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Low-dose CT chest scans could help detect pneumonia in at-risk patients while exposing them to only small amounts of radiation, a new study has found. The research, published in Radiology: Cardiothoracic Imaging, shows that ultra-low-dose scans can effectively detect pneumonia in patients with compromised immune systems, enabling doctors to treat the infection before it becomes life-threatening. According to the researchers, these scans expose patients to just 2% of the radiation dose used in a standard CT scan.
"This study paves the way for safer, AI-driven imaging that reduces radiation exposure while preserving diagnostic accuracy,” lead researcher Dr Maximiliano Klug, a radiologist with the Sheba Medical Center in Ramat Gan, Israel, said in a news release. He added that CT scans are the gold standard for detecting pneumonia but there are concerns regarding the risk posed by repeated exposure to radiation. There is a solution- ultra-low-dose CT scan. However, the problem is that these scans can be grainy and hard to read, researchers said.
Study Gives Solution To This
To overcome that, Klug's team developed an AI program that could help "de-noise" low-dose scans, making them sharper and easier to read. Between September 2020 and December 2022, 54 patients with compromised immune systems who had fevers underwent a pair of chest CT scans -- a normal dose scan and an ultra-low-dose scan. The AI program cleaned up the low-dose scan, and then both sets of images were given to a pair of radiologists for assessment. Radiologists had 100% accuracy in detecting pneumonia and other lung problems with the AI-cleaned low-dose scans, but 91% to 98% accuracy in examining the scans that hadn’t been improved through AI, results show.
"This pilot study identified infection with a fraction of the radiation dose," Klug said. "This approach could drive larger studies and ultimately reshape clinical guidelines, making denoised ultra-low dose CT the new standard for young immunocompromised patients.
How Can You Detect Pneumonia?
Pneumonia is a lung infection that causes the air sacs in the lungs to fill with fluid or pus and can be caused by bacteria, viruses, or fungi. The symptoms can range from milk to severe, which includes:
Coughing with or without cough
Fever
Chills
Trouble breathing
Chest pain, especially when breathing deeply or coughing
Sweating or chills
Rapid heart rate
Loss of appetite
Bluish skin, lips, and nails
Confusion.
How to detect Pneumonia in coughing newborns and toddlers?
Pneumonia can severely affect newborns and young children as their lungs are comparatively more sensitive. As per Dr Goyal, young children can cough for various reasons including seasonal infections and tonsillitis, which is very common in this age group. But if they look visibly irritable and have poor sleep patterns, then parents must reach out to an expert. "I am not saying that parents must visit a hospital but any local paediatrician would be able to detect pneumonia in your kid.
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The US and European Union are closely monitoring a suspected case of pneumonic plague in Russia’s Siberian region of Irkutsk after the death of a 28-year-old laboratory worker at an anti-plague research institute.
Nearly 200 people who may have had contact with the woman have reportedly been placed under medical observation. However, Russian authorities have not confirmed plague.
The woman, identified in reports as Darya Shipilova, worked at the Irkutsk Anti-Plague Research Institute. Reports said she may have accidentally broken a test tube containing Yersinia pestis while collecting samples on September 25.
Russia’s consumer safety watchdog, Rospotrebnadzor, said her diagnosis was “pneumonia of unknown etiology.” Expanded testing did not identify microorganisms associated with her professional activities.
Rospotrebnadzor said the sanitary and epidemiological situation in Irkutsk and Shelekhov remained stable and that special measures had been implemented following her death.
Also read: Russia Plague Outbreak: Lab Worker Dies Of 'Unknown Infection' After Suspected Exposure
The European Commission said it was “monitoring very closely” reports of the laboratory incident.
“We are aware of the reports concerning the laboratory incident in Russia, seemingly involving a pathogen causing plague,” European Commission spokesperson Eva Hrncirova said.
She said the Commission was in contact with the European Centre for Disease Prevention and Control and stressed that timely and transparent reporting and access to reliable epidemiological and laboratory findings are essential.
