“I'm not great at the advice. Can I interest you in a sarcastic comment?”

This is what ‘Friends’ actor Matthew Perry’s character Chandler Bing was known for. He was known for being funny. However, he had his own struggles in his personal life and those struggles were acute depression. He was treating it with ketamine infusion therapy which is legal in the US and the UK.

What is Ketamine infusion therapy?

Ketamine is an anaesthetic used to treat depression, anxiety and pain under supervised and controlled medical settings. However, it does have its side effects, which can lead to distortion of sight, sound and time. It can also produce calming and relaxing effects.

Ketamine increases a person’s heart rate and blood pressure. If overdosed, it can leave users confused and agitated and can cause them to hurt themselves without even realising it. It can also lead to liver damage and bladder problems.

However, when used in moderation and under the supervision of medical doctors, it can treat depression where traditional antidepressants have failed.

Prof Rupert McShane, a University of Oxford psychiatrist who runs an NHS ketamine treatment clinic told BBC that ketamine “probably turns off the area of the brain that is involved in disappointment.”

Can Ketamine Infusion Therapy Kill Someone?

In simple terms, it cannot, be if the dosage is given in a controlled setting and as prescribed. Ketamine infusion therapy uses drugs in small doses than those used for anaesthesia. It acts faster than traditional anti-depressants, but the effects also wear off way quickly. Which is why it is important to monitor patients’ mental state for relapsing back into depression and discouraging them from overdosing on it.

There are ways of giving people ketamine. One of the ways is through “infusing”, which means to use an IV drip. However, injections, nasal sprays and capsules are also methods used to give people ketamine.

Since the dosage of ketamine used in the infusion treatment is small, it being the reason of actor Perry’s death was ruled out. The medical examiner also noted that Perry’s last ketamine infusion therapy session happened more than a week before his death, which means by the time he had died, it must have worn off.

So, What Happened To Perry?

Though Perry’s last session was more than a week before, his post-mortem showed that his blood contained a high concentration of ketamine. He had died of the “acute effects” of ketamine.

If it was not his session, then how did he get ketamine?

Prosecutors alleged that his assistant gave him at least 27 shots of ketamine in four days before his death, reported BBC.

Perry has been open about his personal struggles and this is what the doctors and dealers used against him. Martin Estrada, the US attorney for California’s Central District told the BBC that people took advantage of his condition. They charged him 165 times more than what vials of ketamine cost.

Names that have come up include Dr Salvador Plasencia, drug dealers “Ketamine Queen” aka Jasveen Sangha and Eric Fleming, and Perry’s live-in assistant Kenneth Iwamasa.

Who Are These Names And What Did They Do?

Ketamine Queen or Sangha supplied drugs that led to Perry’s death. Her home was a “drug-selling emporium,” said Estrada. More than 80 vials of ketamine, and thousands of pills including methamphetamine, cocaine and Xanax were allegedly found in her house known as the “Sangha Stash House.”

Sangha is known to deal with high-end celebs and was a “major source of supply for ketamine to others as well as Perry,” said Estrada.

Dr Plasencia called Perry a “moron” while charging him $2,000 for vials that cost only $12. He sold Perry 20 vials of ketamine between September and October 2023, costing $55,000.

He was the one who taught Iwamasa, who had no medical knowledge to inject the drug. This is after he knew that “Perry’s ketamine addiction was spiralling out of control,” as per what the investigators told the BBC.

Another dealer Fleming was told by Sangha to “delete all our messages.” While Fleming pleaded guilty to conspiring to distribute drugs unlawfully, he also allegedly messaged Sangha: “Please call...Got more info and want to bounce ideas off you. I’m 90% sure everyone is protected. I never dealt with [Perry] only his assistant. So the assistant was the enabler.”

The court documents also revealed that he asked Sangha on whether the ketamine stays in your system or “is it immediately flushed out.”

Dr Pepper, Bots, Cans

The people who allegedly exploited Perry used coded language for ketamine and called it “Dr Pepper”, “bots”, or “cans.”

Selling overpriced drugs, taking advantage of Perry’s mental condition and falsifying medical records to make the drugs given to him look legitimate by Dr Plasencia is what took Perry’s life.

Iwamasa is said to have administered more than 20 shots of ketamine and three on the day Perry died. Whereas ketamine is only administered by a physician. Authorities also found that weeks before Perry’s death, Dr Plasencia allegedly bought 10 vials of ketamine and intended to sell to Perry.

