Pakistan continues to be dealing with a polio outbreak as four fresh cases have emerged, pushing the national tally to 37 this year, according to health officials on October 19, 2024. Health officials said that the regional reference laboratory for polio eradication at the National Institute of Health in Islamabad confirmed wild poliovirus type-1 (WPV1) in two children-one from each Balochistan and Khyber-Pakhtunkhwa.

In recent cases, a girl has been affected from Pishin, and two boys from Chaman and Noshki of Balochistan, and a girl from Lakki Marwat in KP. These are the first detections of the virus within Noshki and Lakki Marwat this year; isolated cases of poliovirus were previously reported within Chaman and Pishin. The province of Balochistan was the worst hit with 20 cases, Sindh had 10, Khyber Pakhtunkhwa had five, and Punjab and Islamabad had one case each.

A gigantic fight against polio has been on going in Pakistan- especially in Balochistan and southern KP-over the last two years. Immunisation campaigns have often been suspended or delayed because of local protests, insecurity, and community boycotts. Consequently, quite a number of children did not get the necessary vaccinations, making existing patches of vulnerability for the virus to flow within those pockets.

Noshki, located near Afghanistan's border, and Lakki Marwat have also recently reported some positive environmental samples that confirm the virus is present here, said a local reference laboratory official. Samples of latest cases are currently under genetic sequencing for checking spread of virus and origin.

As the threat of polio continues to grow, Pakistan has vowed to mount a nationwide campaign against it beginning from October 28. With the zeal to tackle the menace in the most effective manner, over 45 million children under the age of five will be vaccinated across the country.

Today, Afghanistan and Pakistan remain one of the few countries where polio has not yet been eradicated. The WHO said the virus remains a potential serious public health threat in areas with low vaccination coverage and weak surveillance.

India On Alert Against Polio

The country declared itself polio-free since 2014 and has kept the disease on bay almost a decade with very robust vaccination programs; however, two cases of vaccine-derived poliovirus cases reported in recent days from Meghalaya create some amount of doubts over a possible resurgence. Experts observe that in India, despite these detections taking place, strong coverage of vaccination at 90-95% and mandatory surveillance measures keep the risk of this widespread outbreak at bay.

The experts point out, however, that such stable situation in India requires continued surveillance. "Countries like Pakistan and parts of Africa remain at a high risk because vaccination rates in those areas are much lower," Dr. Siddharth, public health expert, said. Vaccination is an indispensable act in order to avoid the spread of this incapacitating disease that manifests most importantly as a nervous system affliction leading to the paralysis of a long period.

With concerted efforts from health authorities, there is hope someday that the scourge of polio will be completely eradicated from the face of the earth and future generations will never suffer from its effects.

Nigeria is witnessing an outbreak of cholera, and to curb the spread of the disease, the police there have ordered sanitation measures in the northeastern state of Borno. According to the local media and authorities, about 39 people have died due to the waterborne disease. Local authorities have also reported at least 4,204 cases of infection.

According to the local health authorities, the outbreak is spreading in the Borno capital, Maiduguri, and the surrounding Jere district. The state police commissioner "has directed the full enforcement of the monthly environmental sanitation exercise." The statement added, "Residents are therefore urged to actively participate in the exercise by cleaning their homes, business premises, drainage channels, and surrounding environments."

He added, "To ensure compliance, police personnel and other relevant stakeholders will be deployed to strategic locations across the state during the sanitation period."

The nation is very cautious about the outbreak and has taken several steps to contain the disease as much as possible. The state government has set dedicated treatment centers for public convenience. Notably, cholera is spread by bacteria-tainted water and food, which can easily cause dehydration and diarrhoea.

The advent of modern sewerage systems has eradicated diseases throughout the modern world. Though war, conflict, and social unrest in nations like Nigeria and Sudan result in these unfortunate outbreaks, which take thousands of lives and affect many families.

As Ebola is spreading in African nations of the Democratic Republic of the Congo (DRC) and Uganda, another breakout of Cholera in Nigeria is showing the vulnerabilities of how rampant it is in Africa.

What Is Cholera?

According to the Centers for Disease Control and Prevention (CDC), it is caused by the bacterium Vibrio cholerae. This can be transmitted through drinking water or eating food that contains the bacteria. While most people who get cholera don't get sick, it can cause life-threatening diarrhea and vomiting.

CDC notes that each year, 1.3 to 4 million people around the world get cholera. Among them, 21,000 to 143,000 people die.

What Are The Common Symptoms?

The common symptoms include:

• watery diarrhea
• vomiting
• leg cramps
• losing body fluids
• dehydration and shock

Usually, people develop symptoms within 1 to 10 days of consuming the bacteria.

Who Is At More Risk?

