“I'm not great at the advice. Can I interest you in a sarcastic comment?”

This is what ‘Friends’ actor Matthew Perry’s character Chandler Bing was known for. He was known for being funny. However, he had his own struggles in his personal life and those struggles were acute depression. He was treating it with ketamine infusion therapy which is legal in the US and the UK.

What is Ketamine infusion therapy?

Ketamine is an anaesthetic used to treat depression, anxiety and pain under supervised and controlled medical settings. However, it does have its side effects, which can lead to distortion of sight, sound and time. It can also produce calming and relaxing effects.

Ketamine increases a person’s heart rate and blood pressure. If overdosed, it can leave users confused and agitated and can cause them to hurt themselves without even realising it. It can also lead to liver damage and bladder problems.

However, when used in moderation and under the supervision of medical doctors, it can treat depression where traditional antidepressants have failed.

Prof Rupert McShane, a University of Oxford psychiatrist who runs an NHS ketamine treatment clinic told BBC that ketamine “probably turns off the area of the brain that is involved in disappointment.”

Can Ketamine Infusion Therapy Kill Someone?

In simple terms, it cannot, be if the dosage is given in a controlled setting and as prescribed. Ketamine infusion therapy uses drugs in small doses than those used for anaesthesia. It acts faster than traditional anti-depressants, but the effects also wear off way quickly. Which is why it is important to monitor patients’ mental state for relapsing back into depression and discouraging them from overdosing on it.

There are ways of giving people ketamine. One of the ways is through “infusing”, which means to use an IV drip. However, injections, nasal sprays and capsules are also methods used to give people ketamine.

Since the dosage of ketamine used in the infusion treatment is small, it being the reason of actor Perry’s death was ruled out. The medical examiner also noted that Perry’s last ketamine infusion therapy session happened more than a week before his death, which means by the time he had died, it must have worn off.

So, What Happened To Perry?

Though Perry’s last session was more than a week before, his post-mortem showed that his blood contained a high concentration of ketamine. He had died of the “acute effects” of ketamine.

If it was not his session, then how did he get ketamine?

Prosecutors alleged that his assistant gave him at least 27 shots of ketamine in four days before his death, reported BBC.

Perry has been open about his personal struggles and this is what the doctors and dealers used against him. Martin Estrada, the US attorney for California’s Central District told the BBC that people took advantage of his condition. They charged him 165 times more than what vials of ketamine cost.

Names that have come up include Dr Salvador Plasencia, drug dealers “Ketamine Queen” aka Jasveen Sangha and Eric Fleming, and Perry’s live-in assistant Kenneth Iwamasa.

Who Are These Names And What Did They Do?

Ketamine Queen or Sangha supplied drugs that led to Perry’s death. Her home was a “drug-selling emporium,” said Estrada. More than 80 vials of ketamine, and thousands of pills including methamphetamine, cocaine and Xanax were allegedly found in her house known as the “Sangha Stash House.”

Sangha is known to deal with high-end celebs and was a “major source of supply for ketamine to others as well as Perry,” said Estrada.

Dr Plasencia called Perry a “moron” while charging him $2,000 for vials that cost only $12. He sold Perry 20 vials of ketamine between September and October 2023, costing $55,000.

He was the one who taught Iwamasa, who had no medical knowledge to inject the drug. This is after he knew that “Perry’s ketamine addiction was spiralling out of control,” as per what the investigators told the BBC.

Another dealer Fleming was told by Sangha to “delete all our messages.” While Fleming pleaded guilty to conspiring to distribute drugs unlawfully, he also allegedly messaged Sangha: “Please call...Got more info and want to bounce ideas off you. I’m 90% sure everyone is protected. I never dealt with [Perry] only his assistant. So the assistant was the enabler.”

The court documents also revealed that he asked Sangha on whether the ketamine stays in your system or “is it immediately flushed out.”

Dr Pepper, Bots, Cans

The people who allegedly exploited Perry used coded language for ketamine and called it “Dr Pepper”, “bots”, or “cans.”

Selling overpriced drugs, taking advantage of Perry’s mental condition and falsifying medical records to make the drugs given to him look legitimate by Dr Plasencia is what took Perry’s life.

Iwamasa is said to have administered more than 20 shots of ketamine and three on the day Perry died. Whereas ketamine is only administered by a physician. Authorities also found that weeks before Perry’s death, Dr Plasencia allegedly bought 10 vials of ketamine and intended to sell to Perry.

He also injected Perry with a large dose, two days later. This caused him to “freeze up” and spiked his blood pressure.

