Pakistan continues to be dealing with a polio outbreak as four fresh cases have emerged, pushing the national tally to 37 this year, according to health officials on October 19, 2024. Health officials said that the regional reference laboratory for polio eradication at the National Institute of Health in Islamabad confirmed wild poliovirus type-1 (WPV1) in two children-one from each Balochistan and Khyber-Pakhtunkhwa.

In recent cases, a girl has been affected from Pishin, and two boys from Chaman and Noshki of Balochistan, and a girl from Lakki Marwat in KP. These are the first detections of the virus within Noshki and Lakki Marwat this year; isolated cases of poliovirus were previously reported within Chaman and Pishin. The province of Balochistan was the worst hit with 20 cases, Sindh had 10, Khyber Pakhtunkhwa had five, and Punjab and Islamabad had one case each.

A gigantic fight against polio has been on going in Pakistan- especially in Balochistan and southern KP-over the last two years. Immunisation campaigns have often been suspended or delayed because of local protests, insecurity, and community boycotts. Consequently, quite a number of children did not get the necessary vaccinations, making existing patches of vulnerability for the virus to flow within those pockets.

Noshki, located near Afghanistan's border, and Lakki Marwat have also recently reported some positive environmental samples that confirm the virus is present here, said a local reference laboratory official. Samples of latest cases are currently under genetic sequencing for checking spread of virus and origin.

As the threat of polio continues to grow, Pakistan has vowed to mount a nationwide campaign against it beginning from October 28. With the zeal to tackle the menace in the most effective manner, over 45 million children under the age of five will be vaccinated across the country.

Today, Afghanistan and Pakistan remain one of the few countries where polio has not yet been eradicated. The WHO said the virus remains a potential serious public health threat in areas with low vaccination coverage and weak surveillance.

India On Alert Against Polio

The country declared itself polio-free since 2014 and has kept the disease on bay almost a decade with very robust vaccination programs; however, two cases of vaccine-derived poliovirus cases reported in recent days from Meghalaya create some amount of doubts over a possible resurgence. Experts observe that in India, despite these detections taking place, strong coverage of vaccination at 90-95% and mandatory surveillance measures keep the risk of this widespread outbreak at bay.

The experts point out, however, that such stable situation in India requires continued surveillance. "Countries like Pakistan and parts of Africa remain at a high risk because vaccination rates in those areas are much lower," Dr. Siddharth, public health expert, said. Vaccination is an indispensable act in order to avoid the spread of this incapacitating disease that manifests most importantly as a nervous system affliction leading to the paralysis of a long period.

With concerted efforts from health authorities, there is hope someday that the scourge of polio will be completely eradicated from the face of the earth and future generations will never suffer from its effects.

Seven in 10 general practitioners in the United Kingdom believe adult attention-deficit/hyperactivity disorder (ADHD) is being overdiagnosed, according to a survey of 829 doctors.

The observation has reignited debate over the dramatic increase in adult ADHD referrals and diagnoses.

The survey, conducted by GP publication Pulse, found that 410 GPs described adult ADHD as “very overdiagnosed” while 173 considered it “slightly overdiagnosed”.

Only 50 said it was diagnosed about right, while 148 believed it was underdiagnosed to some degree.

Pulse said that the survey should be viewed as a GP's opinion rather than a proven scientific estimate of overdiagnosis.

The survey also found that GPs estimated an average of 81.3% of patients they referred to adult ADHD services eventually received a positive diagnosis.

But that figure does not mean that 81% of people with suspected ADHD have it. These patients had already been referred for an assessment by a specialist, meaning they had passed through an initial clinical screening process.

Doctors Are Concerned About ADHD Overdiagnosis In Adults

Some GPs responding to the survey raised concerns that assessments may sometimes be too narrow and focus on identifying ADHD without considering other conditions that can cause similar symptoms that could overlap with ADHD. These can include anxiety, depression, trauma and other mental health conditions.

One GP told Pulse that they were concerned about “superficial” assessments and whether patients’ histories of trauma or adverse childhood experiences were being considered accurately.

There are also concerns around the growing use of private assessment providers. Some GPs surveyed said they believed positive diagnosis rates were higher among private providers than NHS services, although these are individual doctors’ observations rather than evidence represented nationally.

