“I'm not great at the advice. Can I interest you in a sarcastic comment?”

This is what ‘Friends’ actor Matthew Perry’s character Chandler Bing was known for. He was known for being funny. However, he had his own struggles in his personal life and those struggles were acute depression. He was treating it with ketamine infusion therapy which is legal in the US and the UK.

What is Ketamine infusion therapy?

Ketamine is an anaesthetic used to treat depression, anxiety and pain under supervised and controlled medical settings. However, it does have its side effects, which can lead to distortion of sight, sound and time. It can also produce calming and relaxing effects.

Ketamine increases a person’s heart rate and blood pressure. If overdosed, it can leave users confused and agitated and can cause them to hurt themselves without even realising it. It can also lead to liver damage and bladder problems.

However, when used in moderation and under the supervision of medical doctors, it can treat depression where traditional antidepressants have failed.

Prof Rupert McShane, a University of Oxford psychiatrist who runs an NHS ketamine treatment clinic told BBC that ketamine “probably turns off the area of the brain that is involved in disappointment.”

Can Ketamine Infusion Therapy Kill Someone?

In simple terms, it cannot, be if the dosage is given in a controlled setting and as prescribed. Ketamine infusion therapy uses drugs in small doses than those used for anaesthesia. It acts faster than traditional anti-depressants, but the effects also wear off way quickly. Which is why it is important to monitor patients’ mental state for relapsing back into depression and discouraging them from overdosing on it.

There are ways of giving people ketamine. One of the ways is through “infusing”, which means to use an IV drip. However, injections, nasal sprays and capsules are also methods used to give people ketamine.

Since the dosage of ketamine used in the infusion treatment is small, it being the reason of actor Perry’s death was ruled out. The medical examiner also noted that Perry’s last ketamine infusion therapy session happened more than a week before his death, which means by the time he had died, it must have worn off.

So, What Happened To Perry?

Though Perry’s last session was more than a week before, his post-mortem showed that his blood contained a high concentration of ketamine. He had died of the “acute effects” of ketamine.

If it was not his session, then how did he get ketamine?

Prosecutors alleged that his assistant gave him at least 27 shots of ketamine in four days before his death, reported BBC.

Perry has been open about his personal struggles and this is what the doctors and dealers used against him. Martin Estrada, the US attorney for California’s Central District told the BBC that people took advantage of his condition. They charged him 165 times more than what vials of ketamine cost.

Names that have come up include Dr Salvador Plasencia, drug dealers “Ketamine Queen” aka Jasveen Sangha and Eric Fleming, and Perry’s live-in assistant Kenneth Iwamasa.

Who Are These Names And What Did They Do?

Ketamine Queen or Sangha supplied drugs that led to Perry’s death. Her home was a “drug-selling emporium,” said Estrada. More than 80 vials of ketamine, and thousands of pills including methamphetamine, cocaine and Xanax were allegedly found in her house known as the “Sangha Stash House.”

Sangha is known to deal with high-end celebs and was a “major source of supply for ketamine to others as well as Perry,” said Estrada.

Dr Plasencia called Perry a “moron” while charging him $2,000 for vials that cost only $12. He sold Perry 20 vials of ketamine between September and October 2023, costing $55,000.

He was the one who taught Iwamasa, who had no medical knowledge to inject the drug. This is after he knew that “Perry’s ketamine addiction was spiralling out of control,” as per what the investigators told the BBC.

Another dealer Fleming was told by Sangha to “delete all our messages.” While Fleming pleaded guilty to conspiring to distribute drugs unlawfully, he also allegedly messaged Sangha: “Please call...Got more info and want to bounce ideas off you. I’m 90% sure everyone is protected. I never dealt with [Perry] only his assistant. So the assistant was the enabler.”

The court documents also revealed that he asked Sangha on whether the ketamine stays in your system or “is it immediately flushed out.”

Dr Pepper, Bots, Cans

The people who allegedly exploited Perry used coded language for ketamine and called it “Dr Pepper”, “bots”, or “cans.”

