A new study has found that a combination of two drugs could enhance the immune system to treat one of the most common types of cancer in the world, bowel cancer. Also known as colorectal cancer, despite its widespread presence, the treatment options for this condition are limited. What the study specifically found was that this procedure could shrink the tumours caused by this condition by around 60%.

What Are The Drugs Involved

The trial involved the use of two immunotherapy drugs, botancilimab and balstilumab. It is a monoclonal antibody that works to stimulate the body's immune system to attack cancer. The study is a rather significant find, as it’s the first time that a consistent and durable response to immunotherapy has been reported in patients with solid MSS mCRC tumours.

The study was divided into several phases for more than 6 months. In the US trial, around around 101 patients with microsatile stable metastatic colorectal (MSS-mCRC) tumours showed a decrease . Around 61% of the patients experienced tumour shrinkage or stabilization after combined treatment with votancilumab and balstilumab. When it comes to downsides, diarrhea and fatigue were found to be the most common side effects or side effects of this drug.

These results are interesting and open to exploration. To date, immunotherapy has not been effective in patients with CNS-mCRC tumors. This study demonstrates the potential of the combination of botenlimab and balstilimab in the treatment of CNS mCRC, providing new hope for people diagnosed with colon cancer.

What Could This Mean For Bowel Cancer Treatment In The Future

The study is currently in the final stages of clinical trials, and the US Food and Drug Administration (FDA) hopes to quickly gain approval for its use because of the importance of this area that affects many people. The efficiency shown demonstrates the potential of botansilimab to contribute to broad antitumor immunity.

All in all, the combination of botensilimab and balstilimab represents a promising new direction in the treatment of colorectal cancer. This breakthrough could improve conditions for many patients worldwide and lights a new hope in the fight against this common disease. The results of this study show the effectiveness of immunotherapy in this field and how its potential to transform cancer treatment can only grow in the years to come.

The Keralam government has introduced the Keralam Senior Citizens (Care and Protection of Rights) Bill, 2026, to regulate elderly-care facilities and services. It proposes mandatory registration of care centers and caregivers, prescribed standards, caregiver certification, and penalties for violations.

Referred to the Assembly’s subject committee, the Bill would establish a legal framework for elderly care if passed.

Keralam introduced its first elderly-care policy in 2006, updated it in 2013, and released a draft State Policy for Elder Persons in August 2025. The state also enacted the Kerala State Senior Citizens Commission Act, 2025, and has a dedicated department for senior citizens’ welfare.

Why Does Keralam Need The Bill?

Also read: Healthy Lifestyle Changes Improve Memory, Thinking In Older Adults At Dementia Risk: The Lancet

Chief Minister V. D. Satheesan introduced the Bill, expressing confidence that it would make Kerala a model for elderly care.

“Nobody should feel that they are alone or abandoned. The way a society treats its elderly determines how civilized it is,” he said.

Keralam has one of India’s largest elderly populations, partly due to its high life expectancy. Older adults are projected to account for 22.8% of the state’s population over the next decade, up from 18.7%, highlighting the growing need for care services.

What Does The Bill Propose?

• Dignity and care: Promotes ageing in place, home-based care, safety, and social inclusion.
• Access and rights: Seeks better access to healthcare, legal aid, safe public spaces, digital inclusion, and abuse-reporting mechanisms.
• Protection units: Proposes state and district-level bodies to monitor care services and address complaints.
• Care-centre regulation: Requires registration of senior citizen care centres and sets service standards.
• Caregiver certification: Proposes training, phased certification, a Keralam Geriatric Care Certification Framework, and a state register of caregivers.
• Cybercrime safeguards: Proposes a Senior Citizen Cyber Fraud Cell at every cyber police station.
• Welfare funding: Calls for a state reserve fund for care, protection, welfare, and social security.
• Penalties: Provides for punishment for violations of the proposed law and related rules.

Why Elderly Care Needs A Broader Approach

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Speaking to HealthandMe, Dr. Rajeev Jayadevan, Ex-President of IMA Cochin and Convener of the Research Cell, Kerala, said the principles outlined in the Bill could eventually apply across India, particularly as Keralam has a higher proportion of older adults than many other states.

With shrinking nuclear families and urbanization, fewer family members may be available to provide full-time care, increasing reliance on state-supported services, including home care, medical consultations, and palliative care.

