Pakistan continues to be dealing with a polio outbreak as four fresh cases have emerged, pushing the national tally to 37 this year, according to health officials on October 19, 2024. Health officials said that the regional reference laboratory for polio eradication at the National Institute of Health in Islamabad confirmed wild poliovirus type-1 (WPV1) in two children-one from each Balochistan and Khyber-Pakhtunkhwa.

In recent cases, a girl has been affected from Pishin, and two boys from Chaman and Noshki of Balochistan, and a girl from Lakki Marwat in KP. These are the first detections of the virus within Noshki and Lakki Marwat this year; isolated cases of poliovirus were previously reported within Chaman and Pishin. The province of Balochistan was the worst hit with 20 cases, Sindh had 10, Khyber Pakhtunkhwa had five, and Punjab and Islamabad had one case each.

A gigantic fight against polio has been on going in Pakistan- especially in Balochistan and southern KP-over the last two years. Immunisation campaigns have often been suspended or delayed because of local protests, insecurity, and community boycotts. Consequently, quite a number of children did not get the necessary vaccinations, making existing patches of vulnerability for the virus to flow within those pockets.

Noshki, located near Afghanistan's border, and Lakki Marwat have also recently reported some positive environmental samples that confirm the virus is present here, said a local reference laboratory official. Samples of latest cases are currently under genetic sequencing for checking spread of virus and origin.

As the threat of polio continues to grow, Pakistan has vowed to mount a nationwide campaign against it beginning from October 28. With the zeal to tackle the menace in the most effective manner, over 45 million children under the age of five will be vaccinated across the country.

Today, Afghanistan and Pakistan remain one of the few countries where polio has not yet been eradicated. The WHO said the virus remains a potential serious public health threat in areas with low vaccination coverage and weak surveillance.

India On Alert Against Polio

The country declared itself polio-free since 2014 and has kept the disease on bay almost a decade with very robust vaccination programs; however, two cases of vaccine-derived poliovirus cases reported in recent days from Meghalaya create some amount of doubts over a possible resurgence. Experts observe that in India, despite these detections taking place, strong coverage of vaccination at 90-95% and mandatory surveillance measures keep the risk of this widespread outbreak at bay.

The experts point out, however, that such stable situation in India requires continued surveillance. "Countries like Pakistan and parts of Africa remain at a high risk because vaccination rates in those areas are much lower," Dr. Siddharth, public health expert, said. Vaccination is an indispensable act in order to avoid the spread of this incapacitating disease that manifests most importantly as a nervous system affliction leading to the paralysis of a long period.

With concerted efforts from health authorities, there is hope someday that the scourge of polio will be completely eradicated from the face of the earth and future generations will never suffer from its effects.

A research team at Stanford School of Medicine has reported an experimental treatment that appears to stop type 1 diabetes in its tracks in mice. The method not only prevented the disease in animals on the verge of developing it, but also restored normal blood sugar levels in mice already living with full-blown diabetes.

The approach stands out because it merges immune cells from the patient and a donor, creating a shared immune system that accepts the transplanted tissue without heavy immunosuppressive drugs. The mice remained stable for at least four months, which is considered significant in early-stage diabetes research.

Scientists believe the strategy could eventually help humans living with type 1 diabetes and may also support safer organ transplantation, as per Science Direct.

What Is Stem Cell Therapy For Diabetes?

Stem cell therapy for diabetes aims to rebuild the body’s ability to make its own insulin by creating new, working beta cells in the pancreas. In this method, stem cells collected from sources such as bone marrow or umbilical cord blood are guided to develop into insulin-producing cells. These cells are then placed into the patient’s body to help regulate blood sugar more naturally. According to the National Institutes of Health, this approach may lessen a person’s dependence on insulin shots and other diabetes medicines.

How the Hybrid Immune System Works?

Type 1 diabetes develops when the body’s own defense system begins to destroy insulin-producing beta cells in the pancreas. Replacing these cells through islet transplantation is a known option, but the recipient’s immune system often attacks the donor cells as well.

In this study, researchers first “soft-reset” the mouse immune system with a preparation process that included a targeted immune inhibitor, a small dose of radiation, and selected antibodies. Once the animals were conditioned, scientists infused a mix of donor blood stem cells and donor islet cells.

This created a blended immune environment where the new islet cells were not treated as intruders. The mice regained the ability to regulate blood sugar, and the transplanted tissue stayed largely free from destructive inflammation.

Why the Findings Matter

Lead researcher Seung Kim explained that the method addresses two challenges at once. It replaces the lost insulin-producing cells and calms the autoimmune process that caused the damage in the first place. None of the animals developed graft-versus-host disease, a serious complication that often appears in cross-donor cell therapies in humans.

The results build on earlier studies suggesting that donor-recipient immune cell combinations can help prevent transplant rejection. The promising outcome raises hope for human trials, although several hurdles remain.

What Still Needs to Be Solved?

Islet cells for transplantation can only be collected after a donor’s death, and they must come from the same person who provides the blood stem cells. The number of cells required for a human-scale procedure is also unclear.

Researchers are now exploring ways to improve the survival of donor cells and to grow replacement cells from pluripotent human stem cells in the lab. The team believes these steps could bring this treatment closer to clinical use.

Kim called the possibility of adapting the findings for people “very encouraging,” noting that some of the immune-reset techniques used in the study already exist in clinical care for other conditions.

Health Secretary Robert F. Kennedy Jr. told The New York Times that he personally instructed the U.S. Centers for Disease Control and Prevention to revise its long-standing message that vaccines do not cause autism. His disclosure, published Friday, confirms who was behind the surprising shift that caught many current and former CDC employees off guard earlier in the week.