Selling overpriced drugs, taking advantage of Perry’s mental condition and falsifying medical records to make the drugs given to him look legitimate by Dr Plasencia is what took Perry’s life.

Iwamasa is said to have administered more than 20 shots of ketamine and three on the day Perry died. Whereas ketamine is only administered by a physician. Authorities also found that weeks before Perry’s death, Dr Plasencia allegedly bought 10 vials of ketamine and intended to sell to Perry.

He also injected Perry with a large dose, two days later. This caused him to “freeze up” and spiked his blood pressure.

When I Die, I Want Helping Others To Be The First Thing That’s Mentioned

Perry had always been open about his drug addictions, struggles with alcohol and his depression. He said that his openness would help others who are also struggling and wanted to be remembered by his quote which also is on the homepage of the Mattew Perry Foundation that helps others struggling with the disease of addiction: “When I die, I want helping others to be the first thing that’s mentioned.”

Five arrests have been made in the case so far.

The COVID-19 pandemic may be over, but its health effects continue to be studied. Now, a new study suggests that SARS-CoV-2 infection may be associated with an increased risk of developing six allergic conditions in children and adults.

The study, published in the Annals of Allergy, Asthma & Immunology, examined the potential burden of allergic diseases following COVID-19 infection among people aged 1 to 64 years.

Which Allergic Conditions Were Linked To COVID?

Researchers conducted a retrospective cohort study using 1:2 propensity-score matching to assess the association between COVID-19 infection and the development of allergic conditions over 18 months.

The study found that COVID-19 infection was associated with an increased risk of six allergic conditions:

• atopic dermatitis,
• asthma,
• food allergy,
• rhinoconjunctivitis,
• medication allergy
• urticaria (hives).

Also read: ‘American Covid’ Strain Drives 50% Surge in UK Hospital Admissions: XFG Symptoms to Know

Among the active-duty subgroup, asthma and rhinoconjunctivitis were significantly associated with previous COVID-19 infection.

Among children, all the conditions except food allergy showed a significant association with infection.

The researchers also found that higher sponsor rank, evaluated as a potential indicator of socioeconomic status, was associated with a slight protective effect against developing asthma.

What's the Link Between COVID And Allergies?

Researchers from the Division of Pulmonary and Sleep Medicine, Department of Pediatrics, University of Washington School of Medicine, said the findings highlight a potential public health burden from allergic diseases following COVID-19 infection.

They emphasized the importance of monitoring for allergic conditions after infection so they can be identified and treated promptly.

The findings could point toward a possible link between SARS-CoV-2 infection and type 2 inflammation, an immune pathway involved in several allergic diseases.

Further, the researchers explained that SARS-CoV-2 was found to disrupt the immune system and affect multiple organs during and after infection.

This was seen early in the pandemic with multisystem inflammatory syndrome in children (MIS-C). Later, long COVID emerged, with symptoms including fatigue, persistent cough, breathlessness, nasal congestion, runny nose and rash.

Read More: CSIR-CCMB Scientists Find Flu & COVID Viruses May Affect A Protein Linked To Parkinson’s Disease

In a blogpost, Dr. Alan Khadavi, an allergy and asthma specialist in Los Angeles, described that several factors could explain the association between COVID-19 and allergic disease. These include

1. Changes In Type 2 Inflammation

SARS-CoV-2 may alter immune regulation and promote type 2 inflammation, an immune pathway involved in several allergic conditions.

2. Mast Cell Activation

COVID-19 may activate mast cells, which release histamine and other inflammatory chemicals. This can contribute to symptoms such as itching, hives, nasal congestion and wheezing.

3. Respiratory Changes

Inflammation in the nose, sinuses and lungs following COVID-19 could potentially make the respiratory system more sensitive to environmental triggers.

4. Increased Indoor Exposure

Pandemic-related lifestyle changes also increased time spent indoors, potentially increasing exposure to dust mites, pets, mold, cockroach allergens and indoor air pollutants.

Can COVID Make Existing Allergies Worse?

Respiratory viruses are known to trigger asthma flare-ups. According to Dr. Khadavi, COVID-19 could add to this risk because immune changes may persist in some people after infection.

