Experiencing daytime sleepiness is something that is usually perceived as a minor inconvenience, but for older adults, it could be an early warning sign of Dementia. This neurodegenerative disease leads to the progressive decline of brain cells. This eventually

affects memory, cognition, and personality, making everyday tasks more difficult. As one of the fastest-growing neurological disorders across the world, dementia poses a significant health threat to ageing populations.

Is Dementia Linked To Poor Sleep?

For this study, researchers followed 445 older adults (average age 76) over three years, aiming to determine whether poor sleep could increase the risk of mild cognitive impairment (MCI), which often leads to dementia. At the start, none of the participants had MCI, but by the end of the study, 36 individuals had developed the condition.

The researchers discovered that participants with poor sleep were more likely to develop MCI compared to those who slept well. However, when depression symptoms were taken into account, the link between poor sleep and MCI became less pronounced, suggesting that while sleep issues are a concern, mental health also plays a key role in dementia risk.

To assess sleep quality, the Pittsburgh Sleep Quality Index (PSQI) was used, evaluating factors such as sleep duration, disturbances, and daytime alertness. Among these, "daytime dysfunction"—defined as excessive sleepiness and low energy during the day—was most strongly associated with an increased risk of MCI. Those experiencing daytime dysfunction were more than three times as likely to develop MCI as those who didn’t report such symptoms.

There are many types of dementia:

Dementia is not a specific disease. According to the Centers for Disease Control and Prevention (CDC), it is an overall term that describes a decline in mental ability that interferes with daily life. People with dementia often have symptoms like trouble remembering, thinking, or making everyday decisions. These symptoms tend to get worse over time.

Alzheimer’s disease is the most common type of dementia, and it mostly affects the elderly. Each form of dementia has a different cause. Though dementia mostly affects older adults, it is not a part of normal ageing. An estimated 6.7 million older adults have Alzheimer's disease in the United States. That number is expected to double by 2060, as per data from the CDC.

In 2022, 3.8% of men and 4.2% women in US were diagnosed with dementia. The percentage of people increase with age from 1.7% for those aged 65-74 to 13.1% for those aged 85 and older. Alzheimer's accounts for 60 to 80% of all dementia cases and it is most prevalent in California, Florida, and Texas, as these states have the highest number of people.

For people living with alopecia areata, hair loss can be unpredictable, persistent, and difficult to treat. Now, amid lack of a definitive cure, a medicine originally developed for inflammatory diseases such as rheumatoid arthritis, is showing striking results in patients with severe alopecia areata.

Two large Phase III clinical trials involving 1,399 adults and adolescents found that the drug upadacitinib significantly improved scalp hair regrowth compared with placebo. The trial’s findings were published in JAMA Dermatology.

The results are both striking and promising as alopecia areata is an autoimmune condition, in which the immune system mistakenly attacks hair follicles.

How Can An Arthritis Drug Help Hair Grow?

Upadacitinib, sold under the brand name Rinvoq, belongs to a class of medicines called JAK inhibitors.

JAK proteins help transmit signals that are involved in immune and inflammatory responses. In alopecia areata, abnormal immune response contributes to the attack on hair follicles.

By blocking JAK1 signaling, upadacitinib can slow down some of these immune responses, potentially allowing damaged or suppressed hair follicles to resume producing hair for some time.

The drug is already used for other autoimmune conditions including rheumatoid arthritis, Crohn's disease and ulcerative colitis.

Its potential use in alopecia is an example of drug repurposing, where an existing medicine gets used for a completely different disease.

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How Much Hair Did Patients Regrow?

The Phase III programme included two parallel trials, UP-AA1 and UP-AA2, involving adults and adolescents with severe alopecia areata.

After 24 weeks, about 45% of patients taking 15 mg of upadacitinib achieved at least 80% scalp hair coverage. More than 54% of those taking 30 mg reached the same threshold.

In comparison, only about 2% of placebo recipients achieved that level of regrowth.

