“I'm not great at the advice. Can I interest you in a sarcastic comment?”

This is what ‘Friends’ actor Matthew Perry’s character Chandler Bing was known for. He was known for being funny. However, he had his own struggles in his personal life and those struggles were acute depression. He was treating it with ketamine infusion therapy which is legal in the US and the UK.

What is Ketamine infusion therapy?

Ketamine is an anaesthetic used to treat depression, anxiety and pain under supervised and controlled medical settings. However, it does have its side effects, which can lead to distortion of sight, sound and time. It can also produce calming and relaxing effects.

Ketamine increases a person’s heart rate and blood pressure. If overdosed, it can leave users confused and agitated and can cause them to hurt themselves without even realising it. It can also lead to liver damage and bladder problems.

However, when used in moderation and under the supervision of medical doctors, it can treat depression where traditional antidepressants have failed.

Prof Rupert McShane, a University of Oxford psychiatrist who runs an NHS ketamine treatment clinic told BBC that ketamine “probably turns off the area of the brain that is involved in disappointment.”

Can Ketamine Infusion Therapy Kill Someone?

In simple terms, it cannot, be if the dosage is given in a controlled setting and as prescribed. Ketamine infusion therapy uses drugs in small doses than those used for anaesthesia. It acts faster than traditional anti-depressants, but the effects also wear off way quickly. Which is why it is important to monitor patients’ mental state for relapsing back into depression and discouraging them from overdosing on it.

There are ways of giving people ketamine. One of the ways is through “infusing”, which means to use an IV drip. However, injections, nasal sprays and capsules are also methods used to give people ketamine.

Since the dosage of ketamine used in the infusion treatment is small, it being the reason of actor Perry’s death was ruled out. The medical examiner also noted that Perry’s last ketamine infusion therapy session happened more than a week before his death, which means by the time he had died, it must have worn off.

So, What Happened To Perry?

Though Perry’s last session was more than a week before, his post-mortem showed that his blood contained a high concentration of ketamine. He had died of the “acute effects” of ketamine.

If it was not his session, then how did he get ketamine?

Prosecutors alleged that his assistant gave him at least 27 shots of ketamine in four days before his death, reported BBC.

Perry has been open about his personal struggles and this is what the doctors and dealers used against him. Martin Estrada, the US attorney for California’s Central District told the BBC that people took advantage of his condition. They charged him 165 times more than what vials of ketamine cost.

Names that have come up include Dr Salvador Plasencia, drug dealers “Ketamine Queen” aka Jasveen Sangha and Eric Fleming, and Perry’s live-in assistant Kenneth Iwamasa.

Who Are These Names And What Did They Do?

Ketamine Queen or Sangha supplied drugs that led to Perry’s death. Her home was a “drug-selling emporium,” said Estrada. More than 80 vials of ketamine, and thousands of pills including methamphetamine, cocaine and Xanax were allegedly found in her house known as the “Sangha Stash House.”

Sangha is known to deal with high-end celebs and was a “major source of supply for ketamine to others as well as Perry,” said Estrada.

Dr Plasencia called Perry a “moron” while charging him $2,000 for vials that cost only $12. He sold Perry 20 vials of ketamine between September and October 2023, costing $55,000.

He was the one who taught Iwamasa, who had no medical knowledge to inject the drug. This is after he knew that “Perry’s ketamine addiction was spiralling out of control,” as per what the investigators told the BBC.

Another dealer Fleming was told by Sangha to “delete all our messages.” While Fleming pleaded guilty to conspiring to distribute drugs unlawfully, he also allegedly messaged Sangha: “Please call...Got more info and want to bounce ideas off you. I’m 90% sure everyone is protected. I never dealt with [Perry] only his assistant. So the assistant was the enabler.”

The court documents also revealed that he asked Sangha on whether the ketamine stays in your system or “is it immediately flushed out.”

Dr Pepper, Bots, Cans

The people who allegedly exploited Perry used coded language for ketamine and called it “Dr Pepper”, “bots”, or “cans.”

Selling overpriced drugs, taking advantage of Perry’s mental condition and falsifying medical records to make the drugs given to him look legitimate by Dr Plasencia is what took Perry’s life.

Iwamasa is said to have administered more than 20 shots of ketamine and three on the day Perry died. Whereas ketamine is only administered by a physician. Authorities also found that weeks before Perry’s death, Dr Plasencia allegedly bought 10 vials of ketamine and intended to sell to Perry.

He also injected Perry with a large dose, two days later. This caused him to “freeze up” and spiked his blood pressure.

