“I'm not great at the advice. Can I interest you in a sarcastic comment?”

This is what ‘Friends’ actor Matthew Perry’s character Chandler Bing was known for. He was known for being funny. However, he had his own struggles in his personal life and those struggles were acute depression. He was treating it with ketamine infusion therapy which is legal in the US and the UK.

What is Ketamine infusion therapy?

Ketamine is an anaesthetic used to treat depression, anxiety and pain under supervised and controlled medical settings. However, it does have its side effects, which can lead to distortion of sight, sound and time. It can also produce calming and relaxing effects.

Ketamine increases a person’s heart rate and blood pressure. If overdosed, it can leave users confused and agitated and can cause them to hurt themselves without even realising it. It can also lead to liver damage and bladder problems.

However, when used in moderation and under the supervision of medical doctors, it can treat depression where traditional antidepressants have failed.

Prof Rupert McShane, a University of Oxford psychiatrist who runs an NHS ketamine treatment clinic told BBC that ketamine “probably turns off the area of the brain that is involved in disappointment.”

Can Ketamine Infusion Therapy Kill Someone?

In simple terms, it cannot, be if the dosage is given in a controlled setting and as prescribed. Ketamine infusion therapy uses drugs in small doses than those used for anaesthesia. It acts faster than traditional anti-depressants, but the effects also wear off way quickly. Which is why it is important to monitor patients’ mental state for relapsing back into depression and discouraging them from overdosing on it.

There are ways of giving people ketamine. One of the ways is through “infusing”, which means to use an IV drip. However, injections, nasal sprays and capsules are also methods used to give people ketamine.

Since the dosage of ketamine used in the infusion treatment is small, it being the reason of actor Perry’s death was ruled out. The medical examiner also noted that Perry’s last ketamine infusion therapy session happened more than a week before his death, which means by the time he had died, it must have worn off.

So, What Happened To Perry?

Though Perry’s last session was more than a week before, his post-mortem showed that his blood contained a high concentration of ketamine. He had died of the “acute effects” of ketamine.

If it was not his session, then how did he get ketamine?

Prosecutors alleged that his assistant gave him at least 27 shots of ketamine in four days before his death, reported BBC.

Perry has been open about his personal struggles and this is what the doctors and dealers used against him. Martin Estrada, the US attorney for California’s Central District told the BBC that people took advantage of his condition. They charged him 165 times more than what vials of ketamine cost.

Names that have come up include Dr Salvador Plasencia, drug dealers “Ketamine Queen” aka Jasveen Sangha and Eric Fleming, and Perry’s live-in assistant Kenneth Iwamasa.

Who Are These Names And What Did They Do?

Ketamine Queen or Sangha supplied drugs that led to Perry’s death. Her home was a “drug-selling emporium,” said Estrada. More than 80 vials of ketamine, and thousands of pills including methamphetamine, cocaine and Xanax were allegedly found in her house known as the “Sangha Stash House.”

Sangha is known to deal with high-end celebs and was a “major source of supply for ketamine to others as well as Perry,” said Estrada.

Dr Plasencia called Perry a “moron” while charging him $2,000 for vials that cost only $12. He sold Perry 20 vials of ketamine between September and October 2023, costing $55,000.

He was the one who taught Iwamasa, who had no medical knowledge to inject the drug. This is after he knew that “Perry’s ketamine addiction was spiralling out of control,” as per what the investigators told the BBC.

Another dealer Fleming was told by Sangha to “delete all our messages.” While Fleming pleaded guilty to conspiring to distribute drugs unlawfully, he also allegedly messaged Sangha: “Please call...Got more info and want to bounce ideas off you. I’m 90% sure everyone is protected. I never dealt with [Perry] only his assistant. So the assistant was the enabler.”

The court documents also revealed that he asked Sangha on whether the ketamine stays in your system or “is it immediately flushed out.”

Dr Pepper, Bots, Cans

The people who allegedly exploited Perry used coded language for ketamine and called it “Dr Pepper”, “bots”, or “cans.”

Selling overpriced drugs, taking advantage of Perry’s mental condition and falsifying medical records to make the drugs given to him look legitimate by Dr Plasencia is what took Perry’s life.

Iwamasa is said to have administered more than 20 shots of ketamine and three on the day Perry died. Whereas ketamine is only administered by a physician. Authorities also found that weeks before Perry’s death, Dr Plasencia allegedly bought 10 vials of ketamine and intended to sell to Perry.

