“I'm not great at the advice. Can I interest you in a sarcastic comment?”

This is what ‘Friends’ actor Matthew Perry’s character Chandler Bing was known for. He was known for being funny. However, he had his own struggles in his personal life and those struggles were acute depression. He was treating it with ketamine infusion therapy which is legal in the US and the UK.

What is Ketamine infusion therapy?

Ketamine is an anaesthetic used to treat depression, anxiety and pain under supervised and controlled medical settings. However, it does have its side effects, which can lead to distortion of sight, sound and time. It can also produce calming and relaxing effects.

Ketamine increases a person’s heart rate and blood pressure. If overdosed, it can leave users confused and agitated and can cause them to hurt themselves without even realising it. It can also lead to liver damage and bladder problems.

However, when used in moderation and under the supervision of medical doctors, it can treat depression where traditional antidepressants have failed.

Prof Rupert McShane, a University of Oxford psychiatrist who runs an NHS ketamine treatment clinic told BBC that ketamine “probably turns off the area of the brain that is involved in disappointment.”

Can Ketamine Infusion Therapy Kill Someone?

In simple terms, it cannot, be if the dosage is given in a controlled setting and as prescribed. Ketamine infusion therapy uses drugs in small doses than those used for anaesthesia. It acts faster than traditional anti-depressants, but the effects also wear off way quickly. Which is why it is important to monitor patients’ mental state for relapsing back into depression and discouraging them from overdosing on it.

There are ways of giving people ketamine. One of the ways is through “infusing”, which means to use an IV drip. However, injections, nasal sprays and capsules are also methods used to give people ketamine.

Since the dosage of ketamine used in the infusion treatment is small, it being the reason of actor Perry’s death was ruled out. The medical examiner also noted that Perry’s last ketamine infusion therapy session happened more than a week before his death, which means by the time he had died, it must have worn off.

So, What Happened To Perry?

Though Perry’s last session was more than a week before, his post-mortem showed that his blood contained a high concentration of ketamine. He had died of the “acute effects” of ketamine.

If it was not his session, then how did he get ketamine?

Prosecutors alleged that his assistant gave him at least 27 shots of ketamine in four days before his death, reported BBC.

Perry has been open about his personal struggles and this is what the doctors and dealers used against him. Martin Estrada, the US attorney for California’s Central District told the BBC that people took advantage of his condition. They charged him 165 times more than what vials of ketamine cost.

Names that have come up include Dr Salvador Plasencia, drug dealers “Ketamine Queen” aka Jasveen Sangha and Eric Fleming, and Perry’s live-in assistant Kenneth Iwamasa.

Who Are These Names And What Did They Do?

Ketamine Queen or Sangha supplied drugs that led to Perry’s death. Her home was a “drug-selling emporium,” said Estrada. More than 80 vials of ketamine, and thousands of pills including methamphetamine, cocaine and Xanax were allegedly found in her house known as the “Sangha Stash House.”

Sangha is known to deal with high-end celebs and was a “major source of supply for ketamine to others as well as Perry,” said Estrada.

Dr Plasencia called Perry a “moron” while charging him $2,000 for vials that cost only $12. He sold Perry 20 vials of ketamine between September and October 2023, costing $55,000.

He was the one who taught Iwamasa, who had no medical knowledge to inject the drug. This is after he knew that “Perry’s ketamine addiction was spiralling out of control,” as per what the investigators told the BBC.

Another dealer Fleming was told by Sangha to “delete all our messages.” While Fleming pleaded guilty to conspiring to distribute drugs unlawfully, he also allegedly messaged Sangha: “Please call...Got more info and want to bounce ideas off you. I’m 90% sure everyone is protected. I never dealt with [Perry] only his assistant. So the assistant was the enabler.”

The court documents also revealed that he asked Sangha on whether the ketamine stays in your system or “is it immediately flushed out.”

Dr Pepper, Bots, Cans

The people who allegedly exploited Perry used coded language for ketamine and called it “Dr Pepper”, “bots”, or “cans.”

Selling overpriced drugs, taking advantage of Perry’s mental condition and falsifying medical records to make the drugs given to him look legitimate by Dr Plasencia is what took Perry’s life.

Iwamasa is said to have administered more than 20 shots of ketamine and three on the day Perry died. Whereas ketamine is only administered by a physician. Authorities also found that weeks before Perry’s death, Dr Plasencia allegedly bought 10 vials of ketamine and intended to sell to Perry.

He also injected Perry with a large dose, two days later. This caused him to “freeze up” and spiked his blood pressure.

When I Die, I Want Helping Others To Be The First Thing That’s Mentioned

Perry had always been open about his drug addictions, struggles with alcohol and his depression. He said that his openness would help others who are also struggling and wanted to be remembered by his quote which also is on the homepage of the Mattew Perry Foundation that helps others struggling with the disease of addiction: “When I die, I want helping others to be the first thing that’s mentioned.”

Five arrests have been made in the case so far.

