“I'm not great at the advice. Can I interest you in a sarcastic comment?”

This is what ‘Friends’ actor Matthew Perry’s character Chandler Bing was known for. He was known for being funny. However, he had his own struggles in his personal life and those struggles were acute depression. He was treating it with ketamine infusion therapy which is legal in the US and the UK.

What is Ketamine infusion therapy?

Ketamine is an anaesthetic used to treat depression, anxiety and pain under supervised and controlled medical settings. However, it does have its side effects, which can lead to distortion of sight, sound and time. It can also produce calming and relaxing effects.

Ketamine increases a person’s heart rate and blood pressure. If overdosed, it can leave users confused and agitated and can cause them to hurt themselves without even realising it. It can also lead to liver damage and bladder problems.

However, when used in moderation and under the supervision of medical doctors, it can treat depression where traditional antidepressants have failed.

Prof Rupert McShane, a University of Oxford psychiatrist who runs an NHS ketamine treatment clinic told BBC that ketamine “probably turns off the area of the brain that is involved in disappointment.”

Can Ketamine Infusion Therapy Kill Someone?

In simple terms, it cannot, be if the dosage is given in a controlled setting and as prescribed. Ketamine infusion therapy uses drugs in small doses than those used for anaesthesia. It acts faster than traditional anti-depressants, but the effects also wear off way quickly. Which is why it is important to monitor patients’ mental state for relapsing back into depression and discouraging them from overdosing on it.

There are ways of giving people ketamine. One of the ways is through “infusing”, which means to use an IV drip. However, injections, nasal sprays and capsules are also methods used to give people ketamine.

Since the dosage of ketamine used in the infusion treatment is small, it being the reason of actor Perry’s death was ruled out. The medical examiner also noted that Perry’s last ketamine infusion therapy session happened more than a week before his death, which means by the time he had died, it must have worn off.

So, What Happened To Perry?

Though Perry’s last session was more than a week before, his post-mortem showed that his blood contained a high concentration of ketamine. He had died of the “acute effects” of ketamine.

If it was not his session, then how did he get ketamine?

Prosecutors alleged that his assistant gave him at least 27 shots of ketamine in four days before his death, reported BBC.

Perry has been open about his personal struggles and this is what the doctors and dealers used against him. Martin Estrada, the US attorney for California’s Central District told the BBC that people took advantage of his condition. They charged him 165 times more than what vials of ketamine cost.

Names that have come up include Dr Salvador Plasencia, drug dealers “Ketamine Queen” aka Jasveen Sangha and Eric Fleming, and Perry’s live-in assistant Kenneth Iwamasa.

Who Are These Names And What Did They Do?

Ketamine Queen or Sangha supplied drugs that led to Perry’s death. Her home was a “drug-selling emporium,” said Estrada. More than 80 vials of ketamine, and thousands of pills including methamphetamine, cocaine and Xanax were allegedly found in her house known as the “Sangha Stash House.”

Sangha is known to deal with high-end celebs and was a “major source of supply for ketamine to others as well as Perry,” said Estrada.

Dr Plasencia called Perry a “moron” while charging him $2,000 for vials that cost only $12. He sold Perry 20 vials of ketamine between September and October 2023, costing $55,000.

He was the one who taught Iwamasa, who had no medical knowledge to inject the drug. This is after he knew that “Perry’s ketamine addiction was spiralling out of control,” as per what the investigators told the BBC.

Another dealer Fleming was told by Sangha to “delete all our messages.” While Fleming pleaded guilty to conspiring to distribute drugs unlawfully, he also allegedly messaged Sangha: “Please call...Got more info and want to bounce ideas off you. I’m 90% sure everyone is protected. I never dealt with [Perry] only his assistant. So the assistant was the enabler.”

The court documents also revealed that he asked Sangha on whether the ketamine stays in your system or “is it immediately flushed out.”

Dr Pepper, Bots, Cans

The people who allegedly exploited Perry used coded language for ketamine and called it “Dr Pepper”, “bots”, or “cans.”

Selling overpriced drugs, taking advantage of Perry’s mental condition and falsifying medical records to make the drugs given to him look legitimate by Dr Plasencia is what took Perry’s life.

Iwamasa is said to have administered more than 20 shots of ketamine and three on the day Perry died. Whereas ketamine is only administered by a physician. Authorities also found that weeks before Perry’s death, Dr Plasencia allegedly bought 10 vials of ketamine and intended to sell to Perry.

He also injected Perry with a large dose, two days later. This caused him to “freeze up” and spiked his blood pressure.

