“I'm not great at the advice. Can I interest you in a sarcastic comment?”

This is what ‘Friends’ actor Matthew Perry’s character Chandler Bing was known for. He was known for being funny. However, he had his own struggles in his personal life and those struggles were acute depression. He was treating it with ketamine infusion therapy which is legal in the US and the UK.

What is Ketamine infusion therapy?

Ketamine is an anaesthetic used to treat depression, anxiety and pain under supervised and controlled medical settings. However, it does have its side effects, which can lead to distortion of sight, sound and time. It can also produce calming and relaxing effects.

Ketamine increases a person’s heart rate and blood pressure. If overdosed, it can leave users confused and agitated and can cause them to hurt themselves without even realising it. It can also lead to liver damage and bladder problems.

However, when used in moderation and under the supervision of medical doctors, it can treat depression where traditional antidepressants have failed.

Prof Rupert McShane, a University of Oxford psychiatrist who runs an NHS ketamine treatment clinic told BBC that ketamine “probably turns off the area of the brain that is involved in disappointment.”

Can Ketamine Infusion Therapy Kill Someone?

In simple terms, it cannot, be if the dosage is given in a controlled setting and as prescribed. Ketamine infusion therapy uses drugs in small doses than those used for anaesthesia. It acts faster than traditional anti-depressants, but the effects also wear off way quickly. Which is why it is important to monitor patients’ mental state for relapsing back into depression and discouraging them from overdosing on it.

There are ways of giving people ketamine. One of the ways is through “infusing”, which means to use an IV drip. However, injections, nasal sprays and capsules are also methods used to give people ketamine.

Since the dosage of ketamine used in the infusion treatment is small, it being the reason of actor Perry’s death was ruled out. The medical examiner also noted that Perry’s last ketamine infusion therapy session happened more than a week before his death, which means by the time he had died, it must have worn off.

So, What Happened To Perry?

Though Perry’s last session was more than a week before, his post-mortem showed that his blood contained a high concentration of ketamine. He had died of the “acute effects” of ketamine.

If it was not his session, then how did he get ketamine?

Prosecutors alleged that his assistant gave him at least 27 shots of ketamine in four days before his death, reported BBC.

Perry has been open about his personal struggles and this is what the doctors and dealers used against him. Martin Estrada, the US attorney for California’s Central District told the BBC that people took advantage of his condition. They charged him 165 times more than what vials of ketamine cost.

Names that have come up include Dr Salvador Plasencia, drug dealers “Ketamine Queen” aka Jasveen Sangha and Eric Fleming, and Perry’s live-in assistant Kenneth Iwamasa.

Who Are These Names And What Did They Do?

Ketamine Queen or Sangha supplied drugs that led to Perry’s death. Her home was a “drug-selling emporium,” said Estrada. More than 80 vials of ketamine, and thousands of pills including methamphetamine, cocaine and Xanax were allegedly found in her house known as the “Sangha Stash House.”

Sangha is known to deal with high-end celebs and was a “major source of supply for ketamine to others as well as Perry,” said Estrada.

Dr Plasencia called Perry a “moron” while charging him $2,000 for vials that cost only $12. He sold Perry 20 vials of ketamine between September and October 2023, costing $55,000.

He was the one who taught Iwamasa, who had no medical knowledge to inject the drug. This is after he knew that “Perry’s ketamine addiction was spiralling out of control,” as per what the investigators told the BBC.

Another dealer Fleming was told by Sangha to “delete all our messages.” While Fleming pleaded guilty to conspiring to distribute drugs unlawfully, he also allegedly messaged Sangha: “Please call...Got more info and want to bounce ideas off you. I’m 90% sure everyone is protected. I never dealt with [Perry] only his assistant. So the assistant was the enabler.”

The court documents also revealed that he asked Sangha on whether the ketamine stays in your system or “is it immediately flushed out.”

Dr Pepper, Bots, Cans

The people who allegedly exploited Perry used coded language for ketamine and called it “Dr Pepper”, “bots”, or “cans.”

Selling overpriced drugs, taking advantage of Perry’s mental condition and falsifying medical records to make the drugs given to him look legitimate by Dr Plasencia is what took Perry’s life.

Iwamasa is said to have administered more than 20 shots of ketamine and three on the day Perry died. Whereas ketamine is only administered by a physician. Authorities also found that weeks before Perry’s death, Dr Plasencia allegedly bought 10 vials of ketamine and intended to sell to Perry.

He also injected Perry with a large dose, two days later. This caused him to “freeze up” and spiked his blood pressure.

When I Die, I Want Helping Others To Be The First Thing That’s Mentioned

Perry had always been open about his drug addictions, struggles with alcohol and his depression. He said that his openness would help others who are also struggling and wanted to be remembered by his quote which also is on the homepage of the Mattew Perry Foundation that helps others struggling with the disease of addiction: “When I die, I want helping others to be the first thing that’s mentioned.”

