Singer Jesy Nelson recently shared an emotional update regarding the complications she is experiencing in her pregnancy with twin babies. Former Little Mix singer Jesy, who is having twins with partner Zion Foster, announced that she has been diagnosed with pre-twin-to-twin transfusion syndrome (pre-TTTS). The condition, which is present in pregnancies involving twins with a shared placenta, has serious risks involved and needs intense medical supervision. As Nelson embarks on this difficult journey, her story enlightens us about a rare but dangerous condition many expectant parents may not know much about.

Twin-to-twin transfusion syndrome is a rare but dangerous condition that arises in monochorionic twin pregnancies, in which identical twins share a single placenta. The placenta supplies the developing babies with oxygen, nutrients, and blood flow, but in TTTS, there is an imbalance of blood vessels that interconnect the twins, and thus the vital resources are not evenly distributed. One twin, or the donor twin, shares excess blood with the other, referred to as the recipient twin. This leads to one baby becoming malnourished and possibly anemic, and the other in danger of heart problems due to too much blood.

Nelson described her diagnosis in a heartfelt Instagram video, explaining that she is currently in the pre-stage of TTTS and undergoing frequent monitoring. "I am being scanned twice a week, and each time, things have gotten a little worse," she shared, expressing her fears and hopes for the health of her babies.

Potential Risks of TTTS

If left untreated, TTTS can have devastating consequences. Medical research indicates that:

• 90% of the cases of untreated TTTS lead to loss of one or both twins.
• Despite treatment, only a 70% survival rate for both twins is assured.
• Severe forms can result in preterm labor, cardiac failure in the recipient twin, and organ failure in the donor twin.
• Complications in long-term survivors include neurological damage and developmental delay in surviving infants.

TTTS usually advances in stages, beginning with minimal changes in fluid levels and worsening as one twin continues to get an unequal share of blood. In extreme cases, fetal laser surgery, referred to as the Solomon technique, can be employed to divide the blood vessels and balance the twins.

Why Identical Twin Pregnancies Are More Complicated

Identical twins may develop differently, and their own unique form of placental sharing can have a dramatic effect on pregnancy risk. Jesy Nelson's twins are considered monochorionic diamniotic (mono/di), which means they share a placenta but have two amniotic sacs. This is the type of pregnancy in about 70% of identical twin pregnancies and carries an increased risk of complications like TTTS, umbilical cord entanglement, and growth restriction.

Conversely, dichorionic diamniotic (di/di) twins both have a separate placenta and amniotic sac, which greatly diminishes the threat of TTTS. Twin pregnancy type is normally identified by early ultrasound, with physicians being able to track future complications from inception.

Other Twin Pregnancy Health Risks

Twin pregnancies, even without the presence of TTTS, entail a variety of health risks to the mother as well as infants:

1. Premature Birth

Over 60% of twin pregnancies end in premature delivery, with birth usually taking place before 37 weeks. Premature infants can have immature organs and need neonatal intensive care (NICU) assistance to assist with breathing, feeding, and infection fighting.

2. Gestational Hypertension and Preeclampsia

Pregnant women with multiples are at increased risk of having high blood pressure during pregnancy. This, if left untreated, can result in preeclampsia, a serious complication of pregnancy that can result in damage to organs, preterm labor, and in some cases, maternal or fetal death.

3. Anemia

Pregnant women carrying multiples are twice as likely to experience anemia, a condition where the body does not produce enough healthy red blood cells. This can lead to fatigue, dizziness, and complications during delivery.

4. Birth Defects

According to John Hopkins Medicine, multiple birth babies are twice as likely to have congenital abnormalities compared to single births. These can include heart defects, neural tube defects, and gastrointestinal issues.

5. Amniotic Fluid Imbalances

When twins have to share a placenta, they are more likely to have polyhydramnios (excess amniotic fluid) or oligohydramnios (not enough amniotic fluid). Both result in distress to the babies during fetal development and can result in premature labor.

6. Postpartum Hemorrhage

Twins are at increased risk of excessive postpartum hemorrhage because their uterus is larger and there are greater blood supply needs.

Jesy Nelson's openness about her challenging experience is raising awareness for TTTS, a condition that few individuals—let alone expectant mothers and fathers—might be aware of. Through her tearful video, Nelson stressed the significance of knowing about twin pregnancies aside from the thrill of having multiples. "We had no idea that this type of thing occurs when you're having twins. We just desperately want to make people aware of this because there are so many people who aren't aware."

Her case reminds us of the intricacies involved in twin pregnancy and the significance of early identification and medical management. For mothers carrying twins, frequent ultrasounds and vigilance can become a life-and-death issue for early detection and better outcomes of both babies.

Through constant medical attention and care, she and her partner Zion Foster remain positive and get ready for their babies to be born. In other parents whose situations are no different, the story of Nelson highlights awareness, medical progress, and emotional encouragement in handling complicated pregnancies.

