“I'm not great at the advice. Can I interest you in a sarcastic comment?”

This is what ‘Friends’ actor Matthew Perry’s character Chandler Bing was known for. He was known for being funny. However, he had his own struggles in his personal life and those struggles were acute depression. He was treating it with ketamine infusion therapy which is legal in the US and the UK.

What is Ketamine infusion therapy?

Ketamine is an anaesthetic used to treat depression, anxiety and pain under supervised and controlled medical settings. However, it does have its side effects, which can lead to distortion of sight, sound and time. It can also produce calming and relaxing effects.

Ketamine increases a person’s heart rate and blood pressure. If overdosed, it can leave users confused and agitated and can cause them to hurt themselves without even realising it. It can also lead to liver damage and bladder problems.

However, when used in moderation and under the supervision of medical doctors, it can treat depression where traditional antidepressants have failed.

Prof Rupert McShane, a University of Oxford psychiatrist who runs an NHS ketamine treatment clinic told BBC that ketamine “probably turns off the area of the brain that is involved in disappointment.”

Can Ketamine Infusion Therapy Kill Someone?

In simple terms, it cannot, be if the dosage is given in a controlled setting and as prescribed. Ketamine infusion therapy uses drugs in small doses than those used for anaesthesia. It acts faster than traditional anti-depressants, but the effects also wear off way quickly. Which is why it is important to monitor patients’ mental state for relapsing back into depression and discouraging them from overdosing on it.

There are ways of giving people ketamine. One of the ways is through “infusing”, which means to use an IV drip. However, injections, nasal sprays and capsules are also methods used to give people ketamine.

Since the dosage of ketamine used in the infusion treatment is small, it being the reason of actor Perry’s death was ruled out. The medical examiner also noted that Perry’s last ketamine infusion therapy session happened more than a week before his death, which means by the time he had died, it must have worn off.

So, What Happened To Perry?

Though Perry’s last session was more than a week before, his post-mortem showed that his blood contained a high concentration of ketamine. He had died of the “acute effects” of ketamine.

If it was not his session, then how did he get ketamine?

Prosecutors alleged that his assistant gave him at least 27 shots of ketamine in four days before his death, reported BBC.

Perry has been open about his personal struggles and this is what the doctors and dealers used against him. Martin Estrada, the US attorney for California’s Central District told the BBC that people took advantage of his condition. They charged him 165 times more than what vials of ketamine cost.

Names that have come up include Dr Salvador Plasencia, drug dealers “Ketamine Queen” aka Jasveen Sangha and Eric Fleming, and Perry’s live-in assistant Kenneth Iwamasa.

Who Are These Names And What Did They Do?

Ketamine Queen or Sangha supplied drugs that led to Perry’s death. Her home was a “drug-selling emporium,” said Estrada. More than 80 vials of ketamine, and thousands of pills including methamphetamine, cocaine and Xanax were allegedly found in her house known as the “Sangha Stash House.”

Sangha is known to deal with high-end celebs and was a “major source of supply for ketamine to others as well as Perry,” said Estrada.

Dr Plasencia called Perry a “moron” while charging him $2,000 for vials that cost only $12. He sold Perry 20 vials of ketamine between September and October 2023, costing $55,000.

He was the one who taught Iwamasa, who had no medical knowledge to inject the drug. This is after he knew that “Perry’s ketamine addiction was spiralling out of control,” as per what the investigators told the BBC.

Another dealer Fleming was told by Sangha to “delete all our messages.” While Fleming pleaded guilty to conspiring to distribute drugs unlawfully, he also allegedly messaged Sangha: “Please call...Got more info and want to bounce ideas off you. I’m 90% sure everyone is protected. I never dealt with [Perry] only his assistant. So the assistant was the enabler.”

The court documents also revealed that he asked Sangha on whether the ketamine stays in your system or “is it immediately flushed out.”

Dr Pepper, Bots, Cans

The people who allegedly exploited Perry used coded language for ketamine and called it “Dr Pepper”, “bots”, or “cans.”

Selling overpriced drugs, taking advantage of Perry’s mental condition and falsifying medical records to make the drugs given to him look legitimate by Dr Plasencia is what took Perry’s life.

Iwamasa is said to have administered more than 20 shots of ketamine and three on the day Perry died. Whereas ketamine is only administered by a physician. Authorities also found that weeks before Perry’s death, Dr Plasencia allegedly bought 10 vials of ketamine and intended to sell to Perry.

He also injected Perry with a large dose, two days later. This caused him to “freeze up” and spiked his blood pressure.