Researchers also reported improvements in eyebrow and eyelash hair and indirectly in quality of life

Strikingly, benefits were seen in people with severe disease, rather than only those with a few small bald patches. Severe alopecia areata in the trials was defined as hair loss affecting at least half of the scalp.

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What Does This Mean For Alopecia Areata Treatment?

Alopecia areata currently has no guaranteed permanent cure. And this trial does not mean that the condition can be cured.

The disease can follow a relapsing and unpredictable course, with hair growing back and then falling out again.

The new findings show that upadacitinib can promote substantial hair regrowth while patients are receiving treatment. They do not prove that the underlying autoimmune disease can be permanently eliminated.

There are already approved JAK inhibitors for alopecia areata, including baricitinib, ritlecitinib and deuruxolitinib, so upadacitinib would not be the first drug in this category.

Side Effects

The safety findings in the trials were consistent with the known safety profile of upadacitinib, and researchers reported no new safety concerns during the study period.

Common adverse events included upper respiratory infections, acne, increased creatine phosphokinase and nasopharyngitis.

But JAK inhibitors are powerful medicines that regulates immune system and are not something people should take simply because they are experiencing hair loss. Their risks and benefits need to be assessed by a doctor.

The Karnataka government has launched a QR code-based grievance system that allows consumers to lodge food and drug safety complaints directly with authorities. The move is aimed at making food and drug safety-related violations easier to report.

The Integrated Public Grievance Redressal System (IPGRS) was launched by Karnataka Health Minister U T Khader on August 17. The system has been developed by the state’s Food Safety and Drugs Administration (FSDA) in coordination with the Centre for e-Governance.

QR codes will be displayed at hotels, restaurants, eateries and drug stores, allowing customers to scan them and register complaints. They will also be able to track the status of complaints, according to officials.

What Can You Complain About?

The system is designed to cover both food and medicine-related violations. For food establishments, consumers can report:

• Unhygienic food or poor sanitation
• Food safety violations
• Use of artificial colours
• Problems at restaurants, hotels and street-food outlets
• Other food-related regulatory or service complaints
• For pharmacies and medicines, complaints can include:
• Expired medicines
• Overcharging or excessive pricing
• Adverse drug reactions
• Pharmacy-related grievances
• Other violations under the Drugs and Cosmetics Act

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Why Has Karnataka Introduced This Now?

The QR system comes as Karnataka's food safety authorities ramp up inspections across the state. In one recent operation, inspections at government facilities reportedly uncovered food safety problems, while canteens at Vidhana Soudha and the health department headquarters in Bengaluru were sealed after officials found expired food and unhygienic conditions, including cockroaches.

The move came after complaints about unhygienic food handling and the use of artificial colours in shawarma and kebabs.

During the checks, 61 samples were collected, with nine shawarma samples and one kebab sample subsequently declared unsafe. Officials said legal action is now being initiated against those responsible.

The department also turned its attention to food warehouses used by e-commerce platforms, inspecting 236 facilities and initiating proceedings against 44 for violations. Eight of these warehouses were fined a total of Rs 1.97 lakh after officials found unhygienic conditions.

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Concerns were also raised over milk and dairy products entering the state. Of the 25 samples collected from batches coming into Karnataka from Tamil Nadu, one was found to be substandard.

In Bengaluru Urban, inspection teams visited more than 60 three- and five-star hotels, eight warehouses and four international restaurants.

The inspections also uncovered large quantities of expired, spoiled and improperly labelled food. Officials seized 429 kg of mutton and chicken, 203 kg of fish, and 200 kg of vegetarian food that had been stored alongside non-vegetarian items.

The seized material also included 76 kg of rotten or mouldy vegetables, 45 litres of expired milk and curd, and 12 kg of expired bakery products. Another 67 kg of cereals and other food products were confiscated for being expired or mislabelled, while 49 litres of used or non-compliant cooking oil were also seized.

How Will The QR System Help?

