“I'm not great at the advice. Can I interest you in a sarcastic comment?”

This is what ‘Friends’ actor Matthew Perry’s character Chandler Bing was known for. He was known for being funny. However, he had his own struggles in his personal life and those struggles were acute depression. He was treating it with ketamine infusion therapy which is legal in the US and the UK.

What is Ketamine infusion therapy?

Ketamine is an anaesthetic used to treat depression, anxiety and pain under supervised and controlled medical settings. However, it does have its side effects, which can lead to distortion of sight, sound and time. It can also produce calming and relaxing effects.

Ketamine increases a person’s heart rate and blood pressure. If overdosed, it can leave users confused and agitated and can cause them to hurt themselves without even realising it. It can also lead to liver damage and bladder problems.

However, when used in moderation and under the supervision of medical doctors, it can treat depression where traditional antidepressants have failed.

Prof Rupert McShane, a University of Oxford psychiatrist who runs an NHS ketamine treatment clinic told BBC that ketamine “probably turns off the area of the brain that is involved in disappointment.”

Can Ketamine Infusion Therapy Kill Someone?

In simple terms, it cannot, be if the dosage is given in a controlled setting and as prescribed. Ketamine infusion therapy uses drugs in small doses than those used for anaesthesia. It acts faster than traditional anti-depressants, but the effects also wear off way quickly. Which is why it is important to monitor patients’ mental state for relapsing back into depression and discouraging them from overdosing on it.

There are ways of giving people ketamine. One of the ways is through “infusing”, which means to use an IV drip. However, injections, nasal sprays and capsules are also methods used to give people ketamine.

Since the dosage of ketamine used in the infusion treatment is small, it being the reason of actor Perry’s death was ruled out. The medical examiner also noted that Perry’s last ketamine infusion therapy session happened more than a week before his death, which means by the time he had died, it must have worn off.

So, What Happened To Perry?

Though Perry’s last session was more than a week before, his post-mortem showed that his blood contained a high concentration of ketamine. He had died of the “acute effects” of ketamine.

If it was not his session, then how did he get ketamine?

Prosecutors alleged that his assistant gave him at least 27 shots of ketamine in four days before his death, reported BBC.

Perry has been open about his personal struggles and this is what the doctors and dealers used against him. Martin Estrada, the US attorney for California’s Central District told the BBC that people took advantage of his condition. They charged him 165 times more than what vials of ketamine cost.

Names that have come up include Dr Salvador Plasencia, drug dealers “Ketamine Queen” aka Jasveen Sangha and Eric Fleming, and Perry’s live-in assistant Kenneth Iwamasa.

Who Are These Names And What Did They Do?

Ketamine Queen or Sangha supplied drugs that led to Perry’s death. Her home was a “drug-selling emporium,” said Estrada. More than 80 vials of ketamine, and thousands of pills including methamphetamine, cocaine and Xanax were allegedly found in her house known as the “Sangha Stash House.”

Sangha is known to deal with high-end celebs and was a “major source of supply for ketamine to others as well as Perry,” said Estrada.

Dr Plasencia called Perry a “moron” while charging him $2,000 for vials that cost only $12. He sold Perry 20 vials of ketamine between September and October 2023, costing $55,000.

He was the one who taught Iwamasa, who had no medical knowledge to inject the drug. This is after he knew that “Perry’s ketamine addiction was spiralling out of control,” as per what the investigators told the BBC.

Another dealer Fleming was told by Sangha to “delete all our messages.” While Fleming pleaded guilty to conspiring to distribute drugs unlawfully, he also allegedly messaged Sangha: “Please call...Got more info and want to bounce ideas off you. I’m 90% sure everyone is protected. I never dealt with [Perry] only his assistant. So the assistant was the enabler.”

The court documents also revealed that he asked Sangha on whether the ketamine stays in your system or “is it immediately flushed out.”

Dr Pepper, Bots, Cans

The people who allegedly exploited Perry used coded language for ketamine and called it “Dr Pepper”, “bots”, or “cans.”

Selling overpriced drugs, taking advantage of Perry’s mental condition and falsifying medical records to make the drugs given to him look legitimate by Dr Plasencia is what took Perry’s life.

Iwamasa is said to have administered more than 20 shots of ketamine and three on the day Perry died. Whereas ketamine is only administered by a physician. Authorities also found that weeks before Perry’s death, Dr Plasencia allegedly bought 10 vials of ketamine and intended to sell to Perry.

