“I'm not great at the advice. Can I interest you in a sarcastic comment?”

This is what ‘Friends’ actor Matthew Perry’s character Chandler Bing was known for. He was known for being funny. However, he had his own struggles in his personal life and those struggles were acute depression. He was treating it with ketamine infusion therapy which is legal in the US and the UK.

What is Ketamine infusion therapy?

Ketamine is an anaesthetic used to treat depression, anxiety and pain under supervised and controlled medical settings. However, it does have its side effects, which can lead to distortion of sight, sound and time. It can also produce calming and relaxing effects.

Ketamine increases a person’s heart rate and blood pressure. If overdosed, it can leave users confused and agitated and can cause them to hurt themselves without even realising it. It can also lead to liver damage and bladder problems.

However, when used in moderation and under the supervision of medical doctors, it can treat depression where traditional antidepressants have failed.

Prof Rupert McShane, a University of Oxford psychiatrist who runs an NHS ketamine treatment clinic told BBC that ketamine “probably turns off the area of the brain that is involved in disappointment.”

Can Ketamine Infusion Therapy Kill Someone?

In simple terms, it cannot, be if the dosage is given in a controlled setting and as prescribed. Ketamine infusion therapy uses drugs in small doses than those used for anaesthesia. It acts faster than traditional anti-depressants, but the effects also wear off way quickly. Which is why it is important to monitor patients’ mental state for relapsing back into depression and discouraging them from overdosing on it.

There are ways of giving people ketamine. One of the ways is through “infusing”, which means to use an IV drip. However, injections, nasal sprays and capsules are also methods used to give people ketamine.

Since the dosage of ketamine used in the infusion treatment is small, it being the reason of actor Perry’s death was ruled out. The medical examiner also noted that Perry’s last ketamine infusion therapy session happened more than a week before his death, which means by the time he had died, it must have worn off.

So, What Happened To Perry?

Though Perry’s last session was more than a week before, his post-mortem showed that his blood contained a high concentration of ketamine. He had died of the “acute effects” of ketamine.

If it was not his session, then how did he get ketamine?

Prosecutors alleged that his assistant gave him at least 27 shots of ketamine in four days before his death, reported BBC.

Perry has been open about his personal struggles and this is what the doctors and dealers used against him. Martin Estrada, the US attorney for California’s Central District told the BBC that people took advantage of his condition. They charged him 165 times more than what vials of ketamine cost.

Names that have come up include Dr Salvador Plasencia, drug dealers “Ketamine Queen” aka Jasveen Sangha and Eric Fleming, and Perry’s live-in assistant Kenneth Iwamasa.

Who Are These Names And What Did They Do?

Ketamine Queen or Sangha supplied drugs that led to Perry’s death. Her home was a “drug-selling emporium,” said Estrada. More than 80 vials of ketamine, and thousands of pills including methamphetamine, cocaine and Xanax were allegedly found in her house known as the “Sangha Stash House.”

Sangha is known to deal with high-end celebs and was a “major source of supply for ketamine to others as well as Perry,” said Estrada.

Dr Plasencia called Perry a “moron” while charging him $2,000 for vials that cost only $12. He sold Perry 20 vials of ketamine between September and October 2023, costing $55,000.

He was the one who taught Iwamasa, who had no medical knowledge to inject the drug. This is after he knew that “Perry’s ketamine addiction was spiralling out of control,” as per what the investigators told the BBC.

Another dealer Fleming was told by Sangha to “delete all our messages.” While Fleming pleaded guilty to conspiring to distribute drugs unlawfully, he also allegedly messaged Sangha: “Please call...Got more info and want to bounce ideas off you. I’m 90% sure everyone is protected. I never dealt with [Perry] only his assistant. So the assistant was the enabler.”

The court documents also revealed that he asked Sangha on whether the ketamine stays in your system or “is it immediately flushed out.”

Dr Pepper, Bots, Cans

The people who allegedly exploited Perry used coded language for ketamine and called it “Dr Pepper”, “bots”, or “cans.”