The World Health Organization (WHO) has renewed attention on the importance of laboratory biosafety and biosecurity after the death of a worker at a plague research institute in Siberia, Russia. This comes even after Russian authorities confirm that no laboratory accident or confirmed plague infection.

In a Disease Outbreak News update published on October 10, the WHO stated it had not identified evidence of ongoing transmission of pneumonic plague linked to the incident. However, the cause of the worker's fatal pneumonia remains unexplained, leaving several emergency public health questions unanswered.

A 28-year-old lab technician of the Irkutsk Anti-Plague Research Institute who was hospitalised with severe pneumonia on September 29 and died on October 2.

Initial media reports suspected possible pneumonic plague following occupational exposure, but Russian authorities reported that tests had not detected plague or other dangerous pathogens.

WHO's Inquiry

Also read: Plague Treatable, CDC Monitoring US Arrivals From Russia After Worker’s Death, Says Director Erica Schwartz

According to updates provided by Russian authorities, more than 5,500 laboratory tests were conducted as part of the investigation. No high-threat pathogens were detected among high-risk contacts. Additionally, the contacts reportedly displayed no alarming symptoms.

Russia also told the WHO that two independent investigations found no laboratory biosafety or biosecurity incidents at the institute. The authorities classified the death as pneumonia of "undetermined origin" rather than plague.

However, the WHO has highlighted the fact that it has not received information about the confirmed cause of the fatal illness.

In its assessment, the agency stated, "A key uncertainty for this event is the absence of a confirmed diagnosis in the deceased laboratory worker."

The WHO added that the occupational setting remained relevant because the worker was employed at an institution that handled high-risk pathogens. “A laboratory-associated exposure therefore cannot be fully excluded at this stage,” the report said.

This does not establish that an accident occurred. Rather, it points towards the limits of the available evidence while the cause of death remains unresolved.

WHO Reiterates Laboratory Safety Rules

Also read: Russia Denies Second Plague Case As WHO Seeks Answers On Lab Death; Trump Says It’s Not A Bioweapon

The WHO's advice focuses on preventing occupational exposure to hazardous biological agents and reducing the risk of accidental leaks.

The agency emphasised that laboratories handling dangerous pathogens should maintain robust biosafety, biosecurity and infection prevention and control practices. These precautions apply routinely, regardless of whether a particular incident has been confirmed.

The WHO specifically clarified that its recommendation was precautionary and did not imply that a laboratory-related infection or incident had been confirmed yet.

Biosafety involves practices and equipment designed to prevent accidental exposure to infectious pathogens, while biosecurity focuses on preventing their loss, theft, misuse or unauthorised release.

Plague Outbreak Risk

The WHO said it had found no evidence of ongoing transmission associated with the incident. Russian authorities reported no recent plague cases in the Irkutsk region and said medical monitoring of contacts had been completed.

However, the absence of a confirmed diagnosis means the exact cause of the worker's death remains unknown, keeping loose ends open. The WHO said additional clinical, epidemiological and laboratory information would help strengthen its assessment.

Pneumonic plague, the form that initially prompted concern, affects the lungs and can spread between people through infectious respiratory droplets. It can be fatal without prompt treatment, although antibiotics can be effective when administered early.

Veteran actor Sharmila Tagore recently revisited her lung cancer diagnosis after she appeared on Soha Ali Khan's podcast All About Her with Saba Ali Khan. While Saba opened up about her brain tumour, they also discussed Sharmila's lung cancer which was diagnosed at stage zero.

The 81-year-old veteran actor insisted on undergoing surgery despite being diagnosed at stage zero lung cancer. She said that many believed that the procedure might not be necessary. Soha revealed that doctors confirmed that the tissue was malignant during surgery and were able to remove it completely.

Sharmila Tagore did not need chemotherapy after the surgery, according to Soha. In a chat with Nayandeep Rakshit, Soha shared that her mother did not need chemotherapy. "With my mother, she was one of the very few people to be diagnosed with lung cancer at stage zero. No chemotherapy, nothing. It was cut out of her, and she is, touchwood, fine," she said.

The actor's case brings up the question of whether surgery at the earliest stage of lung cancer can prevent the disease from progressing.

What Is Stage Zero Lung Cancer?

Stage zero is the earliest stage of non-small cell lung cancer, also called carcinoma in situ. At this stage, abnormal or cancerous cells are confined to the innermost lining of the airways and have not invaded deeper lung tissue or spread to lymph nodes or distant organs.

Unlike more advanced lung cancers, stage zero disease is often treatable with local treatment alone. However, it can be difficult to detect because it may not cause noticeable symptoms.

Also read: PET-CT in Colon Cancer: When Can It Help?

Can Surgery Stop Lung Cancer From Progressing?

In terms of progression, surgery can often help stage zero lung cancer, provided the abnormal tissue is completely removed and the diagnosis confirms that it has not become invasive.