When I Die, I Want Helping Others To Be The First Thing That’s Mentioned

Perry had always been open about his drug addictions, struggles with alcohol and his depression. He said that his openness would help others who are also struggling and wanted to be remembered by his quote which also is on the homepage of the Mattew Perry Foundation that helps others struggling with the disease of addiction: “When I die, I want helping others to be the first thing that’s mentioned.”

Five arrests have been made in the case so far.

President Trump's noticeably raspy voice drew attention during a meeting with the White House task force on the FIFA World Cup 2026 on Monday, when a reporter asked if he was feeling well. Trump replied, "I feel great. I was shouting at people because they were being foolish about something related to trade and a country, and I straightened it out, but I lost my temper with them." This has reignited discussions about Donald Trump's health.

President Trump’s Unusually Hoarse Voice at Press Conference Sparks Health Concerns

Trump’s hoarse voice caught attention as he explained it came from raising his voice at foreign leaders over his favorite topic: trade and tariffs. He sounded a bit rough during a November 17 Oval Office event, where he spoke to reporters about the U.S. hosting plans for the 2026 FIFA World Cup, as per USA Today.

"I feel great," Trump said when asked about his raspy tone. "I was shouting at people because they were stupid about something to do with trade in a country, and I fixed it. But I lost my temper with them." He added, "A country tried to renegotiate the terms of their trade deal, and I wasn’t happy." When pressed on which country, Trump refused to answer, saying, "Why would I say that to you?"

Donald Trump Health Concerns

Trump’s health has been under the microscope during his second term, particularly dark spots noticed on his hand, which he attributes to taking aspirin regularly and frequent handshakes. The White House reported he recently had an MRI as part of his annual physical, which Trump described as “standard,” though he admitted he did not know what exactly the doctors were reviewing, as per USA Today.

Earlier this year, it was also disclosed that Trump was diagnosed with a common vein condition, usually not serious with treatment, after he was seen with swollen ankles. At 79, Trump continues to insist his health is excellent.

Donald Trump MRI Scan Controversy

Trump revealed he had an MRI scan, saying the doctor called it the “best result” they had ever seen in their career. When asked which part of his body was examined, he clarified that it was all part of a “routine annual” physical. “I had no idea what they analyzed, but whatever they analyzed, they analyzed it well,” he said.

In October, Trump told reporters he underwent an MRI at Walter Reed National Military Medical Center during a “very standard” checkup, describing it as routine. When asked if it involved his brain, he said, “Getting an MRI is very standard. What, you think I shouldn’t have it? Other people get it … I had an MRI. The doctor said it was the best result he has ever seen as a doctor.”

While traveling on Air Force One to Florida, the president added, “The other thing I did … as you know … was a very advanced test on mental acuity because I believe a president should do that, and as you probably heard, I aced it.”

Journalist Mehdi Hasan reacted on X, saying: “Donald Trump says he does not know why he had an MRI. How is this not 25th Amendment territory?”

MSNBC co-host Symone D. Sanders Townsend also wrote on X Friday: “This is not routine. Why did the President need an MRI?”

As this marked Trump’s second MRI, questions have emerged about his health. Initially, the White House described his visit to Walter Reed as a “routine yearly checkup,” even though he had already had his yearly physical in April. The president later referred to it as a “semiannual physical.”

The FDA on Friday revised the safety information for Sarepta Therapeutics’ Duchenne muscular dystrophy gene therapy, Elevidys, adding a boxed warning to alert patients and doctors about the risk of severe liver damage and possible death. This highest-level warning outlines the chance of serious liver injury and acute liver failure in people who receive Elevidys, with both complications carrying the possibility of being fatal.

The agency has also limited the therapy’s use to ambulatory Duchenne patients who are at least 4 years old and have a confirmed mutation in the DMD gene. With these changes, Elevidys is no longer permitted for patients who cannot walk.

What Is Duchenne Muscular Dystrophy?

Duchenne muscular dystrophy (DMD) is a serious inherited condition that leads to steady muscle weakening and loss, affecting boys far more often. It stems from a defect in the dystrophin gene, which prevents the body from making a key protein that protects muscle fibers.

Signs usually show up in early childhood and include trouble walking or climbing, frequent falls and a noticeable waddling walk, according to the Cleveland Clinic.

What Is The Duchenne Gene Therapy?

