“I'm not great at the advice. Can I interest you in a sarcastic comment?”

This is what ‘Friends’ actor Matthew Perry’s character Chandler Bing was known for. He was known for being funny. However, he had his own struggles in his personal life and those struggles were acute depression. He was treating it with ketamine infusion therapy which is legal in the US and the UK.

What is Ketamine infusion therapy?

Ketamine is an anaesthetic used to treat depression, anxiety and pain under supervised and controlled medical settings. However, it does have its side effects, which can lead to distortion of sight, sound and time. It can also produce calming and relaxing effects.

Ketamine increases a person’s heart rate and blood pressure. If overdosed, it can leave users confused and agitated and can cause them to hurt themselves without even realising it. It can also lead to liver damage and bladder problems.

However, when used in moderation and under the supervision of medical doctors, it can treat depression where traditional antidepressants have failed.

Prof Rupert McShane, a University of Oxford psychiatrist who runs an NHS ketamine treatment clinic told BBC that ketamine “probably turns off the area of the brain that is involved in disappointment.”

Can Ketamine Infusion Therapy Kill Someone?

In simple terms, it cannot, be if the dosage is given in a controlled setting and as prescribed. Ketamine infusion therapy uses drugs in small doses than those used for anaesthesia. It acts faster than traditional anti-depressants, but the effects also wear off way quickly. Which is why it is important to monitor patients’ mental state for relapsing back into depression and discouraging them from overdosing on it.

There are ways of giving people ketamine. One of the ways is through “infusing”, which means to use an IV drip. However, injections, nasal sprays and capsules are also methods used to give people ketamine.

Since the dosage of ketamine used in the infusion treatment is small, it being the reason of actor Perry’s death was ruled out. The medical examiner also noted that Perry’s last ketamine infusion therapy session happened more than a week before his death, which means by the time he had died, it must have worn off.

So, What Happened To Perry?

Though Perry’s last session was more than a week before, his post-mortem showed that his blood contained a high concentration of ketamine. He had died of the “acute effects” of ketamine.

If it was not his session, then how did he get ketamine?

Prosecutors alleged that his assistant gave him at least 27 shots of ketamine in four days before his death, reported BBC.

Perry has been open about his personal struggles and this is what the doctors and dealers used against him. Martin Estrada, the US attorney for California’s Central District told the BBC that people took advantage of his condition. They charged him 165 times more than what vials of ketamine cost.

Names that have come up include Dr Salvador Plasencia, drug dealers “Ketamine Queen” aka Jasveen Sangha and Eric Fleming, and Perry’s live-in assistant Kenneth Iwamasa.

Who Are These Names And What Did They Do?

Ketamine Queen or Sangha supplied drugs that led to Perry’s death. Her home was a “drug-selling emporium,” said Estrada. More than 80 vials of ketamine, and thousands of pills including methamphetamine, cocaine and Xanax were allegedly found in her house known as the “Sangha Stash House.”

Sangha is known to deal with high-end celebs and was a “major source of supply for ketamine to others as well as Perry,” said Estrada.

Dr Plasencia called Perry a “moron” while charging him $2,000 for vials that cost only $12. He sold Perry 20 vials of ketamine between September and October 2023, costing $55,000.

He was the one who taught Iwamasa, who had no medical knowledge to inject the drug. This is after he knew that “Perry’s ketamine addiction was spiralling out of control,” as per what the investigators told the BBC.

Another dealer Fleming was told by Sangha to “delete all our messages.” While Fleming pleaded guilty to conspiring to distribute drugs unlawfully, he also allegedly messaged Sangha: “Please call...Got more info and want to bounce ideas off you. I’m 90% sure everyone is protected. I never dealt with [Perry] only his assistant. So the assistant was the enabler.”

The court documents also revealed that he asked Sangha on whether the ketamine stays in your system or “is it immediately flushed out.”

Dr Pepper, Bots, Cans

The people who allegedly exploited Perry used coded language for ketamine and called it “Dr Pepper”, “bots”, or “cans.”

Selling overpriced drugs, taking advantage of Perry’s mental condition and falsifying medical records to make the drugs given to him look legitimate by Dr Plasencia is what took Perry’s life.

Iwamasa is said to have administered more than 20 shots of ketamine and three on the day Perry died. Whereas ketamine is only administered by a physician. Authorities also found that weeks before Perry’s death, Dr Plasencia allegedly bought 10 vials of ketamine and intended to sell to Perry.

He also injected Perry with a large dose, two days later. This caused him to “freeze up” and spiked his blood pressure.

When I Die, I Want Helping Others To Be The First Thing That’s Mentioned

Perry had always been open about his drug addictions, struggles with alcohol and his depression. He said that his openness would help others who are also struggling and wanted to be remembered by his quote which also is on the homepage of the Mattew Perry Foundation that helps others struggling with the disease of addiction: “When I die, I want helping others to be the first thing that’s mentioned.”

Five arrests have been made in the case so far.

The climate crisis is also a major health crisis, but six proven measures could help prevent 1.6 million deaths every year, according to the World Health Organization (WHO).

