“I'm not great at the advice. Can I interest you in a sarcastic comment?”

This is what ‘Friends’ actor Matthew Perry’s character Chandler Bing was known for. He was known for being funny. However, he had his own struggles in his personal life and those struggles were acute depression. He was treating it with ketamine infusion therapy which is legal in the US and the UK.

What is Ketamine infusion therapy?

Ketamine is an anaesthetic used to treat depression, anxiety and pain under supervised and controlled medical settings. However, it does have its side effects, which can lead to distortion of sight, sound and time. It can also produce calming and relaxing effects.

Ketamine increases a person’s heart rate and blood pressure. If overdosed, it can leave users confused and agitated and can cause them to hurt themselves without even realising it. It can also lead to liver damage and bladder problems.

However, when used in moderation and under the supervision of medical doctors, it can treat depression where traditional antidepressants have failed.

Prof Rupert McShane, a University of Oxford psychiatrist who runs an NHS ketamine treatment clinic told BBC that ketamine “probably turns off the area of the brain that is involved in disappointment.”

Can Ketamine Infusion Therapy Kill Someone?

In simple terms, it cannot, be if the dosage is given in a controlled setting and as prescribed. Ketamine infusion therapy uses drugs in small doses than those used for anaesthesia. It acts faster than traditional anti-depressants, but the effects also wear off way quickly. Which is why it is important to monitor patients’ mental state for relapsing back into depression and discouraging them from overdosing on it.

There are ways of giving people ketamine. One of the ways is through “infusing”, which means to use an IV drip. However, injections, nasal sprays and capsules are also methods used to give people ketamine.

Since the dosage of ketamine used in the infusion treatment is small, it being the reason of actor Perry’s death was ruled out. The medical examiner also noted that Perry’s last ketamine infusion therapy session happened more than a week before his death, which means by the time he had died, it must have worn off.

So, What Happened To Perry?

Though Perry’s last session was more than a week before, his post-mortem showed that his blood contained a high concentration of ketamine. He had died of the “acute effects” of ketamine.

If it was not his session, then how did he get ketamine?

Prosecutors alleged that his assistant gave him at least 27 shots of ketamine in four days before his death, reported BBC.

Perry has been open about his personal struggles and this is what the doctors and dealers used against him. Martin Estrada, the US attorney for California’s Central District told the BBC that people took advantage of his condition. They charged him 165 times more than what vials of ketamine cost.

Names that have come up include Dr Salvador Plasencia, drug dealers “Ketamine Queen” aka Jasveen Sangha and Eric Fleming, and Perry’s live-in assistant Kenneth Iwamasa.

Who Are These Names And What Did They Do?

Ketamine Queen or Sangha supplied drugs that led to Perry’s death. Her home was a “drug-selling emporium,” said Estrada. More than 80 vials of ketamine, and thousands of pills including methamphetamine, cocaine and Xanax were allegedly found in her house known as the “Sangha Stash House.”

Sangha is known to deal with high-end celebs and was a “major source of supply for ketamine to others as well as Perry,” said Estrada.

Dr Plasencia called Perry a “moron” while charging him $2,000 for vials that cost only $12. He sold Perry 20 vials of ketamine between September and October 2023, costing $55,000.

He was the one who taught Iwamasa, who had no medical knowledge to inject the drug. This is after he knew that “Perry’s ketamine addiction was spiralling out of control,” as per what the investigators told the BBC.

Another dealer Fleming was told by Sangha to “delete all our messages.” While Fleming pleaded guilty to conspiring to distribute drugs unlawfully, he also allegedly messaged Sangha: “Please call...Got more info and want to bounce ideas off you. I’m 90% sure everyone is protected. I never dealt with [Perry] only his assistant. So the assistant was the enabler.”

The court documents also revealed that he asked Sangha on whether the ketamine stays in your system or “is it immediately flushed out.”

Dr Pepper, Bots, Cans

The people who allegedly exploited Perry used coded language for ketamine and called it “Dr Pepper”, “bots”, or “cans.”

Selling overpriced drugs, taking advantage of Perry’s mental condition and falsifying medical records to make the drugs given to him look legitimate by Dr Plasencia is what took Perry’s life.

Iwamasa is said to have administered more than 20 shots of ketamine and three on the day Perry died. Whereas ketamine is only administered by a physician. Authorities also found that weeks before Perry’s death, Dr Plasencia allegedly bought 10 vials of ketamine and intended to sell to Perry.

He also injected Perry with a large dose, two days later. This caused him to “freeze up” and spiked his blood pressure.

When I Die, I Want Helping Others To Be The First Thing That’s Mentioned

Perry had always been open about his drug addictions, struggles with alcohol and his depression. He said that his openness would help others who are also struggling and wanted to be remembered by his quote which also is on the homepage of the Mattew Perry Foundation that helps others struggling with the disease of addiction: “When I die, I want helping others to be the first thing that’s mentioned.”

