“I'm not great at the advice. Can I interest you in a sarcastic comment?”

This is what ‘Friends’ actor Matthew Perry’s character Chandler Bing was known for. He was known for being funny. However, he had his own struggles in his personal life and those struggles were acute depression. He was treating it with ketamine infusion therapy which is legal in the US and the UK.

What is Ketamine infusion therapy?

Ketamine is an anaesthetic used to treat depression, anxiety and pain under supervised and controlled medical settings. However, it does have its side effects, which can lead to distortion of sight, sound and time. It can also produce calming and relaxing effects.

Ketamine increases a person’s heart rate and blood pressure. If overdosed, it can leave users confused and agitated and can cause them to hurt themselves without even realising it. It can also lead to liver damage and bladder problems.

However, when used in moderation and under the supervision of medical doctors, it can treat depression where traditional antidepressants have failed.

Prof Rupert McShane, a University of Oxford psychiatrist who runs an NHS ketamine treatment clinic told BBC that ketamine “probably turns off the area of the brain that is involved in disappointment.”

Can Ketamine Infusion Therapy Kill Someone?

In simple terms, it cannot, be if the dosage is given in a controlled setting and as prescribed. Ketamine infusion therapy uses drugs in small doses than those used for anaesthesia. It acts faster than traditional anti-depressants, but the effects also wear off way quickly. Which is why it is important to monitor patients’ mental state for relapsing back into depression and discouraging them from overdosing on it.

There are ways of giving people ketamine. One of the ways is through “infusing”, which means to use an IV drip. However, injections, nasal sprays and capsules are also methods used to give people ketamine.

Since the dosage of ketamine used in the infusion treatment is small, it being the reason of actor Perry’s death was ruled out. The medical examiner also noted that Perry’s last ketamine infusion therapy session happened more than a week before his death, which means by the time he had died, it must have worn off.

So, What Happened To Perry?

Though Perry’s last session was more than a week before, his post-mortem showed that his blood contained a high concentration of ketamine. He had died of the “acute effects” of ketamine.

If it was not his session, then how did he get ketamine?

Prosecutors alleged that his assistant gave him at least 27 shots of ketamine in four days before his death, reported BBC.

Perry has been open about his personal struggles and this is what the doctors and dealers used against him. Martin Estrada, the US attorney for California’s Central District told the BBC that people took advantage of his condition. They charged him 165 times more than what vials of ketamine cost.

Names that have come up include Dr Salvador Plasencia, drug dealers “Ketamine Queen” aka Jasveen Sangha and Eric Fleming, and Perry’s live-in assistant Kenneth Iwamasa.

Who Are These Names And What Did They Do?

Ketamine Queen or Sangha supplied drugs that led to Perry’s death. Her home was a “drug-selling emporium,” said Estrada. More than 80 vials of ketamine, and thousands of pills including methamphetamine, cocaine and Xanax were allegedly found in her house known as the “Sangha Stash House.”

Sangha is known to deal with high-end celebs and was a “major source of supply for ketamine to others as well as Perry,” said Estrada.

Dr Plasencia called Perry a “moron” while charging him $2,000 for vials that cost only $12. He sold Perry 20 vials of ketamine between September and October 2023, costing $55,000.

He was the one who taught Iwamasa, who had no medical knowledge to inject the drug. This is after he knew that “Perry’s ketamine addiction was spiralling out of control,” as per what the investigators told the BBC.

Another dealer Fleming was told by Sangha to “delete all our messages.” While Fleming pleaded guilty to conspiring to distribute drugs unlawfully, he also allegedly messaged Sangha: “Please call...Got more info and want to bounce ideas off you. I’m 90% sure everyone is protected. I never dealt with [Perry] only his assistant. So the assistant was the enabler.”

The court documents also revealed that he asked Sangha on whether the ketamine stays in your system or “is it immediately flushed out.”

Dr Pepper, Bots, Cans

The people who allegedly exploited Perry used coded language for ketamine and called it “Dr Pepper”, “bots”, or “cans.”

Selling overpriced drugs, taking advantage of Perry’s mental condition and falsifying medical records to make the drugs given to him look legitimate by Dr Plasencia is what took Perry’s life.

Iwamasa is said to have administered more than 20 shots of ketamine and three on the day Perry died. Whereas ketamine is only administered by a physician. Authorities also found that weeks before Perry’s death, Dr Plasencia allegedly bought 10 vials of ketamine and intended to sell to Perry.

He also injected Perry with a large dose, two days later. This caused him to “freeze up” and spiked his blood pressure.

When I Die, I Want Helping Others To Be The First Thing That’s Mentioned

Perry had always been open about his drug addictions, struggles with alcohol and his depression. He said that his openness would help others who are also struggling and wanted to be remembered by his quote which also is on the homepage of the Mattew Perry Foundation that helps others struggling with the disease of addiction: “When I die, I want helping others to be the first thing that’s mentioned.”

