“I'm not great at the advice. Can I interest you in a sarcastic comment?”

This is what ‘Friends’ actor Matthew Perry’s character Chandler Bing was known for. He was known for being funny. However, he had his own struggles in his personal life and those struggles were acute depression. He was treating it with ketamine infusion therapy which is legal in the US and the UK.

What is Ketamine infusion therapy?

Ketamine is an anaesthetic used to treat depression, anxiety and pain under supervised and controlled medical settings. However, it does have its side effects, which can lead to distortion of sight, sound and time. It can also produce calming and relaxing effects.

Ketamine increases a person’s heart rate and blood pressure. If overdosed, it can leave users confused and agitated and can cause them to hurt themselves without even realising it. It can also lead to liver damage and bladder problems.

However, when used in moderation and under the supervision of medical doctors, it can treat depression where traditional antidepressants have failed.

Prof Rupert McShane, a University of Oxford psychiatrist who runs an NHS ketamine treatment clinic told BBC that ketamine “probably turns off the area of the brain that is involved in disappointment.”

Can Ketamine Infusion Therapy Kill Someone?

In simple terms, it cannot, be if the dosage is given in a controlled setting and as prescribed. Ketamine infusion therapy uses drugs in small doses than those used for anaesthesia. It acts faster than traditional anti-depressants, but the effects also wear off way quickly. Which is why it is important to monitor patients’ mental state for relapsing back into depression and discouraging them from overdosing on it.

There are ways of giving people ketamine. One of the ways is through “infusing”, which means to use an IV drip. However, injections, nasal sprays and capsules are also methods used to give people ketamine.

Since the dosage of ketamine used in the infusion treatment is small, it being the reason of actor Perry’s death was ruled out. The medical examiner also noted that Perry’s last ketamine infusion therapy session happened more than a week before his death, which means by the time he had died, it must have worn off.

So, What Happened To Perry?

Though Perry’s last session was more than a week before, his post-mortem showed that his blood contained a high concentration of ketamine. He had died of the “acute effects” of ketamine.

If it was not his session, then how did he get ketamine?

Prosecutors alleged that his assistant gave him at least 27 shots of ketamine in four days before his death, reported BBC.

Perry has been open about his personal struggles and this is what the doctors and dealers used against him. Martin Estrada, the US attorney for California’s Central District told the BBC that people took advantage of his condition. They charged him 165 times more than what vials of ketamine cost.

Names that have come up include Dr Salvador Plasencia, drug dealers “Ketamine Queen” aka Jasveen Sangha and Eric Fleming, and Perry’s live-in assistant Kenneth Iwamasa.

Who Are These Names And What Did They Do?

Ketamine Queen or Sangha supplied drugs that led to Perry’s death. Her home was a “drug-selling emporium,” said Estrada. More than 80 vials of ketamine, and thousands of pills including methamphetamine, cocaine and Xanax were allegedly found in her house known as the “Sangha Stash House.”

Sangha is known to deal with high-end celebs and was a “major source of supply for ketamine to others as well as Perry,” said Estrada.

Dr Plasencia called Perry a “moron” while charging him $2,000 for vials that cost only $12. He sold Perry 20 vials of ketamine between September and October 2023, costing $55,000.

He was the one who taught Iwamasa, who had no medical knowledge to inject the drug. This is after he knew that “Perry’s ketamine addiction was spiralling out of control,” as per what the investigators told the BBC.

Another dealer Fleming was told by Sangha to “delete all our messages.” While Fleming pleaded guilty to conspiring to distribute drugs unlawfully, he also allegedly messaged Sangha: “Please call...Got more info and want to bounce ideas off you. I’m 90% sure everyone is protected. I never dealt with [Perry] only his assistant. So the assistant was the enabler.”

The court documents also revealed that he asked Sangha on whether the ketamine stays in your system or “is it immediately flushed out.”

Dr Pepper, Bots, Cans

The people who allegedly exploited Perry used coded language for ketamine and called it “Dr Pepper”, “bots”, or “cans.”

Selling overpriced drugs, taking advantage of Perry’s mental condition and falsifying medical records to make the drugs given to him look legitimate by Dr Plasencia is what took Perry’s life.

Iwamasa is said to have administered more than 20 shots of ketamine and three on the day Perry died. Whereas ketamine is only administered by a physician. Authorities also found that weeks before Perry’s death, Dr Plasencia allegedly bought 10 vials of ketamine and intended to sell to Perry.

He also injected Perry with a large dose, two days later. This caused him to “freeze up” and spiked his blood pressure.

