Credit: Canva
Low-dose CT chest scans could help detect pneumonia in at-risk patients while exposing them to only small amounts of radiation, a new study has found. The research, published in Radiology: Cardiothoracic Imaging, shows that ultra-low-dose scans can effectively detect pneumonia in patients with compromised immune systems, enabling doctors to treat the infection before it becomes life-threatening. According to the researchers, these scans expose patients to just 2% of the radiation dose used in a standard CT scan.
"This study paves the way for safer, AI-driven imaging that reduces radiation exposure while preserving diagnostic accuracy,” lead researcher Dr Maximiliano Klug, a radiologist with the Sheba Medical Center in Ramat Gan, Israel, said in a news release. He added that CT scans are the gold standard for detecting pneumonia but there are concerns regarding the risk posed by repeated exposure to radiation. There is a solution- ultra-low-dose CT scan. However, the problem is that these scans can be grainy and hard to read, researchers said.
Study Gives Solution To This
To overcome that, Klug's team developed an AI program that could help "de-noise" low-dose scans, making them sharper and easier to read. Between September 2020 and December 2022, 54 patients with compromised immune systems who had fevers underwent a pair of chest CT scans -- a normal dose scan and an ultra-low-dose scan. The AI program cleaned up the low-dose scan, and then both sets of images were given to a pair of radiologists for assessment. Radiologists had 100% accuracy in detecting pneumonia and other lung problems with the AI-cleaned low-dose scans, but 91% to 98% accuracy in examining the scans that hadn’t been improved through AI, results show.
"This pilot study identified infection with a fraction of the radiation dose," Klug said. "This approach could drive larger studies and ultimately reshape clinical guidelines, making denoised ultra-low dose CT the new standard for young immunocompromised patients.
How Can You Detect Pneumonia?
Pneumonia is a lung infection that causes the air sacs in the lungs to fill with fluid or pus and can be caused by bacteria, viruses, or fungi. The symptoms can range from milk to severe, which includes:
Coughing with or without cough
Fever
Chills
Trouble breathing
Chest pain, especially when breathing deeply or coughing
Sweating or chills
Rapid heart rate
Loss of appetite
Bluish skin, lips, and nails
Confusion.
How to detect Pneumonia in coughing newborns and toddlers?
Pneumonia can severely affect newborns and young children as their lungs are comparatively more sensitive. As per Dr Goyal, young children can cough for various reasons including seasonal infections and tonsillitis, which is very common in this age group. But if they look visibly irritable and have poor sleep patterns, then parents must reach out to an expert. "I am not saying that parents must visit a hospital but any local paediatrician would be able to detect pneumonia in your kid.
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Women, young ones and ones holding their babies, along with some men lined up on the outskirts of Zimbabwe's capital Harare for the injections of a new HIV prevention drug. The country launched it on Thursday. This drug needs to be administered only twice a year.
Zimbabwe is a country where HIV led to tens of thousands of deaths in the last two decades. It is the first country to roll out lenacapavir, which is a long-acting drug that authorities have put their hopes on to slow down the HIV infection.
Clinical studies have demonstrated near-total protection for the drug and has been described as a 'turning point' for high risk groups by many experts. However, many have warned that its broad impact would require overcoming funding constraints, infrastructure gaps and the challenge of keeping patients engaged.
Immunologist at Emory University Rama Rao Amara, calls it a "wonder drug". The drug, known as lenacapavir has been approved by the Food and Drug Administration (FDA) and is made by Gilead Sciences.
In 2021, FDA approved injectable form of PrEP medication called cabotegravir, however, this required patients to take it in every two months. This was also an intramuscular dose that healthcare providers were to administer into the buttocks.
What changes with lenacapavir is its easy administration. Each dose lasts longer compared to other medications and requires to be administered twice a year.
Read: 12.4 Lakh HIV Tests In Haryana Detect 5,877 Cases
The limitation with lenacapavir is its price tag of more than $28,000 per person per year. Carmen Pérez Casas, a senior strategy leader at Unitaid, a global health initiative based in Geneva, Switzerland said, "This is unaffordable. We need to get somewhere close to what previous options cost."
However, there is hope as the researchers published an analysis in The Lancet HIV that suggested generic versions of this drug could cost a person $25 per year.
At the Zimbabwe launch, Constance Mukoloka, a sex worker, was among the first beneficiaries of this roll out which has happened by donor-support across 10 African countries, as reported by PBS News.
"I am safe, I can work with confidence now," said the 27-year-old sex worker. "When I took tablets, customers would see a container of pills and leave. They would never return due to fear," she said. "They couldn't tell the difference between PrEP and treatment drugs. With the work we do, that stigma costs you money."
Daily oral PrEP has been offered in Zimbabwe for years, along with condoms, vaginal rings and shorter-acting injections. However, sticking to the regimen has been difficult, especially for people dealing with stigma or irregular daily routines.
"I work in beer halls looking for clients. Sometimes I would get drunk and forget to take my drugs," Mukoloka said. "Sometimes I would work all night and not have time. Some clients refuse protection. They say ... 'Why should I use protection when I have paid?'"
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Mexico has reported more than 2,700 new cases of measles so far this year, as per the government data. Most of these infections have been detected among infants and young children. Not too far away, in the US, as per the Centers for Disease Control and Prevention (CDC) data, 900 new cases have been confirmed.
