“I'm not great at the advice. Can I interest you in a sarcastic comment?”

This is what ‘Friends’ actor Matthew Perry’s character Chandler Bing was known for. He was known for being funny. However, he had his own struggles in his personal life and those struggles were acute depression. He was treating it with ketamine infusion therapy which is legal in the US and the UK.

What is Ketamine infusion therapy?

Ketamine is an anaesthetic used to treat depression, anxiety and pain under supervised and controlled medical settings. However, it does have its side effects, which can lead to distortion of sight, sound and time. It can also produce calming and relaxing effects.

Ketamine increases a person’s heart rate and blood pressure. If overdosed, it can leave users confused and agitated and can cause them to hurt themselves without even realising it. It can also lead to liver damage and bladder problems.

However, when used in moderation and under the supervision of medical doctors, it can treat depression where traditional antidepressants have failed.

Prof Rupert McShane, a University of Oxford psychiatrist who runs an NHS ketamine treatment clinic told BBC that ketamine “probably turns off the area of the brain that is involved in disappointment.”

Can Ketamine Infusion Therapy Kill Someone?

In simple terms, it cannot, be if the dosage is given in a controlled setting and as prescribed. Ketamine infusion therapy uses drugs in small doses than those used for anaesthesia. It acts faster than traditional anti-depressants, but the effects also wear off way quickly. Which is why it is important to monitor patients’ mental state for relapsing back into depression and discouraging them from overdosing on it.

There are ways of giving people ketamine. One of the ways is through “infusing”, which means to use an IV drip. However, injections, nasal sprays and capsules are also methods used to give people ketamine.

Since the dosage of ketamine used in the infusion treatment is small, it being the reason of actor Perry’s death was ruled out. The medical examiner also noted that Perry’s last ketamine infusion therapy session happened more than a week before his death, which means by the time he had died, it must have worn off.

So, What Happened To Perry?

Though Perry’s last session was more than a week before, his post-mortem showed that his blood contained a high concentration of ketamine. He had died of the “acute effects” of ketamine.

If it was not his session, then how did he get ketamine?

Prosecutors alleged that his assistant gave him at least 27 shots of ketamine in four days before his death, reported BBC.

Perry has been open about his personal struggles and this is what the doctors and dealers used against him. Martin Estrada, the US attorney for California’s Central District told the BBC that people took advantage of his condition. They charged him 165 times more than what vials of ketamine cost.

Names that have come up include Dr Salvador Plasencia, drug dealers “Ketamine Queen” aka Jasveen Sangha and Eric Fleming, and Perry’s live-in assistant Kenneth Iwamasa.

Who Are These Names And What Did They Do?

Ketamine Queen or Sangha supplied drugs that led to Perry’s death. Her home was a “drug-selling emporium,” said Estrada. More than 80 vials of ketamine, and thousands of pills including methamphetamine, cocaine and Xanax were allegedly found in her house known as the “Sangha Stash House.”

Sangha is known to deal with high-end celebs and was a “major source of supply for ketamine to others as well as Perry,” said Estrada.

Dr Plasencia called Perry a “moron” while charging him $2,000 for vials that cost only $12. He sold Perry 20 vials of ketamine between September and October 2023, costing $55,000.

He was the one who taught Iwamasa, who had no medical knowledge to inject the drug. This is after he knew that “Perry’s ketamine addiction was spiralling out of control,” as per what the investigators told the BBC.

Another dealer Fleming was told by Sangha to “delete all our messages.” While Fleming pleaded guilty to conspiring to distribute drugs unlawfully, he also allegedly messaged Sangha: “Please call...Got more info and want to bounce ideas off you. I’m 90% sure everyone is protected. I never dealt with [Perry] only his assistant. So the assistant was the enabler.”

The court documents also revealed that he asked Sangha on whether the ketamine stays in your system or “is it immediately flushed out.”

Dr Pepper, Bots, Cans

The people who allegedly exploited Perry used coded language for ketamine and called it “Dr Pepper”, “bots”, or “cans.”

Selling overpriced drugs, taking advantage of Perry’s mental condition and falsifying medical records to make the drugs given to him look legitimate by Dr Plasencia is what took Perry’s life.

Iwamasa is said to have administered more than 20 shots of ketamine and three on the day Perry died. Whereas ketamine is only administered by a physician. Authorities also found that weeks before Perry’s death, Dr Plasencia allegedly bought 10 vials of ketamine and intended to sell to Perry.

He also injected Perry with a large dose, two days later. This caused him to “freeze up” and spiked his blood pressure.

When I Die, I Want Helping Others To Be The First Thing That’s Mentioned

Perry had always been open about his drug addictions, struggles with alcohol and his depression. He said that his openness would help others who are also struggling and wanted to be remembered by his quote which also is on the homepage of the Mattew Perry Foundation that helps others struggling with the disease of addiction: “When I die, I want helping others to be the first thing that’s mentioned.”

