A new study has found that a combination of two drugs could enhance the immune system to treat one of the most common types of cancer in the world, bowel cancer. Also known as colorectal cancer, despite its widespread presence, the treatment options for this condition are limited. What the study specifically found was that this procedure could shrink the tumours caused by this condition by around 60%.

What Are The Drugs Involved

The trial involved the use of two immunotherapy drugs, botancilimab and balstilumab. It is a monoclonal antibody that works to stimulate the body's immune system to attack cancer. The study is a rather significant find, as it’s the first time that a consistent and durable response to immunotherapy has been reported in patients with solid MSS mCRC tumours.

The study was divided into several phases for more than 6 months. In the US trial, around around 101 patients with microsatile stable metastatic colorectal (MSS-mCRC) tumours showed a decrease . Around 61% of the patients experienced tumour shrinkage or stabilization after combined treatment with votancilumab and balstilumab. When it comes to downsides, diarrhea and fatigue were found to be the most common side effects or side effects of this drug.

These results are interesting and open to exploration. To date, immunotherapy has not been effective in patients with CNS-mCRC tumors. This study demonstrates the potential of the combination of botenlimab and balstilimab in the treatment of CNS mCRC, providing new hope for people diagnosed with colon cancer.

What Could This Mean For Bowel Cancer Treatment In The Future

The study is currently in the final stages of clinical trials, and the US Food and Drug Administration (FDA) hopes to quickly gain approval for its use because of the importance of this area that affects many people. The efficiency shown demonstrates the potential of botansilimab to contribute to broad antitumor immunity.

All in all, the combination of botensilimab and balstilimab represents a promising new direction in the treatment of colorectal cancer. This breakthrough could improve conditions for many patients worldwide and lights a new hope in the fight against this common disease. The results of this study show the effectiveness of immunotherapy in this field and how its potential to transform cancer treatment can only grow in the years to come.

As part of the New Delhi Declaration adopted at the 18th BRICS Summit in Delhi, world leaders are calling for a stronger focus on obesity and non-communicable diseases. The dialogue mainly focused on healthy lifestyles, combatting sedentary lifestyles, and early intervention to prevent obesity.

The New Delhi Declaration endorsed the BRICS Mission for Healthy Lifestyle, which included a 2026–2029 roadmap for promoting healthier living across member countries. The initiative is set to focus on technical cooperation, ensuring best practices and coordinated awareness efforts around obesity and other NCDs.

For India, as the challenge extends beyond telling people to “eat better and exercise more”, the declaration stressed that there is dire need of government and society-level active approach to tackle the burden of chronic lifestyle disorders.

With long working hours, prolonged sitting, irregular meals and increasingly sedentary routines, preventing NCDs may need major changes in how people work and live.

BRICS Focuses On Obesity And NCDs

NCDs include disorders like heart disease, stroke, diabetes, cancer and chronic respiratory diseases. They are driven by a combination of genetic, physiological, environmental and behavioural factors.

The World Health Organization identifies four major modifiable behavioural risk factors: unhealthy diet, physical inactivity, tobacco use and harmful alcohol consumption.

These can contribute to metabolic problems including obesity, high blood pressure, raised blood glucose and abnormal cholesterol.

WHO estimates that 31% of adults globally were insufficiently physically active in 2022. Physical inactivity increases the risk of cardiovascular disease, diabetes, stroke and several cancers.

Also read: As India Faces Flu Vaccine Shortage Amid H1N1 Surge, ICMR Recommends Alternative: Expert Explains If You Should Take It

How Could The BRICS Mission Translate Into Action?

The new push for lifestyle changes signals a shift from treating NCDs after they develop towards preventive and promotive healthcare involving governments, workplaces, healthcare systems and communities.

Dr Paras Agarwal, Director - Diabetes, Obesity & Metabolic Clinic, CK Birla Hospital, Gurgaon, spoke to HealthandMe about the global push for obesity prevention and promotion of healthy lifestyle.

