A new study has found that a combination of two drugs could enhance the immune system to treat one of the most common types of cancer in the world, bowel cancer. Also known as colorectal cancer, despite its widespread presence, the treatment options for this condition are limited. What the study specifically found was that this procedure could shrink the tumours caused by this condition by around 60%.

What Are The Drugs Involved

The trial involved the use of two immunotherapy drugs, botancilimab and balstilumab. It is a monoclonal antibody that works to stimulate the body's immune system to attack cancer. The study is a rather significant find, as it’s the first time that a consistent and durable response to immunotherapy has been reported in patients with solid MSS mCRC tumours.

The study was divided into several phases for more than 6 months. In the US trial, around around 101 patients with microsatile stable metastatic colorectal (MSS-mCRC) tumours showed a decrease . Around 61% of the patients experienced tumour shrinkage or stabilization after combined treatment with votancilumab and balstilumab. When it comes to downsides, diarrhea and fatigue were found to be the most common side effects or side effects of this drug.

These results are interesting and open to exploration. To date, immunotherapy has not been effective in patients with CNS-mCRC tumors. This study demonstrates the potential of the combination of botenlimab and balstilimab in the treatment of CNS mCRC, providing new hope for people diagnosed with colon cancer.

What Could This Mean For Bowel Cancer Treatment In The Future

The study is currently in the final stages of clinical trials, and the US Food and Drug Administration (FDA) hopes to quickly gain approval for its use because of the importance of this area that affects many people. The efficiency shown demonstrates the potential of botansilimab to contribute to broad antitumor immunity.

All in all, the combination of botensilimab and balstilimab represents a promising new direction in the treatment of colorectal cancer. This breakthrough could improve conditions for many patients worldwide and lights a new hope in the fight against this common disease. The results of this study show the effectiveness of immunotherapy in this field and how its potential to transform cancer treatment can only grow in the years to come.

A plant-based diet is highly recommended for a healthy heart — weight watchers can also benefit from it, as can diabetics. When one goes vegan, the biggest change comes when one moves from dairy milk to oat, almond, or soy milk. Parents, too, are now shifting their children to trendy vegan milk options — little do they realise that this could bring their worst fears to life. According to the British Society for Allergy & Clinical Immunology, drinks that are aimed at children and often marketed as healthy are usually loaded with sugar and offer little or no nutrition.

Why has plant milk become a preferred choice?

Experts found that children under five years of age are more prone to malnutrition, tooth decay, or even obesity. The study is the first of its kind, and its warning will be published in the coming week. It is backed by the British Dental Association and the British Dietetic Association. Doctors say that plant-based drinks are often compared to cow’s milk in terms of nutrition. However, these claims are not supported by current evidence.

Why is plant milk discouraged for children?

Plant milk has gained popularity in recent years because of the health benefits that many believe it offers. While adults may benefit from it in several ways, toddlers must not be given these packaged, sugary drinks. The added sugars can become nothing more than a frequent treat for children, who may lose their milk teeth sooner and suffer from decay. Researchers found that families are often convinced that plant milk is good for children, but these oat, almond, and soy versions of milk are processed and full of sucrose and fructose syrups.

According to a report, most of these drinks contain large amounts of sugar in the form of maltodextrin, glucose syrup, sucrose, and fructose. A 350 ml glass of such milk contains more than double a toddler’s daily sugar allowance. Ideally, toddlers should not be given more than 14 grams of sugar every day. Their young bodies can struggle to absorb vitamin B12 and calcium from plant drinks. The BSACI recommends that parents opt for unsweetened, fortified plant milk instead, as these can play a crucial role in supporting children’s health.

How do ultra-processed foods affect children’s health?

Ultra-processed foods (UPFs) are defined as food groups that undergo a great deal of processing — the most natural foods fall under Group 1, while heavily processed foods are placed under Group 4. While these do not definitively determine how healthy a food option is, they indicate the level of processing involved. Highly processed foods are associated with a range of health problems, which is why it is important to make informed dietary choices.

What are minimally processed foods?

In your kitchen, foods with a minimal level of processing include:

1. Fruits
2. Vegetables
3. Grains
4. Legumes
5. Meat and poultry
6. Eggs
7. Fish and seafood
8. Fresh milk
9. Spices and herbs
10. Coffee and tea
11. Nuts and seeds
12. Plain yoghurt

What are ultra-processed foods in your kitchen?