At the same time, Dr Katie Bramall, chair of the BMA's GP committee, argued that a high positive diagnosis rate among referred patients is not necessarily evidence of overdiagnosis.

She said lengthy NHS waits may mean that only people who remain convinced that ADHD is affecting them significantly eventually reach assessment.

She also pointed to changing understanding of ADHD, including how it can present in women and adults, as one reason more people are being recognised.

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Is ADHD Being Overdiagnosed?

An interim report from the UK government's independent review of ADHD, autism and mental health conditions said recorded ADHD diagnoses in England have increased, particularly among younger adults and women.

The NHS's independent ADHD Taskforce has previously estimated adult ADHD prevalence at around 2-3%, while recorded diagnoses were significantly lower in earlier datasets. The taskforce concluded that under-recognition remained a problem.

The Royal College of Psychiatrists has also agreed that the rise in diagnoses should not be automatically interpreted as overdiagnoses of ADHD.

It has pointed to other factors like better awareness and improved recognition, while also addressing concerns about online self-assessment that may not be always accurate.

The government review therefore says that the current situation is more complex than simply labelling ADHD as either overdiagnosed or underdiagnosed. It highlights the lack of recent, large-scale representative data measuring adult ADHD prevalence in England.

On the other hand, demand for ADHD treatment continues to climb. NHS figures cited by Pulse show prescriptions for ADHD medicines increased by 29% between July 2025 and June 2026 compared with the previous 12 months, with an average of 238,000 patients receiving these medicines each month.

Also read: ADHD: Your Pupils May Explain How The Brain Handles Attention, Says New Indian Study

Signs of ADHD

For people asking themselves if they might have ADHD, one must look to medical sources over social media popularity. The NHS says that signs of ADHD in adults are most often:

• Difficulty with organization and time management
• Having trouble with following instructions
• Having trouble keeping one's focus on tasks and seeing them through
• Feeling restless or being impatient
• Risk-taking and being impulsive
• Trouble in relationships or in social situations

Medicine safety must become everyone’s responsibility, the Indian government said today while launching the Biovigilance Program to monitor adverse events linked to organ and tissue transplantation.

Under the program, the Indian Pharmacopoeia Commission (IPC) will lead efforts to strengthen the reporting, assessment, monitoring and prevention of adverse events associated with medicines and biological products used in organ and tissue transplantation, including products administered to donors and recipients.

Together, pharmacovigilance, materiovigilance and biovigilance initiatives will strengthen safety monitoring across medicines, medical devices and transplant procedures.

The program was launched by Union Minister of State for Health & Family Welfare and Chemicals & Fertilizers Anupriya Patel at the 6th National Pharmacovigilance Week organized by the IPC at Dr. Ambedkar International Centre in New Delhi.

New Medicine Safety Initiatives

Patel also launched initiatives to help healthcare professionals make informed, evidence-based decisions when prescribing and using medicines. These include:

• The 7th Edition of the National Formulary of India (NFI),
• The Guidance Document for Hospitals in India for Safety Monitoring and Reporting of Medical Device-Related Adverse Events,
• The ADR-PvPI 2.0 Mobile App for iOS users.

“Rational use of medicines and continuous safety monitoring are integral to public health,” said Patel. She added that “every patient must receive the right medicine, of assured quality, in the right manner and with the highest possible degree of safety”.

“The NFI serves as an important bridge between scientific standards and clinical practice, guiding healthcare professionals in the appropriate and rational use of medicines,” Patel said.

India’s Pharmacovigilance Network

Patel emphasized that medicine safety is a continuous responsibility—from the development and manufacture of a drug or medical device to its prescription, dispensing, use and post-market monitoring.

She also highlighted the country’s progress in pharmacovigilance, noting that “India has built a strong indigenous ecosystem capable of generating, collecting, processing and analyzing medicine-safety data from across the country”.

India has moved from the 123rd position during 2009–2014 to 8th globally in contributions to the WHO patient safety database, Patel said.

The Pharmacovigilance Program of India (PvPI), coordinated by the National Coordination Centre at IPC, systematically collects, assesses and analyzes adverse drug reaction information. The Materiovigilance Program of India (MvPI) monitors adverse events associated with medical devices.

