A new study has found that a combination of two drugs could enhance the immune system to treat one of the most common types of cancer in the world, bowel cancer. Also known as colorectal cancer, despite its widespread presence, the treatment options for this condition are limited. What the study specifically found was that this procedure could shrink the tumours caused by this condition by around 60%.

What Are The Drugs Involved

The trial involved the use of two immunotherapy drugs, botancilimab and balstilumab. It is a monoclonal antibody that works to stimulate the body's immune system to attack cancer. The study is a rather significant find, as it’s the first time that a consistent and durable response to immunotherapy has been reported in patients with solid MSS mCRC tumours.

The study was divided into several phases for more than 6 months. In the US trial, around around 101 patients with microsatile stable metastatic colorectal (MSS-mCRC) tumours showed a decrease . Around 61% of the patients experienced tumour shrinkage or stabilization after combined treatment with votancilumab and balstilumab. When it comes to downsides, diarrhea and fatigue were found to be the most common side effects or side effects of this drug.

These results are interesting and open to exploration. To date, immunotherapy has not been effective in patients with CNS-mCRC tumors. This study demonstrates the potential of the combination of botenlimab and balstilimab in the treatment of CNS mCRC, providing new hope for people diagnosed with colon cancer.

What Could This Mean For Bowel Cancer Treatment In The Future

The study is currently in the final stages of clinical trials, and the US Food and Drug Administration (FDA) hopes to quickly gain approval for its use because of the importance of this area that affects many people. The efficiency shown demonstrates the potential of botansilimab to contribute to broad antitumor immunity.

All in all, the combination of botensilimab and balstilimab represents a promising new direction in the treatment of colorectal cancer. This breakthrough could improve conditions for many patients worldwide and lights a new hope in the fight against this common disease. The results of this study show the effectiveness of immunotherapy in this field and how its potential to transform cancer treatment can only grow in the years to come.

Nipah virus outbreak has triggered screenings at the airport. After two cases were reported in India's West Bengal, concerns have sparked in many parts of Asia, and measures at airports have been tightened.

Thailand has begun screening passengers at three airports that handle flights from West Bengal. Nepal has also stepped up checks, screening arrivals at Kathmandu airport as well as at several land border crossings with India.

In West Bengal, five healthcare workers were infected earlier this month, with one reported to be in critical condition. Around 110 people who came into contact with them have since been placed under quarantine.

Nipah virus spreads from animals to humans and carries a high fatality rate, estimated to be between 40 percent and 75 percent. At present, there is no approved vaccine or specific treatment for the infection.

What Is Nipah Virus?

As per the World Health Organization (WHO), Nipah virus infection is a zoonotic illness that is transmitted to people from animals, and can also be transmitted through contaminated food or directly from person to person.

In infected people, it causes a range of illnesses from asymptomatic (subclinical) infection to acute respiratory illness and fatal encephalitis. The virus can also cause severe disease in animals such as pigs, resulting in significant economic losses for farmers.

Although Nipah virus has caused only a few known outbreaks in Asia, it infects a wide range of animals and causes severe disease and death in people.

Read: Nipah Virus Outbreak In India: How Did It All Begin?

During the first recognized outbreak in Malaysia, which also affected Singapore, most human infections resulted from direct contact with sick pigs or their contaminated tissues. Transmission is thought to have occurred via unprotected exposure to secretions from the pigs, or unprotected contact with the tissue of a sick animal.

In subsequent outbreaks in Bangladesh and India, consumption of fruits or fruit products (such as raw date palm juice) contaminated with urine or saliva from infected fruit bats was the most likely source of infection.

Human-to-human transmission of Nipah virus has also been reported among family and care givers of infected patients.

Nipah Virus Symptoms

• Fever
• Headache
• Breathing difficulties
• Cough and sore throat
• Diarrhea
• Vomiting
• Muscle pain and severe weakness

Nipah virus outbreak in India has led to nearly 100 people being quarantined. India is facing Nipah virus cases and contagion every year now. Experts are now cautioning people against the zoonotic nature of the viral infection. Rajeev Jayavedan, the former president of Indian Medical Association, Cochin, told The Independent, that infection among humans are rare and caused by the accidental spillover due to human-bat interface, which means consumption of fruits that may have been infected by bats. “This is more likely in rural and forest-adjacent areas where agricultural practices increase contact between humans and fruit bats searching for food,” he said.

Health and Me previously reported on how doctors are now advising people to be cautious while eating food. Speaking to TOI, Dr Aishwarya R, Consultant, Infectious Diseases at Aster RV Hospital advised people against eating certain food, including fruits fallen from trees, unpasteurized date palm sap and any other fruits without washing. The doctor explained that this infection can spread with infected animal who could bite fruits and spread the virus through their saliva.

Chinese officials are sounding the alarm over the outbreak of the highly fatal Nipah virus in West Bengal and demanding travel restrictions before the Lunar New Year on February 17.

Earlier this month, two hospital nurses at AIIMS, Kolkata, had tested positive for the infection and were quarantined, prompting widespread testing. As of January 24, five cases, including a doctor and a staff member, were confirmed and nearly 100 people have been quarantined.

While health officials state it is nearly impossible for the virus to transmit across countries and unlikely to cause an outbreak in China, a majority of the public remains concerned as the disease has a fatality rate of up to 75 percent and no effective treatment or vaccines are available.

