“I'm not great at the advice. Can I interest you in a sarcastic comment?”

This is what ‘Friends’ actor Matthew Perry’s character Chandler Bing was known for. He was known for being funny. However, he had his own struggles in his personal life and those struggles were acute depression. He was treating it with ketamine infusion therapy which is legal in the US and the UK.

What is Ketamine infusion therapy?

Ketamine is an anaesthetic used to treat depression, anxiety and pain under supervised and controlled medical settings. However, it does have its side effects, which can lead to distortion of sight, sound and time. It can also produce calming and relaxing effects.

Ketamine increases a person’s heart rate and blood pressure. If overdosed, it can leave users confused and agitated and can cause them to hurt themselves without even realising it. It can also lead to liver damage and bladder problems.

However, when used in moderation and under the supervision of medical doctors, it can treat depression where traditional antidepressants have failed.

Prof Rupert McShane, a University of Oxford psychiatrist who runs an NHS ketamine treatment clinic told BBC that ketamine “probably turns off the area of the brain that is involved in disappointment.”

Can Ketamine Infusion Therapy Kill Someone?

In simple terms, it cannot, be if the dosage is given in a controlled setting and as prescribed. Ketamine infusion therapy uses drugs in small doses than those used for anaesthesia. It acts faster than traditional anti-depressants, but the effects also wear off way quickly. Which is why it is important to monitor patients’ mental state for relapsing back into depression and discouraging them from overdosing on it.

There are ways of giving people ketamine. One of the ways is through “infusing”, which means to use an IV drip. However, injections, nasal sprays and capsules are also methods used to give people ketamine.

Since the dosage of ketamine used in the infusion treatment is small, it being the reason of actor Perry’s death was ruled out. The medical examiner also noted that Perry’s last ketamine infusion therapy session happened more than a week before his death, which means by the time he had died, it must have worn off.

So, What Happened To Perry?

Though Perry’s last session was more than a week before, his post-mortem showed that his blood contained a high concentration of ketamine. He had died of the “acute effects” of ketamine.

If it was not his session, then how did he get ketamine?

Prosecutors alleged that his assistant gave him at least 27 shots of ketamine in four days before his death, reported BBC.

Perry has been open about his personal struggles and this is what the doctors and dealers used against him. Martin Estrada, the US attorney for California’s Central District told the BBC that people took advantage of his condition. They charged him 165 times more than what vials of ketamine cost.

Names that have come up include Dr Salvador Plasencia, drug dealers “Ketamine Queen” aka Jasveen Sangha and Eric Fleming, and Perry’s live-in assistant Kenneth Iwamasa.

Who Are These Names And What Did They Do?

Ketamine Queen or Sangha supplied drugs that led to Perry’s death. Her home was a “drug-selling emporium,” said Estrada. More than 80 vials of ketamine, and thousands of pills including methamphetamine, cocaine and Xanax were allegedly found in her house known as the “Sangha Stash House.”

Sangha is known to deal with high-end celebs and was a “major source of supply for ketamine to others as well as Perry,” said Estrada.

Dr Plasencia called Perry a “moron” while charging him $2,000 for vials that cost only $12. He sold Perry 20 vials of ketamine between September and October 2023, costing $55,000.

He was the one who taught Iwamasa, who had no medical knowledge to inject the drug. This is after he knew that “Perry’s ketamine addiction was spiralling out of control,” as per what the investigators told the BBC.

Another dealer Fleming was told by Sangha to “delete all our messages.” While Fleming pleaded guilty to conspiring to distribute drugs unlawfully, he also allegedly messaged Sangha: “Please call...Got more info and want to bounce ideas off you. I’m 90% sure everyone is protected. I never dealt with [Perry] only his assistant. So the assistant was the enabler.”

The court documents also revealed that he asked Sangha on whether the ketamine stays in your system or “is it immediately flushed out.”

Dr Pepper, Bots, Cans

The people who allegedly exploited Perry used coded language for ketamine and called it “Dr Pepper”, “bots”, or “cans.”

Selling overpriced drugs, taking advantage of Perry’s mental condition and falsifying medical records to make the drugs given to him look legitimate by Dr Plasencia is what took Perry’s life.

Iwamasa is said to have administered more than 20 shots of ketamine and three on the day Perry died. Whereas ketamine is only administered by a physician. Authorities also found that weeks before Perry’s death, Dr Plasencia allegedly bought 10 vials of ketamine and intended to sell to Perry.

He also injected Perry with a large dose, two days later. This caused him to “freeze up” and spiked his blood pressure.

When I Die, I Want Helping Others To Be The First Thing That’s Mentioned

Perry had always been open about his drug addictions, struggles with alcohol and his depression. He said that his openness would help others who are also struggling and wanted to be remembered by his quote which also is on the homepage of the Mattew Perry Foundation that helps others struggling with the disease of addiction: “When I die, I want helping others to be the first thing that’s mentioned.”

Five arrests have been made in the case so far.

