A new study has found that a combination of two drugs could enhance the immune system to treat one of the most common types of cancer in the world, bowel cancer. Also known as colorectal cancer, despite its widespread presence, the treatment options for this condition are limited. What the study specifically found was that this procedure could shrink the tumours caused by this condition by around 60%.

What Are The Drugs Involved

The trial involved the use of two immunotherapy drugs, botancilimab and balstilumab. It is a monoclonal antibody that works to stimulate the body's immune system to attack cancer. The study is a rather significant find, as it’s the first time that a consistent and durable response to immunotherapy has been reported in patients with solid MSS mCRC tumours.

The study was divided into several phases for more than 6 months. In the US trial, around around 101 patients with microsatile stable metastatic colorectal (MSS-mCRC) tumours showed a decrease . Around 61% of the patients experienced tumour shrinkage or stabilization after combined treatment with votancilumab and balstilumab. When it comes to downsides, diarrhea and fatigue were found to be the most common side effects or side effects of this drug.

These results are interesting and open to exploration. To date, immunotherapy has not been effective in patients with CNS-mCRC tumors. This study demonstrates the potential of the combination of botenlimab and balstilimab in the treatment of CNS mCRC, providing new hope for people diagnosed with colon cancer.

What Could This Mean For Bowel Cancer Treatment In The Future

The study is currently in the final stages of clinical trials, and the US Food and Drug Administration (FDA) hopes to quickly gain approval for its use because of the importance of this area that affects many people. The efficiency shown demonstrates the potential of botansilimab to contribute to broad antitumor immunity.

All in all, the combination of botensilimab and balstilimab represents a promising new direction in the treatment of colorectal cancer. This breakthrough could improve conditions for many patients worldwide and lights a new hope in the fight against this common disease. The results of this study show the effectiveness of immunotherapy in this field and how its potential to transform cancer treatment can only grow in the years to come.

Atherosclerosis, in which plaque builds up inside the arteries, is a major cause of cardiovascular disease and can lead to heart attacks, strokes and sudden death. A new study published in The New England Journal of Medicine found that plaque buildup can begin decades before symptoms appear.

An international team of researchers found atherosclerosis in many apparently healthy young adults, including those in their 20s.

Dr Borja Ibáñez, Scientific Director of the Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), said the findings point to a new approach to cardiovascular prevention: detecting atherosclerosis through imaging before symptoms appear, rather than relying only on risk factors such as blood pressure, cholesterol and smoking.

Plaque Can Appear In The 20s

The study included 16,808 people aged 18 to 70 from Denmark and Spain. None had a known history of atherosclerotic cardiovascular disease.

Using advanced imaging, researchers examined the carotid, femoral and coronary arteries for plaque. Overall, 57.1% of participants had atherosclerotic plaques, despite having no symptoms or previous diagnosis of cardiovascular disease.

Atherosclerosis was detectable even among the youngest participants. Among those aged 18 to 29, plaque was found in:

• 8.7% of men
• 6.7% of women

The prevalence increased with age, reaching nearly 90% among people aged 60 to 70. By 60–70, only about 1.9% of men and 8.1% of women had no detectable plaque in any of the arteries examined.

Men Develop Plaque Earlier

The study found differences between men and women. Atherosclerosis began increasing at younger ages in men, with their atherosclerotic profile appearing five to 10 years earlier than in women.

In women, the sharpest increase occurred between 40 and 60, broadly coinciding with the menopausal transition.

Could Ultrasound Detect Silent Atherosclerosis?

Conventional cardiovascular risk scores, including SCORE2, identified only a small proportion of people who already had silent atherosclerosis.

Researchers found that people with coronary artery plaque often also had plaque in the carotid or femoral arteries. Because these arteries can be examined using relatively simple, non-invasive ultrasound, the finding could have implications for future screening.

Dr. Ibáñez said portable ultrasound devices could potentially become a tool for detecting atherosclerosis from early adulthood.

“The future of cardiovascular prevention must be more precise and personalized,” he said, adding that early detection could allow earlier intervention and more targeted treatment.

Plaque Does Not Mean A Heart Attack Is Imminent

Dr. Sudhir Kumar, neurologist at Apollo Hospitals, Hyderabad, said atherosclerosis can remain silent for decades before causing a heart attack, ischemic stroke or peripheral arterial disease.

However, having plaque does not mean a heart attack or stroke is imminent. Greater plaque burden and more widespread disease are associated with higher cardiovascular risk.

He also stressed that atherosclerosis is not simply an unavoidable consequence of ageing. Its progression can be slowed by addressing modifiable risk factors.

How To Lower Cardiovascular Risk

• Regular aerobic and strength exercise
• Avoiding tobacco
• Eating a healthy diet and limiting ultra-processed foods
• Controlling blood pressure
• Managing LDL cholesterol/ApoB when indicated
• Preventing and treating diabetes
• Maintaining a healthy waist
• Getting adequate sleep.

15-year-old Tanvi Pariyani’s death at AIIMS Delhi has raised questions about the treatment of a rare and complex congenital heart condition she had been living with since childhood.

Tanvi, from Kota, had been visiting AIIMS since she was two. Her medical records listed ventricular septal defect (VSD) with pulmonary atresia, a combination that can make treatment considerably more complicated than just a 'hole in the heart'.