He also injected Perry with a large dose, two days later. This caused him to “freeze up” and spiked his blood pressure.

When I Die, I Want Helping Others To Be The First Thing That’s Mentioned

Perry had always been open about his drug addictions, struggles with alcohol and his depression. He said that his openness would help others who are also struggling and wanted to be remembered by his quote which also is on the homepage of the Mattew Perry Foundation that helps others struggling with the disease of addiction: “When I die, I want helping others to be the first thing that’s mentioned.”

Five arrests have been made in the case so far.

Melanie Sykes has shared an encouraging health update, revealing that she is experiencing what she describes as “Post-Traumatic Growth.” On Friday, the former television presenter, 55, spoke openly on Instagram about feeling “vibrating high” after what she called moving through deep trauma. Her comments come amid an ongoing struggle with an autoimmune condition that has caused widespread inflammation and left her almost two-thirds bald.

Melanie Sykes Reveals She’s Living With ‘Post-Traumatic Growth’

In her message, Sykes reflected on how difficult periods do not last forever and introduced the idea of post-traumatic growth to her followers. She explained that it is possible to live with PTSD while also experiencing growth at the same time. “I’m in both camps,” she said, adding that people can hold pain and progress together, as long as they take care of themselves, allow space for grief, process what has happened, and then move forward in ways that bring happiness and meaning.

What Is ‘Post-Traumatic Growth’

Post-Traumatic Growth, often referred to as PTG, describes the positive psychological change that can emerge after someone has faced severe stress or trauma. Rather than simply managing or surviving the experience, people may find new depth in how they see life, feel stronger connections with others, discover fresh possibilities, or undergo spiritual or existential shifts. According to the National Institute of Health, PTG is not about bouncing back to how life was before. Instead, it reflects a deeper transformation that can take a person beyond their pre-trauma sense of self.

How Is Post Traumatic Growth Different From PTSD?

Post-Traumatic Stress Disorder, or PTSD, is marked by ongoing distress following trauma, including intrusive thoughts, avoidance, heightened alertness, and emotional suffering. PTG, on the other hand, refers to the positive psychological changes that can arise after working through trauma, such as greater appreciation for life, stronger relationships, personal strength, and shifts in belief or purpose. As noted by the National Institute of Health, the key difference lies in the outcome. PTSD is considered a mental health disorder, while PTG is a process of meaning-making and growth. Importantly, the two can exist together, with some individuals experiencing distress and growth at the same time.

At its core, PTSD reflects the painful impact of trauma, while post-traumatic growth represents the possibility of positive change that can develop through the long and often difficult path of healing, sometimes alongside or after living with PTSD.

What Condition Is Melanie Sykes Going Through?

Melanie lives with an autoimmune condition, a disorder in which the body’s immune system, meant to protect against infections, wrongly targets its own healthy cells, tissues, and organs. This immune response leads to inflammation and ongoing damage. Common autoimmune diseases include lupus, rheumatoid arthritis, and type 1 diabetes. Although there is no cure, treatment usually focuses on controlling symptoms such as fatigue, pain, and swelling and helping people manage the condition in daily life.

Just hours after GRAP-3 restrictions were implemented, authorities tightened pollution controls in Delhi and surrounding areas on Saturday evening by moving to GRAP-4.

Earlier in the afternoon, the Commission for Air Quality Management (CAQM)—the central agency responsible for monitoring and managing pollution in Delhi and neighbouring states—had imposed GRAP-3 curbs as the Air Quality Index (AQI) surpassed 400, entering the ‘Severe’ category.

By evening, the CAQM reported that the AQI, which was 431 at 4 pm, continued to rise and reached 441 by 6 pm. Under the GRAP system, air quality is divided into four levels: Poor (AQI 201–300), Very Poor (AQI 301–400), Severe (AQI 401–450), and Severe Plus (AQI above 450).

The CAQM stated, “Considering the current air quality trend and to prevent further deterioration in the region, the Sub-Committee on GRAP has decided to implement all measures under Stage IV of the existing GRAP – ‘Severe+’ Air Quality (Delhi AQI > 450) – with immediate effect across the entire NCR. These measures are in addition to the actions already in place under Stages I, II, and III.”

The commission added that the primary reason for the worsening AQI was the weak Western Disturbance moving toward north-west India, rather than local emissions.

GRAP 4 In Delhi: Schools Shift to Hybrid Classes

While schools in Delhi remain open, classes for several grades have moved to a hybrid format, combining both in-person and online learning. The Delhi Directorate of Education (DDE) issued a circular directing all government, aided, and private schools under DOE, NDMC, MCD, and Delhi Cantonment Board to adopt hybrid classes for students up to Class IX and XI wherever online teaching is feasible.