When I Die, I Want Helping Others To Be The First Thing That’s Mentioned

Perry had always been open about his drug addictions, struggles with alcohol and his depression. He said that his openness would help others who are also struggling and wanted to be remembered by his quote which also is on the homepage of the Mattew Perry Foundation that helps others struggling with the disease of addiction: “When I die, I want helping others to be the first thing that’s mentioned.”

Five arrests have been made in the case so far.

Food safety has become a serious concern in the US in recent months, with a large number of products recalled over contamination, bacterial infections, and other health risks.

The latest recalls involve rice over potential foreign material contamination and mini doughnuts over undeclared milk that may trigger allergic reactions.

Mini Donuts Recalled Over Undeclared Milk

Packages of mini donuts sold nationwide are being recalled after a consumer reported an allergic reaction linked to the product, USA Today reported.

According to the US Food and Drug Administration (FDA), Better Bakehouse Snack Company is recalling certain lots of Donutful Chocolate Dipped Vanilla Cake Donuts because they may contain undeclared milk.

People with a milk allergy or severe sensitivity to milk could face a serious or life-threatening allergic reaction if they consume the affected product, the FDA said.

The food regulator noted that the consumer who suffered the allergic reaction has fully recovered. The manufacturer has identified the cause of the mislabeling and taken corrective measures.

Also read: From Dog Food To Fruit Bars: Over 10 Products Recalled In US Over Contamination

Which Doughnuts Are Being Recalled?

The recalled doughnuts are limited to a specific lot manufactured and distributed in March 2026. The product was shipped to retailers nationwide and sold through Amazon.

Consumers should check the following details to determine whether they have the recalled product:

• Product: Donutful Chocolate Dipped Vanilla Cake Donuts, 10 Mini Donuts
• Package: 7.05-ounce carton containing five 1.41-ounce (40g) pouches
• UPC: 3 50041 39210 3
• Best If Used By: September 15, 2026
• Lot Code: 26078

The FDA advises consumers to dispose of the affected product and obtain a refund from the point of purchase with a receipt, or return the product for a refund.

54,648 Pounds of Rice Recalled Over Foreign Material

An FDA update on August 25 provides more details about an April 2026 rice recall involving Lundberg Family Farms.

The company's Jasmine white rice was recalled because of potential contamination with foreign materials.

According to the FDA, 27,324 packages of 32-ounce rice were recalled, totaling 54,648 pounds. Lundberg-branded rice was also part of the recall initiated by the FDA in April this year.

The recalled rice was distributed in:

• California
• Connecticut
• Florida
• Illinois
• North Carolina
• New Hampshire
• New York
• Pennsylvania
• Tennessee
• Vermont
• Washington
• Wisconsin

Consumers can identify the affected products using these details:

• UPC: 073416040281
• Lot/Best Before: 260201MA, 01FEB2027; 260202MA, 02FEB2027

The expiration dates are February 1 and February 2, 2027. Consumers who were unaware of the earlier recall announcements may still have the affected product at home.

What Is the Risk From the Recalled Rice?

The recall follows the FDA's May 7 Class II classification.

According to the FDA, a Class II recall involves a situation in which use of or exposure to a violative product may cause temporary or medically reversible adverse health consequences, or where the likelihood of serious adverse health consequences is remote.

Belgium has been hit by a Salmonella outbreak linked to contaminated eggs, with more than 300 people falling ill, according to the country’s food safety agency. The outbreak comes after similar Salmonella outbreaks linked to contaminated eggs were reported in the US and UK.

Eggs Linked to Salmonella Outbreak

According to the Belgian Federal Agency for the Safety of the Food Chain (FASFC), the outbreak has been linked to eggs produced by Laerco, a company based in Geel in northern Belgium.

“Salmonella is relatively common in Belgium, but we never had such a broad cluster with so many people hit,” an AFSCA spokesperson said.

No deaths have been reported in connection with the Belgian outbreak. However, officials warned that the actual number of cases could be higher, as some people may have experienced mild or no symptoms and did not seek medical testing, BOL News reported.

Eggs Recalled Across Europe

Also read: UK Food Agency Warns Vulnerable Groups to Avoid Runny Eggs: Who Is At Risk And Which Foods To Avoid

Salmonella was first detected at Laerco’s Geel facility at the end of April. In May, a large-scale recall was launched, with all eggs from the site withdrawn from the market.

The affected products were distributed through several major supermarket chains, including Colruyt, Delhaize, Aldi and Carrefour.

The precautionary recall was also extended to Luxembourg. FASFC notified several other European countries that may have received the eggs, including the Netherlands, France, Italy and Portugal.

As many as 2 million potentially contaminated eggs may have been sold, according to authorities.