When I Die, I Want Helping Others To Be The First Thing That’s Mentioned

Perry had always been open about his drug addictions, struggles with alcohol and his depression. He said that his openness would help others who are also struggling and wanted to be remembered by his quote which also is on the homepage of the Mattew Perry Foundation that helps others struggling with the disease of addiction: “When I die, I want helping others to be the first thing that’s mentioned.”

Five arrests have been made in the case so far.

Avian or bird flu (H5N1) is a viral infection that spreads in birds, cows and other animals and can cause severe illness and at times, be fatal to humans in rare cases. Until now, the flu primarily affected wild aquatic birds including ducks, geese, gulls and poultry such as chickens as well as turkeys.

However earlier this month, a dairy cow in the Netherlands appears to have been contracted bird flu, making this the first time cattle outside of the United States has suffered the infection.

Previously, transmission of avian flu from cattle to humans has only been reported in the US among farm workers exposed to infected cattle or contaminated environments, and such cases remain sporadic and all developed only mild symptoms.

How Was The Cow Infected?

According to a detailed letter from the Dutch agriculture minister, a cat on a dairy farm in the province of Friesland died from H5N1 last month, which prompted officials to sample blood and milk from cattle at the farm.

Out of the 20 tested, one cow had antibodies to the virus in its milk but did not test positive for the virus itself. “There are also no signs of avian influenza spreading to other dairy farms,” the minister wrote.

The cow had mastitis and respiratory problems last month and its milk was not processed, the letter stated. Also, milk from the farm had been pasteurized, which inactivates the virus and prevents it being transmitted to humans.

“This means that there is very little chance that virus from the infected cow has ended up in the milk for human consumption,” the minister assured. It remains unclear how the virus arrived at the farm or how the cat and cow became infected.

Since October 2025, more than three dozen farms in the Netherlands have had outbreaks and over 1.5 million chickens, turkeys and ducks have been killed to stop the virus’ spread.

Is Bird Flu Dangerous For Humans?

The H5N1 strain drew worldwide concern in the early 2000s because of its high fatality rate in infected people. Although sustained human-to-human transmission is uncommon, infection can occur through close contact with sick or dead birds, their droppings, or contaminated environments.

Bird flu has posed major challenges for both the poultry industry and public health systems, with outbreaks often resulting in large-scale culling to limit the spread.

India has experienced recurring avian influenza outbreaks, particularly in regions with dense poultry farming. Even with strict control measures in birds, the risk of human infection persists, making awareness, hygiene practices, and preventive steps essential for protecting public health.

The common ways humans can contract the virus include:

• Direct contact with infected birds: Handling sick or dead birds, cleaning poultry farms, or working in live bird markets increases the risk
• Exposure to contaminated surfaces: The virus can survive on surfaces such as bird cages, equipment, and clothing. Touching these and then touching the eyes, nose, or mouth can lead to infection
• Consumption of undercooked poultry or eggs: While properly cooked poultry is safe, raw or undercooked meat and eggs from infected birds may pose a risk
• Airborne transmission in poultry farms: In rare cases, workers in enclosed spaces with infected birds may inhale tiny virus-laden particles

In a breakthrough study, a group of Spanish researchers have created a drug-based cure that can kill pancreatic cancer tumors in the body and eliminate the disease completely.

A study from the Spanish National Cancer Research Centre (CNIO) found that a combination of three drugs, known as CNIO therapy, can shut down multiple tumor survival mechanisms at the same time, preventing the cells from the rewiring themselves and defeating the treatment

Led by renowned cancer biologist Dr Mariano Barbacid, the authors wrote of the results: 'These studies open a way to design new combination therapies that can improve the survival of patients with pancreatic ductal adenocarcinoma. These results set the direction for the development of new clinical trials."

How Does The Drug Work?

To overcome cancer's ability to block the effects of singular therapy drugs, Dr Barbacid’s team attempted attacking the cancerous tumors from three directions together.

The first drug, daraxonrasib, blocked the main KRAS signal that drives tumor growth while the second drug, afatinib, shut down EGFR and HER2, both pathways that cancer cells often use to escape KRAS-targeted treatment.

The third drug, SD36, stopped the functioning of bSTAT3, a backup system that helps cancer cells survive stress and resist therapy.

In the mice study, when scientists combined and used all three drugs together in the rodents, they saw the pancreatic tumours shrank completely and did not return, even more than 200 days after treatment stopped.

