Singer Jesy Nelson recently shared an emotional update regarding the complications she is experiencing in her pregnancy with twin babies. Former Little Mix singer Jesy, who is having twins with partner Zion Foster, announced that she has been diagnosed with pre-twin-to-twin transfusion syndrome (pre-TTTS). The condition, which is present in pregnancies involving twins with a shared placenta, has serious risks involved and needs intense medical supervision. As Nelson embarks on this difficult journey, her story enlightens us about a rare but dangerous condition many expectant parents may not know much about.

Twin-to-twin transfusion syndrome is a rare but dangerous condition that arises in monochorionic twin pregnancies, in which identical twins share a single placenta. The placenta supplies the developing babies with oxygen, nutrients, and blood flow, but in TTTS, there is an imbalance of blood vessels that interconnect the twins, and thus the vital resources are not evenly distributed. One twin, or the donor twin, shares excess blood with the other, referred to as the recipient twin. This leads to one baby becoming malnourished and possibly anemic, and the other in danger of heart problems due to too much blood.

Nelson described her diagnosis in a heartfelt Instagram video, explaining that she is currently in the pre-stage of TTTS and undergoing frequent monitoring. "I am being scanned twice a week, and each time, things have gotten a little worse," she shared, expressing her fears and hopes for the health of her babies.

Potential Risks of TTTS

If left untreated, TTTS can have devastating consequences. Medical research indicates that:

• 90% of the cases of untreated TTTS lead to loss of one or both twins.
• Despite treatment, only a 70% survival rate for both twins is assured.
• Severe forms can result in preterm labor, cardiac failure in the recipient twin, and organ failure in the donor twin.
• Complications in long-term survivors include neurological damage and developmental delay in surviving infants.

TTTS usually advances in stages, beginning with minimal changes in fluid levels and worsening as one twin continues to get an unequal share of blood. In extreme cases, fetal laser surgery, referred to as the Solomon technique, can be employed to divide the blood vessels and balance the twins.

Why Identical Twin Pregnancies Are More Complicated

Identical twins may develop differently, and their own unique form of placental sharing can have a dramatic effect on pregnancy risk. Jesy Nelson's twins are considered monochorionic diamniotic (mono/di), which means they share a placenta but have two amniotic sacs. This is the type of pregnancy in about 70% of identical twin pregnancies and carries an increased risk of complications like TTTS, umbilical cord entanglement, and growth restriction.

Conversely, dichorionic diamniotic (di/di) twins both have a separate placenta and amniotic sac, which greatly diminishes the threat of TTTS. Twin pregnancy type is normally identified by early ultrasound, with physicians being able to track future complications from inception.

Other Twin Pregnancy Health Risks

Twin pregnancies, even without the presence of TTTS, entail a variety of health risks to the mother as well as infants:

1. Premature Birth

Over 60% of twin pregnancies end in premature delivery, with birth usually taking place before 37 weeks. Premature infants can have immature organs and need neonatal intensive care (NICU) assistance to assist with breathing, feeding, and infection fighting.

2. Gestational Hypertension and Preeclampsia

Pregnant women with multiples are at increased risk of having high blood pressure during pregnancy. This, if left untreated, can result in preeclampsia, a serious complication of pregnancy that can result in damage to organs, preterm labor, and in some cases, maternal or fetal death.

3. Anemia

Pregnant women carrying multiples are twice as likely to experience anemia, a condition where the body does not produce enough healthy red blood cells. This can lead to fatigue, dizziness, and complications during delivery.

4. Birth Defects

According to John Hopkins Medicine, multiple birth babies are twice as likely to have congenital abnormalities compared to single births. These can include heart defects, neural tube defects, and gastrointestinal issues.

5. Amniotic Fluid Imbalances

When twins have to share a placenta, they are more likely to have polyhydramnios (excess amniotic fluid) or oligohydramnios (not enough amniotic fluid). Both result in distress to the babies during fetal development and can result in premature labor.

6. Postpartum Hemorrhage

Twins are at increased risk of excessive postpartum hemorrhage because their uterus is larger and there are greater blood supply needs.

Jesy Nelson's openness about her challenging experience is raising awareness for TTTS, a condition that few individuals—let alone expectant mothers and fathers—might be aware of. Through her tearful video, Nelson stressed the significance of knowing about twin pregnancies aside from the thrill of having multiples. "We had no idea that this type of thing occurs when you're having twins. We just desperately want to make people aware of this because there are so many people who aren't aware."