However, unlike in the 1990s, the Secretary of Public Education in Baja California Sur, Alicia Meza Osuna, clarified that it is not a requirement to present the complete vaccination schedule for children to attend schools. However, in the Mexican city of Cabo San Lucas, specific health measures are being taken.
In the 1990s, the Ministry of Health (SSA) and the Ministry of Public Education (SEP) required that children be protected against diseases such as measles, polio, rubella, tetanus, diphtheria and tuberculosis before entering preschool or primary school, as part of the health prevention policies. However, at present, as Alicia Meza Osuna stated, "It is not a requirement to enroll children in school to present their vaccination card. Under no circumstances is it a requirement to present a complete vaccination schedule for a child to attend school."
Measles, also known as rubeola, is an extremely contagious viral illness that typically causes high fever, cough, runny nose, red and watery eyes, and a characteristic rash that begins on the face and spreads downward across the body. It spreads through respiratory droplets and can lead to severe and sometimes fatal complications, including pneumonia and inflammation of the brain known as encephalitis.
Although it is preventable through the safe and effective MMR vaccine, measles remains a serious threat in many regions. There is no specific cure, and treatment focuses on managing symptoms, according to the Cleveland Clinic.
Measles has a high transmissibility, and high measles immunity levels are required to prevent sustained measles virus transmission.
This is why herd immunity for measles could be easily breached.
It easily spreads from one infected person to another through breathes, coughs or sneezes and could cause severe disease, complications, and even death.
The most unique symptom or the early sign of measles in the Koplik spots. These are tiny white dots that look like grains of salt on red gums inside the cheeks that appear before the red rash starts to appear on a person's face and then the body.
Read: Unique Symptoms Of Measles In 2026 And How Long Does The Infection Last?
Furthermore, the symptoms of measles are also characterized by the three Cs:
The progression of the symptom comes in two stages, first is the prodromal stage or Days 1 to 4, where one would notice high fever, cough, runny nose, red and watery eyes, sore throat, fatigue, and Koplik spots.
The second stage is called the rash stage or the days 5 to 10 or even more where rash start to appear on the hairline, and then it runs down the body. It lasts for several days and fades in the same order.
The first symptoms, notes the Centers for Disease Control and Prevention (CDC), appear 7 to 14 days after a measles infection. Often, it could also lead to ear infection, or even diarrhea. Though these complications happen in every 1 in 10 children or individual with measles.
Credits: IANS
Union Health Minister JP Nadda launched indigenously manufactured tetanus and adult diphtheria (Td) vaccine at the Central Research Institute in Himachal Pradesh's Kasauli on Saturday. The formal launch of the Td vaccine will now include the vaccine under the Universal Immunisation Programme (UIP). The Central Research Institute will supply 55 lakh doses to the UIP by April. The production is also expected to scale up progressively in subsequent years to further strengthen the Central Government's Universal Immunisation Programme, said Nadda.
Nadda also congratulated the scientists, technical experts and staff of the Central Research Institute Kasauli at the gathering, and described the launch Tb vaccine as a momentous and historic occasion. He also stated that the launch marked a significant step towards safeguarding national health security and strengthening India's public health infrastructure.
The minister also noted that the government under the leadership of Prime Minister Narendra Modi, set clear targets for achieving self-reliance in the health and pharmaceutical sectors. Nadda also said that the launch of the indigenously manufactured Td vaccine represents a concrete step towards the vision of Atmanirbhar Bharat in health and medicine.
He also highlighted the nation's global standing. He said that the minister also stated that India is widely recognized as the "pharmacy of the world" and is among the leading vaccine manufacturers globally.
He also said that India has achieved Maturity Level 3 in the World Health Organization's (WHO) global benchmarking of regulatory systems, reflecting the robustness of its vaccine regulatory framework. Institution like CRI, said Nadda, have also played a major role in achieving these standards.
Read: After Coldrif, WHO Bans 2 More Drugs, But This Is Not the Only Death from Indian Cough Syrup
The Union Health Minister said that historically, vaccines and medicines took decades to develop. The tetanus vaccine required years of global research, tuberculosis drugs evolved over nearly 30 years, and the Japanese Encephalitis vaccine took close to a century of scientific effort.
In contrast, during the COVID 19 pandemic, India developed two indigenous vaccines within nine months and administered more than 220 crore doses, including boosters. He added that vaccination certificates were issued digitally, reflecting the country’s expanding use of technology in public health delivery.
Highlighting international cooperation, he noted that under the Vaccine Maitri initiative India supplied vaccines to nearly 100 countries, with 48 receiving them free of cost. Public sector institutions such as the Central Research Institute also strengthened the country’s ability to meet both domestic and global demand.
The minister further said the Central Research Institute became the first government facility to manufacture vaccines under Good Manufacturing Practices standards, marking a major step in modernizing public sector vaccine production.
He described the Universal Immunisation Programme as the world’s largest vaccination drive. It currently provides 11 vaccines protecting against 12 preventable diseases, with significant contributions from the institute.
Every year about 2 to 2.5 crore children are born and a similar number of women become pregnant. From pregnancy registration onward, beneficiaries are tracked through digital platforms such as U WIN. Expectant mothers receive five antenatal check ups including at least one by a specialist, and monitoring continues until the child turns 16 years old, covering 27 doses.
The annual immunization cohort includes nearly 5 crore beneficiaries, around 2.5 crore pregnant women and 2.5 crore children. Due to systematic tracking and sustained immunization efforts, vaccine coverage in the country has reached nearly 99 per cent.
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