“I'm not great at the advice. Can I interest you in a sarcastic comment?”

This is what ‘Friends’ actor Matthew Perry’s character Chandler Bing was known for. He was known for being funny. However, he had his own struggles in his personal life and those struggles were acute depression. He was treating it with ketamine infusion therapy which is legal in the US and the UK.

What is Ketamine infusion therapy?

Ketamine is an anaesthetic used to treat depression, anxiety and pain under supervised and controlled medical settings. However, it does have its side effects, which can lead to distortion of sight, sound and time. It can also produce calming and relaxing effects.

Ketamine increases a person’s heart rate and blood pressure. If overdosed, it can leave users confused and agitated and can cause them to hurt themselves without even realising it. It can also lead to liver damage and bladder problems.

However, when used in moderation and under the supervision of medical doctors, it can treat depression where traditional antidepressants have failed.

Prof Rupert McShane, a University of Oxford psychiatrist who runs an NHS ketamine treatment clinic told BBC that ketamine “probably turns off the area of the brain that is involved in disappointment.”

Can Ketamine Infusion Therapy Kill Someone?

In simple terms, it cannot, be if the dosage is given in a controlled setting and as prescribed. Ketamine infusion therapy uses drugs in small doses than those used for anaesthesia. It acts faster than traditional anti-depressants, but the effects also wear off way quickly. Which is why it is important to monitor patients’ mental state for relapsing back into depression and discouraging them from overdosing on it.

There are ways of giving people ketamine. One of the ways is through “infusing”, which means to use an IV drip. However, injections, nasal sprays and capsules are also methods used to give people ketamine.

Since the dosage of ketamine used in the infusion treatment is small, it being the reason of actor Perry’s death was ruled out. The medical examiner also noted that Perry’s last ketamine infusion therapy session happened more than a week before his death, which means by the time he had died, it must have worn off.

So, What Happened To Perry?

Though Perry’s last session was more than a week before, his post-mortem showed that his blood contained a high concentration of ketamine. He had died of the “acute effects” of ketamine.

If it was not his session, then how did he get ketamine?

Prosecutors alleged that his assistant gave him at least 27 shots of ketamine in four days before his death, reported BBC.

Perry has been open about his personal struggles and this is what the doctors and dealers used against him. Martin Estrada, the US attorney for California’s Central District told the BBC that people took advantage of his condition. They charged him 165 times more than what vials of ketamine cost.

Names that have come up include Dr Salvador Plasencia, drug dealers “Ketamine Queen” aka Jasveen Sangha and Eric Fleming, and Perry’s live-in assistant Kenneth Iwamasa.

Who Are These Names And What Did They Do?

Ketamine Queen or Sangha supplied drugs that led to Perry’s death. Her home was a “drug-selling emporium,” said Estrada. More than 80 vials of ketamine, and thousands of pills including methamphetamine, cocaine and Xanax were allegedly found in her house known as the “Sangha Stash House.”

Sangha is known to deal with high-end celebs and was a “major source of supply for ketamine to others as well as Perry,” said Estrada.

Dr Plasencia called Perry a “moron” while charging him $2,000 for vials that cost only $12. He sold Perry 20 vials of ketamine between September and October 2023, costing $55,000.

He was the one who taught Iwamasa, who had no medical knowledge to inject the drug. This is after he knew that “Perry’s ketamine addiction was spiralling out of control,” as per what the investigators told the BBC.

Another dealer Fleming was told by Sangha to “delete all our messages.” While Fleming pleaded guilty to conspiring to distribute drugs unlawfully, he also allegedly messaged Sangha: “Please call...Got more info and want to bounce ideas off you. I’m 90% sure everyone is protected. I never dealt with [Perry] only his assistant. So the assistant was the enabler.”

The court documents also revealed that he asked Sangha on whether the ketamine stays in your system or “is it immediately flushed out.”

Dr Pepper, Bots, Cans

The people who allegedly exploited Perry used coded language for ketamine and called it “Dr Pepper”, “bots”, or “cans.”

Selling overpriced drugs, taking advantage of Perry’s mental condition and falsifying medical records to make the drugs given to him look legitimate by Dr Plasencia is what took Perry’s life.

Iwamasa is said to have administered more than 20 shots of ketamine and three on the day Perry died. Whereas ketamine is only administered by a physician. Authorities also found that weeks before Perry’s death, Dr Plasencia allegedly bought 10 vials of ketamine and intended to sell to Perry.

He also injected Perry with a large dose, two days later. This caused him to “freeze up” and spiked his blood pressure.