Five arrests have been made in the case so far.

"We just saw it, and everyone is freaking out," told one scientists to the Washington Post on account of anonymity on seeing the Centers for Disease Control and Prevention (CDC) update its website backpedaling on the link between vaccines and autism. The said link had long been debunked, however, the Health Secretary Robert F Kennedy Jr. has echoed the thought, and has a long history of critiquing vaccines and linking it to autism.

The agency's website was updated on Thursday and under Autism and Vaccine, it notes: 'The claim "vaccines do not cause autism" is not an evidence-based claim because studies have not ruled out the possibility that infant vaccine cause autism.'

Also Read: After Lancet Links Ultra-Processed Foods to Organ Damage, New Study Ties Them to Bowel Polyps in Women Under 50

The first header reads: 'Vaccine do not cause autism', the reason the header has not been removed is all thanks to an agreement with the chair of the US Senate Health, Education, Labor, and Pension Committee that it would remain on the CDC website, as per the website.

As the Post reported, the scientists did not have any prior information about the changes to the website, neither were they consulted for it. Before the Wednesday update, the CDC website stated that studies have shown that there is "no link" between vaccines and developing autism in infants. The website previously stated that "no links" have been found between any vaccine ingredients and disorders.

Read: CDC Plans Vaccine-Autism Study Despite Scientific Consensus

The CDC's Claim: Autism and Vaccine Link

As per the CDC website, approximately 1 in 2 surveyed parents of autistic children believe vaccines played a role in their child's autism. For this, the CDC cites a 2006 survey published in the Journal of Developmental and Behavioral Pediatrics. The CDC notes that these vaccines are often those that the child receives in the first six months of life, including Diphtheria, tetanus, pertussis (DTaP), Hepatitis B (HepB), Haemophilus influenzae type B (Hib), Poliovirus, inactivated (IPV), and Pneumococcal conjugate (PCV) and one given at or after the first year of life (Measles, mumps, rubella (MMR)).

According to CDC a timeline has been provided that shows the correlation between the prevalence in autism cases and higher doses of the above mentioned vaccines. In 1986, the CDC recommended five infant vaccine doses: two oral polio (OPV) doses and three DTP injections. By 2025, the schedule expanded to include multiple doses of rotavirus, HepB, DTaP, Hib, PCV, IPV, influenza, and, at 12 months, MMR, varicella, and HepA.

Autism rates have risen since the 1980s, and while this trend coincides with an increase in recommended childhood vaccines, correlation alone does not establish causation. Autism is believed to have multiple contributing factors, and some researchers have examined possible environmental links. One study reported a statistical correlation between aluminum adjuvants and autism prevalence.

Read: Fact Check: Does Aluminum In Vaccines Cause Food Allergies As RFK Jr Claims?

While the CDC notes that correlation does not prove causation it also mentions that "it does merit further study".

What Are The Scientists Saying?

“CDC cannot currently be trusted as a scientific voice,” said Demetre Daskalakis, who formerly led the agency’s center responsible for respiratory viruses and immunizations. He resigned in August. “My question is, how language that misrepresents decades of research ended up on a CDC website,” said Debra Houry, the CDC’s former chief medical officer who also resigned in August.

However, the spokesman for the Department of Health and Human Services that oversees the CDC, Andrew Nixon, said, "We are updating the CDC’s website to reflect gold standard, evidence-based science.”

The Origin Of This Vaccine-Autism Theory

This originated from now debunked 1998 study, which was retracted after its author, Andrew Wakefield, was found guilty of professional misconduct and barred from practicing medicine in the UK. Despite decades or research no such link could be proven, however, the claim still continues in the political and public discourse.

Kennedy, who had long been anti-vaxxer, also made numerous claims, even though studies have long debunked this theory.

Many years of extensive study has shown that there is no real connection between vaccines and autism. As per a 2019 study, which was conducted over a decade in Denmark, involving half a million children, confirmed that the measles, mumps and rubella (MMR) vaccine does not increase any risk of autism. Other studies too have confirmed the same, being studied over large sample sizes. It had reinforced the medical consensus that vaccines are safe and essential for public health.

Los Angeles County has recorded its first flu-related death of the season, the LA County Department of Public Health announced Wednesday.

The individual was an “older adult” with pre-existing health conditions. Officials noted that the person had likely not received a flu vaccine for this season, which generally spans from October through May.

Although flu cases are still low in November, health authorities expect the number of infections to rise as holiday travel and indoor gatherings increase.

First Flu Death In LA County

"The LA County Department of Public Health reported Wednesday the first flu-related death of the season in Los Angeles County. “We extend our condolences to the family and loved ones of the deceased. This sad loss underscores the serious risks posed by influenza,” said Dr. Muntu Davis, Los Angeles County health officer, in a news release.

Flu activity remains low for now, but it is anticipated to climb around Thanksgiving and the broader holiday period, when travel and indoor events are more common.