Five arrests have been made in the case so far.

Health authorities in Kerala have sounded an alarm following five suspected cases of West Nile fever (WNF) in Ernakulam.

The cases were reported from Elanji, Eroor in Thripunithura, Pallikkara in Kizhakkambalam, Ponekkara in Edappally, and Palluruthy, The Hindu reported.

While the cases are yet to be ascertained, the southern state of India has a prevalence of mosquito-borne diseases during the summer months.

“We haven’t received any confirmation of WNF cases. These are suspected cases and can be confirmed only after tests are carried out," Dr. R. Shahirsha, District Medical Officer (DMO), Ernakulam, was quoted as saying.

Notably, the authorities have sent the samples for testing, and results will be available in 14 days.

"While no cluster has been observed, precautionary measures to prevent mosquito breeding need to be implemented,” Dr Shahirsha said. Keeping canals clean and preventing mosquito breeding inside homes and in surrounding areas are critical steps, the authorities said.

What is West Nile Fever

The disease is spread through mosquito bites, and most who get infected do not have any symptoms. However, one in every five infected people has a fever, headache, body aches, and other flu-like symptoms.

The West Nile virus also infects the nervous system and is capable of causing serious brain or spinal cord inflammation.

According to the WHO, West Nile Virus is a member of the flavivirus genus and belongs to the Japanese encephalitis antigenic complex of the family Flaviviridae.

The mosquitoes become infected when they feed on birds that carry the virus in their blood, and then bite humans and infect them.

It is found in different parts of the world, including North America, Europe, Africa, Central Asia, Australia, and Asia. Cases in 49 states in the US have been reported, and the total number of symptomatic cases in the US is 51,000 since the first cases were detected in the country in 1999.

What Are The Symptoms?

The symptoms include fever, headache, muscle aches, nausea and vomiting, diarrhoea, rash around the chest and back, swollen lymph nodes, sore throats, and pain behind the eyes.

In severe cases, individuals may have an intense headache, high fever, stiff neck, making you unable to move your chin towards your chest, confusion, muscle weakness, loss of control over your muscle movements, seizures, paralysis, and coma.

How Can It Spread?

While the mosquitoes that feed on infected birds are the carriers, there is still a lack of evidence to determine whether it comes directly from the birds. The incubation period for symptoms to show up is two to six days, but it can extend to 14 days, too.

It can be transmitted from a pregnant person to their fetus, through human milk, blood transfusion, and organ transplant. People who are over the age of 60, have cancer, diabetes, or high blood pressure are more prone to the virus.

Why Is It called West Nile Fever?

It gets its name from the West Nile district, where it was first discovered in 1937 in Uganda.

Treatment

There are no treatments or antiviral medications available for it. However, you can treat the mild symptoms at home with over-the-counter medications that you take for a cold or the flu. The best way to prevent is to protect yourself from mosquito bites.

In a landmark deal, India and New Zealand today signed the India- New Zealand Free Trade Agreement (IN- NZ FTA).

The Agreement was signed by Union Minister of Commerce and Industry Piyush Goyal and New Zealand’s Minister for Trade and Investment Todd McClay at Bharat Mandapam, New Delhi.

The FTA will not only strengthen India’s global economic partnerships but also boost strategic opportunities for the medical devices sector, as well as the country's traditional medicine sector.

In a post on social media platform X, Prime Minister Narendra Modi highlighted the agreement’s "role in promoting traditional knowledge systems, including AYUSH, yoga and organic products, positioning them for greater global relevance".

"The FTA broadens its scope to agriculture productivity, organics, services, mobility, Ayush, and pharma access, making the opportunities all-inclusive and future-oriented," added Commerce Secretary Rajesh Agrawal.

What The FTA Brings To India

For the first time, New Zealand has facilitated trade in Ayurveda, yoga, and other traditional medicine services with India. This landmark provision promotes the global recognition of India’s AYUSH systems, supports medical value travel, and encourages collaboration in wellness services, according to an official statement.

It also reinforces India’s position as a global hub for health, wellness, and traditional medicine services. It gives centre stage to India’s AYUSH disciplines (Ayurveda, Yoga & Naturopathy, Unani, Sowa-Rigpa, Siddha, and Homeopathy) alongside Maori Health practices.

In a major breakthrough, the FTA streamlines access for pharmaceuticals and medical devices by enabling acceptance of GMP and GCP inspection reports from comparable regulators, including approvals by the US FDA, EMA, UK MHRA, Health Canada, and other comparable regulators.