He also injected Perry with a large dose, two days later. This caused him to “freeze up” and spiked his blood pressure.

When I Die, I Want Helping Others To Be The First Thing That’s Mentioned

Perry had always been open about his drug addictions, struggles with alcohol and his depression. He said that his openness would help others who are also struggling and wanted to be remembered by his quote which also is on the homepage of the Mattew Perry Foundation that helps others struggling with the disease of addiction: “When I die, I want helping others to be the first thing that’s mentioned.”

Five arrests have been made in the case so far.

Heart failure (HF) remains a major global health challenge, affecting more than 64 million adults worldwide.

To improve how the condition is prevented, diagnosed and managed, leading cardiovascular organizations, including the American Heart Association (AHA) and the American College of Cardiology (ACC), have released the "Second Universal Definition of Heart Failure."

The updated definition addresses changes in disease manifestations, diagnostic strategies and the understanding of heart failure's underlying biology. It also aims to establish a unified framework for clinicians, researchers, health systems and policymakers worldwide.

Published on behalf of the ACC, AHA, European Society of Cardiology (ESC) and World Heart Federation (WHF), in collaboration with the Heart Failure Society of America (HFSA), the Heart Failure Association (HFA) of the ESC and the Japanese Heart Failure Society (JHFS), the document updates the First Universal Definition of Heart Failure, released in 2021. It has been published simultaneously in Circulation, Journal of the American College of Cardiology (JACC), European Heart Journal and Global Heart.

What Does The Updated Definition Include?

The prevalence of heart failure continues to rise due to ageing populations and increasing rates of obesity, Type 2 diabetes and high blood pressure.

To better address this growing burden, the new framework introduces several important changes.

• Universal classification of heart failure causes:

• Moving beyond rigid ejection fraction cut-offs:

• Greater emphasis on early detection:

• Recognition that heart failure is dynamic:

• Attention to social and global factors:

Why The New Definition Matters

The revised definition provides a common framework for clinicians, researchers, health systems and policymakers worldwide, helping standardize diagnosis, strengthen research and support more personalized care.

The consensus document will also serve as the foundation for the upcoming American Heart Association/American College of Cardiology Heart Failure Guideline, expected to be published in late 2027.

"Heart failure remains a major challenge that continues to grow globally, and inconsistencies in how it is defined have limited progress in research and treatment. This updated definition provides a clearer, more consistent framework to help clinicians identify risk earlier and guide more personalized treatment approaches that can help improve patient outcomes worldwide," said Mary Norine Walsh, co-chair of the consensus document.

"The new framework recognizes that heart failure is not a static condition. By focusing on stages of disease, underlying causes and disease trajectories—including improvement, remission and recovery—we can better tailor care and advance prevention efforts," she added.

Amid concerns over the ongoing Ebola outbreak in neighboring Democratic Republic of Congo, Sudan has declared a new cholera outbreak, World Health Organization (WHO) Director-General Tedros Adhanom Ghebreyesus announced.

The outbreak has been reported in West Kordofan state.

As of June 20, Sudan's State Ministry of Health had reported 838 suspected cholera cases, seven confirmed cases and 117 deaths.

Conflict Hampering Response

"The outbreak is unfolding amid the continued disruption of health services caused by conflict. Population displacement is making access to essential health care even more difficult. At the same time, insecurity and access constraints continue to delay the deployment of response teams and delivery of medical supplies and humanitarian assistance," Tedros said.

He added that WHO is coordinating the response with partners by scaling up cholera treatment centers and oral rehydration points, delivering cholera kits, installing handwashing stations, training chlorinators, hygiene promoters and health workers, and supporting community health education.

Third Cholera Wave Since 2023

Also Read: Ebola Outbreak Spreads To Fourth Province In DR Congo As Cases Rise To 1,274

Since the conflict began in 2023, Sudan has declared three waves of cholera outbreaks, with the most recent before this one occurring in January 2025 in White Nile State.

The latest announcement comes less than four months after Sudan declared the end of a cholera outbreak that began in July 2024. That outbreak spread across all 18 states, infected more than 124,000 people and claimed 3,573 lives.

According to the health ministry, the outbreak was largely linked to contaminated drinking water after the city's water supply facility was damaged in an attack by paramilitary forces.

