Polio Outbreak in Pakistan
Pakistan continues to be dealing with a polio outbreak as four fresh cases have emerged, pushing the national tally to 37 this year, according to health officials on October 19, 2024. Health officials said that the regional reference laboratory for polio eradication at the National Institute of Health in Islamabad confirmed wild poliovirus type-1 (WPV1) in two children-one from each Balochistan and Khyber-Pakhtunkhwa.
In recent cases, a girl has been affected from Pishin, and two boys from Chaman and Noshki of Balochistan, and a girl from Lakki Marwat in KP. These are the first detections of the virus within Noshki and Lakki Marwat this year; isolated cases of poliovirus were previously reported within Chaman and Pishin. The province of Balochistan was the worst hit with 20 cases, Sindh had 10, Khyber Pakhtunkhwa had five, and Punjab and Islamabad had one case each.
A gigantic fight against polio has been on going in Pakistan- especially in Balochistan and southern KP-over the last two years. Immunisation campaigns have often been suspended or delayed because of local protests, insecurity, and community boycotts. Consequently, quite a number of children did not get the necessary vaccinations, making existing patches of vulnerability for the virus to flow within those pockets.
Noshki, located near Afghanistan's border, and Lakki Marwat have also recently reported some positive environmental samples that confirm the virus is present here, said a local reference laboratory official. Samples of latest cases are currently under genetic sequencing for checking spread of virus and origin.
As the threat of polio continues to grow, Pakistan has vowed to mount a nationwide campaign against it beginning from October 28. With the zeal to tackle the menace in the most effective manner, over 45 million children under the age of five will be vaccinated across the country.
Today, Afghanistan and Pakistan remain one of the few countries where polio has not yet been eradicated. The WHO said the virus remains a potential serious public health threat in areas with low vaccination coverage and weak surveillance.
The country declared itself polio-free since 2014 and has kept the disease on bay almost a decade with very robust vaccination programs; however, two cases of vaccine-derived poliovirus cases reported in recent days from Meghalaya create some amount of doubts over a possible resurgence. Experts observe that in India, despite these detections taking place, strong coverage of vaccination at 90-95% and mandatory surveillance measures keep the risk of this widespread outbreak at bay.
The experts point out, however, that such stable situation in India requires continued surveillance. "Countries like Pakistan and parts of Africa remain at a high risk because vaccination rates in those areas are much lower," Dr. Siddharth, public health expert, said. Vaccination is an indispensable act in order to avoid the spread of this incapacitating disease that manifests most importantly as a nervous system affliction leading to the paralysis of a long period.
With concerted efforts from health authorities, there is hope someday that the scourge of polio will be completely eradicated from the face of the earth and future generations will never suffer from its effects.
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The Ebola outbreak in DR Congo has risen to 1,427 cases, while the death toll has climbed to 440, according to the latest government data.
More than 609 patients are hospitalized in Congo, while many have also recovered. Uganda has so far reported 20 confirmed cases and two deaths. There has also been one case in France and another in a US citizen medically evacuated to Germany, both believed to have been imported from areas affected by the ongoing outbreak.
The Ebola virus disease, caused by the Bundibugyo strain, has no approved vaccine or treatment.
"Even without approved therapeutics, people are recovering from this disease, but, of course, we could save many more lives with safe and effective therapeutics in our toolkit," said Dr Tedros Adhanom Ghebreyesus, WHO Director-General.
He said this while announcing the launch of the clinical trial of two therapeutics, with the enrolment of the first patient.
"The PARTNERS trial will evaluate the monoclonal antibody MBP134 and the antiviral drug remdesivir, alone and in combination," he added.
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The study is being coordinated by the DRC's National Institute for Biomedical Research, supported by a coalition of partners including WHO, and conducted in close cooperation with the affected communities.
According to Tedros, patients who enroll in the trial will receive comprehensive supportive care and close follow-up.
"We are also working to ensure they have access to the two drugs should they prove safe and efficacious in the trial."
In addition, the WHO has granted emergency use listing to the first molecular diagnostic test for Bundibugyo virus.
Further, the antiviral drug remdesivir, marketed as Veklury is also expected to start. Remdesivir became widely known during the COVID-19 pandemic and is being evaluated to determine whether it can improve outcomes when combined with the antibody treatment.
As per experts, it could take months, and possibly as many as 1,000 study participants, to determine whether either drug works.
Currently, the study is being offered only at one Ebola treatment center in Congo's Ituri province. The region has been heavily affected by violence, including attacks on healthcare workers responding to a virus spread through contact with infected patients' bodily fluids. Officials plan to expand the trial to other locations once it is safe to do so.
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Tedros said that despite the progress, significant challenges remain, including mistrust and violence.
This week, an Ebola treatment center in Ituri province was attacked, resulting in the deaths of two people. The center was set on fire, and patients fled.
Such acts not only endanger patients and health workers but also impede efforts to stop transmission and save lives.
He added that the complexity of the outbreak requires close coordination across the United Nations system.
Ebola is a severe and often fatal viral hemorrhagic fever first identified in 1976. Since then, more than 30 outbreaks have been recorded, primarily in Central and West Africa.
