A new study has found that a combination of two drugs could enhance the immune system to treat one of the most common types of cancer in the world, bowel cancer. Also known as colorectal cancer, despite its widespread presence, the treatment options for this condition are limited. What the study specifically found was that this procedure could shrink the tumours caused by this condition by around 60%.
What Are The Drugs Involved
The trial involved the use of two immunotherapy drugs, botancilimab and balstilumab. It is a monoclonal antibody that works to stimulate the body's immune system to attack cancer. The study is a rather significant find, as it’s the first time that a consistent and durable response to immunotherapy has been reported in patients with solid MSS mCRC tumours.
The study was divided into several phases for more than 6 months. In the US trial, around around 101 patients with microsatile stable metastatic colorectal (MSS-mCRC) tumours showed a decrease . Around 61% of the patients experienced tumour shrinkage or stabilization after combined treatment with votancilumab and balstilumab. When it comes to downsides, diarrhea and fatigue were found to be the most common side effects or side effects of this drug.
These results are interesting and open to exploration. To date, immunotherapy has not been effective in patients with CNS-mCRC tumors. This study demonstrates the potential of the combination of botenlimab and balstilimab in the treatment of CNS mCRC, providing new hope for people diagnosed with colon cancer.
What Could This Mean For Bowel Cancer Treatment In The Future
The study is currently in the final stages of clinical trials, and the US Food and Drug Administration (FDA) hopes to quickly gain approval for its use because of the importance of this area that affects many people. The efficiency shown demonstrates the potential of botansilimab to contribute to broad antitumor immunity.
All in all, the combination of botensilimab and balstilimab represents a promising new direction in the treatment of colorectal cancer. This breakthrough could improve conditions for many patients worldwide and lights a new hope in the fight against this common disease. The results of this study show the effectiveness of immunotherapy in this field and how its potential to transform cancer treatment can only grow in the years to come.
Credit: iStock
The US Food and Drug Administration (FDA) has identified a new Cyclospora outbreak, which is not related to ongoing outbreaks in the country causing watery diarrhea and hospitalizations among thousands.
The agency said the outbreak has sickened 72 people and is linked to an unspecified product. The FDA said the source has "not yet been identified."
The announcement comes as the US continues to report one of its largest cyclospora outbreaks. According to the US Centers for Disease Control and Prevention (CDC), there have been 4,173 laboratory-confirmed and domestically acquired cases of cyclosporiasis across 41 states since May 1.
A total of 308 people with confirmed infections have been hospitalized, but no deaths have been reported.
The CDC also reported 767 travel-associated cases during the same period, resulting in 33 hospitalizations and no deaths. These cases were linked to contaminated food or water consumed outside the US.
According to the Michigan Department of Health and Human Services, a Cyclospora outbreak linked to iceberg lettuce distributed by Taylor Farms has sickened 7,664 people across Indiana, Kentucky, Michigan, Ohio and West Virginia, with 160 hospitalizations.
Michigan has reported about 7,000 cases, while Ohio has recorded nearly 3,500 cases, according to the Toledo-Lucas County Health Department.
“I want to stress that our investigation continues, including into other potential sources and commodities for other clusters of illness,” said Kyle Diamantas, acting FDA commissioner. Meanwhile, Health and Human Services Secretary Robert F. Kennedy Jr. this week said the outbreak is “under control.”
Also read: Cyclospora Parasite Outbreak: Why You Should Avoid Packaged Salads and Go For Loose Greens
According to experts, Cyclospora infection caused by the parasite Cyclospora cayetanensis is much harder to trace than common foodborne bacteria such as E. coli and Salmonella.
Investigators typically use DNA fingerprinting to connect bacterial infections to contaminated food through laboratory networks such as PulseNet. However, this method is much less effective for Cyclospora because the parasite has a more complex genetic makeup, making it difficult to link infections to a single food item or supplier.
Dr. Max Teplitski, former head of the Division of Food Safety at the US Department of Agriculture and now chief science officer at the International Fresh Produce Association, said the parasite remains one of the most difficult foodborne pathogens to investigate, contributing to delays in identifying the outbreak source, CNN reported.
Read More: Cyclospora Parasite Spreads to More US States: Foods to Avoid Right Now
The CDC recommends the following steps to reduce the risk of infection:
Cyclospora spreads through food or water contaminated with human feces and is not transmitted directly from person to person.
Dr. Darien Sutton, an emergency medicine physician and ABC News medical correspondent, emphasized that alcohol-based hand sanitizers are ineffective against the parasite. "This type of parasite doesn't easily go away with alcohol-based hand sanitizer. So, good old handwashing is really key here," Sutton said.
Credit: AI generated
A relentless heatwave is sweeping across parts of Europe, Asia, and Africa, pushing temperatures to dangerous levels and triggering widespread disruptions.
While France and Japan are battling scorching conditions and issuing health alerts, extreme heat in parts of Africa has reportedly killed camels, highlighting the growing human, environmental, and economic toll of intensifying climate extremes.
