“I'm not great at the advice. Can I interest you in a sarcastic comment?”

This is what ‘Friends’ actor Matthew Perry’s character Chandler Bing was known for. He was known for being funny. However, he had his own struggles in his personal life and those struggles were acute depression. He was treating it with ketamine infusion therapy which is legal in the US and the UK.

What is Ketamine infusion therapy?

Ketamine is an anaesthetic used to treat depression, anxiety and pain under supervised and controlled medical settings. However, it does have its side effects, which can lead to distortion of sight, sound and time. It can also produce calming and relaxing effects.

Ketamine increases a person’s heart rate and blood pressure. If overdosed, it can leave users confused and agitated and can cause them to hurt themselves without even realising it. It can also lead to liver damage and bladder problems.

However, when used in moderation and under the supervision of medical doctors, it can treat depression where traditional antidepressants have failed.

Prof Rupert McShane, a University of Oxford psychiatrist who runs an NHS ketamine treatment clinic told BBC that ketamine “probably turns off the area of the brain that is involved in disappointment.”

Can Ketamine Infusion Therapy Kill Someone?

In simple terms, it cannot, be if the dosage is given in a controlled setting and as prescribed. Ketamine infusion therapy uses drugs in small doses than those used for anaesthesia. It acts faster than traditional anti-depressants, but the effects also wear off way quickly. Which is why it is important to monitor patients’ mental state for relapsing back into depression and discouraging them from overdosing on it.

There are ways of giving people ketamine. One of the ways is through “infusing”, which means to use an IV drip. However, injections, nasal sprays and capsules are also methods used to give people ketamine.

Since the dosage of ketamine used in the infusion treatment is small, it being the reason of actor Perry’s death was ruled out. The medical examiner also noted that Perry’s last ketamine infusion therapy session happened more than a week before his death, which means by the time he had died, it must have worn off.

So, What Happened To Perry?

Though Perry’s last session was more than a week before, his post-mortem showed that his blood contained a high concentration of ketamine. He had died of the “acute effects” of ketamine.

If it was not his session, then how did he get ketamine?

Prosecutors alleged that his assistant gave him at least 27 shots of ketamine in four days before his death, reported BBC.

Perry has been open about his personal struggles and this is what the doctors and dealers used against him. Martin Estrada, the US attorney for California’s Central District told the BBC that people took advantage of his condition. They charged him 165 times more than what vials of ketamine cost.

Names that have come up include Dr Salvador Plasencia, drug dealers “Ketamine Queen” aka Jasveen Sangha and Eric Fleming, and Perry’s live-in assistant Kenneth Iwamasa.

Who Are These Names And What Did They Do?

Ketamine Queen or Sangha supplied drugs that led to Perry’s death. Her home was a “drug-selling emporium,” said Estrada. More than 80 vials of ketamine, and thousands of pills including methamphetamine, cocaine and Xanax were allegedly found in her house known as the “Sangha Stash House.”

Sangha is known to deal with high-end celebs and was a “major source of supply for ketamine to others as well as Perry,” said Estrada.

Dr Plasencia called Perry a “moron” while charging him $2,000 for vials that cost only $12. He sold Perry 20 vials of ketamine between September and October 2023, costing $55,000.

He was the one who taught Iwamasa, who had no medical knowledge to inject the drug. This is after he knew that “Perry’s ketamine addiction was spiralling out of control,” as per what the investigators told the BBC.

Another dealer Fleming was told by Sangha to “delete all our messages.” While Fleming pleaded guilty to conspiring to distribute drugs unlawfully, he also allegedly messaged Sangha: “Please call...Got more info and want to bounce ideas off you. I’m 90% sure everyone is protected. I never dealt with [Perry] only his assistant. So the assistant was the enabler.”

The court documents also revealed that he asked Sangha on whether the ketamine stays in your system or “is it immediately flushed out.”

Dr Pepper, Bots, Cans

The people who allegedly exploited Perry used coded language for ketamine and called it “Dr Pepper”, “bots”, or “cans.”

Selling overpriced drugs, taking advantage of Perry’s mental condition and falsifying medical records to make the drugs given to him look legitimate by Dr Plasencia is what took Perry’s life.

Iwamasa is said to have administered more than 20 shots of ketamine and three on the day Perry died. Whereas ketamine is only administered by a physician. Authorities also found that weeks before Perry’s death, Dr Plasencia allegedly bought 10 vials of ketamine and intended to sell to Perry.