Her case reminds us of the intricacies involved in twin pregnancy and the significance of early identification and medical management. For mothers carrying twins, frequent ultrasounds and vigilance can become a life-and-death issue for early detection and better outcomes of both babies.

Through constant medical attention and care, she and her partner Zion Foster remain positive and get ready for their babies to be born. In other parents whose situations are no different, the story of Nelson highlights awareness, medical progress, and emotional encouragement in handling complicated pregnancies.

The expecting parents of twin siblings are advised to discuss TTTS screening and possible interventions with their physicians to give their babies the best chance.

Two experimental heart drugs developed by Novartis and Novo Nordisk have failed to reduce major cardiovascular events in separate late-stage trials, despite successfully targeting cholesterol and inflammation.

Novartis' pelacarsen lowered lipoprotein(a), or Lp(a), by 78%, while Novo Nordisk's ziltivekimab substantially reduced inflammatory markers. However, neither drug reduced heart attacks, strokes or cardiovascular deaths compared with a placebo.

"Everybody in the world, me included, thought that this was going to work," said Dr. Steven Nissen of Cleveland Clinic, presenting the pelacarsen results at the American Heart Association's Scientific Sessions 2026.

Novartis' Pelacarsen Fails To Reduce Heart Events

Also read: Confused By Your Cholesterol Report? Here's What LDL And ApoB Really Mean

The seven-year Phase III Lp(a) HORIZON trial involved 8,323 people with established cardiovascular disease and elevated Lp(a) levels across 42 countries.

Participants received monthly injections of pelacarsen or a placebo. Despite reducing Lp(a) by 78%, the drug did not lower the risk of non-fatal heart attacks, strokes, urgent procedures to unblock arteries or cardiovascular deaths.

Even participants with higher Lp(a) levels showed no cardiovascular benefit.

"I cannot avoid the disappointing conclusion – it didn’t work," Nissen said, adding that cardiovascular outcomes remained unchanged despite the significant reduction in Lp(a).

Novo Nordisk's Ziltivekimab Also Fails

Novo Nordisk's Phase III ZEUS trial tested whether ziltivekimab, an experimental anti-inflammatory drug, could reduce cardiovascular events by blocking interleukin-6 (IL-6).

The trial included 6,376 patients with atherosclerotic cardiovascular disease, chronic kidney disease and systemic inflammation.

In July 2026, Novo announced that the trial had failed to demonstrate a cardiovascular benefit. Results published in the New England Journal of Medicine on November 7 showed that although the drug substantially reduced inflammatory markers, it did not prevent major cardiovascular events.

During a median follow-up of 33 months, cardiovascular death, non-fatal heart attack or non-fatal stroke occurred in 17.6% of patients receiving ziltivekimab and 17.7% receiving placebo.

On September 7, Novo Nordisk discontinued two additional late-stage trials of ziltivekimab in patients with heart failure and inflammation.

An independent data monitoring committee recommended stopping the studies, concluding they were unlikely to succeed.

Read More: This Common Heart Attack Risk Starts Silently In Healthy People In Their 20s

Why Did The Drugs Fail?

Nissen suggested that participants may have had advanced cardiovascular disease, making it too late for the drug to prevent further events.

Dr. Roger Blumenthal of Johns Hopkins suggested that participants' blood pressure and LDL cholesterol were already well controlled, leaving limited scope for additional risk reduction.

Another hypothesis was that anti-clotting medications taken by all participants may have diluted pelacarsen's potential effect, since Lp(a) is thought to contribute to cardiovascular disease partly by promoting blood clots.

These remain hypotheses, not proven explanations.

The findings also do not mean that Lp(a) or inflammation is irrelevant to heart disease. They show that lowering these markers with these particular drugs did not reduce cardiovascular events in the populations studied.

What Happens Next?

People with elevated Lp(a) can manage their cardiovascular risk by addressing other risk factors.

Nissen recommended exercise, weight management and lowering LDL cholesterol with statins when appropriate.

Three other cardiovascular outcome trials involving investigational Lp(a)-lowering drugs are underway. Their results may help determine whether targeting this cholesterol particle can prevent heart attacks and strokes.

