“I'm not great at the advice. Can I interest you in a sarcastic comment?”

This is what ‘Friends’ actor Matthew Perry’s character Chandler Bing was known for. He was known for being funny. However, he had his own struggles in his personal life and those struggles were acute depression. He was treating it with ketamine infusion therapy which is legal in the US and the UK.

What is Ketamine infusion therapy?

Ketamine is an anaesthetic used to treat depression, anxiety and pain under supervised and controlled medical settings. However, it does have its side effects, which can lead to distortion of sight, sound and time. It can also produce calming and relaxing effects.

Ketamine increases a person’s heart rate and blood pressure. If overdosed, it can leave users confused and agitated and can cause them to hurt themselves without even realising it. It can also lead to liver damage and bladder problems.

However, when used in moderation and under the supervision of medical doctors, it can treat depression where traditional antidepressants have failed.

Prof Rupert McShane, a University of Oxford psychiatrist who runs an NHS ketamine treatment clinic told BBC that ketamine “probably turns off the area of the brain that is involved in disappointment.”

Can Ketamine Infusion Therapy Kill Someone?

In simple terms, it cannot, be if the dosage is given in a controlled setting and as prescribed. Ketamine infusion therapy uses drugs in small doses than those used for anaesthesia. It acts faster than traditional anti-depressants, but the effects also wear off way quickly. Which is why it is important to monitor patients’ mental state for relapsing back into depression and discouraging them from overdosing on it.

There are ways of giving people ketamine. One of the ways is through “infusing”, which means to use an IV drip. However, injections, nasal sprays and capsules are also methods used to give people ketamine.

Since the dosage of ketamine used in the infusion treatment is small, it being the reason of actor Perry’s death was ruled out. The medical examiner also noted that Perry’s last ketamine infusion therapy session happened more than a week before his death, which means by the time he had died, it must have worn off.

So, What Happened To Perry?

Though Perry’s last session was more than a week before, his post-mortem showed that his blood contained a high concentration of ketamine. He had died of the “acute effects” of ketamine.

If it was not his session, then how did he get ketamine?

Prosecutors alleged that his assistant gave him at least 27 shots of ketamine in four days before his death, reported BBC.

Perry has been open about his personal struggles and this is what the doctors and dealers used against him. Martin Estrada, the US attorney for California’s Central District told the BBC that people took advantage of his condition. They charged him 165 times more than what vials of ketamine cost.

Names that have come up include Dr Salvador Plasencia, drug dealers “Ketamine Queen” aka Jasveen Sangha and Eric Fleming, and Perry’s live-in assistant Kenneth Iwamasa.

Who Are These Names And What Did They Do?

Ketamine Queen or Sangha supplied drugs that led to Perry’s death. Her home was a “drug-selling emporium,” said Estrada. More than 80 vials of ketamine, and thousands of pills including methamphetamine, cocaine and Xanax were allegedly found in her house known as the “Sangha Stash House.”

Sangha is known to deal with high-end celebs and was a “major source of supply for ketamine to others as well as Perry,” said Estrada.

Dr Plasencia called Perry a “moron” while charging him $2,000 for vials that cost only $12. He sold Perry 20 vials of ketamine between September and October 2023, costing $55,000.

He was the one who taught Iwamasa, who had no medical knowledge to inject the drug. This is after he knew that “Perry’s ketamine addiction was spiralling out of control,” as per what the investigators told the BBC.

Another dealer Fleming was told by Sangha to “delete all our messages.” While Fleming pleaded guilty to conspiring to distribute drugs unlawfully, he also allegedly messaged Sangha: “Please call...Got more info and want to bounce ideas off you. I’m 90% sure everyone is protected. I never dealt with [Perry] only his assistant. So the assistant was the enabler.”

The court documents also revealed that he asked Sangha on whether the ketamine stays in your system or “is it immediately flushed out.”

Dr Pepper, Bots, Cans

The people who allegedly exploited Perry used coded language for ketamine and called it “Dr Pepper”, “bots”, or “cans.”

Selling overpriced drugs, taking advantage of Perry’s mental condition and falsifying medical records to make the drugs given to him look legitimate by Dr Plasencia is what took Perry’s life.

Iwamasa is said to have administered more than 20 shots of ketamine and three on the day Perry died. Whereas ketamine is only administered by a physician. Authorities also found that weeks before Perry’s death, Dr Plasencia allegedly bought 10 vials of ketamine and intended to sell to Perry.

