A new study has found that a combination of two drugs could enhance the immune system to treat one of the most common types of cancer in the world, bowel cancer. Also known as colorectal cancer, despite its widespread presence, the treatment options for this condition are limited. What the study specifically found was that this procedure could shrink the tumours caused by this condition by around 60%.

What Are The Drugs Involved

The trial involved the use of two immunotherapy drugs, botancilimab and balstilumab. It is a monoclonal antibody that works to stimulate the body's immune system to attack cancer. The study is a rather significant find, as it’s the first time that a consistent and durable response to immunotherapy has been reported in patients with solid MSS mCRC tumours.

The study was divided into several phases for more than 6 months. In the US trial, around around 101 patients with microsatile stable metastatic colorectal (MSS-mCRC) tumours showed a decrease . Around 61% of the patients experienced tumour shrinkage or stabilization after combined treatment with votancilumab and balstilumab. When it comes to downsides, diarrhea and fatigue were found to be the most common side effects or side effects of this drug.

These results are interesting and open to exploration. To date, immunotherapy has not been effective in patients with CNS-mCRC tumors. This study demonstrates the potential of the combination of botenlimab and balstilimab in the treatment of CNS mCRC, providing new hope for people diagnosed with colon cancer.

What Could This Mean For Bowel Cancer Treatment In The Future

The study is currently in the final stages of clinical trials, and the US Food and Drug Administration (FDA) hopes to quickly gain approval for its use because of the importance of this area that affects many people. The efficiency shown demonstrates the potential of botansilimab to contribute to broad antitumor immunity.

All in all, the combination of botensilimab and balstilimab represents a promising new direction in the treatment of colorectal cancer. This breakthrough could improve conditions for many patients worldwide and lights a new hope in the fight against this common disease. The results of this study show the effectiveness of immunotherapy in this field and how its potential to transform cancer treatment can only grow in the years to come.

Extreme frigid temperatures have led to the death of 18 people across New York, Mayor Zohran Mamdani has confirmed.

Since late January, the city has been gripped in a cold snap, including 13 days of temperatures of 0C (32F) or below, one of the longest stretches of sub-zero weather New York has seen in six decades since a major snowstorm.

According to Mamdani, certain days in New York have been colder than the continent of Antarctica.

"Since Friday's press conference, one additional New Yorker lost their life on the streets of our city as a result of this cold snap. The total lives lost is now 18. Each life lost is a tragedy, and we will continue to hold their families in our thoughts," he said.

He also urged those experiencing homelessness to head to a shelter one of the 1,400 placements that have been made into shelters and safe havens. Apart from this, 33 New Yorkers have also been involuntarily transported for their safety in these conditions.

"Until temperatures warm up, I ask all of you in this room and outside of it to please continue to take additional precautions. Stay safe, stay indoors, and please, New York, let's keep looking out for one another," the mayor said.

The newly minted Mayor also said that across this past Friday and Saturday nights, 560 New Yorkers used Health + Hospitals warming centers and nearly 300 New Yorkers used a Department of Social Services warming vehicle.

READ MORE: US Cardiologist Reveals When You Are More Prone To Heart Attacks

On 27 January, Mamdani noted that at least 10 of the people who had died were found outdoors. The cause behind the other deaths remain known.

"We have been working hard to keep New Yorkers safe, and we will continue to do so. Because it is not forecast to be above 32 degrees [Fahrenheit] until tomorrow, and 35 degrees is hardly balmy weather," he said.

Experts Recommend Drinking More Water During Winters

Winter is usually associated with hot drinks, cozy layers and fewer reminders to sip water. According to Dr. Swadesh Kumar, Cluster Head – Emergency and Trauma Care & Casualty, Gurugram, this mindset is exactly where the problem begins.

“People assume that because they’re not sweating or feeling thirsty, their body doesn’t need as much water. That’s a misconception,” he told Healthandme.

During cold spells, thirst signals are naturally suppressed. At the same time, the body continues to lose fluids through dry air, indoor heating and even breathing. “The loss is gradual and silent, which makes winter dehydration harder to spot,” Dr Kumar added.

