A new study has found that a combination of two drugs could enhance the immune system to treat one of the most common types of cancer in the world, bowel cancer. Also known as colorectal cancer, despite its widespread presence, the treatment options for this condition are limited. What the study specifically found was that this procedure could shrink the tumours caused by this condition by around 60%.

What Are The Drugs Involved

The trial involved the use of two immunotherapy drugs, botancilimab and balstilumab. It is a monoclonal antibody that works to stimulate the body's immune system to attack cancer. The study is a rather significant find, as it’s the first time that a consistent and durable response to immunotherapy has been reported in patients with solid MSS mCRC tumours.

The study was divided into several phases for more than 6 months. In the US trial, around around 101 patients with microsatile stable metastatic colorectal (MSS-mCRC) tumours showed a decrease . Around 61% of the patients experienced tumour shrinkage or stabilization after combined treatment with votancilumab and balstilumab. When it comes to downsides, diarrhea and fatigue were found to be the most common side effects or side effects of this drug.

These results are interesting and open to exploration. To date, immunotherapy has not been effective in patients with CNS-mCRC tumors. This study demonstrates the potential of the combination of botenlimab and balstilimab in the treatment of CNS mCRC, providing new hope for people diagnosed with colon cancer.

What Could This Mean For Bowel Cancer Treatment In The Future

The study is currently in the final stages of clinical trials, and the US Food and Drug Administration (FDA) hopes to quickly gain approval for its use because of the importance of this area that affects many people. The efficiency shown demonstrates the potential of botansilimab to contribute to broad antitumor immunity.

All in all, the combination of botensilimab and balstilimab represents a promising new direction in the treatment of colorectal cancer. This breakthrough could improve conditions for many patients worldwide and lights a new hope in the fight against this common disease. The results of this study show the effectiveness of immunotherapy in this field and how its potential to transform cancer treatment can only grow in the years to come.

During the hot days of the year, amid a severe heatwave, it is only natural to feel irritable and anxious. But according to psychologists, some simple household chores will not just give you a sense of calm but will also work like meditation. Experts have found that manual chores like clearing away clutter, sweeping, and mopping prevent the mind from wandering while giving a concrete sense of accomplishment. Psychologists say that the process of cleaning is meditative and calming.

Experts and Zen monks often say that before enlightenment, one must carry water and chop wood. And even after enlightenment, the same process must be repeated. Repetitive activities like these can regulate the nervous system, as these acts are structured, predictable, and give a sense of completion at the end.

How does mopping help?

Zen monks and psychologists recommend mopping the floor, as this activity gives a sense of grounding and control. Additionally, one can immediately see the results of one's work, which is more satisfying than cognitive and emotional tasks that have slow results. "Unsui" monks spend most of their time tidying and cleaning. In A Monk's Guide to a Clean House and Mind, a monk wrote that they sweep dust to remove worldly desires and scrub dirt to free themselves from attachment. This time spent cleaning everything carefully, they say, is extremely fulfilling.

The mental health benefits of cleaning

Psychologists say that people who dread cleaning or find it daunting can engage in the activity to improve focus rather than stress about a to-do list. People who see cleaning as drudgery often feel that the shift is less about forcing oneself to enjoy it than about changing the way one engages with the activity. But the key here is not to rush through the process — experts say that it is imperative to pay attention to the rhythm of the physical movement or to things like water temperature.

When slowed down, it helps one focus on the sensory aspects, and it can start to function like a mindfulness exercise. Cleaning is an opportunity to free the mind and care for oneself and the world. For monks, cleaning is not just about fixing a room; it is a way to expand oneself and nurture one's relationship with the world. Therefore, instead of looking for a perfect result, it is important to embrace incompletion without anxiety.

When one feels overwhelmed, it is not about the task but about what the task represents. This could be self-judgement, time pressure, or anxiety, for instance. Breaking a task down into small and defined actions can reduce barriers. Therefore, instead of getting engrossed in the activity, one must try to break the task down into smaller and defined actions that reduce barriers. Start by choosing one room or surface to clean. Start with baby steps and then ease into the process. This awareness will give you a sense of peace similar to what one finds in temples.

The Union Ministry of Health and Family Welfare today notified the inclusion of the drug “Pregabalin” under Schedule H1 of the Drugs Rules, 1945, to strictly regulate the painkiller amid rising concerns over its misuse and abuse, particularly among youth.

Pregabalin, sold under the brand names Axalid and Lyrica, is a prescription medication used to treat epilepsy, neuropathic (nerve) pain, fibromyalgia, and generalized anxiety disorder. It was earlier regulated under Schedule H.

The ministry noted that the drug has reportedly been misused for its sedative, euphoric, and dissociative effects. Authorities have reported seizures of illegally stocked and unauthorized sale of Pregabalin from parts of the country.

Thus, the move to add it to Schedule H1 aims to:

• Curb easy access
• Enhance prescription monitoring
• Strengthen supply chain accountability
• Safeguard public health

In a gazette notification, the ministry said Pregabalin can now be sold only after a registered medical practitioner’s prescription.

The revised classification mandates that:

• Retailers must maintain a separate register recording details of prescriptions and sales
• Manufacturers shall prominently display the prescribed “Schedule H1 Drug Warning” label on product packaging
• Violations and non-compliance will attract penal action under the Drugs and Cosmetics Act, 1940, and Rules thereunder

All stakeholders, including manufacturers, distributors, wholesalers, retailers, and pharmacists, are advised to ensure strict compliance with the provisions of the notification.