The EU also said it has strengthened its preparedness for health emergencies since the Covid-19 pandemic.
The US State Department said it was monitoring the reports in coordination with the CDC and other agencies.
CDC officials said many details of the incident remain unconfirmed and urged Russian authorities to share accurate information promptly and transparently. They noted that plague is a known and treatable disease, with common antibiotics particularly effective when treatment begins early, and that cases occur naturally in several parts of the world.
US officials also urged Russia to “share accurate information quickly and openly.” Secretary of State Marco Rubio said the situation was “not cause for alarm” but was a reason for focus and continued monitoring.
Read More: Russia Plague Scare: Could It Trigger A New Pandemic? Experts Explain
WHO said it was aware of the reports and was working to verify the details with Russian health authorities, including laboratory results, contact tracing and the health status of contacts.
Based on unofficial information available, WHO said the public-health risk to the general population appeared low, while noting that the assessment could change as more information becomes available, POLITICO reported.
READ: ‘American Covid’ Strain Drives 50% Surge in UK Hospital Admissions: XFG Symptoms to Know
Pneumonic plague is caused by Yersinia pestis and can spread directly between people through respiratory droplets.
However, a suspected case does not mean an outbreak or pandemic is underway. Rapid diagnosis, isolation, contact tracing and prompt antibiotic treatment would be critical if plague is confirmed.
“Transparency, rapid diagnosis and effective contact tracing would be the most important factors in managing an outbreak,” said Dr Richard Hirschson, a specialist general physician at Sydney Adventist Hospital.
In a post on social media platform X, the expert said that a local laboratory exposure would not necessarily translate into global spread. He added isolation and preventive antibiotic treatment for exposed contacts could help limit transmission if pneumonic plague were confirmed.
Plague is caused by Yersinia pestis, a bacterium generally found in small mammals and their fleas.
Pneumonic plague occurs when the infection affects the lungs and is the form most capable of spreading directly between people.
It can become rapidly life-threatening without treatment, but plague is treatable with antibiotics when diagnosed and treated promptly.
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More than two hours of daily screen time could be associated with around 2.8 million healthy years of life lost to depression and 240,000 healthy years lost to obesity worldwide each year, according to a new three-paper series published in The Lancet.
However, the authors stressed that these are illustrative estimates, not precise measurements of the global health burden, because the certainty of the underlying evidence is low.
"Our global projections of how many healthy years could be lost to depression and obesity linked to excessive screen time are intended to be illustrative of the possible scale of harm," said Dr. Falk Müller-Riemenschneider of the National University of Singapore. "They should not be taken as an accurate measurement of harm."
The series, authored by 13 global experts, argues that simply limiting screen time may not be enough to protect children and young people from digital harms.
Also read: US Surgeon General Issues Advisory To Limit Children's Screen Time
The experts analyzed 121 reviews covering around 9 million people under 25.
They found consistent associations between problematic digital media use — defined as addiction-like patterns rather than simply time spent online — and:
The review also found some potential benefits. Moderate digital media use was associated with higher well-being, while active video game use was associated with higher well-being and healthier lifestyles.
The authors therefore argue that what young people do online, how platforms are designed and how they are governed may matter as much as how long they spend online.
Read More: Can 'Eye Strain' Lead To Brain Cancer? Experts Explain
Features such as infinite scroll, autoplay and personalized recommendation feeds are designed to capture attention and collect data, the authors said.
"Most digital platforms are designed by companies to capture attention and collect data, not to protect health," said Dr. Jay Shaw of the University of Toronto.
He added that more research is needed into how specific platform features influence digital media use rather than focusing only on time spent online.
Series chair Professor Ilona Kickbusch said governments must make children's health and online safety a global policy priority.
"Governments have let technology companies write their own rules, leading to business models built to capture attention and collect data, with health treated as an afterthought," she said.