Vitruvias Therapeutics’ thyroid medication, recalled nationwide in August, has been elevated to the highest risk level by the US FDA.

The recall was issued because the medication may be superpotent, potentially causing hyperthyroidism (overactive thyroid).

On Wednesday, the FDA updated the recall to Class I, its most serious recall classification. It applies when there is a “reasonable probability that the use of or exposure to a violative product will cause serious adverse health consequences or death.”

Which Thyroid Tablets Have Been Recalled?

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The affected product is:

• Vitruvias Thyroid Tablets USP 30 mg
• Lot number: 504950
• Expiration date: September 30, 2026

In its August 24 recall notice, the company said the tablets were potentially superpotent.

Risks of Superpotent Thyroid Medicines

Millions of people with hypothyroidism rely on thyroid tablets every day to replace hormones their bodies cannot produce.

However, taking superpotent thyroid tablets can cause hyperthyroidism (overactive thyroid). It can force the body's metabolism into overdrive, speeding up organs and bodily functions.

Left untreated, this constant strain can cause serious health complications across multiple systems in the body.

In addition, people taking the medication can be at risk of

• weight loss,
• heat intolerance,
• fatigue,
• nervousness,
• muscle weakness,
• hypertension,
• chest pain,
• rapid heart rate,
• heart rhythm disturbances.

The lot was distributed nationwide in the US to Vitruvias Therapeutics’ direct accounts between January 31 and September 30, 2025. Of 3,655 units released, 1,955 were sold.

Read More: FDA Recalls Popular Thyroid Medication: What Levothyroxine Users Need to Know

Who Is At Greater Risk?

The company identified the following groups as being at greater risk from superpotent thyroid tablets:

• Elderly people
• Pregnant women
• Infants

Excess thyroid hormones in older adults have been associated with adverse outcomes, particularly those affecting the heart.

Vitruvias Therapeutics said it has not received any reports of adverse events known to be linked to the recall.

The company is notifying wholesalers to stop distributing the recalled product and arranging for its destruction.

What Should Patients Do?

Patients taking Thyroid, USP from Lot 504950 should not stop taking it without first contacting their healthcare provider for guidance and/or a replacement prescription.

Hypothyroidism vs Hyperthyroidism

Speaking to HealthandMe, Dr Shruti Kotangale, Consultant Gynaecologist, Obstetrician and Infertility Expert at AIMS Hospital, Dombivli, explained that both conditions are commonly seen in women.

Hypothyroidism occurs when the thyroid is underactive. Symptoms can include tiredness, weight gain, dry skin, hair fall, constipation, feeling cold, a slow heartbeat and low mood or depression.

Hyperthyroidism occurs when the thyroid is overactive. Symptoms may include weight loss, a fast heartbeat, sweating, anxiety, tremors, irritability, frequent bowel movements and difficulty sleeping.

Women should seek medical attention and manage these symptoms without delay.

Common Symptoms Of Thyroid Disorders

Thyroid disorders may cause a range of symptoms, including:

• Fatigue
• Cognitive changes
• Gastrointestinal problems
• Sensitivity to cold
• Skin and hair changes
• Weight changes

How Is Thyroid Disease Diagnosed?

Diagnosis may involve:

• Physical examination: To check for swelling or nodules in the neck.
• Blood tests: These may measure TSH, T4 and T3 levels, along with thyroid antibodies when conditions such as Hashimoto’s disease or Graves’ disease are suspected.
• Ultrasound or thyroid scans may also be used to assess the thyroid’s structure.

American racing champion and NASCAR Hall of Famer Darrell Waltrip has been diagnosed with Frontotemporal Dementia (FTD), his family has announced.

The 79-year-old former NASCAR driver and broadcaster will be stepping further away from public life following the diagnosis.

According to his family, Waltrip has FTD, which is being complicated by possible chronic traumatic encephalopathy (CTE), which they believe may be linked to injuries sustained during his racing career from 1972 to 2000.

“We wanted to share a health update with all of Darrell’s friends and fans who have supported him throughout his racing career. Recently, Darrell has been diagnosed with Frontotemporal Degeneration (FTD) complicated by possible Chronic Traumatic Encephalopathy (CTE) — likely from injuries incurred during his racing career,” the family said in a statement.

The family said Waltrip currently has only “minor noticeable symptoms” and is “happy and otherwise healthy,” spending time with his wife, Stevie, and their two daughters.

Why Can Repeated Head Injuries Raise CTE Concerns?

Chronic traumatic encephalopathy (CTE) is a progressive brain disease believed to be associated with repeated head injuries. It has most commonly been studied in contact-sport athletes and military personnel exposed to repeated head trauma.

Experts are still studying how the number and severity of head injuries contribute to CTE risk. Importantly, not everyone exposed to repeated head injuries develops CTE, and the condition can currently be definitively diagnosed only after death through examination of brain tissue.