He also injected Perry with a large dose, two days later. This caused him to “freeze up” and spiked his blood pressure.

When I Die, I Want Helping Others To Be The First Thing That’s Mentioned

Perry had always been open about his drug addictions, struggles with alcohol and his depression. He said that his openness would help others who are also struggling and wanted to be remembered by his quote which also is on the homepage of the Mattew Perry Foundation that helps others struggling with the disease of addiction: “When I die, I want helping others to be the first thing that’s mentioned.”

Five arrests have been made in the case so far.

Heart diseases cause the highest number of deaths globally every year, and over the past few years, cardiovascular complications have been noted among youngsters as well. Research has long shown that body fat accumulation can lead to harmful changes to heart structure. This can be potentially deadly later, and the risks were earlier thought to increase in middle age. However, as per Finnish and UK scientists, the most critical age for a spike in the risk of cardiac conditions is 17. Yes, this is when high levels of body fat become potentially harmful to heart health.

Why is 17 a critical age for heart health?

According to experts at the University of Eastern Finland, 17 is a critical age for young people, as adolescents often move towards a more independent life after that. From moving away from home to changes in diet and lifestyle habits, there is a likelihood that many may adopt unhealthy habits like drinking and smoking. This social shift can, over time, result in fat accumulation, thus posing heart disease risks in the future.

On the other hand, experts say that adolescence is the best time to adopt a healthy lifestyle and lower body fat in cases of childhood obesity. It is the best time to reduce the risk of heart disease, thereby increasing the chances of a healthy adulthood.

For this, scientists tracked 1,803 children aged 9–24 years. They used dual-energy X-ray absorptiometry (DXA) scans to evaluate fat levels in the abdomen and body and to calculate muscle mass. The children had the scans completed at the age of nine, and then were tested again at ages 11, 15, 17, and 24 years. Echocardiography scans were also done at 17 and 24 years to examine heart function and structure, as well as insulin, blood sugar, and cholesterol levels.

Researchers found that from the age of 17, excessive fat (abdominal fat specifically) was linked to structural changes in the heart. This can lead to excessive pressure to pump blood normally, thereby contributing to a heightened risk of heart disease later. The results were published in the European Journal of Endocrinology.

The role of fat in changing heart structure

Researchers found that the heart’s structure can be altered by fat, and this happens primarily through inflammation and high blood pressure. Experts concluded that BMI is a poor marker for calculating fat mass in adolescents and children because they have four times more lean mass than fat mass, and BMI does not distinguish between the two. The study helps us understand that accumulated total abdominal and body fat in late adolescence can adversely affect a growing heart. Therefore, any lifestyle changes that can help lower body fat in adolescence, as early as 17 years, can be beneficial.

Fatty liver, or non-alcoholic fatty liver disease (NAFLD), refers to the accumulation of excess fat in liver cells in people who consume little or no alcohol. In its early stages, it may seem harmless. However, it is, in fact, the liver’s first warning that the body’s metabolic balance is burdened. What is concerning is who we are now diagnosing. Young adults in their 20s and early 30s, often with no visible signs of illness, are clear evidence of this condition. This is no longer an additional finding but has become routine. Dr Kandarp Saxena, Gastroenterologist, Manipal Hospital, Jaipur, recently spoke about how fatty liver, which is now becoming more common among younger people, may soon become a lifestyle crisis.

A Lifestyle That Directly Impacts the Liver

Irregular eating habits, such as late-night meals or long gaps followed by overeating, can further throw off the body’s natural metabolic balance. Poor sleep adds another layer, affecting insulin sensitivity and fat metabolism. These are not abstract risks but measurable contributors to how and why fatty liver is developing.

Why Most Young Patients Do Not Realise It

Unlike many other conditions, fatty liver does not produce symptoms that prompt early medical attention. In the early stages, the liver continues to function normally, so daily life goes on as usual. There are no obvious signs to suggest that anything is changing beneath the surface.

Most diagnoses in this age group are incidental, detected during routine blood tests showing mildly elevated liver enzymes or through ultrasound imaging done for unrelated reasons. The absence of these symptoms is not a favourable feature. It delays recognition at a stage when the condition is most easily reversible.

The Indian Risk Profile Is Different

The early onset of fatty liver in India cannot be viewed in the same way as in Western populations. South Asians are known to develop metabolic complications at lower body mass indices. This means that even people who appear healthy or not overweight may still carry harmful fat deep inside the body, along with underlying insulin resistance.