"These will reduce duplicative inspections, lower compliance costs, and expedite product approvals, thereby facilitating smoother market access and supporting growth of India’s pharmaceutical and medical devices exports to New Zealand," it added.

What Are The Industry Leaders Saying?

The experts hailed the India–New Zealand FTA, calling it a strategic opportunity for the medical devices sector.

"For the healthcare and MedTech sector, the agreement is particularly consequential. A dedicated annex on pharmaceuticals and medical devices creates expedited regulatory pathways, with New Zealand agreeing to recognize GMP and GCP inspection reports from the US FDA, the EU’s EMA, and the UK’s MHRA—reducing duplicative compliance burdens and accelerating product approvals for Indian manufacturers," said Pavan Choudary, Chairman, Medical Technology Association of India (MTaI), in a statement.

"A separate annex on health services and traditional medicine opens structured avenues for medical value travel, digital health, and evidence-based AYUSH, positioning India not merely as a goods exporter, but as a global wellness and healthcare services hub," he added.

Rajiv Nath, Forum Coordinator, Association of Indian Medical Devices Industry (AiMeD), also welcomed the India-New Zealand FTA and said that the reduced tariffs and streamlined regulatory cooperation will boost exports.

It will also "enable technology partnerships, and support affordable access to quality devices. The pact enhances competitiveness for Indian manufacturers while ensuring resilient supply chains and mutual recognition standards, strengthening India’s position as a global MedTech hub," Nath added.

However, Choudary cited that there is a significant gap. He cited that the FTA’s regulatory recognition framework does not yet include India’s Central Drugs Standard Control Organization (CDSCO).

"As India’s pharmaceutical and MedTech industry grows in scale, quality, and global reach, the CDSCO is rapidly maturing into a credible, reference-class regulator. Its inclusion in such bilateral recognition frameworks is not a diplomatic nicety; it is a commercial and strategic imperative. Future trade agreements, and indeed revisions to this one, must correct this omission," the expert said.

A new analysis by researchers at the Indian Council of Medical Research (ICMR) points to a mixed picture when it comes to cancer trends in India. While cases of breast cancer and oral cancer in men have been steadily rising over the years, cervical cancer has seen a sharp decline—one of the few clear positives in the data.

Cancer pattern in India

The study, published in the Journal of Public Health, looked at patterns across G20 countries over roughly two decades. Researchers used a method that helps separate the effects of ageing from broader social and behavioural changes. In simple terms, it allowed them to see whether cancer risk itself is increasing, or if higher numbers are just a result of people living longer.

For India, the rise in certain cancers is difficult to ignore. Breast cancer cases have been increasing by around 1.8 per cent each year, while oral cancer in men has gone up by about 1.2 per cent annually. These trends stand in contrast to several high-income countries, where rates have either slowed or, in some cases, begun to fall.

Why are breast cancer cases on the rise?

The reason why breast cancer cases are surging in India is not surprising - with the shift in lifestyle choices, it is almost a no-brainer. Rising obesity, sedentary lifestyle, smoking and alcohol use are some of the key contributors. Reproductive patterns, too, have changed - women are planning pregnancies later, breastfeeding for short duration and also experiencing early onset of periods. While these factors may appear insignificant individually, they collectively play a huge role in the long run.

Oral cancer in India

Oral cancer tells a different story—one that is closely tied to India’s long-standing tobacco habits. The use of smokeless tobacco and betel quid continues to be widespread, particularly among men. Alcohol adds to the risk. What makes the situation worse is that many cases are picked up late, often when the disease is already advanced. The data also shows a clear age pattern: men and women have similar rates until about 40, after which the numbers for men rise sharply.

If there is one area where India has made real progress, it is cervical cancer. The study found that incidence has been dropping by over 4 per cent each year, one of the steepest declines among the countries analysed. Experts attribute this to better awareness, improved hygiene, and gradual improvements in reproductive health services over time.

This decline offers a useful lesson. It shows that sustained public health efforts can make a difference. The recent rollout of HPV vaccination for adolescent girls could push these numbers down even further in the coming years.

Cancer diagnosis and treatment pattern in India

The ICMR report also highlights a big concern - in developed countries, cancer risk decreases with the new generation because of improved diagnosis and treatment infrastructure. However, in India, the pattern is not evident enough - risk appears high across age groups, but the diagnosis and treatment bit is not well taken care of. Lack of mortality data in India is a key concern, which makes it hard to assess how the rising numbers translate to heightened death risk. The trend is still strong enough to require immediate intervention.

Can India's rising cancer burden be curbed?

Researchers say the response cannot be one-dimensional. Expanding access to screening, especially for breast cancer, is crucial. Tobacco and alcohol control policies need to be enforced more effectively to tackle oral cancer. At the same time, the gains seen in cervical cancer underline the importance of vaccination and organised screening programmes.