A new study has found that a combination of two drugs could enhance the immune system to treat one of the most common types of cancer in the world, bowel cancer. Also known as colorectal cancer, despite its widespread presence, the treatment options for this condition are limited. What the study specifically found was that this procedure could shrink the tumours caused by this condition by around 60%.

What Are The Drugs Involved

The trial involved the use of two immunotherapy drugs, botancilimab and balstilumab. It is a monoclonal antibody that works to stimulate the body's immune system to attack cancer. The study is a rather significant find, as it’s the first time that a consistent and durable response to immunotherapy has been reported in patients with solid MSS mCRC tumours.

The study was divided into several phases for more than 6 months. In the US trial, around around 101 patients with microsatile stable metastatic colorectal (MSS-mCRC) tumours showed a decrease . Around 61% of the patients experienced tumour shrinkage or stabilization after combined treatment with votancilumab and balstilumab. When it comes to downsides, diarrhea and fatigue were found to be the most common side effects or side effects of this drug.

These results are interesting and open to exploration. To date, immunotherapy has not been effective in patients with CNS-mCRC tumors. This study demonstrates the potential of the combination of botenlimab and balstilimab in the treatment of CNS mCRC, providing new hope for people diagnosed with colon cancer.

What Could This Mean For Bowel Cancer Treatment In The Future

The study is currently in the final stages of clinical trials, and the US Food and Drug Administration (FDA) hopes to quickly gain approval for its use because of the importance of this area that affects many people. The efficiency shown demonstrates the potential of botansilimab to contribute to broad antitumor immunity.

All in all, the combination of botensilimab and balstilimab represents a promising new direction in the treatment of colorectal cancer. This breakthrough could improve conditions for many patients worldwide and lights a new hope in the fight against this common disease. The results of this study show the effectiveness of immunotherapy in this field and how its potential to transform cancer treatment can only grow in the years to come.

India's Alkem Laboratories is all set to launch a semaglutide injection, meant for weight-loss and diabetes patients, priced merely at weekly cost of Rs 450 - making it one of the cheapest options available in the market.

The patent for Novo Nordisk, the original maker of semaglutide, ended on March 20 and since then, numerous pharmaceutical companies have begun releasing their own versions of the blockbuster drug.

Alkem Laboratories's drug, marketed under the brand names Semasize, Obesema and Hepaglide in India, will is administered as a once-weekly subcutaneous injection and the organization has revealed a pre-filled disposable injection pen priced at Rs 1,800 for a month’s dosage.

Apart from the drug, Alkem is also offering a reusable injection pen for higher maintenance doses, allowing patients to replace only the medication cartridge instead of buying a new device each time in order to reduce long-term treatment costs and improving adherence.

The company has received approval from the Drug Controller General of India to manufacture and market semaglutide for Type 2 Diabetes Mellitus and chronic weight management, following a review of Phase 3 clinical trials conducted in India.

Other Semaglutide Injection Launches In India

Apart from this, NATCO Pharma became the first to introduce Semanat and Semafull for INR 1,290 per month and INR 1,750, about 90 per cent cheaper than Ozempic, costing INR 8,800 per month.

Eris Lifesciences also announced its plans to launch a multi-dose vial under the brand name Sundae at the same price. Dr. Reddy’s Laboratories, Sun Pharmaceutical Industries, and Glenmark Pharmaceuticals launched their generic versions of semaglutide. Dr. Reddy’s Obeda is priced at Rs 4,200 per month, available in 2 mg and 4 mg strengths.

Sun Pharmaceutical Industries will sell under the brand names Noveltreat (doses ranging from INR 900) and Sematrinity (doses ranging from INR 750). Meanwhile, Glenmark’s GLIPIQ vials range from Rs 325 to Rs 440 per week.

Zydus Lifesciences has also announced the launch of its generic version of semaglutide injection under the brand names SEMAGLYNTM, MASHEMATM, and ALTERMET. The average monthly cost of the treatment will be about Rs 2,200, the company said in a statement.

Semaglutide: Risks Vs Benefits

In people with type 2 diabetes, Harvard Health noted that the body's cells are resistant to the effects of insulin and the body does not produce enough insulin, or both. This is when GLP-1 agonists stimulate the pancreas to release insulin and suppress the release of another hormone called glucagon.

