Polio Outbreak in Pakistan
Pakistan continues to be dealing with a polio outbreak as four fresh cases have emerged, pushing the national tally to 37 this year, according to health officials on October 19, 2024. Health officials said that the regional reference laboratory for polio eradication at the National Institute of Health in Islamabad confirmed wild poliovirus type-1 (WPV1) in two children-one from each Balochistan and Khyber-Pakhtunkhwa.
In recent cases, a girl has been affected from Pishin, and two boys from Chaman and Noshki of Balochistan, and a girl from Lakki Marwat in KP. These are the first detections of the virus within Noshki and Lakki Marwat this year; isolated cases of poliovirus were previously reported within Chaman and Pishin. The province of Balochistan was the worst hit with 20 cases, Sindh had 10, Khyber Pakhtunkhwa had five, and Punjab and Islamabad had one case each.
A gigantic fight against polio has been on going in Pakistan- especially in Balochistan and southern KP-over the last two years. Immunisation campaigns have often been suspended or delayed because of local protests, insecurity, and community boycotts. Consequently, quite a number of children did not get the necessary vaccinations, making existing patches of vulnerability for the virus to flow within those pockets.
Noshki, located near Afghanistan's border, and Lakki Marwat have also recently reported some positive environmental samples that confirm the virus is present here, said a local reference laboratory official. Samples of latest cases are currently under genetic sequencing for checking spread of virus and origin.
As the threat of polio continues to grow, Pakistan has vowed to mount a nationwide campaign against it beginning from October 28. With the zeal to tackle the menace in the most effective manner, over 45 million children under the age of five will be vaccinated across the country.
Today, Afghanistan and Pakistan remain one of the few countries where polio has not yet been eradicated. The WHO said the virus remains a potential serious public health threat in areas with low vaccination coverage and weak surveillance.
The country declared itself polio-free since 2014 and has kept the disease on bay almost a decade with very robust vaccination programs; however, two cases of vaccine-derived poliovirus cases reported in recent days from Meghalaya create some amount of doubts over a possible resurgence. Experts observe that in India, despite these detections taking place, strong coverage of vaccination at 90-95% and mandatory surveillance measures keep the risk of this widespread outbreak at bay.
The experts point out, however, that such stable situation in India requires continued surveillance. "Countries like Pakistan and parts of Africa remain at a high risk because vaccination rates in those areas are much lower," Dr. Siddharth, public health expert, said. Vaccination is an indispensable act in order to avoid the spread of this incapacitating disease that manifests most importantly as a nervous system affliction leading to the paralysis of a long period.
With concerted efforts from health authorities, there is hope someday that the scourge of polio will be completely eradicated from the face of the earth and future generations will never suffer from its effects.
Credits: Gemini
A major claim from China has sparked global curiosity and debate after a Shenzhen-based biotechnology company announced that it has developed a longevity pill capable of significantly slowing ageing.
A biotechnology company in Shenzhen, China, has caught worldwide attention by claiming to have created a pill that could dramatically slow the ageing process. According to the firm, the pill may one day help humans live up to 150 years by targeting ageing at the cellular level.
As per The Independent, Lonvi Biosciences says its formula focuses on ‘zombie cells’—aged cells that refuse to die, causing inflammation and age-related illnesses. Let’s take a closer look at the pill and explore whether this ambitious claim could be possible.
The Shenzhen-based company, part of China’s rapidly growing longevity industry, claims it has produced a pill that could theoretically stretch human life to 150 years. The formula targets so-called “zombie cells”—older cells that resist dying, leading to inflammation and disease associated with ageing. “This is not just another pill. This is the Holy Grail,” said CEO Ip Zhu, calling the capsule a breakthrough that could make extreme longevity achievable. The main ingredient comes from grape seeds and has shown in lab studies to extend lifespan in animals by delaying age-related diseases. Lonvi’s researchers suggest that taking the pill in adulthood could push life expectancy past 120, while starting from birth could surpass 150.
The pill contains procyanidin C1 (PCC1), a compound extracted from grape seeds. In experiments with mice, Lonvi claims the treatment increased overall lifespan by 9.4%, with a remarkable 64% improvement when dosing started from the very beginning. Lyu Qinghua, Lonvi’s chief technology officer, told The New York Times that reaching 150 is “definitely realistic” and could be possible “within a few years.”
China has made anti-ageing research a national priority, with President Xi Jinping reportedly discussing it with Russian President Vladimir Putin. Anti-ageing research, combined with AI and biotech, has quickly moved from niche interest to mainstream focus in the country.
A study in Nature Metabolism showed that procyanidin C1 from grape seed extract successfully extended both the lifespan and health span of mice, paving the way for future clinical trials.
Cellular senescence plays a key role in ageing, occurring when cells can no longer perform their functions. In recent years, researchers have identified drugs called senolytics, which can eliminate these senescent cells in the lab and in animal studies. This approach is an important step toward reducing age-related chronic diseases and could play a critical role in extending lifespan.
While the company’s claims have not yet been tested in human trials, scientists believe the approach holds promise for extending life. Lonvi’s researchers say the PCC1 pill can boost cellular health, delay deterioration, and maintain energy production over time. They suggest that when combined with a healthy lifestyle, the pill could help people live beyond 100, and possibly even past 120, while also reducing diseases linked to ageing.
Credits: Canva
A cheese brand has recalled one of its products over a serious health risk. Face Rock Creamery LLC has announced a voluntary recall of its Vampire Slayer Garlic Cheddar, according to a recent notice shared by the United States Food and Drug Administration. The decision came after the FDA detected Listeria monocytogenes in the area where the cheese was packed. The cheese is being pulled from shelves due to listeria contamination, which has also been linked to recent deaths in the United States, as reported by The Independent.