Five arrests have been made in the case so far.

From time and again experts have highlighted that flu has come early this year. In fact, they have predicted that this could be a 'nasty season', all thanks to the mutated version of H3N2 virus.

What Is The K Strain Flu?

Known as the superfly, this is H3N2 'subclade K'. It is a type of seasonal influenza A virus and people have not encountered much of it in the recent years. This is why there is less immunity against it. However, the National Health Service (NHS), UK, has already sent out a 'flu jab SOS' to vulnerable people.

NHS has confirmed that the super flu is circulating in England this year, and due to less immunity, it is making it easier to spread across people. The UK Health Security Agency (UKHSA) has urged people to get a flu jab. As per the early data, this year's vaccine has offered good protection despite the new strain.

Daniel Elkeles, chief executive of NHS Providers, said that the major concern is that H3N2 is associated with a more severe illness and superflu could be "a very nasty strain of flu". He said that UK could be experiencing a "tidal wave" of illness.

Read More: Unique Symptoms Of H3N2 Flu Strain In UK And How Long Infection Now Last

Who Needs The Flu Jab?

NHS offers free flu jabs to people who need it the most, which includes:

• anyone aged 65 or above
• those with long-term health conditions
• pregnant women
• care home residents
• carers for older or disabled people, or those who receive a carer's allowance
• people who live with someone who has a weakened immune system

NHS also includes frontline health and social care workers to get the jab.

The flu jab is also available in a nasal spray version, which could be administered to children aged 2 to 3 years as well as school-aged children, up to year 11.

Everyone else who is not in this list have to buy the jab.

Should You Buy The Flu Shot? How Long Does It Take For The Jab To Work?

Even if you are healthy, you should get the shot, say doctors. Vaccines are still working against the drifted influenza A (H3N2) subclade, also known as the super flu. The vaccines in high street chemists are sold for £20.

Anyone can be vaccinated, except for those who have a serious allergy to any of its ingredients or to the vaccine it self. The best way to know is to speak to the pharmacist and your GP.

For the vaccine to work, it usually takes up to 14 days. However, what is more important to not is that during the 14-day-long period, you are still vulnerable to catching the virus.

What Are Some Of The Misconceptions Around Flu Vaccine?

Some people think that it is the flu vaccine itself that has given them the flu, however, the truth is that while vaccine does not give you a flu, it gives your body the instruction it needs to fight off an infection, in case you catch it. While you may still catch the flu after being vaccinated, the affects will be milder and would not last as long.

The best part, the vaccine is frequently updated to match the strain or the version of flu that experts expect will be circulating.

Also Read: This ONE Key Symptom Will Help You Differentiate Flu From COVID, According To Doctor

What More Can Be Done To Protect Yourself Against The Super Flu?

Elkeles says that anyone experiencing flu or cold symptoms should wear a mask in public places. This is important for the "tidal wave" of illness in the UK. Speaking to Times Radio, he said, "When you were talking about anything like Covid, I think we need to get back into the habit that if you are coughing and sneezing, but you’re not unwell enough to not go to work, then you must wear a mask when you’re in public spaces, including on public transport, to stop the chances of you giving your virus to somebody else. And we were all very good about infection control during Covid. And we really, really need to get back to that now.”

Justin Timberlake had publicly revealed in his Instagram post about his diagnoses of Lyme disease, a tick borne illness that can cause lingering and unpredictable symptoms. The 44-year-old pop icon shared how this condition caused him "massive nerve pain", fatigue, and other symptoms as he went on his World Tour.

However, he did note that if diagnosed at an early stage, the condition is also treatable. It is spread by infected blacklegged ticks.

Justin Timberlake On Prioritizing His Health More After Being Diagnosed With Lyme Disease

In an Instagram post, he revealed that he had been battling with some health issues. In a report by PEOPLE, a source close to Jessica Biel said that the singer is prioritizing his health after the "grueling tour and Lyme disease diagnosis".

Justin Timberlake's Lyme Disease Diagnosis

Timberlake disclosed that during his Forget Tomorrow World Tour, which promoted his sixth solo album Everything I Thought It Was, he had been quietly “battling some health issues.”

“When I first got the diagnosis, I was shocked for sure,” Timberlake wrote. “But at least I could understand why I would be onstage and in a massive amount of nerve pain, or just feeling crazy fatigue or sickness.”

He admitted that the symptoms forced him to reconsider continuing the tour, saying, “I was faced with a personal decision. Stop touring? I decided the joy that performing brings me far outweighs the fleeting stress my body was feeling.”

Despite the physical toll, Timberlake pushed through his JT LIVE 25 tour leg, which included festival performances like Lollapalooza Brazil, before finally wrapping things up on July 31.

What Is Lyme Disease?