Selling overpriced drugs, taking advantage of Perry’s mental condition and falsifying medical records to make the drugs given to him look legitimate by Dr Plasencia is what took Perry’s life.

Iwamasa is said to have administered more than 20 shots of ketamine and three on the day Perry died. Whereas ketamine is only administered by a physician. Authorities also found that weeks before Perry’s death, Dr Plasencia allegedly bought 10 vials of ketamine and intended to sell to Perry.

He also injected Perry with a large dose, two days later. This caused him to “freeze up” and spiked his blood pressure.

When I Die, I Want Helping Others To Be The First Thing That’s Mentioned

Perry had always been open about his drug addictions, struggles with alcohol and his depression. He said that his openness would help others who are also struggling and wanted to be remembered by his quote which also is on the homepage of the Mattew Perry Foundation that helps others struggling with the disease of addiction: “When I die, I want helping others to be the first thing that’s mentioned.”

Five arrests have been made in the case so far.

Measles, a highly contagious but vaccine-preventable disease, has claimed another young life. Wisconsin has reported its first measles-related death since 1990, taking the reported US death toll to eight in 2026.

The US, which eliminated sustained domestic measles transmission in 2000, is witnessing a major resurgence. The Centers for Disease Control and Prevention (CDC) reported 4,852 confirmed measles cases as of October 29.

According to state health department reports, the country has recorded eight measles-related deaths this year: six in Pennsylvania, one in New York and one in Wisconsin. At least four involved children or infants.

However, the CDC has not yet updated its website and has confirmed only four measles-associated deaths so far this year.

Childhood vaccination rates have declined in recent years, falling below the 95% coverage generally needed to prevent outbreaks.

Disruptions to routine childhood immunisation during the COVID-19 pandemic, declining vaccination coverage and growing vaccine hesitancy have contributed to the resurgence. Vaccine scepticism has also been amplified by anti-vaccine messaging from the Donald Trump-led administration, including Health and Human Services (HHS) Secretary Robert F. Kennedy Jr.

Also read: Pennsylvania Reports Sixth Measles Death As Outbreak Crosses 1,400 Cases Across 45 Counties

What Happened In The Wisconsin Case?

The Wisconsin Department of Health Services (DHS) reported the death of an infant due to measles, marking the state's first such death since 1990.

The coroner listed measles as the immediate cause of death, according to the official statement. DHS said it would not release additional information to protect the privacy of the child and family.

"It is with a heavy heart we are reporting the first death of an infant connected with a measles outbreak in Wisconsin in many years. My heart is broken for the family," said DHS Secretary Kirsten Johnson.

"Any death of a child is a tragedy and even more so when it is related to a vaccine-preventable disease. Measles can cause serious illness and death, and all Wisconsinites need to evaluate their risk and take steps to protect themselves and their family."

Wisconsin Reports More Than 400 Measles Cases

Also read: EXCLUSIVE: Ex-CDC Vaccine Advisor Says Measles Outbreak Bigger Than Reported, Slams RFK Jr’s ‘No-See Evil’ Approach

As of November 3, Wisconsin had reported 431 measles cases across 13 counties in 2026, the highest number recorded in the state in more than 35 years. Nine people have required hospitalisation due to severe symptoms.

Reported case counts may not reflect the full extent of transmission. Not everyone who develops symptoms seeks medical care or undergoes testing, meaning some infections may go unreported.

Why Are Children At Risk?

Declining childhood vaccination coverage is a major concern. US vaccination rates have fallen below the 95% coverage generally needed to prevent measles outbreaks.

Children younger than five years, pregnant people and those with weakened immune systems are at increased risk of severe complications.

Two doses of the measles, mumps and rubella (MMR) vaccine are approximately 97% effective against measles. Children as young as six months may receive an early dose in certain circumstances, including travel to areas experiencing outbreaks. This early dose does not replace the two routine doses recommended later in childhood.

What Are The Symptoms And Complications Of Measles?

Measles spreads through the air when an infected person coughs or sneezes. The virus can remain infectious in the air or on surfaces for up to two hours.