The authors call for coordinated action by technology companies, governments and international bodies rather than relying on a single intervention such as age limits.
Their recommendations include:
"A key recommendation of our series is that governments should require technology companies to share data on how their features affect users' health with vetted public-interest researchers," said series author Louise Holly.
The series also included a Youth Advisory Group of six young adults aged 23 to 30.
"The health risks and harms associated with digital systems are preventable," said Dr. Salman Fitrat Khan of India. "Governments shouldn't wait for 'perfect' evidence before acting for our generation and the ones coming after us."
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A suspected plague case linked to the death of a lab worker at an anti-plague research facility in Russia has sparked questions about whether the incident could pose a wider pandemic threat.
However, Russian authorities have not confirmed plague. Russia's consumer safety watchdog, Rospotrebnadzor, said the woman's diagnosis was “pneumonia of unknown etiology.” Expanded testing of samples taken from her did not identify microorganisms associated with her professional activities, the agency said.
Nearly 200 people who may have come into contact with her remain under medical observation, but authorities have reported no symptoms or positive test results among those monitored.
Experts say comparisons with COVID-19 should be treated cautiously because pneumonic plague and viral respiratory diseases behave very differently.
Dr Simon Clarke, an expert from the University of Reading, said pneumonic plague is caused by Yersinia pestis, the bacterium responsible for plague.
“Pneumonic plague is particularly serious because it means the infection has reached the lungs and is nearly always fatal if not treated promptly,” said Clarke, associate professor in cellular microbiology in the School of Biological Sciences at varsity.
Unlike bubonic plague, which is commonly associated with infected flea bites, pneumonic plague can spread between people through respiratory droplets during close contact. But there is an important difference from diseases such as COVID-19.
“Unlike many viral respiratory diseases, plague is caused by bacteria and is generally treatable with antibiotics if identified quickly,” Clarke said, in a post on the University's website.
Pneumonic plague can spread from person to person, making rapid identification and contact tracing important. But that does not mean every suspected case carries pandemic potential.
Clarke said more information is needed to determine whether the Russian incident represents an isolated case, an occupational exposure or evidence of wider transmission.
“Transparency, rapid diagnosis and effective contact tracing would be the most important factors in managing an outbreak,” he said.
Dr Richard Hirschson, a specialist general physician at Sydney Adventist Hospital, said “a local Russian lab leak is a local issue, it will not become a global pandemic”.
In a post on social media platform X, he said isolation and preventive antibiotic treatment for exposed contacts can help limit transmission if pneumonic plague is confirmed.
Read More: Exclusive: From IPL To Olympics — How Sport Became A Marketing Tool For Junk Food And Sugary Drinks
Dr Krutika Kuppalli, an infectious disease specialist and Associate Professor in the Department of Internal Medicine at University Texas Southwestern Medical Center, urged caution over the growing speculation.
“But right now, we have an unexplained death from pneumonia—not confirmation of plague and certainly No evidence of a plague outbreak,” Kuppalli said on X.
“It’s appropriate to watch closely and ask questions. It’s not helpful to fill gaps in information with speculation and sensationalism. Good outbreak response starts with the same thing every time: -- follow the evidence,” she added.
Kuppalli also stressed the importance of public health preparedness in responding to emerging infectious threats.
“Infectious disease threats don’t follow political calendars,” she said. “This is why public health matters and why weakening our surveillance, expertise and response capacity should concern everyone. Pathogens aren’t political. Preparedness matters.”
As of now, there is no confirmed evidence of a plague outbreak or sustained person-to-person transmission linked to the Russian case.
The immediate priority is to determine what caused the woman's pneumonia while continuing to monitor potential contacts.
Even if plague is eventually confirmed, experts say its bacterial nature, antibiotic sensitivity and transmission pattern make it fundamentally different from the respiratory viruses that can spread silently and extensively through populations.
For now, the evidence supports close surveillance and investigation—not a conclusion that a new pandemic is emerging, the experts said.
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