Only 16 units of the affected cheese were sold at the Face Rock flagship outlet at 680 2nd St. SE, Bandon, Oregon. Shoppers can identify the recalled product by its UPC code 8 512222 00547 8, according to the FDA.
These six ounce blocks were sold between November 10 at 3:30 p.m. PT and November 13 at 3:30 p.m. PT. Although no illnesses have been confirmed so far, customers who purchased the cheese are advised to discard it or bring it back to the store for a complete refund.
The item under recall is the Vampire Slayer Garlic Cheddar with a use by date of November 4, 2026, and the UPC 8 512222 00547 8. Face Rock Creamery stated that it is committed to strict food safety practices and transparency and that it is cooperating with authorities while taking immediate action to secure its production setting, according to The Independent. As of November 18, the FDA had not received any reports of illness tied to this cheese.
The recall notice on the FDA website explains that listeria infections can be dangerous and may be fatal for young children, older adults, and individuals with weakened immunity. It also states that healthy people might experience short-term problems such as high fever, strong headache, stiffness, nausea, stomach pain and diarrhea. For pregnant women, listeria can lead to miscarriages or stillbirths.
Listeria is a bacteria found in soil, water and animals that can contaminate food and cause listeriosis, a serious infection, as per World Health Organization. It poses a higher risk for pregnant women, newborns, older adults and people with weakened immune systems because it can live and grow even at refrigerator temperatures.
People usually become sick after eating contaminated items such as soft cheeses, deli meats or unpasteurized milk. Symptoms may be mild or flu-like, but the infection can lead to dangerous problems, including meningitis.
In the United States, listeria is the third leading cause of death linked to foodborne illness and is responsible for about 260 deaths each year. Many food products have been recalled in the past few months due to listeria concerns. As per USA Today, six people have died in a multistate outbreak connected to recalled prepared pasta dishes sold at large chains including Albertsons, Kroger, Sprouts Farmers Market and Trader Joe’s.
Federal officials reported at least 27 infections across 18 states, and CNN noted that a pregnant woman lost her fetus after becoming sick.
Symptoms of listeriosis often begin with fever, chills, muscle pain, nausea or diarrhea. In more severe cases, the infection can spread beyond the digestive system and may cause intense headache, stiff neck, confusion, seizures and widespread infection that leads to organ failure. Pregnant women may have only mild flu-like signs, yet the infection can cause serious harm to the developing fetus.
Credits: Canva
A new global study in The Lancet’s eClinicalMedicine has drawn serious concern about the sharp rise of antimicrobial resistance (AMR) in India, placing the country at the centre of what many specialists now consider a fast-moving superbug crisis. The research, titled Preprocedural screening for multidrug-resistant organisms in endoscopic retrograde cholangiopancreatography: an international, multicentre, cross-sectional observational study, shows that Indian patients had the highest worldwide rates of multidrug-resistant organisms (MDROs) among those undergoing a common endoscopic procedure.
These numbers far exceed the levels documented in Italy, the United States and the Netherlands.
A superbug is a strain of bacteria that no longer responds to one or more groups of antibiotics that previously worked well. This can happen through enzyme production such as carbapenemases, changes in drug targets, increased pumping out of drugs or shifts in the cell wall that block antibiotics from entering, as per National Institute of Health. When bacteria gain resistance to several antibiotic classes, the list of possible treatments becomes very small. Such resistance makes infections tougher to manage because routine medicines no longer work, leading to more severe illness.
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The recent Lancet paper used screening of patients scheduled for endoscopic retrograde cholangiopancreatography (ERCP), a frequently performed procedure, to highlight how widespread MDROs already are among Indian patients even before major interventions.
The study assessed more than 1,200 patients across India, Italy, the Netherlands and the United States. Among them, 83.1 per cent of Indian patients carried at least one superbug, a figure far higher than those in the other countries.
A few resistant pathogens account for most of the problem in the country, as per The Lancet Study:
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Enterobacterales, especially Klebsiella pneumoniae and Escherichia coli: These cause a large share of urinary tract infections, bloodstream infections and hospital-related illnesses. The study noted that nearly 70.2 per cent of Indian patients carried ESBL-producing strains.
Carbapenem-resistant Gram-negatives (CRGNs): India’s carbapenem-resistance rate for key pathogens was around 23.5 per cent, signalling that even some last-resort drugs fail against these infections.
Acinetobacter baumannii and Pseudomonas aeruginosa: These are common in intensive care units, often highly resistant and linked with ventilator-associated pneumonia. Surveillance in India shows very high resistance levels in both.
Staphylococcus aureus (MRSA, or methicillin-resistant Staph. aureus): This remains an established cause of surgical site and hospital-acquired infections.
Together, these organisms form part of the “ESKAPE” group (Enterococcus, Staph. aureus, Klebsiella, Acinetobacter, Pseudomonas and Enterobacter), which represents the central challenge in antibiotic resistance. India’s unusually high carriage and infection rates of these pathogens increase the threat both in hospitals and in the community, as highlighted in The Lancet study.
Resistance may be inevitable, yet it can still be controlled. The new findings make it clear that India cannot afford further delays. Antibiotic resistance is no longer a niche concern. With such high carriage levels, every hospital visit becomes a potential source of spread and every procedure carries added risk. Officials often speak about “containing resistance,” but the timeframe to act is shrinking. Without stronger antibiotic stewardship, timely diagnostics and firm infection-control practices, the country may lose access to many dependable first-line antibiotics for everyday infections, undoing years of medical progress.
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