“I'm not great at the advice. Can I interest you in a sarcastic comment?”

This is what ‘Friends’ actor Matthew Perry’s character Chandler Bing was known for. He was known for being funny. However, he had his own struggles in his personal life and those struggles were acute depression. He was treating it with ketamine infusion therapy which is legal in the US and the UK.

What is Ketamine infusion therapy?

Ketamine is an anaesthetic used to treat depression, anxiety and pain under supervised and controlled medical settings. However, it does have its side effects, which can lead to distortion of sight, sound and time. It can also produce calming and relaxing effects.

Ketamine increases a person’s heart rate and blood pressure. If overdosed, it can leave users confused and agitated and can cause them to hurt themselves without even realising it. It can also lead to liver damage and bladder problems.

However, when used in moderation and under the supervision of medical doctors, it can treat depression where traditional antidepressants have failed.

Prof Rupert McShane, a University of Oxford psychiatrist who runs an NHS ketamine treatment clinic told BBC that ketamine “probably turns off the area of the brain that is involved in disappointment.”

Can Ketamine Infusion Therapy Kill Someone?

In simple terms, it cannot, be if the dosage is given in a controlled setting and as prescribed. Ketamine infusion therapy uses drugs in small doses than those used for anaesthesia. It acts faster than traditional anti-depressants, but the effects also wear off way quickly. Which is why it is important to monitor patients’ mental state for relapsing back into depression and discouraging them from overdosing on it.

There are ways of giving people ketamine. One of the ways is through “infusing”, which means to use an IV drip. However, injections, nasal sprays and capsules are also methods used to give people ketamine.

Since the dosage of ketamine used in the infusion treatment is small, it being the reason of actor Perry’s death was ruled out. The medical examiner also noted that Perry’s last ketamine infusion therapy session happened more than a week before his death, which means by the time he had died, it must have worn off.

So, What Happened To Perry?

Though Perry’s last session was more than a week before, his post-mortem showed that his blood contained a high concentration of ketamine. He had died of the “acute effects” of ketamine.

If it was not his session, then how did he get ketamine?

Prosecutors alleged that his assistant gave him at least 27 shots of ketamine in four days before his death, reported BBC.

Perry has been open about his personal struggles and this is what the doctors and dealers used against him. Martin Estrada, the US attorney for California’s Central District told the BBC that people took advantage of his condition. They charged him 165 times more than what vials of ketamine cost.

Names that have come up include Dr Salvador Plasencia, drug dealers “Ketamine Queen” aka Jasveen Sangha and Eric Fleming, and Perry’s live-in assistant Kenneth Iwamasa.

Who Are These Names And What Did They Do?

Ketamine Queen or Sangha supplied drugs that led to Perry’s death. Her home was a “drug-selling emporium,” said Estrada. More than 80 vials of ketamine, and thousands of pills including methamphetamine, cocaine and Xanax were allegedly found in her house known as the “Sangha Stash House.”

Sangha is known to deal with high-end celebs and was a “major source of supply for ketamine to others as well as Perry,” said Estrada.

Dr Plasencia called Perry a “moron” while charging him $2,000 for vials that cost only $12. He sold Perry 20 vials of ketamine between September and October 2023, costing $55,000.

He was the one who taught Iwamasa, who had no medical knowledge to inject the drug. This is after he knew that “Perry’s ketamine addiction was spiralling out of control,” as per what the investigators told the BBC.

Another dealer Fleming was told by Sangha to “delete all our messages.” While Fleming pleaded guilty to conspiring to distribute drugs unlawfully, he also allegedly messaged Sangha: “Please call...Got more info and want to bounce ideas off you. I’m 90% sure everyone is protected. I never dealt with [Perry] only his assistant. So the assistant was the enabler.”

The court documents also revealed that he asked Sangha on whether the ketamine stays in your system or “is it immediately flushed out.”

Dr Pepper, Bots, Cans

The people who allegedly exploited Perry used coded language for ketamine and called it “Dr Pepper”, “bots”, or “cans.”

Selling overpriced drugs, taking advantage of Perry’s mental condition and falsifying medical records to make the drugs given to him look legitimate by Dr Plasencia is what took Perry’s life.

Iwamasa is said to have administered more than 20 shots of ketamine and three on the day Perry died. Whereas ketamine is only administered by a physician. Authorities also found that weeks before Perry’s death, Dr Plasencia allegedly bought 10 vials of ketamine and intended to sell to Perry.