The expecting parents of twin siblings are advised to discuss TTTS screening and possible interventions with their physicians to give their babies the best chance.

Researchers in the Netherlands are exploring a possibility to reach into remote, difficult areas in the brain without an open surgery. They have developed a tiny, screw-shaped robot that can move through brain tissue under the control of a magnet placed outside the body.

The method is yet to be tested on humans. They used sheep brain tissue, including a model in which blood was pumped through the brain's vessels to more closely mimic a living brain.

In laboratory experiments, the robot successfully travelled through real sheep brain tissue, offering an early glimpse of a less invasive way to reach areas that are difficult to access with conventional surgery.

The technology could eventually be useful to treat deep brain tumours, blood clots following stroke and vascular abnormalities.

How Does The Tiny Robot Work?

Scientists have made the robot in a spiral, screw-like shape. It does not have a conventional motor inside it. Instead, researchers control it using a rotating magnetic field generated outside the body. As the magnet rotates, the robot moves with it. Its screw-shaped body converts that rotation into forward movement, allowing it to drill its way through soft brain tissue.

The researchers also created a mathematical model to predict when the robot could lose synchronisation with the magnetic field. Simply making the magnet spin faster does not mean the robot will keep moving faster.

“Push a magnetic robot too fast and it simply stops listening to the magnet,” said Ewout Ligtenberg, first author of the study. He added, “We can now predict exactly when that happens, for any tissue, from a single test. That takes out a lot of guesswork when designing robots for the brain.”

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Navigating Inside A Brain Is Not Easy

One of the biggest challenges of brain surgery is that is that brain tissue is soft, delicate and mechanically complex. The researchers initially tested their robot in gelatin before moving to actual sheep brain tissue.

In the sheep tissue, the robot remained synchronised with the magnetic field up to about 1.8 rotations per second when there was no blood flow. But once blood was pumped through the vessels, it fell to below 0.45 rotations per second. In other words, making the conditions that resemble a living brain made the robot harder to control.

The robot moved through the brain tissue at around 0.2 millimetres per second. When researchers reversed it, it was able to travel back through the pathway it had already created much faster, at about 2.9 millimetres per second.

Also read: New AI Tool Reads ECG In 2 Seconds, Detects Up To 90% Of Heart Valve Disease Cases

This May Help With Brain Lesions

The technology may have applications in treating brain lesions as some lesions sit deep inside the brain, where reaching them can mean passing through healthy tissue or opening the skull.

The researchers are look for a futuristic approach in which the tiny robot could potentially be guided through blood vessels to a location near the target, pass through the artery wall and then travel through brain tissue towards the lesion.

The robot has not been used to treat a brain tumour, remove a clot or operate on a person. Despite promising outcome, there are still major questions around safety, navigation, bleeding, tissue damage.

India has the medical expertise and infrastructure to perform significantly more corneal transplants, but a shortage of suitable donor corneas continues to leave thousands of patients waiting for treatment.

While an estimated 1 lakh corneal transplants are needed annually, only 25,000–30,000 are performed, meeting just 25–30% of the estimated need, said health experts as part of the 41st National Eye Donation Fortnight.

The shortage is also reflected in the availability of suitable donor tissue. In 2023–24, more than 49,000 corneas were retrieved in India, but only around 27,394 were considered suitable for transplantation.

Why Corneal Transplants Matter

Corneal blindness is a significant cause of treatable vision loss in India. “There is too much burden of corneal blindness in India, which is a leading cause of treatable blindness. Almost 1.1 to 1.3 million people are affected because of this corneal blindness,” said Dr Anita Gangar, Consultant Corneal Transplant Surgeon, Eye Department, Sir Ganga Ram Hospital, in a video posted on X.

The cornea is the transparent front surface of the eye that allows light to enter. When it becomes damaged, scarred or opaque, vision can be severely affected.

A corneal transplant replaces the damaged cornea with clear donor tissue, helping restore the eye’s optical pathway and vision.

Also read: World’s First Live AI-Assisted Brain Surgery Saves Patient’s Sight: How Does The Technology Work?

Common Causes of Corneal Blindness

• Corneal infections
• Eye trauma
• Surgery-related complications
• Hereditary conditions

Why Timely Eye Donation Matters

The availability of donor tissue remains a major constraint despite advances in corneal surgery.

“Corneal blindness is among the significant causes of vision loss that can potentially be treated through transplantation, yet thousands of patients continue to face a long and uncertain wait for suitable donor tissue,” said Padma Shri Prof. Dr Jeevan Titiyal, Regional Head – Clinical Services, Dr Agarwals Eye Hospital, at a press conference held in New Delhi.

The experts added that increasing eye donation requires not only greater public awareness but also stronger retrieval systems, efficient eye-bank networks and better coordination between hospitals and eye banks.