Climate change is no longer a distant environmental concern. The effects of increasing temperatures, extreme weather events, melting glaciers, changing rainfall patterns and worsening air pollution on human health are alarming. Countries are continually identifying these health risks but monitoring if their climate policies are actually effective is the big question. This is one of the important areas of discussion at the 31st United Nations Climate Change Conference (COP31), which starts on November 9, 2026 in Antalya, Türkiye.

The World Health Organization (WHO) is stressing upon health to become a central part of climate policy discussions. The health body has urged countries to increase focus on measurable action, healthcare systems that can withstand climate change and funding to execute those actions.

Ahead of the conference, Dr Diarmid Campbell Lendrum, Head of the Climate Change, Energy, and Air Quality Unit at WHO headquarters said, “Health is the strongest argument for climate action."

Countries Need Reliable Health Indicators For Climate Change

Also read: Climate Crisis Is A Health Crisis: Just 6 Actions Could Save 1.6 Million Lives, Says WHO

Climate change has numerous effects on health. Extreme heat can lead to dehydration, heat exhaustion and heatstroke, while floods and droughts can disrupt access to safe drinking water, food and healthcare. Changing temperatures and rainfall patterns can also fuel spread of infectious diseases, including mosquito-borne illnesses.

Air pollution, which is closely linked to the burning of fossil fuels, adds to the burden of respiratory and cardiovascular disease.

However, measuring these effects is not as straightforward as one might think.

An increase in hospital admissions during a heatwave, for instance, could be considered an indicator, but countries also need to monitor who is most affected, whether healthcare facilities can cope and whether preventive measures are working.

A WHO review published in October 2025, Mapping Climate Change and Health Indicators, examined 31 reports from 22 countries. It identified 3,880 indicators being used to assess health risks related to climate change. After removing overlaps and combining similar measures, researchers identified 1,684 unique indicators.

These indicators covered climate hazards, population exposure, vulnerability, health outcomes, the impact on healthcare systems, future risks, and the policies and resources available to address them.

What Will Countries Measure?

Also read: Big Lancet Report: Heat-Related Deaths Rise 36% Since Paris Climate Agreement, Global Warming Blamed

Health indicators can help governments think beyond recording extreme weather events and examine their consequences for public health and healthcare systems. Some of the areas that countries could monitor include:

• Heat-related illness and deaths: Hospital admissions, emergency visits and mortality linked to extreme temperatures.
• Infectious diseases: Changes in the geographical spread of climate-related diseases, including dengue and malaria.
• Food and water security: Malnutrition, food insecurity and illnesses linked with unsafe drinking water.
• Healthcare infrastructure: The number of hospitals vulnerable to floods, heatwaves and other extreme weather events.
• Healthcare preparedness: Availability of early warning systems, emergency response plans, trained health workers and essential emergency medicines.
• Population vulnerability: Health impacts on children, older adults, people with disabilities, outdoor workers and underprivileged communities.

What Is WHO Calling For At COP31?

WHO is using COP31 to push for stronger implementation of existing climate and health commitments. Its priorities include making healthcare systems resilient to climate change, reducing the health sector's environmental footprint and ensuring that health considerations are included in climate policies and financing decisions.

The conference will begin with a dedicated Health Day on November 9, featuring discussions on health technologies related to climate, digital health, humanitarian response and resilient healthcare systems.

WHO's November 2026 briefing estimates that 3.3 to 3.6 billion people live in contexts highly vulnerable to climate change. It also says that scaling up six climate health actions could save 1.6 million lives annually and generate around US$24 in returns for every dollar invested.

Ultimately the challenge for countries is to turn climate and health commitments into measurable improvements. Tracking heat-related deaths, diseases, healthcare preparedness and unequal health impacts can help governments understand where action is working and where gaps remain.

A wearable device developed by Zomato founder Deepinder Goyal has sparked a massive social media debate among doctors over its scientific claims and validity.

Called Temple, the gadget, worn on the forehead, is designed to track physiological signals linked with blood flow in the brain and generate a metric called 'Entropy', which, according to Goyal, is a measure of the body's real-time energy expenditure.

Also Read: Delhi AQI Crosses 2,000 Mark After Diwali: What Happens To Your Body Within Hours Of Exposure?

Priced at Rs 85,000, one of the factors that has sparked arguments, the device is now available pre-orders in India. However, medical experts have questioned whether the technology can accurately measure what it claims to and whether its readings offer meaningful insights into brain health, ageing or longevity.