Low fluid intake doesn’t just cause weakness, it can aggravate underlying health problems. When the body is dehydrated, blood becomes thicker, increasing the risk of clot formation. This is particularly dangerous for older adults and people with heart disease.

Kidneys are also affected. Reduced hydration puts extra strain on them, sometimes leading to acute kidney injury. “We see patients with palpitations, fainting spells and extreme weakness, only to later realize dehydration is the root cause,” Dr Kumar notes.

Winter illnesses further complicate the situation. Fever, rapid breathing and certain medications increase fluid loss. Yet many people intentionally avoid drinking water to reduce bathroom visits in the cold.

“This combination is especially risky for children and the elderly,” Dr. Kumar says. Children depend on caregivers for hydration reminders, while older adults naturally feel less thirsty. Both groups can slip into dehydration quickly during winter infections.

Simple Habits Can Prevent Serious Risk

Doctors advise treating hydration as a routine, not a response to thirst. Warm water, soups, stews and herbal drinks are practical winter options. Fruits with high water content also help, even when appetite is low.

“Monitor urine color, limit excess caffeine and be extra careful if you have a chronic condition,” Dr Kumar advises.

The cold wave is a reminder that dehydration isn’t just a summer problem. Even in winter, the body needs adequate water to function, and ignoring that need can quietly turn into a medical emergency.

People suffering from obesity are 70 percent more likely to be hospitalised or die from an infectious disease, including flu, COVID-19 and pneumonia, according to a Lancet journal study.

Researchers from the UK and Finland, who analyzed over 500,000 people, found that those with a BMI of 30 or higher were at a significantly higher risk compared with people with a healthy BMI between 18.5 and 24.9. The risk escalated as body weight increased.

Dr Solja Nyberg, of the University of Helsinki and the study's first author, noted the problem could worsen and said: “As obesity rates are expected to rise globally, so will the number of deaths and hospitalizations from infectious diseases linked to obesity.

“To reduce the risk of severe infections, as well as other health issues linked with obesity, there is an urgent need for policies that help people stay healthy and support weight-loss, such as access to affordable healthy food and opportunities for physical activity.”

In the meantime, she added, it was “especially important” for those living with obesity to keep up to date with their vaccinations.

According to the World Health Organisation, obesity has been linked to 3.7 million deaths globally in 2024. If strong action is not taken, the number of people living with obesity is expected to double by 2030. Recently, the WHO released its first-ever guideline on the use of Glucagon-Like Peptide-1, or GLP-1, therapies for managing obesity as a chronic and relapsing condition.

“Obesity is a major global health challenge that WHO is committed to addressing by supporting countries and people worldwide to control it effectively and equitably. Our new guidance recognises that obesity is a chronic disease that can be treated with comprehensive and lifelong care,” said WHO Director-General Dr Tedros Adhanom Ghebreyesus.

Is Global Obesity On The Rise?

While industrialized societies see soaring obesity rates, traditional and farming communities experience much lower levels of obesity, a contrast often attributed to more physically demanding lifestyles.

This is where this recent study plays a big role. The study found that this assumption does not fully hold true. Even though physical activity across population, or the energy expenditure, that is the total calories burned daily is not significantly lower in industrialized population, their body size is larger. So, if not the energy output, then what is the reason? The answer lies in the diet.

READ MORE: Diet, Not Lack Of Exercise Is The Real Reason For Rise In Obesity, According To Study

Childhood Obesity: The Silent Crisis

According to Mayo Clinic, doctors define it as having a body mass index (BMI) at or above the 95th percentile for children 2 years and older. In recent times, India has begun seeing a worrying rise in childhood obesity cases, especially in cities where lifestyle changes, unhealthy diets, and less physical activity are driving the trend.

In the United States, CDC data from 2017–2020 showed that about 19.7% of children and adolescents between ages 2 and 19 had obesity, roughly 14.7 million young people. Among them, 12.7% were between ages 2–5, 20.7% were 6–11, and 22.2% were 12–19.