Gene therapy for Duchenne muscular dystrophy delivers a corrected or shortened form of the dystrophin gene into muscle cells using a modified virus. This allows the cells to produce a working version of the protein. The single intravenous infusion is designed to slow the disease by restoring some dystrophin, with the aim of improving movement and daily functioning. While the FDA has cleared a therapy that creates a reduced “micro-dystrophin,” researchers are still working on ways to provide the full-length gene for potentially stronger results, as noted by the Food and Drug Administration.

What Is Elevidys?

Elevidys is a gene-based treatment designed for Duchenne muscular dystrophy. It is given only once and relies on an adeno-associated virus to carry a modified form of the dystrophin gene into the body. This shorter micro-dystrophin version is meant to take the place of the faulty or absent dystrophin that leads to the condition.

FDA Tightens Duchenne Gene Therapy After Deaths Of Two Teens

The U.S. Food and Drug Administration is tightening control over a Duchenne muscular dystrophy gene therapy after two teenagers died from liver failure linked to the treatment. The agency has restricted Elevidys, made by Sarepta Therapeutics, to boys aged 4 and older who are still able to walk.

It can no longer be given to boys who have already lost the ability to move independently, something that usually occurs around age 12 in Duchenne. A safety review confirmed that both teenagers developed severe liver damage after receiving the infusion and later died.

The FDA is also adding its strongest boxed warning to call attention to the risks of serious liver injury, acute liver failure and death. Sarepta, based in Cambridge, Massachusetts, with offices in several countries, told regulators earlier this year that it had already stopped supplying the therapy to non-ambulatory patients. The company stated that Elevidys has been used in 1,100 patients worldwide.

These updates “will ensure that families and health-care professionals have clear information” to support treatment choices, Louise Rodino-Klapac, Sarepta’s head of research and development, told The New York Times.

The FDA’s new label comes at the end of a difficult year for Sarepta, marked by weak clinical trial results, safety questions surrounding Elevidys and declining sales.

Liev Schreiber, American actor, best known for his role in Spotlight, and latest seen at the Stranger Things promotional events alongside his daughter Kai Schreiber, was rushed to hospital on Sunday. The actor said that he was suffering from a "brutal headache".

The TMZ reported the health scare after he was being hospitalized in the New York City, and stayed overnight Sunday in the hospital on the advice of his doctor. The doctors have also run tests on him. However, his diagnosis still remains unclear, though as per the TMZ report, doctors have said to him that his ability to walk and speech has not be affected.

Liev Schreiber Health Scare In Past

In April 2024, Schreiber revealed that he had a rare condition called transient global amnesia, while he was starring in Doubt: A Parable on Broadway during an appearance on Late Night with Seth Meyers.

“The worst nightmare that an actor could possibly ever experience. I was in my dressing room and I had a terrible headache. I thought it was maybe a fast-food headache, but it felt a little stronger than that. I am walking down the stairs, and I am thinking, 'This is not normal. I don't feel okay'," he said.

He said that his condition got worse when he was on stage, as he would completely forget his lines. "It all vanishes. The play is gone from my head...I know I am in a play, but I do not know what play I am in," he said.

He added, "My doctor, who’s a friend, shows up, and he had a terrified expression. My wife shows up, and she looks terrified. I think, ‘Okay, I’ve had a stroke. This is it.'” Although it was not a stroke, but the symptom of transient global amnesia, the actor did not believe it.

He recalled the doctor telling him that he may have the same experience again "it will be gone in 8 to 24 hours", however, he did not believe it. "You know, as a typical sort of Jewish hypochondriac person, I’m convinced that I had a stroke and they just didn’t find it," he said.

“I go to sleep, I wake up, I remember the whole play. I never had another problem with it. I was embarrassed and thought everyone would think I was lying and taking a night off from the theater,” he added.

What Is Transient Global Amnesia?

Transient Global Amnesia or TGA is a sudden, temporary episode of confusion and memory loss, where a person cannot form new memories (anterograde amnesia) and may have trouble recalling recent past events (retrograde amnesia).

Individuals with TGA often repeatedly ask the same questions because they forget the answers, but they retain their sense of self and recognize close friends and family. Episodes are usually benign, resolve within 24 hours, and do not result in lasting neurological damage.

While the cause of transient global amnesia is not known, experts believe that there could be a link between TGA and a history of migraines. However, the factors that contribute in the link of these two conditions are still not fully understood.

Common Signs Of Transient Global Amnesia

• Sudden onset of confusion and memory loss
• Inability to form new memories
• Repetitive questioning about their situation
• Disorientation regarding their location and recent events
• Retention of personal identity and recognition of familiar people
• Preserved ability to perform complex tasks, language, and other cognitive functions