The circular, dated December 13, states: “All Heads of Schools…are directed to conduct classes in schools for children up to Class IX and XI in a ‘Hybrid Mode’ i.e., both physical and online mode (wherever online mode is feasible) with immediate effect until further orders.”

GRAP 4 In Delhi: Are Delhi Schools Open Today?

Yes, all schools under the Delhi Directorate of Education remain open. Students up to Class IX and Class XI can attend classes either physically or online, depending on what they or their parents choose. The hybrid arrangement will continue until further notice. The directive also applies to schools managed by NDMC, MCD, and Delhi Cantonment Board. School authorities have been asked to promptly inform parents and guardians about the arrangements.

GRAP 4 Activated as Pollution Worsens

The move comes after the Commission for Air Quality Management (CAQM) declared Stage 4 of GRAP with immediate effect, as Delhi’s Air Quality Index (AQI) surged into the ‘severe’ category. At 6 am on Sunday, the AQI in the city stood at 462, according to the Central Pollution Control Board’s Sameer app.

GRAP 4 In Delhi: Restrictions Under Stage 4

Stage 4 maintains all measures from Stage 3 and introduces stricter curbs to limit pollution. Among the new restrictions is a total ban on truck traffic entering Delhi, except for vehicles carrying essential goods or providing critical services. Trucks powered by LNG, CNG, electricity, and BS-VI diesel are exempt from the ban.

At-risk groups are being encouraged to get their flu jabs as concern grows over rising flu cases across the UK. The NHS has warned of a possible “tidal wave” of infections after flu activity began earlier than usual this season, with some schools already forced to shut because of outbreaks.

A post shared this week by the UK Health Security Agency (UKHSA) on X urged people to take vaccination seriously. It said: “Help protect yourself with a flu vaccine, it’s just like protective armour for those with long-term health conditions like #kidney disease. Stay strong. Get vaccinated.”

What Is The H3N2 Flu Strain?

Health officials have described the newly emerging H3N2 flu strain as particularly “unpleasant” and warned that the NHS may be heading toward a heavy surge in cases in the run-up to Christmas.

Flu-related hospital admissions have already risen by 56 per cent compared with the same period last year, and specialists say the worst of the season may still lie ahead. In response, health leaders have advised people to wear a face covering in public if they are feeling unwell and have urged everyone who qualifies for a flu jab to get vaccinated as soon as possible.

How Can Flu Vaccine Protect From the Flu?

Flu vaccines are meant to protect against influenza, which can be dangerous and even fatal for some groups. Every autumn or early winter, the NHS rolls out the flu jab programme for people who are more likely to develop serious complications from the virus.

Eligibility For Flu Vaccine In UK

According to official UKHSA guidance, six main groups became eligible for the flu vaccine from September 1 this year, while another six groups were added from October 1.

From September 1, this included:

• Pregnant women
• All children aged two or three years old on August 31, 2025
• Children with certain long-term health conditions (aged six months to under 18 years)
• Primary school-aged children (from reception to Year 6)
• Secondary school-aged children (from Year 7 to Year 11)
• All children in clinical risk groups aged from six months to under 18 years

And from October 1, 2025, this included:

• Everyone aged 65 years old and over
• Anyone aged 18 to 65 with long-term health conditions

Health and social care workers may also be offered the flu jab through their workplace. The NHS says it is generally safe to have the flu vaccine at the same time as other jabs, including COVID-19 and shingles vaccines.

The RSV vaccine is usually given separately, but NHS guidance notes that a doctor may decide to give both vaccines together in certain situations.

Super Flu Cases In UK

Amid the recent rise in flu cases, a Downing Street spokesperson also reiterated guidance this week, saying: “There is long-standing guidance in place for people on a range of measures they can consider taking to help limit the spread of winter bugs if they have flu-like symptoms.

“This is neither new nor an instruction but simply something people can consider when trying to limit the spread of winter respiratory illnesses.”

Citing a previous Mirror report, they added: “It’s been a long-standing position. The best defence against flu is the vaccine, which is why we’re ramping up our vaccination efforts this winter with almost 17 million flu jabs already delivered, which is 350,000 more than this time last year.”

The NHS App can be used to check whether you are eligible for a flu jab. Vaccinations are available through GP surgeries, selected pharmacies, maternity clinics, and care homes.