Lyme disease is caused by bacteria transmitted to humans through the bite of an infected black-legged tick. It's most common in certain parts of North America and Europe, especially during the warmer months.

The most common early sign of Lyme is a red rash that often resembles a bull’s-eye, typically appearing within 3 to 30 days after the bite.

The Center for Disease Control and Prevention (CDC), US, notes that the early symptoms can also mimic the flu, fever, chills, headache, fatigue, and muscle aches. If caught early and treated with antibiotics, most people recover completely within a few weeks.

However, for some, like Timberlake, symptoms can persist or worsen even after treatment. This condition, sometimes called Post-Treatment Lyme Disease Syndrome (PTLDS), includes ongoing fatigue, nerve pain, cognitive issues, and more.

“Lyme can be incredibly tricky because its symptoms overlap with many other conditions,” explained Dr. Christopher Bazzoli, an emergency medicine expert at the Cleveland Clinic, as reported by the New York Times. “When it’s not caught early, it can lead to a wide range of complications, from joint pain to neurological issues.”

In some untreated or severe cases, complications can include:

• Chronic fatigue
• Arthritis
• Heart palpitations
• Dizziness or shortness of breath
• Nerve pain
• Memory or concentration problems
• And in rare instances, meningitis

Doctors are still researching why some people recover quickly while others experience long-term effects. For now, treatment usually includes rest, medications for symptom relief, and in some cases, extended antibiotic therapy.

Timberlake has now joined a growing list of celebrities, including Avril Lavigne and Shania Twain, who’ve opened up about their experiences with Lyme disease in hopes of raising awareness.

Takeaway For You: If you’ve spent time in wooded or grassy areas and experience unusual fatigue, joint pain, or rashes, it’s worth getting checked for Lyme. Early diagnosis can make all the difference.

Scromting: the blend of two nightmares - screaming and vomiting. It sounds surreal, but it is as real as it could get. In an interview with the New York Post, Sydni Collins, 23, shared that she was "puking all morning." "I would let out yells or cries because nothing would come out. I was just dry heaving," she shares. This is how she ended up in the hospital with a feeding tube. What she was experiencing is called cannabis hyperemesis syndrome (CHS), a debilitating condition that triggers episodes of relentless nausea, abdominal pain, and severe vomiting in chronic weed users. She has been smoking weed daily as a teenager, since she was 16.

In the US, there are more than 2.5 million teens and 1 in 10 of them are casual cannabis users, with an additional of 600,000 teens considered to be addicted to it. Emergency rooms in the country have seen a steady rise in CHS cases over the last decade. In fact, the World Health Organization (WHO) and the Centers for Disease Control and Prevention (CDC) have also added CHS in its official diagnostic codes.

In Collins story, she became the trendsetter, because during her first hospital visit, she did not receive the diagnosis. However, her inability to eat a full meal afterward is what led to 7 ER visits in just one month. When she was finally admitted, she was only 87 pounds. She shared she would be in fetal position on the beds for hours, because that was the only way her stomach did not hurt. This is when she was finally diagnosed with 'superior mesenteric artery syndrome', which is a rare digestive disorder.

Misdiagnosis is common because there had been an absence of a diagnostic code for CHS.

What Are Experts Saying?

Dr David Streem, medical director of the Cleveland Clinic's Alcohol and Drug Recovery Center told USA TODAY that he has treated a range of patients with CHS over the years. He said that the condition is so severe that even the strongest anti-nausea medication that are given to chemotherapy patients, like Ondansetron, did not stop it.

However, there is a debate on CHS patients, and marijuana advocates like Paul Armentano, who is the deputy director of cannabis reform organization NORML, tells USA TODAY that CHS is actually "very rare" and that a lack of research on the syndrome has led to its misunderstanding. Armentano says, "The very fact that we're rebranding what was known for two decades as cannabinoid hyperemesis syndrome as scromiting. Scromiting is clearly sensational." It is made up, non-scientific, and sensational, says the cannabis advocate.

What is CHS or Cannabionoid Hyperemesis Syndrome, also known as the slang Scromting?

It is a side effect of prolonged use of marijuana. This results in nausea, vomiting, and abdominal pain.

As per Rome Foundation, a patients must meet the following criteria:

• Cyclical vomiting
• Presentation after prolonged marijuana use
• Relief of vomiting after the cessation of marijuana use

CHS was first reported in Australian medical literature in 2004. This is when a small study, published in BMJ analyzed 19 patients with cyclical vomiting after prolonged marijuana use.

While the research on what actually suddenly causes this syndrome is very limited, Armentano asks questions on if synthetic cannabis products, or a specific type of it leads to such a medical condition.

Stream said for treatment, IV drip of substance such as droperidol and haloperidol are often used in emergency rooms for CHS. Stream also said that Capsaicin, commonly referred to as hot pepper cream could also be rubbed on the abdomen for some temporary relief, along with hot showers or baths.