“I'm not great at the advice. Can I interest you in a sarcastic comment?”

This is what ‘Friends’ actor Matthew Perry’s character Chandler Bing was known for. He was known for being funny. However, he had his own struggles in his personal life and those struggles were acute depression. He was treating it with ketamine infusion therapy which is legal in the US and the UK.

What is Ketamine infusion therapy?

Ketamine is an anaesthetic used to treat depression, anxiety and pain under supervised and controlled medical settings. However, it does have its side effects, which can lead to distortion of sight, sound and time. It can also produce calming and relaxing effects.

Ketamine increases a person’s heart rate and blood pressure. If overdosed, it can leave users confused and agitated and can cause them to hurt themselves without even realising it. It can also lead to liver damage and bladder problems.

However, when used in moderation and under the supervision of medical doctors, it can treat depression where traditional antidepressants have failed.

Prof Rupert McShane, a University of Oxford psychiatrist who runs an NHS ketamine treatment clinic told BBC that ketamine “probably turns off the area of the brain that is involved in disappointment.”

Can Ketamine Infusion Therapy Kill Someone?

In simple terms, it cannot, be if the dosage is given in a controlled setting and as prescribed. Ketamine infusion therapy uses drugs in small doses than those used for anaesthesia. It acts faster than traditional anti-depressants, but the effects also wear off way quickly. Which is why it is important to monitor patients’ mental state for relapsing back into depression and discouraging them from overdosing on it.

There are ways of giving people ketamine. One of the ways is through “infusing”, which means to use an IV drip. However, injections, nasal sprays and capsules are also methods used to give people ketamine.

Since the dosage of ketamine used in the infusion treatment is small, it being the reason of actor Perry’s death was ruled out. The medical examiner also noted that Perry’s last ketamine infusion therapy session happened more than a week before his death, which means by the time he had died, it must have worn off.

So, What Happened To Perry?

Though Perry’s last session was more than a week before, his post-mortem showed that his blood contained a high concentration of ketamine. He had died of the “acute effects” of ketamine.

If it was not his session, then how did he get ketamine?

Prosecutors alleged that his assistant gave him at least 27 shots of ketamine in four days before his death, reported BBC.

Perry has been open about his personal struggles and this is what the doctors and dealers used against him. Martin Estrada, the US attorney for California’s Central District told the BBC that people took advantage of his condition. They charged him 165 times more than what vials of ketamine cost.

Names that have come up include Dr Salvador Plasencia, drug dealers “Ketamine Queen” aka Jasveen Sangha and Eric Fleming, and Perry’s live-in assistant Kenneth Iwamasa.

Who Are These Names And What Did They Do?

Ketamine Queen or Sangha supplied drugs that led to Perry’s death. Her home was a “drug-selling emporium,” said Estrada. More than 80 vials of ketamine, and thousands of pills including methamphetamine, cocaine and Xanax were allegedly found in her house known as the “Sangha Stash House.”

Sangha is known to deal with high-end celebs and was a “major source of supply for ketamine to others as well as Perry,” said Estrada.

Dr Plasencia called Perry a “moron” while charging him $2,000 for vials that cost only $12. He sold Perry 20 vials of ketamine between September and October 2023, costing $55,000.

He was the one who taught Iwamasa, who had no medical knowledge to inject the drug. This is after he knew that “Perry’s ketamine addiction was spiralling out of control,” as per what the investigators told the BBC.

Another dealer Fleming was told by Sangha to “delete all our messages.” While Fleming pleaded guilty to conspiring to distribute drugs unlawfully, he also allegedly messaged Sangha: “Please call...Got more info and want to bounce ideas off you. I’m 90% sure everyone is protected. I never dealt with [Perry] only his assistant. So the assistant was the enabler.”

The court documents also revealed that he asked Sangha on whether the ketamine stays in your system or “is it immediately flushed out.”

Dr Pepper, Bots, Cans

The people who allegedly exploited Perry used coded language for ketamine and called it “Dr Pepper”, “bots”, or “cans.”

Selling overpriced drugs, taking advantage of Perry’s mental condition and falsifying medical records to make the drugs given to him look legitimate by Dr Plasencia is what took Perry’s life.

Iwamasa is said to have administered more than 20 shots of ketamine and three on the day Perry died. Whereas ketamine is only administered by a physician. Authorities also found that weeks before Perry’s death, Dr Plasencia allegedly bought 10 vials of ketamine and intended to sell to Perry.

He also injected Perry with a large dose, two days later. This caused him to “freeze up” and spiked his blood pressure.

When I Die, I Want Helping Others To Be The First Thing That’s Mentioned

Perry had always been open about his drug addictions, struggles with alcohol and his depression. He said that his openness would help others who are also struggling and wanted to be remembered by his quote which also is on the homepage of the Mattew Perry Foundation that helps others struggling with the disease of addiction: “When I die, I want helping others to be the first thing that’s mentioned.”

Five arrests have been made in the case so far.

