Polio Outbreak in Pakistan
Pakistan continues to be dealing with a polio outbreak as four fresh cases have emerged, pushing the national tally to 37 this year, according to health officials on October 19, 2024. Health officials said that the regional reference laboratory for polio eradication at the National Institute of Health in Islamabad confirmed wild poliovirus type-1 (WPV1) in two children-one from each Balochistan and Khyber-Pakhtunkhwa.
In recent cases, a girl has been affected from Pishin, and two boys from Chaman and Noshki of Balochistan, and a girl from Lakki Marwat in KP. These are the first detections of the virus within Noshki and Lakki Marwat this year; isolated cases of poliovirus were previously reported within Chaman and Pishin. The province of Balochistan was the worst hit with 20 cases, Sindh had 10, Khyber Pakhtunkhwa had five, and Punjab and Islamabad had one case each.
A gigantic fight against polio has been on going in Pakistan- especially in Balochistan and southern KP-over the last two years. Immunisation campaigns have often been suspended or delayed because of local protests, insecurity, and community boycotts. Consequently, quite a number of children did not get the necessary vaccinations, making existing patches of vulnerability for the virus to flow within those pockets.
Noshki, located near Afghanistan's border, and Lakki Marwat have also recently reported some positive environmental samples that confirm the virus is present here, said a local reference laboratory official. Samples of latest cases are currently under genetic sequencing for checking spread of virus and origin.
As the threat of polio continues to grow, Pakistan has vowed to mount a nationwide campaign against it beginning from October 28. With the zeal to tackle the menace in the most effective manner, over 45 million children under the age of five will be vaccinated across the country.
Today, Afghanistan and Pakistan remain one of the few countries where polio has not yet been eradicated. The WHO said the virus remains a potential serious public health threat in areas with low vaccination coverage and weak surveillance.
The country declared itself polio-free since 2014 and has kept the disease on bay almost a decade with very robust vaccination programs; however, two cases of vaccine-derived poliovirus cases reported in recent days from Meghalaya create some amount of doubts over a possible resurgence. Experts observe that in India, despite these detections taking place, strong coverage of vaccination at 90-95% and mandatory surveillance measures keep the risk of this widespread outbreak at bay.
The experts point out, however, that such stable situation in India requires continued surveillance. "Countries like Pakistan and parts of Africa remain at a high risk because vaccination rates in those areas are much lower," Dr. Siddharth, public health expert, said. Vaccination is an indispensable act in order to avoid the spread of this incapacitating disease that manifests most importantly as a nervous system affliction leading to the paralysis of a long period.
With concerted efforts from health authorities, there is hope someday that the scourge of polio will be completely eradicated from the face of the earth and future generations will never suffer from its effects.
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English singer-songwriter Robbie Williams has opened up about being diagnosed with “a little bit of autism” and shared his struggles with intrusive thoughts.
The 52-year-old singer revealed that he had earlier been diagnosed with ADHD, as well as Tourette’s syndrome, the Daily Mail reported.
Speaking at the launch of his clothing brand Hopeium at Flannels, Williams said his autism diagnosis has helped explain some of his behaviors.
“I have ADHD and I just found out I have a bit of autism as well, which I actually f*****g love because it explains so much,” he said.
The British pop icon said he now sees the diagnosis as an explanation for “all the weird” things he does. He also described how ADHD affects his ability to concentrate.
“With the ADHD you can completely and utterly concentrate on something 1000 per cent, but with absolutely everything else, you just cannot do it. Ask my kids,” he said.
The singer said he is “completely and utterly obsessed with creating images and making funny things”.
Williams, who has won a record 18 BRIT Awards, said creativity helps him redirect his thoughts and avoid focusing on things that make him panic or feel scared.
“My brain is incredibly creative, and it can be creative about everything in the world that you panic or are scared about,” he said.
He gave the example of sitting on a plane and having an intrusive thought about possessing telekinetic powers and causing the plane to crash.
He said he has learned to “train my brain to do something better” rather than focusing on worrying thoughts.
Autism is a neurodevelopmental condition that can affect communication, social interaction and behavior. It is a spectrum, meaning symptoms and their severity can vary widely between individuals.
Common characteristics can include repetitive behaviors or interests, difficulty with changes in routine and challenges in social situations.
Williams has also previously spoken about being diagnosed with Tourette’s syndrome. In a recent podcast, he said he had realized that some of the intrusive thoughts he experiences may be connected to Tourette’s, although he does not experience the typical outward tics.
“I've just realized that I have Tourette's, but they don't come out. They are intrusive thoughts that happen,” Williams said.
He also spoke about struggling to fully take in the reaction of audiences, despite performing in front of large crowds.
Williams has said he was diagnosed with ADHD three times because he “forgot” that he had previously been told he had the condition. He first recalled being diagnosed around 2006 after recognizing ADHD symptoms while reading about the condition online.
After his diagnosis, he said he began taking a large number of tablets in the hope that they would “fix” him. He later said his substance misuse escalated, including crushing and snorting the pills.
Williams has faced several addictions and has had multiple stays in rehabilitation since rising to fame in the early 1990s.
ADHD is a neurodevelopmental condition that can involve persistent difficulties with attention, organization and impulse control.
Symptoms can include being easily distracted, forgetfulness, losing things and difficulty maintaining concentration. Some people may also experience restlessness and impulsive behavior.
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A 40-year-old woman developed a rare and potentially life-threatening “flesh-eating” infection of the genital and perineal region about a week after shaving her bikini line and an application of herbal preparation.