Dr Vivek Jain, Senior Director & Unit Head, Paediatrics, Fortis Hospital explains that in recent years, obesity among children has risen sharply due to many factors. Kids are spending more time in front of screens, getting less outdoor play, and attending online classes, all of which cut down their activity levels. At the same time, fast food, sugary drinks, and packaged snacks have become a regular part of diets.

Modern lifestyles also encourage frequent dining out, reliance on processed meals, and irregular eating. Add limited access to safe play areas, heavy academic schedules, and family history of obesity, and the risks become even higher.

Without intervention, obesity in childhood often continues into adulthood, increasing chances of diabetes, high blood pressure, heart problems, and even some cancers.

How To Prevent Childhood Obesity

Prevention needs a joint effort from families, schools, communities, and policymakers. Parents play the most important role, as they shape habits from an early age. Dr. Vivek suggests:

• Balanced nutrition: Encourage home-cooked meals with fruits, vegetables, whole grains, and lean proteins. Limit fried foods, sugary drinks, and packaged snacks.
• Physical activity: Aim for at least 60 minutes of active play or exercise daily, such as sports, cycling, or outdoor games.
• Reduced screen time: Limit television, mobile, and gaming time to help children stay active and sleep better.
• Family involvement: Lead by example—eat meals together, exercise as a family, and make health a priority.
• School initiatives: Schools should provide nutritious meals, promote physical education, and teach healthy habits.

Chickenpox cases occur regularly in India, with outbreaks common, especially among children aged from one to nine years old. However, pediatricians across Pune are warning against the exponential rise in cases this winter.

Dr Shirish Kankariya, head of paediatrics at Apollo Hospital Swargate, said he had seen around 15 chickenpox patients in Jan alone, and the current season has brought a visible uptick in cases.

"Chickenpox cases have risen. We are also seeing infections in older children and adult family members, who never had the disease earlier," he told Times of India.

Dr Prateek Kataria, consultant pediatrician and neonatologist at Sahyadri Hospital also noted that out-patient departments (OPDs) have recently seen a large increase confirmed chickenpox cases this year.

He also told the publication: "We are seeing many children with chickenpox in the OPD even among those who have taken both doses of the vaccine. This is expected because the vaccine does not guarantee 100% protection, but vaccinated children usually develop milder illness and do not need hospitalization."

This comes months after reports emerged that cases were rising in Kerala's Kollam district. In October 2025, health authorities confirmed over 100 new cases, with numbers continuing to climb.

What Is Chickenpox And How Does It Spread?

Chickenpox, caused by the varicella-zoster virus, is extremely contagious and spreads through respiratory droplets or direct contact with someone who is infected. In children, it often starts as a mild rash accompanied by fever, but it can spread quickly in crowded areas.

The virus can also be transmitted through coughing or sneezing, and it is most infectious a day or two before the rash appears and in the early days of the rash. In individuals with weak immunity, the dormant virus may reactivate later in life, causing shingles (herpes zoster).

READ MORE: NHS Chickenpox Vaccine Explained: Eligibility Rules And Timeline For Children

How To Detect Chickenpox Symptoms Early?

How To Spot A Chickenpox Rash

The first rash usually shows up as small red bumps on the face, chest, or back. These bumps quickly turn into blisters filled with fluid, which are contagious. Over a few days, the blisters break and crust over, forming scabs. It’s common to see spots, blisters, and scabs all at the same time, according to the CDC.

Stages Of Chickenpox

The Mayo Clinic explains that chickenpox progresses in three main stages:

• Incubation Stage (10–21 days): After exposure, the virus remains inactive. Infected individuals typically show no symptoms during this period.
• Prodromal Stage (1–2 days): Early signs include fever, tiredness, headache, loss of appetite, and body aches. This is also when the virus can start spreading to others.
• Rash Stage (5–10 days): Red, itchy spots appear first on the face and chest, spreading across the body. These spots develop into fluid-filled blisters that scab over within a few days. Mild fever, itching, and discomfort are common during this stage.

According to the Cleveland Clinic, complications are uncommon but can include pneumonia, brain inflammation (encephalitis), and bacterial skin infections. Vulnerable groups, such as infants, pregnant women, older adults, and people with weakened immunity are at higher risk of severe illness.