When I Die, I Want Helping Others To Be The First Thing That’s Mentioned

Perry had always been open about his drug addictions, struggles with alcohol and his depression. He said that his openness would help others who are also struggling and wanted to be remembered by his quote which also is on the homepage of the Mattew Perry Foundation that helps others struggling with the disease of addiction: “When I die, I want helping others to be the first thing that’s mentioned.”

Five arrests have been made in the case so far.

US President Donald Trump should take a month-long break for his health, friend Bill O'Reilly has suggested.

The American conservative political commentator and television host made the remarks during a recent episode of his show.

“I noticed that he’s hunching over a little bit,” said O'Reilly, noting that he has known Trump for 35 years and expressing concern about the 80-year-old president's health, TV Insider reported.

“That’s normal. You get older, every malady in the world is going to visit you. I can’t even bore you with the stuff I gotta deal with. I was actually feeling sorry for myself the other day and I never do that.”

Offering advice, O'Reilly said Trump should “take the next month off, if you can.” He urged the president to “get into an environment” he enjoys, suggesting he spend time playing golf and “relax a little bit.”

Renewed Scrutiny Over Trump's Health

Questions about Trump's health have resurfaced during his second term following a series of public appearances.

Observers have pointed to swollen ankles, bruising on his hands, verbal slips, and occasional moments in which he appeared drowsy during meetings and international summits. Some physicians have also publicly raised concerns about the president's physical and cognitive health, although none have diagnosed him with dementia.

Trump has repeatedly rejected suggestions that he is experiencing cognitive decline or other serious health problems. His latest annual physical examination concluded that he is "in excellent health."

Bruising and Rash Draw Online Attention

Recent photographs have shown discoloration on both of Trump's hands. His right hand has repeatedly drawn attention in recent months for bruising that often appeared to be covered with concealer, while newer images also showed discoloration on his left hand.

“Bruising and discoloration was visible today on Trump's left hand, which is not the one that is usually mangled,” independent journalist Aaron Rupar wrote on social media platform X.

Earlier this month, Trump was also photographed with a visible neck rash and a bruised right hand that appeared to be covered with makeup during the 2026 NATO Summit in Türkiye. The back of his right hand appeared noticeably darker than the surrounding skin, suggesting cosmetic coverage, The Independent reported.

Trump has also been unsteady on his feet on some occasions, particularly while using stairs.

White House Dismisses Concerns

The White House has repeatedly rejected concerns about Trump's health, attributing the bruising to the physical demands of his schedule.

"President Trump is the sharpest, most accessible, and energetic president in American history," White House spokesperson Davis Ingle said in a statement to The Independent.

In February, White House Press Secretary Karoline Leavitt similarly said the bruising was caused by frequent handshaking.

Following Trump's most recent medical examination in May, White House physician Dr. Sean Barbabella said the bruising was consistent with "minor soft tissue irritation related to frequent handshaking" while the president was taking aspirin as a preventive measure against cardiovascular disease.

After the check-up at Walter Reed, Trump wrote on Truth Social that "everything" had "checked out PERFECTLY."

The White House has also addressed concerns over swelling around Trump's ankles, saying it is caused by blood pooling in the lower legs—a common condition among older adults.

Quitting smoking remains one of the best decisions for your health. But new research suggests that even years after your last cigarette, your lungs may continue to carry the harmful effects that increase the risk of chronic lung disease.

A new study by McGill University, published in the journal Translational Research, finds why former smokers remain at high risk to lung diseases even after quitting.

By analysing lung cells closely, scientists found that even though some damage due to smoking heals over time, other damages persist, leaving ex-smokers at a higher risk of conditions like chronic obstructive pulmonary disease (COPD) and lung cancer.

What Did The Study Find?

The study was conducted on more than 100,000 individual lung cells collected from 21 people, including nine people who had never smoked, five active smokers, and seven former smokers.

Using single-cell RNA sequencing, researchers examined molecular activity across more than 40 different lung cell types, creating one of the most comprehensive maps of how smoking and smoking cessation affect the lungs at the cellular level.

Their findings revealed that long-term lung recovery is not uniform. While some lung cells gradually regained healthier patterns after smoking cessation, others continued to show long-term molecular changes affecting tissues, immune responses, blood vessel function, and the overall lung health.

Perhaps the most surprising finding was that some cells in ex-smokers showed unique molecular markers that were not seen in active smoker and participants who never smoked, suggesting quitting smoking creates its own biological impact.

Also read: Even Light Exercise Could Help People With COPD Live Longer, Study Finds

Why Does Lung Disease Risk Persist After Quitting?

Scientists have long known that the risk of lung cancer and COPD declines after quitting smoking, but it never completely returns to the same level as seen in people who have never touched a cigarette.

Smoking damages DNA, alters gene activity, triggers chronic inflammation and injures delicate lung tissues. While the body repairs some of this damage after the smoker quits, certain cellular changes become persistent.

