A new study has found that a combination of two drugs could enhance the immune system to treat one of the most common types of cancer in the world, bowel cancer. Also known as colorectal cancer, despite its widespread presence, the treatment options for this condition are limited. What the study specifically found was that this procedure could shrink the tumours caused by this condition by around 60%.

What Are The Drugs Involved

The trial involved the use of two immunotherapy drugs, botancilimab and balstilumab. It is a monoclonal antibody that works to stimulate the body's immune system to attack cancer. The study is a rather significant find, as it’s the first time that a consistent and durable response to immunotherapy has been reported in patients with solid MSS mCRC tumours.

The study was divided into several phases for more than 6 months. In the US trial, around around 101 patients with microsatile stable metastatic colorectal (MSS-mCRC) tumours showed a decrease . Around 61% of the patients experienced tumour shrinkage or stabilization after combined treatment with votancilumab and balstilumab. When it comes to downsides, diarrhea and fatigue were found to be the most common side effects or side effects of this drug.

These results are interesting and open to exploration. To date, immunotherapy has not been effective in patients with CNS-mCRC tumors. This study demonstrates the potential of the combination of botenlimab and balstilimab in the treatment of CNS mCRC, providing new hope for people diagnosed with colon cancer.

What Could This Mean For Bowel Cancer Treatment In The Future

The study is currently in the final stages of clinical trials, and the US Food and Drug Administration (FDA) hopes to quickly gain approval for its use because of the importance of this area that affects many people. The efficiency shown demonstrates the potential of botansilimab to contribute to broad antitumor immunity.

All in all, the combination of botensilimab and balstilimab represents a promising new direction in the treatment of colorectal cancer. This breakthrough could improve conditions for many patients worldwide and lights a new hope in the fight against this common disease. The results of this study show the effectiveness of immunotherapy in this field and how its potential to transform cancer treatment can only grow in the years to come.

The United States Secretary of Health and Human Services Robert F. Kennedy Jr. recently announcing new measures to expand investigation into health problems and other side effects reported after vaccination.

The initiative includes a new National Institutes of Health (NIH) clinic, payments to doctors for reporting suspected injuries related to vaccines, and changes to the systems used to collect safety data.

Announced on October 8, 2026, the initiative aims to understand possible complications related to vaccines. However, it has also raised questions about whether increased reporting could distort public concern about vaccine safety without sufficient evidence of causation.

“We must listen to patients and families who report vaccine injuries—not dismiss or gaslight them,” Kennedy said in a statement from the Department of Health and Human Services (HHS). “President Trump and I are building a health system that takes them seriously, follows the evidence, and uses what we learn to make vaccines safer. This is how we earn back trust in our public health institutions.”

What Changes Were Proposed By US Health Secretary?

The HHS initiative includes four major measures:

• A new NIH clinic: Opened on October 5, the clinic will study and provide care for people experiencing health problems after vaccination.
• Payments for reporting: The Centers for Medicare and Medicaid Services has proposed reimbursing doctors for reporting suspected vaccine-related injuries to the Vaccine Adverse Event Reporting System (VAERS).
• Electronic health records: The government intends to access electronic health records to track adverse events after vaccination.
• Modernising VAERS: The system will be updated to simplify reporting and improve the tools available to researchers and healthcare professionals. VAERS, jointly managed by the US Centers for Disease Control and Prevention (CDC) and the Food and Drug Administration (FDA), already accepts reports from patients, family members, healthcare providers and vaccine manufacturers.

Also read: Nearly 4,000 Measles Cases In US: CDC Director Says MMR Vaccine Is ‘Absolutely Safe’

What Are The Benefits Of Vaccine-Injury Reporting?

Vaccines can occasionally cause adverse side effects. Most reported side effects are mild, but in rare cases, serious events may occur. Identifying these reactions is key for improving vaccine safety.

Expanding reporting could help researchers detect unusual risk factors and identify adverse events. Trials involving relatively small numbers of participants may not always detect very rare complications that can emerge only after a vaccine is administered to millions of people.

