A new study has found that a combination of two drugs could enhance the immune system to treat one of the most common types of cancer in the world, bowel cancer. Also known as colorectal cancer, despite its widespread presence, the treatment options for this condition are limited. What the study specifically found was that this procedure could shrink the tumours caused by this condition by around 60%.

What Are The Drugs Involved

The trial involved the use of two immunotherapy drugs, botancilimab and balstilumab. It is a monoclonal antibody that works to stimulate the body's immune system to attack cancer. The study is a rather significant find, as it’s the first time that a consistent and durable response to immunotherapy has been reported in patients with solid MSS mCRC tumours.

The study was divided into several phases for more than 6 months. In the US trial, around around 101 patients with microsatile stable metastatic colorectal (MSS-mCRC) tumours showed a decrease . Around 61% of the patients experienced tumour shrinkage or stabilization after combined treatment with votancilumab and balstilumab. When it comes to downsides, diarrhea and fatigue were found to be the most common side effects or side effects of this drug.

These results are interesting and open to exploration. To date, immunotherapy has not been effective in patients with CNS-mCRC tumors. This study demonstrates the potential of the combination of botenlimab and balstilimab in the treatment of CNS mCRC, providing new hope for people diagnosed with colon cancer.

What Could This Mean For Bowel Cancer Treatment In The Future

The study is currently in the final stages of clinical trials, and the US Food and Drug Administration (FDA) hopes to quickly gain approval for its use because of the importance of this area that affects many people. The efficiency shown demonstrates the potential of botansilimab to contribute to broad antitumor immunity.

All in all, the combination of botensilimab and balstilimab represents a promising new direction in the treatment of colorectal cancer. This breakthrough could improve conditions for many patients worldwide and lights a new hope in the fight against this common disease. The results of this study show the effectiveness of immunotherapy in this field and how its potential to transform cancer treatment can only grow in the years to come.

Mojtaba Khamenei, the newly appointed supreme leader of Iran, has been ‘incapacitated’, according to a media report.

The UK-based The Times reported that Mojtaba Khamenei is critically ill and is unable to govern and has thus been placed under medical care in the religious city of Qom.

The report cited a diplomatic memo, based on US and Israeli intelligence, which indicates that Mojtaba Khamenei is unconscious and in a “severe” condition.

Meanwhile, Iranian authorities have acknowledged that Khamenei was wounded in the same airstrike that killed his father, former supreme leader Ali Khamenei, along with close family members on the opening day of the war. Since then, he has not appeared publicly.

Earlier, US President Donald Trump also reiterated claims that Mojtaba Khamenei could be dead or seriously injured, saying there has been no public confirmation of his condition, Financial Times reported.

What Does The Term ‘Incapacitated’ Mean Medically?

The Journal of Family Practice explains that being incapacitated “is the clinical state in which a patient is unable to participate in a meaningful way”. The condition can be both physical or mental.

It includes:

• Loss of physical mobility: unable to move, walk, or perform basic tasks
• Cognitive Decline
• Severe illness or injury
• Coma,
• Advanced dementia,
• Severe mental illness,
• Delirium.

Who Is Mojtaba Khamenei

The 56-year-old Mojtaba Khamenei is the son of former supreme leader Ayatollah Ali Khamenei, who was killed in a US-Israeli strike on February 28 -- the first day of the ongoing war.

He was elevated to the position of his father on March 8 after Iran’s Assembly of Experts—the clerical body responsible for appointing the supreme leader—formally selected him as successor amid wartime conditions.

Since his appointment, Mojtaba has not appeared at any funeral for senior commanders killed in the strikes, issued no video messages, and released no photographs.

However, Israeli media i24NEWS quoted sources who said Mojtaba Khamenei does not control Iran and "most likely, the Revolutionary Guards control the state”.

A viral video of the new Supreme Leader shows him walking into a war room and analyzing a map of Israel’s nuclear power plant in Dimona has been debunked as AI-generated.

Is Incapacitation A Serious Health Condition?

An individual who is incapacitated requires urgent care, as the person is at significant risk of

• organ failure,
• brain damage,
• infections,
• long-term disability even after recovery.

Former US President Woodrow Wilson

The vaccine-preventable measles, a deadly infectious disease, has claimed the lives of 98 children in Bangladesh, in the country’s one of the worst outbreaks, media reports said.

According to the latest data from the country’s Ministry of Health, the number of children aged six months to five years old with suspected measles symptoms has soared to 6,476, AFP News Agency reported

“Compared with past years, the number of affected children is higher, and the death toll is higher too,” Halimur Rashid, director at Communicable Disease Control, was quoted as saying.

The largest number of suspected cases on record was in 2005 at 25,934, according to World Health Organization (WHO) data. That number had significantly declined in succeeding years until this year.

Measles Outbreak: Emergency Vaccination Drive

Official data show that in 2026, more than 2,300 children were admitted to the hospital with suspected measles.

The outbreak has also prompted the government to roll out a vaccination program for younger children in a bid to halt the outbreak. The emergency vaccination drive will be launched in 18 high-risk districts, and will also be expanded from May 3 to cover the entire country.