However, the study found an association, not causation. Its retrospective design means it cannot prove that COVID-19 directly causes allergic disease or that type 2 inflammation is the underlying mechanism.

Nearly 750,000 eye-care products, including eye drops and ointments, have been recalled over sterility concerns in the US, according to the US FDA.

The recall covers nine products, including more than 500,000 Walgreens-branded lubricant eye-drop units, plus products sold under AvKare, Reliable-1, Cameron Pharmaceuticals, TRP The Relief Products and Major.

The massive recall was initiated in August 2026 by Sterling Pharmaceutical Services LLC, based in Dupo, Illinois. In September, the FDA labeled the recall as a Class II, meaning exposure “may cause temporary or medically reversible adverse health consequences or where the probability of serious adverse health consequences is remote.”

Also read: Nearly 40,000 Bottles Of Popular Eye Drops Recalled Due To Potential Contamination

List of Recalled Eye Care Products

As per the FDA, a total of 747,844 units of the products recalled include:

AvKare

• AvKare Carboxymethylcellulose Sodium Ophthalmic Solution 0.5%, Lubricant Eye Drops, Sterile, 0.5 FL OZ (15 mL) bottle - 12,864 packs
• AvKare Carboxymethylcellulose Sodium Ophthalmic Solution 0.5%, Lubricant Eye Drops, Sterile, 0.5 FL OZ (15 mL) EACH, 1.0 FL OZ (30 mL) TOTAL, 2 count Twin Pack - 107,377 packs.

Reliable -1

• Reliable -1 Laboratories, Sodium Chloride Hypertonicity Ophthalmic Solution, 5%, Sterile, 0.5 FL OZ (15 mL) bottles - 11083 bottles
• Reliable-1 Laboratories Lubricating Tears, Sterile, 0.5 FL OZ (15 mL) bottles - 47616 bottles

Walgreens Lubricant Eye Drops

• Walgreens Lubricant Eye Drops, Carboxymethylcellulose sodium 0.5%, Lubricant Eye Drops, Sterile, 0.5 OZ (15 mL) bottles - 301114 bottles
• Walgreens Lubricant Eye Drops, 0.5 FL OZ (15 mL) 1.0 FL OZ (30 mL) TOTAL, 2 count Twin Pack - 199600 packs.

TRP The Relief Products

• TRP The Relief Products Gentle Eyes Lubricant Eye Drops, Carboxymethylcellulose sodium 0.5%, Sterile Eye Drops, 0.5 FL OZ (15 mL) bottles - 14538 bottles

Major LubriFresh

• Major LubriFresh P.M. Nighttime Ointment, Net wt. 0.125 oz. (3.5 g) tubes -34368 tubes

Lubricant Eye Drops-Cameron Pharmaceuticals

• Lubricant Eye Drops-Cameron Pharmaceuticals, Carboxymethylcellulose Sodium 0.5%, Eye Lubricant, 0.5 FL OZ (15 mL) bottles - 19284 bottles

Why Is Contamination In Eye Drops A Serious Concern?

Read More: FDA Links Lettuce To Cyclospora Outbreak That Infected Almost 13,000: Here's Why Mexico Disputes It

Eye drops are different from other medicines as they are intended to be strictly sterile at all times. The FDA notes that ophthalmic medicines pose a heightened risk because they could bypass some of the body's natural defences.

Contaminated eye drops can introduce microorganisms directly onto the eye and potentially cause infection.

Depending on the type and severity of contamination, an eye infection can cause symptoms ranging from redness and irritation to pain, discharge, vision changes and, in severe cases, serious damage to the eye. This is why sterility is a major safety requirement for ophthalmic products.

This particular recall is based on a potential contamination and lack of assurance of sterility. It does not mean that every bottle is contaminated or that everyone who used the product will develop an infection.

The FDA has not indicated that every user of the recalled product will experience adverse effects. However, consumers who have a recalled bottle should stop using it rather than taking the risk.

What Should You Do If You Have The Recalled Eye Drops?