More complete electronic health records could also help clinicians identify patterns across different settings, while a dedicated NIH clinic could provide care to patients whose symptoms require further investigation.

Also read: Plague Treatable, CDC Monitoring US Arrivals From Russia After Worker’s Death, Says Director Erica Schwartz

What Are The Risks?

More reports do not automatically mean more vaccine injuries. VAERS accepts reports of health problems occurring after vaccination, even when the person reporting them is unsure whether the vaccine caused the problem.

The CDC explicitly states that a VAERS report does not establish causation. Reports may be incomplete, contain errors or describe illnesses unrelated to vaccination. Establishing a causal link requires further investigation, including clinical assessment and analysis of other possible explanations.

The CDC also warns that media attention and increased public awareness can lead to more reports, complicating efforts to identify genuine safety signals. If raw reporting numbers are presented as proof that vaccines are dangerous, they can create misleading impressions and contribute to mistrust in vaccine.

The proposal to reimburse doctors for reporting suspected injuries also raises questions about how these incentives will be designed, monitored and interpreted. More reports may improve surveillance, but the value of the system will depend on the quality of the information.

Since July 2025, at least 52 maternity units across the United States have been shut down. Eight more closures were announced recently, raising concerns that upcoming federal Medicaid cuts could further restrict access to pregnancy and neonatal care, especially in rural communities and regions with limited healthcare resources.

The closures come as hospitals prepare for changes under the HR1 bill, which will reduce federal Medicaid funding and introduce stricter eligibility rules and work requirements. Although the legislation's impact is expected to be felt in 2027, some hospitals have already cited the anticipated changes as a reason for ending maternity services.

US Maternity Units Are Closing

Also read: High BP in Pregnancy Linked to 42,000 Maternal Deaths, 500,000+ Stillbirths, Newborn Deaths: WHO

Maternity wards are expensive to operate because they require round-the-clock staff, special equipment and teams trained for emergencies. Low reimbursement rates, staffing shortages, and declining birth rates have already placed financial pressure on hospitals. Reduced Medicaid funding could make it harder for some hospitals to keep these services.

Erin Jones, senior director of legislative and strategic counsel at the nonprofit March of Dimes, warned that the changes could worsen existing healthcare problems.

“We’re deeply concerned that these changes already have and will continue to worsen an already serious maternity care crisis,” she said. “Reduced funding and restrictions on how states finance Medicaid will put additional pressure on state budgets and hospitals, increasing the risk that communities lose essential maternity services and specialized providers close to home.”

Hospitals that have permanently closed maternity wards include Centra Southside Community Hospital in Virginia and St Mary’s Sacred Heart Hospital in rural northeastern Georgia. Both mentioned upcoming federal Medicaid policy changes as the reasons for their decisions.

Impact Of Medicaid Cuts On Pregnant Women

Also read: American Academy of Pediatrics Warns Of Raw Milk Risks, Calls For Ban

Medicaid is a major source of health coverage for low-income Americans, paying for approximately 40% of births in the country. Changes to the program could affect hospitals’ finances as well as patients’ ability to receive health coverage.

Although pregnant women are supposed to be exempt from the new work requirements, eligibility rules could still create difficulties for some patients.

Benjamin Sommers, a professor of healthcare economics at Harvard University’s T.H. Chan School of Public Health, said the law would “absolutely” affect pregnant women and pregnancy care facilities.

“It’s not true that this law in any way protects Medicaid for pregnant mothers, for low-income parents. It adds financial strain to the providers and the insurance program that they rely on,” he said.

Sommers warned that some pregnant women are enrolled through Medicaid expansion rather than a pregnancy-specific category. If state authorities do not know that a beneficiary is pregnant, she may not be automatically protected from the new requirements.

“Someone could be enrolled through Medicaid expansion, they could get pregnant and they could mistakenly think – because they heard it on the news that this law doesn’t affect pregnant people – [they’re] fine, and it turns out the state doesn’t know they’re pregnant and they lose coverage."