A 2026 study led by researchers at Boston University and Harvard Medical School found that roughly one in four former NFL players who died between 2016 and 2021 had CTE.

CTE And Racing

Although CTE has historically received considerable attention in American football and other contact sports, repeated head impacts can occur in motorsports as well.

Waltrip is not alone. NASCAR Hall of Famer Fred Lorenzen was diagnosed with CTE by researchers after he died in 2024.

What Is Frontotemporal Degeneration?

Read More: The First Symptom of Bruce Willis’ Frontotemporal Dementia That Left His Wife Emma Heming Stunned

Frontotemporal degeneration, also known as frontotemporal dementia (FTD), refers to a group of brain disorders that primarily affect the frontal and temporal lobes.

These areas are involved in personality, behavior, language, and other functions. Unlike Alzheimer's disease, memory loss may not be the first or most prominent symptom of FTD.

FTD can develop at a younger age than many other forms of dementia, sometimes affecting people in their 40s or 50s.

The condition can cause changes in:

• Personality and behavior
• Judgment and decision-making
• Emotional responses and empathy
• Speech and language
• Movement and coordination

What Are The Symptoms Of FTD?

Symptoms vary depending on which areas of the brain are most affected and generally worsen over time.

Behavioral Symptoms

• Personality and behavior changes
• Loss of empathy
• Poor judgment and impulsivity
• Socially inappropriate behavior
• Apathy or loss of interest
• Repetitive or compulsive behavior

• Difficulty finding words
• Trouble understanding speech or writing
• Difficulty naming objects
• Increasing difficulty speaking

• Tremors or stiffness
• Muscle weakness or spasms
• Poor balance and falls
• Difficulty swallowing
• Changes in speech or movement

Darrell Waltrip's Racing Legacy

Waltrip is one of NASCAR's most accomplished drivers, with 84 Cup Series victories and three Cup Series championships.

He won the Daytona 500 in 1989 and the Southern 500 in 1992. He also won the Coca-Cola 600 five times, making him the winningest driver in the race's history.

Waltrip later became a familiar voice in NASCAR broadcasting, working as a commentator for many years.

The UK NHS is set to review around 4,500 more breast cancer cases dating back to 2015 after a review found delayed diagnoses and 20 cases involving unnecessary breast removal surgery.

Hundreds of patients suffered harm under County Durham and Darlington NHS Foundation Trust in north-east England., according to the review.

The Trust has apologized and is using specialists from other hospitals to determine whether more women underwent unnecessary operations or received poor care.

"The trust will complete the reviews already under way covering care between January 2023 and February 2025. It will then look back one year at a time, starting with patients treated in 2022 and working backwards towards 2015," it said in a statement.

Review Could Cover 4,500 Cases

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Board chair Alison Marshall apologized to women and families affected by the failings.

"I would like to offer a sincere apology to all the women and their families who have been affected by the failings in our breast services," she said, according to the BBC.

"I can't imagine the impact that has had."

She said the Trust could "not turn back the clock" but would be "open, honest and transparent" about the failings.

Chief nurse Gill Hunt said concerns were first raised in 2015 following a "service reconfiguration" and the loss of breast surgical trainee posts.

Till September 2, 2026, a total of 539 cases had been reviewed, and is expected to examine around 4,500 cases if it extends back to 2015.

The Trust said each year's findings will be "carefully considered" before it moves to the next earlier year. As per the report, the review could take five years, with women treated in 2015 potentially having their cases reviewed as late as 2031.

The admission came after the BBC reported last year that more than 200 patients were found to have suffered harm at the CDDFT.

"We have heard again today about the profound and lasting impact that failings in our breast services have had on women and their families," said Chief executive Steve Russell.

"We remain deeply sorry for the harm and distress caused, and for the times when, as a Trust, we should have listened more carefully, asked more questions and acted sooner," Russell added.

About 640 patients have contacted a special helpline seeking a review of their cases. The current review cost about £523,000 in its first year and involved nine reviewers examining around 80 cases a month.

20 Women Had Unnecessary Mastectomies

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About 514 cases reviewed by the trust so far, between January 2023 and February 2025, alongside the cases of 640 former patients who contacted a dedicated helpline.

Of the 514 cases, 315 patients have been found to have suffered harm, including 77 who were significantly harmed. One patient is known to have died.

The Trust was found to have a high number of mastectomies compared with other NHS trusts, with operations carried out "too quickly".

Breast Cancer Burden In UK

Breast cancer is the most common cancer in the UK, accounting for roughly 15% of all new cancer cases.

Around 60,763 new cases are diagnosed each year, according to Breast Cancer UK. An estimated 14,000-15,000 mastectomies are performed annually in the UK.

What Is A Mastectomy?

A mastectomy is surgery to remove the whole breast. Depending on the cancer, nearby lymph nodes and surrounding tissue may also be removed. It may be performed on one or both breasts depending on the type of cancer and individual risk factors.

Some patients may undergo breast reconstruction after a mastectomy to restore breast shape and symmetry.