Some of the most processed foods in your kitchen include:

1. Sweetened yoghurt
2. Soft drinks
3. Biscuits
4. Breakfast cereals
5. Candies
6. Cake mixes
7. Breads and buns
8. Energy drinks
9. Energy bars
10. Frozen foods — pies, pizzas, snacks, sausages, pepperoni, ham, and salami
11. Instant foods — noodles, soups, and sauces

Desk jobs cause just as much damage as smoking. Several studies have stated that sitting for prolonged hours does the same amount of damage as smoking, and for that reason, experts have recommended exercise. Doctors and scientists have long said that working out is a good way to combat the damage caused by prolonged sitting hours—but a new study begs to differ. It turns out that the damage caused by sitting too much can contribute to the risk of heart disease, early death, and even type 2 diabetes. However, working out and eating right may not be sufficient to make up for this loss.

What are the physical effects of long sitting hours?

Physical inactivity refers to not engaging in vigorous or moderate workouts. Public health guidelines suggest 150 minutes of moderate-intensity workouts like cycling or brisk walking and 75 minutes of vigorous workouts like running. Sedentary behaviour, on the other hand, refers to reclining with low energy expenditure or long durations of sitting in front of a desk or television or during a long commute.

Experts say that a person can, therefore, be physically active yet live a sedentary lifestyle. Some can also go for a run before work and yet remain seated for about the next eight hours. This workout helps, but it does not combat the ill effects of sitting for long hours. When the body stays still for longer periods, a series of changes occur — skeletal muscle activity levels drop, making it difficult for the body to absorb glucose from the blood. This can result in insulin resistance and eventually type 2 diabetes.

What happens when you sit for long hours?

Blood circulation also becomes inefficient, and nutrients and oxygen take much longer to reach the tissues, thereby impairing vascular function and raising blood pressure. Together, these circulatory changes can lead to high cholesterol, belly fat accumulation, and high blood sugar. Prolonged sitting also impacts the musculoskeletal system. Limited movement and poor posture have an adverse impact on the lower back, neck, and shoulders, explaining why pains and aches are common among corporate workers.

How do long sitting hours affect mental health?

The effects of long sitting hours can impact your brain as well, reducing energy levels, alertness, and concentration. Employees who sit for extended durations are less productive and feel more sluggish at work. Globally, this leads to four to five million deaths every year, hence explaining why regular workouts are encouraged.

Can regular exercise combat the ill effects of long sitting hours?

It turns out that taking a gym membership and going for regular workouts may not be sufficient to combat the ill effects of long sitting hours. On the other hand, small and regular interruptions can make a difference. Research suggests that moving or standing up for even two to five minutes every 30 to 60 minutes can improve glucose metabolism and reduce heart-related risks too.

According to a study of offices in the UK, these measures can reduce daily sitting time by one to one and a half hours. Employees involved reported better musculoskeletal comfort, energy, and focus. This makes the message evident—regular workouts are essential, but they may not fully combat the risks associated with long sitting hours. A quick walk after lunch, attending to phone calls while taking a short walk, or even taking small breaks every now and then—these small efforts will help you protect your health better than most other remedies. For a modern corporate employee, protecting health need not be about exercising after work but about sitting less and moving more even while work is ongoing.

If you thought that the worst in terms of the heatwave was coming to an end, you were wrong. While heatwaves are an unfortunate common occurrence in India, this year is different. Earlier, in 2025, the summer brought India to its knees, with temperatures soaring as high as 50 degrees Celsius in parts of the country. And this year, temperatures have already crossed the 47 degrees Celsius mark—and reports suggest that the worst is yet to come. This year, experts are expecting the possibility of a “Super El Niño." Ever heard about it? Let’s find out what it means.

What is Super El Niño?

Super El Niño is a climate phenomenon occurring once every two to seven years. It occurs when ocean surface temperatures rise in the eastern and central Pacific. As a result, a strong event occurs, known as “Super El Niño”, which can intensify global heat.

Has India entered the El Niño phase?