These lingering molecular alterations could continue influencing how lung tissue responds to injury, infections and aging.

Senior author Professor Carolyn Baglole, from McGill University's Department of Pharmacology and Therapeutics, said, "Current smokers have the highest risk of deadly diseases like lung cancer, but former smokers still face a higher risk than people who never smoked. Despite more than a century of research on smoking, we don't fully understand why."

She added, "Our findings show that while some damage appears reversible, other changes persist long after people stop smoking."

First author Nicole Heimbach, a doctoral student at McGill University, said, "These findings are an important step toward understanding what damage caused by smoking can heal and what may be permanent. By knowing what damage remains after quitting, we can better understand how smoking-related diseases develop and how to treat them."

Also read: Could Wildfire Smoke Trigger Your Migraine? Latest Study Finds A Strong Link

Thinking Of Switching To Vaping Instead Of Quitting Cigarettes?

Instead of quitting smoking, if you are thinking of switching to vaping, think again. According to a new study, vape users presented reduced fitness and impaired blood vessel function similar to traditional cigarette smokers.

The research, published in the peer-reviewed journal ERJ Open Research, compared healthy adults aged 18 to 30 and found that both regular vapers and smokers had around 15% lower exercise capacity than people who had never smoked or vaped.

This suggests that electronic cigarettes like vapes are not lesser of two evils.

The researchers, however, caution that the study does not suggest that vaping is equally harmful as smoking in every respect.

Traditional cigarettes still strongly remain linked to major disorders like cancer, chronic obstructive pulmonary disease (COPD), and many other life-threatening illnesses.

But the new study indicates that when it comes to cardiovascular fitness, breathing efficiency, lung function and blood vessel health in young adults, vaping may offer far less protection.

People who use cannabis frequently believing it relieves stress are about to be proven wrong. A new study debunked the myth that marijuana helps alleviate stress levels.

In fact, researchers recently found that frequent cannabis users may face the risk of higher levels of cortisol, body's stress hormone.

While the study does not prove that marijuana causes chronic stress, they raise important questions about how regular cannabis use affects long-term mental and physical health.

What Did The Study Find?

The study, conducted by researchers at Oregon State University and published in the journal Cannabis, examined 82 young adults, including 39 frequent cannabis users and 43 non-users.

Participants provided saliva samples immediately after waking and again 30 minutes later, allowing researchers to measure the cortisol awakening response (CAR), a natural surge in cortisol that prepares the body for the day.

The researchers found that frequent cannabis users had higher cortisol levels immediately upon waking compared to non-users. However, both groups showed a similar cortisol increase during the first 30 minutes after waking.

This suggests that cannabis users started the day with an already elevated stress hormone level rather than having an exaggerated morning cortisol surge.

Also read: 10 Odd Signs Of Stress That You Thought You Knew But Don't

Cortisol Isn't Just The 'Stress Hormone'

Cortisol, often called the stress hormone, plays several essential roles in the body. It helps regulate:

• Blood pressure
• Blood sugar
• Metabolism
• Immune function
• Body's response to physical and emotional stress

A temporary rise in cortisol is normal and even beneficial. But, chronically elevated cortisol has been linked to anxiety, depression, cardiovascular disease, metabolic disorders, and impaired immune function.

Why People Use Cannabis For Stress?

Many users experience short-term relaxation after consuming marijuana, particularly due to THC's effects on the brain's cannabinoid receptors.

However, researchers say repeated exposure may gradually alter the hypothalamic-pituitary-adrenal (HPA) axis, the body's central stress-response network.

Over time, this could interfere with normal stress regulation, potentially creating a cycle where people increasingly rely on cannabis to cope with stress while their biological stress system becomes dysregulated.

However, researchers clarify that the study does not establish that frequent marijuana use directly causes increase in cortisol.

Also read: Could Wildfire Smoke Trigger Your Migraine? Latest Study Finds A Strong Link

The findings add to a growing body of evidence suggesting that heavy cannabis consumption may have complex effects on mental health. Recent research has linked it with:

• Increased risk of anxiety and depressive symptoms
• Higher likelihood of cannabis use disorder
• Greater risk of psychosis in susceptible individuals
• Cognitive problems, including impaired memory with long-term heavy use
• Experts note that these risks appear to increase with more frequent use, higher THC potency, and younger age at first use.

Many people use marijuana to unwind after a stressful day, but this study suggests that frequent cannabis use may be associated with higher baseline stress hormone levels upon waking. This could affect one's day-to-day quality of life.

As cannabis use continues to rise worldwide, researchers say understanding its long-term effects on mental health and the body's stress response will be increasingly important, especially to bust common myths associated to its use.