The objective is to remove the affected tissue before the cancerous cells penetrate deeper into the lung. Depending on the lesion's size and location, surgeons may perform a wedge resection or segmentectomy, removing a small portion of the lung.

For patients whose cancer is confined to the airway lining, chemotherapy or radiation is generally not required after successful surgery, just like in Tagore's case.

Treatment decisions, however, depend on the final pathology report and individual clinical findings.

Also read: Left Delhi To Escape Air Pollution? Why Health Effects May Linger For A Long Time

Stage Zero Lung Cancer Is Difficult To Detect

Lung cancer is frequently diagnosed after it has progressed because early disease may produce fewer or no symptoms. Persistent cough, chest pain and breathlessness are not reliable early warning signs of stage zero disease.

Low-dose CT screening can help detect lung abnormalities before symptoms develop, especially among people at high risk, like certain long-term smokers.

However, screening recommendations depend on age and smoking history, and not every lung abnormality detected on a scan is cancer.

Even though complete removal of stage zero lung cancer can offer an excellent chance of cure, it does not eliminate every future risk.

Patients may need follow-up imaging and clinical assessments to monitor for recurrence or a new primary lung cancer. The risk varies depending on the original tumour, the type of treatment and individual factors.

Flu activity is rising unusually early in parts of the US, UK and Japan, while COVID-19 cases are also increasing in the UK. Health experts are urging eligible people to get vaccinated ahead of winter, when respiratory infections can add to pressure on hospitals.

According to Nature, flu tests are returning positive at unusually high rates for early fall on the US West Coast and in the UK. In Japan, outbreaks in August and early September forced some schools to close as students returned from summer break.

“It would be an incredibly early season” for the US if cases on the West Coast continue rising at their current pace, Scott Hensley, a virologist at the University of Pennsylvania, told Nature. US flu activity typically peaks in December and January.

H1N1 Dominates Flu Cases In The US

Also read: ‘American Covid’ Strain Drives 50% Surge in UK Hospital Admissions: XFG Symptoms to Know

H1N1 accounted for 96% of US flu cases tested for type in the week ending September 26. H3N2 accounted for nearly all the remaining cases, while no influenza B was detected, Nature reported, citing federal data.

The Centers for Disease Control and Prevention (CDC) classified the 2025–2026 US flu season as moderately severe, with more than 32 million cases, 390,000 hospitalizations and up to 81,000 deaths. Cases rose in November and peaked in December.

This season, flu activity began rising in August and September in western states, including California, Washington, Alaska and Hawaii.

“We’re looking at an early flu season this year,” James Watt, deputy director of infectious diseases at the California Department of Public Health, said at an October 6 briefing, according to the San Francisco Chronicle.

Danielle Zerr, an infectious diseases specialist at Seattle Children’s, told The Washington Post that the early spread was concerning because many people had yet to be vaccinated.

“The way flu is circulating now, you wanted that vaccine in you two weeks ago, if not even a little before that,” she said.

UK Reports Flu And COVID-19

Read More: XFG COVID Variant: What India Should Watch As Cases Rise In UK And France

In the UK, around 6.5% of flu tests were positive in the week reported by the UK Health Security Agency (UKHSA), up from 5% the previous week. This compares with 3.3% at the same point last year.The early rise has raised concerns that flu could add to pressure on the National Health Service (NHS), which has already experienced a busy summer. University students returning to campuses may also be contributing to the spread.

COVID-19 activity has increased as well. Reported infections rose from 1,374 in August to 4,589 in September, the highest monthly total since October last year, according to figures cited in reports. However, officials said levels of both infections remained within the expected range.

Frankie Swords, national medical director at NHS England, warned of early signs of winter pressure on hospitals. Around two in every 100,000 people in England were being hospitalized with flu, while overall hospital capacity was approximately 95% occupied in September.

Swords urged eligible people to get vaccinated early, warning that pressure could increase as temperatures fall.

Since the start of September, around 3.9 million people in the UK had received a flu vaccine, while approximately 730,000 had received an autumn COVID-19 vaccine.

France is also reporting a rise in COVID-19 cases as the government prepares to launch its autumn COVID and flu vaccination campaign on October 13.

Flu Symptoms You Should Know

Flu often begins suddenly, causing fever, chills, body aches and extreme fatigue.

Common symptoms include:

• Fever and chills
• Body aches
• Extreme fatigue
• Headache
• Sore throat
• Runny or stuffy nose
• Cough

Children may also experience vomiting and diarrhea. Flu symptoms can overlap with those of other respiratory infections, so testing may be needed to confirm the cause.

Do Flu Vaccines Protect Against All Circulating Strains?

Seasonal flu vaccines are designed to protect against selected influenza strains, including H1N1, H3N2 and influenza B viruses.

However, influenza viruses can undergo genetic changes known as antigenic drift, which may reduce vaccine effectiveness against circulating strains.

Flu and COVID-19 vaccines target different viruses. A flu shot does not protect against COVID-19, so eligible people may need separate vaccinations to reduce their risk of severe illness from both infections.