War Fueling Disease Spread

Read More: WHO Warns of 70% Risk of Ebola Spread to South Sudan

The combination of conflict, displacement, damaged infrastructure and recurring disease outbreaks has placed millions at risk, with children under five among the most vulnerable.

According to the UNICEF, Sudan's healthcare system is also on the verge of collapse, leaving millions of children at greater risk of infectious diseases. Continued displacement has forced families into overcrowded settlements with limited access to clean water, sanitation and healthcare, creating ideal conditions for cholera and other waterborne diseases to spread.

The outbreaks have been intensified by multiple factors. The war has displaced millions, forcing many into camps with poor sanitation. Health centers, schools and water facilities have been damaged or repurposed as shelters.

Seasonal rains and flooding have further contaminated water sources, accelerating disease transmission.

What Is Cholera?

According to the Centers for Disease Control and Prevention (CDC), it is caused by the bacterium Vibrio cholerae. This can be transmitted through drinking water or eating food that contains the bacteria. While most people who get cholera don't get sick, it can cause life-threatening diarrhea and vomiting.

CDC notes that each year, 1.3 to 4 million people around the world get cholera. Among them, 21,000 to 143,000 people die.

What Are The Common Symptoms?

The common symptoms include:

• watery diarrhea
• vomiting
• leg cramps
• losing body fluids
• dehydration and shock
• Usually, people develop symptoms within 1 to 10 days of consuming the bacteria.

Who Is At More Risk?

People who live in areas with unsafe drinking water, poor sanitation, and inadequate hygiene are at the highest risk of getting cholera. The disease can spread quickly in areas where sewage and drinking water are not adequately treated. It can also live in brackish water, which is slightly salty, or in coastal water. Thus, eating raw shellfish can also cause cholera.

The deadly Ebola virus disease outbreak in the Democratic Republic of Congo (DRC) has spread to a fourth province, raising concerns about wider regional transmission.

Until now, the outbreak had been confined to North Kivu, South Kivu, and the conflict-hit Ituri province, the epicentre of the current outbreak. Cases have also been reported across the border in Uganda.

The virus has now reached Haut-Uele province, which borders South Sudan and the Central African Republic, according to AFP.

WHO Warns Of Regional Spread

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The development also increases the risk of the virus spreading to South Sudan. A new World Health Organization (WHO) modelling study published in The Lancet Infectious Diseases estimates there is a 70 per cent chance the outbreak will reach South Sudan soon.

Haut-Uele province is home to around 15 million people. Health officials said the first case in Haut-Uele was detected after an infected person travelled from Bunia, the capital of Ituri. The patient later died, according to sources at the National Institute of Biomedical Research (INRB).

Cases Climb To 1,274, With 360 Deaths

Confirmed Ebola cases have risen to 1,274, including 360 deaths, according to the WHO.

The DRC declared its 17th Ebola outbreak on May 15. The current outbreak is caused by the Bundibugyo strain of the virus, for which there is currently no approved vaccine or specific treatment.

Clinical trials are expected to begin in the coming days, according to the WHO, which has issued an international alert over the outbreak.

The WHO projections estimate the outbreak could reach about 8,210 cases and 1,420 deaths by mid-September if transmission continues.

Drug Trials Set To Begin

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The first clinical trial of drugs that may treat the Bundibugyo virus is expected to begin in the DRC next week. A separate trial testing an antiviral drug to prevent infection among close contacts is scheduled to start a week later.

Scientists say efforts to develop vaccines and treatments are being hampered by the lack of a viable sample of the Bundibugyo virus.

DRC Restricts Public Gatherings

Separately, Reuters reported on June 29 that the DRC has banned public gatherings in four provinces, including the capital, Kinshasa, as authorities attempt to contain the outbreak.

The ban comes ahead of a planned protest in Kinshasa on July 8 against proposed constitutional reforms. Opposition leaders have described the restriction as "politically motivated."

US CDC Raises Response To Highest Level

Meanwhile, the US Centers for Disease Control and Prevention (CDC) has raised its emergency response to the outbreak to Level 1, its highest activation level. The designation, reserved for the most severe public health emergencies, allows the agency to deploy its maximum response capacity.

Despite the escalation, the CDC said the risk of Ebola spreading to the United States remains low.