UKHSA has not contacted does not require treatment, and students and staff can continue attending the sixth-form college as usual.
“The number of confirmed cases is very low, so there are currently no plans for a local emergency meningitis vaccination programme,” it added.
Also read: UK Reports Meningitis Outbreak Among School Children: All You Need To Know
Meningitis is a serious medical condition that affects the protective membranes covering the brain and spinal cord, known as the meninges. Fever is often considered one of the classic symptoms, although it may not always be present.
Understanding the symptoms, causes, and treatment options is important for early diagnosis and timely medical care.
“Anyone can get meningitis, and around 300 to 400 cases of meningococcal disease are diagnosed in England every year. It is most common in babies, young children, teenagers, and young adults," said Dr Rachel Mearkle, a consultant in health protection at the UKHSA.
“It needs to be treated quickly, so it is important to know the signs and symptoms. They can appear in any order and may not all be present, so seek rapid medical attention if there is ever any concern," she added.
The expert noted that "meningococcal meningitis requires very close contact to spread, and large outbreaks such as the one recently seen in Kent are thankfully rare."
“Meningococcal disease does not spread easily, and the risk to the wider public remains low.”
Health officials urged the public to remain alert to the warning signs of meningococcal meningitis. Common symptoms include:
“If the disease is suspected, immediate medical attention should be sought, as it can progress rapidly,” the officials said. While antibiotics provide the quickest short-term protection, vaccines offer longer-term protection.
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