The controversy intensified after Goyal defended the project against criticism from doctors. In a post on X, he said the development had cost $30 million, including $20 million of his personal money. He also said further research was underway.

“We have a number of new research breakthroughs coming up (especially Entropy), and are validating them as we speak,” Goyal wrote on November 6.

Can Temple Actually Measure Blood Flow To The Brain?

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One of the main concerns is the device's sensor placement. Temple uses optical sensors based on photoplethysmography (PPG), positioned near the temple. These detect changes in blood flow through superficial blood vessels.

However, the superficial temporal artery supplies blood to the scalp and face. The brain receives its blood supply primarily through the internal carotid and vertebral arteries. A signal detected from a superficial vessel cannot automatically be interpreted as a measurement of blood circulation inside the brain.

Dr. Cyriac Abby Philips, widely known online as The Liver Doc, is one of the many doctors who challenged Goyal's claims about Temple on social media post.

He wrote, "Deepinder's Temple device is very much like Baba Ramdev's Coronil. Only one difference. Former is scienceploitation, latter is pseudoscience and both are harmful in their own ways. Learn to identify a scam and fraud when you see one."

Dr Jason Philip, in an X post, called the research behind the device "pseudoscience". He said that the gravity ageing hypothesis is a flawed concept. Ageing is a result of many factors like metabolic factors, genomic instability, mitochondrial dysfunction, chronic inflammation and more.

Many also slammed Goyal for selling the device without solid research or clinical outcomes.

Dr Rishabh Jain responded to Goyal's post, saying that doctors asking for scientific evidence is a legitimate demand. He also said that Goyal's response to clinical questions are mostly commerce-based and does not "constitute scientific validation".

Dr Kapil Singhal, Director of Neurology at the Institute of Neurosciences, Medanta, Noida, told Mint, “Temple appears to be measuring blood flow in the superficial temporal artery, which supplies blood to the scalp, not the brain. The brain receives blood through the internal carotid and vertebral arteries. These are not the same.”

Dr Praveen Gupta, Chairman of Marengo Asia International Institute of Neuro & Spine, Gurugram, also cautioned against treating a reading from one location as representative of the entire brain.

A device may detect physiological changes near the forehead but establishing that these reflect cerebral blood flow requires comparison with established clinical measurements and independent validation.

What Is Entropy And Why Are Doctors Questioning It?

Also read: Mental Health And Longevity: The Mind-Body Connection To Aging Gracefully

Goyal has described Entropy as a new biomarker that measures how hard the body is working to sustain itself. The score is influenced by factors like sleep, exercise, stress, food and meditation.

However, doctors say that a metric responding to changes in activity does not establish what biological function it measures.

Neurologist Dr Sudhir Kumar told India Today that the idea was interesting but required stronger evidence.

“The idea of developing a novel physiological metric from signals recorded over the temple region is certainly intriguing, and advances in wearable technology have the potential to improve our understanding of human physiology. However, extraordinary claims require extraordinary evidence,” he said.

He added, “The key questions are not whether the signal changes with exercise, stress, or meditation, but whether it reliably measures what it claims to measure, whether it adds information beyond existing metrics, and whether acting on it improves health outcomes.”

In other words, doctors want to know how Entropy is calculated, what it represents biologically and whether it has been independently shown to improve health outcomes.

Gravity Ageing Hypothesis

Temple is also associated with Goyal's Gravity Ageing Hypothesis which proposes that gravity and prolonged periods spent upright may affect blood circulation to the brain and contribute to ageing.

However, the brain has a mechanism called cerebral autoregulation that helps maintain relatively stable blood flow despite changes in posture and blood pressure.

Dr Gupta told The Indian Express, “The brain automatically adjusts the size of its blood vessels and regulates blood supply to ensure that it continues to receive enough oxygen and nutrients, even when we change positions, stand up or exercise.”

He added that there is no established scientific evidence that everyday exposure to gravity progressively damages the brain or accelerates ageing.

More About Temple

Goyal has said that Temple is a wellness and research product rather than a medical device. He has also argued that its claims will be independently verifiable and that more research will be shared soon.

However, doctors say the difference between detecting a physiological signal and demonstrating its clinical significance is crucial. Temple's ability to track certain readings would not, by itself, establish that it can diagnose neurological conditions, predict cognitive decline or measure longevity.