A new WHO report, released ahead of COP31, highlights six climate and health interventions that could save lives while delivering trillions of dollars in economic and fiscal benefits.

“The climate crisis is a health crisis, but much of the harm it causes can be prevented with tools we already have,” said Dr Tedros Adhanom Ghebreyesus, WHO Director-General.

“This report shows that scaling up proven, affordable actions could save millions of lives, with the greatest gains in the countries that need them most. As governments prepare for the next round of climate negotiations, protecting health must be at the centre of climate action,” he added.

What Are The 6 Measures That Could Save 1.6 Million Lives?

Also read: Big Lancet Report: Heat-Related Deaths Rise 36% Since Paris Climate Agreement, Global Warming Blamed

The report estimates that scaling up the six actions globally could prevent 1.6 million deaths annually, equivalent to one in every 40 deaths, based on modelled projections.

The six measures include:

• Heat-health warning systems
• Climate-resilient drinking-water services
• Basic sanitation services
• Hygiene and handwashing facilities
• Cleaner household fuels and technologies for cooking and heating
• Efficient fossil fuel pricing policies

Together, these actions could also help avoid 16.7 billion tonnes of CO₂ emissions, equivalent to 31% of global annual greenhouse gas emissions, excluding land use, land-use change and forestry.

6 Climate Actions Could Deliver Trillions In Economic Benefits

Read More: Climate Change And Gut Health: How Heat, Drought And Unsafe Water Raise Risks, Global Experts Warn

Heat-health warning systems were the most cost-beneficial intervention assessed, generating an estimated US$835 in benefits for every US$1 invested. However, estimates varied across different scenarios and sensitivity analyses, ranging from US$364 to US$1,272 for every US$1 invested, the WHO said

Meanwhile, efficient fossil fuel pricing policies were estimated to deliver the largest overall economic welfare benefits, at US$3,041.10 billion. Estimates across different scenarios and sensitivity analyses ranged from US$690.59 billion to US$5,342.64 billion.

These policies were also projected to generate US$5,440.93 billion in fiscal benefits, with estimates ranging from US$3,442.96 billion to US$5,440.93 billion, the WHO said. The policies are also estimated to prevent 1.2 million deaths annually.

COP31: Health To Be A Key Focus

The 2026 United Nations Climate Change Conference, commonly known as COP31, will take place in Antalya, Türkiye, from November 9 to 20. The conference's dedicated COP31 Health Day will be held on November 9, the first day of the conference.

Governments are expected to share their climate reports and discuss ways to advance climate-resilient and environmentally sustainable health systems.

Former British Olympic sprinter Beth Dobbin, diagnosed with myalgic encephalomyelitis (ME), spends more than 22 hours a day in bed because of the debilitating condition. She is urging UK Prime Minister Andy Burnham to meet her and commit to increased government funding for ME research.

Following Dobbin's October 21 appeal, 360 sportspeople have signed a letter backing her campaign. The group includes 114 Olympians and Paralympians, who have won a combined 77 medals.

In a post on X, Dobbin expressed surprise at the response, saying: “I can’t believe 360 people signed in just 1 week, so many amazing names and messages still coming in of people wanting to add theirs (so feel free to message to add yours, we’re keeping on the pressure!!!)”

The 32-year-old retired from athletics in April 2026, describing her illness as “serious” and “life-changing”, BBC Sport reported. She had reached the 200m semi-finals at the Tokyo Olympics in 2021 and won bronze in the 4x200m relay with Scotland at the 2022 Commonwealth Games in Birmingham.

360 Sportspeople Back Beth Dobbin's Call For ME Research Funding

Also read: Swimmer Archie Goodburn’s Plea Prompts UK Brain Cancer Research Review

Among the signatories are Everton manager David Moyes, United States women's national football team manager Emma Hayes, former Chelsea and England centre-back Millie Bright, athletes Laura Muir, Eilish McColgan and Adam Gemili, Olympic sprinter Dina Asher-Smith and diver Tom Daley.

The letter calls on Burnham to “level the playing field” for ME research funding compared with other illnesses and “give hope to the many affected that something is being done about this life-destroying, much-ignored illness and its spiralling impact”.

It highlights the disparity in government research funding between ME and other conditions.

“Between 2019 to 2024, UK government research funders committed just £6.6m in funding for research into ME, compared to £79.1m for Parkinson's and £496.4m for dementia,” the letter states.

It adds that biomedical research funding for ME was “almost non-existent” before this period and that the lack of investment has contributed to the absence of approved treatments.

How Did Beth Dobbin Develop ME?

Dobbin's health began deteriorating after back-to-back COVID-19 and glandular fever infections during the winter of 2021-22, she told BBC Sport.

She experienced worsening fatigue, slower running times and soreness in the glands in her neck and armpits. Initial tests by British Athletics doctors failed to identify the cause.

Despite her symptoms, she continued training in 2022. At the European Championships, she false-started after losing all feeling in her legs while in the starting blocks.

Her condition continued to worsen. She struggled to stand and spent most of her time in bed. After consulting four or five specialists, she was diagnosed with ME.