Also Read: Nipah Virus Outbreak In India: How Did It All Begin?

“It’s so scary, especially with the Spring Festival coming up. I don’t want to experience another lockdown,” a Chinese citizen said online, referring to the Lunar New Year holiday. Another asked, “Can’t we temporarily shut the travel channel with India?”, according to the South China Morning Post.

As of late 2025, India has lifted major travel restrictions on Chinese nationals, with tourist e-visas, business visas and direct flights fully resumed after a five-year suspension due to the 2020 border clashes, according to the Ministry of External Affairs.

The visa regime is fully functional, allowing Chinese citizens to apply for up to 5-year, multiple-entry e-TVs.

Nipah Virus: What Is It And What Are The Symptoms?

As per the World Health Organization (WHO), Nipah virus infection is a zoonotic illness that is transmitted to people from animals and can also be transmitted through contaminated food or directly from person to person.

In infected people, it causes a range of illnesses from asymptomatic (subclinical) infection to acute respiratory illness and fatal encephalitis. The virus can also cause severe disease in animals such as pigs, resulting in significant economic losses for farmers.

Although Nipah virus has caused only a few known outbreaks in Asia, it infects a wide range of animals and causes severe disease and death in people. Some of its common symptoms include:

• Fever
• Headache
• Breathing difficulties
• Cough and sore throat
• Diarrhea
• Vomiting
• Muscle pain and severe weakness

In 2018, another outbreak occurred in Kerala, India, where 23 confirmed and suspected cases were reported. The virus spread across three hospitals, with both primary and secondary infections traced back to one initial patient.

Samples collected from the patient’s home and workplaces, including pets and partially eaten fruits dropped by bats, all tested negative for the virus, and the exact source of the infection could not be identified.

What Do Doctors Say?

Experts are now cautioning people against the zoonotic nature of the viral infection. Rajeev Jayavedan, the former president of the Indian Medical Association, Cochin, told The Independent, that infection among humans are rare and caused by the accidental spillover due to the human-bat interface, which means consumption of fruits that may have been infected by bats.

“This is more likely in rural and forest-adjacent areas where agricultural practices increase contact between humans and fruit bats searching for food,” he said.

Health and Me previously reported on how doctors are now advising people to be cautious while eating food. Speaking to TOI, Dr Aishwarya R, Consultant, Infectious Diseases at Aster RV Hospital advised people against eating certain food, including fruits fallen from trees, unpasteurized date palm sap and any other fruits without washing. The doctor explained that this infection can spread with an infected animal which could bite fruits and spread the virus through their saliva.

Cancer screening for UK's second deadliest cancer is undergoing some changes, as NHS UK lowers the threshold of bowel cancer test. What it means is that NHS England is lowering the threshold of the amount of blood detected through a Fit or Fecal immunochemical test, needed to trigger the patient being sent for further investigation.

What Is the Fit Test?

The fecal immunochemical test is used to detect bowel cancer by spotting blood in the patient's stool. As per the new NHS guidelines, the sensitivity of the Fit test will be increase as part of an overhaul of cancer diagnosis as well as treatment.

Also Read: Nipah Virus Outbreak In India: How Did It All Begin?

As of now, it stands at 120 micrograms of blood a gram of stool, however, it will be reduced to 80 microgram by 2028. This will bring England into line with threshold that are already followed in Scotland and Wales.

“This is a major step forward in bowel cancer detection and will help save hundreds more lives from this devastating disease,” said Prof Peter Johnson, NHS England’s national clinical director for cancer. “Testing at a lower level threshold will now provide a better early warning system for bowel cancer, helping us to spot and treat cancers earlier, often picking up problems before symptoms occur," as reported by The Guardian.

Bowel Cancer In The UK

Around 44,100 people in the UK are diagnosed with bowel cancer each year, and about 17,400 die from the disease, making it the second leading cause of cancer deaths. Risk factors include processed meat consumption, excess weight and alcohol use. Cancer Research UK estimates that 54 percent of cases could be prevented. “Once fully implemented testing at the lower level threshold is expected to reduce late stage diagnoses and deaths from bowel cancer by around 6%,” NHS England said.

Read: Colorectal Cancer Is The Leading Cause Of Cancer Death In American Men Under 50

The estimate suggests that improving prevention and earlier detection could save the health service £32 million each year. The change is expected to result in around 600 additional bowel cancer diagnoses annually in England, an 11 percent rise on top of the 5,320 cases currently identified each year through the existing test.

Under the changes, the NHS is expected to carry out 35 percent more colonoscopies for patients flagged as high risk by the Fit test. Introduced in 2019, the Fit test is a home screening programme in which eligible people receive a kit by post, return a small stool sample, and have it analyzed in a laboratory.

The expansion will be detailed in the government’s new national cancer plan, set to be launched on 4 February, which cancer groups observe as World Cancer Day. In England, eligibility was widened in 2024 to include people aged 50 to 53, down from the earlier range of 54 to 74. During 2023–24, nearly seven million kits were sent out, with 68 percent returned, leading to the detection of 5,320 cancers. With the broader age criteria, an additional 1.2 million people are now being offered the test.

What Is Bowel Cancer?

The Cancer Council notes that bowel cancer is also called the colorectal cancer, colon cancer or rectal cancer, which develops in the inner lining of the bowel. It is preceded by growths called polyps, which could become invasive cancer if undetected.