Also read: India Cracks Down On Injectable Cosmetic Procedures In Beauty Clinics

Can Pregabalin Cause Heart Failure?

A 2025 study led by researchers at Columbia University Irving Medical Center linked Pregabalin with a surprisingly large increase in the risk of heart failure among older patients with known heart disease.

The study found that Pregabalin was associated with a 48 per cent higher risk of developing heart failure.

For patients with an existing history of heart disease, the risk jumped to 85 per cent. In absolute terms, the researchers estimated around six additional cases of heart failure per 1,000 people taking Pregabalin each year, compared to those not on the drug.

What Should Patients Do?

Like all medicines, Pregabalin carries side effects. Common ones include headaches, nausea, diarrhoea, blurred vision, and memory issues. Rarely, it can trigger a life-threatening allergic reaction called anaphylaxis.

If you take Pregabalin, do not stop it suddenly. Stopping abruptly can cause withdrawal-like symptoms. Instead, book an appointment with your GP or specialist to discuss the risks and benefits in your specific case.

If you have a history of heart disease, a heart condition, or new symptoms such as increased breathlessness, persistent swelling, or faintness, mention them promptly.

Pregabalin helps many people with otherwise disabling nerve pain, but like any tool, it must be used with care and attention to context. For older adults and those with heart disease, a conversation with a clinician could be the difference between control and complication.

Earlier this week, the Central Drugs Standard Control Organisation tightened rules around cosmetic use, amid growing concerns that injectable aesthetic procedures are gaining popularity as “cosmetic” treatments in beauty clinics and wellness centers across the country.

In a new public notice issued this week, the CDSCO stated that cosmetic products that come in injectable form do not fall under the definition of cosmetics under the law. It said that such products are not permitted for use by consumers, professionals, or aesthetic clinics.

Microplastics and nanoplastics are now being spotted in water, packaged food, seafood, plastic containers, and even in the air we breathe. Over time, these tiny particles may slip into the digestive tract and interfere with gut health. While the research here is still unfolding, there is rising concern that long-term exposure could promote inflammation, disturb gut flora, and possibly lead to metabolic or digestive troubles.

Dr Vinod Gowda K H, Consultant, Medical Gastroenterology, Fortis Hospital, Yeshwantpur, Bengaluru, said, “The recent study claiming that probiotic bacteria might help bind with nanoplastics is pretty interesting because it points to how protective the gut microbiome could be. Probiotics are the helpful bacteria that support digestion, immunity, and an overall steady state in the gut. Some fermented foods naturally carry these good microbes, and researchers are now looking at whether they can also reduce the uptake or build-up of harmful particles inside the body.”

Also Read: Eli Lilly's Retatrutide Shows Record Weight Loss In Third Phase Of Trials

Fermented food in Indian cuisine

In India, fermented foods have been part of everyday traditional eating for ages. Things like curd, buttermilk, idli, dosa batter, kanji, and homemade pickles can support gut well-being, especially when they are made hygienically and eaten in moderation. When the gut microbiome is healthy, it may strengthen the body’s natural defenses and help lower inflammation.

Still, it is important to note that fermented foods are not really a direct fix or a sure-shot answer to microplastic exposure. More studies in humans are needed before any confident medical advice can be given. The smarter route is prevention—cutting down on plastic containers for hot food, reducing heavily processed packaged items, and maintaining a balanced diet that is high in fibre and mostly natural foods. This line of research feels hopeful because it brings fresh conversations about preventive healthcare, gut health, and how environmental pollution can actually affect the human body.

How do microplastics enter your body?

Dr Adarsh C K, HOD & Sr. Consultant—Medical Gastroenterology, Hepatology & Advanced Endoscopy, Gleneagles BGS Hospital, Kengeri, Bengaluru, said in an interview with Health and Me, “Plastic exposure has quietly become part of modern life. Tiny plastic particles are now being found in drinking water, packaged food, seafood, and even the air around us, which is why researchers are increasingly studying how the body responds to them over time. One area creating interest is the possible role of gut bacteria in limiting how much of these particles actually stay inside the body.”

A natural shield

Some early studies suggest that beneficial bacteria found in fermented foods may act like a kind of natural ‘shield’ inside the gut. Instead of breaking plastics down, these microbes appear to latch onto certain microplastics and nanoplastics, making it easier for the body to remove them through waste. Researchers in South Korea recently studied a bacterial strain taken from kimchi and found that it showed a surprisingly strong ability to interact with nanoplastics in laboratory conditions designed to mimic the human digestive system. Animal studies linked to the research also showed increased elimination of these particles after probiotic intake.

“From a medical standpoint, the findings are interesting because scientists are concerned about the long-term effects of nanoplastics on inflammation, gut health, hormones, and cellular stress. The digestive system is one of the first places where environmental toxins interact with the body, so maintaining a healthier gut environment could potentially play a protective role,” Dr Adarsh added.

Are fermented foods the cure?

At the same time, this should not be misunderstood as fermented foods being a cure for plastic exposure. The science is still developing, and human trials are limited. For now, the more practical takeaway is that supporting gut health through balanced eating, fibre-rich foods, and naturally fermented foods may strengthen the body’s resilience while we continue trying to reduce everyday exposure to plastics overall.