“I'm not great at the advice. Can I interest you in a sarcastic comment?”

This is what ‘Friends’ actor Matthew Perry’s character Chandler Bing was known for. He was known for being funny. However, he had his own struggles in his personal life and those struggles were acute depression. He was treating it with ketamine infusion therapy which is legal in the US and the UK.

What is Ketamine infusion therapy?

Ketamine is an anaesthetic used to treat depression, anxiety and pain under supervised and controlled medical settings. However, it does have its side effects, which can lead to distortion of sight, sound and time. It can also produce calming and relaxing effects.

Ketamine increases a person’s heart rate and blood pressure. If overdosed, it can leave users confused and agitated and can cause them to hurt themselves without even realising it. It can also lead to liver damage and bladder problems.

However, when used in moderation and under the supervision of medical doctors, it can treat depression where traditional antidepressants have failed.

Prof Rupert McShane, a University of Oxford psychiatrist who runs an NHS ketamine treatment clinic told BBC that ketamine “probably turns off the area of the brain that is involved in disappointment.”

Can Ketamine Infusion Therapy Kill Someone?

In simple terms, it cannot, be if the dosage is given in a controlled setting and as prescribed. Ketamine infusion therapy uses drugs in small doses than those used for anaesthesia. It acts faster than traditional anti-depressants, but the effects also wear off way quickly. Which is why it is important to monitor patients’ mental state for relapsing back into depression and discouraging them from overdosing on it.

There are ways of giving people ketamine. One of the ways is through “infusing”, which means to use an IV drip. However, injections, nasal sprays and capsules are also methods used to give people ketamine.

Since the dosage of ketamine used in the infusion treatment is small, it being the reason of actor Perry’s death was ruled out. The medical examiner also noted that Perry’s last ketamine infusion therapy session happened more than a week before his death, which means by the time he had died, it must have worn off.

So, What Happened To Perry?

Though Perry’s last session was more than a week before, his post-mortem showed that his blood contained a high concentration of ketamine. He had died of the “acute effects” of ketamine.

If it was not his session, then how did he get ketamine?

Prosecutors alleged that his assistant gave him at least 27 shots of ketamine in four days before his death, reported BBC.

Perry has been open about his personal struggles and this is what the doctors and dealers used against him. Martin Estrada, the US attorney for California’s Central District told the BBC that people took advantage of his condition. They charged him 165 times more than what vials of ketamine cost.

Names that have come up include Dr Salvador Plasencia, drug dealers “Ketamine Queen” aka Jasveen Sangha and Eric Fleming, and Perry’s live-in assistant Kenneth Iwamasa.

Who Are These Names And What Did They Do?

Ketamine Queen or Sangha supplied drugs that led to Perry’s death. Her home was a “drug-selling emporium,” said Estrada. More than 80 vials of ketamine, and thousands of pills including methamphetamine, cocaine and Xanax were allegedly found in her house known as the “Sangha Stash House.”

Sangha is known to deal with high-end celebs and was a “major source of supply for ketamine to others as well as Perry,” said Estrada.

Dr Plasencia called Perry a “moron” while charging him $2,000 for vials that cost only $12. He sold Perry 20 vials of ketamine between September and October 2023, costing $55,000.

He was the one who taught Iwamasa, who had no medical knowledge to inject the drug. This is after he knew that “Perry’s ketamine addiction was spiralling out of control,” as per what the investigators told the BBC.

Another dealer Fleming was told by Sangha to “delete all our messages.” While Fleming pleaded guilty to conspiring to distribute drugs unlawfully, he also allegedly messaged Sangha: “Please call...Got more info and want to bounce ideas off you. I’m 90% sure everyone is protected. I never dealt with [Perry] only his assistant. So the assistant was the enabler.”

The court documents also revealed that he asked Sangha on whether the ketamine stays in your system or “is it immediately flushed out.”

Dr Pepper, Bots, Cans

The people who allegedly exploited Perry used coded language for ketamine and called it “Dr Pepper”, “bots”, or “cans.”

Selling overpriced drugs, taking advantage of Perry’s mental condition and falsifying medical records to make the drugs given to him look legitimate by Dr Plasencia is what took Perry’s life.

Iwamasa is said to have administered more than 20 shots of ketamine and three on the day Perry died. Whereas ketamine is only administered by a physician. Authorities also found that weeks before Perry’s death, Dr Plasencia allegedly bought 10 vials of ketamine and intended to sell to Perry.

He also injected Perry with a large dose, two days later. This caused him to “freeze up” and spiked his blood pressure.