Dr Agarwal says, "BRICS recognising obesity as a major global public health challenge is a significant step, because obesity is not a cosmetic issue but a metabolic one, closely tied to insulin resistance, diabetes, hypertension and heart disease. Globally, this signals that prevention deserves the same urgency as treatment."

The diabetes specialist said that it is the need of the hour for Indians as it is currently carrying the burden of invisible metabolic risk.

He added, "For India, it carries an added layer: many people with a normal BMI still carry hidden abdominal fat and real metabolic risk."

The expert did not fail to point out the difference between policy building and implementing meaningful systems in place to achieve desired outcomes.

He said, "The real measure of this recognition's success will be whether it translates into accessible screening, sustainable lifestyle support and earlier intervention, rather than remaining a policy statement alone."

Also read: Can India Prevent Rabies Deaths By Vaccinating Dogs? Lancet Study Says Kerala May Reach Near-Zero Deaths In 3 Years

Sedentary Lifestyle Is The Silent Killer

India's growing desk workforce is facing a major health risk. Prolonged sitting could directly contribute to obesity and a number of metabolic and cardiovascular health challenges.

Sedentary behaviour teamed with uncontrolled calorie intake can contribute to weight gain and reduced insulin sensitivity, making it harder for the body to regulate blood glucose. Over time, people at higher risk can progress from normal glucose levels to prediabetes and eventually type 2 diabetes.

These chronic lifestyle disorders can be curbed only when timely preventive action is taken.

It is important to break up long periods of sitting with brief movements like walking during breaks, taking stairs or stretching between meetings, can make physical activity more achievable.

Regular aerobic exercise and strength training remain extremely important, depending on an individual's health and physical ability.

Prevention also includes right food choices, sleep, stress management and timely screening. WHO also recommends adults aged 18–64 get 150–300 minutes of moderate-intensity aerobic activity per week, along with strength training.

Besides obesity and NCDs, the BRICS declaration also focused on mental well-being, including a BRICS Training Hub Network and Centres of Excellence, with NIMHANS as the coordinating centre.

The United States has declared that its largest cyclosporiasis outbreak is finally over. According to reports, contaminated iceberg lettuce was associated with nearly 13,000 infections across 21 states.

The outbreak caused 12,883 reported illnesses, 570 hospitalisations and two deaths in Michigan, according to the US Centers for Disease Control and Prevention (CDC).

While health officials say there is no longer a risk from the recalled lettuce, the investigation into how the parasite contaminated the food in the first place is still ongoing.

Why Cyclosporiasis Outbreak Source Is Still Not Known?

The outbreak was traced through investigations linked to iceberg lettuce sourced from central Mexico by Taylor Farms de Mexico.

The FDA said the investigation included people who reported eating processed iceberg lettuce served or purchased at different locations, including Taco Bell. The agency eventually converged on Taylor Farms as the common supplier and the company recalled the affected lettuce in July.

The FDA has now completed onsite inspections and sample collection at lettuce farms and the processing facility in Mexico. But, lab analysis of those samples is yet to be carried out.

This means investigators know which food was linked to the outbreak, but have not yet determined exactly where or how Cyclospora entered the lettuce supply chain.

Also read: Cyclospora to Alzheimer’s: Trump Administration Scales Back Key Health Research

What Is Cyclospora And How Does It Make You Sick?

Cyclospora is a microscopic parasite called Cyclospora cayetanensis that infects the intestines. People usually develop symptoms about a week after consuming contaminated food or water, although the incubation period can range from two days to two weeks or longer.

The most common symptom is prolonged watery diarrhoea, which may be accompanied by abdominal cramps, bloating, nausea, fatigue, loss of appetite, weight loss and increased gas.

Unlike many short-lived stomach infections, cyclosporiasis can persist or return if it is not treated. Prolonged diarrhoea can also lead to dehydration, which can become particularly dangerous in vulnerable people.

Also read: Broccoli Sprouts Linked To Salmonella Outbreak In US: 22 Cases Reported, FDA Says

Massive Scale Of The Outbreak

At its peak, more than 1,000 infections were reported in a single day before the recall. By August, infections had fallen to fewer than two per day on average, after which the CDC determined that the outbreak was over.