The India Meteorological Department (IMD) has issued advisories for people living in heatwave-struck parts of the country. Recently, a report from AQI.in found that, out of the 100 hottest cities in the world, India is home to 95. This, in a way, makes India the hottest country in the world. Several heatstroke-related deaths have been reported in the country in the month of April itself —andthe heatwave is likely to worsen in May and June. Cities in Uttar Pradesh and Chhattisgarh are at the top of the list, as the top 10 hottest ones are in these states. Temperatures have consistently been over 40 degrees in these cities. Odisha, Karnataka, and Kerala are also in the grip of this severe heatwave.

While it cannot be conclusively said that India is in its El Niño phase, the current scenario mimics the effects already. The IMD is therefore urging people, through its advisories, to stay safe and hydrated. Extended hot days can lead to various impacts, including an increased risk of health issues like heatstroke, higher electricity consumption, and water shortages,” the advisory suggests. Experts say that India is particularly vulnerable to this heat stress due to its monsoon and high pre-monsoon temperatures. However, human-related factors worsen this situation, such as urban development and diminishing green cover.

Some experts, however, are saying that the ongoing heatwave is not an El Niño; rather, it is an anti-cyclonic pressure over northern and central India, which is working like a heat dome. However, the possibility of a stronger El Niño cannot be completely ruled out. Previously, it occurred in 1997–1998 and 2015–2016, resulting in drought-like conditions.

Can the heatwave trigger heart attacks?

In an interview with Health and Me, Dr Joy Shome, Head of TAVI/TAVR at CK Birla Hospitals, BM Birla Heart Hospitals, said, "An alarming rise in the number of young adults who experience cardiac events has been observed due to heatwaves that are becoming more common and more extreme (as outlined in the Beat by Beat report). The cardiovascular system is put under enormous strain by excessive amounts of heat. To help cool down the body, our blood vessels expand (dilate), and the heart must pump more blood through them; however, dehydration results in thicker blood, increasing your chance of developing a blood clot (a leading cause of heart attacks)."

Dr Shome also said that heart disease is no longer only affecting the elderly; a substantial number of cardiac deaths occur prematurely and affect younger populations. Lifestyle, stress, and metabolic issues are all contributors to this trend. India has contributed nearly one in five cardiac deaths worldwide, and cardiovascular disease accounts for around 25% of all deaths in India—illustrating how large this crisis is. The ‘thin fat’ phenomenon is another factor; many Indian people may look thin but have significant amounts of visceral fat — meaning many young adults could be at risk of suffering a heart attack.

Is the heatwave making people in India fall sick?

States and Union Territories have been instructed by the Ministry of Health and Family Welfare to create heatwave management units, issue early warnings, and maintain real-time reporting of heatstroke cases. These measures, however, may not be enough, especially for vulnerable groups of people. Severe heatwaves can lead to death, yes; however, there is a risk of heat stress, heatstroke, and even dehydration.

In an interview with Health and Me, Dr Manjusha Agarwal, Consultant - Internal Medicine, Gleneagles Hospital Mumbai, spoke about the possible effects of a Super El Niño on health. The expert spoke about whether or not it is this heatwave that is making people in India fall sick.

A potential Super El Niño is known to intensify heatstroke and can place a significant stress on the heart. So, the impact can be directly seen on the cardiovascular system during the scorching heat. Not only this, many people may also experience dehydration and heatstroke or even respiratory illnesses and vector-borne diseases like dengue and malaria. So, everyone needs to be cautious and prioritise heart health. When temperatures rise, the body tries to cool itself by increasing blood flow to the skin, which tends to stress the heart.

Dr Agarwal went on to say that constant sweating during summer leads to fluid and electrolyte loss, making the blood thicker, and there can be chances of clotting. This can raise the chances of heart attacks or strokes, mainly in those with a history of pre-existing conditions such as hypertension, diabetes, or heart disease. They may experience concerning symptoms like dizziness, fatigue, or palpitations, which are neglected by many people.

So, when there is scorching heat outside, it is necessary for everyone to stay hydrated by drinking 2-3 litres of water, maintain electrolyte balance, avoid peak heat hours that are from 12:00 pm to 5:00 pm, and take medication prescribed by the doctor. Everyone should be aware when it comes to heart health and overall well-being. Hence, it is time to follow these vital types and protect the heart during intense heat.