When I Die, I Want Helping Others To Be The First Thing That’s Mentioned

Perry had always been open about his drug addictions, struggles with alcohol and his depression. He said that his openness would help others who are also struggling and wanted to be remembered by his quote which also is on the homepage of the Mattew Perry Foundation that helps others struggling with the disease of addiction: “When I die, I want helping others to be the first thing that’s mentioned.”

Five arrests have been made in the case so far.

"So, I am in New Delhi, India, and the air quality is over 750. It is the equivalent of smoking 18 cigarettes a day," says Alex, a British travel vlogger in a video uploaded seven days ago on Instagram. He calls the current situation in health a public health emergency. In the video, he walks around the city wearing an N-95 mask and says, "It is super sad. I cannot even see 50 meters in front of me. That is how bad the air quality is in Delhi."

Read: Breathing Delhi's Toxic Air Is Like Smoking 20 Cigarettes A Day, According To Pulmonologist

As of Monday 7am, the city's average AQI remains under the "very poor" category, with the reading of 366 as per the Central Pollution Control Board (CPCB). Seven areas slip under the 'severe' zone, with Narela recording the worst AQI of 418.

As per the CPCB, AQI between 0 to 50 is good, 51 to 100 is satisfactory, 101 to 200 is moderate, 201 to 300 is poor, 301 to 400 is very poor and 401 to 500 is severe.

Impact Of Toxic Air On Its Population

Not just Delhi, but several other metro cities too have recorded a worsening in its air quality levels, in this backdrop, a Lancet study revealed that due to long-term air pollution exposure in India, every year, 1.5 million deaths occur. The study noted that every 10μg/m³ increase in annual PM2·5 concentration was associated with an 8.6 pc higher risk of all-cause mortality.

Using India’s National Ambient Air Quality Standards, researchers estimate that about 3.8 million deaths between 2009 and 2019 were linked to PM2.5 exposure. When WHO guidelines were applied, the number rose sharply to 16.6 million, nearly one-fourth of all deaths in the country. The analysis relied on advanced causal methods and high-resolution models that mapped district-level PM2.5 exposure across India, while accounting for factors such as socioeconomic status, age distribution, and indoor air pollution.

Also Read: 'No Direct Link Between Lung Disease And Air Pollution,' Says Minister; But Studies Say Something Else

These findings are backed by a 2017 time-series study from Delhi that examined the short-term impact of air pollution on deaths from natural causes. The researchers pointed out that studies worldwide have consistently shown a clear link between common urban air pollutants and harmful health effects. Despite Delhi’s well-documented air quality crisis, they noted that limited local evidence on how specific pollutants affect health had long slowed meaningful policy action.

Furthermore, several other studies also reveal the impact of toxic air on different organs of the body, including lungs causing respiratory illness, as well as increasing the risk of dysmenorrhea in women.

A study published in Frontiers in Public Health, explored the data of 2,96,078 women and girls between the age of 16 to 55 years in Taiwan and correlated it with the long-term air pollution data between 2000 and 2013. None of these women had any history of dysmenorrhea before the survey had began.

Another 2017 study titled Pulmonary Health Effects of Air Pollution, it is clear that lung cancer could be exacerbated due to exposure to a variety of environmental air pollutants with greatest effects due to particulate matter (PM), ozone, and nitrogen oxides.

Delhi's Toxic Air Should Concern All

As of now, the air that we breathe in Delhi contains the same chemicals that are present in a cigarette. These chemicals include carbon monoxide, benzene, cadmium, formaldehyde, and benzopyrene.

Flu cases in the US has touched almost the 5 million mark, as per the latest data from the Centers for Disease Control and Prevention (CDC). New York City has seen the highest levels of flu-like activity, revealed the data. Among the other states are Alabama, Colorado, Connecticut, Hawaii, Louisiana, Maryland, Minnesota, New Hampshire, New Jersey, Ohio, Rhode Island, and Texas. All these states noted a "moderate" level of flu-like or respiratory illnesses, while rest of the states remain in "low" or "very low" levels of flu-like activities.

What Does The CDC Data Reveal In Flu Cases?

As per the CDC data, there have been at least 4.6 million illnesses, with 49,000 hospitalization, and 1,900 deaths so far by flu in this season. These cases of flu are linked with the new variant known as the subclade K. CDC notes that among the samples sent to it, of the over 900 of them, 0-% were A(H3N2), of those that had further testing, nearly 90% of them were subclade K.

The CDC also notes that this mutant is a mismatch from the season's flu vaccine composition, however, according to experts the vaccine is still useful as the first line of defense against flu, including to avoid any severe illness, hospitalization, and or death.