He also injected Perry with a large dose, two days later. This caused him to “freeze up” and spiked his blood pressure.

When I Die, I Want Helping Others To Be The First Thing That’s Mentioned

Perry had always been open about his drug addictions, struggles with alcohol and his depression. He said that his openness would help others who are also struggling and wanted to be remembered by his quote which also is on the homepage of the Mattew Perry Foundation that helps others struggling with the disease of addiction: “When I die, I want helping others to be the first thing that’s mentioned.”

Five arrests have been made in the case so far.

New photos circulating on social media of President Donald Trump’s discolored, swollen, and visibly bruised hands have reignited concerns about his health.

The latest viral images show the 79-year-old Republican president at an event honoring military moms just ahead of Mother’s Day. In the photos, Trump’s hands appeared to be lathered in mismatched concealer, seemingly covering bruises. His hands also looked swollen, with white patches visible and purplish coloring apparent on his left hand through the patch.

“Yikes! Both of Trump's hands are discolored today, and one of them appears bruised as well,” one social media user commented.

Another wrote, “New photo shows heavy bruising and makeup on both of Trump's hands.”

Donald Trump's Health: What Does The White House Say

The White House, however, downplayed the concerns, emphasizing Trump’s energy and good health. Trump is “the sharpest, most accessible, and energetic president in American history”, White House spokesperson Davis Ingle said, the Daily Beast reported.

“The president is a man of the people, and he meets more Americans and shakes their hands on a daily basis than any other president in history. President Trump’s commitment is unwavering, and he proves that every single day,” Ingle added.

"Hand discoloration can be caused by several underlying conditions, including bruising (bleeding under the skin), low oxygen or poor circulation, swelling (fluid buildup), and infection or inflammation," Dr. Amit Prakash Singh, Consultant in Internal Medicine at CK Birla Hospital, Delhi, told HealthandMe.

In the past, the White House attributed the bruising on Trump’s hands to his high-dose aspirin regimen—he reportedly takes 325 milligrams daily, four times the typical recommended dose.

As the oldest person to assume the US presidency, Trump’s visible signs, including hand bruising and apparent leg swelling, have fueled ongoing public interest in his health.

Concerns about his mental health have also been raised; experts have reported behaviors such as seeking “great adulation” and becoming “angry if reality does not meet his needs,” according to BMJ.

Speaking on Monday at the White House Small Business Summit, Trump said he had taken the Montreal Cognitive Assessment three times and “aced each one,” claiming a doctor told him it was the first perfect score they had seen, according to The Daily Beast.

Trump also boasted about his ability to correctly identify a squirrel on the cognitive screening test. He suggested that answering the test questions easily demonstrated his cognitive fitness—a claim repeatedly questioned by critics.

Further, his recent visit to a dentist in Florida also sparked discussions about his health.

While past presidents have used the White House’s on-site clinic, Trump opted for a local dentist, as he had previously in January.

Last week, Trump was photographed with his son, Donald Trump Jr., with visible swelling in his ankles. Medical experts note this is likely linked to his chronic venous insufficiency (CVI), diagnosed last July. “CVI damages those valves, causing blood to pool in your legs. This increases pressure in your leg veins and causes symptoms like swelling and ulcers,” according to the Cleveland Clinic.

Trump’s Image Among Americans Takes A Hit

Read More: Donald Trump’s Weekend Dental Appointment Triggers Fresh Health Concerns

Nearly 60 percent of Americans are questioning whether Trump is healthy enough to serve in the Oval Office, according to a Washington Post–ABC News–Ipsos poll.

Alongside dissatisfaction with his leadership on the Iran war, the economy, and inflation, a growing share of Americans are also questioning his mental acuity.

Nearly 6 in 10 say he lacks the mental sharpness for the role, while 55 percent say he is not in good enough physical health to serve effectively.

Three suspected hantavirus patients have been evacuated from the ship and are on their way to receive medical care in the Netherlands, said Dr Tedros Adhanom Ghebreyesus, WHO Director-General, today.

The three patients evacuated from the MV Hondius cruise ship include

• a 56-year-old British national,
• a 65-year-old from Germany,
• a 41-year-old from the Netherlands.