More than six years after the COVID-19 pandemic devastated the world, newly released personal journals of former National Institute of Allergy and Infectious Diseases (NIAID) Director Dr. Anthony Fauci are giving a raw glimpse into the behind-the-scenes discussions, scientific uncertainty, and political tensions that clouded United States' pandemic response.

The 1,141-page collection, released by Senator Rand Paul ahead of Fauci's scheduled Senate testimony, chronicles events from December 2019 through December 2022.

Announcing the release of Fauci's journals, Sen. Rand Paul said, "The American people deserve the truth about what happened during the COVID-19 pandemic. Dr. Fauci's own contemporaneous writings provide an unprecedented window into the decisions, discussions, and uncertainties that shaped the federal response."

The journals have reignited debate over the origins of SARS-CoV-2 and Fauci's role during one of the most challenging public health crises of recent times.

However, experts say that the diaries represent Fauci's personal contemporaneous notes and do not conclusively establish the origin of COVID-19.

Major COVID-related Revelations From Dr Anthony Fauci's Diary

Uncertainty About COVID-19's Origin

One of the biggest revelations is that Anthony Fauci recorded discussions in late January 2020 in which several scientists raised questions about whether SARS-CoV-2 could have originated from a laboratory because of certain genetic features.

The diary shows these possibilities were discussed internally before scientists later concluded that natural spillover was the more likely. The diary does not provide proof that the virus leaked from a lab.

Fauci wrote, "The first infection was in early December and was not connected to the market... Now we know the market was not the source, it was the amplifier. Having said that, somewhere the virus jumped from animals to humans."

Also read: Trump Should Take A Month Off For His Health, Says Bill O'Reilly

The Lab Leak

The entries reveal Fauci continued receiving updates about the virus's origin while publicly emphasizing the available scientific evidence supporting natural emergence.

After a conference call with leading virologists, Fauci wrote that several experts discussed whether part of the virus genome could have evolved naturally. He listed the participants and summarized the debate over the possibility of a laboratory origin.

COVID-19 Initially Viewed As Severe Influenza

Early diary entries describe the outbreak as looking similar to "bad influenza" before severe complications became clear. This reflects the limited knowledge available in January and early February 2020.

School Closures

Fauci's notes reportedly show he was conflicted about balancing infection control against the educational and mental health consequences of prolonged school closures, highlighting the uncertainty policymakers faced.

Also read: Ebola Outbreak in DR Congo Nears 3,000 Cases, 1,300 Deaths as UN Warns Virus Is 'Spreading Like Wildfire'

Internal Frustration

The diary documents Fauci's concerns about bureaucratic delays, operational problems, and disagreements within the federal government during the early COVID-19 response, suggesting these challenges complicated public health decision-making.

Overshadowing President Donald Trump

The entries describe Fauci's dynamic with President Donald Trump, disagreements over masks, hydroxychloroquine, and public messaging, and concerns about how politics affected science.

He wrote, "AMAZING interaction with POTUS... It was a disturbingly rambling discussion since he kept talking about TV ratings, and HC (Hydroxychloroquine), and influenza and virtually everything else as I was trying to keep him on track."

He also wrote about outshining President Trump. "Apparently the WH is very upset that I am being profiled and it looks like I am putting down the POTUS and becoming a star that outshines him. ... Very stressful!!"

He also wrote that Trump praised him. "As usual, POTUS was very warm and friendly with me... 'I love you, Tony. I feel like giving you a big hug.'"

Media Attention

The journals reveal Fauci's obsession with his fame due to widespread media coverage and his efforts to maintain public trust. He wrote, "For better or worse, I am becoming an international celebrity. Calls from all over the world."

He added, "WH press conference picked up by many outlets. Many print profiles and features on me. Ridiculous, too numerous to count! ... Press is going wild with me."

Fauci's diary sparked a lot of responses from politicians and health experts.

He said, "He lied about masks. He lied about social distancing. He lied about transmission. He lied about natural immunity. He lied about the vaccine's capacity to prevent infection."

He added. "Dr. Fauci did incalculable damage to public health and to the public's trust in government. "He prioritized getting on TV over protecting public health."

Olympic hurdler and bobsledder Lolo Jones has revealed that she suffered a debilitating spinal injury during bobsled training, lost bladder control, and was allegedly denied timely medical care, raising serious concerns about athlete health and safety within the U.S. Olympic system.

Jones shared her experience after reports of the the events surrounding a training accident ahead of the 2025 IBSF World Championships in Lake Placid surfaced.

According to the reports, she sustained a severe lower back injury while testing a new bobsled but continued competing because her condition was never diagnosed at the time.

What Happened?

During the training session, Lolo Jones experienced symptoms like intense lower back pain, numbness, leg weakness, foot drop, and loss of bladder control; all of which can be warning signs of cauda equina syndrome, a rare but serious condition caused by compression of nerves at the base of the spinal cord.

It is a medical emergency as delayed treatment can result in permanent paralysis or loss of bladder and bowel function.

Despite these symptoms, Jones alleges she did not receive urgent medical evaluation. Reports claim that when she visited the U.S. Olympic Training Center's sports medicine clinic seeking treatment, her scheduled massage appointment had been canceled, and she was not provided immediate imaging such as an MRI or X-ray.