The woman, a mother of four with a BMI of 39 kg/m², was diagnosed with Fournier gangrene, a severe form of necrotizing fasciitis that can rapidly destroy soft tissue around the genitals and perineum.
She spent 77 days in hospital undergoing treatment, wound care and reconstruction. Complete wound healing was documented by Day 121, reported doctors from King Saud University in Riyadh, Saudi Arabia, in the American Journal of Case Reports.
The woman presented with worsening pain and swelling of the left labia that had spread toward the area above the pubic bone. She also experienced vomiting and lower abdominal pain.
About a week before admission, she had undergone perineal shaving and had a herbal preparation applied to her vulva by an alternative practitioner. She had not used antibiotics or other topical treatments before seeking medical care.
On admission, her heart rate was elevated at 140 beats per minute, although she had no fever and her blood pressure remained normal. Examination showed marked tenderness and swelling, while laboratory tests indicated a significant inflammatory response.
Samples taken from the infected wound grew several different types of bacteria (E. coli, Klebsiella pneumoniae, and Enterobacter cloacae). However, no bacteria were detected in her bloodstream.
After doctors diagnosed her with Fournier gangrene, they performed urgent surgical debridement to remove the affected tissue.
She subsequently underwent multiple surgical re-explorations and negative-pressure wound therapy.
She was initially given broad-spectrum antibiotics, and later amoxicillin-clavulanate.
Fournier gangrene is a rare, rapidly progressive form of necrotizing fasciitis affecting the perineum and external genitalia. It is often described as a “flesh-eating” infection because bacteria can cause rapid destruction of skin and underlying soft tissue.
The condition is much more common in men, but women can also develop it. Reported male-to-female ratios range from 10:1 to 40:1.
Risk factors include diabetes, obesity, immunosuppression, malnutrition, peripheral vascular disease, kidney disease, malignancy and other serious underlying conditions. However, Fournier gangrene can also occur in people without the classic risk factors.
Local trauma, disruption of the skin barrier and invasive or cosmetic procedures can potentially provide an entry point for infection.
The researchers noted that Fournier gangrene may be underrecognized in women, partly because its symptoms can initially resemble a gynecological condition.
Early symptoms may include severe pain, swelling, redness and tenderness around the genital or perineal area. As the infection progresses, tissue destruction, skin discoloration, blisters or systemic signs of severe infection may develop.
"While men are more frequently affected, women should not be assumed to be at low risk. Severe or rapidly worsening pain and swelling around the genital or perineal region, particularly when accompanied by systemic symptoms, warrants urgent medical evaluation," the team said.
Treatment generally requires emergency surgical removal of dead and infected tissue along with broad-spectrum antibiotics and intensive supportive care. Survivors may require multiple operations, prolonged hospitalisation and complex wound management.
Fournier gangrene is a medical emergency. Although rare, it can progress rapidly and become fatal if treatment is delayed.
The condition has historically been associated with high mortality, with risk increasing when diagnosis and surgical treatment are delayed.
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A 62-year-old man in Australia died after his urgent heart surgery was cancelled twice. A state coroner later found that failures in an overworked health system contributed to his death.
Petar Josipovic had been diagnosed with moderate-to-severe aortic regurgitation and coronary artery disease. He was placed on the cardiothoracic surgery waiting list at Royal Adelaide Hospital as a Category 1 patient, meaning his surgery was expected to take place within 30 days.
However, his operation, initially scheduled for August 14, 2023, was cancelled twice to make room for higher-priority emergency patients. It was eventually rescheduled for August 25.
The day before his surgery, Josipovic was rushed to the emergency department after his condition deteriorated and suffered a cardiac arrest.
Doctors performed an emergency aortic valve replacement and coronary artery bypass surgery, but he developed severe complications and died about three weeks later in the ICU.
South Australian State Coroner David Whittle found that Josipovic's death was potentially preventable and called for a sweeping independent review of how cardiac surgery patients are assessed, listed and managed while waiting for operations.
The coroner, however, did not attribute the repeated cancellations to individual negligence. “I do not make any finding that the decisions that led to the cancellations were the result of ill-will or lack of due care,” Whittle said.
Instead, he said a health system under immense pressure was bound to have systemic failures. He also said that staff were unable to recognise the extent of the patient's deterioration before it was too late.
Also read: Stopping Statins After 75 May Not Raise Death Risk In Low-Risk Adults: The Lancet Study
The inquest heard that reduced intensive care capacity had put additional pressure on the cardiothoracic service. ICU capacity reportedly fell from 24 beds to 16 following the move to the new hospital site, meaning urgent procedures could be postponed when beds were unavailable.
Josipovic's case also highlighted the problem of keeping track of patients whose condition worsens while they remain on surgical waiting lists.
The coroner noted that Josipovic had been advised to attend the emergency department on occasions but did not do so. This meant clinicians did not have the opportunity to physically reassess his condition and fully appreciate how much his risk had increased.
Whittle recommended an independent external review of cardiothoracic surgical listing practices, covering the patient's entire medical history from referral and assessment to waiting-list management and hospital resources.
He also called for standard guidelines across South Australia's health networks so staff know exactly what advice to provide when patients waiting for surgery report that their condition is worsening.
The case has renewed concerns about what happens when hospitals have to balance urgent operations against limited beds and resources.
The case has also highlighted an important issue. For patients waiting for time-sensitive procedures, a delay is not always simply a longer wait. In some cases, the patient's clinical condition can change while they remain on the list
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