“I'm not great at the advice. Can I interest you in a sarcastic comment?”

This is what ‘Friends’ actor Matthew Perry’s character Chandler Bing was known for. He was known for being funny. However, he had his own struggles in his personal life and those struggles were acute depression. He was treating it with ketamine infusion therapy which is legal in the US and the UK.

What is Ketamine infusion therapy?

Ketamine is an anaesthetic used to treat depression, anxiety and pain under supervised and controlled medical settings. However, it does have its side effects, which can lead to distortion of sight, sound and time. It can also produce calming and relaxing effects.

Ketamine increases a person’s heart rate and blood pressure. If overdosed, it can leave users confused and agitated and can cause them to hurt themselves without even realising it. It can also lead to liver damage and bladder problems.

However, when used in moderation and under the supervision of medical doctors, it can treat depression where traditional antidepressants have failed.

Prof Rupert McShane, a University of Oxford psychiatrist who runs an NHS ketamine treatment clinic told BBC that ketamine “probably turns off the area of the brain that is involved in disappointment.”

Can Ketamine Infusion Therapy Kill Someone?

In simple terms, it cannot, be if the dosage is given in a controlled setting and as prescribed. Ketamine infusion therapy uses drugs in small doses than those used for anaesthesia. It acts faster than traditional anti-depressants, but the effects also wear off way quickly. Which is why it is important to monitor patients’ mental state for relapsing back into depression and discouraging them from overdosing on it.

There are ways of giving people ketamine. One of the ways is through “infusing”, which means to use an IV drip. However, injections, nasal sprays and capsules are also methods used to give people ketamine.

Since the dosage of ketamine used in the infusion treatment is small, it being the reason of actor Perry’s death was ruled out. The medical examiner also noted that Perry’s last ketamine infusion therapy session happened more than a week before his death, which means by the time he had died, it must have worn off.

So, What Happened To Perry?

Though Perry’s last session was more than a week before, his post-mortem showed that his blood contained a high concentration of ketamine. He had died of the “acute effects” of ketamine.

If it was not his session, then how did he get ketamine?

Prosecutors alleged that his assistant gave him at least 27 shots of ketamine in four days before his death, reported BBC.

Perry has been open about his personal struggles and this is what the doctors and dealers used against him. Martin Estrada, the US attorney for California’s Central District told the BBC that people took advantage of his condition. They charged him 165 times more than what vials of ketamine cost.

Names that have come up include Dr Salvador Plasencia, drug dealers “Ketamine Queen” aka Jasveen Sangha and Eric Fleming, and Perry’s live-in assistant Kenneth Iwamasa.

Who Are These Names And What Did They Do?

Ketamine Queen or Sangha supplied drugs that led to Perry’s death. Her home was a “drug-selling emporium,” said Estrada. More than 80 vials of ketamine, and thousands of pills including methamphetamine, cocaine and Xanax were allegedly found in her house known as the “Sangha Stash House.”

Sangha is known to deal with high-end celebs and was a “major source of supply for ketamine to others as well as Perry,” said Estrada.

Dr Plasencia called Perry a “moron” while charging him $2,000 for vials that cost only $12. He sold Perry 20 vials of ketamine between September and October 2023, costing $55,000.

He was the one who taught Iwamasa, who had no medical knowledge to inject the drug. This is after he knew that “Perry’s ketamine addiction was spiralling out of control,” as per what the investigators told the BBC.

Another dealer Fleming was told by Sangha to “delete all our messages.” While Fleming pleaded guilty to conspiring to distribute drugs unlawfully, he also allegedly messaged Sangha: “Please call...Got more info and want to bounce ideas off you. I’m 90% sure everyone is protected. I never dealt with [Perry] only his assistant. So the assistant was the enabler.”

The court documents also revealed that he asked Sangha on whether the ketamine stays in your system or “is it immediately flushed out.”

Dr Pepper, Bots, Cans

The people who allegedly exploited Perry used coded language for ketamine and called it “Dr Pepper”, “bots”, or “cans.”

Selling overpriced drugs, taking advantage of Perry’s mental condition and falsifying medical records to make the drugs given to him look legitimate by Dr Plasencia is what took Perry’s life.

Iwamasa is said to have administered more than 20 shots of ketamine and three on the day Perry died. Whereas ketamine is only administered by a physician. Authorities also found that weeks before Perry’s death, Dr Plasencia allegedly bought 10 vials of ketamine and intended to sell to Perry.

He also injected Perry with a large dose, two days later. This caused him to “freeze up” and spiked his blood pressure.