Five arrests have been made in the case so far.

In November, Delhi reported 67 malaria case, the highest November tally in four years. However, dengue cases have declined when compared to the same month's data from previous four years. The data is released by the Municipal Corporation of Delhi (MCD).

As per the MCD data, in November 2025, Delhi reported 67 malaria cases, whereas in 2024, it was 57; in 2023, it was 26; in 2022, the number of cases were 36; and in 2021, only 7 cases were recorded.

As for the year 2025, so far 690 cases have reported, which is slightly lower than 744 cases in 2024. However, the number is higher than 369 cases recorded in 2023. The silver lining is that no malaria-related deaths have been reported so far this year. As per the data, malaria cases have gone up in the capital since August. 203 cases were recorded in September, 252 in October, and 67 so far cases in November.

The highest numbers of cases have come from West, South and Civil Line zones of Delhi.

Among other mosquito-borne diseases, chikungunya cases have also seen a drop this month, as only 23 cases were reported so far in November. This number is lower than the 75 cases recorded in November 2024, however is higher than the 15 cases recorded in November 2023, 4 in 2022, and 8 in 2021.

What Is Malaria?

Malaria is a life-threatening disease caused by Plasmodium parasites that are transmitted through the bites of infected Anopheles mosquitoes. Common symptoms include high fever, chills, headache, nausea, vomiting, muscle pain, and fatigue. In some cases, especially when untreated, malaria can cause severe complications such as organ failure, difficulty breathing, or even death. The symptoms typically appear 10 to 15 days after being bitten and can resemble those of the flu, making early diagnosis and treatment crucial.

Are There any Ways For You To Identify Malaria?

Malaria is a life-threatening disease spread to humans by some types of mosquitoes. It is mostly found in tropical countries and is preventable and curable. The infection is caused by a parasite and does not spread from person to person. Symptoms can be mild or life-threatening.

According to the World Health Organization (WHO), mild symptoms include fever, chills and headache. Severe symptoms include fatigue, confusion, seizures, and difficulty breathing. Infants, children under 5 years, pregnant women and girls, travellers and people with HIV or AIDS are at higher risk of severe infection.

There is empirical evidence that it can also be transmitted through blood transfusion and contaminated needles. Transfusion-transmitted malaria (TTM) occurs when an uninfected person receives blood from a donor who is infected with malaria parasites. While malaria transmission through transfusion is rare, especially in non-endemic areas, it remains a significant concern in certain regions. According to a systematic review of studies conducted by National Library of Medicine, Plasmodium parasites were shown to survive in whole blood and plasma when stored at 4°C for up to 18 days, and detectable parasites can present even up to 28 days when frozen, although with diminished infectivity.

Common Symptoms Of Malaria

• extreme tiredness and fatigue
• impaired consciousness
• multiple convulsions
• difficulty breathing
• dark or bloody urine
• jaundice (yellowing of the eyes and skin)
• abnormal bleeding

Amid the continuously worsening air pollution and air quality levels in Delhi, the government has implemented a work-from-home measures under the Graded Response Action Plan (GRAP).

As per the notice by the Government of National Capital Territory of Delhi and Department of Environment & Forest, all government offices under the GNCTD and private offices operating within Delhi must now function at 50 percent staff strength, with remaining employees required to work from home.

Administrative Secretaries and Heads of Departments may only call essential staff when necessary. However, the overall attendance cannot exceed the 50 percent limit. Private offices have also been instructed to minimize vehicular movement, adopt staggered working hours, and ensure strict adherence to work-from-home protocols to reduce emissions tied to daily commuting.

Read: Living In Delhi's Toxic Air Is A 'Medical Emergency', According AIIMS Doctors

Which Offices Are Not Working From Home?

Essential services, however, are exempt from these restrictions. Hospitals, health facilities, fire services, public transport, water and sanitation departments, disaster management agencies, electricity services, and teams involved in pollution control and emergency duties will continue operating normally.

District Magistrates, Deputy Commissioners of Police and local bodies have been directed to ensure strict compliance across all private offices in Delhi. The restrictions take effect immediately and will remain in force for the full duration of GRAP Stage III, or longer if recommended by the Commission for Air Quality Management (CAQM).

Delhi AQI Today

On Tuesday morning, as of 7:30 am, Delhi woke up to 'Hazardous' air with the AQI as per the aqi.in, recorded at 426. The AQI in Delhi is showing 1.7 times higher than India's average AQI.

The particulate matters have long exceeded the safe limits stated by the World Health Organization (WHO). As of today, the PM10 level is 388 µg/m³, which is 8.6 times above the recommended WHO guidelines. Whereas PM2.5 is at 288 µg/m³, which is 19.2 times the WHO guidelines.