He emphasized that older adults have distinct care needs and highlighted patient autonomy in end-of-life decisions. Living wills allow people to document their medical-care preferences in advance, helping families and healthcare professionals understand their wishes and potentially avoid unwanted interventions.

Dr. Rajeev also stressed the need for trained, certified caregivers, effective oversight of care providers, and safeguards against elder abuse.

As older adults increasingly use digital platforms for services such as banking, digital literacy and protection against online scams and financial fraud are also essential, he noted.

What Are The Health Challenges Facing Older Adults?

READ: Normal Ageing or Alzheimer's? Doctors Explain Six Key Differences to Watch For

India’s senior citizen population is projected to reach around 230 million by 2036, or approximately 15% of the population. Southern states, along with Himachal Pradesh and Punjab, have larger elderly populations, with regional disparities expected to widen.

Moody’s Ratings said in September that India’s population is expected to age significantly as fertility falls below replacement levels.

Older adults often face chronic conditions such as diabetes, high blood pressure, and high cholesterol, alongside complications including diabetic kidney disease, diabetic retinopathy, cataracts, and glaucoma. These health needs underscore the importance of accessible, coordinated long-term care.

CVS Pharmacy and its subsidiaries have agreed to pay $315 million to settle a US Department of Justice lawsuit alleging that the pharmacy chain unlawfully dispensed opioid prescriptions that were not needed medically.

The settlement, announced on October 13, also requires the company to implement safeguards against inappropriate and unnecessary dispensing.

Filed in December 2024, the lawsuit alleged that CVS dispensed prescriptions that lacked a legitimate medical purpose, involved excessive quantities of opioids or were dispensed too early.

The government also alleged that the company filled prescriptions from so-called “pill mills”, suppliers who are accused of issuing large numbers of controlled-substance prescriptions without a legitimate medical purpose. CVS has strongly disputed the allegations and denies any wrongdoing as part of the settlement. The agreement resolves the civil claims without a determination of liability.

Unsafe Opioid Prescriptions Can Increase Addiction Risk

Also read: Why Is The US Fast Tracking Trials Of Ibogaine, A Schedule I Controlled Substance, Despite Safety Risks

Opioids are powerful medications used to treat moderate to severe pain. They include prescription drugs like oxycodone, hydrocodone and morphine.

When prescribed appropriately and taken under medical supervision, they can provide important relief. However, their effects on the brain'can also lead to dependence and addiction issues.

Dependence and addiction are related but different. Physical dependence occurs when the body adapts to a medication. If stopped abruptly, one may experience severe withdrawal symptoms.

Opioid use disorder, commonly referred to as opioid addiction, involves a destructive pattern that can include cravings, loss of control and continued use despite harmful consequences.

The risk increases when these opioids are prescribed or taken in excessive doses or combined with other similar medicines. Taking more than prescribed can also increase the risk of overdose, which can slow or stop breathing and may be fatal.

The Justice Department's lawsuit alleged that CVS dispensed prescriptions for dangerous combinations of medicines, including “trinity” prescriptions combining an opioid, a benzodiazepine and a muscle relaxant. Such combinations can lead to a compounded sedation effect and respiratory depression, increasing the risk of serious harm.

In these cases, addiction becomes more than just a habit. These substances alter brain chemistry, particularly in the areas related to reward, motivation, and self-control. Hence, recovery is not simply about choosing to quit.

Addiction hijacks the brain’s prefrontal cortex—the area responsible for decision-making, self-control, and judgment. As a result, people suffering from addiction are often unable to regulate their behavior, even when they want to.

The brain’s reward system reinforces substance use by releasing dopamine, the chemical associated with pleasure and reward. Over time, the brain becomes dependent on this chemical surge, leading to tolerance (needing more of the substance to feel the same effect) and withdrawal symptoms when the substance is not available.

Also read: ‘Zombie’ Drug Medetomidine, Spotted In Heroin Supply, Raises Concern As It Could Evade Overdose Antidote

What Did The Lawsuit Allege?

According to the Justice Department, the alleged dispensing practices occurred between October 2013 and December 2025. The government claimed that staffing shortages, performance targets and incentive policies contributed to pharmacists filling prescriptions without adequately checking whether they were legitimate.