If you have the recalled bottle of eye drops, check the lot number and expiration date on the packaging. If your bottle matches the recalled product, stop using it.

Consumers should also follow the recall instructions for returning or disposing of the product and can contact a healthcare professional.

The FDA also advises people to stop using eye drops and seek medical advice if they develop eye pain, discharge, changes in vision, or significant discomfort.

The US Food and Drug Administration (FDA) has concluded its investigation into the country’s largest Cyclospora outbreak. It said that there is strong evidence linking the illnesses to recalled shredded iceberg lettuce from Taylor Farms de Mexico. But Mexico is disputing how conclusive that finding is.

The outbreak sickened 12,883 people across 21 US states, according to the FDA. The agency said its investigation found environmental evidence of Cyclospora at locations where the lettuce was grown and processed, although it could not determine exactly how the contamination occurred.

FDA's Investigation

The FDA conducted inspections and collected samples from several iceberg lettuce farms and a processing facility in Mexico.

Two environmental samples tested positive for Cyclospora. One came from a tank containing wastewater at the Taylor Farms de Mexico processing facility, while the other was collected from a drainage ditch at an iceberg lettuce grower identified during the agency’s traceback investigation.

The FDA said these findings, together with epidemiological and traceback data, provided strong evidence connecting the outbreak to recalled shredded iceberg lettuce from Taylor Farms de Mexico.

However, the agency acknowledged that there was not enough evidence to conclusively establish how the lettuce became contaminated.

Mexico Dispute's FDA Claims

Also read: Biggest Cyclospora Outbreak In US Ends: After 13,000 Sick & 2 Dead, Lettuce Contamination Mystery Remains

Mexico's Health Ministry said the FDA investigation did not conclusively identify the source of contamination.

Mexico's food-safety regulator, Cofepris, said testing by its national reference laboratory found no Cyclospora in raw materials, finished products or water from the facility investigated in connection with the outbreak.

Cofepris also argued that environmental findings alone cannot prove that agricultural products were the source of the infections.

In other words, Mexico is not necessarily disputing that Cyclospora was detected in the environment. Rather, it is questioning whether those findings establish that contaminated lettuce was the source of the outbreak.

What Does The FDA Say?

Also read: Broccoli Sprouts Linked To Salmonella Outbreak In US: 22 Cases Reported, FDA Says

The FDA's says that the environmental findings should be considered alongside the other evidence. The agency said the positive samples demonstrate that Cyclospora was present in the environment where the lettuce was grown and processed.

Combined with epidemiological data and findings from traceback, this supports the link to recalled lettuce from Taylor Farms de Mexico.

The FDA has also said it remains confident that all recalled iceberg lettuce connected to this outbreak has been removed from the US market.

How Did The Outbreak Begin?

Also read: Popular Potato Chips Brand Recalled, Classified Under Highest FDA Risk Level Over Salmonella Contamination

The investigation initially focused on people who had reported eating shredded iceberg lettuce, including lettuce served at Taco Bell locations.

By July, FDA traceback investigators had identified Taylor Farms de Mexico as a common supplier of shredded iceberg lettuce associated with affected locations. The company subsequently recalled iceberg lettuce sourced from central Mexico.

The CDC declared the outbreak over on September 11, although the FDA continued investigating how contamination occurred.

What Is Cyclospora?

Cyclospora is a parasite that causes cyclosporiasis, an intestinal infection usually acquired by consuming contaminated food or water.

It can cause prolonged diarrhoea, stomach cramps, nausea, fatigue and weight loss. Symptoms can persist or return if the infection is not treated.

The scale of the outbreak in the US was massive. Before 2026, the largest recorded US cyclosporiasis season occurred in 2019, with around 4,700 illnesses documented nationwide. This single outbreak alone resulted in nearly three times that number.

At its peak, more than 1,000 infections were reported in a single day before the recall. By August, infections had fallen to fewer than two per day on average, after which the CDC determined that the outbreak was over.

The FDA now says it is confident that all recalled iceberg lettuce linked with this outbreak has been removed from the market.