“I'm not great at the advice. Can I interest you in a sarcastic comment?”

This is what ‘Friends’ actor Matthew Perry’s character Chandler Bing was known for. He was known for being funny. However, he had his own struggles in his personal life and those struggles were acute depression. He was treating it with ketamine infusion therapy which is legal in the US and the UK.

What is Ketamine infusion therapy?

Ketamine is an anaesthetic used to treat depression, anxiety and pain under supervised and controlled medical settings. However, it does have its side effects, which can lead to distortion of sight, sound and time. It can also produce calming and relaxing effects.

Ketamine increases a person’s heart rate and blood pressure. If overdosed, it can leave users confused and agitated and can cause them to hurt themselves without even realising it. It can also lead to liver damage and bladder problems.

However, when used in moderation and under the supervision of medical doctors, it can treat depression where traditional antidepressants have failed.

Prof Rupert McShane, a University of Oxford psychiatrist who runs an NHS ketamine treatment clinic told BBC that ketamine “probably turns off the area of the brain that is involved in disappointment.”

Can Ketamine Infusion Therapy Kill Someone?

In simple terms, it cannot, be if the dosage is given in a controlled setting and as prescribed. Ketamine infusion therapy uses drugs in small doses than those used for anaesthesia. It acts faster than traditional anti-depressants, but the effects also wear off way quickly. Which is why it is important to monitor patients’ mental state for relapsing back into depression and discouraging them from overdosing on it.

There are ways of giving people ketamine. One of the ways is through “infusing”, which means to use an IV drip. However, injections, nasal sprays and capsules are also methods used to give people ketamine.

Since the dosage of ketamine used in the infusion treatment is small, it being the reason of actor Perry’s death was ruled out. The medical examiner also noted that Perry’s last ketamine infusion therapy session happened more than a week before his death, which means by the time he had died, it must have worn off.

So, What Happened To Perry?

Though Perry’s last session was more than a week before, his post-mortem showed that his blood contained a high concentration of ketamine. He had died of the “acute effects” of ketamine.

If it was not his session, then how did he get ketamine?

Prosecutors alleged that his assistant gave him at least 27 shots of ketamine in four days before his death, reported BBC.

Perry has been open about his personal struggles and this is what the doctors and dealers used against him. Martin Estrada, the US attorney for California’s Central District told the BBC that people took advantage of his condition. They charged him 165 times more than what vials of ketamine cost.

Names that have come up include Dr Salvador Plasencia, drug dealers “Ketamine Queen” aka Jasveen Sangha and Eric Fleming, and Perry’s live-in assistant Kenneth Iwamasa.

Who Are These Names And What Did They Do?

Ketamine Queen or Sangha supplied drugs that led to Perry’s death. Her home was a “drug-selling emporium,” said Estrada. More than 80 vials of ketamine, and thousands of pills including methamphetamine, cocaine and Xanax were allegedly found in her house known as the “Sangha Stash House.”

Sangha is known to deal with high-end celebs and was a “major source of supply for ketamine to others as well as Perry,” said Estrada.

Dr Plasencia called Perry a “moron” while charging him $2,000 for vials that cost only $12. He sold Perry 20 vials of ketamine between September and October 2023, costing $55,000.

He was the one who taught Iwamasa, who had no medical knowledge to inject the drug. This is after he knew that “Perry’s ketamine addiction was spiralling out of control,” as per what the investigators told the BBC.

Another dealer Fleming was told by Sangha to “delete all our messages.” While Fleming pleaded guilty to conspiring to distribute drugs unlawfully, he also allegedly messaged Sangha: “Please call...Got more info and want to bounce ideas off you. I’m 90% sure everyone is protected. I never dealt with [Perry] only his assistant. So the assistant was the enabler.”

The court documents also revealed that he asked Sangha on whether the ketamine stays in your system or “is it immediately flushed out.”

Dr Pepper, Bots, Cans

The people who allegedly exploited Perry used coded language for ketamine and called it “Dr Pepper”, “bots”, or “cans.”

Selling overpriced drugs, taking advantage of Perry’s mental condition and falsifying medical records to make the drugs given to him look legitimate by Dr Plasencia is what took Perry’s life.

Iwamasa is said to have administered more than 20 shots of ketamine and three on the day Perry died. Whereas ketamine is only administered by a physician. Authorities also found that weeks before Perry’s death, Dr Plasencia allegedly bought 10 vials of ketamine and intended to sell to Perry.

He also injected Perry with a large dose, two days later. This caused him to “freeze up” and spiked his blood pressure.