When I Die, I Want Helping Others To Be The First Thing That’s Mentioned

Perry had always been open about his drug addictions, struggles with alcohol and his depression. He said that his openness would help others who are also struggling and wanted to be remembered by his quote which also is on the homepage of the Mattew Perry Foundation that helps others struggling with the disease of addiction: “When I die, I want helping others to be the first thing that’s mentioned.”

Five arrests have been made in the case so far.

A recent study by the Indian Council of Medical Research (ICMR) showed that more than 40 percent of prostate cancer patients in the country are diagnosed after the cancer has spread.

The 43 percent of late diagnosis cases indicates the significant burden of late detection of prostate cancer in the country. This can not only limit treatment options but also lead to poorer survival outcomes.

The study, published in the Indian Journal of Surgical Oncology, revealed that while more than 80 per cent began treatment within two months, but referral patients experienced longer delays.

Researchers from the ICMR’s National Centre for Disease Informatics and Research, in Bengaluru, stressed the need to strengthen referral pathways to ensure timely, stage-appropriate care.

“Our study indicates that over 80 percent of patients commence treatment within two months of diagnosis, but referral systems and delays in care persist,” said corresponding author Prashant Mathur, Director, ICMR-NCDIR, in the paper.

“To address these challenges, the healthcare system must prioritize improving referral efficiency, reducing administrative bottlenecks, enhancing coordination through digital health records, and multidisciplinary tumor boards,” the authors added.

Age, The Strongest Risk Factor For Prostate Cancer

The ICMR study is based on an analysis of 9,347 cases from 96 hospitals under the National Cancer Registry Program.

The researchers found that 75.6 percent of total prostate cancer cases occurred in the age group of 60–80 years, indicating that advanced age remains the biggest risk factor for the condition.

As life expectancy increases, more men reach the higher-risk age group, but awareness and screening practices have not scaled proportionately.

Adenocarcinoma was the most common pathology, constituting 77 percent of cases.

It is the most common form of prostate cancer, accounting for over 95 per cent of all cases. It develops in the gland cells that produce prostate fluid and typically grows slowly over several years.

Further, the ICMR researchers noted that about 57 percent of cases were diagnosed with localized (29.9 percent) or locoregional (27 percent) cancer.

Thirty percent underwent surgical treatment, and 22 percent received radiation therapy. Systemic therapy was the most common single modality treatment.

“Early detection and streamlined referral pathways are essential to improve prostate cancer outcomes in India,” the researchers said.

Prostate Cancer And Its Prevalence In India

Prostate cancer forms in the cells of the prostate -- a gland found only in males and a part of the male reproductive system. It lies below the urinary bladder and in front of the rectum.

Nearly all prostate cancers develop from glandular cells (adenocarcinomas).

Globally, prostate cancer is the most frequently diagnosed cancer among men in 112 countries and the leading cause of cancer death in 48 countries. In 2020, an estimated 1.4 million new cases of prostate cancer and 0.37 million deaths were reported worldwide.

In India, it is the second most common cancer among men, accounting for more than 60 percent of the prostate cancer burden in South-Central Asia. As per the ICMR data, the country reported 34,540 incidences of prostate cancer and 16,783 deaths.

Prostate cancer symptoms include urinary difficulty, a weak stream, or blood in the urine.

As prostate cancer is a slow-developing disease, it often causes no symptoms during the early-stage, leading to delayed medical consultation.

Other reasons for late detection in India include low awareness, limited routine screening -- PSA (prostate-specific antigen) programs; social stigma and hesitation due to embarrassment or cultural taboos.

Lack of access to specialist care, diagnostic facilities, and cancer centers, especially in rural populations, coupled with cost and referral gaps, also leads to delay in diagnosis.

In a shocking video, a woman who ordered packaged eggs sold by Eggoz from Zepto claims they were filled with plastic-made strands instead of yolk, however the brand soon quoted FSSAI's rules and issued a clarification.

Earlier this week, Shalini Singh shared an Instagram video of six eggs that appear to have yellow, thread-like strands emerging from within, suggesting that instead of slimy yolk, she found a plastic substance bursting out of the eggs after boiling them.

In the clip, the visibly upset customer is heard saying: “Until now we had only heard that fake eggs or plastic eggs were being sold in the market, but today I witnessed an example in my own home. I ordered Eggoz Everyday brand eggs from Zepto and as soon as I put them on to boil, instead of yolk, plastic started coming out from inside."

Pointing at the cracked eggs, she added, “You can see in the video yourself, plastic is coming out in the form of noodles. Each egg has the Eggoz Everyday stamp on it. Look at how plastic fake eggs are reaching our homes.

“This is what we are buying today. If they had been cooked in another way, we might not even have realized we were consuming plastic. These boiled eggs burst, and that is how we found out it was plastic. If this is the condition of such big brands today, what is even left safe to eat?"