He also injected Perry with a large dose, two days later. This caused him to “freeze up” and spiked his blood pressure.

When I Die, I Want Helping Others To Be The First Thing That’s Mentioned

Perry had always been open about his drug addictions, struggles with alcohol and his depression. He said that his openness would help others who are also struggling and wanted to be remembered by his quote which also is on the homepage of the Mattew Perry Foundation that helps others struggling with the disease of addiction: “When I die, I want helping others to be the first thing that’s mentioned.”

Five arrests have been made in the case so far.

A 51-year-old Brazilian businesswoman has died after undergoing six facial cosmetic procedures during surgery lasting several hours.

Andreia Vieira Gaspar, from Goiânia, Brazil, died on August 12, the Daily Star reported.

According to Brazilian news outlet G1 Goiás, the procedures reportedly included a deep facelift, neck liposuction, eyelid surgery, jawline work and other facial procedures.

What Happened?

Andreia reportedly left the operating theatre heavily swollen and struggling to breathe. Her condition worsened overnight, with neck pain and increasing breathing difficulties. She reportedly told her sister, Djiane Vieira: “Sis, I'm dying.”

Djiane then sought help from the medical team through a group chat, saying her sister was dying and asking for immediate assistance.

The Public Ministry of Goiás has requested a police investigation into possible involuntary manslaughter.

The family alleged that Andreia's condition worsened after surgery and questioned whether the hospital was equipped to handle a serious postoperative emergency. They also alleged that it did not have an intensive care unit or an ambulance available.

G1 reported that her condition deteriorated about six hours after surgery and that she died despite resuscitation attempts.

A medical report cited by the family identified acute thrombosis and pulmonary infarction as the causes of death.

Andreia had previously run a beauty salon in Goiânia and had lived in Spain for five years. Her family said undergoing the procedures had been a long-held dream. Her sister said Andreia had spent two years saving for the surgery, which cost BRL 118,000 (£16,800).

How Can Beauty Treatments Go Wrong?

Social media trends, celebrity endorsements and demand for anti-ageing treatments have fueled interest in cosmetic procedures and injectable treatments. Experts warn that unregulated procedures can carry risks, including allergic reactions and infections, while severe complications can affect organs such as the liver and kidneys.

The cosmetic surgery market was estimated at USD 94.1 billion in 2025.

Experts stress that cosmetic procedures should involve realistic expectations, qualified medical advice and a clear understanding of the risks, recovery and costs.

Seven Questions To Ask Before A Cosmetic Procedure

Dr Chintan Gujarati, Cosmetic and Plastic Surgeon at Ruby Hall Clinic, told HealthandMe that cosmetic procedures require careful planning and informed decision-making.

He recommends asking:

1. Is the procedure right for me?

Discuss whether it suits your health, goals and individual needs.

2. Is my surgeon qualified?

Ensure the procedure is performed by a board-certified plastic surgeon or appropriately trained specialist.

3. What are the risks?

Ask about possible complications, including infection, scarring and the need for further treatment.

4. What results can I realistically expect?

Cosmetic procedures can improve appearance but cannot guarantee perfection.

5. What is the recovery process?

Ask about downtime, pain management, activity restrictions and when you can resume normal activities.

6. What will the procedure cost?

Request a breakdown of consultation, hospital, medication and follow-up costs.

7. What if I am unhappy with the results?

Discuss revision policies and corrective options before proceeding.

Children under 15 account for half of the 46 suspected mpox cases in Guinea-Bissau, which declared its first mpox outbreak on July 4, UNICEF said.

As of August 17, the country had reported seven confirmed cases, all among adults. Six were reported in the Autonomous Sector of Bissau and one in the Biombo Region. No deaths have been reported.

Of the 46 suspected cases, 23 are children under 15, including 16 aged 0-4 years. Young children face a greater risk of complications from mpox.

“This is the first time mpox cases have been reported in Guinea-Bissau, making even a small outbreak a major public health event,” said Sandra Martins, UNICEF Deputy Representative in Guinea-Bissau.

“While the country’s surveillance system remains extremely fragile, we face the risk that cases are going undetected, particularly among children who are the most vulnerable to severe complications.”

Concerns Over Undetected Transmission

UNICEF said the confirmed cases do not appear connected, raising concerns about undetected chains of transmission and additional unidentified cases.

Gaps remain in community-based surveillance, including contact identification, sample testing and tracing how the virus is spreading.

Martins urged families to seek care if a child or family member develops a rash, fever, swollen lymph nodes or other symptoms.