When I Die, I Want Helping Others To Be The First Thing That’s Mentioned

Perry had always been open about his drug addictions, struggles with alcohol and his depression. He said that his openness would help others who are also struggling and wanted to be remembered by his quote which also is on the homepage of the Mattew Perry Foundation that helps others struggling with the disease of addiction: “When I die, I want helping others to be the first thing that’s mentioned.”

Five arrests have been made in the case so far.

Those taking omeprazole have been warned that certain other substances entering their system could undermine the effectiveness of the medication. Widely prescribed across the UK, this proton pump inhibitor (PPI) helps treat conditions such as heartburn, stomach ulcers, and gastro-oesophageal reflux disease (GERD). It works by lowering stomach acid levels and is available in multiple forms, including capsules, tablets, and liquids. Health guidance usually recommends that over-the-counter use should not exceed two weeks due to the risk of side effects.

However, depending on the severity of a person’s condition, a GP may advise continuing omeprazole for a longer period through prescription. NHS guidance highlights that if someone is taking multiple medications, certain drugs may interfere with omeprazole’s action.

What Is Omeprazole?

Omeprazole, sold under brand names such as Prilosec and Losec, is a commonly used medication that lowers the amount of acid the stomach produces. It belongs to a class of drugs called proton pump inhibitors (PPIs) and is used to treat conditions caused by excessive stomach acid, including heartburn, gastroesophageal reflux disease (GERD), and stomach ulcers, as per NHS.

Other Medicines That May Affect Omeprazole

The NHS UK website states: "There are some medicines, remedies and supplements that may not mix well with omeprazole."

Drug interactions can influence how well omeprazole works. Conversely, omeprazole itself may cause other medications to lose their effectiveness or behave differently than intended.

Medicines You Should Not Mix With Omeprazole

The NHS warns that people on omeprazole should be cautious with certain drugs, including:

• Lansoprazole
• Famotidine
• Diazepam
• Warfarin
• Clopidogrel
• Digoxin
• Phenytoin
• St John’s Wort
• Atazanavir
• Nelfinavir

Consult Your Doctor or Pharmacist

This list does not cover every medicine that may interact with omeprazole. If you are taking omeprazole, the NHS recommends checking with your doctor or pharmacist before taking any other medications, vitamins, supplements, or herbal remedies.

The leaflet included with your omeprazole pack provides further details about possible interactions. If you are unsure about the safety of combining omeprazole with other substances, it is best to seek advice from a pharmacist or doctor.

Why Long-Term Use of PPIs Can Be Risky

Dr Punam Krishan from BBC Morning Live cautioned that while proton pump inhibitors (PPIs) are generally safe when used as directed, they are not meant for indefinite use. “These medications shouldn’t be taken unnecessarily or for extended periods without a doctor’s oversight,” she said.

Prolonged use may slightly increase the risk of low magnesium or vitamin B12 levels and can make gut infections, particularly Clostridioides difficile (C. diff), more likely.

C. diff is a bacterium normally present in the gut, but it can multiply excessively when the gut balance is disrupted, sometimes leading to persistent diarrhoea. “That’s a warning sign,” Dr Krishan noted. “If you experience diarrhoea or notice changes in your bowel habits, consult your doctor right away. Regular check-ups are essential for anyone taking PPIs long-term.”

Medical Products Laboratories, a Philadelphia company that manufactures medical supplies, has pulled more than 41,000 bottles of Walgreens-branded nasal spray from the market after concerns that some units may contain bacteria that could pose problems for people with fragile immune systems or existing breathing issues.

The product involved is Walgreens Saline Nasal Spray with xylitol, which the U.S. Food and Drug Administration (FDA) says may be contaminated. In total, 41,328 bottles were shipped across the country and could contain pseudomonas lactis, a bacterium that naturally occurs in places such as soil and water, as noted by the Centers for Disease Control and Prevention (CDC).

Walgreens Nasal Spray Recalled: What Bacteria Is Found?

Pseudomonas lactis can cause illness in people with suppressed immunity or respiratory troubles, according to local officials in southeastern Massachusetts who reported the recall, along with television station KARE 11. WTVT also noted that the bacteria may pose added concerns for pregnant people. A 2022 study on antibiotic resistance found the same bacterium in chicken waste.

Which Walgreens Nasal Spray Lots Are Recalled?

The recall affects more than 41,000 bottles of Walgreens saline nasal spray with xylitol because of possible contamination with pseudomonas lactis, which may be risky for people who have compromised immune systems or lung conditions.