The WHO chief noted that the global health agency “continues to work with the ship’s operators to closely monitor the health of passengers and crew, working with countries to support appropriate medical follow-up and evacuation where needed”.

“Monitoring and follow-up for passengers on board and for those who have already disembarked has been initiated in collaboration with the ship’s operators and national health authorities,” Dr Ghebreyesus said.

Hantavirus: 8 Suspected Cases, 3 Deaths

Also read: Hantavirus: Symptoms, Risks, and Prevention

Some passengers aboard the Hondius began experiencing serious health complications after the ship, carrying about 150 passengers, departed Argentina on April 1.

Initially, it was considered a severe acute respiratory infection; later, three people died.

• April 11: A 70-year-old Dutch national became the first passenger to die while on board the ship. His death has not yet been confirmed as due to hantavirus.
• April 24: The man’s 69-year-old wife travelled alongside her husband’s body from St Helena, a British island in the South Atlantic, to Johannesburg. Her condition deteriorated during a flight the next day, and she was taken to the hospital.
• April 26: The woman died in a hospital in South Africa. She is the first confirmed hantavirus case.
• April 27: A second sick passenger, a British national, was flown to South Africa and remains in a critical but stable condition in hospital with hantavirus.
• May 2: A German national died while on the ship; it is unclear if the passenger was infected.
• May 5: The Swiss government announced that a man who travelled home from his trip from South America on the MV Hondius cruise ship at the end of April visited the University Hospital Zurich after experiencing symptoms. He was immediately placed in isolation, with authorities saying there is no danger to the public. His wife, who accompanied him, has not shown symptoms but is also isolating as a precaution.
• May 6: WHO announces the evacuation of three infected passengers.

What Is Hantavirus?

Also read: Hantavirus Outbreak: How The Rare Rodent-Borne Virus Spreads

According to the WHO, hantaviruses are zoonotic viruses that naturally infect rodents and are occasionally transmitted to humans.

Symptoms include:

• Fever
• Headache
• Abdominal pain
• Diarrhea

Hantavirus: The Andes strain?

A team of scientists at South Africa’s National Institute for Communicable Diseases identified the strain of hantavirus linked to the cases.

In a presentation to parliament, the South African health minister said the Andes strain of hantavirus, which can spread human-to-human, had been identified in two people who disembarked from the cruise ship.

The Andes virus is the only hantavirus strain with documented human-to-human transmission and is more commonly found in South America.

Some people love tea, some can't get enough of coffee, but rarely does one think about if the same could influence disease risk later in life. According to a new study, women's risk of osteoporosis could be influenced by their choice of tea or coffee. Osteoporosis is a common occurrence in women aged 50 years and above. Statistics suggest that one in three women will likely be diagnosed with the disease, which renders the body incapable of replacing old bone after it undergoes wear and tear. This means bones become weak, brittle, and more prone to fractures. Bone problems at an advanced age in women can also slow down healing.

High-risk groups for osteoporosis

Older women are at a higher risk of osteoporosis, and that is because of oestrogen. Oestrogen supports bone metabolism, and its levels drop after menopause. Surgery can help remove a woman's ovaries, thereby resulting in the same effect. Researchers at Flinders University in Australia evaluated tea- and coffee-drinking habits of approximately 9,700 US women aged 65 years and above. Participants were required to self-report their tendencies in the survey on four occasions over a 10-year period.

The study also gathered data on women's bone health, measuring bone mineral density in the hip and the narrow connection to the hip with X-ray beams to deduce mineral levels in the bone. Researchers found that women who regularly drank tea had significantly higher hip BMD than those who did not. This could be because of tea compounds known as catechins that could provide the boost cells need to build strong bones. Even smaller differences can significantly improve bone health.

What are the benefits of tea for women's health?

Researchers noted that tea intake could be particularly beneficial for women dealing with obesity. Coffee habits, alternatively, had a different impact on BMD. Studies suggest that women who drank more than five cups of coffee a day were more likely to have lower BMD levels, thereby suggesting that caffeine can negatively affect calcium absorption in the body. Furthermore, experts noted that drinking any amount of coffee can reduce BMD levels in women, especially those who consumed high levels of alcohol.

Scientists note that, because of the limited scope of the study, more research is required in this area to ascertain the results. However, the study offers insights into the possible benefits of drinking tea for women living with osteoporosis. It can go a long way in improving overall wellness and long-term bone health in women.

The research is published in Nutrients.