Poultry Farm Closed

AFSCA first discovered the contamination in May and responded by recalling the affected eggs and closing one henhouse at the farm in Flanders.

However, additional cases were reported in the following months. Officials expanded the investigation and closed the entire farm. The poultry were subsequently destroyed after a second egg recall was issued on August 10.

Secondary testing found that the bacteria had spread across multiple sheds despite initial isolation efforts, Euronews reported.

UK, US Report Salmonella Cases

Read More: From Dog Food To Fruit Bars: Over 10 Products Recalled In US Over Contamination

The Belgian outbreak comes after the UK Health Security Agency (UKHSA) linked two deaths and 474 illnesses to three separate Salmonella Enteritidis clusters across the UK.

The US is also experiencing a Salmonella outbreak linked to eggs. The US Food and Drug Administration (FDA) upgraded the recall to its highest risk level and classified nearly 1.6 million dozen eggs as “Class I”, its most serious category for products that could cause serious adverse health consequences or death.

The multistate Salmonella outbreak has been linked to Midwest Poultry Services, L.P. person.

What Is Salmonella?

Salmonella is a bacterial infection that commonly causes diarrhea and gastrointestinal illness.

Common symptoms include:

• Diarrhea
• Stomach cramps
• Vomiting
• Fever

Symptoms usually begin six hours to six days after swallowing the bacteria.

Most people recover from Salmonella infection without medical treatment. However, children, older adults and people with weakened immune systems may develop serious illness requiring medical care.

It can spread through contaminated food, including:

• Eggs
• Poultry
• Meat
• Unpasteurized dairy products
• Fresh produce

The bacteria can also spread through contact with contaminated environments or from person to person.

How To Stay Safe

Health officials have advised consumers to follow recall instructions and avoid eating affected eggs. UK officials also urged vulnerable people to avoid undercooked or runny eggs, especially when dining out.

• Refrigerate items promptly
• Cook eggs thoroughly
• Wash your hands
• Sanitize surfaces
• Check for recalls
• Wash before use.

A landmark clinical trial has found that four in five people with early-stage rectal cancer could avoid major surgery after receiving chemoradiotherapy and keep their rectum intact. This means that surgery would be reserved only for patients who really need it.

The findings from the STAR-TREC trial, funded by Cancer Research UK and Stand Up To Cancer, could completely change the way some people with early-stage rectal cancer are treated.

Researchers from University College London, the University of Birmingham and the University of Leeds found that combining chemotherapy and radiotherapy, followed by monitoring closely, allowed 80% of patients to avoid major surgery and keep their rectum.

More About The STAR-TREC Approach

Patients first receive chemoradiotherapy, which combines radiation with chemotherapy to shrink or eliminate the cancer. Doctors then closely monitor to see how the tumour responds or if the cancer grows.

If the cancer disappears or responds satisfactorily, patients can avoid major surgery. Those whose cancer does not respond adequately may still need to undergo surgery.

Also read: Two-Decade Long Study Sees 50% Higher Risk Of Distal Colon Cancer In Men With High Dietary Nitrite Intake

Four In Five Patients Avoided Surgery

The trial found that four out of five patients were able to keep their rectum, avoiding the major operation. This doesn't mean that surgery is no longer necessary for rectal cancer. The findings suggest, instead, that some carefully selected patients can be treated without removing their rectum.

Researchers say this could be particularly important because around 4,100 people in England are diagnosed with early-stage rectal cancer each year.

Also read: PM2.5 Linked To 8.82 Million Global Cancer Cases, Accounts for Largest Share Among Pollutants: Study

Why Could This Be Milestone In Rectal Cancer Treatment?

Removing part or all of the rectum can affect how bowel function even if the cancer treatment is successful.

Some patients experience increased bowel frequency, urgency, leakage or difficulty controlling bowel movements. Others may require a stoma, in which waste leaves the body through an opening in the abdomen into a colostomy bag.

Avoiding major surgery when it is medically safe could therefore not only preserve an organ but also save the person's quality of life.

Michelle Mitchell, chief executive of Cancer Research UK, described the findings as potentially “life-changing for thousands of people.”

The non-surgical approach does not mean patients can simply finish treatment and forget about the cancer.

A major concern with preserving the rectum is that cancer could return to the same area. That's why patients following this approach require constant intensive surveillance, including scans, examinations, and other necessary tests.

If cancer returns or fails to respond adequately to the treatment, surgery for rectum removal remains an important treatment option.

The study therefore represents a shift from routinely removing the rectum upon confirmation of cancer diagnosis toward a less invasive approach based on response, where doctors can determine whether surgery is actually necessary for an individual patient.