The FDA now says it is confident that all recalled iceberg lettuce linked with this specific outbreak has been removed from the market. The agency is continuing its investigation with US and Mexican authorities to determine the root cause and improve prevention measures.

Cyclospora Risk Still Persists

The specific lettuce outbreak is considered over, but Cyclospora infections have not disappeared from the US. CDC recorded 19,595 laboratory-confirmed, domestically acquired cyclosporiasis cases between May 1 and August 31, 2026.

The Taylor Farms outbreak accounted for more than half of those cases, while other Cyclospora clusters are still under investigation.

Consumers must understand that fresh produce can occasionally become contaminated with parasites before reaching the plate. FDA recommends following food-safety practices and carefully cleaning surfaces or containers that came into contact with recalled produce.

In an alarming report, Anthropic, an artificial intelligence safety and research company and developer of the Claude family of large language models, said it blocked multiple accounts that used its AI models in ways that could support the development of biological weapons.

In a report published Thursday, the San Francisco-based AI company described biological misuse as one of the “most serious risks” to increasingly capable AI models. The report covers attempts to misuse Claude between December 2025 and August 2026, including activity involving biology, weapons, cyberattacks, influence operations and surveillance.

It details five cases involving potentially concerning biological research, including chikungunya gain-of-function research, avian influenza, orthopoxviruses, venoms and toxins.

“We're publishing our most detailed threat intelligence report to date. It covers how people tried to misuse Claude—for cyberattacks, influence operations, surveillance, biology, and building weapons—and how we found and stopped them,” Anthropic said on X.

What Did Anthropic Find?

Anthropic identified about 35 potentially concerning “research efforts” over 30 days. It could not determine whether users “intended harm” or were conducting legitimate research.

Five cases involved users circumventing safeguards or regional restrictions:

• Chikungunya: AI was used in a gain-of-function project after safeguards were bypassed.
• Avian influenza: AI-assisted planning was used for experiments aimed at adapting the virus to mammals.
• Orthopoxvirus: AI was used to generate a grant application on viral immune evasion.
• Venoms: AI was used to optimise venom-related molecules.
• Toxins: AI was used to computationally redesign toxins.

Anthropic Says It Stopped The Operations

“We disrupted every operation in the report, and used the lessons from them to strengthen our safeguards,” Anthropic said.

The company said it also shared information with authorities and other AI companies where appropriate.

“These cases are not typical: we’re highlighting some of the most sophisticated misuse we’ve seen,” it said.

Can AI Enable Biological Misuse?

The report comes as former Anthropic employee Jacob Coxon resigned this week, stating on X that “the people building AI earnestly believe that it could kill us all by the end of the decade.”

The 27-year-old AI researcher said it could hack critical infrastructure — or build “extinction-level bioweapons.”

“There’s a lot of ways that the AI could actuate itself in the world,” he said. “If you extrapolate into the future, the level of capabilities of these AIs … they could cause extreme havoc,” Coxon later told CNN.

In July, nearly 1,400 AI company employees signed an open letter urging the US government to regulate the technology and slow its development to ensure its safety.

OpenAI Chief Scientist Jakub Pachocki also warned this week that AI capabilities are advancing faster than researchers’ ability to reliably monitor and control them.

Dr Ashish K. Jha, physician, scientist and biosecurity expert, said the Anthropic cases show how AI could lower some barriers to biological research.

“We are sleepwalking into a potentially huge disaster. And it amazes me how little attention it is getting,” Jha said on X.

“Anthropic just published five case studies today of people using Claude in ways that could have helped develop biological weapons. They banned the accounts, traced the networks, and told other AI labs and governments what they found.”

Jha said the barriers that once made biological weapons difficult to develop included “deep expertise, advanced equipment, years of specialized training.” “Those barriers are dissolving. Rapidly,” he said.

Jha also pointed to a case in which Claude blocked a request, after which the operator built a system to route it to a more permissive model.

“In a world of lots of open access models that are getting quite good, this will keep happening,” he said.