“I'm not great at the advice. Can I interest you in a sarcastic comment?”

This is what ‘Friends’ actor Matthew Perry’s character Chandler Bing was known for. He was known for being funny. However, he had his own struggles in his personal life and those struggles were acute depression. He was treating it with ketamine infusion therapy which is legal in the US and the UK.

What is Ketamine infusion therapy?

Ketamine is an anaesthetic used to treat depression, anxiety and pain under supervised and controlled medical settings. However, it does have its side effects, which can lead to distortion of sight, sound and time. It can also produce calming and relaxing effects.

Ketamine increases a person’s heart rate and blood pressure. If overdosed, it can leave users confused and agitated and can cause them to hurt themselves without even realising it. It can also lead to liver damage and bladder problems.

However, when used in moderation and under the supervision of medical doctors, it can treat depression where traditional antidepressants have failed.

Prof Rupert McShane, a University of Oxford psychiatrist who runs an NHS ketamine treatment clinic told BBC that ketamine “probably turns off the area of the brain that is involved in disappointment.”

Can Ketamine Infusion Therapy Kill Someone?

In simple terms, it cannot, be if the dosage is given in a controlled setting and as prescribed. Ketamine infusion therapy uses drugs in small doses than those used for anaesthesia. It acts faster than traditional anti-depressants, but the effects also wear off way quickly. Which is why it is important to monitor patients’ mental state for relapsing back into depression and discouraging them from overdosing on it.

There are ways of giving people ketamine. One of the ways is through “infusing”, which means to use an IV drip. However, injections, nasal sprays and capsules are also methods used to give people ketamine.

Since the dosage of ketamine used in the infusion treatment is small, it being the reason of actor Perry’s death was ruled out. The medical examiner also noted that Perry’s last ketamine infusion therapy session happened more than a week before his death, which means by the time he had died, it must have worn off.

So, What Happened To Perry?

Though Perry’s last session was more than a week before, his post-mortem showed that his blood contained a high concentration of ketamine. He had died of the “acute effects” of ketamine.

If it was not his session, then how did he get ketamine?

Prosecutors alleged that his assistant gave him at least 27 shots of ketamine in four days before his death, reported BBC.

Perry has been open about his personal struggles and this is what the doctors and dealers used against him. Martin Estrada, the US attorney for California’s Central District told the BBC that people took advantage of his condition. They charged him 165 times more than what vials of ketamine cost.

Names that have come up include Dr Salvador Plasencia, drug dealers “Ketamine Queen” aka Jasveen Sangha and Eric Fleming, and Perry’s live-in assistant Kenneth Iwamasa.

Who Are These Names And What Did They Do?

Ketamine Queen or Sangha supplied drugs that led to Perry’s death. Her home was a “drug-selling emporium,” said Estrada. More than 80 vials of ketamine, and thousands of pills including methamphetamine, cocaine and Xanax were allegedly found in her house known as the “Sangha Stash House.”

Sangha is known to deal with high-end celebs and was a “major source of supply for ketamine to others as well as Perry,” said Estrada.

Dr Plasencia called Perry a “moron” while charging him $2,000 for vials that cost only $12. He sold Perry 20 vials of ketamine between September and October 2023, costing $55,000.

He was the one who taught Iwamasa, who had no medical knowledge to inject the drug. This is after he knew that “Perry’s ketamine addiction was spiralling out of control,” as per what the investigators told the BBC.

Another dealer Fleming was told by Sangha to “delete all our messages.” While Fleming pleaded guilty to conspiring to distribute drugs unlawfully, he also allegedly messaged Sangha: “Please call...Got more info and want to bounce ideas off you. I’m 90% sure everyone is protected. I never dealt with [Perry] only his assistant. So the assistant was the enabler.”

The court documents also revealed that he asked Sangha on whether the ketamine stays in your system or “is it immediately flushed out.”

Dr Pepper, Bots, Cans

The people who allegedly exploited Perry used coded language for ketamine and called it “Dr Pepper”, “bots”, or “cans.”

Selling overpriced drugs, taking advantage of Perry’s mental condition and falsifying medical records to make the drugs given to him look legitimate by Dr Plasencia is what took Perry’s life.

Iwamasa is said to have administered more than 20 shots of ketamine and three on the day Perry died. Whereas ketamine is only administered by a physician. Authorities also found that weeks before Perry’s death, Dr Plasencia allegedly bought 10 vials of ketamine and intended to sell to Perry.

He also injected Perry with a large dose, two days later. This caused him to “freeze up” and spiked his blood pressure.

When I Die, I Want Helping Others To Be The First Thing That’s Mentioned

Perry had always been open about his drug addictions, struggles with alcohol and his depression. He said that his openness would help others who are also struggling and wanted to be remembered by his quote which also is on the homepage of the Mattew Perry Foundation that helps others struggling with the disease of addiction: “When I die, I want helping others to be the first thing that’s mentioned.”

Five arrests have been made in the case so far.