Convinced she was dealing with a painful but manageable injury, Jones continued to compete in the World Championships, completing multiple high-speed bobsled runs. She later said that had the sled crashed during competition, she could have been left permanently paralysed.

After returning home, Jones reportedly paid for her own MRI, which revealed the extent of the damage. The scan showed a herniated disc, additional disc bulges, and tears involving the L3, L4 and L5 levels of her spine, with leaking spinal fluid. She subsequently underwent spinal surgery at her own expense.

Jones also claims that after surgery she was denied access to training and rehabilitation facilities at the Olympic Training Center, forcing her to fund her own recovery, rehabilitation, travel and training. According to reports, the financial burden exceeded $100,000.

The athlete has since called for greater accountability and reforms in athlete medical care, especially who compete in the Olympics.

In a public statement, Jones wrote that she had "never even been given an X-ray or an MRI" despite her symptoms and said she wanted to help ensure other athletes do not face similar situations.

Also read: Teenage Powerlifting Champion Dies At 17, After 600lb Barbell Falls On Neck- What Went Wrong And How Could It Have Been Prevented?

Early Detection Is Essential

Experts consider loss of bladder control, leg weakness, numbness around the saddle area, and severe lower back pain to be serious symptoms that need immediate emergency assessment.

Prompt diagnosis, usually with an MRI, and urgent surgery when cauda equina syndrome is confirmed can significantly improve the chances of preserving nerve function and preventing the risk of paralysis.

Jones is one of the few athletes to have competed at both the Summer and Winter Olympics, representing the United States in hurdles and bobsled.

Her latest allegations have sparked renewed discussion about whether elite athletes receive timely access to appropriate medical attention when serious injuries occur.

Amid raging wildfires, France is preparing for its fourth major heatwave of the year as extreme temperatures and bone-dry conditions in the southwest intensify the challenges faced by crews battling a massive wildfire in the Bordeaux region.

Temperatures in Bordeaux were expected to reach 33°C (91°F) during the day, around 7°C above the average high recorded between 1961 and 1990, according to the Reuters Climate Monitor.

"The situation we are dealing with today is the most severe we have ever recorded, the toughest since the Second World War," said President Emmanuel Macron.

Firefighters managed to contain the blaze overnight, but the situation remained difficult, with reports suggesting the wildfire threat could continue until November.

France is experiencing an unprecedented wildfire season, with the area affected by fires already surpassing the previous record set in 2022. Around 4000 more people were evacuated from tourist sites along the Atlantic coast, following the evacuation of more than 250,000 people earlier.

UK Faces Fourth Heatwave As Temperatures Rise

Also read: Europe Swelters Under Heatwave And Wildfires; 360,000+ Evacuated: What Are The Health Risks?

Meanwhile, the UK is also preparing for its fourth heatwave of the summer, with temperatures expected to climb to 34°C in parts of the country later this week.

Several amber and yellow heat alerts have been issued as the UK Health Security Agency (UKHSA) warned that rising temperatures could increase health risks, particularly for vulnerable groups.

Temperatures are forecast to reach 29°C in southeast England on Tuesday before rising further to 34°C on Wednesday.

Dry Conditions Raise Wildfire And Drought Concerns

Read More: Could Wildfire Smoke Trigger Your Migraine? Latest Study Finds A Strong Link

The heatwave follows an exceptionally hot and dry June, which has left some of the UK’s driest regions without rainfall for weeks. Forecasters have warned that parts of southern and southeast England could face “exceptionally severe” wildfire conditions this week due to extreme heat and prolonged dry weather.

Parts of Wales have already been placed under drought status, while large areas of England remain under “prolonged dry weather” status — the final stage before a drought declaration.

What Happens When Medicines Get Too Hot?

According to the Medicines and Healthcare products Regulatory Agency (MHRA), high temperatures can affect medicines and reduce how well they work.

Rising temperatures can affect how some medicines work in the body, posing potential risks for people with long-term health conditions. Experts say simple precautions can help prevent heat-related complications.

Medicines that do not require refrigeration, including tablets, inhalers, hormone replacement therapy (HRT) patches, and epinephrine, should generally be stored in a cool, dry place at room temperature, ideally between 15°C and 25°C. This is because high temperatures can reduce the potency and effectiveness of the active ingredients in medicines.

Alison Cave, Chief Safety Officer at the MHRA, said that when there’s a heatwave, medicines left in the heat – in cars, bags, or on sunny windowsills – might not work properly when you need them.

“Some medicines can also make you more likely to burn in the sun, feel dizzy, or get dehydrated, especially if you’re taking diuretics or have a condition like asthma, heart disease, or diabetes.”

To stay safe during hot weather, the MHRA advised people to:

• Store medicines in a cool, dry place away from direct sunlight, especially when travelling or spending time outdoors.
• Stay hydrated, recognise signs of heat-related illness, and listen to your body.
• Take extra precautions in the sun if medicines increase sensitivity to sunlight and raise the risk of burns.