Traditionally, consumers had to go through a complex complaint-lodging process to report an unsafe restaurant, suspicious food product or expired or harmful medicines. The new system essentially puts a digital window to lodge complaints right at the place where the problem is discovered.

A customer who notices poor hygiene at a restaurant, for example, can scan the QR code displayed at the establishment and submit the complaint without having to separately search for the relevant authority. The system is also intended to make complaints easier for officials to monitor and follow up on.

The state government has described the initiative as the first of its kind in India, with the system integrated with the government's Centre for e-Governance.

That could become particularly useful in a state where food is sold through a huge network of restaurants, street vendors, hotels, pharmacies and institutional kitchens.

Even as global temperatures continue to climb, increased exposure to extreme heat may be more dangerous for people aged 60 and over than previously thought, according to a new study published in The Lancet Planetary Health.

The global study found that older adults may face serious health risks as their bodies struggle to keep up with extreme heat, a state physiologists call “uncompensable heat stress.” This occurs when sweating and other biological cooling mechanisms are overwhelmed and core body temperature continues to rise.

“The human body can tolerate only a limited range of ambient heat,” said lead author Qinqin Kong from Stanford Health Policy (SHP).

“Understanding where, when, and to what extent these limits are exceeded is critical for informing climate prevention policies,” Kong said.

What Did The Study Find?

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The study accounts for age-related differences in heat tolerance on a global scale. Researchers drew on previously published laboratory experiments that measured heat tolerance across three age groups:

• Younger adults: 15–39 years
• Middle-aged adults: 40–59 years
• Older adults: 60 years and over

The researchers then mapped where heat would become dangerous for each group and how many people would be affected.

They used a high-resolution heat stress metric across scenarios ranging from 1°C to 4°C of global warming above pre-industrial levels, in 0.5°C increments, combined with population projections.

Based on at least 180 hours of dangerous heat annually, assuming roughly six hours of such heat per day:

• At 1.5°C warming: 22% of the world's older adults — about 290 million people — could face unsafe heat for at least one month each year.
• At 3°C or higher warming, older adults could face dangerous heat day and night for three months straight.
• A similar level of risk is not projected until 4°C warming, when about 17% (490 million people) could be affected.

Which Countries Will Be Most Affected?

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According to the study, South Asia and the Persian Gulf regions are projected to be among the most exposed.

At that level of warming, just four countries—India, China, Pakistan and Bangladesh—would account for 1.5 billion people, or 73% of the total population affected worldwide, across all age groups.

The researchers warned that the greatest challenge will fall on countries that combine high heat exposure with high poverty rates and limited access to cooling, including:

• India
• Pakistan
• Bangladesh
• Myanmar
• Niger

Why Are Older Adults at Higher Risk?

Each additional degree of warming exposes roughly 1 billion more people to at least 180 hours of uncompensable heat a year, with older adults bearing a disproportionate share of the risk.

When researchers accounted for the reduced heat tolerance associated with aging, the number of people facing repeated, uncompensable heat exposure was two to eight times higher than earlier estimates that used young-adult thresholds for everyone.

This is particularly concerning because extreme heat is already one of the leading causes of weather-related deaths worldwide. Heat-related mortality may also become the largest contributor to climate-related costs in a warming world.

Why Prolonged Heat Can Be Dangerous?

The researchers noted that sustained exposure beyond the body's heat tolerance limits can lead to dangerous or even fatal hyperthermia and can worsen pre-existing chronic illnesses, particularly those affecting the:

• Cardiovascular system
• Respiratory system
• Renal system

These findings underscore the urgent need for age-specific adaptation strategies alongside ambitious climate change-mitigation efforts to protect clinically vulnerable populations from escalating heat-related hazards.

The study calls on governments to develop heat emergency plans and improve access to cooling and heat-warning systems.

The team also stress that cutting emissions remains essential to reduce older people's risk of prolonged, round-the-clock heat exposure and protect future generations from widespread heat danger.