The National Pharmaceutical Pricing Authority (NPPA) has capped trade margins on 137 non-scheduled anti-cancer drugs at 30%. The move is expected to reduce the maximum retail prices (MRPs) of the cancer medicines by up to 70%.

Announced by the Department of Pharmaceuticals under the Ministry of Chemicals and Fertilizers, the measure aims to curb excessive mark-ups in the distribution and sale of cancer medicines.

It covers a range of anti-cancer drugs, including patented treatments, and is intended to ease the financial burden on patients and their families.

The revised prices is reported to come into effect on November 9, 2026. Manufacturers have been directed to submit revised prices to the NPPA within seven days of the notification.

Indian Government Caps Trade Margins On Cancer Drugs

Also read: Dr Rachna Shroff: Indian-American Cancer Researcher Who Turned Her Diagnosis Into Advocacy

Trade margins are the difference between the price at which a medicine enters the distribution chain and the price charged as it moves further along that chain. These margins reflect in the final cost of the medicines to the patients.

According to the government, an analysis of market data found that non-scheduled anti-cancer medicines had an average trade mark-up of around 170%, some even reaching as high as 700%.

Non-scheduled medicines are drugs that do not fall under the scheduled list of medicines subject to specific ceiling prices under the Drug Price Control Order.

The latest intervention uses the government's powers under Paragraph 19 of the Drugs (Prices Control) Order, 2013, to cap trade margins in the affordable healthcare in serious illnesses like cancer.

By limiting these margins, the government expects to bring down prices of these medicines and help patients to avoid switching to different medicines solely because of cost.

The list includes 137 non-scheduled anti-cancer drugs recommended by an expert committee under the Directorate General of Health Services (DGHS). The committee included oncologists, medical specialists, hospital experts and government officials. The medicines covered include pembrolizumab, ribociclib and abemaciclib, which are used in the management of certain cancers. Other medicines on the list include atezolizumab and bevacizumab.

Expected Savings Of Nearly ₹2,500 Crore For Patients

Also read: H. pylori And Cancer: US Gastroenterologist Explains How A Common Stomach Infection Raises Risk

With this measure, the government expects to generate annual savings of approximately ₹2,500 crore for patients. The expected reduction in MRP ranges roughly from 20% to 70%, depending on the medicine.

This is not the first the government has intervened in the pricing of anti-cancer drugs. In 2019, trade margins on 42 anti-cancer drugs were capped at 30%. After that, the MRPs of 526 brands of non-scheduled anti-cancer medicines were reduced by up to 90%, which generated annual estimated annual savings of ₹984 crore.

The latest measure expands the rule to a larger group of medicines to improve affordability and better access to cancer treatment.

NPPA's Directives To Drug Manufacturers

The NPPA has asked drug manufacturers to submit revised MRPs within seven days of the announcement and make the updated prices available through their websites, hospital pharmacies and retailers.

From November 9, hospitals and pharmacies must sell the cancer medicines at the revised prices without fail. Hospitals and retailers who sell anti-cancer medicines in substantial amounts everyday have specifically been asked to comply with the notification.

The government has also asked manufacturers to maintain production and supply levels to prevent shortages after the price changes. State drug controllers will monitor compliance among manufacturers, distributors, retailers and healthcare institutions.

Patients must confirm the exact brand, strength and formulation prescribed, as prices can differ across products from November 9. They should not change or discontinue cancer treatment on their own without consulting their oncologist.

A Yakima County resident in Washington has tested positive for avian influenza after exposure to infected dairy cattle, the Yakima Health District (YHD) and Washington State Department of Health (DOH) announced.

The resident has not developed severe illness, has not required hospitalization and is isolating at home, officials said.

“We are working closely with our public health partners to follow up with people who have been in close contact with this individual. We want to make sure they know what symptoms to watch for and can access testing and treatment if needed,” said Dr. Dave Atteberry, health officer at the Yakima Health District.

H5N1 Detected In Washington Dairy Cattle

The case follows the detection of highly pathogenic avian influenza (HPAI) H5N1 in dairy cattle on two Yakima County farms. The resident was exposed to the infected cattle.

The Washington State Department of Agriculture has placed both farms under quarantine and implemented biosecurity measures, officials said. Veterinarians are treating sick cows.

Washington State Veterinarian Amber Itle urged farms to strengthen biosecurity measures and promptly report symptoms in animals.

Also read: H5N1 Bird Flu Reaches New Zealand; 12 Human Infections Reported Worldwide

Should You Be Worried About Bird Flu?

The risk to the general public remains low, health officials said. Dairy workers and others who have close or prolonged contact with infected animals or contaminated environments face a higher risk.

Public health officials are contacting people who had close contact with the patient and monitoring them for symptoms for 14 days after their last exposure.

Have Human Bird Flu Cases Been Reported Before In The US?

Read More: H5 Bird Flu Spreads To Australian Mammals: Is It Nearing Humans?

Yes. The first reported human H5N1 case in the US was detected in April 2022 in a Colorado poultry worker exposed to infected birds. The first presumed cow-to-human H5N1 transmission in the country was reported in Texas in April 2024, involving a dairy worker exposed to infected cattle.