When I Die, I Want Helping Others To Be The First Thing That’s Mentioned

Perry had always been open about his drug addictions, struggles with alcohol and his depression. He said that his openness would help others who are also struggling and wanted to be remembered by his quote which also is on the homepage of the Mattew Perry Foundation that helps others struggling with the disease of addiction: “When I die, I want helping others to be the first thing that’s mentioned.”

Five arrests have been made in the case so far.

The Union Ministry of Health and Family Welfare has proposed mandatory CCTV surveillance at medical stores as an additional regulatory safeguard for prescription drugs.

The move, proposed under amendments to the Drugs Rules, 1945, through Draft Gazette Notification G.S.R. 791 (E), aims to strengthen regulatory oversight of Schedule H, H1 and X drugs.

Once implemented, it will help strengthen monitoring of the sale and distribution of these drugs and curb their unauthorized access and sale without valid prescriptions.

The proposed CCTV surveillance mechanism will also enhance transparency and accountability across the pharmaceutical supply chain, strengthening safeguards for public health. The draft proposal is now open to public objections and suggestions before it is finalized.

What Are Schedule H, H1 And X Drugs?

Schedule H: Prescription-only medicines, including many blood pressure, diabetes and anti-infective drugs. They must carry the Rx symbol and cannot be sold without a prescription.

Schedule H1: A stricter category covering certain antibiotics, anti-tuberculosis drugs and sedatives. These medicines carry a red-boxed Rx warning and require medical advice.

Schedule X: The strictest category, covering certain high-risk narcotic and psychotropic drugs such as morphine, amphetamines and strong barbiturates. Their sale requires a specific government licence in addition to a standard retail drug licence.

Why Is CCTV Surveillance Being Proposed At Pharmacies?

India is seeing concerns over spurious and fake drugs, with chemists being the major point of contact for medicines for a majority of people.

A recent nationwide survey by LocalCircles, a community social media platform, showed that 64% of consumers said chemists never or rarely ask for a doctor's prescription, while only 31% mostly got a qualified pharmacist at their chemist.

Only 15% of those surveyed said the chemist mostly or always refused to sell medicines without a prescription.

The survey also found:

• 13% said someone at the chemist assisted them who was not a qualified pharmacist.
• 15% said medicines were found to be fake or counterfeit.
• Another 15% said they received completely ineffective medicines.
• 26% said they were not provided a GST bill.

Counterfeit Medicines Seized In Bengaluru

In a recent shocking case, investigators in Bengaluru seized large counterfeit cancer medicines, life-saving drugs and injections used in intensive care units (ICUs) that were being supplied to hospitals, clinics and medical stores.

According to investigators, the medicines may have been supplied to more than 90 hospitals and clinics in Bengaluru.

A public interest litigation (PIL) has also been filed in the Supreme Court seeking a comprehensive national framework to check the manufacture and sale of counterfeit and adulterated medicines, including vaccines and cough syrups.

Drug Testing Data Shows Continued Quality Concerns

Data placed before Parliament shows that 1,41,322 drug samples were tested in 2025-26, the highest in five years. Of these, 3,012 were found to be Not of Standard Quality (NSQ) and 283 were found to be spurious or adulterated. A total of 779 prosecution cases were filed during the year, while 3,599 cases were filed over five years.

The Central Drugs Standard Control Organisation (CDSCO) has also continued issuing monthly drug alerts through 2026, flagging 240 NSQ samples in January, 194 in February along with four spurious drugs, 168 in March, 157 in May and 159 in June.

Pennsylvania’s measles outbreak has crossed 700 cases, with the state reporting 731 cases, four measles-associated deaths and 141 hospitalizations as of September 16. The four deaths are the first in 35 years in the State and speaks volumes about the severity of the outbreak.

The state has also reported measles cases among vaccinated people, although these account for less than 1% of total cases.

Pennsylvania Seeks CDC Emergency Support

The Pennsylvania Department of Health has requested emergency assistance from the US Centers for Disease Control and Prevention (CDC), known as an Epi-Aid, according to a letter reviewed by Reuters.

However, the request is tied to a dispute over the CDC’s decision not to publicly recognize the four measles-associated deaths.

“The CDC’s choice not to publicly recognize ⁠the deaths undermines our response,” Pennsylvania Health Secretary Debra Bogen wrote to CDC Director Erica Schwartz.

She said the state would rescind its Epi-Aid request if the CDC could not “transparently and accurately communicate information” about the deaths.

Shapiro, Kennedy Clash Over Response

The dispute has also triggered a political clash between Pennsylvania Gov. Josh Shapiro and US Health Secretary Robert F. Kennedy Jr.

Shapiro accused Kennedy of fueling vaccine skepticism, while Kennedy said Shapiro had declined federal assistance. Kennedy has also said the CDC’s MMR recommendation remains unchanged.

