A new study has found that a combination of two drugs could enhance the immune system to treat one of the most common types of cancer in the world, bowel cancer. Also known as colorectal cancer, despite its widespread presence, the treatment options for this condition are limited. What the study specifically found was that this procedure could shrink the tumours caused by this condition by around 60%.

What Are The Drugs Involved

The trial involved the use of two immunotherapy drugs, botancilimab and balstilumab. It is a monoclonal antibody that works to stimulate the body's immune system to attack cancer. The study is a rather significant find, as it’s the first time that a consistent and durable response to immunotherapy has been reported in patients with solid MSS mCRC tumours.

The study was divided into several phases for more than 6 months. In the US trial, around around 101 patients with microsatile stable metastatic colorectal (MSS-mCRC) tumours showed a decrease . Around 61% of the patients experienced tumour shrinkage or stabilization after combined treatment with votancilumab and balstilumab. When it comes to downsides, diarrhea and fatigue were found to be the most common side effects or side effects of this drug.

These results are interesting and open to exploration. To date, immunotherapy has not been effective in patients with CNS-mCRC tumors. This study demonstrates the potential of the combination of botenlimab and balstilimab in the treatment of CNS mCRC, providing new hope for people diagnosed with colon cancer.

What Could This Mean For Bowel Cancer Treatment In The Future

The study is currently in the final stages of clinical trials, and the US Food and Drug Administration (FDA) hopes to quickly gain approval for its use because of the importance of this area that affects many people. The efficiency shown demonstrates the potential of botansilimab to contribute to broad antitumor immunity.

All in all, the combination of botensilimab and balstilimab represents a promising new direction in the treatment of colorectal cancer. This breakthrough could improve conditions for many patients worldwide and lights a new hope in the fight against this common disease. The results of this study show the effectiveness of immunotherapy in this field and how its potential to transform cancer treatment can only grow in the years to come.

Two orphaned babies have died of Ebola in the Democratic Republic of Congo, in an outbreak that could rival the worst on record.

Baby Buswaza was brought to a church-run orphanage in eastern Congo after her mother died in late May. The newborn was running a fever and, within days, died from what was later found to be Ebola, Reuters reported.

Buswaza was buried in late May in a sealed, waterproof body bag to prevent the spread of the disease.

More Suspected Cases at Orphanage

Six more babies have been identified as suspected Ebola cases at the orphanage of 69 children in Bunia, a city in Ituri province at the epicentre of the outbreak in Congo.

They were taken to hospital, where five of them later tested negative and were discharged from an isolation tent at the Evangelical Medical Centre (CME) by medics.

Another baby—an orphaned triplet girl nicknamed "Cherie" or "darling" who was less than a year old—with confirmed Ebola died on June 10, Dr. Freddy Kibwana, head of the CME, told Reuters. "The child has left us," he said.

How Children Can Be at Risk of Ebola

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Children and babies can easily become vectors for the disease through bodily fluids like vomit, faeces and saliva, which are highly infectious when people have Ebola.

"This epidemic has hit an area already in humanitarian crisis," said Babou Rukengeza, a senior health adviser with Save the Children aid group. "This place is the only refuge for these children."

“This outbreak is moving at a terrifying speed. I have responded to several Ebola outbreaks over the years, but this is the fastest spread I have ever seen. Children are paying a devastating price," he added.

The expert noted that “when parents die, children suddenly lose the biggest support system they could possibly have and face fear, grief, stigma, and social exclusion".

Can Ebola Be Passed From Mother to Child?

In addition to fluids like blood and saliva, Ebola has also been detected in amniotic fluid and the placenta, as per the World Health Organization, so it is possible Buswaza's mother transmitted the virus to her in the womb or during childbirth.

If the mother caught the virus after giving birth, she may also have transmitted it to her child through breastmilk, where the virus has also been detected.

Ebola Cases And Death Toll Climb

According to the US CDC, the confirmed cases in Congo have risen to 635, while there are 127 confirmed deaths. In Uganda, there are 19 confirmed cases and two confirmed deaths, along with one probable case and one probable death.

Using genetic fingerprinting, the illnesses have been identified as Bundibugyo virus, one of the four types of orthoebolaviruses that cause Ebola disease in people. There is no vaccine for Bundibugyo virus, and treatment consists of supportive care.

Ebola Outbreak: WHO Raises Risk Assessment

Meanwhile, the WHO has revised the risk assessment in Congo and Uganda. The risk has been revised to “very high at the national level in DRC and high for Uganda,” the WHO said.

It is also high for countries sharing land borders with DRC and Uganda, while low for the rest of the Africa region and at the global level.

The WHO explained that the risk in DRC remains very high because “the outbreak has continued to expand rapidly in terms of numbers of cases and geographical spread with more areas affected. Epidemiological links and the full chain of transmission are not yet clearly established, and the source of the outbreak remains under investigation”.

Moreover, the ongoing conflict is restricting movement of frontline responders and surveillance teams, while community fear and misinformation are hindering case detection, contact tracing and isolation, and potentially facilitating disease spread.

There are also other challenges such as limited healthcare infrastructure and delays in laboratory confirmation, although these are being scaled up by DRC with support from partners, the WHO said.