Experts advise getting vaccinated at least two weeks before holiday travel or gatherings, since it takes time for immunity to develop.

They also recommend wearing a properly fitted mask in crowded indoor settings, particularly for households with older adults, children under five, or pregnant women.

Flu Shot Guidelines and Eligibility

The Centers for Disease Control and Prevention (CDC) recommends that everyone aged six months and older receive an annual influenza vaccine, with rare exceptions for specific medical conditions. Annual vaccination is especially important for high-risk groups, including:

• Older adults, particularly those aged 65 and above
• Young children under five, especially under two years
• Pregnant individuals
• People with chronic medical conditions such as asthma, diabetes, or heart disease
• Residents of long-term care facilities

Timing: The ideal time to get a flu shot is before flu activity peaks, usually in early fall. It takes about two weeks after vaccination for the body to build full immunity, so getting vaccinated before holiday travel and gatherings is crucial.

Flu Shot: Types of Vaccines

Several flu vaccines are available, including standard-dose, high-dose for older adults, and nasal spray options for certain age groups. Your healthcare provider can recommend the most appropriate option based on age, health status, and any contraindications.

Flu vaccines are generally safe. Mild side effects like soreness at the injection site, low-grade fever, or fatigue may occur, but serious reactions are extremely rare. Individuals with severe allergies to vaccine components should consult their healthcare provider before vaccination.

Even after vaccination, preventive measures such as frequent handwashing, wearing masks in crowded indoor spaces, and avoiding contact with sick individuals can help reduce flu transmission.

The U.S. Centers for Disease Control and Prevention is promoting a long-debunked theory, suggesting a potential link between vaccines and autism, and claiming that studies supporting this connection “have been ignored by health authorities.”

CDC Pushes Controversial Vaccine-Autism Theory

The disputed theory appeared on a revised section of the CDC’s website under “Autism and Vaccines” on Wednesday. The website now states: “The statement ‘Vaccines do not cause autism’ is not an evidence-based claim. Scientific studies have not ruled out the possibility that infant vaccines contribute to the development of autism.

Also Read: After Lancet Links Ultra-Processed Foods to Organ Damage, New Study Ties Them to Bowel Polyps in Women Under 50

However, this statement has historically been shared by the CDC and other federal health agencies within HHS to prevent vaccine hesitancy.” The agency added that the U.S. Department of Health and Human Services has “launched a thorough review of the causes of autism, including investigations on plausible biological mechanisms and potential causal links.”

It also noted, “This webpage will be updated with gold-standard science.” Prior to Wednesday, the page stated there is “no link” between vaccines and autism, and no vaccine ingredients were connected to the condition, according to archived versions cited by The Washington Post.

CDC Faces Criticism

Another part of the site, “About Vaccines for Your Children,” last updated in August 2024, still asserts, “Scientific studies and reviews continue to show no relationship between vaccines and autism.” Dr. Demetre Daskalakis, a former CDC official who resigned earlier this year as head of the National Center for Immunization and Respiratory Diseases, criticized the changes, saying on X, “The weaponization of the voice of CDC is getting worse. DO NOT TRUST THIS AGENCY. This is a national embarrassment.” Despite the new language, the header “Vaccines do not cause autism” remains due to an agreement with Sen. Bill Cassidy (R-La.), chair of the Senate Health Committee, who cast the deciding vote to advance Health Secretary Robert F. Kennedy Jr.’s nomination to the full Senate floor.

CDC Staff Shocked

The revisions surprised CDC staff, including those overseeing vaccine safety and autism information, leaving them blindsided, according to The Post. “We just saw it, and everyone is freaking out,” one scientist said, as per NBC News.

While the changes could undermine public confidence in vaccines, Kennedy and Trump have historically supported this theory. Both have also warned against Tylenol use during pregnancy, claiming a link to autism, despite large-scale studies disproving any connection.

What Is The Vaccine And Autism Link About?

Autism spectrum disorder, or autism, is a condition that affects the brain, making it challenging for some people to communicate and interact with others. Experts still don’t fully understand what causes it.

The idea that vaccines might play a role largely began with a 1998 study suggesting that the MMR (measles-mumps-rubella) vaccine—or infection with the natural measles virus—could lead to autism. Since then, numerous scientific studies have shown there is no connection between vaccines or any of their ingredients and autism.

The 1998 study itself was later discredited: the research was found to be false, the doctor responsible lost his medical license, and the journal that published the paper retracted it, acknowledging it should never have been published.

Despite strong evidence showing vaccines are safe and effective, some parents still choose to delay or skip vaccinations for their children. This can be very dangerous, as diseases like measles, which vaccines prevent, are still circulating. An unvaccinated child who contracts one of these illnesses can become seriously ill or even die and may also put others at risk.

While mild reactions like a fever or rash can occur after vaccination, the chance of a serious side effect from the MMR or other recommended vaccines is very small compared to the risks of the diseases they protect against.