He also injected Perry with a large dose, two days later. This caused him to “freeze up” and spiked his blood pressure.

When I Die, I Want Helping Others To Be The First Thing That’s Mentioned

Perry had always been open about his drug addictions, struggles with alcohol and his depression. He said that his openness would help others who are also struggling and wanted to be remembered by his quote which also is on the homepage of the Mattew Perry Foundation that helps others struggling with the disease of addiction: “When I die, I want helping others to be the first thing that’s mentioned.”

Five arrests have been made in the case so far.

A whopping $600 million global vaccine aid meant for poorer nations has been put on hold by US Health Secretary Robert F. Kennedy Jr., according to a media report.

The delay in vaccines is putting pressure on the international humanitarian group Gavi, the Vaccine Alliance that distributes them, Politico reported.

Gavi noted that it has not received the funds due for the current and previous fiscal years, which account for about 15 percent of its budget.

The funds are set to expire on September 30 if the Trump administration does not release them.

The organization provides vaccines for 20 diseases, including measles, malaria and polio, to more than 50 low-income countries worldwide.

Sania Nishtar, Gavi CEO, told the newswire AFP, the funding gap, combined with reductions from other donors, has particularly impacted malaria vaccination efforts.

Gavi has delivered 39 million doses of a malaria vaccine to 25 African countries, where the disease predominantly affects children under five. Nishtar warned that tens of thousands of children could die as a result of the funding cuts.

Why Is Kennedy Holding Up Vaccines

Kennedy argues that the shots are obsolete with dangerous ingredients that the US has long since phased out.

“Gavi has refused to provide the United States with the specific data, studies, or detailed accounting of how US funds are used,” Emily Hilliard, senior press secretary at the Health and Human Services Department, said in a statement.

Advocates for Gavi, the Vaccine Alliance warn that withholding funds could cost children’s lives. They argue that the vaccines used are safe and better suited for developing regions, where refrigeration is limited and administering booster doses is more difficult.

Hilliard said Gavi has declined to create a plan to phase out thimerosal, a mercury-based vaccine preservative that Kennedy believes may be linked to autism. The administration has asked Gavi to stop using vaccines containing this preservative.

Thimerosal is used in several vaccines distributed by Gavi, including combination shots protecting against multiple diseases, according to former chief executive Seth Berkley. He explained that many developing countries rely on multi-dose vials, which require less refrigeration but may contain thimerosal to prevent contamination.

Without such vaccines, “kids would go without vaccines… and that would lead directly to deaths,” Berkley said.

During testimony before the Senate Appropriations Committee, Kennedy also raised concerns about a vaccine used to protect against diphtheria, tetanus and pertussis, claiming it had been discontinued in the US due to safety issues.

Gavi responded that the vaccine remains in use because it offers longer-lasting protection and requires fewer doses. The organization said the vaccine “is safe and effective and estimated to have saved 40 million lives in the past 50 years,” the report said.

A plant-based diet is highly recommended for a healthy heart — weight watchers can also benefit from it, as can diabetics. When one goes vegan, the biggest change comes when one moves from dairy milk to oat, almond, or soy milk. Parents, too, are now shifting their children to trendy vegan milk options — little do they realise that this could bring their worst fears to life. According to the British Society for Allergy & Clinical Immunology, drinks that are aimed at children and often marketed as healthy are usually loaded with sugar and offer little or no nutrition.

Why has plant milk become a preferred choice?

Experts found that children under five years of age are more prone to malnutrition, tooth decay, or even obesity. The study is the first of its kind, and its warning will be published in the coming week. It is backed by the British Dental Association and the British Dietetic Association. Doctors say that plant-based drinks are often compared to cow’s milk in terms of nutrition. However, these claims are not supported by current evidence.

Why is plant milk discouraged for children?

Plant milk has gained popularity in recent years because of the health benefits that many believe it offers. While adults may benefit from it in several ways, toddlers must not be given these packaged, sugary drinks. The added sugars can become nothing more than a frequent treat for children, who may lose their milk teeth sooner and suffer from decay. Researchers found that families are often convinced that plant milk is good for children, but these oat, almond, and soy versions of milk are processed and full of sucrose and fructose syrups.