When this is combined with rapid urbanisation, less movement in daily life, and a growing dependence on calorie-dense foods, it slowly adds up to a higher overall risk. As a result, fatty liver is appearing earlier and progressing faster in this population.

From Fat Accumulation to Liver Damage

It is important to understand that fatty liver is not a static condition. In some individuals, simple fat accumulation remains stable. In others, it moves beyond fat build-up and starts irritating the liver, leading to a stage called non-alcoholic steatohepatitis (NASH). This is important because the liver is no longer just holding fat; it is getting damaged.

As the damage continues, the liver tries to heal, but this repair leaves behind scar tissue, known as fibrosis. Over time, this scarring can build up and start to affect how well the liver works. If it continues, it can lead to cirrhosis, where the liver becomes heavily scarred and begins to struggle, increasing the risk of liver failure and cancer. This progression does not happen abruptly; it occurs over years, often without clear clinical warning, making early identification critical.

Why Early Intervention Is Being Missed

Despite being detectable and reversible in its early stages, fatty liver is often not addressed with the urgency it requires. Mild elevations in liver enzymes are sometimes overlooked. Imaging findings are not always followed up with structured intervention. More importantly, younger patients are less likely to be counselled about long-term risk. There is also a tendency to delay action because the condition does not immediately affect quality of life. This delay allows progression that could otherwise have been prevented.

Treatment Exists—but Depends on Behaviour

There is no single drug that reverses fatty liver in the way lifestyle modification does. Clinical evidence consistently shows that sustained weight reduction, regular physical activity, and dietary changes can significantly reduce liver fat and, in some cases, reverse early damage. However, these interventions require consistency. Short-term efforts do not produce lasting benefit. Without sustained change, the underlying process continues.

A Shift That Needs Recognition

The increasing prevalence of fatty liver in young Indians is not an isolated clinical observation; it reflects a shift in how disease is presented. When a condition that was once seen later in life starts appearing a decade or two earlier, it changes the health trajectory of an entire population. It raises the chances of long-term complications and means people end up living with the disease for much longer. Fatty liver is now emerging as one of the earliest indicators of this shift.

Fatty liver does not begin with symptoms. It begins with accumulation of excess calories, reduced activity, and sustained metabolic imbalance. By the time it is detected, the process is already in motion. The challenge, therefore, is not just in treating the condition but in recognising it early enough to change its course.

The President of the United States of America, Donald Trump, is making headlines again—and not for the best reasons. In a recent picture that is now going viral on X (formerly Twitter), Trump is seen standing with his feet spread wider than shoulder-width apart. In the image, he appears to form an “upside-down V-shape," while his arms are stiffly positioned at his sides. The photograph has sparked a storm on social media, with users questioning why the 79-year-old is standing this way—is it due to a loss of coordination or a consequence of ageing? Some netizens have also speculated that Trump could be relying on a hidden support device, such as leg or hip braces.

Can ageing have an impact on posture?

Remember when teachers at school used to ask you to sit up straight and correct your posture? It turns out that a seemingly innocent slouch can, over the years, lead to a hunched back that is difficult to reverse. However, poor posture can also be a consequence of ageing. Ideally, one should be able to stand upright comfortably. But over time, the spine can develop a permanent curve, resembling a question mark. This condition is known as kyphosis, or, in simpler terms, a hunched back. Minor changes in posture are normal with ageing; however, it is still advisable to consult a doctor if noticeable posture changes occur.

Complications linked to a hunched back

With kyphosis, most people experience mild discomfort. However, other symptoms may include:

1. Balance issues
2. Breathing difficulties
3. Inability to perform daily tasks

How poor posture can cause pain

Poor posture can trigger pain anywhere in the body—from the neck to the ankles. When joint mechanics are affected, it can lead to dysfunction across the body, much like a kinetic chain reaction. Age-related posture problems can impact the discs that act as cushions between the vertebrae, as well as the muscles supporting the spine.

Ageing can, over time, lead to a loss of bone mass due to calcium deficiency. Bones may become less dense and shrink slightly, increasing the risk of falls and fractures. The discs in the spine may also shrink, causing the vertebrae to move closer together, which can affect movement and flexibility.

Is kyphosis inevitable?

Kyphosis is not necessarily an unavoidable consequence of ageing. Keeping the chest, back, and core muscles strong can help prevent posture-related issues later in life. Therefore, it is advisable to incorporate strength training into your routine and focus equally on the core and shoulders.