Dobbin has since been largely confined to her home and bed. Even conversations, bright lights and loud sounds can trigger a “crash” lasting days or, in severe cases, months. According to BBC Sport, she has left her house just five times this year, mainly for medical appointments and blood tests.

Read More: Spanish Striker Jesus De Miguel Dies After On-Field Collision: Can A Blow To The Chest Trigger Cardiac Arrest?

What Is Myalgic Encephalomyelitis (ME)?

ME, also known as chronic fatigue syndrome (CFS), is a complex, chronic illness that can cause severe fatigue, pain, sleep disturbances and problems with thinking and memory.

Symptoms do not improve with rest and can fluctuate in severity. While some people can continue working or studying, others experience severe disability and may require round-the-clock care or tube feeding.

There is no known cure or specific approved treatment for ME. More than 400,000 people in the UK are thought to have the condition, although the actual number could exceed one million.

A Department of Health and Social Care spokesperson previously told BBC Sport: “Myalgic encephalomyelitis (ME) can have a devastating impact on people's lives, and we are determined to accelerate progress in understanding and treating this debilitating condition.”

The 2026 US midterm elections have delivered significant victories for Democrats, including two healthcare professionals. Physician Amy Acton defeated Republican Vivek Ramaswamy in Ohio’s gubernatorial race, while paediatrician Annie Andrews won South Carolina’s Senate race against Republican Darline Graham.

Both victories have brought healthcare professionals into the political spotlight as medical costs, insurance affordability and access to treatment remain major concerns for American voters.

Acton, a former director of the Ohio Department of Health, became widely recognised for her leadership during the COVID-19 pandemic. Andrews drew on her experience as a paediatrician to campaign on healthcare access and affordability.

"It’s the honor of my lifetime to be named your Ohio Governor-Elect," Acton said, in an Instagram post.

"South Carolina, you have shown the nation — in an era of partisan divides, of vitriol and namecalling, in a politics dominated by billionaires, special interests, and insiders in Washington — that we will not bow down. We will not back down. And we will chart our own course," added Andrews on X.

Democrats Make Major Gains In US Midterm Elections

Also read: US Midterms 2026: 125 Doctors, Nurses And Health Experts Join Election Battle

Acton's victory marks a setback for Republicans in Ohio, where the governor's office was previously held by the party. She sought to return the governorship to Democrats after two decades, despite Ohio's increasingly Republican lean in recent elections.

The closely watched contest saw Ramaswamy, a biotech entrepreneur and former 2024 Republican presidential candidate, secure the Republican nomination with endorsements from President Donald Trump and the state Republican Party.

According to the Associated Press (AP), Acton received 50.8% of the vote, against Ramaswamy's 45.9%, with 86% of ballots counted.

In South Carolina, Andrews defeated Darline Graham, the sister of the late Republican Senator Lindsey Graham. She became the first Democrat to win a US Senate seat in the state in 28 years.

What Could These Wins Mean For Healthcare Policy?

The Democratic gains could create opportunities to challenge President Donald Trump's healthcare agenda through congressional oversight and legislative action.

Healthcare affordability was a major voter concern. A Kaiser Family Foundation (KFF) poll found that six in 10 registered voters worried about medical costs. Voters trusted Democrats more than Republicans on healthcare costs (42% versus 22%) and abortion policy (42% versus 27%).

Abortion-related measures also featured on ballots in Virginia, Nevada, Idaho and Missouri, where voters considered repealing existing abortion protections.

Read More: US Midterm Elections 2026: Abortion, Medicaid, Measles And Healthcare Issues At Stake

What Did Annie Andrews And Amy Acton Promise On Healthcare?

Both candidates used their medical backgrounds to build campaigns around reducing healthcare costs, protecting patients and expanding access to treatment.

Annie Andrews' healthcare promises

The paediatrician campaigned on a 'Patients and Prices Platform'. Her key promises included:

• Lower drug prices: Expand Medicare drug price negotiations and restructure insurance rules to limit corporate profits.
• Public option: Introduce voluntary public health insurance instead of Medicare for All.
• Protect Medicaid: Reverse federal Medicaid cuts and safeguard rural hospitals.
• Public health: Expand vaccine access and strengthen maternal health services.
• Reproductive rights: Restore federal abortion protections and safeguard access to contraception and fertility treatments, including IVF.

Amy Acton's healthcare promises

The former Ohio health director focused on reducing medical debt, protecting Medicaid coverage and strengthening hospitals. Her key promises included:

• Medical debt relief: Eliminate medical debt for eligible residents earning up to 400% of the federal poverty level or whose medical debt exceeded 5% of household income.
• Lower medication costs: Launch 'Ohio Rx', a state-run online pharmaceutical platform to reduce drug prices through collective purchasing.
• Protect Medicaid: Oppose coverage cuts and establish navigator programmes to help residents retain insurance.
• Support hospitals: Provide funding to vulnerable rural and urban safety-net hospitals.
• Patient protections: Address surprise medical bills, improve insurance price transparency and prevent mid-plan medication switches.
• Reproductive rights: Defend Ohio's reproductive freedom amendment and protect access to abortion, contraception, IVF and miscarriage care.