Rural Communities At Risk

The consequences of maternity unit closures can impact other aspects other than childbirth. Pregnant women may have to travel farther for antenatal appointments, emergency obstetric care and delivery, adding transport costs and making timely treatment more difficult.

March of Dimes has identified 31 rural hospitals with labour and delivery services that could be at risk. If these units close, 96 counties could lose their remaining local delivery services, Jones warned. “Losing these services means fewer places to deliver safely and fewer options for pregnancies requiring specialized care,” she added.

The organisation’s 2026 report found that 34.6% of US counties were maternity care deserts, meaning they had no obstetric clinicians or birthing facilities. These areas are home to approximately 2.4 million women of reproductive age.

Tech entrepreneur Bryan Johnson is expanding his horizons in longevity health experiments to female physiology, including monitoring his girlfriend Kate Tolo’s nighttime clitoral engorgement.

The purpose is to understand how genital blood flow may give clues about female sexual function and cardiovascular health.

The experiment is part of his extensive effort to collate data on women’s health that could be channeled into useful biomarkers.

But while research suggests a connection between genital blood flow, sexual arousal and cardiometabolic health, tracking these changes during sleep may not be an established way to screen heart disease.

Bryan Johnson Is Tracking His Girlfriend's Clitoral Blood Flow

Bryan Johnson and Kate Tolo are in the process of creating a detailed health-monitoring program through their company, Immortals. Their aim is to improve in-depth understanding of female physiology.

The process is partly inspired by research on erectile dysfunction in men. As erections depend on healthy blood vessels, erectile dysfunction can sometimes help in the detection of cardiovascular disease.

In an interview discussing the project, Tolo explained the reasoning behind investigating genital blood flow in women. “Because the penis has smaller blood vessels than the rest of the body, and so it's the first thing to show up when problems happen. So it's all about blood flow. That's why it should work for women just as well as it works for men, because we have blood vessels too,” she said. Johnson also highlighted nighttime erections as a physiological measure worth studying.

However, the evidence linking male erectile dysfunction with cardiovascular risk is more established than the evidence for using female genital blood flow measurements as a cardiovascular monitoring tool.

Also read: Bryan Johnson Blames Sugary Cereals, Soda and Stress for His Autoimmune Disease; Shares Treatment Plan

What Does Clitoral Engorgement Reveal About Sexual Health?

The clitoris contains erectile tissue supplied by blood vessels. During sexual arousal, increased blood flow contributes to genital engorgement and physiological changes associated with sexual response.

Blood circulation is therefore one component of sexual function. Reduced genital blood flow or increased vascular resistance may be associated with difficulties involving arousal, lubrication or orgasm.

A small pilot study published in the International Journal of Impotence Research examined 27 women and found that clitoral tissue perfusion was linked with scores measuring sexual function, including arousal, lubrication, orgasm and satisfaction.

The findings indicate that genital blood supply may be relevant to understanding female sexual health. However, the study was small and did not establish that nighttime clitoral blood-flow monitoring can diagnose sexual dysfunction.

Sexual function is also influenced by hormones, medications, neurological health, psychological factors, relationships and underlying medical conditions. Blood flow alone cannot explain every aspect of sexual wellbeing.

Also read: Bryan Johnson's 90-Day Experiment Claims That Oxygen Therapy Could Beat Aging

Can Clitoral Blood Flow Reveal Cardiovascular Risk?

The endothelium, the inner lining of blood vessels, helps regulate circulation. Metabolic conditions like diabetes, insulin resistance, high cholesterol, and hypertension can affect vascular function, including genital tissues.

A 2024 review published in the European Journal of Preventive Cardiology, which included 54 studies and nearly 149,000 participants, also found that women with cardiovascular disease had a higher risk of female sexual dysfunction.

This supports a relationship between cardiovascular and sexual health, but it does not validate Johnson’s tracking method.

Nocturnal genital responses may provide useful information about physiology, but researchers would need to establish what constitutes a normal pattern, how measurements vary with sleep and hormonal cycles, and whether particular changes reliably predict disease. The approach would also need to be tested in larger populations.