Can Egg Yolks Be Filled With Plastic?

"Consumers need to remember that the quality and appearance of the egg mostly depend on the way they are stored and for how long they are stored. Egg quality is best maintained when they are stored in cold temperatures preferably inside refrigerators and consumed within a period of 2 to 3 days.

"When kept in room temperature, several changes take place in an egg that bring about differences in the smell, texture and appearance of the egg."

The FSSAI further suggested holding up an egg against a very bright light in a dark room to detect its age. If its fresh, the egg will display a small air gap usually at the broader (blunt) end and if its starting to age, the air cell will expand in volume.

Upon hard boiling a fresh egg, you can clearly see the indentation left behind at the top of the egg once the shell is peeled off.

When fresh eggs are boiled, the yolk normally stays in the center and is not very mobile because of the chalaza (the strings of tissue) that hold it in place. These strings break down as the egg ages (during storage or transportation). When hard boiled eggs are cut length wise, one can see that the yolk has moved off the centre.

What Did The Company Say?

"Thank you for bringing this to our attention."

They also reached out with an official clarification, stating that there is no such thing as plastic eggs and that the claims stem from common misconceptions, quoting FSSAI's guidance.

In an official statement, the brand commented: "There are no plastic eggs. Eggs are a natural agricultural product, and variations in texture or appearance may occur due to storage or temperature conditions at different stages after production. Such natural changes do not indicate the presence of artificial or plastic material and do not affect food safety."

The company also highlighted its commitment to strict farm-to-shelf quality processes, including hygienic handling, batch traceability and temperature-controlled logistics.

Denmark has become the first country in the European Union (EU) to eliminate mother-to-child transmission (EMTCT) of HIV and syphilis -- two serious, and often co-occurring, sexually transmitted infections (STIs).

The World Health Organization (WHO) validated Denmark for the EMTCT of HIV and syphilis, for low transmission rates and high coverage of prenatal testing and treatment for pregnant women from 2021 to 2024.

“The elimination of mother-to-child transmission of HIV and syphilis marks a major public health achievement for Denmark,” said Dr Tedros Adhanom Ghebreyesus, WHO Director-General.

“This milestone demonstrates that with strong political commitment and consistent investment in primary care and integrated maternal and child health services, countries can protect every pregnant woman and newborn from these diseases,” he added.

With the recognition, Denmark is now among 22 other countries and territories validated by WHO for the elimination of mother-to-child transmission of HIV, syphilis, or hepatitis B virus.

How Denmark Achieved EMTCT Of HIV And Syphilis

Elimination can be defined as testing and treating at least 95 out of every 100 pregnant women. This also includes keeping new infant infections below 50 per 100,000 births, year after year.

"Denmark has met these benchmarks through strong antenatal care, reliable data systems, and respect for women's rights. We will support Denmark as it works toward full triple elimination, when it adds hepatitis B," said Dr. Hans Henri P. Kluge, WHO Regional Director for Europe.

"This validation by WHO is a proud moment for Denmark and the result of decades of work by our health-care professionals, midwives, and public health teams to ensure that every pregnant woman receives the screening and care she needs,” added Sophie Løhde, Minister for the Interior and Health, Denmark.

Denmark has low rates of HIV and syphilis among pregnant women. While 5,950 people are living in the country with HIV, less than 0.1 percent of pregnant women are affected. With regular testing and treatment, mother-to-child transmission was reduced to zero.

Further, the systematic prenatal screening and care also reduced the cases of congenital syphilis (syphilis passed from mother to baby). In 2024, the country reported 626 cases of syphilis, more in men (524) than in women (102).

The country is now on track towards validating hepatitis B virus elimination.

The prevalence of chronic hepatitis B infection in Denmark is estimated at around 0.2–0.3 percent, mainly among migrants from endemic regions.

In October 2025, the Maldives became the first country in the world to achieve ‘triple elimination’ of mother-to-child transmission of hepatitis B, HIV, and syphilis. The country had achieved WHO validation for EMTCT of HIV and syphilis in 2019.

Global Prevalence Of HIV And syphilis

Globally, more than 39 million people were living with HIV in 2022, and over 20 million cases of syphilis were reported among women of childbearing age by 2021.

Syphilis sores create entry points for HIV, while HIV can accelerate syphilis progression.

While syphilis is curable with antibiotics, HIV is manageable but not curable.

The sexually transmitted infections are also increasing in prevalence worldwide.

More than 1 million curable STIs are acquired every day worldwide in people 15–49 years old, the majority of which are asymptomatic.

STIs have a direct impact on sexual and reproductive health through stigmatization, infertility, cancers, and pregnancy complications, and can increase the risk of HIV.