Health authorities in Kerala have reported a positive case of Nipah virus infection in a man from Kozhikode, triggering precautionary measures across the district.

The patient tested positive in a preliminary test conducted in Kozhikode and is currently undergoing treatment at Kozhikode Medical College Hospital, officials said.

With the fresh scare, health authorities have initiated extensive contact tracing and surveillance measures to prevent any potential spread of the infection.

According to officials, the patient arrived at the hospital through the outpatient department and is believed to have interacted with several people before being identified as a suspected Nipah case.

While the initial test indicated the presence of the virus, confirmation from a specialized virology laboratory is still awaited. Despite the pending confirmatory result, the state government has activated containment protocols as a precaution. Close contacts of the patient are being identified, monitored, and assessed as part of the standard public health response.

Kerala Health Minister Says No Need for Panic

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Kerala Health Minister K. Muralidharan said the patient had extensive contacts but stressed that there was no reason for panic at this stage. The minister noted that the patient had visited multiple departments of the private hospital where he first sought treatment, raising concerns about possible exposure to others.

As a precautionary measure, hospital staff who may have come into contact with the patient have been asked to undergo quarantine and monitoring.

What Is Nipah Virus?

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According to the World Health Organization, Nipah virus is a zoonotic disease, meaning it can spread from animals to humans. It can also be transmitted through contaminated food and, in some cases, directly from person to person.

In humans, Nipah infection can range from asymptomatic illness to severe respiratory disease and fatal encephalitis (brain inflammation). The virus can also infect animals such as pigs, causing significant economic losses for farmers.

Although only a limited number of outbreaks have been reported in Asia, the virus is known for its high fatality rate and potential to cause severe disease.

How Does Nipah Spread?

• Animal-to-Human Transmission: During the first recognized outbreak in Malaysia, which also affected Singapore, most human infections were linked to direct contact with infected pigs or their contaminated tissues. Transmission was believed to occur through exposure to respiratory secretions or bodily fluids of infected animals.

• Bat-Contaminated Food: In later outbreaks in Bangladesh and India, the most likely source of infection was the consumption of fruits or fruit products—particularly raw date palm sap—contaminated by saliva or urine from infected fruit bats.

• Human-to-Human Transmission: Human-to-human transmission has also been documented, particularly among family members and healthcare workers caring for infected patients.

Nipah Virus: Symptoms

Symptoms of Nipah virus infection may include:

• Fever
• Headache
• Breathing difficulties
• Cough and sore throat
• Diarrhea
• Vomiting
• Muscle pain
• Severe weakness
• Dizziness
• Altered consciousness in severe cases
• Encephalitis (brain inflammation)

Why Is Nipah A Concern?

Nipah virus is considered a major public health threat because of its high mortality rate, ability to spread through close contact, and the absence of a specific antiviral treatment or approved vaccine for widespread use.

Early detection, isolation of suspected cases, contact tracing, and strict infection-control measures remain the most effective tools for preventing outbreaks.

A federally commissioned study that concluded even low levels of alcohol consumption may increase the risk of disease and premature death has now been published in a scientific journal after its findings were set aside by the Trump administration.

The study, known as the Alcohol Intake and Health Study, was commissioned as part of an effort to update the United States Dietary Guidelines. Researchers concluded that consuming as little as one alcoholic drink per day could raise the risk of serious illness and mortality.

However, the report was never officially released by the administration and later became the subject of political and industry scrutiny.

Why Was the Study Not Released?

Launched in 2023, the Alcohol Intake and Health Study was overseen by the Substance Abuse and Mental Health Services Administration (SAMHSA).

The review aimed to inform recommendations on alcohol consumption in the next edition of the federal dietary guidelines. But soon the study garnered controversy with some members of Congress and alcohol lobby groups arguing that scientists involved in the review held anti-alcohol views, according to Stat News.

As per a House Oversight Committee report, released in January, the study was "irretrievably flawed". It recommended that federal officials disregard its findings when drafting dietary guidance.

However, researchers involved in the project argued that the findings were sidelined because they conflicted with the interests of the alcohol industry.

What Did The Study Find?

Also read: Is There A Safe Limit For Alcohol Consumption? Major Review Challenges Long-Held Beliefs

After the federal review was shelved, researchers submitted their work independently to the Journal of Studies on Alcohol and Drugs, where it was published following peer review.

The published analysis concluded that even modest alcohol consumption — roughly one drink per day — is associated with increased risks of disease and death.

“These findings are not radical. They are rigorous — and commercially threatening,” wrote Robert Vincent, a former SAMHSA associate administrator for alcohol prevention and treatment policy, in an accompanying editorial.

Vincent, who helped oversee the project, lost his position during broader cuts across federal health agencies last year, the report said.

Notable, the US Department of Health and Human Services (HHS) has stated that the now published article was not the same report reviewed by the government and emphasized that it was not commissioned, approved, or cleared by SAMHSA.

Alcohol Guidance Changed

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Federal officials said they reviewed a broad range of scientific evidence when updating the nation's dietary recommendations.

New dietary guidelines released in January marked a significant shift in alcohol messaging. Rather than recommending specific daily limits, the guidance now advises Americans to “consume less alcohol for better overall health.”

According to HHS, the recommendation was based on a separate scientific review rather than the SAMHSA-led report.