John Brownstein, an epidemiologist told the ABC News, "Even with this new variant and some mismatch with the vaccine, getting a flu shot is still absolutely worth it. The vaccine continues to provide strong protection against severe outcomes like hospitalization and death, and that’s especially important as flu activity ramps up."

Flu Deaths In Children

Two pediatric flu deaths were reported this week, which brought the total number three to this season. Last season, there were 288, the same as the number in 2009 during the H1N1 pandemic, It is the highest levels since 2004. It was in that year when flu child deaths became mandatory for states to report to CDC.

The CDC found that about 90% of children who died from flu last season were not vaccination. The CDC study found that flu vaccination among kids have dropped 10% points lower than the pre-pandemic levels, with about only 40% of children getting the flu shot this season.

As of now, around 140 million doses of flu have been distributed, whereas last year, it was 128 million. The CDC also notes that anyone over the age of 6 months must get their annual flu shot. It is never too late to get the vaccine, note the experts.

Brownstein also notes: "This is the time of year when flu typically starts to take off, and we expect activity to continue increasing in the weeks ahead. As people gather indoors and travel more around the holidays, those conditions can accelerate spread."

H3N2 Symptoms

• High fever (often above 101°F)
• Severe body aches and muscle pain
• Extreme tiredness that lasts longer
• Dry cough that can be persistent
• Headache
• Sore throat
• Runny or stuffy nose
• Loss of appetite
• Nausea (especially in children)

The recovery time of any influenza could last up to 5 to 14 days, the key is to monitor breathing patterns and avoid over medication.

Donald Trump’s health has long been under scrutiny, and a recent Instagram post by a physical therapist, @epistemiccrisis, who holds a doctorate and has 14 years of experience treating dementia patients, has stirred fresh speculation. The doctor discussed how tertiary stage syphilis, also known as neurosyphilis, can closely mimic the symptoms of behavioural variant frontotemporal dementia.

What Is Tertiary Stage Syphilis?

Tertiary syphilis is the late stage of a syphilis infection, and it is relatively uncommon, usually appearing years or even decades after the initial infection. Its manifestations can vary, but the most common forms include cardiovascular syphilis, central nervous system involvement—classically presenting as tabes dorsalis or general paresis—and gummatous syphilis, which most often affects the liver. In the United States, syphilis is considered a reportable illness, meaning cases must be reported to public health authorities.

Tertiary Stage Syphilis And The Brain

Tertiary stage syphilis occurs when the infection remains untreated for years, potentially causing serious neurological complications. Before antibiotics were widely available, neurosyphilis accounted for roughly 15% of psychiatric inpatients, as per the doctor. The disease can damage the frontal and temporal lobes, producing behavioural changes strikingly similar to dementia.

Case Study Explains The Symptom Overlap

The doctor referenced a PubMed case study of a 47-year-old male whose behaviour drastically changed, leading to psychiatric admission. The patient showed extreme disorientation and poor hygiene, including rubbing his own faeces in his hair. After receiving antibiotics, his symptoms resolved, and brain scans later revealed improved blood flow to the frontal lobe.

Could Donald Trump Have Tertiary Stage Syphilis?

Red marks on Trump’s hands have sparked discussion about possible tertiary stage syphilis. However, the doctor noted that untreated syphilis in someone of Trump’s age would generally produce more severe complications, making the likelihood low. Additional health factors, including possible history of stroke, heart issues, and kidney disease, further complicate speculation.

Are Frontotemporal Dementia and Tertiary Syphilis Related?

Donald Trump has been speculated to show signs of frontotemporal dementia, a condition affecting behavior, personality, and decision-making. Interestingly, tertiary stage syphilis, specifically neurosyphilis, can cause similar symptoms by damaging the frontal and temporal lobes. Both conditions may lead to changes in social behavior, judgment, and cognitive function, making it challenging to differentiate without proper medical evaluation. Unlike frontotemporal dementia, which is progressive and currently incurable, tertiary syphilis is treatable with antibiotics, underscoring the need for accurate diagnosis.

Is Tertiary Stage Syphilis Treatable?

Neurosyphilis is treatable with antibiotics, and early detection is critical. The case study highlights how the condition can mimic dementia, emphasizing the need for careful evaluation—even for high-profile figures like Donald Trump.

Disclaimer: The claims discussed in this article are being made by the Instagram user @epistemiccrisis. Health & Me does not verify or endorse these claims, and this content is intended for informational purposes only, not as a medical diagnosis or advice.