Also Read: Delhi Pollution Is A Major Health Hazard, Toxic Air Could Even Cause Organ Damage, According To Doctors

What Does The Doctor Say?

Dr Nikhil Modi, a senior consultant, Respiratory Critical Care and Sleep Medicine at Indraprastha Apollo Hospitals in one of his previous video had said that the pollution is an "ever-growing menace". However, he suggests, one can take simple steps to protected against that.

Like all doctors he too suggested to not go out when the pollution levels are at its peak. "You may go out only if it is very necessary, but wear a mask." As per a 2023 study by an air filter brand, Delhi's air pollution peaked at 9AM and gradually improved as the day progressed. On an average, Delhi sees roughly as half as much PM2.5 by 5PM. The doctor also draws attention on the importance of maintaining a good and healthy diet, especially lots of fruits and vegetables, which are rich in antioxidants.

Health Impact Of Air Pollution Beyond The Lungs

A report by the University of Chicago revealed that air pollution is reducing the life expectancy of Delhi residents by 7.8 years. As per a US-based NGO report by the Health Effects Institute, there has been 30 to 50% increase in lung cancer rates associated with pollutants. A recent 2024 study also revealed that air pollution is not just linked to lung cancer but it can also cause head and neck cancer.

Tata Memorial Hospital published a study in July 2024 that revealed most people who had lung cancer in India never smoked.

"Head and neck cancer is a harder link to show, and it has a much lower occurrence than lung cancers, but since they also occur as a result of smoking, similar to lung cancers, we wanted to explore any connections," said John Cramer, the neck cancer study's lead researcher. "Presumably, the link to head and neck cancer comes from what we breathe to that material affecting the lining in the head and neck. We see a lot of occurrences of where carcinogens touch or pool in the body to where cancers can occur," he explained.

The flu season has started earlier than expected in some parts of the country. The cases may erupt as soon as people start to travel, meet more people during the Thanksgiving and other upcoming holidays. However, there have been warning signs of a virus that has already set off massive outbreaks in UK and Canada, called the H3N2 subclade K.

What Is The Flu Strain Subclade K?

It is a variant of the H3N2 virus that had been circulating in other countries over the summers. Experts say the new variant is driving a surge in flu cases across Canada, Japan, and the U.K. Data from the Centers for Disease Control and Prevention shows that of nearly 150 test samples identified as part of the H3 lineage, more than half belonged to the subclade K group.

The influx of patients have been high too, as Dr Cameron Wolfe, a disease specialist at Duke University School of Medicine in Durham, North Carolina suggest, and is reported by the NBC. "At the moment, we’ve had two, three, four per day coming in," he said.

Alicia Budd, who leads the Centers for Disease Control and Prevention’s domestic influenza surveillance team, said flu activity in the United States is expected to rise steadily in the coming weeks.

How Dangerous Is The New H3N2 Flu Strain?

So far, most of the flu circulating this season is the H3N2 strain, which historically causes more hospitalizations and deaths among older adults. An early spike in cases, experts say, can heighten risks for this age group. Wolfe noted that when flu season begins unusually early, some nursing homes may still be rolling out vaccinations and some hospitals may not have fully vaccinated their staff. As a result, communities may be less protected than they typically would be if the virus peaked later in the winter.

Overall flu activity remains low, but the CDC’s latest report shows cases climbing. The agency estimates that at least 650,000 people have had the flu so far this season, with around 7,400 hospitalized and 300 deaths reported.

Budd said most of the rise in cases and emergency room visits is occurring in children. Last year, 280 children in the United States died from the flu, marking the deadliest pediatric flu season ever recorded outside the 2009 to 2010 H1N1 pandemic. No pediatric deaths have been reported yet this season, though doctors remain concerned after last winter’s rapid spread of the virus through schools, day care centers and hospitals.

“It feels like the calm before the storm,” said Dr. Buddy Creech, a pediatric infectious disease specialist at Vanderbilt University Medical Center. “We may have a difficult influenza year.”

H3N2 is known for mutating easily, and a new version of the strain, known as subclade K, appeared over the summer with several mutations. It emerged after this season’s flu shot formula had already been finalized and has already driven significant outbreaks in Canada and the United Kingdom.

Budd said the CDC is studying how well the current vaccine matches this evolving strain, but she urged people to get vaccinated regardless. Even when the circulating strain is not a perfect match, she said, the shot still helps reduce the severity of illness.

Doctors across the country are watching the latest trends closely. “Does it turn on our antenna a little bit more? Yes,” said Dr. Daniel Varga, chief physician executive at Hackensack Meridian Health in New Jersey. “It makes us even more vigilant about the monitoring we do locally.”

Dr. Melanie Kitagawa, medical director of the pediatric intensive care unit at Texas Children’s Hospital in Houston, stressed that it is not too late to get vaccinated. She said the more people who receive the flu shot before flu activity accelerates, the better protected communities will be.