Directorate General of Health Services (DGHS) said 10 of the total 94 measles-related deaths occurred in 24 hours ending at 8 am Sunday, even as the number of suspected measles cases detected grew to 5,792 during the 19 days, 974 of them since Saturday.

"The highly infectious disease has seen a sharp rise this year, particularly since March," a DGHS statement said, attributing the phenomenon to the vaccination gap last year, PTI reported.

The officials noted that the disease is spreading rapidly and has affected 56 out of 64 administrative districts.

Health Minister Sardar Shakhawat Hossain Bakul said the emergency vaccination drive would cover the "worst affected areas" before being expanded throughout Bangladesh.

What Is Measles?

Measles is a highly contagious virus that spreads through direct contact or through the air when an infected person coughs or sneezes.

Symptoms typically appear seven to 14 days after exposure and may include:

• high fever,
• cough,
• runny nose,
• red eyes,
• rashes across the body.

Measles And Vaccination

The reports of deaths from Bangladesh indicate the presence of a significant 'immunity gap,” allowing the virus to take hold.

How Does Measles Spread

Measles is a highly contagious viral disease that spreads rapidly through respiratory droplets when an infected person coughs or sneezes.

Crowded living conditions, poor ventilation, and low immunity levels increase the risk of transmission.

In addition to incomplete or missed vaccination, lack of awareness, and malnutrition (especially vitamin A deficiency) contribute to outbreaks.

How To Stay Safe

To safeguard against measles, individuals should:

• Ensure timely vaccination, especially for children.
• Maintaining good hygiene, such as frequent handwashing and covering the mouth while coughing or sneezing
• Avoiding close contact with infected individuals
• Eensure proper nutrition to boost immunity
• Public awareness and community health programs also play a crucial role.

A young Internal Medicine doctor from Chandigarh has highlighted shocking malpractices followed by a well-known private hospital.

In a widely shared video posted on social media platform Instagram, Dr Prabhleen Kaur alleged that all patients arriving at the hospital in the city are being forcibly kept in Intensive Care Units (ICUs) even when it is not required.

The doctor had joined the hospital, as it was paying well and was near her clinic. However, seeing the blatant scam, she resigned in just one day.

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“I joined a very reputed hospital. I thought I would work there in the mornings and run OPD at my own clinic in the evenings. They were paying really well, no doubt about that,” the doctor said in the video.

The doctor alleged that the hospital “just needed a physician for the show”, while the entire handling of patients was being done by the owner, a gynecologist.

“But on my very first day, I realised that they only needed a physician in name. The hospital owner, who was a gynaecologist and not a physician, was managing all the patients herself. That means she would decide every patient should be admitted, and she would also decide that every admitted patient should be kept in the ICU – and kept there for as many days as possible,” Kaur said.

She further claimed that the goal at the said hospital was to make the patients remain admitted in the ICU for as long as possible. Kaur added she was deeply disturbed seeing this and refused to be part of a system that “harms patients for money.”

“It would have been my name, but their wrongdoing. So I resigned, because I cannot allow someone to use me as a front for unethical practices,” she said.

The doctor did not mention the name of the hospital. And HealthandMe could not independently verify the details and the authenticity of the post.

However, the incident reignites concerns over accountability, patient safety, and standards of care in the country.

The video went viral and the netizens found it concerning, and some also pointed out that such issues are common with many hospitals across the country.

"Unfortunately, most doctors are doing this unethical practice these days,” a user said.

“No surprise— the moment you enter a hospital, the first question is about insurance coverage. Feels like treatment comes second and billing comes first,” added another.

Some also lauded the doctor for resigning and sounding the alarm.

“Salute to your integrity. Rest of the Indians are just after making money,” said a user, while another noted: “Respect to this doctor for choosing her conscience over money".

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Other Such Incidents

This is not the first such incident of hospital malpractice in the country.

Days earlier, a doctor from Assam called out private hospitals for overcharging patients with inflated medicine prices and unnecessary lab tests.

Dr Priyam Bordoloi said that corporate hospital chains rely on “predatory” practices and become a “financial sinkhole” for patients.

Earlier in January this year, a viral video with allegations of gross medical negligence and institutional apathy at Dhubri Medical College and Hospital (DMCH) sparked public outrage.

The video showed a family accusing hospital staff of failing to provide basic care, delaying critical dialysis treatment, and obstructing an emergency transfer.

The incident involved a 74-year-old Fulchand Chowdhury, whose condition reportedly worsened due to lapses in ICU monitoring, sanitation, and patient safety.

The family claimed they were forced to care for him themselves and faced resistance when seeking transfer to a private facility.

Also read: Bob Harris: BBC Radio 2 Host Hospitalized For Prostate Cancer Treatment

Who Should Be Kept In The ICU?

In January 2024, India launched guidelines for hospitals on ICU admissions and directed that hospitals cannot admit critically ill patients to the ICU without the consent of the patient and family.

According to the latest guidelines, patients who are critically ill should not be admitted to an ICU if they do not give their consent.

"Critically ill patients should not be admitted to the ICU; if the patient or next-of-kin informed refusal to be admitted in ICU."