The same effect was seen in genetically engineered mouse models and in tumors taken from human patients that were grown in a laboratory. The animals who underwent CNIO therapy did not show serious side effects, suggesting the combination could be safe enough to test in humans.

Despite promising results, the authors advised caution and noted: ""We are not yet in a position to carry out clinical trials with triple therapy. The authors themselves warn that optimising this combination for patients will be a complex process, although they are confident that the finding will set the course for future trials."

Pancreatic Cancer: All You Need To Know

While there are no clear signs of early pancreatic cancer, symptoms begin to show once the disease reaches the digestive system. Some of these include:

• Jaundice (yellowing of your skin).
• Dark urine
• Light-colored stool
• Upper abdominal pain
• Middle back pain
• Fatigue
• Itchy skin
• Nausea and vomiting
• Gas or bloating
• Lack of appetite
• Blood clots
• Weight loss
• New-onset diabetes

Certain prominent risk factors include smoking cigarettes, cigars and using other forms of tobacco; obesity; Type 2 diabetes and genetic factors.

Pancreatic cancer is also resistant to many common cancer drugs and it notoriously difficult to treat, making this discovery exceptionally important in the search for a permanent cure.

About 22,000 new cases of pancreatic cancer are estimated to occur annually in India out of which nearly 13,000 die from the cause, making it the 24th most common cancer in India.

A collective of environmental and public health researchers has raised serious concerns over free-living amoebas, warning that these organisms could become an increasing global health risk. Their concern stems from the amoebas’ ability to survive in harsh conditions and bypass routine water treatment processes.

These tiny protozoa occur naturally in soil and freshwater and are usually harmless. However, certain species, particularly Naegleria fowleri, widely referred to as the “brain-eating amoeba,” can trigger rare but deadly infections when contaminated water enters the nose during activities such as swimming or diving.

This issue is especially significant for India, as Naegleria fowleri causes primary amoebic meningoencephalitis (PAM), a fatal condition that has seen repeated outbreaks in states such as Kerala.

What Is Naegleria Fowleri?

Naegleria fowleri is a free-living ameba, meaning it is a single-celled organism that survives independently in the environment. It flourishes in warm freshwater sources such as lakes, rivers, ponds, and hot springs. Commonly labelled the “brain-eating ameba,” it earns this name because of its ability to infect the brain and damage brain tissue. The organism is found worldwide in soil and warm freshwater bodies.

On rare occasions, it has also been detected in inadequately maintained swimming pools, splash pads, and other recreational water facilities. In some instances, the ameba has even been identified in tap water.

According to the US Centers for Disease Control and Prevention (CDC), when water containing the ameba enters the nose and reaches the brain, it can lead to an infection known as primary amebic meningoencephalitis (PAM). In the United States, PAM affects fewer than 10 people each year. Almost everyone diagnosed with PAM does not survive. From 1962 to 2024, 167 cases were reported in the US, with only four known survivors.

What Is Primary Amebic Meningoencephalitis?

Primary Amebic Meningoencephalitis (PAM) is a rare but almost always fatal brain infection caused by the Naegleria fowleri amoeba, often called the “brain-eating amoeba.” The organism enters the body through the nose from warm freshwater or soil, travels to the brain, and destroys brain tissue. This leads to intense inflammation, confusion, seizures, and, in most cases, death within days of the onset of severe symptoms.

Primary Amebic Meningoencephalitis Signs And Symptoms

Early signs of PAM may include headache, fever, nausea, and vomiting. The disease progresses very quickly. Most patients die within one to 18 days after symptoms appear, with coma and death often occurring within five days. As the infection advances, symptoms can worsen to include a stiff neck, confusion, reduced awareness of people and surroundings, loss of balance, and hallucinations.

Brain Eating Amoeba Can Thrive In Heat

In a recent perspective published in the journal Biocontaminant, scientists led by Longfei Shu from Sun Yat-sen University explain how climate change, ageing infrastructure, and poor monitoring systems are creating conditions that allow these microbes to spread into areas where they were previously uncommon. Some species are capable of surviving high temperatures and can withstand disinfectants such as chlorine, making them particularly difficult to remove from drinking water supplies and distribution systems.

Adding to the concern, free-living amoebas can serve as protective carriers for harmful bacteria and viruses, housing them inside their cells and helping them spread. This so-called “Trojan horse” effect has raised fresh questions about water safety and how pathogens move through the environment, highlighting the need for coordinated, One Health-based approaches.

Experts warn that without strong intervention and improved water management policies, free-living amoebas could emerge as a major and largely overlooked threat to global public health in the coming years.