“CDC’s MMR recommendation remains unchanged. I have repeatedly stated that MMR vaccination is the most effective way to prevent measles infection,” he said.

Shapiro said Pennsylvania would accept federal assistance but called on Kennedy and the CDC to recognize the four deaths.

Why CDC Is Not Counting The Deaths

The CDC is now using data from the National Center for Health Statistics (NCHS) to track measles deaths, according to a September 4 agency note.

Previously, it used the National Notifiable Diseases Surveillance System (NNDSS) to report such data.

“CDC will report measles deaths if and when the National Center for Health Statistics reports measles as the underlying cause of death,” said Emily Hilliard, a US Department of Health and Human Services spokesperson.

The CDC’s 2026 tally currently shows no measles deaths because NCHS does not yet have records listing measles as the underlying cause.

Measles Can Cause Serious Complications

Measles can cause complications including pneumonia and brain swelling. Nearly 20% of people who contract measles are hospitalized, while death, though rare, occurs in one to three patients per 1,000 cases.

The virus spreads through respiratory droplets and can remain infectious in the air and on surfaces for up to two hours.

Symptoms include fever, cough, runny nose and red, watery eyes, followed by a rash that typically begins on the head and spreads downward. Symptoms can appear 7 to 21 days after exposure.

MMR Vaccine Remains The Best Protection

The best protection against measles is vaccination. Two doses of the MMR vaccine provide 97% protection against measles, according to the Pennsylvania Department of Health.

People with two documented doses generally do not need another. Those with only one dose or without vaccination records should speak with a healthcare provider or pharmacist.

UK’s National Institute for Health and Care Excellence (NICE) has advised healthcare professionals to look for signs of obsessive-compulsive disorder (OCD) and body dysmorphic disorder (BDD) in people seeking cosmetic procedures such as Botox and fillers.

The recommendation is part of a draft guideline aimed at earlier identification of the two conditions, which can remain undiagnosed for years because people may hide symptoms due to shame or embarrassment. In addition, the cosmetic industry is vastly unregulated, increasing potential health risk.

“People with obsessive-compulsive disorder (OCD) and body dysmorphic disorder (BDD) could be identified earlier and offered more appropriate treatment,” said the draft NICE guidance published today.

What Does The NICE Guidance Say?

Also read: Ferritin Face: Can Pale Skin Signal Iron Deficiency?

NICE’s new draft recommends considering assessment for OCD or BDD among people with depression, anxiety, autism or ADHD, as well as those seeking cosmetic procedures.

The committee said symptoms can be overlooked or attributed to other conditions, delaying diagnosis and treatment.

"People with obsessive-compulsive disorder and body dysmorphic disorder can experience symptoms for a long time before they receive the right diagnosis and support. These conditions are often misunderstood, and many people find them difficult to talk about because of embarrassment, shame or fear of being judged,” Eric Power, interim director of the Centre for Guidelines at NICE, said.

Mental Health Checks Before Botox And Fillers

Healthcare professionals providing cosmetic treatments, including surgeons, dentists and dermatologists, would be advised to ask structured questions about appearance-related concerns and document their findings.

If responses suggest possible BDD, NICE recommends specialist assessment rather than proceeding with the cosmetic procedure at that stage.

Read More: More Women Buying Testosterone Without Prescription: Can It Help With Menopause?

The committee noted that cosmetic procedures rarely improve the underlying condition and may sometimes worsen symptoms.

A 2024 systematic review and meta-analysis estimated that 18.6% of people attending aesthetic and reconstructive plastic surgery services had clinically significant BDD symptoms, compared with around 2% of adults in the wider population.

"Our draft recommendations aim to help healthcare professionals recognize symptoms earlier, ask the right questions and support people to access appropriate treatment sooner," Power said.

"Earlier identification can help ensure people receive care that reflects their needs, preferences and circumstances, rather than waiting until symptoms become more severe or reach crisis point," he added.

New Approach To OCD Treatment

The draft guideline also proposes a personalized “matched care” approach to OCD treatment, with interventions based on a person’s clinical needs, treatment history and preferences rather than a fixed sequence.

For children and young people with OCD, the draft recommends family-based cognitive behavioral therapy for many patients.

What Are OCD And BDD?

OCD affects an estimated 1.2% of the population. It involves unwanted, distressing thoughts, images, urges or doubts, often followed by repetitive behaviors or mental rituals such as checking, washing, counting or seeking reassurance.

BDD involves excessive preoccupation with perceived flaws in appearance, which can cause significant distress and interfere with daily life. Research suggests it affects around 2% of adults.

The consultation on the draft NICE guideline is open until October 21, 2026.