In addition, countries including Spain, Italy, Greece, Portugal and Germany are also battling extreme heat and wildfire threats, while climate change is worsening wildfire risks in the US and Canada.
A deadly heatwave in France in late June led to 5,764 excess deaths, according to updated data released by the country's public health agency.
The revised analysis found that 21,674 people died between June 17 and July 2, compared with the 15,910 deaths normally expected during the same period—a 36% increase in mortality.
Japan is also grappling with extreme temperatures. More than 450 people were taken to hospitals for heat-related illnesses in a single day in Tokyo—the highest daily figure since records began 16 years ago, emergency services said.
The update comes as the country endures a heatwave that has killed at least 14 people over the past week.
The UK has issued yellow heat health alerts across central and southern England, with temperatures forecast to reach 30°C (86°F).
The UK Health Security Agency (UKHSA) warned that the heat is expected to cause minor impacts on health and social care services while increasing risks for vulnerable people. The alerts remain in effect through Sunday as parts of the country continue to experience prolonged dry weather and drought conditions.
Read More: Europe Heatwave Causes 10,000 Excess Deaths; England, Wales Record 2,700 More Fatalities
Camels, long regarded as the "ships of the desert," are also struggling with extreme heat in Africa.
The BBC reported that camel shepherds in Ethiopia's Afar region have observed blisters on camels' feet, watery eyes, and skin burns caused by scorching sand.
Research from Somalia found drought-related camel mortality affected nearly 46% of camel-owning households, while another study from Algeria reported a significant rise in camel deaths during summer heatwaves.
Scientists say prolonged heat and drought cause stress, dehydration, disease, and reduce access to water and vegetation essential for camel survival.
According to the Copernicus Climate Change Service (C3S), June 2026 was the hottest June ever recorded for western Europe and the second warmest globally.
The World Meteorological Organization (WMO) said the heat has continued into July, fuelling wildfires in France and the Iberian Peninsula. Spain's Fabra Observatory recorded 40.5°C on July 8, the highest temperature in more than a century of observations.
"Heatwaves like this are what we expect to see in a changing climate," said John Kennedy, head of climate information at WMO.
"In the 50 years since the historic heatwave in 1976, Europe as a whole has warmed by around two degrees. It's one of the fastest warming continents and extremes of temperature have increased too."
Heat is often called the "silent killer," with an estimated 489,000 heat-related deaths each year between 2000 and 2019.
"Prolonged exposure over several days, particularly when temperatures remain high at night, means the body enters each new day already stressed," said Lachlan McIver, Health Advisor at the WHO-WMO Climate and Health Joint Office.
According to scientists, climate change is driving increasingly severe heatwaves. A recent study by the Potsdam Institute for Climate Impact Research found that warming ocean waters account for 50–64% of the increase in land heatwaves globally.
Credit: Instagram
American R&B singer and songwriter Nivea has revealed that she is battling leukemia, a type of blood cancer that originates in the bone marrow, where the body produces blood cells.
The 44-year-old singer shared the news during an appearance on the Cadillac Chronicles interview series.
"I was diagnosed with leukemia earlier this year, and I am so grateful to God," she said. "I've been going through treatment and everything is going great so far. And I expect it to continue. Amen. Amen. Amen. And I'm very grateful for life. It's so cliché to say, you know, you don't know the time nor the hour, and it's true."
She said living with gratitude has helped her through the diagnosis.
"I'm definitely back into my music. I'm going to school for audio engineering. I've always wanted to learn how to engineer and mix engineer in particular. But in general, just doing all the things, honey. Loving on my children and just being grateful."
Nivea rose to prominence in the early 2000s with a string of hit singles and earned a Grammy Award nomination for "Don't Mess With My Man."
According to the Mayo Clinic, leukemia is a cancer of the body's blood-forming tissues, including the bone marrow and the lymphatic system.
It usually affects white blood cells, which are responsible for fighting infections. In people with leukemia, the bone marrow produces excessive abnormal white blood cells that do not function properly.
Treatment for leukemia depends on the type of leukemia and other factors, but several therapies are available to help manage the disease.
The four main types of leukemia are:
Nivea has not disclosed which type of leukemia she has.
Symptoms vary depending on the type of leukemia but commonly include:
Leukemia is the 10th most common cancer in the United States, accounting for about 3.2% of all new cancer cases.
Globally, leukemia cases increased by 28% between 1990 and 2021, according to the Global Burden of Disease Study 2021 (GBD 2021).
An estimated 1.71 million people were living with leukemia worldwide in 2021. The disease is most commonly diagnosed in children aged 0-4 years and adults aged 70 years and older.
While anyone can develop leukemia, certain factors may increase the risk:
Treatment depends on the type of leukemia, the patient's age and overall health, and whether the cancer has spread. Common treatment options include:
© 2024 Bennett, Coleman & Company Limited