When I Die, I Want Helping Others To Be The First Thing That’s Mentioned

Perry had always been open about his drug addictions, struggles with alcohol and his depression. He said that his openness would help others who are also struggling and wanted to be remembered by his quote which also is on the homepage of the Mattew Perry Foundation that helps others struggling with the disease of addiction: “When I die, I want helping others to be the first thing that’s mentioned.”

Five arrests have been made in the case so far.

NHS doctors are now warning people against vitamin D tablets as it may have negative health impacts after a prolonged use or due to overdose. Posting on X, an NHS spokesperson said: "From October to March, we cannot make enough vitamin D from sunlight, so to keep bones and muscles healthy, it is best to take a daily 10 microgram supplement of vitamin D. You can get vitamin D from most pharmacies and retailers."

However, this advice comes with a note of caution.

Tobias Mapulanga, biomedical scientist and co-founder of Repose Healthcare, as reported by Wales Online warned people of the overdose of the vitamin D pills. "As the NHS encourages vitamin D in winter, many people are reaching for bottles in the darker months and accidentally overshooting, then blaming the fallout on seasonal bugs; when constant thirst and needing the loo more often, queasiness, tummy pain or constipation, headaches or brain fog, and new aches or cramps appear soon after increasing your intake or adding sprays or gummies, that points to a supplement backfiring. The stakes are clear: the right amount supports you, but doubling up can turn a well-meant routine into feeling worse rather than better,” he explained.

As per a survey, 42% of adults in the UK take vitamin D supplements, and the NHS England shows at least 42 reports over the two years of high-strength vitamin D given more frequently. In some cases, hospitalization for the treatment of hypercalcaemia also were noted.

Four Signs To Keep An Eye For While Using Vitamin D

Vitamin D Overdose: Feeling Frequently Thirsty And Want To Urinate

If you find yourself feeling thirsty or want to urinate more, it could be because you are taking too much of vitamin D. NHS experts suggest to cut the intake to a single 10 microgram tablet and drop any extras if these symptoms appear.

What happens is that excess vitamin D could disrupt fluid and salt balance in the body and thus you may want to visit the loo a little more. Also, keep hydrating yourself. In case the symptoms persist, go to your GP.

Read: Doctors Advise UK Residents To Take This Daily Supplement Until March

Vitamin D Overdose: Burping Constantly, Feel Nausea And Have A Sour Stomach

If you feel like puking, and are burping constantly, for feel like a sour stomach, then try to take your supplement after a meal. If you are taking gummies or spray, it is the best time to switch to a tablet. This happens because food buffers the supplement in the gut and reduces irritation, whereas sprays and gummies contain sweeteners or flavors that could create problems for some people.

Vitamin D Overdose: Bones And Muscles Hurt

If you feel your muscles are cramping more and bones also ache, it is a red flag. The key to this is to prioritize your fluids, mineral -rich foods, and physical activities.

Excess vitamin D could disturb the minerals muscles rely on. Furthermore, dehydration makes cramping worse. You can improve your hydration, drink water with meals and also include yogurt and leafy greens in your food. Include some exercise or gentle stretching in your schedule.

Vitamin D Overdose: Cannot Think Straight

Excess vitamin D could also make your brain fog or cause headaches. So, when you buy any supplement, make sure you read the label. Choose a product listing only cholecalciferol and simple bulking agents. Take it with food at the same time each day to keep intake steady and gentler on the gut. Experts also suggest leaving combined A+D products behind and only pick simple D3 tablet.

When a child is born, parents must decide whether to vaccinate them against a range of preventable illnesses. While immunisations are not mandatory, health authorities strongly recommend them to protect both individual children and the wider community. Some professions, particularly in healthcare, require certain vaccinations as a condition of work.

UK Childhood Vaccination Rates Are Falling

Since 2022, no childhood vaccine in the UK has reached the World Health Organization’s recommended 95 per cent uptake, which is crucial for safeguarding vulnerable populations. As a result, preventable diseases like measles are making a comeback.

What’s Driving The Decline In Vaccination

Several factors contribute to falling vaccination rates. Parents may worry about safety, distrust healthcare systems, or follow religious or philosophical beliefs, such as preferring “natural immunity.” Access issues, like difficulties booking GP appointments, have also played a role, according to a BBC report. A malfunctioning NHS IT system has left thousands of children without appointment letters for essential vaccines.

NHS Doctor Issues Urgent Reminder

As per Mirror, NHS GP Dr Bhasha Mukherjee has shared a crucial message for parents. “Every parent wants to keep their child safe,” she wrote. “But here’s what the data reveals about the real risks today.” Dr Mukherjee highlighted that fewer children receiving full immunisation is directly linked to a surge in vaccine-preventable diseases. “This isn’t theoretical – it’s happening right now,” she added.