People who live in areas with unsafe drinking water, poor sanitation, and inadequate hygiene are at the highest risk of getting cholera. The disease can spread quickly in areas where sewage and drinking water are not adequately treated. It can also live in brackish water, which is slightly salty, or in coastal water. Thus, eating raw shellfish can also cause cholera.

COVID-19, a name that can trigger a plethora of bad memories and constant fear, a time of solitude and captivity. Though now a breakthrough in medical science connected with coronavirus is giving hope to the possible prevention of Ebola. The universal vaccine was designed entirely by artificial intelligence (AI), and more importantly, it was successful.

It was the first time an AI-designed vaccine has completed a human clinical trial. The results of the trials were published in the Journal of Infection, and according to that report, phase one of the trial was observed by 39 healthy adult volunteers aged 18 to 50 and demonstrated a 100 pc safety profile.

The study stated that this vaccine was developed by the research team at the University of Cambridge and the company DIOSynVax, and they claimed that their vaccine has strong immune responses against various coronavirus strains.

And with this very crucial discovery in medical science, there is also a hope for designing a very effective vaccine for Ebola. Essentially, offering a proactive shield against a disease that continues to pose a significant global public health risk.

How Will This Breakthrough Contribute To The Development Of An Ebola Vaccine?

The vaccines that are traditional often tend to be reactive in nature, which means they can only work on a particular strain of a virus, and as a result, when the virus mutates and evolves, it becomes obsolete.

Artificial intelligence or machine learning can make a big difference in this aspect as it scans the genetic sequences of an entire family of viruses. The development of a universal COVID vaccine followed the same process. The AI pointed out the core features common to all of them, including strains that haven't even crossed over to humans yet, and after that, it has designed the new vaccine.

Though this very vaccine will not directly work on Ebola, the same process and technology can be used to create a similar vaccine in record time for Ebola as well. As the situation of the disease worsens by the day, it has crossed 500 cases.

As of Saturday, the Democratic Republic of the Congo (DRC) reported that its total number of Ebola cases had increased to 488 from 452 cases and caused 86 deaths. Its neighbor, Uganda, also has reported 19 cases.

This time, the Ebola outbreak has caused most harm to the Democratic Republic of the Congo (DRC), and during this mayhem, its neighboring nation, Uganda, which is also fighting to contain the disease as it is also seeing a surge in cases, has completely closed off its western border with DRC.

The World Health Organization (WHO) has declared the outbreak an international public health emergency, and the Centers for Disease Control and Prevention (CDC) warned that the Ebola outbreak of this time could swell to become the largest Ebola epidemic in history.

The situation regarding the outbreak of Ebola is nowhere near slowing down, and the World Health Organization (WHO) said that this outbreak of Ebola is far from under control. The outbreak of the disease in eastern Democratic Republic of the Congo (DRC) and neighboring Uganda has already reached the 500 mark.

On Saturday, the Democratic Republic of the Congo (DRC) reported that its total number of Ebola cases had increased to 488 from 452 cases and caused 86 deaths. Its neighbor, Uganda, also has reported 19 cases.

This time the Ebola outbreak has caused most harm to the Democratic Republic of the Congo (DRC) and during this mayhem its neighboring nation Uganda which is also fighting to contain the disease as it is also seeing surge in cases thus it has completely closed off its western border with DRC.

The worsening condition of the situation is clear, as the global health monitoring organization, the World Health Organization (WHO), has already declared the outbreak an international public health emergency.

And it's not only the case with WHO, another big name in public health, but the United States' Centers for Disease Control and Prevention (CDC) warned that the Ebola outbreak of this time could swell to become the largest Ebola epidemic to date, and is likely to rival the 2014-2016 epidemic in West Africa.

The patient number is still growing as the disease is spreading, and this spread is very hard to contain without an approved vaccine. Though work on the vaccine is in full swing, research on three different vaccines for the Bundibugyo strain of Ebola still needs time, even after being set to be fast-tracked for trials.

What Is Ebola?

Ebola is a severe and deadly disease caused by a virus mostly found in Africa. The spread of the disease happens through contact with infected body fluids.

Some symptoms can indicate a possible infection. This includes fever, headache, weakness, vomiting, diarrhea, muscle pain, sore throat, and unexplained bleeding. This eventually leads to severe complications like bleeding, organ failure, and death.

Ebola is a highly lethal viral hemorrhagic fever first identified in 1976. Over the past five decades, it has caused over 30 outbreaks, primarily in Central and West Africa. The virus takes its name from the Ebola River in the Democratic Republic of the Congo (DRC).

Three strains of the virus — Ebola virus, Sudan virus, and Bundibugyo virus — have caused the largest outbreaks in Africa. Among them, the Ebola virus is considered the deadliest, with fatality rates reaching up to 90% without treatment.

These viruses have repeatedly emerged from animal reservoirs and infected humans in African countries. In the Democratic Republic of the Congo alone, this marks the 17th Ebola outbreak and the third linked to the Bundibugyo strain.