Kennedy, who has a long history of opposing routine vaccination, has increasingly unsettled the public health agencies he now leads. His recent moves have raised concerns across the medical community, which sees many of his decisions as placing Americans at risk.

CDC Website Autism Vaccine Claim: What Kennedy Said and What Changed

In the interview, Kennedy dismissed the CDC’s previous guidance, calling the agency’s long-held position on vaccine safety “a lie.” The CDC’s updated “vaccine safety” page now argues that the statement “vaccines do not cause autism” cannot be proven with absolute certainty and implies that officials have disregarded research that hints at a possible link, as per CNN.

This new language conflicts with decades of scientific evidence and goes against the consensus view shared by independent researchers, pediatric groups and global health authorities.

How the Scientific Community Responded

Public health experts reacted sharply, warning that the revisions distort how evidence is evaluated in science. Researchers emphasized that while science cannot prove a negative, extensive data can rule out likely causes, and that is what has happened in the case of vaccines and autism, as per CNN.

Autism advocacy groups called the claim misleading. The Autism Science Foundation repeated that vaccines remain one of the most thoroughly investigated environmental factors linked to autism and that research across many countries and large populations has consistently found no association.

What the Science Actually Shows About Vaccines and Autism

Scientists have studied vaccines and autism for more than two decades. Large population studies in the United States, Europe and Asia have looked at the measles, mumps and rubella (MMR) vaccine, thimerosal-containing vaccines, and the timing of childhood immunization. Each line of research has reached the same conclusion: vaccines do not cause autism.

These findings have come from independent academic teams, government-funded studies and international health agencies, using different methods, age groups and datasets. Experts say the updated CDC wording misrepresents this evidence and may create unwarranted fear among parents, as per CNN.

A Promise Broken

Kennedy had previously assured Sen. Bill Cassidy, who chairs the Senate health committee, that he would keep the statement “vaccines do not cause autism” on the CDC website during his confirmation process. While the line remains, it now appears with a disclaimer noting that it was kept there specifically because of their agreement.

Cassidy said he opposed the update after Kennedy informed him of the change. The senator later warned that parents need clear reassurance, not confusion, especially on diseases like measles, polio and hepatitis B, where vaccination is proven to prevent severe illness.

A Wider Pattern of Disruption

The CDC website change is only one part of a broader shift under Kennedy’s leadership. He has withdrawn half a billion dollars from vaccine development initiatives, removed every member of a federal vaccine advisory panel, and signaled plans to overhaul the national vaccine injury compensation program.

He also dismissed former CDC Director Susan Monarez within weeks of her appointment after policy disagreements.

RFK Jr. Claims About The Vaccine Has Growing Distrust Within Medicine

Leaders in pediatrics and infectious disease warned Thursday that the new website language fuels misinformation rather than clarifying public health advice. Dr. Sean O’Leary of the American Academy of Pediatrics called the change “madness” and said it undermines confidence in the nation’s most basic health protections.

The Department of Health and Human Services did not respond to requests for comment.

As of 12pm on November 22, Delhi's AQI according to aqi.in is recorded at 315, with PM2.5 recorded at 225, and PM10 recorded at 296. The levels are still under the category 'Hazardous' and is equivalent to smoking 10.8 cigarettes a day, 75.6 cigarettes a week, and 324 cigarettes a month.

Amid all this, in an interview with the news agency ANI, AIIMS doctor called Delhi's deteriorating air quality as a "medical emergency". The doctors have warned that the crisis has intensified to a level where existing government measures are no longer enough. Prof Dr Anant Mohan, who heads the Department of Pulmonary, Critical Care, and Sleep Medicine, and Dr Saurabh Mittal of the same department at AIIMS said that city's continuously worsening pollution could pose serious threats to the vulnerable, including pregnant women, unborn and newborn child, and other adults, especially the ones with cardiac or neurological conditions.

Impact Could Be Generational

Dr Mohan highlighted that the exposure could lead to impacts which could be felt for generations. He said that the alarming effect is being seen on pregnant women, and that the pollutant, since the particles are so small, could pass through mother to the child in the fetus and could affect their growth.

The doctor pointed out that babies who are exposed to such a condition in womb have a higher chance of being born under weight, and their lungs may continue to remain weak as they grow. There could be other complications too, which might only be noted as the child grows old.

Dr Mittal said that the effects of air pollution now reach far beyond respiratory issues. He noted that prolonged exposure to toxic air has triggered rising cases of breathlessness, lung inflammation, asthma attacks, and chronic conditions like COPD. Fine particulate matter is also entering the bloodstream, raising the risk of heart attacks and strokes.

What Can You Do?

Wear N-95 Mask

The doctors are advising to wear an N-95 mask whenever someone is stepping outdoors. He mentions that a cloth or a surgical mask won't protect them against the pollutants, as N-95 masks are the only protective gears with filters that can keep the pollutants out when you breathe.

Skip Your Morning Walk

Pollution is the highest in the morning. This happens because pollutants accumulate overnight, and without wind or sunlight, PM2.5 or the particulate matter stays trapped near the ground, leading to pollution being at its peak by sunrise. As per the data by aqi.in, highest AQI is always registered between 6am to 9am.

Use Wet Mopping

Dry dusting could push the particles back up into the air, thus using a wet mop would reduce the dust particles and prevent it from being released in the air.

Vitamin C Supplements

A 2007 study published in the Journal of the Royal Society of Medicine noted that vitamin C or its supplement could in fact help patients with pneumonia or other lung-related disease. Thus vitamin C is a good boost for when lungs are at high risk, all thanks to the pollution.

Furthermore, the doctors suggest to keep hydrating yourself and use air purifier if one can afford it.