Initial symptoms include:

• High fever
• Cough
• Runny nose
• Red, watery eyes

A rash usually develops several days later, beginning on the face and spreading down the body.

Although many people recover, measles can cause serious and potentially life-threatening complications, including pneumonia and encephalitis, or inflammation of the brain. The infection can also weaken the immune system, increasing vulnerability to other infections.

The sudden collapse and death of a nine-year-old girl inside her Delhi classroom following a cardiac arrest has raised concerns about sudden cardiac emergencies in children. The Class 3 student reportedly collapsed shortly after returning to the classroom from a games period.

CCTV footage showed her entering the classroom, holding her waist and falling to the floor. A teacher rushed to help her, while school staff took her to a nearby hospital. She was subsequently taken to another hospital in Nirman Vihar, where doctors declared her dead.

Speaking to HealthandMe, Dr Neeraj Awasthy, Senior Director, Pediatric Cardiology, Fortis Hospital, Okhla, said the heart condition in children are extremely rare and differ from those in adults.

"In adults, a heart attack is usually caused by a blockage in the arteries supplying the heart. In children, sudden cardiac arrest is more often associated with an underlying heart condition, such as a structural abnormality, an inherited problem affecting the heart rhythm or inflammation of the heart muscle," he said.

What Causes Sudden Cardiac Events In Children?

Also read: Spanish Striker Jesus De Miguel Dies After On-Field Collision: Can A Blow To The Chest Trigger Cardiac Arrest?

According to Dr Awasthy, sudden cardiac arrest in children is commonly associated with structural heart abnormalities, inherited rhythm disorders and inflammation of the heart muscle.

In a post on X, Dr Sudhir Kumar, Neurologist at Apollo Hospitals, Hyderabad, identified other conditions that can trigger cardiac arrest in apparently healthy children:

• Hypertrophic cardiomyopathy.
• Long QT syndrome.
• Catecholaminergic polymorphic ventricular tachycardia (CPVT).
• Congenital coronary artery abnormalities.
• Myocarditis.

Some children may have no symptoms until a life-threatening cardiac arrhythmia occurs, he noted.

Does Genetics Contribute To Sudden Cardiac Death?

Nearly one in five sudden cardiac deaths in young people may have a definite genetic explanation, according to scientist Vinod Scaria.

In a post on X, he identified three groups of inherited conditions linked to this risk:

• Cardiac channelopathies.
• Cardiomyopathies.
• Familial hypercholesterolaemia.

An analysis of Indian genomes found variants associated with channelopathies in approximately 1% of individuals, cardiomyopathies in more than 1.5% and familial hypercholesterolaemia in about one in 150 individuals, Scaria said.

A molecular autopsy can identify genetic causes that a conventional autopsy may miss. Since many of these conditions are inherited in an autosomal dominant manner, up to half of first-degree relatives could carry the same genetic variant.

People with a family history of unexplained sudden death or inherited heart disease should seek genetic counselling.

What Warning Signs Should Parents Watch For?

Read More: Energy Drinks Linked To More Heart Problems In Young Adults: Study Flags Cardiac Risks

Dr Awasthy and Dr Kumar highlighted the following warning signs:

• Fainting during physical activity.
• Unexplained chest pain.
• Breathlessness.
• A racing heartbeat.

What Should You Do If A Child Suddenly Collapses?

Dr Kumar said immediate cardiopulmonary resuscitation (CPR) and access to an automated external defibrillator (AED) can save a child's life if they collapse and are unresponsive or not breathing normally. He also outlined the steps teachers and bystanders should take:

1. Check responsiveness and breathing: Do this for no more than 10 seconds.
2. Call emergency services: If the child is unresponsive and not breathing normally or is only gasping, call an ambulance.
3. Get an AED: Ask someone to bring one.
4. Start CPR immediately: Do not wait for the ambulance.