The lots included in the recall are Lot #71409, which expires on Feb. 28, 2027, and Lot #71861, which expires on Aug. 31, 2027. Walgreens told USA Today that anyone who bought these products should stop using them at once and bring them back to any Walgreens store for a complete refund.

What FDA Recall Classification Applies Here?

Based on the details available, this situation falls under a Class II recall, which the FDA uses when a product may lead to temporary or reversible health problems, and the chance of more serious harm is considered low. Similar recalls, such as the recent action involving NuNaturals sweeteners, have received the same level of risk designation from the agency.

A Class II recall signals that there is a meaningful health concern, though it is not expected to result in severe injury or death. This matches the structure of the D-0179-2026 classification and reflects how the FDA organizes consumer product recalls. A Walgreens spokesperson told FOX Business that the company’s supplier began the voluntary recall “out of an abundance of caution” and added that customer safety remains a priority.

What To Do With The Recalled Product?

Anyone who has one of the affected bottles should stop using it right away. Walgreens has not posted specific instructions on its website, but the general guidance is to discard the product or return it to the store where it was purchased.

Ozempic 2.0: The arrival of Ozempic and similar GLP-1 drugs has already reshaped medicine and consumer behaviour in ways few anticipated. Millions of people have achieved weight loss at levels previously unseen, grocery companies are redesigning products with these users in mind, and insurers are studying how these drugs could influence long-term health and chronic disease. But as significant as this shift has been, the next wave of treatments may transform the field even further, according to the Washington Post.

What Is Ozempic 2.0?

A new generation of GLP-1 therapies is expected in the coming months, including daily pills, more potent injectables, and combination drugs that target multiple hormonal pathways. These options promise easier use, wider metabolic benefits, and in some cases results beyond what current medications offer. Experts caution that these drugs are still under review by regulators, yet anticipation is already high.

Ozempic 2.0: Pills Could Make GLP-1 Medications Accessible

The first daily weight-loss pills may be approved as early as 2026. Novo Nordisk and Eli Lilly have developed oral versions of their popular drugs, providing an option for those who hesitate to self-inject or cannot afford refrigerated pens. Pills are also easier to distribute and could come with lower costs, potentially broadening access in regions where injectable GLP-1s remain expensive.

As per The Washington Post, early clinical trials show oral pills generally result in slightly less weight loss than injections. Participants typically shed around 11–14 percent of body weight over a year, compared with 15–20 percent for the most powerful injectables. Yet researchers believe that convenience, affordability, and broader insurance coverage could make daily pills a turning point for patients and the market alike.

Ozempic 2.0: Stronger Injectables May Make Weight Loss More Easy

Pharma companies are also working on injectables that stimulate multiple appetite-related hormones. Current GLP-1 drugs usually target one or two pathways, while Eli Lilly is testing a compound that acts on three. In mid-stage trials, participants on the highest dose lost more than 24 percent of their body weight in under a year—a result experts say comes close to the effectiveness of bariatric surgery.

As per The Washington Post, researchers note that outcomes may vary when larger and longer trials are completed. Regulators will need to assess safety carefully, especially regarding rapid weight loss or changes in muscle mass. Even so, specialists expect that patients with severe obesity may rely on these stronger options when they become available.

Ozempic 2.0: Molecules To Reduce Side Effects

Nausea, digestive discomfort, and lean muscle loss remain common reasons patients stop current GLP-1 drugs. In response, companies are testing combinations aimed at delivering similar weight loss with fewer side effects. One promising approach pairs semaglutide—the compound behind Ozempic and Wegovy—with amylin. Early data suggests this combination can achieve roughly 20 percent weight loss with potentially less digestive strain.

Other research focuses on adjusting hormonal signals to preserve muscle. Trials combining multiple appetite-regulating pathways show encouraging reductions in fat while maintaining more lean tissue, which experts view as vital for long-term metabolic health.

Ozempic 2.0: Monthly Injections Could Replace Weekly Doses

Beyond pills and more potent weekly injectables, some companies are developing drugs that require only a single injection each month. If successful, these treatments could remove one of the biggest barriers for patients struggling with weekly dosing schedules.

Even as new treatments emerge, today’s GLP-1 drugs are unlikely to vanish. Years of safety data, approvals for reducing cardiovascular risk, and expanded use for conditions like sleep apnea give existing medications an edge that newcomers must match. Competition and shifting pricing structures are already pushing costs down, potentially making current options more attractive unless new alternatives clearly outperform them.

Still, the change underway is unmistakable. With multiple drug classes, delivery methods, and hormonal targets in development, the next five years could redefine medical weight loss, and who has access to it.