What Is Mpox?

Mpox is a viral zoonotic disease that can spread from animals to humans. It is caused by the monkeypox virus, part of the Orthopoxvirus genus, the same family as the variola virus that causes smallpox.

Symptoms of Mpox

Mpox symptoms are generally milder than those of smallpox. After an incubation period of 5 to 21 days, symptoms typically begin with fever, headache, muscle aches and fatigue.

The disease usually resolves within 2 to 4 weeks, but severe cases can occur, particularly in children, pregnant women and immunocompromised people. Common symptoms include:

• Skin rash
• Fever
• Sore throat
• Headache
• Body aches
• Back pain
• Low energy
• Swollen lymph nodes

How Does Mpox Spread?

Mpox can spread through direct contact with the blood, bodily fluids or skin lesions of infected animals, including rodents and primates.

Human-to-human transmission can occur through close contact with respiratory secretions, skin lesions or contaminated objects. The virus can enter through broken skin, the respiratory tract or the mucous membranes of the eyes, nose or mouth.

Mpox: How Can Children Be Protected?

The World Health Organization (WHO) and the Centers for Disease Control and Prevention (CDC) guidelines for preventing mpox transmission include:

• Avoid contact with animals that could harbor the virus, particularly in regions where mpox is endemic.
• Practice good hygiene by washing hands frequently with soap and water or using alcohol-based hand sanitizer.
• Use personal protective equipment (PPE) such as masks, gloves and gowns when caring for infected individuals.
• Isolate infected individuals from others who are at risk of contracting the virus.
• Get vaccinated where available. The smallpox vaccine has been shown to provide some protection against mpox, while newer vaccines specifically designed for mpox are being deployed.

The Centre has tightened restrictions on certain cough and cold medicines for children below four years, citing potential health risks associated with a specific drug combination in children.

The Union Health Ministry has restricted the manufacture, sale and distribution of fixed-dose combinations (FDCs) containing chlorpheniramine maleate and phenylephrine hydrochloride for children under four.

Manufacturers have also been instructed to carry a clear warning stating that the medicine “shall not be used in children below four years of age.”

The decision follows recommendations from an expert committee and the Drugs Technical Advisory Board (DTAB), which reviewed the safety of the combination in young children.

Why These Medicines Have Been Restricted?

Chlorpheniramine is an antihistamine, while phenylephrine is a decongestant. The combination is used to relieve symptoms like blocked or runny nose, sneezing and watery eyes caused by colds, flu and allergies.

However, young children can respond differently to medicines than adults, and dosing errors or adverse effects can result in more serious effects in this age group.

The Health Ministry’s expert committee concluded that the combination could pose potential health risks in children below four, particularly when safer alternatives are available.

The latest directive therefore requires manufacturers to clearly communicate the age restriction rather than putting the onus on parents.

Also read: FSSAI Orders Halt Of Ghee Sales Amid Adulteration Crackdown: How To Spot Fake Ghee & Its Effects On Your Health

Cough And Cold Medicines Are Not Always Needed In Young Children

A common cold is usually caused by a virus, meaning antibiotics do not treat it. In many children, symptoms improve with supportive care such as adequate fluids, rest and measures recommended by a paediatrician.

Combination cough and cold products can contain several active ingredients, increasing the possibility of incorrect dosing and side effects if parents give more than one medicine containing the same ingredient.

This is particularly important for young children because their medication doses are generally calculated according to age and/or body weight.

Also read: Shigellosis Cases In Kerala Raise AMR Concern: All About Complications Due To Drug-Resistant Shigella

Restriction Comes Amid Wider Scrutiny Of Cough Medicines

The government has been tightening oversight of paediatric medicines following serious concerns surrounding cough syrups in India.

In June, the Centre removed cough syrups from an exemption that had allowed certain products to be sold through retail outlets in smaller villages without the same pharmacy restrictions.

What Parents Should Do?

Parents should avoid giving children under four any medicine containing this combination unless specifically advised by a qualified healthcare professional.

• Before giving a cough or cold medicine to a child, parents should:
• Check the active ingredients, not just the brand name.
• Follow the dose prescribed by a paediatrician.
• Avoid combining multiple cold medicines without medical advice.
• Use the measuring device supplied with liquid medicines rather than household spoons.
• Never give a medicine prescribed for another child.
• Seek medical attention if a child’s symptoms are severe, persistent or worsening.

The government has emphasised that safer alternatives are available, while the latest restriction is intended to reduce avoidable medication-related risks in young children.