Tanvi’s family has alleged that corrective surgery was repeatedly postponed. AIIMS, however, said its treating team concluded in 2017 that corrective surgery was not feasible because of the complexity of her cardiac anatomy and advised medical management.

The hospital has now constituted a committee to review her complete clinical records, investigations, treatment, expert opinions and the circumstances surrounding her death. An autopsy is also underway.

What Is Pulmonary Atresia With VSD?

A VSD is a hole in the wall separating the heart’s two lower chambers. The right side of the heart pumps oxygen-poor blood towards the lungs through the pulmonary artery.

In pulmonary atresia, the normal route through which blood leaves the right side of the heart and reaches the lungs is blocked or has not developed properly.

This can severely block blood flow to the lungs and reduce the amount of oxygen entering the bloodstream.

When pulmonary atresia occurs along with VSD, doctors have to deal with multiple abnormalities rather than simply closing the hole.

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Treatment Is Complicated

Some children may initially require procedures to ensure adequate blood reaches the lungs. Doctors may use medicines temporarily and later create an alternative pathway for blood flow through a shunt.

In some patients, the pulmonary arteries remain very small and the body develops additional blood vessels supplying the lungs.

These vessels, called major aortopulmonary collateral arteries (MAPCAs), may need to be brought together through a procedure called unifocalisation.

A conduit may then be used to connect the heart to the lungs, while the VSD may also need to be closed.

The anatomy can also change as a child grows. Small pulmonary arteries, abnormal blood vessels and rising pressure in the lungs can make later surgical repair more challenging.

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Events Leading Upto The Teen's Unfortunate Death

According to AIIMS, Tanvi was admitted on August 24 after her condition deteriorated and was being evaluated for a possible heart-lung transplant.

On September 1, she developed severe cyanosis, and her oxygen saturation fell to around 48%. AIIMS said she subsequently suffered a hypoxic spell followed by cardiac arrest. Despite oxygen support and resuscitation, she could not be revived and was declared dead at 5:06 am.

“The Director, AIIMS, New Delhi has constituted a committee to examine the matter in detail, review the sequence of events and establish the facts,” the institute said.

The committee’s findings and autopsy report will be important in establishing what happened and whether any intervention could have altered the outcome.

A new US CDC study has warned of a threefold rise in identifications of Trichophyton indotineae, a skin fungus that causes ringworm and is resistant to standard treatment.

Between 2022 and 2025, T. indotineae was identified in 29 countries, with resistance to terbinafine, a commonly used antifungal medication. The first US case was reported in 2023.

Most cases are treated with terbinafine, either as a cream or a pill.

“Our results reveal a marked global increase in T. indotineae isolation,” the authors wrote in their paper, published in the CDC’s monthly journal, Emerging Infectious Diseases.

What Did The Study Find?

During the study period, 566 users from 54 countries submitted 1,657,334 spectra that led to the identification of fungal agents.

• 123,025 (7.7%) were identified as Trichophyton spp. by 316 users across 44 countries.
• 3,399 (0.2%) were identified as T. indotineae by 183 users across 29 countries.
• Europe accounted for the largest share of users (63.8%), followed by Asia (16.8%), Latin America (15.7%), North America (1.6%), Oceania (1.6%), and Africa (0.5%).
• Most T. indotineae spectra were identified in Europe — 3,040 (89.4%).
• T. indotineae was also identified in countries where no cases had previously been reported, including Bulgaria, Croatia, Colombia, Luxembourg, and Uruguay.

However, the research cannot tell us how many people globally are contracting T. indotineae; it only shows that laboratories are detecting it more often.

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What Is Ringworm?

Ringworm has nothing to do with worms. The misleading name refers to an infection caused by dermatophytes, fungi that thrive in warmth and moisture.

It can affect people of all ages and is highly contagious. Careful attention and immediate treatment are required to control the infection effectively.

Ringworm, also called tinea corporis, is a skin infection caused by fungal spores invading the dead outer layers of the skin. It typically presents as circular, red, scaly patches accompanied by itching or discomfort.

Signs And Symptoms

Symptoms of ringworm depend on where the infection develops:

• Skin: It usually begins as a red, scaly patch or bump.
• Scalp: It may start as small, pimple-like lesions that progress into scaly, patchy areas.
• Nails: The nails may become thickened, discolored, brittle, or crumbly.

How Is Ringworm Transmitted?

Ringworm is highly infectious and can be transmitted through:

• Direct skin-to-skin contact: Touching an infected person can transmit fungal spores.
• Indirect contact: Sharing towels, bedding, or clothes with an infected person can spread the infection.
• Animals to humans: Ringworm can be carried by pets, including cats and dogs, without showing symptoms.

How To Prevent Ringworm

Preventing ringworm is largely about maintaining good hygiene and avoiding contact with infected people or animals.

• Shower regularly, dry thoroughly, and change clothes daily.
• Do not share towels, combs, or bedding.
• Wear flip-flops or sandals in community showers, tanning rooms, locker rooms, and pool areas.
• Consult a veterinarian if your animal displays signs of ringworm.
• Prevent fungal growth by keeping moist areas such as the groin and feet dry.

When To Seek Medical Attention?

Left untreated, ringworm can spread across the body or penetrate further, potentially leading to complications such as secondary bacterial infections.

See a doctor if:

• Symptoms do not go away with treatment.
• The infection affects the scalp or nails.
• You feel very uncomfortable or the affected area is severely inflamed.