Common Symptoms of Ebola
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Amid increasing conversations about Donald Trump suffering from dementia, the US President posted an AI-generated video of himself as a doctor diagnosing celebrities with what he calls "Trump Derangement Syndrome (TDS)."
The clip features AI recreations of Hollywood actors and celebrities, including Whoopi Goldberg, Robert De Niro, Julia Roberts and Rosie O'Donnell, all of whom have previously criticized Trump.
"Have you or someone you know been diagnosed with TDS?" the AI Trump asks at the start of the clip posted on Truth Social.
Calling the "symptoms relentless," the 80-year-old President said that "fortunately, I'm Doctor Trump, and I have a treatment plan," The Independent reported.
The AI-generated Trump then invited viewers to hear from some of his "patients."
"I couldn't eat, I couldn't sleep, constantly angry…" the fake De Niro said. "I made everyone miserable around me."
"I feel like I've aged 20 years in the last two years," added the AI version of Roberts, claiming that she was starting to "worry about her future."
The fake O'Donnell claimed that she had been "suffering for over a decade," while the AI Goldberg said she believed she was a "lost cause."
Other stars spoofed in the 90-second clip include actors Edward Norton and John Leguizamo, both of whom have criticized the president.
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At the end of the video, "Doctor Trump" revealed his "treatment" plan: "Turn off fake news."
He further instructed the AI patients to: "Say your prayers and, if you ever feel anxious, just have a Diet Coke like me and you're gonna see a remarkable difference in your life."
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Trump has often labeled his detractors as having Trump Derangement Syndrome, even claiming in the Oval Office that he had heard it "actually is a disease."
The term is an adaptation of "Bush Derangement Syndrome," which was coined by columnist Charles Krauthammer in 2003.
Krauthammer described the term as "the acute onset of paranoia in otherwise normal people in reaction to the policies, the presidency—nay—the very existence of George W. Bush."
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Trump, who became the oldest US president in history after turning 80 this year, has faced growing public scrutiny over his health.
Recent public appearances have prompted speculation after observers noted swollen ankles, bruising on his hands, verbal slips and occasional episodes in which he appeared drowsy during meetings and international summits.
Some physicians have also publicly expressed concerns about the president's physical and cognitive health, although none have diagnosed him with dementia.
But Trump has repeatedly rejected allegations of cognitive decline or other serious health issues. His most recent annual physical examination also concluded him to be "in excellent health."
The White House also maintains that: "President Trump is the sharpest and most accessible President in American history who is working nonstop to solve problems and deliver on his promises."
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The US Centers for Disease Control and Prevention (CDC) has reported another norovirus outbreak aboard a Cruise ship that has sickened nearly 125 people.
So far this year, the CDC has reported seven outbreaks on cruise ships under its jurisdiction, five of which were caused by norovirus.
The outbreak occurred aboard the Ruby Princess during a 20-day voyage along the west coast of North America.
According to the CDC, 102 passengers and 23 crew members reported gastrointestinal illness during the voyage.
The outbreak was first reported to the CDC's Vessel Sanitation Program on June 28.
The Ruby Princess was carrying more than 3,000 passengers and 1,144 crew members during the outbreak.
According to the CDC, Princess Cruises and the ship's crew implemented increased cleaning and disinfection procedures under the company's outbreak prevention and response plan.
Crew members also collected stool specimens from affected individuals for testing, isolated ill passengers and crew members, and consulted with the CDC's Vessel Sanitation Program.
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Norovirus is a highly contagious virus that causes gastroenteritis, leading to inflammation of the stomach and intestines.
Speaking to HealthandMe, epidemiologist Dr. Amitav Banerjee, professor at DY Patil Vidyapeeth, Pune, described norovirus as “notorious because it spreads very fast.”
“It can spread through fomites like handles and knobs, and even a very low infectious dose—around 18 viral particles—can cause infection. So it spreads very fast,” he said.
He added that while many common disinfectants are ineffective against it, norovirus can be inactivated using bleach and chlorine-based cleaning agents.
Although outbreaks can look alarming, Dr. Banerjee emphasized that norovirus infections are generally self-limiting.
“In the ship, it can be managed with oral rehydration, and in severe cases, IV fluids can help prevent complications and mortality,” he said.
Dr. Banerjee also clarified that, unlike diseases with pandemic potential, norovirus outbreaks—while explosive in nature—do not typically pose a long-term global threat.
"Norovirus is a stomach infection contracted through the consumption of contaminated food or water or through contact with an infected individual. The infection is highly contagious, but not life-threatening, and is manageable with proper care and hydration," Dr Suresh Kumar D, Senior Specialist - Infectious Diseases, Apollo Speciality Hospitals, Vanagaram, Chennai, told HealthandMe.
Dr. Banerjee noted that extreme age groups, especially very young infants and the elderly, are at higher risk due to dehydration from diarrheal illness. However, deaths remain rare when proper care is provided.
Norovirus illnesses usually last between two and three days. Symptoms usually begin suddenly within 12 to 48 hours of exposure and may include:
Because of how fast viruses spread, experts highly recommend preventive actions such as:
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