Timely retrieval is particularly important for preserving donor corneal tissue. Families are encouraged to contact an eye bank as soon as possible after the death of a loved one, with retrieval generally targeted within approximately six hours under appropriate conditions.

Read More: Diabetics Must Undergo Retinal Screening To Protect Eye Health: AIIMS Doctors

Eye Donation: Myths vs Facts

Myth: Diabetes or high blood pressure prevents eye donation.

Fact: These conditions do not automatically rule out donation. The medical team assesses tissue suitability after death.

Myth: Eye donation will disfigure the face.

Fact: Corneal retrieval is performed respectfully by trained professionals and does not cause visible facial disfigurement.

Myth: People who wear spectacles cannot donate their eyes.

Fact: Wearing spectacles or contact lenses does not automatically prevent donation. Eligibility is determined after death.

Myth: Only young people can donate.

Fact: People of different ages may be eligible, depending on the suitability of the donated tissue.

Advances in Corneal Transplantation

Corneal transplantation has evolved from conventional full-thickness procedures to more selective, layer-specific techniques. In suitable cases, surgeons can replace only the affected portion of the cornea, allowing for more targeted treatment and faster visual rehabilitation.

“Advances in corneal surgery now allow us to treat specific layers of the cornea, offering more targeted treatment and faster visual rehabilitation for appropriately selected patients. However, these advances can translate into better outcomes only when suitable donor tissue is available,” said Dr Prabjot Kaur, Senior Consultant Ophthalmologist, Dr Agarwals Eye Hospital.

41st National Eye Donation Fortnight

The 41st National Eye Donation Fortnight is being observed from 25 August to 8 September 2026. The 15-day nationwide awareness campaign, observed in India since 1985, aims to encourage eye donation and help bridge the gap between the demand for and availability of donor corneas.

Triple-negative breast cancer is notorious as it can respond to chemotherapy initially, only for some cancer cells to adapt, survive and eventually become resistant to treatment. Researchers at the Medical University of South Carolina’s Hollings Cancer Center may have found a way to turn that against the tumour's nature.

In a new study published in Cell Reports Medicine, scientists used a two-step drug strategy that first weakened drug-resistant cancer cells and then blocked the backup system they turned to for survival.

Marking a breakthrough, the combination significantly slowed tumour growth in several models of triple-negative breast cancer, including the ones made from patients whose tumours had stopped responding to chemotherapy treatment.

An important thing to note is that this is still laboratory and preclinical research and not a treatment that is readily available to patients.

How Does The Two-Step Drug Strategy Work?

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First Step:

The researchers mainly focused on a protein called lysyl oxidase, or LOX. LOX has always been studied for its role outside cancer cells, where it can make it easier for cancer to spread by altering the tissue around the tumour.

But the research team found that LOX has another job inside triple-negative breast cancer cells. It helps them produce energy, maintain healthy mitochondria and cope with cellular stress. Blocking LOX therefore cancer cells from spreading.

Burge Ulukan, PhD, a postdoctoral fellow and co-first author of the study, “LOX helps cancer cells keep multiple survival systems running. When we blocked LOX, the cancer cells lost that advantage." He added, “When we inhibit it, we are inhibiting multiple arms. We're disrupting cells' energy production and making them much more vulnerable to treatment.”

But the researchers observed that the instead of simply dying, the cancer cells adapted again after LOX was blocked.

Second Step:

Also read:

The next step in the strategy is blocking the cancer's backup route. Once LOX was blocked, the cancer cells became increasingly dependent on another protein called DHODH, which gave the scientists with an even better second target.

They paired an experimental drug used to block LOX with leflunomide, an FDA-approved drug that blocks DHODH. Together, the drugs pushed the cancer cells towards ferroptosis, a form of cell death caused by damaging molecules building up inside the cell.

The combination significantly blocked tumour growth across several models and performed better than the LOX inhibitor combined with standard chemotherapy. The researchers reported no major weight loss or signs of kidney or liver toxicity in the models tested.

Ozgur Sahin, PhD, co-leader of the Hollings Cancer Biology and Immunology Research Program, described the strategy as, “It's a one-two-punch approach. First, we block LOX, which weakens the cancer cells. As they adapt and become dependent on a backup survival pathway, we deliver the second punch by blocking that pathway, too.”

Why Triple-Negative Breast Cancers Are Challenging To Treat?

Triple-negative breast cancer gets its name as its cells lack three common treatment targets: oestrogen receptors, progesterone receptors and HER2. This leaves doctors with fewer targeted treatment options than they have for some other breast cancers.

Chemotherapy remains an important treatment, but resistance can develop quickly. Sahin said, “Triple-negative breast cancer is one of the most aggressive, deadliest versions of breast cancer. Chemotherapy is really the mainstay, and interestingly, this subtype is sensitive to chemotherapy compared to others, but resistance develops quite quickly.”

Till now, the findings have been demonstrated in labs and preclinical models. The researchers are now developing a newer version of their drug to trap LOX to prepare for human testing.