These drugs also act in the brain to reduce hunger and act on the stomach to delay emptying, so you feel full for a longer time. These effects can lead to weight loss, which can be an important part of managing diabetes.

Notably, semaglutide is not just a glucose-lowering drug, it improves weight and has proven cardiovascular, liver, and renal benefits.

Wider availability could therefore help reduce long-term complications such as heart disease and kidney failure. If used appropriately, this could indeed be a major step forward in total metabolic care, the experts said.

“The increasing affordability of GLP-1 receptor agonists is a double-edged development. On one hand, it significantly improves access for patients with obesity, type 2 diabetes, and high cardiovascular risk, conditions that are highly prevalent in India. These drugs have demonstrated meaningful benefits in weight reduction, glycemic control, and even cardiovascular risk reduction, which could translate into long-term public health gains,” Dr Vivek Bindal, Senior Director & Head, Bariatric and Robotic Surgery, at Max Healthcare, told HealthandMe.

A recent study published in The Lancet Psychiatry journal showed that Ozempic can also help tackle the burden of depression, anxiety, and self-harm in high-risk diabetic patients.

However, the benefits are conditional as it depends on appropriate prescribing, reliable product quality, and adequate patient monitoring, said Dr. Anoop Misra, who heads Delhi’s Fortis-C-DOC Centre for Diabetes and Endocrinology, told HealthandMe..

"These drugs should be strictly prescribed by qualified doctors and used only for therapeutic purposes, not for cosmetic weight loss,” Dr. Mohan said.

Urging for careful monitoring of side effects, the expert also called for more Indian data and strict pharmacovigilance.

“This also presents a great opportunity for India to make these drugs affordable and accessible to other developing countries across Asia and Africa,” the noted diabetologist said.

The experts also warned of “indiscriminate or unsupervised use” due to low cost.

This is particularly for cosmetic weight loss without proper medical evaluation, said Dr. Bindal.

“GLP-1 therapies are not ‘quick fixes’ -- they require careful patient selection, dose titration, and monitoring for side effects such as gastrointestinal intolerance or, rarely, pancreatitis,” he added.

However, the focus should remain on holistic obesity management, including lifestyle modification, rather than over-reliance on pharmacotherapy alone.

Meningitis cases in Kent has alerted many to take precautions. As per a BBC report, Mashaal Chugtai, 22, who studies laws in the University said that it feels like "Covid all over again". Amid this, a claim has been circulating that Prime Minister Sir Keir Starmer warned "the UK may need to go into lockdown as early as May if meningitis cases continue to escalate".

Some posts also include an additional quote, supposedly from Sir Keir, that says “I will do whatever it takes to keep the country safe over the election period, even if that means you can’t go outside”.

However, upon fact checking, it was found that Sir Keir made no such statement. Number 10 also confirmed to Full Fact that the Prime Minister did not make such claims and this appeared from a satirical Facebook page.

What Is Happening In The UK?

Meningitis outbreak in Kent University that infected a dozen of people have now further infected more people. The total number as of now is 27, as experts say that incubation period of the bacteria may lead to an increase in number of those who are sick.

The bug that causes the infection has been identified as the known strain of meningitis B and MenB vaccines will be offered to 5,000 students living in the University of Kent halls of residence in Cantebury. While several reports claim that parents are rushing to pharmacies to get their children vaccinated, due to which there is a shortage of the MenB vaccines, health secretary, Wes Streeting has denied any such claims. "There is actually plenty of stock of vaccine supply in the country," he said.

As per the UK Health Security Agency (UKHSA) official, people infected in Kent were the ones who visited a nightclub on 5,6 or 7 March. The officials, including NHS members and county council public health staff who have been tackling the outbreak believe that it has not been passed on to anyone outside the area. "All cases to date are linked to the current outbreak in Kent," said a UKHSA spokesperson, as reported by The Guardian.

Another official involved in the multi-agency response said, "We may have contained it. There are no cases popping up elsewhere that we know of – no cases that we know of outside the cluster – or not yet anyway. We are rolling out a vaccine and antibiotics and tracing contacts. So there’s nothing we’re not doing.”

Quickest-growing Meningitis Outbreak Ever

UKHSA chief executive Susan Hopkins said the outbreak "looks like a super-spreader" event with "ongoing spread" through universities' halls of residence. She added: "There will have been some parties particularly around this, so there will have been lots of social mixing. I can't yet say where the initial infection came from, how it's got into this cohort, and why it's created such an explosive amount of infections."