AI And Patient Reporting

Patel said digital initiatives, including NFI Online, IP Online, ADR-PvPI 2.0 Mobile App and the Adverse Drug Reaction Monitoring System (ADRMS), are making medicine-related information and adverse-event reporting more accessible, transparent and responsive.

She called for greater use of emerging technologies, including artificial intelligence and advanced data analytics, to strengthen medicine-safety systems and enable timely generation and use of safety evidence.

The Minister also stressed the need to increase patient participation in adverse-event reporting. She noted that digital platforms, mobile applications and helplines have made reporting easier, and called for addressing the “missing link” of patient reporting.

"Around 1,150 ADR reporting centers are currently operational across public and private hospitals and medical colleges in the country, along with medical-device vigilance facilities. The government plans to expand these capabilities to the primary healthcare level," Patel said.

India’s Patient Safety Push

Referring to the vision of Viksit Bharat 2047, Patel said patient safety must remain a key national priority. She called for India to build on its position as the “pharmacy of the world” and aspire to become a global leader in pharmacovigilance sciences and patient safety.

“Medicine safety must become everyone’s responsibility. Every single reported event can save a life.”

She said collective participation would be critical to building a strong culture of medicine safety and promoting the rational use of medicines.

An LSD-based treatment has cleared its second Phase 3 trial for generalized anxiety disorder (GAD), sparking hope to bring the first new drug for the condition in nearly two decades closer to FDA approval.

Definium Therapeutics recently said that its drug DT120, a tablet containing lysergide, the pharmaceutical form of LSD, significantly reduced anxiety symptoms compared to placebo in the Panorama Phase 3 trial that included 245 participants.

The company said participants receiving a single 100-microgram dose had a 9.8-point reduction in their score on the Hamilton Anxiety Rating Scale (HAM-A) after 12 weeks, compared to a 4.7-point reduction among those receiving placebo. The difference with placebo was 5.1 points.

The improvement surfaced quickly as differences from placebo seen as early as Day 2 and sustained through the 12-week assessment.

A Promising Second Phase 3 Trial

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Panorama is the second positive Phase 3 trial for DT120 in GAD. An earlier Phase 3 study, called Voyage, also found a significant improvement in anxiety symptoms, with a placebo-adjusted difference in HAM-A of 5.4 points at 12 weeks.

Phase 3 trials are generally the pivotal studies in any research as they are used to provide evidence of a treatment's efficacy and safety before regulatory review and approval.

Rob Barrow, Chief Executive Officer of Definium Therapeutics, said, “The Panorama results again met our high expectations and confirmed the unprecedented efficacy of DT120 in GAD.”

Barrow added, “With strong positive results across four complementary studies, we have built a compelling body of evidence that increases our confidence in the potential best-in-class profile of DT120.”

The drug also hopes to bridge the long-overdue treatment gap in GAD. Definium says the last new drug approved for GAD was in 2007, meaning DT120 could potentially become the first newly approved GAD treatment in almost 20 years if it ultimately clears regulatory review.

Definium has a pre-New Drug Application meeting with the US Food and Drug Administration planned for the fourth quarter of 2026 and anticipates filing its application in the first half of 2027.

Barrow also said, “Building on this momentum, we are advancing toward an NDA submission and look forward to aligning with the FDA at our upcoming pre-NDA meeting. We are deeply grateful to the participants, investigators, site personnel, and our team whose commitment and hard work made this progress possible.”

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LSD-Based Treatment For GAD

DT120 is designed as a single-dose treatment rather than a daily tablet. In the Panorama trial, participants were monitored for at least eight hours after dosing because LSD can temporarily lead to certain cognitive and emotional changes.

Among those receiving 100 micrograms, the average time to meet the study's end-of-session criteria was 6.2 hours, while 94% met those criteria within eight hours.

The treatment works through the serotonin 5-HT2A receptor, although exactly how LSD produces longer-lasting improvements in psychiatric symptoms remains unclear.

The company reported that DT120 was generally well tolerated. It also said that side-effects were mild to moderate, temporary and occurring mainly on the day of dosing.

Among people receiving the 100-microgram dose, common adverse events on dosing day included illusions in 68%, nausea in 37% and headache in 24%. There were no drug-related serious adverse events or signals of increased suicidality in the trial, according to Definium.

It is important to know that these results are reported by the company, and the complete data will need regulatory and scientific scrutiny for the drug’s approval.