Measles Cases On The Rise

In 2024, confirmed measles cases in the UK jumped to nearly 3,000, compared with just 367 in 2023, marking the highest annual figure since 2012. Most cases were children aged one to four and five to ten, with 710 and 730 cases respectively, according to the UK Health Security Agency. Global data also shows over 10 million measles cases in 2023, a 20 per cent increase from 2022, linked directly to drops in routine vaccination coverage.

Whooping Cough and Other Illnesses Are Also Resurfacing

Pertussis, commonly known as whooping cough, is rising too. In England alone, more than 14,000 lab-confirmed cases were recorded in 2024, including hundreds among infants under three months old – the age group most vulnerable to severe illness. Sadly, several deaths were reported. Other diseases, like polio, are also reappearing in regions where children are missing essential jabs.

Why Vaccines Are Still Crucial

Many parents fear side effects, but Dr Mukherjee emphasised the dangers of avoiding vaccination. “Diseases like measles can lead to pneumonia, brain inflammation, hearing loss, long-term disability, or even death,” she said. “Vaccines aren’t perfect, but high coverage protects the whole community, especially infants and children with weakened immune systems.”

MMR (measles, mumps, rubella) vaccination rates in 2023–24 were 88.9 per cent, far short of the 95 per cent needed to prevent outbreaks. Dr Mukherjee warns that this shortfall is driving a resurgence in these serious illnesses.

Choosing not to vaccinate increases your child’s risk of catching real, rising threats – and contributes to outbreaks that put many other children at risk too,” Dr Mukherjee concluded.

The human heart can grow new cells in damaged areas after suffering from a heart attack, an Australian study shows.

Heart attacks occur when blood flow to the heart is severely reduced or blocked due to a buildup of plaque which is made of fat, cholesterol and other substances in the heart's arteries.

During a heart attack, a lack of blood flow causes the cells and tissue in the heart muscle to die, leading to irreversible damage that can result in serious complications like arrhythmias, heart failure, cardiogenic shock, or cardiac arrest

It is one of the leading causes of death in the country. Four Indians experience a heart attack every minute, with one in four dying of the cause. Experts have also noticed a rising trend of nearly 50 percent of heart attack patients being under the age of 40, with half of all heart attacks in Indian men occurring under 50.

However scientists in Australia have found that organ can regrow new cells to replace the damaged ones after an attack through increased mitosis.

How Does The Heart Regrow Cells?

Until now, the phenomenon of new heart cells growing in scarred areas of the heart had only been seen in mice however, the team made a breakthrough using living heart tissue samples collected from human patients undergoing bypass surgery at Australia’s Royal Prince Alfred Hospital.

The study, published in Circulation Research, found that while sections of the heart remain that had been left scarred following a heart attack, new heart muscle cells were also being produced in the same area through mitosis.

This process involves a parent cell dividing itself to create two genetically identical daughter cells, each with the same number of chromosomes as the parent for growth, repair and replacing old cells in humans.

READ MORE: The 4-Minute Scandinavian Exercise That Can Add 20 Years To Your Lifespan

Robert Hume, a research fellow at the University of Sydney and the study’s first author, said: "Until now we’ve thought that, because heart cells die after a heart attack, those areas of the heart were irreparably damaged, leaving the heart less able to pump blood to the body’s organs.

"In time, we hope to develop therapies that can amplify the heart’s natural ability to produce new cells and regenerate the heart after an attack."

The scientists are yet to discover the exact mechanism between how cells regrow in scarred regions of the heart.

Coronary Artery Disease: The Silent Killer

Coronary artery disease (CAD) is one of the most common illnesses that can cause a heart attack in people. It develops over years and has no clear signs and symptoms apart from a heart attack.

The illness begins due to a buildup of fats, cholesterol and other substances known as plaque in and on the artery walls.

Over time, this can cause narrowing or blockage of the coronary arteries and block the supply of oxygen-rich blood to heart which can lead chest pain (angina), shortness of breath and ultimately, heart attacks.

Typically, those above the age of 45, having a biological family member with heart disease, lack of sleep, smoking, consuming saturated fats along with other autoimmune diseases such as lupus and rheumatoid arthritis can increase the risk of developing CAD.

Nearly one in 10 Indian adults suffer from CAD and about two million people die from the disease annually. Apart from this, about 18 to 20 million American adults aged 20 and older are also affected about the disease.