According to the Pan American Health Organization (PAHO), 1,002 laboratory-confirmed human H5N1 infections and 479 deaths were reported across 25 countries between 2003 and August 7, 2026. In 2026 alone, nine cases, including two deaths, were reported worldwide.

The US Centers for Disease Control and Prevention (CDC) reported 12 human H5N1 infections outside the US between August 4, 2025, and June 10, 2026: eight in Cambodia, three in Bangladesh and one in India. Three cases were fatal. The infections were associated with exposure to infected poultry or their environments; no person-to-person transmission was identified.

What Is Avian Influenza?

Avian influenza, commonly called bird flu, is caused by Type A influenza viruses found naturally in wild birds. The virus can spread to poultry and mammals, including dairy cattle. Humans can become infected through close contact with infected animals or contaminated environments.

Sustained human-to-human transmission of currently circulating H5N1 viruses has not been established.

How Can You Reduce Your Risk?

People who have close or prolonged contact with infected animals or contaminated environments face a higher risk. They include agricultural workers, backyard flock owners, hunters and wildlife workers.

To prevent the risk, it is recommended to:

• Avoid touching wild birds or other animals, including those that appear healthy. Stay away from sick or dead animals, bird droppings and potentially contaminated surfaces.
• Workers exposed to infected animals should follow recommended precautions, wear appropriate personal protective equipment (PPE) and report suspected illness in animals.
• Hunters should wear disposable gloves when handling harvested birds and practice good hygiene.
• Ask your healthcare provider about seasonal flu vaccination. It does not prevent bird flu but can reduce the risk of simultaneous infection with human and avian influenza viruses.

Are Dairy Products Safe To Consume?

Pasteurization kills HPAI viruses in milk, helping protect the commercial dairy supply. However, infected cows can shed the virus in their milk, making raw milk and unpasteurized dairy products unsafe.

Avoid raw dairy products. Do not give pets raw milk, unpasteurized dairy products or raw meat.

Female high school students in the United States had lower overall cardiovascular health scores than male students, with mean scores of 64.2 and 66.2, respectively, according to a nationwide survey by the US Centers for Disease Control and Prevention (CDC).

The findings, based on the American Heart Association’s Life’s Essential 8 framework, showed that female students had lower mean scores for physical activity and sleep health but higher, more favorable BMI scores than male students.

Lower physical activity and sleep health scores were also observed among students in higher grades, while nicotine exposure scores were lower among students in higher grades.

CDC Study Assesses Heart Health Among US Teenagers

Also read: 4 in 10 US High School Students Report Binge Eating: What Are the Risks?

The 2025 biennial Youth Risk Behavior Survey included 10,710 students in grades 9–12. Of these, 5,192 had complete data for all five cardiovascular health measures: physical activity, diet, sleep health, body mass index (BMI), and nicotine exposure.

The findings, published in the CDC’s Morbidity and Mortality Weekly Report, showed that approximately 21% of students had high overall cardiovascular health scores, while 61% had moderate scores and 18% had low scores.

The prevalence of high overall scores was lower among female students and those in grades 10–12 than among male students and ninth-graders, respectively. Overall, approximately four in five students had low or moderate scores across the five assessed cardiovascular health measures.

Why Sleep, Diet and Exercise Matter for Teen Heart Health

Read More: The Silent Struggle Of Raising A Child With Mental Health Challenges: How Parents Can Cope With Stigma

Cardiovascular diseases (CVDs) are the leading causes of mortality in the US, and many CVD risk factors emerge in childhood and adolescence. Adolescence is a crucial period during which health behaviors develop and persist into adulthood.

A March 2026 study published in the European Journal of Preventive Cardiology suggested that even small, combined improvements in daily habits may benefit cardiovascular health.

Sleeping an additional 11 minutes, engaging in five more minutes of moderate-to-vigorous physical activity, and eating an extra quarter-cup of vegetables daily were associated with a 10% lower risk of heart attacks, strokes and other serious cardiovascular problems compared with less healthy habits.

Sleep is particularly important during adolescence, when the body and brain undergo significant developmental changes. Adequate sleep supports physical recovery, immune function, concentration and emotional well-being.

Teenagers generally need eight to 10 hours of sleep each night. However, schoolwork, extracurricular activities and screen time can interfere with sufficient rest. Research has also linked insufficient sleep with less healthy food choices and a greater tendency to eat later at night.

Elsie Taveras, a pediatrician at Mass General Brigham, highlights the importance of adequate sleep in reducing the risk of chronic conditions, including obesity and cardiovascular risk factors. Children from racial minority and lower-income households may face additional barriers to healthy sleep.

“Sleep health is something we need to pay attention to, and that we counsel teenagers and their families about,” Taveras said.

“We’ve found that shorter sleep duration and lower sleep quality in children and adolescents are associated with a higher risk of obesity and risk factors for heart disease. These are substantial effects that can affect children for years to come,” she added.