For a school-age child, he advised:

• Perform chest compressions at 100–120 per minute.
• Compress the chest approximately 5 cm, or one-third of its depth.
• If trained, give 30 compressions followed by two rescue breaths when performing CPR alone.
• Minimise interruptions.
• Use an AED as soon as available and follow its instructions.

How Can Schools Prepare For Cardiac Emergencies?

Dr Kumar recommended that schools:

• Train all teachers and support staff in CPR and basic life support.
• Make AEDs accessible on campus.
• Establish clear emergency response protocols.
• Ensure staff know how to contact emergency services.
• Conduct regular mock drills.

An experimental gene therapy has shown tremendous potential in reducing the frequency of seizures in three patients with drug-resistant epilepsy.

The results have raised hopes for a new approach to treating epilepsy patients who do not respond to conventional anti-seizure medications.

All three participants experienced a reduction of more than 90% in their monthly seizure frequency after the treatment. No serious side effects were reported during the study.

The results were reported today in The New England Journal of Medicine by Yang Dai, a neurosurgeon at Xuanwu Hospital of Capital Medical University in Beijing, and his colleagues.

“It’s exciting that there’s such a dramatic effect, and that they see very few side effects,” says Matthew Walker, a neurologist at University College London who was not associated with the study.

How Does the Experimental Gene Therapy Work?

Also read: TV Actor Anuj Thakur Dies At 33 After Suffering A Seizure In His Sleep: When Can Nocturnal Seizures Turn Fatal

The treatment uses a modified virus called adeno-associated virus 9 (AAV9) to deliver genetic instructions directly into the part of the brain from where seizures stem.

The virus carries a gene that instructs specific neurons, known as excitatory neurons, to produce a receptor that are sensitive to a particular medication.

Once the gene is delivered, patients take clozapine, which is an antipsychotic medication. The drug activates the receptors, reducing the activity of the neurons and helping suppress the electrical signals that cause seizures.

Researchers describe the medication as a kind of dimmer switch because it allows them to adjust the activity of the genetically modified brain cells.

Unlike conventional gene therapies, this approach gives researchers a way to regulate the treatment using medication.

What Did The Clinical Trial Find?

Also read: Woman With Epilepsy Dies After Following ChatGPT’s Advice To Stop Medication: Why AI Cannot Replace A Doctor

The study was led by neurosurgeon Yang Dai of Xuanwu Hospital, Capital Medical University, in Beijing.

It involved three adults with drug-resistant epilepsy caused by hippocampal sclerosis, a condition in which scarring develops in the hippocampus, a brain region involved in memory and seizure activity.

All three participants had experienced epilepsy for 10 to 25 years. Despite trying at least two anti-seizure medications, their seizures still remained out of control.

They also experienced at least two seizures per month on average during the three months before entering the trial.

After gene therapy all three participants saw a reduction of more than 90% in their monthly seizure frequency.

Significant Discovery For People With Drug-Resistant Epilepsy

Also read: Can ChatGPT Replace Your Doctor? Why Epilepsy Patients Should Never Alter Medication on AI Advice

Epilepsy is a neurological disorder characterised by recurrent seizures caused by abnormal electrical activity in the brain.

Anti-seizure medications can help many people control their seizures. However, some patients continue to experience seizures despite trying multiple medications.

This is known as drug-resistant epilepsy. According to the International League Against Epilepsy, it generally refers to a failure to achieve control of seizure after sufficient trials of two anti-seizure medications.

Surgery may be an option for patients with focal epilepsy if doctors can identify the brain region responsible for seizures.

Limitations Of The Study

The new gene therapy takes a different approach by targeting the neurons responsible for seizures.

However, experts have raised concerns about the long-term use of clozapine. High doses of the drug have been associated with cardiovascular complications and other adverse effects.

Despite the reduction in seizures, researchers have warned against interpreting the findings as proof that the treatment is effective for all people with epilepsy.

The trial involved only three participants, making it too small to probe the treatment’s long-term safety or effectiveness.

All three also had a specific form of epilepsy related to hippocampal scarring on one side of the brain. The findings cannot automatically be applied to people with other forms of epilepsy or seizures originating in different brain regions.