She further said that in her 35 years working in medicine, healthcare, and hospitals, "This is the most cases I've ever seen in a single weekend with this type of infection". She added: "It is the explosive nature that is unprecedented here - the number of cases in such a short space of time." She also remarked that this was the "quickest-growing outbreak" she has ever seen in her career.

What Is Meningitis?

Meningitis is a serious medical condition that affects the protective membranes covering the brain and spinal cord, the meninges. While fever is not always present, it is usually considered as one of the classic symptoms of meningitis. It is important to know the varied symptoms, causes, and treatments of meningitis for early diagnosis and proper management of the disease.

Meningitis is an infectious illness that brings about inflammation in the meninges. The most common cause of such inflammation is bacterial or viral infections, though other causes are also possible including fungal, parasitic, or non-infectious causes (autoimmune disease, head injury, or brain surgery). Meningitis may be caused by bacterial meningitis, which the Centers for Disease Control and Prevention (CDC) indicates can be so severe and bring about conditions like hearing loss, vision problems, and death if not received on time.

The end of patent on semaglutide, the active ingredient in popular weight loss drugs like Ozempic and Wegovy, in India has ushered in the way for cheaper generic -- up to 90 per cent lower than the original drug price.

HealthandMe spoke to various experts to understand whether the cheaper versions of semaglutide will spur better health for Indians, or whether the various side effects seen in Ozempic will also be translated to the low-priced drugs.

The patent for Novo Nordisk, the original maker of semaglutide, ended on March 20. On the same day, NATCO Pharma became the first to introduce Semanat and Semafull for INR 1,290 per month and INR 1,750 -- about 90 per cent cheaper than Ozempic, costing INR 8,800 per month. Eris Lifesciences also announced its plans to launch a multi-dose vial under the brand name Sundae at the same price.

Today, Dr. Reddy’s Laboratories, Sun Pharmaceutical Industries, and Glenmark Pharmaceuticals launched their generic versions of semaglutide.

Dr. Reddy’s Obeda is priced at Rs 4,200 per month, available in 2 mg and 4 mg strengths.

Sun Pharmaceutical Industries will sell under the brand names Noveltreat (doses ranging from INR 900) and Sematrinity (doses ranging from INR 750). Meanwhile, Glenmark’s GLIPIQ vials range from Rs 325 to Rs 440 per week.

Zydus Lifesciences has also announced the launch of its generic version of semaglutide injection under the brand names SEMAGLYNTM, MASHEMATM, and ALTERMET. The average monthly cost of the treatment will be about Rs 2,200, the company said in a statement.

Dr. V. Mohan, Chairman of Dr. Mohan's Diabetes Specialities Centre, Chennai, told HealthandMe called it a “very positive development” yet stressed the need to ensure “quality”.

According to a BBC report, around 50 branded semaglutide generics will enter the Indian market within months. How will this benefit Indians? Let's take a look.

Semaglutide works as a GLP-1 receptor agonist that mimics the GLP-1 hormone to regulate appetite and blood sugar. It slows gastric emptying and makes you feel fuller longer. It also signals the brain to reduce hunger and cravings, and triggers the pancreas to release insulin when blood sugar is high.

“For a country like India, which carries a large burden of Type 2 Diabetes and Obesity (and related complications), this could translate into meaningful clinical gains,” Dr. Anoop Misra, who heads Delhi’s Fortis-C-DOC Centre for Diabetes and Endocrinology, told HealthandMe.

India is facing an alarming diabetes epidemic, ranking second globally with an estimated 101 million people living with diabetes and another 136 million with prediabetes as of 2023, according to the ICMR-INDIAB study.

Similarly, the National Family Health Survey (NFHS) 2019–21 states that 24 percent of Indian women and 23 percent of Indian men are overweight or obese.

Also read: Ozempic Will Go Generic, Weight-loss Drug Cost Could Lower By 90%

Semaglutide: Risks Vs Benefits

In people with type 2 diabetes, Harvard Health noted that the body's cells are resistant to the effects of insulin and the body does not produce enough insulin, or both. This is when GLP-1 agonists stimulate the pancreas to release insulin and suppress the release of another hormone called glucagon.