According to a report, most of these drinks contain large amounts of sugar in the form of maltodextrin, glucose syrup, sucrose, and fructose. A 350 ml glass of such milk contains more than double a toddler’s daily sugar allowance. Ideally, toddlers should not be given more than 14 grams of sugar every day. Their young bodies can struggle to absorb vitamin B12 and calcium from plant drinks. The BSACI recommends that parents opt for unsweetened, fortified plant milk instead, as these can play a crucial role in supporting children’s health.

How do ultra-processed foods affect children’s health?

Ultra-processed foods (UPFs) are defined as food groups that undergo a great deal of processing — the most natural foods fall under Group 1, while heavily processed foods are placed under Group 4. While these do not definitively determine how healthy a food option is, they indicate the level of processing involved. Highly processed foods are associated with a range of health problems, which is why it is important to make informed dietary choices.

What are minimally processed foods?

In your kitchen, foods with a minimal level of processing include:

1. Fruits
2. Vegetables
3. Grains
4. Legumes
5. Meat and poultry
6. Eggs
7. Fish and seafood
8. Fresh milk
9. Spices and herbs
10. Coffee and tea
11. Nuts and seeds
12. Plain yoghurt

What are ultra-processed foods in your kitchen?

Some of the most processed foods in your kitchen include:

1. Sweetened yoghurt
2. Soft drinks
3. Biscuits
4. Breakfast cereals
5. Candies
6. Cake mixes
7. Breads and buns
8. Energy drinks
9. Energy bars
10. Frozen foods — pies, pizzas, snacks, sausages, pepperoni, ham, and salami
11. Instant foods — noodles, soups, and sauces

Breast cancer is the most common type of cancer reported among women living in metropolitan India. And while the causes have largely been genetic or linked to family history, a new study says that a woman's breast tissue undergoes dramatic changes with age, creating an environment where cancer cells are more likely to flourish. Researchers at the University of Cambridge in the UK and the University of British Columbia in Canada mapped how breast tissue changes over time. Comprising over three million cells, the map tracks how breast tissue undergoes changes in women as they age. It was found that the most striking shift occurs around menopause.

How does age influence breast changes in women?

Researchers found that as women age, their breast tissue undergoes changes. During the 20s, these changes can be attributed to pregnancy and childbirth. However, the major and most dramatic changes occur around menopause. With age, the number of cells in breast tissue declines. As a result, the structure of the tissue also changes. This creates favourable conditions in which cancer cells can thrive and survive more easily, thereby explaining why breast cancer risk increases with age.

Researchers also identified a cluster of cell types in the breast tissue. As per the American Cancer Society, 320,000 women in the US might be diagnosed with breast cancer this year, making it the most common type of tumour in women. Breast cancer rates are also rising in younger women for unclear reasons, but most cases are still diagnosed in women aged 50 years and above. Age is an important risk factor for nearly all types of cancer. Researchers say that this is partly because people accumulate genetic mutations in their cells with age. As a result, abnormal cells spread uncontrollably and develop into tumours.

Why is age a risk factor for breast cancer?

Experts say that despite the rising incidence of breast cancer, it is not well understood how breast tissue changes with age and contributes to cancer risk. To investigate this, experts analysed normal breast tissue samples from 527 women aged 15–86 years who were undergoing breast reduction surgery. Using advanced imaging, experts mapped individual cells in a two-dimensional representation of how breast tissue changes over time.

The map also found that breast tissue divides less often with age, and the number of immune cells declines. The number of epithelial cells that line the milk-producing structures and mammary ducts also declines with age. However, the scale of changes across the breast is surprising.

Why does breast structure change with age?

Researchers found that the structure of breast tissue also changes with age. The milk-producing lobules shrink, blood vessels decrease, and fat cells increase. Stromal and immune cells also move away from epithelial cells, thereby making it easier for cancer cells to spread and escape. Younger breasts also have relatively more immune cells, known as active T-cells and B-cells, that can identify and destroy tumour cells before they multiply.

Older breasts have fewer cancer-fighting cells and immune cells that other studies implicate in cancer development. These changes create an inflammatory environment in which the immune system is less able to hold back cancer cells and is more permissive of carcinogenesis. However, it is unclear why certain types of cells change.

The age when breast cancer risk peaks

Researchers found that ageing peaks in the late 40s, corresponding to menopause. After this, depending on how quickly the breast tissue ages, one could be more prone to breast cancer risk. The study, however, did not analyse genetics and other breast cancer-influencing risk factors. Previous studies suggest that normal breast tissue in women with genetic risk factors in place ages faster than in others.

The research was published in the Nature Aging journal.