Many of the prescriptions were allegedly billed to federal healthcare programmes, including Medicare and Medicaid, prompting claims under the federal False Claims Act as well as the Controlled Substances Act.

“Today's settlement is a significant milestone in the Justice Department's efforts to combat the opioid epidemic by cracking down on pharmacies who unlawfully fulfill prescriptions for controlled substances,” Associate Attorney General Stanley Woodward said in a statement.

CVS said its pharmacists were trained “in the safe and appropriate use of all medications” and that the company had introduced programmes to help them make appropriate decisions for patients.

Days after announcing that Pope Leo XIV will have surgery to have a lung nodule removed, he got a confirmed diagnosis of lung cancer. According to reports, he underwent surgery to have the lower lobe of his right lung removed.

The update comes as the 71-year-old pontiff's older brother, Louis Prevost, is undergoing treatment for relapsed multiple myeloma. The developments have brought attention to two different cancers affecting the papal family.

Pope Leo XIV's Lung Cancer Diagnosis

The pope underwent the procedure at Rome's Gemelli Hospital on October 13. According to the Vatican, tests confirmed lung adenocarcinoma, a type of cancer that develops in the cells lining the lungs.

The Vatican said in a medical bulletin, "The surgery was successful, and there were no complications."

The operation lasted approximately 90 minutes, and the pope subsequently returned to his hospital room. Pope Leo had announced on October 11 that doctors had discovered a lung nodule during routine medical examinations. He said the abnormality was detected early and that doctors recommended surgery to remove it.

"Dear friends, during some recent medical examinations, the doctors found a small, localized nodule in my lung. It was detected at a very early stage and is well-localized," he said.

He added, “The doctors believe it is advisable to intervene, so, following their advice, I have decided to undergo surgery to remove it. The operation is already scheduled for the next few days.”

The Vatican has not yet disclosed Pope Leo's cancer's stage or whether it has metastatised to other parts of the body. Further testing, including examination of the lymph nodes, will help doctors determine the extent of the disease and whether additional treatment is necessary.

Also read: Pope Leo XIV Will Undergo Lung Nodule Surgery: When Does Removal Become Necessary

What Is Lung Adenocarcinoma?

Lung adenocarcinoma is the most common type of lung cancer. It develops in glandular cells that produce substances like mucus. It is classified as a non-small cell lung cancer.

Although it is frequently linked with smoking, it can also occur in people who have never smoked. Other risk factors include exposure to radon, second-hand smoke and certain workplace carcinogens.

Symptoms may include a persistent cough, coughing up blood, chest pain, breathlessness and unexplained weight loss. Early-stage disease may cause no noticeable symptoms but it can be detected through imaging and scans.

Treatment largely depends on the cancer's stage, location and characteristics of the tumour. Surgery to remove the affected portion of the lung is a common treatment strategy when the tumour is localised. Chemotherapy, immunotherapy or targeted therapies may be considered depending on further findings.

In Pope Leo's case, the lower lobe of his right lung was removed. The results of further tests will help establish whether surgery alone is sufficient.

Also read: How Does Second-hand Smoke Exposure Increase The Risk Of Lung Cancer In People Who Have Never Smoked Themselves?

Pope's Brother Louis Prevost's Multiple Myeloma Relapsed

Meanwhile, the pope's older brother, Louis Prevost, is receiving treatment for multiple myeloma, a blood cancer that affects plasma cells in the bone marrow. His wife, Deborah Prevost, told CBS News that he was first diagnosed in 2017.

Treatment in 2019, which included stem cell treatment and participation in a clinical trial, helped keep the disease at a "very low level".

However, she said he "fell out of remission" approximately three months ago. He is now participating in another clinical trial at a local hospital in Florida.

Multiple myeloma develops when abnormal plasma cells multiply in the bone marrow, interfering with normal blood cell production and damaging bones and kidneys.

Symptoms can include bone pain, fatigue, frequent infections, anaemia and kidney problems.

Unlike lung adenocarcinoma, which forms a solid tumour in lung tissue, multiple myeloma is a cancer of plasma cells. It is generally considered treatable but not usually curable, and the disease can return after periods of remission.

Speaking about the family's situation, Deborah said, "We keep praying, keeping spirits up for both of them."