These drugs also act in the brain to reduce hunger and act on the stomach to delay emptying, so you feel full for a longer time. These effects can lead to weight loss, which can be an important part of managing diabetes.

Notably, semaglutide is not just a glucose-lowering drug -- it improves weight and has proven cardiovascular, liver, and renal benefits.

Wider availability could therefore help reduce long-term complications such as heart disease and kidney failure. If used appropriately, this could indeed be a major step forward in total metabolic care, the experts said.

“The increasing affordability of GLP-1 receptor agonists is a double-edged development. On one hand, it significantly improves access for patients with obesity, type 2 diabetes, and high cardiovascular risk -- conditions that are highly prevalent in India. These drugs have demonstrated meaningful benefits in weight reduction, glycemic control, and even cardiovascular risk reduction, which could translate into long-term public health gains,” Dr Vivek Bindal, Senior Director & Head, Bariatric and Robotic Surgery, at Max Healthcare, told HealthandMe.

A recent study published in The Lancet Psychiatry journal showed that Ozempic can also help tackle the burden of depression, anxiety, and self-harm in high-risk diabetic patients.

However, the benefits are conditional -- it depends on appropriate prescribing, reliable product quality, and adequate patient monitoring, said Dr. Misra.

"These drugs should be strictly prescribed by qualified doctors and used only for therapeutic purposes, not for cosmetic weight loss,” Dr. Mohan said.

Urging for careful monitoring of side effects, the expert also called for more Indian data and strict pharmacovigilance.

“This also presents a great opportunity for India to make these drugs affordable and accessible to other developing countries across Asia and Africa,” the noted diabetologist said.

The experts also warned of “indiscriminate or unsupervised use” due to low cost.

This is particularly for cosmetic weight loss without proper medical evaluation, said Dr. Bindal.

“GLP-1 therapies are not ‘quick fixes’ -- they require careful patient selection, dose titration, and monitoring for side effects such as gastrointestinal intolerance or, rarely, pancreatitis,” he added.

However, the focus should remain on holistic obesity management, including lifestyle modification, rather than over-reliance on pharmacotherapy alone.

Also read: Semaglutide: Wegovy Can Spur Sudden Sight Loss By 5x; Men More At Risk, Finds Study

The major concerns around semaglutide include:

• Quality and manufacturing variability

Semaglutide is a complex peptide, unlike conventional small-molecule drugs. Variations in manufacturing, storage, or delivery devices may affect efficacy and safety.

• Cold-chain and storage issues

Maintaining 2-8°C across India’s diverse healthcare settings is challenging. Breaks in the cold chain could reduce drug effectiveness without being immediately apparent.

• Regulatory burden

With 40+ companies entering the market, ensuring uniform quality, batch consistency, and device reliability will stretch regulatory systems.

• Inadequate physician training

Many prescribers may lack experience with GLP-1 receptor agonists—particularly regarding dose titration, side-effect management, and patient selection.

• Pharmaceutical promotion vs. scientific education

• Indiscriminate or cosmetic use

There is a real risk of semaglutide being used for “quick weight loss” without proper medical supervision.

• Adverse effects and monitoring gaps

Gastrointestinal side effects, gallbladder disease, and rare pancreatitis require counselling and follow-up—often lacking in routine practice.

The greatest benefit will be seen in:

• Patients with Type 2 diabetes and overweight/obesity
• Individuals with poor glycemic control despite standard therapy
• Patients with high cardiovascular risk, or who have suffered heart attacks and strokes
• Those with metabolic syndrome or abdominal obesity
• Selected patients with chronic kidney disease
• People with obstructive sleep apnea (disordered breathing at night)
• People with severe fatty liver and consequent damage to the liver

"In these groups, semaglutide provides multidimensional benefit -- glucose lowering, weight reduction, and cardiometabolic protection," Dr. Misra said.

Who Should Avoid Semaglutide?

Semaglutide should be avoided or used with extreme caution in:

• Patients with a history of medullary thyroid carcinoma
• Individuals with a history of pancreatitis
• Those with severe gastrointestinal disease (e.g., gastroparesis)
• Pregnant or breastfeeding women
• Patients with Type 1 diabetes
• Patients with severe eye problems due to diabetes (can be taken with care)
• Individuals seeking purely cosmetic weight loss without a medical indication.